Details of the Drug

General Information of Drug (ID: DMOEARH)

Drug Name
AZD2014
Synonyms
AZD2014; 1009298-59-2; Vistusertib; AZD-2014; AZD 2014; UNII-0BSC3P4H5X; 0BSC3P4H5X; cc-551; 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide; CHEMBL2336325; 3-[2,4-Bis((3S)-3-methyLmorpholin-4-yl)pyrido-[5,6-e]pyrimidin-7-yl]-N-methylbenzamide; C25H30N6O3; 3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide; 3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide; Vistusertib [INN]; Vistusertib [USAN]; Vistusertib (JAN/INN)
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 462.5
Logarithm of the Partition Coefficient (xlogp) 2.8
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C25H30N6O3
IUPAC Name
3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide
Canonical SMILES
C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOC[C@@H]5C
InChI
InChI=1S/C25H30N6O3/c1-16-14-33-11-9-30(16)23-20-7-8-21(18-5-4-6-19(13-18)24(32)26-3)27-22(20)28-25(29-23)31-10-12-34-15-17(31)2/h4-8,13,16-17H,9-12,14-15H2,1-3H3,(H,26,32)/t16-,17-/m0/s1
InChIKey
JUSFANSTBFGBAF-IRXDYDNUSA-N
Cross-matching ID
PubChem CID
25262792
CAS Number
1009298-59-2
UNII
0BSC3P4H5X
DrugBank ID
DB11925
TTD ID
D0Z2UQ
INTEDE ID
DR1837
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mammalian target of rapamycin complex 1 (mTORC1) TTX4GLS MTOR_HUMAN-RPTOR_HUMAN-LST8_HUMAN-AKTS1_HUMAN-DPTOR_HUMAN Inhibitor [2]
Serine/threonine-protein kinase mTOR (mTOR) TTCJG29 MTOR_HUMAN Inhibitor [3]
Target of rapamycin complex 2 MAPKAP1 (MTORC2) TTWDKCL SIN1_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [4]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Gene/Protein Processing [5]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [5]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Gene/Protein Processing [5]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Post-Translational Modifications [5]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Gene/Protein Processing [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serine/threonine-protein kinase mTOR (mTOR) DTT MTOR 2.16E-05 -0.44 -2.3
Cytochrome P450 2C8 (CYP2C8) DME CYP2C8 1.73E-04 1.53E-01 7.44E-01
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 3.51E-02 1.53E+00 1.16E+00
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 5.84E-01 -1.61E-01 -3.61E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 0.6231 3.7664 0.2442 35.8253
CHSA0108 GDSC1 -1.917 6.5838 -3.5277 57.3131
MG-63 GDSC1; GDSC2 -1.6277 5.6224 -2.8452 49.7893
ES1 GDSC1 -1.4107 2.8926 -1.7323 57.0212
CHSA0011 GDSC1 -0.7505 7.1187 -2.5255 50.4589
ES5 GDSC1; GDSC2 -0.6498 5.1553 -1.622 42.5704
EW-7 GDSC1; GDSC2 -0.4207 3.347 -0.7693 38.9447
SK-PN-DW GDSC1; GDSC2 -0.3389 4.1215 -0.9171 38.9508
EW-3 GDSC1; GDSC2 -0.1607 10.3465 -3.3921 42.8438
ES8 GDSC1; GDSC2 -0.1138 5.0339 -1.0028 37.9536
ES7 GDSC1; GDSC2 0.1366 6.2716 -1.2432 37.3667
SK-ES-1 GDSC1; GDSC2 0.5341 4.6608 -0.168 31.4182
EW-18 GDSC1; GDSC2 0.5409 5.224 -0.3828 32.318
SJSA-1 GDSC1 0.5426 7.2598 -1.2641 41.3113
EW-22 GDSC1; GDSC2 0.704 5.8024 -0.454 31.8376
CAL-72 GDSC1; GDSC2 0.9317 6.6909 -0.6141 31.447
A-673 GDSC1; GDSC2 0.9504 5.2951 0.0177 28.6034
NOS-1 [Human HNSCC] GDSC1; GDSC2 1.0428 9.5349 -1.8413 35.0059
TC-71 GDSC1; GDSC2 1.0581 5.8717 -0.1193 28.7658
G-292 clone A141B1 GDSC1; GDSC2 1.4411 7.9796 -0.7138 29.6917
MHH-ES-1 GDSC1; GDSC2 1.5423 6.9435 -0.124 26.7427
HuO9 GDSC1; GDSC2 1.6927 7.5452 -0.2643 26.7889
H-EMC-SS GDSC1; GDSC2 1.8696 7.8554 -0.2455 26.0211
EW-13 GDSC1; GDSC2 1.8743 7.1312 0.1083 24.3142
EW-16 GDSC2 1.9422 7.4929 -0.0013 24.5947
SaOS-2 GDSC1; GDSC2 2.0733 9.7454 -0.9818 28.3361
EW-24 GDSC1; GDSC2 2.0896 7.2916 0.2353 22.8606
HOS GDSC1; GDSC2 2.2842 5.8909 1.0956 17.3629
EW-1 GDSC1; GDSC2 2.3966 6.575 0.872 18.2659
NY GDSC1; GDSC2 2.5034 12.3787 -1.9054 30.0169
ES4 GDSC1; GDSC2 2.6247 4.8719 1.91 11.1958
CADO-ES1 GDSC1; GDSC2 2.7746 11.085 -1.0247 26.131
U2OS GDSC1; GDSC2 2.8516 11.1431 -0.9872 25.7406
ES6 GDSC1; GDSC2 2.8686 9.0533 0.0702 20.9985
CHSA8926 GDSC1; GDSC2 2.9225 11.2124 -0.9609 25.4138
HuO-3N1 GDSC1; GDSC2 3.2517 10.6829 -0.4172 22.106
CAL-78 GDSC1; GDSC2 3.6759 10.3166 0.115 18.3166
EW-11 GDSC1; GDSC2 4.2049 12.0458 -0.3278 18.9918
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 160 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -1.0057 7.1008 -2.783 52.0243
MOLM-16 GDSC1 -3.8131 0.3818 -3.902 78.0066
RPMI-8402 GDSC1 -3.6408 0.5339 -3.7358 76.7816
CRO-AP2 GDSC1 -3.0433 1.6709 -3.2536 70.6384
JeKo-1 GDSC1 -2.6721 2.6142 -3.0407 66.4683
NKM-1 GDSC1 -2.6213 3.4606 -3.2025 64.6502
NCI-H929 GDSC1; GDSC2 -2.6201 0.8091 -2.6879 58.8261
SU-DHL-16 GDSC1 -2.3805 0.607 -2.4209 68.6562
DEL GDSC1; GDSC2 -2.3518 3.9546 -3.0537 54.8461
MOLP-8 GDSC1; GDSC2 -2.1658 2.8727 -2.5506 54.0276
Mono-Mac-6 GDSC1 -2.1595 4.9559 -3.1743 60.0519
KMS-11 GDSC1 -2.0654 2.8532 -2.4364 62.1734
A4/Fukuda GDSC1; GDSC2 -2.0518 4.4617 -2.8892 52.6911
OCI-Ly7 GDSC1 -1.98 0.8556 -2.0217 64.6566
RCH-ACV GDSC1 -1.955 1.6201 -2.0774 63.2444
Ku812 GDSC1; GDSC2 -1.6897 6.4719 -3.2422 50.1708
MC116 GDSC1 -1.59 1.9848 -1.7417 59.5296
MOLM-13 GDSC1; GDSC2 -1.5777 1.3477 -1.6432 49.207
MV4-11 GDSC1; GDSC2 -1.5308 1.4449 -1.6041 48.7619
Sc-1 GDSC1 -1.3282 5.476 -2.4692 54.6112
Jiyoye GDSC1; GDSC2 -1.2453 5.2346 -2.2899 47.1341
Kasumi-1 GDSC1; GDSC2 -1.2097 5.0721 -2.1918 46.827
PL-21 GDSC1 -1.197 6.5542 -2.7556 53.3237
Raji GDSC1; GDSC2 -1.102 4.4875 -1.8681 45.788
JURL-MK1 GDSC1; GDSC2 -1.0284 5.7332 -2.2483 45.7619
KCL-22 GDSC1; GDSC2 -1.0052 4.1545 -1.6515 44.8437
QIMR-WIL GDSC1 -0.9884 7.8939 -3.1063 51.776
SR GDSC1; GDSC2 -0.9499 2.5986 -1.1643 43.5095
697 GDSC1; GDSC2 -0.9405 2.1881 -1.0765 43.2145
RPMI-8226 GDSC1; GDSC2 -0.9125 4.7993 -1.7729 44.4357
MM1.S GDSC2 -0.8761 2.112 -0.9949 42.5419
WSU-NHL GDSC1; GDSC2 -0.8134 3.5709 -1.2614 42.8219
Daudi GDSC1; GDSC2 -0.7622 4.2751 -1.4277 42.8608
H9 GDSC1; GDSC2 -0.7448 8.4445 -3.1004 45.1066
NB4 GDSC1 -0.7123 3.7977 -1.2193 50.3208
U-698-M GDSC1; GDSC2 -0.6549 4.0764 -1.2453 41.773
SU-DHL-5 GDSC1; GDSC2 -0.5614 1.6539 -0.6033 39.1578
A3/Kawakami GDSC1; GDSC2 -0.5305 4.0811 -1.1117 40.6626
BC-1 GDSC1; GDSC2 -0.5286 2.608 -0.709 39.3779
HAL-01 GDSC1; GDSC2 -0.5006 5.8476 -1.7343 41.9377
ARH-77 GDSC1; GDSC2 -0.4849 4.8372 -1.3264 40.948
L-363 GDSC1; GDSC2 -0.385 4.5977 -1.1318 39.8563
OCI-Ly19 GDSC1 -0.3801 14.9024 -5.7832 48.9577
BV-173 GDSC1; GDSC2 -0.3468 6.2545 -1.7397 41.1107
Ramos.2G6.4C10 GDSC1; GDSC2 -0.334 3.1508 -0.6225 37.9061
OPM-2 GDSC1; GDSC2 -0.2931 1.4285 -0.3085 36.3521
P32/ISH GDSC1; GDSC2 -0.273 4.4457 -0.9569 38.6969
MHH-PREB-1 GDSC1; GDSC2 -0.2359 2.8172 -0.4356 36.6029
GA-10 GDSC1; GDSC2 -0.2303 5.1689 -1.1791 39.114
CMK GDSC1 -0.2292 3.6206 -0.6391 45.4364
HT GDSC1 -0.1853 7.2295 -1.9907 46.7285
SUP-B8 GDSC1 -0.1832 2.167 -0.2611 44.1111
CTB-1 GDSC1 -0.1503 12.9395 -4.6173 47.8659
Karpas-620 GDSC1; GDSC2 -0.1184 4.3606 -0.76 37.1786
MEG-01 GDSC1; GDSC2 -0.0989 6.3098 -1.5041 39.2695
Karpas-299 GDSC1 -0.0977 6.2613 -1.4825 45.6665
SU-DHL-4 GDSC1 -0.0941 2.2 -0.1705 43.0261
AMO1 GDSC1; GDSC2 -0.0926 3.0076 -0.3236 35.336
SUP-M2 GDSC1; GDSC2 -0.0408 3.6268 -0.4355 35.5249
DoHH2 GDSC2 -0.0274 1.8461 -0.0603 33.7742
RPMI-8866 GDSC1; GDSC2 0.0024 3.7592 -0.429 35.2642
P31/FUJ GDSC1 0.0717 5.9154 -1.1604 44.0599
JVM-2 GDSC1; GDSC2 0.1354 6.9488 -1.5386 38.1829
SU-DHL-6 GDSC1; GDSC2 0.1855 1.7244 0.1698 31.5534
EoL-1 GDSC1; GDSC2 0.2219 6.5832 -1.2896 37.0784
TUR GDSC1; GDSC2 0.224 4.8069 -0.5552 34.5971
L-1236 GDSC1; GDSC2 0.2469 4.6373 -0.4667 34.1286
JSC-1 GDSC1; GDSC2 0.3101 7.3578 -1.5432 37.3603
P30/OHK GDSC1; GDSC2 0.3176 5.8704 -0.8846 35.3268
ATN-1 GDSC1; GDSC2 0.3224 4.1748 -0.2186 32.6953
DG-75 GDSC1; GDSC2 0.3751 10.0738 -2.7413 39.6918
SCC-3 GDSC2 0.4223 5.5267 -0.6316 33.8927
OCI-AML-2 GDSC1; GDSC2 0.4796 4.8412 -0.2955 32.2462
L-540 GDSC1; GDSC2 0.4854 5.7387 -0.6541 33.6705
DB GDSC1; GDSC2 0.5641 10.4551 -2.7411 38.9372
BL-41 GDSC1; GDSC2 0.67 2.9523 0.5197 27.3851
EJM GDSC1; GDSC2 0.6736 5.5345 -0.3719 31.6382
OCI-M1 GDSC1; GDSC2 0.7023 5.5121 -0.3325 31.3348
RL GDSC1 0.7171 22.9831 -8.7557 46.6073
IM-9 GDSC1; GDSC2 0.7375 7.581 -1.2159 34.4544
GDM-1 GDSC1; GDSC2 0.772 8.0518 -1.4002 34.8738
NALM-6 GDSC1; GDSC2 0.7761 7.2602 -1.0299 33.6697
ML-2 GDSC1; GDSC2 0.7888 7.6797 -1.2105 34.211
VAL GDSC1; GDSC2 0.8069 8.5807 -1.6142 35.3461
JVM-3 GDSC1; GDSC2 0.928 8.493 -1.4548 34.3732
Karpas-422 GDSC1; GDSC2 0.9561 11.3854 -2.8185 37.599
EM-2 GDSC1; GDSC2 1.0986 9.6843 -1.86 34.8359
Namalwa GDSC1; GDSC2 1.0993 5.365 0.143 27.3299
CA46 GDSC1; GDSC2 1.1375 6.8464 -0.4788 29.9984
RPMI-6666 GDSC1; GDSC2 1.3274 7.9802 -0.8239 30.5782
Karpas-45 GDSC1; GDSC2 1.3567 6.8852 -0.2792 28.2114
MN-60 GDSC1; GDSC2 1.3874 7.7976 -0.679 29.7707
KMOE-2 GDSC1; GDSC2 1.3913 6.6258 -0.1244 27.3627
YT GDSC1 1.4199 8.8561 -1.1552 36.3991
OCI-AML-3 GDSC1; GDSC2 1.473 8.5048 -0.9353 30.4124
HH [Human lymphoma] GDSC1; GDSC2 1.4872 9.1036 -1.2111 31.3389
Karpas-1106P GDSC1; GDSC2 1.5402 5.2422 0.6515 22.7893
RS4;11 GDSC1; GDSC2 1.5437 10.395 -1.7874 32.942
Jurkat GDSC1; GDSC2 1.5818 3.9053 1.2367 19.33
CESS GDSC1; GDSC2 1.5976 8.0637 -0.6042 28.6285
SKM-1 GDSC1; GDSC2 1.6518 11.3815 -2.1723 33.6165
ST486 GDSC1; GDSC2 1.6674 6.7822 0.0743 25.29
CTV-1 GDSC1; GDSC2 1.7288 7.2365 -0.0819 25.8028
CML-T1 GDSC1; GDSC2 1.7372 6.1237 0.4514 23.077
LAMA-84 GDSC1; GDSC2 1.7976 9.0123 -0.8757 28.9394
CCRF-CEM GDSC1; GDSC2 1.8155 6.5704 0.3187 23.4691
VL51 GDSC1; GDSC2 1.8167 9.3452 -1.0207 29.4145
MLMA GDSC1; GDSC2 1.8742 9.479 -1.033 29.2475
PF-382 GDSC1; GDSC2 1.8795 7.3707 -0.0019 24.8359
Loucy GDSC1; GDSC2 1.8951 5.5214 0.8865 20.0473
EHEB GDSC1 1.8977 15.0864 -3.7856 39.7921
KE-37 GDSC1; GDSC2 1.9037 6.2841 0.54 21.9495
P12-Ichikawa GDSC1; GDSC2 1.9097 7.7716 -0.167 25.5069
MOLT-16 GDSC1; GDSC2 2.0316 5.7061 0.9367 19.2324
NOMO-1 GDSC1; GDSC2 2.0384 8.3004 -0.3039 25.6545
KMS-12-BM GDSC2 2.0468 6.8579 0.4044 22.1356
BE-13 GDSC1; GDSC2 2.1224 6.9688 0.4227 21.7572
BALL-1 GDSC1; GDSC2 2.1322 7.1063 0.3654 22.0257
TK [Human B-cell lymphoma] GDSC1; GDSC2 2.2651 8.2 -0.0455 23.6226
SUP-T1 GDSC1; GDSC2 2.2781 6.1383 0.9712 18.1147
EB2 GDSC1; GDSC2 2.3232 7.4865 0.3582 21.3717
GR-ST GDSC1; GDSC2 2.3306 6.9262 0.6391 19.8206
KOPN-8 GDSC1; GDSC2 2.3748 6.6198 0.8297 18.5859
L-428 GDSC1; GDSC2 2.3924 7.8534 0.2415 21.7363
ALL-PO GDSC1; GDSC2 2.4813 8.5476 -0.0208 22.7432
NU-DUL-1 GDSC1 2.5234 6.8529 0.8536 21.9363
THP-1 GDSC1 2.5396 12.1163 -1.7431 33.3538
SUP-HD1 GDSC1; GDSC2 2.5457 5.9082 1.3361 14.99
SU-DHL-10 GDSC1; GDSC2 2.5612 7.7912 0.4255 20.1826
SUP-B15 GDSC2 2.5898 5.3254 1.6597 12.8586
Reh GDSC1; GDSC2 2.6363 6.8474 0.9596 16.926
KG-1 GDSC1; GDSC2 2.6857 7.178 0.841 17.4481
DND-41 GDSC1; GDSC2 2.7816 5.3997 1.8043 11.2997
HEL GDSC1; GDSC2 2.8889 6.7513 1.2342 14.4558
JJN-3 GDSC1; GDSC2 2.9071 5.0872 2.0736 9.1981
ALL-SIL GDSC1; GDSC2 2.994 9.3785 0.0162 20.8641
LP-1 GDSC1; GDSC2 3.0553 7.806 0.854 16.175
HC-1 GDSC1; GDSC2 3.1056 6.0096 1.7938 10.3145
LC4-1 GDSC1; GDSC2 3.1303 10.5051 -0.4305 22.5382
U266B1 GDSC1; GDSC2 3.1653 10.1953 -0.2461 21.5872
K-562 GDSC1; GDSC2 3.2701 10.6939 -0.4074 22.0061
HDLM-2 GDSC1; GDSC2 3.2821 11.6175 -0.8591 23.9032
WIL2 NS GDSC1; GDSC2 3.2965 7.3992 1.2621 13.0246
OCI-AML-5 GDSC1; GDSC2 3.3578 6.5239 1.7507 9.8302
MOLT-13 GDSC1; GDSC2 3.4111 6.2622 1.9255 8.5801
HL-60 GDSC1; GDSC2 3.4439 9.0962 0.5358 16.782
Granta-519 GDSC1; GDSC2 3.5237 6.4253 1.935 8.2058
SU-DHL-8 GDSC1; GDSC2 3.5779 6.2856 2.0477 7.3507
MOLT-4 GDSC1; GDSC2 3.6251 5.1023 2.6701 3.325
MHH-CALL-2 GDSC1; GDSC2 3.7129 7.2046 1.696 9.1887
KY821 GDSC1; GDSC2 3.721 9.7805 0.4189 16.6143
SK-MM-2 GDSC1; GDSC2 3.7453 7.9569 1.3472 11.2402
Farage GDSC1; GDSC2 3.7822 5.8153 2.4349 4.4114
ME1 GDSC1; GDSC2 4.0273 10.6751 0.2154 16.8317
Hs 445 GDSC1; GDSC2 4.2972 15.3962 -1.9229 24.9763
RC-K8 GDSC1; GDSC2 4.388 6.1866 2.6502 1.9758
Karpas-231 GDSC1; GDSC2 4.5536 6.0944 2.7778 1.1207
ROS-50 GDSC1 4.5824 12.3784 -0.2036 20.4131
WSU-DLCL2 GDSC1 4.6817 6.1392 2.8207 1.0043
KM-H2 GDSC1; GDSC2 4.7982 13.6405 -0.6646 18.9739
⏷ Show the Full List of 160 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1 -1.9297 4.6506 -2.8203 59.0431
SK-GT-4 GDSC1; GDSC2 0.9535 6.6831 -0.5886 31.2485
OACM5.1 C GDSC1; GDSC2 1.1353 7.0075 -0.5553 30.3237
FLO-1 GDSC1; GDSC2 1.4366 9.7728 -1.5836 32.7361
OACP4 C GDSC1; GDSC2 1.738 9.0132 -0.9317 29.3764
TE-12 GDSC1; GDSC2 2.3022 9.2733 -0.5412 25.7505
KYAE-1 GDSC1; GDSC2 3.1207 4.8723 2.3732 6.6185
KYSE-220 GDSC1; GDSC2 3.1991 6.7277 1.5156 11.7636
ESO-26 GDSC1; GDSC2 3.211 9.0987 0.3406 18.5299
ESO-51 GDSC1; GDSC2 4.0191 8.0844 1.4938 9.6406
KYSE-50 GDSC1; GDSC2 4.3608 7.2281 2.152 4.8725
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 -0.0006 8.5902 -2.4164 40.717
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-12 GDSC1 -1.8062 11.3325 -5.4795 54.536
NB69 GDSC1; GDSC2 -1.7816 5.4503 -2.9456 50.7764
SJNB-5 GDSC1 -1.5423 6.4838 -3.0911 55.3681
NB1 GDSC1 0.1868 8.9171 -2.3813 44.9908
Kelly GDSC1; GDSC2 0.3525 11.1925 -3.2974 40.687
CHP-212 GDSC1; GDSC2 0.6083 9.8305 -2.3999 38.0848
SK-N-FI GDSC1 0.752 10.0551 -2.3691 42.1925
SK-N-MC-IXC GDSC1 1.075 4.9588 0.2878 32.7134
SJNB-10 GDSC1; GDSC2 1.1273 5.7635 -0.0008 27.9052
CHP-126 GDSC1 1.1994 7.4164 -0.6823 36.0382
SK-N-SH GDSC1 1.3898 6.7928 -0.2035 33.1935
IMR-5 GDSC1; GDSC2 1.6039 7.1644 -0.1683 26.7011
SJNB-13 GDSC1; GDSC2 1.6865 4.2448 1.2214 18.9676
SK-N-DZ GDSC1; GDSC2 1.814 6.0729 0.5509 22.2385
SJNB-7 GDSC1; GDSC2 2.0322 6.5279 0.5487 21.4127
TGW GDSC1; GDSC2 2.2824 7.3598 0.3825 21.3893
SK-N-BE(2)-M17 GDSC1; GDSC2 2.7827 7.0767 0.9782 16.3283
SK-N-AS GDSC1; GDSC2 2.8562 10.9731 -0.8984 25.3763
GI-ME-N GDSC1; GDSC2 2.9314 8.7261 0.2879 19.684
SJNB-14 GDSC1; GDSC2 3.0423 8.4365 0.528 18.0476
SJNB-17 GDSC1 3.1973 8.0159 0.8703 19.0459
GOTO GDSC1; GDSC2 3.4459 7.6836 1.2435 12.7004
NB(TU)1 GDSC1; GDSC2 3.6266 7.1515 1.6547 9.6759
LA-N-6 GDSC1 3.9603 9.7914 0.6026 17.9876
CHP-134 GDSC2 4.0121 7.3309 1.8595 7.4222
KP-N-YN GDSC1; GDSC2 4.1196 6.5928 2.294 4.5212
SiMa GDSC1; GDSC2 4.1263 10.7959 0.2323 16.4801
SJNB-6 GDSC1 4.1505 6.5556 2.3326 5.2585
NH-12 GDSC1; GDSC2 4.4443 14.4655 -1.3444 22.5802
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 0.9149 5.9676 -0.3083 30.2522
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MRK-nu-1 GDSC1; GDSC2 -2.6598 -0.5502 -2.6636 59.8951
MDA-MB-330 GDSC1; GDSC2 -1.0393 3.8544 -1.593 44.9796
OCUB-M GDSC1; GDSC2 -0.9139 1.7797 -0.989 42.7755
CAL-120 GDSC1; GDSC2 -0.6855 4.2309 -1.3296 42.1642
Hs 578T GDSC1; GDSC2 -0.3571 5.141 -1.3036 40.1571
Evsa-T GDSC1; GDSC2 -0.322 5.3359 -1.3416 40.0573
HCC1599 GDSC1 -0.2091 21.0592 -8.6375 48.8059
HCC1500 GDSC1; GDSC2 0.0649 7.9756 -2.07 39.7497
HCC1395 GDSC1 0.2028 10.3871 -3.057 45.5345
MDA-MB-453 GDSC1; GDSC2 0.2831 6.0617 -1.0015 35.8896
UACC-893 GDSC1 0.3212 7.3468 -1.527 43.1074
MDA-MB-361 GDSC1; GDSC2 0.3515 5.7181 -0.7853 34.8104
MDA-MB-468 GDSC1; GDSC2 0.4 3.5813 0.0587 31.0236
HCC1143 GDSC1; GDSC2 0.4775 5.6476 -0.6241 33.5944
MFM-223 GDSC1; GDSC2 0.6189 6.8307 -0.9934 34.2579
BT-20 GDSC1; GDSC2 0.8216 5.037 -0.0109 29.3282
HCC2157 GDSC1; GDSC2 0.9105 6.2506 -0.4378 30.8245
CAL-85-1 GDSC1; GDSC2 0.9239 6.6696 -0.6123 31.4746
HCC1954 GDSC1; GDSC2 1.072 7.1175 -0.669 31.0499
JIMT-1 GDSC1; GDSC2 1.1012 5.6216 0.0344 27.851
MDA-MB-175-VII GDSC1 1.2863 6.6556 -0.2426 33.9207
AU565 GDSC1; GDSC2 1.3863 6.3801 -0.0161 26.8727
T-47D GDSC1; GDSC2 1.4107 11.1123 -2.2617 34.7031
EFM-192A GDSC1; GDSC2 1.4996 7.4852 -0.4219 28.2518
DU4475 GDSC1; GDSC2 1.5647 6.2561 0.2189 24.9797
CAL-51 GDSC1; GDSC2 1.5658 7.7271 -0.4732 28.2067
HCC2218 GDSC1 1.5985 9.9325 -1.5104 36.5555
BT-483 GDSC1 1.6393 8.253 -0.6558 33.6962
MDA-MB-231 GDSC1; GDSC2 1.6949 8.0387 -0.4996 27.8117
HCC202 GDSC1 1.7147 8.0099 -0.4669 32.6069
MDA-MB-415 GDSC1; GDSC2 1.7391 12.8761 -2.8309 34.9111
HDQ-P1 GDSC1; GDSC2 1.7751 8.5191 -0.6564 28.1562
HCC1419 GDSC1; GDSC2 1.9774 7.4801 0.0382 24.2692
CAMA-1 GDSC1; GDSC2 1.9831 8.9351 -0.6658 27.4176
EFM-19 GDSC1; GDSC2 2.0539 11.2858 -1.7605 31.0551
HCC70 GDSC1; GDSC2 2.0994 10.4623 -1.312 29.439
MDA-MB-436 GDSC1; GDSC2 2.1221 12.3513 -2.2278 32.172
HCC1569 GDSC1; GDSC2 2.2076 12.4408 -2.1965 31.8082
HCC1806 GDSC1; GDSC2 2.5416 6.9089 0.8428 17.9277
BT-474 GDSC1; GDSC2 2.8362 7.7312 0.7005 17.7505
COLO 824 GDSC1; GDSC2 3.0291 6.9502 1.2583 13.8636
HCC1937 GDSC1; GDSC2 3.086 11.9433 -1.1869 25.7732
HCC38 GDSC1; GDSC2 3.1389 7.9542 0.8515 15.9296
BT-549 GDSC1; GDSC2 3.2575 9.5453 0.1564 19.3418
HCC1187 GDSC1; GDSC2 3.2681 9.9328 -0.0285 20.2321
MDA-MB-157 GDSC1; GDSC2 3.3061 7.8226 1.0584 14.2154
MCF-7 GDSC1; GDSC2 3.504 9.1747 0.5459 16.5512
HCC1428 GDSC1; GDSC2 4.0079 10.929 0.0738 17.5988
ZR-75-30 GDSC1; GDSC2 5.6273 13.1563 0.1681 13.2328
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 GDSC1 -2.3335 6.5401 -3.9521 59.381
D283 Med GDSC1; GDSC2 -1.8352 6.4303 -3.3799 51.016
KNS-42 GDSC1 -1.2164 9.1681 -3.9032 52.6864
SF126 GDSC1 -1.1372 4.2755 -1.8346 53.8427
MOG-G-UVW GDSC1 -1.1133 2.0394 -1.2382 54.8017
MOG-G-CCM GDSC1 -0.8928 7.4442 -2.8126 51.2963
D-566MG GDSC1 -0.7245 4.3152 -1.4004 50.408
D-423MG GDSC1 -0.4062 3.5605 -0.8142 47.2714
KNS-81-FD GDSC1 -0.3748 5.8289 -1.594 47.6905
SNB-75 GDSC1 -0.307 6.0957 -1.6319 47.2394
YKG-1 GDSC1 -0.2627 5.1764 -1.2164 46.5336
A-172 GDSC1; GDSC2 -0.1482 4.266 -0.7594 37.3422
SW1783 GDSC1 -0.001 4.9219 -0.8395 43.9911
8-MG-BA GDSC1; GDSC2 0.0204 4.536 -0.6728 36.111
42-MG-BA GDSC1; GDSC2 0.0352 6.3882 -1.3982 38.3109
LNZTA3WT4 GDSC1 0.1683 5.0821 -0.7208 42.4953
GaMG GDSC1; GDSC2 0.1713 5.1823 -0.7571 35.621
YH-13 GDSC1; GDSC2 0.229 5.2994 -0.7426 35.2728
SF539 GDSC1; GDSC2 0.2449 4.9272 -0.579 34.5817
GI-1 GDSC1; GDSC2 0.278 7.9876 -1.8615 38.3065
H4 GDSC1; GDSC2 0.2789 6.8392 -1.3433 36.9561
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 0.7443 5.916 -0.4613 31.6801
NMC-G1 GDSC1 0.753 5.0008 -0.0687 36.375
Onda 10 GDSC1 0.8181 5.8389 -0.3518 37.0673
T98G GDSC1; GDSC2 0.8988 5.0699 0.057 28.6493
PFSK-1 GDSC1; GDSC2 0.9928 6.3968 -0.4195 30.3805
D-542MG GDSC1 1.0072 9.397 -1.8091 40.0004
CAS-1 GDSC1; GDSC2 1.0711 8.3708 -1.2578 33.1605
D-247MG GDSC1 1.0772 6.3466 -0.3115 35.3741
KALS-1 GDSC1; GDSC2 1.4155 6.7098 -0.1395 27.3325
D-336MG GDSC1 1.4843 9.6442 -1.4764 36.9835
D-502MG GDSC1 1.5324 7.0774 -0.1968 32.4087
SW1088 GDSC1; GDSC2 1.5557 8.024 -0.6251 28.8789
Hs 683 GDSC1 1.5839 5.1853 0.7213 27.3738
AM-38 GDSC1; GDSC2 1.6045 5.7548 0.4883 23.4114
U-118MG GDSC1; GDSC2 1.7451 6.5838 0.2437 24.1323
Becker GDSC1; GDSC2 1.762 6.7048 0.203 24.2732
M059J GDSC1; GDSC2 1.9951 8.3717 -0.379 26.1501
Onda 11 GDSC1 2.044 8.2265 -0.2626 30.1791
DK-MG GDSC1; GDSC2 2.1246 14.1505 -3.1199 34.3233
ONS-76 GDSC1; GDSC2 2.1824 5.8597 1.012 18.2282
D-392MG GDSC1; GDSC2 2.2534 9.2754 -0.5863 26.1137
SK-MG-1 GDSC1; GDSC2 2.2554 9.3682 -0.6303 26.2919
DBTRG-05MG GDSC1; GDSC2 2.6122 6.0221 1.3428 14.7193
LN-18 GDSC1; GDSC2 2.7917 6.9469 1.0506 15.8719
D-263MG GDSC1; GDSC2 2.8163 5.9901 1.5461 12.7848
U-251MG GDSC1; GDSC2 3.0336 9.3852 0.0468 20.5875
Daoy GDSC1; GDSC2 3.0475 10.7687 -0.6325 23.6777
LN-405 GDSC1; GDSC2 3.1714 10.716 -0.5013 22.7259
GB-1 GDSC1; GDSC2 3.2574 10.078 -0.1101 20.6603
SF268 GDSC1; GDSC2 3.304 11.3961 -0.7301 23.3054
U-87MG ATCC GDSC1; GDSC2 3.3217 6.2799 1.8428 9.3574
LN-229 GDSC1; GDSC2 3.3349 5.6415 2.1729 7.2363
KINGS-1 GDSC1; GDSC2 3.4015 10.4474 -0.1747 20.5345
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 -0.4441 4.255 -1.076 47.8574
TGBC24TKB GDSC1; GDSC2 3.0306 7.2615 1.1044 14.7839
ETK-1 GDSC1; GDSC2 4.0459 9.0714 1.026 12.3497
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1; GDSC2 0.1359 7.4707 -1.7703 38.7529
MFE-280 GDSC1; GDSC2 0.7702 5.1687 -0.1188 30.0698
ESS-1 GDSC1; GDSC2 1.1754 8.1637 -1.0583 32.0559
KLE GDSC1; GDSC2 2.027 12.2415 -2.2582 32.5664
MFE-319 GDSC1; GDSC2 2.2722 4.8753 1.5598 14.632
MFE-296 GDSC1; GDSC2 3.0391 5.2842 2.0962 8.6232
EN GDSC1; GDSC2 3.367 10.2476 -0.1034 20.2969
RL95-2 GDSC1; GDSC2 4.0471 16.7695 -2.8075 28.2356
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 GDSC1 -3.2054 0.5719 -3.2809 74.4641
KTCTL-26A GDSC1 -2.4946 4.4729 -3.3737 62.448
LB1047-RCC GDSC1 -2.3801 4.5387 -3.2711 61.7518
LB2241-RCC GDSC1 -2.225 1.3549 -2.3299 65.9214
KTCTL-1M GDSC1 -2.1536 4.0393 -2.8639 61.0991
BB65-RCC GDSC1 -1.4847 5.9318 -2.8114 55.3431
KTCTL-140 GDSC1 -1.363 5.7933 -2.628 54.6713
CAL-54 GDSC1; GDSC2 -0.912 9.4711 -3.7325 46.3756
KTCTL-21 GDSC1 -0.7951 4.9382 -1.6969 50.9434
Caki-1 GDSC1 -0.6287 7.703 -2.6533 49.7017
KTCTL-13 GDSC1 -0.5523 6.4403 -2.0322 49.1243
KMRC-1 GDSC1 -0.5017 5.6616 -1.6609 48.65
BFTC-909 GDSC1; GDSC2 -0.198 5.1909 -1.1532 38.8626
LB996-RCC GDSC1; GDSC2 -0.1199 10.3329 -3.3457 42.6199
A-498 GDSC1; GDSC2 0.4266 11.9048 -3.5697 40.8036
SW156 GDSC1 0.6957 6.078 -0.5818 38.6048
HA7-RCC GDSC1; GDSC2 0.8572 9.9281 -2.2075 36.6623
ACHN GDSC1; GDSC2 0.8816 8.0325 -1.2833 34.041
TK-10 GDSC1; GDSC2 1.2762 6.1673 -0.0295 27.3999
786-O GDSC1; GDSC2 1.2847 4.382 0.7403 23.3861
KTCTL-195 GDSC1; GDSC2 1.2903 8.0999 -0.9167 31.0765
NCC021 GDSC1 1.3431 10.5037 -2.0271 38.9054
SW13 GDSC1; GDSC2 1.6485 6.587 0.1476 25.0014
RCC10RGB GDSC1; GDSC2 1.6788 10.4825 -1.7055 32.2068
NCC010 GDSC1; GDSC2 1.7164 8.2066 -0.5603 27.9844
RXF 393L GDSC1; GDSC2 1.872 9.5937 -1.0914 29.4691
769-P GDSC1; GDSC2 1.966 6.9573 0.2795 23.0951
A-704 GDSC1; GDSC2 2.2454 8.0489 0.0107 23.4198
KMRC-20 GDSC1; GDSC2 2.5302 6.969 0.8028 18.1966
OS-RC-2 GDSC1; GDSC2 3.1439 8.96 0.3532 18.6699
SN12C GDSC1; GDSC2 3.1511 10.4846 -0.4028 22.3493
VMRC-RCZ GDSC1; GDSC2 3.3573 9.3482 0.3382 18.0991
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LoVo GDSC1; GDSC2 -0.3501 6.1027 -1.68 41.0018
HCT 15 GDSC1; GDSC2 -0.1245 4.5003 -0.8161 37.4057
MDST8 GDSC1; GDSC2 0.0042 5.5007 -1.0612 37.5022
SNU-C1 GDSC1; GDSC2 0.0523 7.3664 -1.8086 39.2415
NCI-H508 GDSC1 0.2823 5.6649 -0.8356 41.9756
NCI-H747 GDSC1; GDSC2 0.3821 4.9925 -0.4584 33.4111
LS411N GDSC1; GDSC2 0.4618 5.6656 -0.6481 33.7625
HCT 116 GDSC1; GDSC2 0.524 6.6979 -1.0305 34.8241
COLO205 GDSC1; GDSC2 1.052 10.1797 -2.1435 35.7479
LS513 GDSC1; GDSC2 1.113 4.6107 0.4683 25.6049
DiFi GDSC1; GDSC2 1.1643 5.2267 0.2694 26.4101
NCI-H716 GDSC1; GDSC2 1.3575 8.6565 -1.1185 31.5282
C2BBe1 GDSC1; GDSC2 1.7058 6.6728 0.1633 24.6952
HCC2998 GDSC1; GDSC2 1.7526 6.5518 0.2661 23.9878
CaR-1 GDSC1; GDSC2 1.847 5.471 0.8613 20.379
LS123 GDSC1; GDSC2 1.9146 11.5029 -1.9934 32.2166
LS180 GDSC1; GDSC2 1.9811 6.1721 0.6683 20.9468
SNU-407 GDSC1; GDSC2 2.1011 9.0254 -0.6018 26.7226
SNU-175 GDSC2 2.2454 8.5958 -0.2584 24.6965
SNU-81 GDSC1; GDSC2 2.2732 9.0192 -0.4418 25.4216
CL-11 GDSC1; GDSC2 2.2975 9.6148 -0.7142 26.4917
SNU-C5 GDSC1; GDSC2 2.4253 8.3049 0.0487 22.5963
SW48 GDSC1; GDSC2 2.4922 8.4878 0.0187 22.5123
RKO GDSC1; GDSC2 2.51 9.5186 -0.4766 24.7534
HT-55 GDSC1; GDSC2 2.5806 8.7473 -0.0309 22.4529
SW948 GDSC1; GDSC2 2.6116 7.4706 0.6295 18.8962
SW620 GDSC1; GDSC2 2.709 6.3825 1.255 14.9226
GP5d GDSC1; GDSC2 3.0032 7.7698 0.8271 16.4943
SW626 GDSC1; GDSC2 3.0556 13.1017 -1.7916 27.9638
HT115 GDSC1; GDSC2 3.1885 7.9462 0.8977 15.5103
CCK-81 GDSC1; GDSC2 3.221 8.6614 0.5676 17.2764
SNU-C2B GDSC1; GDSC2 3.2399 9.4023 0.2131 19.1049
T84 GDSC1; GDSC2 3.2743 6.9779 1.4541 11.9178
HT-29 GDSC1; GDSC2 3.3631 10.9122 -0.4389 21.8674
SW1463 GDSC1; GDSC2 3.5587 6.623 1.8643 8.5536
LS1034 GDSC1; GDSC2 3.5912 7.1378 1.6335 9.9041
SW837 GDSC1; GDSC2 3.6153 6.2586 2.0903 6.9831
SK-CO-1 GDSC1; GDSC2 3.666 10.655 -0.0619 19.2204
COLO 320HSR GDSC1; GDSC2 3.7242 6.5721 2.0187 7.149
SW1116 GDSC1; GDSC2 3.7761 7.5567 1.5701 9.7989
CW-2 GDSC1; GDSC2 4.1704 8.4157 1.4429 9.5741
SNU-1040 GDSC1; GDSC2 4.5222 15.2435 -1.6705 23.5562
RCM-1 [Human ESC] GDSC1; GDSC2 4.5672 9.729 1.0875 10.7126
SNU-61 GDSC1; GDSC2 4.8286 8.6277 1.795 6.0416
KM12 GDSC1; GDSC2 5.1343 6.9476 2.7052 0.8735
COLO 678 GDSC1; GDSC2 5.5369 13.9342 -0.2708 15.5061
SW1417 GDSC1; GDSC2 5.9383 15.4777 -0.7377 16.6815
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 3.7277 6.4647 2.0745 6.7908
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuH-1 GDSC1; GDSC2 -0.2248 5.359 -1.2474 39.2723
JHH-2 GDSC1; GDSC2 -0.1651 6.2284 -1.5389 39.6988
HLE GDSC1; GDSC2 0.3236 8.7168 -2.1529 38.758
Hep 3B2.1-7 GDSC1; GDSC2 0.4126 6.9028 -1.2352 35.9996
JHH-6 GDSC1; GDSC2 0.5889 7.8739 -1.4989 35.9656
SNU-423 GDSC1; GDSC2 0.6644 9.5542 -2.2141 37.4524
JHH-4 GDSC1; GDSC2 1.22 7.2721 -0.5946 30.1238
SNU-398 GDSC1; GDSC2 1.2876 8.7778 -1.2436 32.2333
SK-HEP-1 GDSC1; GDSC2 1.5904 5.4253 0.6221 22.7438
SNU-449 GDSC1; GDSC2 1.7269 6.1934 0.4087 23.3445
SNU-387 GDSC1; GDSC2 2.23 9.4573 -0.6973 26.6592
Hep-G2/C3A GDSC1; GDSC2 2.5696 9.0025 -0.1674 23.145
Huh-7 GDSC1; GDSC2 3.348 7.429 1.29 12.7036
JHH-1 GDSC1; GDSC2 3.8606 17.3198 -3.2333 29.7898
JHH-7 GDSC1; GDSC2 5.0173 16.9846 -2.1531 23.9633
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 177 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H292 GDSC1 -5.4808 5.8333 -7.0713 70.9122
NCI-H2030 GDSC1 -2.8651 2.7983 -3.2947 67.1801
SBC-1 GDSC1 -2.5233 2.1448 -2.7786 66.4908
NCI-H1648 GDSC1 -2.3839 2.4788 -2.6967 64.9499
NCI-H838 GDSC1 -2.3589 4.8114 -3.34 61.2991
NCI-H647 GDSC1 -2.1033 1.0163 -2.1641 65.5183
COR-L32 GDSC1 -2.0748 7.5392 -4.0835 57.4161
COR-L279 GDSC1 -1.7432 3.8278 -2.3518 58.6844
NCI-H290 GDSC1 -1.5719 2.9659 -1.926 58.3
NCI-H1341 GDSC1 -1.4627 1.7073 -1.5638 58.6066
A-549 GDSC1; GDSC2 -1.3946 3.7938 -1.9616 47.9091
CAL-12T GDSC1 -1.3778 3.2762 -1.7946 56.4209
NCI-H2347 GDSC1 -1.358 7.8518 -3.4693 53.7664
NCI-H2023 GDSC1; GDSC2 -1.2406 4.4872 -2.0181 46.8747
NCI-H1876 GDSC1; GDSC2 -1.1933 3.3128 -1.6032 46.075
NCI-H2342 GDSC1 -1.1192 7.1001 -2.901 52.6937
NCI-H460 GDSC1 -1.0652 10.7217 -4.4596 51.7244
EMC-BAC-2 GDSC1; GDSC2 -0.7935 5.4705 -1.8961 43.9042
NCI-H1944 GDSC1; GDSC2 -0.752 5.2323 -1.7605 43.4338
NCI-H2122 GDSC1; GDSC2 -0.6848 3.2368 -1.0278 41.3867
RERF-LC-MS GDSC1 -0.6828 3.0829 -0.9856 50.0483
NCI-H69 GDSC1 -0.6437 5.0618 -1.5802 49.7218
NCI-H2373 GDSC1; GDSC2 -0.4496 7.6618 -2.4517 42.8943
SBC-3 GDSC1; GDSC2 -0.4254 4.3925 -1.103 40.0118
Calu-3 GDSC1; GDSC2 -0.411 5.2256 -1.3937 40.6867
EPLC-272H GDSC1; GDSC2 -0.4035 7.3294 -2.2583 42.3641
NCI-H2461 GDSC1; GDSC2 -0.398 6.3087 -1.8159 41.5396
NCI-H1437 GDSC1 -0.3466 4.0318 -0.8958 46.8411
NCI-H1581 GDSC1; GDSC2 -0.2941 6.629 -1.8428 41.0461
DMS 273 GDSC1; GDSC2 -0.2787 9.8576 -3.2792 43.2017
NCI-H1975 GDSC1; GDSC2 -0.2573 5.2301 -1.2315 39.4081
NCI-H1703 GDSC1 -0.2168 6.4327 -1.6789 46.6662
NCI-H847 GDSC1 -0.1697 6.2961 -1.5721 46.2486
SK-LU-1 GDSC1; GDSC2 -0.1641 7.5093 -2.0926 40.8848
NCI-H2795 GDSC1; GDSC2 -0.128 7.4829 -2.044 40.6147
NCI-H2009 GDSC1 -0.0057 5.8032 -1.195 44.6465
NCI-H2110 GDSC1 0.0927 6.674 -1.4621 44.399
NCI-H1793 GDSC1; GDSC2 0.1089 5.541 -0.967 36.6584
COR-L105 GDSC1; GDSC2 0.1229 6.8207 -1.4951 38.1309
SBC-5 GDSC1; GDSC2 0.2203 3.736 -0.1845 33.0659
EMC-BAC-1 GDSC1 0.3232 6.221 -1.0282 42.1424
LB647-SCLC GDSC1 0.4905 4.6237 -0.2006 38.6464
NCI-H1770 GDSC1 0.5168 7.5756 -1.4339 41.8078
NCI-H209 GDSC1; GDSC2 0.519 6.8502 -1.1035 35.0868
NCI-H596 GDSC1; GDSC2 0.5394 8.4177 -1.8004 36.992
NCI-H1993 GDSC1; GDSC2 0.5524 10.5121 -2.7796 39.0546
NCI-H3122 GDSC1; GDSC2 0.5549 5.7153 -0.5719 33.018
NCI-H1666 GDSC1; GDSC2 0.5631 7.3501 -1.2845 35.4515
PC-14 GDSC1; GDSC2 0.5652 5.4708 -0.4587 32.5151
Lu-139 GDSC1; GDSC2 0.573 9.2364 -2.1521 37.6899
ChaGo-K-1 GDSC1 0.613 7.662 -1.3773 41.1505
NCI-H2228 GDSC1; GDSC2 0.6197 6.655 -0.9139 33.98
NCI-H1623 GDSC1; GDSC2 0.6378 5.6616 -0.4628 32.1852
LXF 289 GDSC1; GDSC2 0.6642 5.328 -0.2956 31.356
IST-SL1 GDSC1 0.6861 7.2098 -1.097 40.0982
NCI-H446 GDSC1; GDSC2 0.7038 8.3529 -1.6082 35.769
NCI-H1155 GDSC1; GDSC2 0.761 5.0417 -0.0767 29.9183
NCI-H2731 GDSC1; GDSC2 0.7779 8.151 -1.4407 34.9691
NCI-H146 GDSC1 0.8766 6.6303 -0.6423 37.7114
NCI-H1436 GDSC1 0.9098 8.0001 -1.2405 39.2158
PaCa-3 GDSC1 0.9282 7.0356 -0.7747 37.8297
RERF-LC-Sq1 GDSC1; GDSC2 0.9612 5.821 -0.1966 29.5496
UMC-11 GDSC1; GDSC2 0.9642 5.6304 -0.1108 29.1448
Lu-65 GDSC1; GDSC2 1.0221 8.543 -1.387 33.7742
NCI-H2818 GDSC1; GDSC2 1.0835 8.8424 -1.4703 33.7786
BEN GDSC1 1.0911 17.2997 -5.6032 44.1728
LC-2/ad GDSC1 1.0951 6.7052 -0.4564 35.8185
NCI-H520 GDSC1; GDSC2 1.1008 7.6136 -0.8716 31.6973
NCI-H2085 GDSC1; GDSC2 1.104 5.1017 0.2591 26.7281
Lu-99A GDSC1; GDSC2 1.1298 8.925 -1.4653 33.5756
NCI-H524 GDSC1; GDSC2 1.16 7.2166 -0.6279 30.5112
NCI-H1573 GDSC1 1.1753 5.2277 0.2804 32.1531
NCI-H2869 GDSC1; GDSC2 1.2268 7.5735 -0.7292 30.6288
COR-L88 GDSC1 1.2726 9.4556 -1.5844 38.2386
NCI-H2803 GDSC1; GDSC2 1.3297 7.4912 -0.5899 29.6478
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 1.3529 6.3217 -0.0227 27.044
NCI-H211 GDSC1; GDSC2 1.416 9.2579 -1.3531 32.0891
NCI-H1355 GDSC1; GDSC2 1.4483 12.7476 -3.0308 36.2995
NCI-H2591 GDSC1; GDSC2 1.4599 9.4166 -1.3886 32.0349
HCC44 GDSC1; GDSC2 1.4661 6.7339 -0.1007 26.9433
NCI-H1299 GDSC1; GDSC2 1.4703 7.6141 -0.5114 28.7502
CPC-N GDSC1; GDSC2 1.4715 10.0496 -1.6858 32.9118
NCI-H2170 GDSC1; GDSC2 1.5081 7.1655 -0.2621 27.5138
NCI-H1568 GDSC1; GDSC2 1.5102 11.5554 -2.3875 34.6585
NCI-H1755 GDSC1; GDSC2 1.5956 10.8528 -1.9638 33.2533
LOU-NH91 GDSC1; GDSC2 1.6628 6.686 0.1151 25.1062
NCI-H1693 GDSC2 1.6663 10.4433 -1.6978 32.2292
NCI-H1781 GDSC1; GDSC2 1.6759 6.2912 0.3128 24.0504
NCI-H2804 GDSC1; GDSC2 1.7126 12.9434 -2.888 35.1235
NCI-H82 GDSC1; GDSC2 1.7213 7.6565 -0.2903 26.7945
NCI-H358 GDSC1; GDSC2 1.82 6.8922 0.1702 24.2133
SK-MES-1 GDSC1; GDSC2 1.8206 5.503 0.8202 20.7162
NCI-H1792 GDSC1; GDSC2 1.8668 6.7375 0.2892 23.4239
NCI-H2172 GDSC1 1.897 7.5535 -0.0735 30.0183
NCI-H1915 GDSC1; GDSC2 2.0034 9.4948 -0.9221 28.3599
NCI-H2444 GDSC1 2.0629 8.6702 -0.4623 30.9444
NCI-H513 GDSC1; GDSC2 2.1098 6.2122 0.7741 19.8679
NCI-H2810 GDSC1; GDSC2 2.1295 9.0279 -0.577 26.5158
HCC78 GDSC1; GDSC2 2.1552 9.5773 -0.8243 27.4354
HOP-92 GDSC1; GDSC2 2.1883 10.0521 -1.029 28.1083
NCI-H720 GDSC1; GDSC2 2.1966 9.195 -0.5981 26.3649
COR-L321 GDSC1 2.202 10.4838 -1.2304 33.1353
NCI-H841 GDSC1; GDSC2 2.2626 8.6027 -0.246 24.5785
NCI-H1048 GDSC1; GDSC2 2.2801 7.0916 0.5113 20.7054
Lu-134-A GDSC1 2.3284 9.5001 -0.6298 30.451
EKVX GDSC1; GDSC2 2.341 10.6083 -1.1678 28.096
NCI-H1836 GDSC1 2.3973 16.097 -3.8516 38.2891
NCI-H1869 GDSC1; GDSC2 2.4004 10.4382 -1.0307 27.3853
IA-LM GDSC1; GDSC2 2.4325 11.4417 -1.5011 28.9559
SW1271 GDSC1; GDSC2 2.4434 8.6657 -0.1132 23.3203
NCI-H835 GDSC1 2.4688 8.6272 -0.0714 27.3862
IST-SL2 GDSC1; GDSC2 2.4734 6.8963 0.7863 18.4878
NCI-H2291 GDSC1 2.51 11.4054 -1.4149 32.4866
NCI-H3255 GDSC1; GDSC2 2.5349 8.2863 0.1567 21.6757
NCI-H2722 GDSC1; GDSC2 2.5593 12.2365 -1.7858 29.4706
EBC-1 GDSC1; GDSC2 2.6597 8.2423 0.2902 20.565
NCI-H810 GDSC1; GDSC2 2.6697 9.3187 -0.2359 23.1292
NCI-H250 GDSC2 2.6878 10.4179 -0.7675 25.3914
NCI-H2405 GDSC1; GDSC2 2.7559 10.4386 -0.7185 24.9676
NCI-H650 GDSC1; GDSC2 2.7839 7.5017 0.7683 17.538
NCI-H526 GDSC1; GDSC2 2.8029 7.1084 0.9805 16.2485
RERF-LC-KJ GDSC1; GDSC2 2.8278 15.2352 -3.0513 32.1024
HOP-62 GDSC1; GDSC2 2.832 7.2134 0.9542 16.3067
NCI-H1694 GDSC1; GDSC2 2.8336 8.0633 0.5329 18.6903
HCC366 GDSC1; GDSC2 2.8531 8.1881 0.4879 18.8718
KNS-62 GDSC1; GDSC2 2.8764 10.886 -0.8375 25.0679
A-427 GDSC1; GDSC2 2.9174 9.9544 -0.3371 22.7864
NCI-H322M GDSC1; GDSC2 2.9176 11.3944 -1.056 25.7979
HCC827 GDSC1; GDSC2 2.944 7.0135 1.1524 14.7715
DMS 114 GDSC1; GDSC2 2.9516 7.0299 1.151 14.7557
COR-L23 GDSC1; GDSC2 2.9892 8.1125 0.644 17.5753
Calu-6 GDSC1; GDSC2 2.9922 9.9922 -0.2918 22.3405
SHP-77 GDSC1; GDSC2 3.0047 7.571 0.9276 15.9082
HCC15 GDSC1; GDSC2 3.1178 7.2111 1.2047 13.9117
Ms-1 GDSC1; GDSC2 3.149 7.9899 0.8423 15.9518
Lu-135 GDSC1; GDSC2 3.1574 8.675 0.5071 17.8029
NCI-H1838 GDSC1 3.1963 8.318 0.7184 20.0154
SW1573 GDSC1; GDSC2 3.2543 11.733 -0.9401 24.3119
LCLC-97TM1 GDSC1; GDSC2 3.3563 8.3265 0.8482 15.2913
VMRC-LCD GDSC1; GDSC2 3.3769 10.1261 -0.0345 19.9327
LK-2 GDSC1; GDSC2 3.4743 5.5565 2.3289 5.8578
NCI-H1105 GDSC1 3.5041 10.0266 0.1202 22.3139
LC-1/sq GDSC1; GDSC2 3.5079 8.4649 0.9037 14.5284
NCI-H1563 GDSC1; GDSC2 3.5169 14.8868 -2.2989 28.2037
NCI-H2087 GDSC1; GDSC2 3.5591 7.3718 1.4911 10.8719
NCI-H2066 GDSC1 3.598 10.9973 -0.2882 24.0289
NCI-H661 GDSC1; GDSC2 3.6023 6.1581 2.1302 6.767
NCI-H2369 GDSC1; GDSC2 3.6116 9.7607 0.3406 17.34
NCI-H226 GDSC1; GDSC2 3.6348 15.6253 -2.5711 28.6591
NCI-H345 GDSC1; GDSC2 3.6348 7.8388 1.3186 11.7144
DMS 79 GDSC1; GDSC2 3.6468 8.8888 0.8044 14.7013
Lu-165 GDSC1; GDSC2 3.6492 7.9197 1.2898 11.8481
NCI-H1650 GDSC1; GDSC2 3.6527 8.5535 0.9764 13.6965
ABC-1 GDSC1; GDSC2 3.7054 9.4525 0.5701 15.8427
DMS 53 GDSC1; GDSC2 3.7413 6.7023 1.9672 7.4267
LCLC-103H GDSC1; GDSC2 3.7841 11.1319 -0.2049 19.5695
NCI-H1651 GDSC1; GDSC2 3.8561 13.4371 -1.2977 23.9611
NCI-H2081 GDSC1 3.8665 8.6024 1.1207 14.9792
NCI-H1688 GDSC1 4.058 9.5076 0.8191 16.3265
COR-L95 GDSC1 4.0633 9.7367 0.7095 16.9949
COLO 668 GDSC1; GDSC2 4.0778 11.0857 0.0506 17.5248
NCI-H23 GDSC1; GDSC2 4.1076 6.2771 2.4367 3.6898
NCI-H2227 GDSC1; GDSC2 4.1772 14.3222 -1.4827 23.7761
NCI-H187 GDSC1 4.1833 8.4997 1.4111 11.9542
NCI-H196 GDSC1; GDSC2 4.2325 14.1222 -1.3394 23.1082
COR-L311 GDSC2 4.2747 6.7647 2.3151 4.0776
NCI-H2595 GDSC1; GDSC2 4.3781 14.5814 -1.4536 23.1507
NCI-H522 GDSC1; GDSC2 4.4864 12.6988 -0.4349 18.7461
NCI-H1304 GDSC1 4.5241 9.7769 1.0333 13.5047
NCI-H2029 GDSC1; GDSC2 4.563 9.0121 1.433 8.7167
NCI-H1435 GDSC1; GDSC2 4.6729 12.6808 -0.2849 17.5932
NCI-H1092 GDSC1; GDSC2 4.8601 13.4241 -0.5116 18.157
NCI-H2135 GDSC1; GDSC2 4.9609 6.6931 2.7276 0.9323
NCI-H727 GDSC1; GDSC2 5.6735 13.6593 -0.0425 14.1476
NCI-H1963 GDSC2 5.682 7.4518 2.7424 0.4205
NCI-H441 GDSC1; GDSC2 5.9293 16.959 -1.4647 19.5577
NCI-H2141 GDSC1; GDSC2 6.0824 13.9863 0.0777 12.7304
⏷ Show the Full List of 177 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 -1.1352 4.7029 -1.9788 46.1353
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-510 GDSC1 -0.8009 2.9302 -1.0769 51.2695
T.T GDSC1 -0.3086 4.6516 -1.0689 46.7273
OE33 GDSC1; GDSC2 -0.2587 8.5802 -2.6703 42.3076
TE-10 GDSC1 -0.0511 4.976 -0.9136 44.5043
OE21 GDSC1; GDSC2 0.1378 5.7455 -1.0205 36.6822
TE-11 GDSC1 0.4034 4.4649 -0.2349 39.3802
KYSE-150 GDSC1 0.471 5.5734 -0.6 40.0945
KYSE-140 GDSC1; GDSC2 0.6771 5.8588 -0.5062 32.1767
EC-GI-10 GDSC1; GDSC2 0.6775 7.2047 -1.1034 34.3585
TE-5 GDSC1; GDSC2 1.5485 7.6326 -0.4448 28.154
KYSE-180 GDSC1; GDSC2 1.8212 9.2893 -0.9892 29.2805
TE-15 GDSC1; GDSC2 1.8424 8.5892 -0.6275 27.783
KYSE-520 GDSC1; GDSC2 1.8594 10.497 -1.5471 31.0671
KYSE-410 GDSC1; GDSC2 2.0511 6.4698 0.5947 21.0898
TE-6 GDSC1; GDSC2 2.0986 8.0686 -0.1348 24.6521
KYSE-450 GDSC1; GDSC2 2.1019 6.3201 0.7151 20.2303
OE19 GDSC1; GDSC2 2.118 12.0604 -2.0871 31.7972
KYSE-270 GDSC1; GDSC2 2.1558 5.816 1.0068 18.3576
TE-9 GDSC1; GDSC2 2.2466 6.5221 0.7563 19.4649
KYSE-70 GDSC1; GDSC2 2.7655 8.7098 0.1513 20.9277
COLO 680N GDSC1; GDSC2 3.0374 9.6244 -0.0695 21.1462
TE-4 GDSC1; GDSC2 3.323 8.9715 0.4981 17.3469
TE-8 GDSC1; GDSC2 3.5045 10.512 -0.1222 19.9794
TE-1 GDSC1; GDSC2 3.6593 6.6122 1.9488 7.7553
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC1; GDSC2 -2.076 2.0531 -2.2774 53.616
OC 314 GDSC1 -1.316 1.8867 -1.4322 56.9851
OVCAR-4 GDSC1; GDSC2 -0.9457 13.9687 -5.8728 47.4812
JHOS-2 GDSC1 -0.7782 5.9611 -2.0733 50.7173
JHOS-4 GDSC1 -0.5871 7.7553 -2.6337 49.4511
TOV-112D GDSC1; GDSC2 -0.3798 10.2294 -3.5524 43.9279
TOV-21G GDSC1; GDSC2 -0.2422 3.9574 -0.7581 37.8672
RMG-I GDSC1 -0.0237 5.4158 -1.0566 44.55
OVCAR-5 GDSC1; GDSC2 0.0757 7.1032 -1.6678 38.7969
TYK-nu GDSC1; GDSC2 0.3272 4.7749 -0.4326 33.5814
DOV13 GDSC1; GDSC2 0.3656 5.8782 -0.8378 34.927
OAW42 GDSC1; GDSC2 0.4956 8.4434 -1.8557 37.3212
EFO-27 GDSC1; GDSC2 0.4982 11.4389 -3.277 40.1053
OVK18 GDSC1; GDSC2 1.1644 9.0819 -1.5074 33.5653
OVTOKO GDSC1; GDSC2 1.5097 9.2457 -1.2589 31.4147
OVCAR-8 GDSC1; GDSC2 1.8065 7.4269 -0.0986 25.58
FU-OV-1 GDSC1 2.1152 12.2466 -2.1821 36.0927
EFO-21 GDSC1; GDSC2 2.1334 8.9308 -0.5256 26.2835
ES-2 GDSC1; GDSC2 2.4084 7.4477 0.4557 20.5499
OVCAR-3 GDSC1; GDSC2 2.5721 11.625 -1.4699 28.396
Caov-4 GDSC1 2.6499 9.2015 -0.1951 27.2084
OV-90 GDSC1; GDSC2 3.2006 6.7824 1.4896 11.9201
OAW28 GDSC1; GDSC2 3.2171 10.9959 -0.6028 23.0279
OVKATE GDSC1 3.3214 10.459 -0.2471 24.8286
OVISE GDSC1; GDSC2 3.3425 12.6461 -1.323 25.5091
OV56 GDSC1; GDSC2 3.5008 5.4102 2.4229 5.1929
SK-OV-3 GDSC1; GDSC2 3.7034 13.3565 -1.3811 24.6898
Kuramochi GDSC1; GDSC2 3.8035 12.4548 -0.8496 22.356
IGROV-1 GDSC1; GDSC2 3.8384 7.7384 1.528 9.894
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 04.03 GDSC1 -1.7118 4.2666 -2.4558 58.0324
MZ-PC-1 GDSC1 -0.7271 4.3539 -1.4163 50.4285
DAN-G GDSC1; GDSC2 -0.4524 4.8299 -1.2888 40.6651
Panc 03.27 GDSC1 -0.2367 3.8973 -0.7328 45.6668
SW1990 GDSC1 0.1354 4.9832 -0.7174 42.7242
HPAF-II GDSC1; GDSC2 0.1956 4.2977 -0.3986 34.1159
Hs 766T GDSC1 0.3817 6.7249 -1.1878 42.1113
PL4 GDSC1; GDSC2 0.6182 4.1307 0.1166 29.6754
Panc 02.03 GDSC1; GDSC2 1.0711 7.1388 -0.6798 31.0961
KP-4 GDSC1; GDSC2 1.4076 6.4359 -0.0205 26.805
Panc 08.13 GDSC1; GDSC2 1.421 9.9632 -1.6909 33.1172
PaTu 8988t GDSC1; GDSC2 1.6557 9.6821 -1.3349 31.1171
Panc 10.05 GDSC1; GDSC2 1.7354 12.0375 -2.4196 33.9589
BxPC-3 GDSC1; GDSC2 1.8404 8.044 -0.3643 26.6661
KP-1N GDSC1; GDSC2 1.8543 8.3558 -0.5027 27.215
MIA PaCa-2 GDSC1; GDSC2 2.1651 8.0148 -0.0467 23.9891
PaTu 8902 GDSC1; GDSC2 2.1831 9.4338 -0.7282 26.9512
HPAC GDSC1; GDSC2 2.7553 9.3472 -0.1751 22.5607
Capan-2 GDSC2 2.7935 11.5601 -1.2454 26.8972
SUIT-2 GDSC1; GDSC2 3.043 6.1366 1.6759 11.2473
CFPAC-1 GDSC1; GDSC2 3.184 10.47 -0.3677 22.0895
PSN1 GDSC1; GDSC2 3.2113 9.7312 0.0246 20.144
HuP-T4 GDSC1; GDSC2 3.4561 8.9784 0.6047 16.3687
SU.86.86 GDSC1; GDSC2 3.4638 8.8115 0.6944 15.8469
HuP-T3 GDSC1; GDSC2 3.6078 7.0649 1.683 9.5519
KP-3 GDSC1; GDSC2 3.809 10.2833 0.2384 17.3129
Capan-1 GDSC1; GDSC2 3.9336 9.5906 0.6817 14.5997
YAPC GDSC1; GDSC2 4.2582 14.664 -1.5889 23.9428
QGP-1 GDSC1; GDSC2 4.7595 13.5614 -0.6546 19.0262
KP-2 GDSC1; GDSC2 4.8189 14.3905 -1.0197 20.393
AsPC-1 GDSC2 6.2813 15.8307 -0.6711 15.6884
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 GDSC1 -2.3321 3.1946 -2.8142 63.3997
MSTO-211H GDSC1; GDSC2 -0.8398 4.071 -1.4445 43.3898
NCI-H28 GDSC1; GDSC2 1.4582 11.9258 -2.6172 35.38
MPP 89 GDSC1; GDSC2 2.0749 8.264 -0.2523 25.2854
IST-Mes1 GDSC1; GDSC2 2.4205 10.7748 -1.18 27.8728
NCI-H2052 GDSC2 4.9615 14.2437 -0.84 19.3165
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1; GDSC2 -1.0058 4.4119 -1.738 44.9793
22Rv1 GDSC1; GDSC2 -0.7321 5.5156 -1.8482 43.4656
PC-3 GDSC1; GDSC2 -0.1992 7.371 -2.0672 41.0085
DU145 GDSC1; GDSC2 2.8231 15.5014 -3.1883 32.4322
VCaP GDSC1; GDSC2 3.1825 8.4634 0.6341 17.0266
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 0.9574 5.2441 0.0463 28.4348
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-MEL-2 GDSC1 -3.9604 1.5142 -4.215 75.2364
IPC-298 GDSC1 -1.7121 4.3814 -2.4938 57.9264
COLO 800 GDSC1 -1.6754 2.6932 -1.9738 59.4422
Mel Ho GDSC1 -1.1829 2.4283 -1.3823 55.2803
MeWo GDSC1 -1.1128 7.3627 -3.0056 52.5874
IST-MEL1 GDSC1 -1.0703 3.4543 -1.5082 53.6683
A-431 GDSC1 -0.9325 5.4343 -2.0304 51.9012
MMAc-SF GDSC1 -0.8108 5.8082 -2.0467 50.9635
MZ-MEL-7 GDSC1 -0.7752 4.2422 -1.4308 50.8553
LOX-IMVI GDSC1; GDSC2 -0.6231 2.651 -0.8205 40.3513
WM35 GDSC1 -0.5428 4.6629 -1.3254 48.8371
CP50-MEL-B GDSC1 -0.4646 4.7501 -1.2727 48.167
A101D GDSC1; GDSC2 -0.3798 5.0044 -1.276 40.2148
IGR-37 GDSC1; GDSC2 -0.3484 3.7994 -0.8235 38.7024
451Lu GDSC1 -0.3096 3.802 -0.7821 46.3706
RVH-421 GDSC1 -0.1553 5.0026 -1.0351 45.4868
SK-MEL-28 GDSC1 -0.1031 9.1341 -2.7694 46.8215
A-388 GDSC1 0.0294 6.7131 -1.5443 44.9158
RPMI-7951 GDSC1; GDSC2 0.1677 6.3789 -1.257 37.2514
DJM-1 GDSC1 0.1967 6.5034 -1.2808 43.4458
Hs 938.T GDSC1 0.2549 5.9723 -0.993 42.512
SK-MEL-30 GDSC1 0.3363 3.2791 0.0752 38.6399
G-mel GDSC1; GDSC2 0.3797 4.999 -0.4635 33.4437
CP66-MEL GDSC1; GDSC2 0.4937 5.1869 -0.4176 32.6925
SH-4 GDSC1; GDSC2 0.559 6.3976 -0.862 34.0812
SK-MEL-2 GDSC1; GDSC2 0.7249 4.9113 -0.0625 30.0217
A-375 GDSC1; GDSC2 0.9683 4.9751 0.1689 27.7866
M14 GDSC1; GDSC2 0.9708 6.2367 -0.3702 30.2686
Hs 940.T GDSC1 1.0674 7.4599 -0.8327 37.2364
GAK GDSC1; GDSC2 1.0731 5.4624 0.0741 27.7832
HMV-II GDSC1; GDSC2 1.1234 8.1195 -1.0879 32.3743
WM1552C GDSC1; GDSC2 1.1445 4.9656 0.358 26.0422
WM115 GDSC1; GDSC2 1.2741 7.5318 -0.6633 30.1734
A2058 GDSC2 1.3042 5.5248 0.2853 25.7251
SK-MEL-5 GDSC1; GDSC2 1.3807 7.6825 -0.6308 29.6044
SK-MEL-3 GDSC1 1.4651 7.5221 -0.4728 33.8842
HT-144 GDSC1; GDSC2 1.4822 7.4218 -0.4086 28.2643
WM793 GDSC1; GDSC2 1.4962 5.4991 0.4932 23.8294
CHL-1 GDSC1; GDSC2 1.5362 6.7492 -0.0387 26.3643
COLO 783 GDSC1 1.6655 7.9682 -0.4935 32.9531
SK-MEL-1 GDSC1 1.688 8.7723 -0.8613 34.1884
UACC-62 GDSC1; GDSC2 1.705 7.9497 -0.447 27.5479
G-361 GDSC1; GDSC2 2.0209 9.0148 -0.6702 27.2975
COLO 679 GDSC1; GDSC2 2.277 6.6068 0.744 19.4246
IGR-1 GDSC1; GDSC2 2.5444 4.8619 1.8362 11.9399
SK-MEL-24 GDSC1; GDSC2 2.7391 9.3471 -0.1891 22.6802
WT2-iPS GDSC1; GDSC2 2.8574 10.4386 -0.6306 24.2711
COLO 829 GDSC1; GDSC2 3.0323 9.7085 -0.1158 21.3856
Mel JuSo GDSC1; GDSC2 3.0833 7.743 0.9095 15.7667
SK-MEL-31 GDSC1 3.1591 13.4429 -1.8748 31.5292
LB373-MEL-D GDSC1 3.3542 10.7356 -0.3581 25.2279
UACC-257 GDSC1; GDSC2 3.3576 12.1963 -1.0856 24.5749
WM278 GDSC1; GDSC2 3.4862 8.4042 0.9163 14.5182
LB2518-MEL GDSC1 3.5637 16.0561 -2.8448 32.7853
VMRC-MELG GDSC1 3.7277 8.9989 0.8142 17.4678
COLO 792 GDSC1; GDSC2 4.025 8.7607 1.164 11.5976
EquiPSC Line K2 GDSC1 0.1227 7.054 -1.598 44.4071
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 0.4409 6.3104 -0.9453 34.9324
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 633.T GDSC1 -2.598 0.4078 -2.6336 70.8427
Rh41 GDSC1; GDSC2 -2.2352 1.9902 -2.438 54.9528
G-402 GDSC1; GDSC2 -1.719 2.8673 -2.0622 50.4875
STS-0421 GDSC1 -1.6549 5.5478 -2.8461 56.6104
SK-LMS-1 GDSC1; GDSC2 -1.4779 4.8908 -2.4153 48.7242
KYM-1 GDSC1; GDSC2 -0.549 4.859 -1.4034 41.508
MFH-ino GDSC1 -0.5182 4.5111 -1.2449 48.5953
EW-8 GDSC1; GDSC2 0.0803 3.2842 -0.2055 33.8894
G-401 GDSC1; GDSC2 0.7962 7.4929 -1.1168 33.8727
SW982 GDSC1; GDSC2 1.3483 6.7324 -0.2165 27.9645
VA-ES-BJ GDSC1; GDSC2 1.5366 6.8418 -0.0818 26.5672
MES-SA GDSC1; GDSC2 1.6756 10.2853 -1.6117 31.9328
RKN GDSC1; GDSC2 1.7951 4.6303 1.1785 18.7631
A-204 GDSC1; GDSC2 1.9641 7.617 -0.0408 24.7034
SW872 GDSC1; GDSC2 2.7363 9.5536 -0.2945 23.1795
Rh30 GDSC1; GDSC2 2.7646 8.5582 0.226 20.5482
SK-UT-1 GDSC1; GDSC2 2.7863 6.442 1.2957 14.4184
Rh18 GDSC1 2.8425 11.1482 -0.9976 29.7868
GCT GDSC1; GDSC2 3.025 9.4462 0.009 20.8016
RD GDSC1; GDSC2 3.3265 10.0057 -0.0161 19.9941
HT-1080 GDSC1; GDSC2 3.375 6.7479 1.653 10.3911
SW684 GDSC1; GDSC2 4.1606 11.758 -0.2192 18.6052
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Fu97 GDSC1 -2.4378 2.541 -2.7691 65.1834
TMK-1 GDSC1 -2.0861 2.4723 -2.3716 62.9093
23132/87 GDSC1; GDSC2 -0.9234 6.5492 -2.4661 45.3906
SNU-5 GDSC1; GDSC2 -0.6399 6.5757 -2.1804 43.4731
NCI-N87 GDSC1; GDSC2 -0.503 9.1677 -3.1837 44.0726
SCH GDSC1 -0.2935 6.9645 -1.9864 47.4021
HSC-39 GDSC1 -0.2457 6.7331 -1.8372 46.9885
HGC-27 GDSC2 -0.2025 7.6982 -2.2158 41.3005
ECC10 GDSC1; GDSC2 -0.0526 5.3219 -1.0499 37.7687
NUGC-3 GDSC1; GDSC2 0.0506 7.2958 -1.7788 39.1812
SNU-16 GDSC1 0.5515 6.2041 -0.7851 40.0994
Hs 746.T GDSC1; GDSC2 0.5888 6.4538 -0.8563 33.9213
MKN1 GDSC1; GDSC2 0.6906 5.3619 -0.282 31.1717
RERF-GC-1B GDSC1; GDSC2 0.6953 8.383 -1.6306 35.8674
MKN45 GDSC1; GDSC2 0.871 6.6277 -0.6467 31.8453
GCIY GDSC2 0.9063 6.4399 -0.5266 31.2088
MKN7 GDSC1 1.1433 8.6885 -1.3393 38.2602
IM95 GDSC1; GDSC2 1.5712 6.7614 -0.0101 26.0853
SK-GT-2 GDSC1; GDSC2 1.6453 6.7312 0.0767 25.366
AGS GDSC1; GDSC2 1.751 7.0627 0.0224 25.2147
OCUM-1 GDSC1; GDSC2 1.7712 8.8404 -0.8164 28.8091
KATO III GDSC1; GDSC2 2.1792 8.9103 -0.4737 25.8949
NUGC-4 GDSC1; GDSC2 2.913 10.486 -0.6064 23.99
RF-48 GDSC1; GDSC2 2.9441 9.352 -0.0135 21.1696
SNU-1 GDSC1; GDSC2 3.0333 7.6502 0.9128 15.904
TGBC11TKB GDSC1; GDSC2 3.2846 8.8146 0.5444 17.2102
MKN28 GDSC1; GDSC2 3.5062 6.1378 2.0645 7.4392
ECC12 GDSC2 4.1056 11.5676 -0.1674 18.5075
SNG-M GDSC1; GDSC2 3.004 7.8953 0.7652 16.8453
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC1; GDSC2 -1.6623 2.5111 -1.9195 50.0151
KMH-2 GDSC1 -0.2838 3.6067 -0.6944 46.0091
IHH-4 GDSC1; GDSC2 0.515 5.5885 -0.5602 33.1638
8305C GDSC1; GDSC2 0.8364 8.6875 -1.636 35.2836
B-CPAP GDSC1; GDSC2 1.1791 8.8106 -1.3632 33.0581
BHT-101 GDSC1; GDSC2 1.7001 6.1767 0.39 23.5497
CAL-62 GDSC1; GDSC2 1.769 7.829 -0.328 26.7784
TT GDSC1 2.4034 25.6647 -8.6238 42.8571
ASH-3 GDSC1; GDSC2 2.4989 8.4063 0.065 22.2604
FTC-133 GDSC1; GDSC2 2.5153 8.6891 -0.0603 22.8181
8505C GDSC1; GDSC2 3.0163 7.8548 0.796 16.6305
HTC-C3 GDSC1; GDSC2 3.2138 5.7962 1.9936 8.7271
WRO GDSC1; GDSC2 3.3309 12.3595 -1.1893 25.0485
TT2609-C02 GDSC1; GDSC2 4.3763 10.8395 0.4016 14.9534
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KON GDSC1 -3.8453 0.0948 -3.91 79.0672
JHU-029 GDSC1 -2.4635 5.2736 -3.615 61.2903
PE/CA-PJ15 GDSC1 -1.7777 1.6562 -1.893 61.6417
BB49-HNC GDSC1; GDSC2 -1.3853 5.4108 -2.5058 48.1577
HO-1-u-1 GDSC1 -1.3142 4.5247 -2.1106 55.0485
JHU-011 GDSC1 -1.2695 5.2435 -2.3192 54.3381
BHY GDSC1 -0.8828 3.9201 -1.4431 51.851
OSC-19 GDSC1 -0.7707 8.1617 -3.0009 50.5277
DOK GDSC1; GDSC2 -0.618 6.4244 -2.0943 43.2219
BB30-HNC GDSC1 -0.3507 5.6571 -1.4992 47.4487
KOSC-2 GDSC1 -0.2317 4.9346 -1.091 46.148
PCI-38 GDSC1 -0.1488 5.0214 -1.0354 45.4386
BICR 22 GDSC1; GDSC2 -0.0227 7.4287 -1.9127 39.8336
BICR 10 GDSC1; GDSC2 0.0998 5.537 -0.975 36.7312
Detroit 562 GDSC1; GDSC2 0.1609 5.217 -0.7818 35.7623
HSC-2 GDSC1; GDSC2 0.2705 5.5445 -0.7983 35.2613
JHU-022 GDSC1; GDSC2 0.3193 7.6913 -1.6849 37.6858
HSC-3 GDSC1; GDSC2 0.3311 5.6053 -0.7597 34.8197
PCI-30 GDSC1 0.7731 8.7178 -1.712 40.9687
SAT [Human HNSCC] GDSC1; GDSC2 0.8287 8.0506 -1.3438 34.4569
SCC-25 GDSC1 0.8615 7.6586 -1.1287 39.1943
SAS GDSC1; GDSC2 0.9601 8.4886 -1.4214 34.1381
PCI-04B GDSC1; GDSC2 1.0464 5.937 -0.1601 29.0045
PCI-15A GDSC1 1.167 5.9788 -0.0555 33.7952
HO-1-N-1 GDSC1; GDSC2 1.4877 6.3475 0.1 25.8892
SCC-4 GDSC1; GDSC2 2.0118 7.2921 0.1616 23.5259
SKN-3 GDSC1; GDSC2 2.1304 9.41 -0.7644 27.285
SCC-9 GDSC1; GDSC2 2.4928 9.6214 -0.5429 25.1002
CAL-33 GDSC1; GDSC2 2.8189 8.9536 0.0767 21.128
FaDu GDSC1; GDSC2 3.0413 6.8317 1.328 13.4017
NCI-H3118 GDSC1; GDSC2 3.135 6.7271 1.4612 12.2949
SCC-15 GDSC1; GDSC2 3.2235 7.3824 1.209 13.5635
CAL-27 GDSC1; GDSC2 3.2889 5.4938 2.2084 7.1466
UPCI-SCC-090 GDSC1; GDSC2 3.3038 9.6244 0.1556 19.2047
LB771-HNC GDSC1; GDSC2 3.3809 11.1325 -0.5344 22.2374
HSC-4 GDSC1; GDSC2 3.4712 4.8465 2.6801 3.6498
Ca9-22 GDSC1; GDSC2 3.7196 6.9105 1.8473 8.2309
OSC-20 GDSC1; GDSC2 3.8325 10.0811 0.3579 16.6257
PCI-06A GDSC1 4.1207 9.8488 0.6979 16.8799
BICR 78 GDSC1; GDSC2 4.3661 13.4943 -0.9225 21.1407
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 GDSC1 -1.1537 2.4474 -1.3545 54.9823
T24 GDSC1 0.0484 2.9882 -0.1653 41.8264
RT-112 GDSC1; GDSC2 0.6277 7.238 -1.1685 34.7954
CAL-29 GDSC1; GDSC2 0.8646 7.1723 -0.901 32.8261
SW1710 GDSC1; GDSC2 1.1029 6.2773 -0.2543 29.181
RT-4 GDSC1; GDSC2 1.3043 7.3961 -0.5699 29.6717
KU-19-19 GDSC1; GDSC2 1.6762 6.2487 0.3329 23.9445
639V GDSC1; GDSC2 1.9024 6.0738 0.6376 21.419
5637 GDSC1; GDSC2 1.9664 7.2463 0.1407 23.802
HT-1197 GDSC1; GDSC2 2.0844 7.0496 0.3476 22.2959
647V GDSC1; GDSC2 2.1506 10.055 -1.0645 28.3728
BFTC-905 GDSC1; GDSC2 2.6722 8.7942 0.0271 21.8597
TCCSUP GDSC1; GDSC2 2.7927 8.7393 0.1605 20.7914
SW780 GDSC1; GDSC2 2.8679 7.4646 0.861 16.7318
HT-1376 GDSC1; GDSC2 4.8505 15.9161 -1.751 23.0293
J82 GDSC1; GDSC2 5.2043 14.4724 -0.7729 18.4627
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVCA420 GDSC1 -2.8273 6.9526 -4.6392 61.1419
KGN GDSC1 -2.7986 3.6308 -3.4444 65.3041
NT2-D1 GDSC1 -2.7803 3.2783 -3.3257 65.8233
SW962 GDSC1 -2.2691 3.8934 -2.9449 61.9823
PA-1 GDSC2 -1.7817 3.2006 -2.2152 50.9727
OVCA433 GDSC1 -1.6076 3.5884 -2.1329 57.9497
ACC-OV7 GDSC1 -1.36 9.5689 -4.2287 53.2494
CAL-39 GDSC1; GDSC2 -1.2611 4.0003 -1.8801 46.8835
SW954 GDSC1 -0.5617 3.6111 -0.9987 48.8607
C-33 A GDSC1; GDSC2 -0.2957 5.7069 -1.4611 40.2083
ME-180 GDSC1; GDSC2 -0.2603 8.9072 -2.8214 42.5323
UWB1.289 GDSC1 -0.1249 6.2611 -1.5107 45.8818
OMC-1 [Human cervical carcinoma] GDSC1 -0.0541 6.4098 -1.5001 45.3981
BPH-1 GDSC1; GDSC2 0.0086 6.4155 -1.4375 38.5495
NEC8 GDSC1; GDSC2 0.0315 5.1111 -0.8777 36.7693
JHOS-3 GDSC1 0.0495 9.5006 -2.789 46.0593
SKN GDSC1; GDSC2 0.3231 5.7485 -0.8278 35.1022
OVMIU GDSC1; GDSC2 0.7596 8.1369 -1.4522 35.0822
TC-YIK GDSC1; GDSC2 0.8648 7.7591 -1.1721 33.7551
JEG-3 GDSC1 0.9045 6.4941 -0.5527 37.2532
OV17R GDSC1 1.33 9.3729 -1.4901 37.7361
HEY GDSC1; GDSC2 1.3313 7.9834 -0.8216 30.5532
DSH1 GDSC1; GDSC2 1.5114 4.9568 0.7449 22.3935
LB831-BLC GDSC1; GDSC2 2.1984 8.1066 -0.061 23.9372
PWR-1E GDSC1; GDSC2 2.2588 7.3501 0.3653 21.5646
SKG-IIIa GDSC1; GDSC2 2.2731 8.2094 -0.0428 23.5807
Ca Ski GDSC1; GDSC2 2.3655 7.8395 0.2238 21.9222
SiSo GDSC1; GDSC2 2.6226 5.4571 1.6273 12.9425
SiHa GDSC1; GDSC2 2.8052 8.6637 0.2091 20.502
MS751 GDSC1; GDSC2 3.0206 7.8457 0.8042 16.5704
JAR GDSC1 3.0233 9.3204 0.0704 24.387
DoTc2 4510 GDSC1; GDSC2 3.082 8.2728 0.6438 17.2835
PEO1 GDSC1; GDSC2 3.0947 10.0623 -0.2394 21.7752
HEC-1 GDSC1; GDSC2 3.3123 8.1225 0.9136 15.045
HeLa GDSC1; GDSC2 3.5255 5.2835 2.5052 4.609
C-4-I GDSC1; GDSC2 3.5577 8.6196 0.867 14.5971
HT-3 GDSC1; GDSC2 3.7011 9.026 0.7794 14.6908
SW756 GDSC1; GDSC2 3.935 9.1831 0.8853 13.4506
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug

References

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2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014. Biochem Biophys Res Commun. 2014 Jan 10;443(2):406-12.
4 First-in-human pharmacokinetic and pharmacodynamic study of the dual m-TORC 1/2 inhibitor AZD2014. Clin Cancer Res. 2015 Aug 1;21(15):3412-9.
5 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.