Details of the Drug

General Information of Drug (ID: DMOFG4M)

Drug Name
2,3,4,5-Tetrahydro-benzo[f][1,4]oxazepine
Synonyms
17775-01-8; 2,3,4,5-Tetrahydrobenzo[f][1,4]oxazepine; 2,3,4,5-tetrahydro-1,4-benzoxazepine; 2,3,4,5-Tetrahydro-benzo[f][1,4]oxazepine; CHEMBL118420; 1,4-Benzoxazepine, 2,3,4,5-tetrahydro-; 2.3.4.5-tetrahydro-benzo[f][1,4]oxazepine; 1,4-Benzoxazepine, 2,3,4,5-tetrahydro-, hydrochloride; AC1Q1IB5; AC1Q1IB6; SCHEMBL400964; CTK4D6590; DTXSID90619367; HDVHFHONOKCUHQ-UHFFFAOYSA-N; MolPort-001-792-633; KS-00000I8M; ALBB-011885; CT-115; BDBM50052890; ZINC11802711; ANW-65610; STK897763; AKOS005173482; MCULE-4987146186; CS-W007152; BS-12101
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 149.19
Logarithm of the Partition Coefficient (xlogp) 1
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C9H11NO
IUPAC Name
2,3,4,5-tetrahydro-1,4-benzoxazepine
Canonical SMILES
C1COC2=CC=CC=C2CN1
InChI
InChI=1S/C9H11NO/c1-2-4-9-8(3-1)7-10-5-6-11-9/h1-4,10H,5-7H2
InChIKey
HDVHFHONOKCUHQ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
21882775
CAS Number
17775-01-8
TTD ID
D0M8FL

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor alpha-2A (ADRA2A) TTWG9A4 ADA2A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2B (ADRA2B) TTWM4TY ADA2B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 1.76E-01 -0.06 -0.28
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46.