Details of the Drug

General Information of Drug (ID: DMOBLGK)

• Drug Name: Tromethamine
• Synonyms: Trometamol; 77-86-1; TROMETHAMINE; Tris; Tris(Hydroxymethyl)aminomethane; Tham; Trisamine; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; Trizma; Tris buffer; Tris base; Tromethane; Trisaminol; Talatrol; Trispuffer; Trisamin; Pehanorm; Tutofusin tris; Tris-steril; Apiroserum Tham; Addex-tham; Tris-base; Tris, free base; Trimethylolaminomethane; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-; Tris Amino; Aminotrimethylolmethane; Aminotris(hydroxymethyl)methane; THAM-E; Tris (buffering agent); Tris(Hydroxymethyl)Aminomethane

Indication

Disease Entry	ICD 11	Status	REF
Acidosis	5C73	Approved	[1]

• ATC Code:
  B05BB03: Tromethamine
  B05BB: Solutions affecting the electrolyte balance
  B05B: I.V. SOLUTIONS
  B05: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
  B: BLOOD AND BLOOD FORMING ORGANS
  : Tromethamine
  B05XC: Vitamins
  B05X: I.V. SOLUTION ADDITIVES
  B05: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
  B: BLOOD AND BLOOD FORMING ORGANS
  B05XX02: Tromethamine
  B05XX: Other i.v. solution additives
  B05X: I.V. SOLUTION ADDITIVES
  B05: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
  B: BLOOD AND BLOOD FORMING ORGANS
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 121.14
  Logarithm of the Partition Coefficient (xlogp); -2.9
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 4
  Hydrogen Bond Acceptor Count (hbondacc); 4
• Chemical Identifiers:
  Formula: C4H11NO3
  IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol
  Canonical SMILES: C(C(CO)(CO)N)O
  InChI: InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
  InChIKey: LENZDBCJOHFCAS-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 6503
  ChEBI ID: CHEMBL9754
  CAS Number: 77-86-1
  UNII: 023C2WHX2V
  DrugBank ID: DB03754
  TTD ID: D03ZFN
  ACDINA ID: D01507
• Drug ADMET Endpoint Profile (DAE)NEW: Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
S-adenosylmethionine decarboxylase proenzyme (AMD1)	TTBFROQ	DCAM_HUMAN	Inhibitor	[2]

Molecular Expression Atlas of This Drug

• The Studied Disease: Acidosis
• ICD Disease Classification: 5C73

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
S-adenosylmethionine decarboxylase proenzyme (AMD1)	DTT	AMD1	4.41E-05	0.37	0.61

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Tromethamine (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Choline salicylate	DM8P137	Moderate	as urine pH determines the ionization state of weakly acidic or weakly alkaline drugs. Tromethamine caused by Choline salicylate mediated altered urine pH.	Postoperative inflammation [1A00-CA43]	[3]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Hydrochloric acid	E00015	313	Acidulant
Potassium phosphate monobasic	E00429	516951	Buffering agent
Edetate disodium	E00186	8759	Complexing agent
Ethanol	E00023	702	Antimicrobial preservative; Penetration agent; Solvent
Hydroxypropyl cellulose	E00632	Not Available	Binding agent; Coating agent; Emulsifying agent; Film/Membrane-forming agent; Modified-release agent; Suspending agent; Viscosity-controlling agent
Hypromellose	E00634	Not Available	Coating agent
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Polyethylene glycol 4000	E00654	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Sodium chloride	E00077	5234	Diluent; Tonicity agent
Sodium hydroxide	E00234	14798	Alkalizing agent
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Water	E00035	962	Solvent
Cellulose microcrystalline	E00698	Not Available	Adsorbent; Suspending agent; Diluent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Tromethamine 10mg tablet	10mg	Tablet	Oral
Tromethamine 30mg/ml powder	30mg/ml	Powder	Intravenous
Tromethamine 60mg/2ml powder	60mg/2ml	Powder	Intravenous
Tromethamine 15.75mg spray	15.75mg	Spray	Nasal

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7328).
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] Berg KJ "Acute effects of acetylsalicylic acid in patients with chronic renal insufficiency." Eur J Clin Pharmacol 11 (1977): 111-6. [PMID: 837963]