Details of the Drug

General Information of Drug (ID: DMOFSLE)

Drug Name
IMD-0354
Synonyms
IMD-2560; IMD-2560); I-kappaB kinase beta inhibitor (dermatological, atopic dermatitis/acne), Institute of Medicinal MolecularDesign; I-kappaB kinase beta inhibitor (oral, rheumatoid arthritis/osteoporosis), IMMD; IKK-beta inhibitor (dermatological, atopic dermatitis/acne), IMMD; IL-6 release inhibitor (oral, rheumatoid arthritis/osteoporosis), IMMD
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 383.67
Logarithm of the Partition Coefficient (xlogp) 6.2
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C15H8ClF6NO2
IUPAC Name
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
Canonical SMILES
C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O
InChI
InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
InChIKey
CHILCFMQWMQVAL-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
5081913
ChEBI ID
CHEBI:93310
CAS Number
978-62-1
TTD ID
D0Z5DM
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Inhibitor of nuclear factor kappa-B kinase beta (IKKB) TTJ3E9X IKKB_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Acne vulgaris
ICD Disease Classification ED80
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DTT IKBKB 5.74E-08 0.26 0.88
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 1.0125 4.5174 0.655 42.7006
NOS-1 [Human HNSCC] GDSC1 -1.8459 -0.2852 -1.8462 76.4508
EW-13 GDSC1 -1.233 0.9576 -1.2405 68.4546
HuO9 GDSC1 -1.2303 2.3713 -1.3375 65.9321
EW-22 GDSC1 -1.1056 1.2506 -1.1191 66.7636
ES5 GDSC1 -1.0986 1.7302 -1.1362 65.9576
H-EMC-SS GDSC1 -0.6929 1.647 -0.7119 62.0212
NY GDSC1 -0.6408 3.2114 -0.8362 59.7207
SK-ES-1 GDSC1 -0.6299 1.1958 -0.6341 61.6625
U2OS GDSC1 -0.4457 2.5349 -0.5241 58.5954
CHSA8926 GDSC1 -0.4326 3.3584 -0.6391 57.7006
HOS GDSC1 -0.3639 1.524 -0.3712 58.3941
MG-63 GDSC1 -0.3429 1.4135 -0.3476 58.1871
HuO-3N1 GDSC1 -0.3249 4.3357 -0.753 55.9339
EW-18 GDSC1 -0.205 0.9601 -0.2052 56.5784
ES7 GDSC1 -0.0562 1.3544 -0.0576 54.7066
CADO-ES1 GDSC1 0.1085 1.733 0.1036 52.6439
MHH-ES-1 GDSC1 0.1346 1.5697 0.1325 52.3307
A-673 GDSC1 0.1652 1.5139 0.1638 51.9537
CAL-78 GDSC1 0.1742 3.7608 -0.0647 51.5531
SK-PN-DW GDSC1 0.3642 1.4244 0.3639 49.4724
SaOS-2 GDSC1 0.6349 3.9223 0.3998 46.5957
SJSA-1 GDSC1 0.6885 3.7198 0.5034 45.9004
EW-16 GDSC1 0.7801 3.1626 0.7004 44.5596
CAL-72 GDSC1 0.8376 3.3561 0.7328 43.9481
EW-7 GDSC1 0.8817 1.9299 0.881 43.0065
ES1 GDSC1 0.9807 2.8128 0.9509 41.914
EW-1 GDSC1 1.0574 2.7535 1.0352 40.9257
G-292 clone A141B1 GDSC1 1.1413 9.4533 -1.2119 45.054
ES8 GDSC1 1.2746 2.6819 1.2637 38.1567
EW-3 GDSC1 1.3514 3.7397 1.2185 37.8552
TC-71 GDSC1 1.724 2.4213 1.7239 32.4746
ES6 GDSC1 1.9367 6.1519 1.0631 34.6405
ES4 GDSC1 2.1812 3.4673 2.1518 26.9451
EW-24 GDSC1 5.8291 14.3152 0.519 21.0047
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 152 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -0.1626 1.291 -0.1641 56.0258
QIMR-WIL GDSC1 -1.9583 0.0153 -1.96 76.9695
A4/Fukuda GDSC1 -1.9411 -1.1282 -1.9411 78.2453
OCI-AML-2 GDSC1 -1.9172 -1.1809 -1.9172 77.9677
NU-DUL-1 GDSC1 -1.7336 -0.306 -1.7338 75.2978
MV4-11 GDSC1 -1.7114 -0.578 -1.7114 75.2756
Loucy GDSC1 -1.6955 -0.4948 -1.6955 75.0392
Ku812 GDSC1 -1.5999 -0.2228 -1.6 73.744
KMOE-2 GDSC1 -1.5956 0.5271 -1.5998 72.6714
SU-DHL-16 GDSC1 -1.4871 -0.3926 -1.4871 72.5369
YT GDSC1 -1.4679 0.2263 -1.4687 71.8443
SUP-B15 GDSC1 -1.4483 0.2907 -1.4494 71.5606
ML-2 GDSC1 -1.375 0.4655 -1.3769 70.5746
LP-1 GDSC1 -1.3667 0.5968 -1.3697 70.3159
DEL GDSC1 -1.3663 -0.0369 -1.3664 70.9395
TUR GDSC1 -1.3567 0.3842 -1.3579 70.4749
MLMA GDSC1 -1.3436 -0.6711 -1.3436 70.8168
U-698-M GDSC1 -1.321 1.8243 -1.3755 67.7275
BC-3 GDSC1 -1.2943 0.4891 -1.2959 69.6884
SIG-M5 GDSC1 -1.269 -0.6591 -1.269 69.8857
ALL-PO GDSC1 -1.2507 0.2838 -1.2512 69.3947
RPMI-8402 GDSC1 -1.2119 -0.1248 -1.212 69.1313
PF-382 GDSC1 -1.2044 0.5551 -1.206 68.6434
Ramos.2G6.4C10 GDSC1 -1.1835 -0.398 -1.1835 68.8131
SUP-HD1 GDSC1 -1.1686 0.8881 -1.1739 67.89
EJM GDSC1 -1.1538 0.6029 -1.1555 68.0411
RPMI-8866 GDSC1 -1.1465 0.8716 -1.1513 67.6783
L-363 GDSC1 -1.0784 0.5408 -1.0793 67.243
Karpas-45 GDSC1 -1.0667 0.617 -1.0681 67.0543
DoHH2 GDSC1 -1.064 -0.149 -1.064 67.3139
HL-60 GDSC1 -1.042 -0.0501 -1.042 67.0321
DND-41 GDSC1 -1.0225 0.6412 -1.0238 66.5337
K-562 GDSC1 -1.0069 2.939 -1.1828 63.163
SU-DHL-6 GDSC1 -1.0068 0.6843 -1.0083 66.3238
MHH-PREB-1 GDSC1 -1.0062 0.2708 -1.0064 66.53
BL-41 GDSC1 -1.0056 0.7363 -1.0075 66.2716
LAMA-84 GDSC1 -0.9824 0.3487 -0.9825 66.2168
BV-173 GDSC1 -0.9394 0.8275 -0.9417 65.4524
HDLM-2 GDSC1 -0.924 0.8352 -0.9263 65.2724
ALL-SIL GDSC1 -0.9173 1.0839 -0.9231 64.9904
CTV-1 GDSC1 -0.9145 1.2557 -0.9243 64.7863
SUP-T1 GDSC1 -0.9104 1.0304 -0.9151 64.9627
P12-Ichikawa GDSC1 -0.8897 1.0949 -0.8953 64.6767
BC-1 GDSC1 -0.8694 0.1757 -0.8695 64.876
ST486 GDSC1 -0.8463 0.8015 -0.8478 64.3998
ROS-50 GDSC1 -0.8324 0.0667 -0.8324 64.4248
IM-9 GDSC1 -0.8154 1.6593 -0.8387 63.2964
CTB-1 GDSC1 -0.7667 1.9825 -0.8088 62.4167
P32/ISH GDSC1 -0.7639 0.5663 -0.7642 63.5138
L-540 GDSC1 -0.7579 0.7013 -0.7585 63.3998
Sc-1 GDSC1 -0.7464 0.5327 -0.7466 63.3086
NOMO-1 GDSC1 -0.7372 0.7796 -0.7381 63.1234
DB GDSC1 -0.7309 0.6511 -0.7314 63.0912
NK-92MI GDSC1 -0.7172 1.2547 -0.7238 62.6237
HC-1 GDSC1 -0.7057 1.664 -0.7259 62.1418
CA46 GDSC1 -0.7044 1.0545 -0.7074 62.607
Karpas-620 GDSC1 -0.6949 0.7588 -0.6956 62.6239
MC116 GDSC1 -0.6871 0.3067 -0.6871 62.6053
Daudi GDSC1 -0.6863 1.76 -0.7108 61.8401
SU-DHL-1 GDSC1 -0.6847 1.139 -0.6887 62.3301
OCI-AML-5 GDSC1 -0.6529 0.1627 -0.6529 62.1836
SUP-M2 GDSC1 -0.6502 1.4483 -0.6606 61.7257
KE-37 GDSC1 -0.6284 0.1521 -0.6284 61.8785
P30/OHK GDSC1 -0.5899 0.5479 -0.59 61.3823
MY-M12 GDSC1 -0.5822 1.1226 -0.585 61.1411
GA-10 GDSC1 -0.5804 0.3258 -0.5804 61.2767
SU-DHL-4 GDSC1 -0.5688 0.6648 -0.5689 61.1073
OCI-M1 GDSC1 -0.5594 0.8697 -0.5601 60.954
MOLT-16 GDSC1 -0.5587 0.2818 -0.5587 61.0061
Karpas-231 GDSC1 -0.5496 1.1947 -0.553 60.7247
SU-DHL-10 GDSC1 -0.5355 0.6064 -0.5356 60.7027
HEL GDSC1 -0.5346 0.3304 -0.5346 60.7048
HT GDSC1 -0.5325 0.466 -0.5326 60.6753
KG-1 GDSC1 -0.5109 0.968 -0.512 60.3415
NALM-6 GDSC1 -0.5041 0.4493 -0.5041 60.3215
MOLT-13 GDSC1 -0.5014 0.8975 -0.502 60.2416
RPMI-8226 GDSC1 -0.4979 0.6106 -0.498 60.2366
Jiyoye GDSC1 -0.4375 0.8074 -0.4377 59.4708
HAL-01 GDSC1 -0.4369 0.8281 -0.4372 59.4614
SU-DHL-5 GDSC1 -0.4308 0.3245 -0.4308 59.4088
RCH-ACV GDSC1 -0.4296 0.959 -0.4303 59.3526
H9 GDSC1 -0.4151 0.9408 -0.4157 59.1777
A3/Kawakami GDSC1 -0.4073 0.6248 -0.4074 59.1105
KOPN-8 GDSC1 -0.3986 0.5355 -0.3986 59.0042
GDM-1 GDSC1 -0.386 0.5502 -0.386 58.8471
MOLM-13 GDSC1 -0.3546 1.0024 -0.3552 58.4248
OCI-Ly19 GDSC1 -0.3481 1.0708 -0.3491 58.3352
KCL-22 GDSC1 -0.339 2.0914 -0.3712 57.805
MOLP-8 GDSC1 -0.3216 0.5019 -0.3216 58.044
L-428 GDSC1 -0.3142 0.9282 -0.3145 57.9348
RS4;11 GDSC1 -0.2996 0.8183 -0.2997 57.7616
Jurkat GDSC1 -0.2942 0.7699 -0.2943 57.6965
EoL-1 GDSC1 -0.2573 0.8078 -0.2574 57.2361
SR GDSC1 -0.237 0.9765 -0.2373 56.9747
VAL GDSC1 -0.2193 1.46 -0.2233 56.6879
KMS-12-BM GDSC1 -0.2192 0.4344 -0.2192 56.7635
Mono-Mac-6 GDSC1 -0.2058 1.3091 -0.2078 56.5532
OCI-AML-3 GDSC1 -0.2047 2.7566 -0.2953 55.9249
JJN-3 GDSC1 -0.1946 0.9448 -0.1947 56.4493
KM-H2 GDSC1 -0.1793 2.8586 -0.282 55.5955
Karpas-422 GDSC1 -0.1752 0.9137 -0.1753 56.209
NB4 GDSC1 -0.1615 0.2961 -0.1615 56.043
697 GDSC1 -0.1456 0.8831 -0.1456 55.8409
Farage GDSC1 -0.1189 1.8694 -0.1321 55.3738
L-1236 GDSC1 -0.1011 5.7605 -0.9624 53.3538
CESS GDSC1 -0.1008 1.0841 -0.1011 55.2777
BE-13 GDSC1 -0.0985 1.3735 -0.1003 55.2271
CCRF-CEM GDSC1 -0.0946 1.3757 -0.0964 55.1787
THP-1 GDSC1 -0.0772 1.1757 -0.0777 54.979
NKM-1 GDSC1 -0.0498 1.1887 -0.0503 54.638
RPMI-6666 GDSC1 -0.0308 1.7353 -0.038 54.3473
WIL2 NS GDSC1 0.0151 1.3374 0.0142 53.8245
MEG-01 GDSC1 0.021 1.7259 0.0149 53.7175
JSC-1 GDSC1 0.0752 1.1497 0.075 53.0822
VL51 GDSC1 0.1353 1.97 0.1242 52.2947
EB2 GDSC1 0.1599 2.5356 0.1148 51.9268
ME1 GDSC1 0.1648 0.752 0.1648 51.9638
MN-60 GDSC1 0.1652 3.3475 0.0097 51.7254
BALL-1 GDSC1 0.1657 7.6529 -1.4159 51.0302
EM-2 GDSC1 0.1842 1.2878 0.184 51.7201
SU-DHL-8 GDSC1 0.1876 0.8642 0.1876 51.6791
Reh GDSC1 0.2001 1.2376 0.1999 51.5227
PL-21 GDSC1 0.2714 1.6063 0.2698 50.6304
HH [Human lymphoma] GDSC1 0.2826 4.7669 -0.2154 50.3702
JURL-MK1 GDSC1 0.3005 2.0563 0.2902 50.2638
OPM-2 GDSC1 0.3038 1.6672 0.3019 50.2263
TK [Human B-cell lymphoma] GDSC1 0.3185 2.2661 0.2993 50.0423
Karpas-299 GDSC1 0.3245 1.5513 0.3236 49.9682
EHEB GDSC1 0.3318 4.2534 -0.0141 49.9003
LC4-1 GDSC1 0.3483 3.4925 0.1804 49.7082
GR-ST GDSC1 0.4219 5.8158 -0.4188 49.1604
Raji GDSC1 0.4281 2.2398 0.4136 48.6936
KY821 GDSC1 0.4533 3.0029 0.3733 48.4598
KMS-11 GDSC1 0.5015 1.8003 0.4997 47.7604
AMO1 GDSC1 0.511 3.2384 0.4008 47.818
MOLT-4 GDSC1 0.5757 2.5283 0.5499 46.8981
DG-75 GDSC1 0.6221 6.1665 -0.3356 47.5259
Granta-519 GDSC1 0.6452 4.04 0.3827 46.5272
U266B1 GDSC1 0.6713 2.9791 0.6083 45.8252
Hs 445 GDSC1 0.7243 2.0081 0.7218 44.9821
SK-MM-2 GDSC1 0.9638 2.9456 0.9212 42.1804
SKM-1 GDSC1 1.2667 4.6672 0.8873 39.9297
ATN-1 GDSC1 1.2933 2.4049 1.2907 37.874
SCC-3 GDSC1 1.322 2.9118 1.2994 37.6325
RC-K8 GDSC1 1.5155 9.1784 -0.7128 42.3277
WSU-DLCL2 GDSC1 1.5931 4.5028 1.2926 35.7884
ARH-77 GDSC1 2.4765 6.9402 1.2752 30.4713
JVM-2 GDSC1 2.8942 4.9226 2.5666 20.0653
WSU-NHL GDSC1 3.1566 8.4291 1.2315 27.2601
P31/FUJ GDSC1 3.1603 10.8994 0.0212 32.4704
RL GDSC1 5.9014 11.7835 1.8114 13.8371
JVM-3 GDSC1 6.026 14.7245 0.4634 20.6967
⏷ Show the Full List of 152 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACP4 C GDSC1 -1.6759 2.2443 -1.7955 69.4477
KYSE-50 GDSC1 -1.424 4.2434 -1.9275 63.8792
FLO-1 GDSC1 -0.655 2.0497 -0.6974 61.2123
KYAE-1 GDSC1 -0.078 2.8569 -0.1737 54.5168
HCE-4 GDSC1 0.2783 3.2101 0.1552 50.4939
TE-12 GDSC1 0.3308 4.9414 -0.2173 49.9174
OACM5.1 C GDSC1 1.0537 9.0962 -1.1361 45.4577
ESO-26 GDSC1 1.1634 4.453 0.8383 40.9004
KYSE-220 GDSC1 1.1773 7.8714 -0.4615 43.8678
SK-GT-4 GDSC1 2.3357 8.5744 0.3766 35.1128
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 0.0451 2.7301 -0.0266 53.206
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-5 GDSC1 -3.1318 -2.1172 -3.1318 91.6291
SJNB-6 GDSC1 -2.7448 -1.446 -2.7448 86.9485
CHP-212 GDSC1 -2.5347 -0.9696 -2.5348 84.0787
SK-N-BE(2)-M17 GDSC1 -2.4785 -0.9311 -2.4786 83.5333
GI-ME-N GDSC1 -2.4562 -0.3167 -2.458 81.6846
SK-N-DZ GDSC1 -2.3829 -1.42 -2.3829 83.5324
SJNB-10 GDSC1 -2.3211 -1.5846 -2.3211 82.9653
NB69 GDSC1 -2.252 -1.1494 -2.252 81.8189
SJNB-13 GDSC1 -2.1018 -1.1619 -2.1018 80.1636
SJNB-14 GDSC1 -2.0925 -0.3839 -2.0929 78.9938
SK-N-FI GDSC1 -2.0513 -0.6143 -2.0514 79.013
SK-N-MC-IXC GDSC1 -1.9177 -1.3557 -1.9177 77.9922
SJNB-7 GDSC1 -1.7933 0.0284 -1.7943 75.4313
Kelly GDSC1 -1.7471 -0.5507 -1.7471 75.669
IMR-5 GDSC1 -1.7345 -0.7322 -1.7345 75.6253
NH-12 GDSC1 -1.6624 -0.0961 -1.6627 74.2941
KP-N-YS GDSC1 -1.4655 -0.2311 -1.4655 72.207
NB1 GDSC1 -1.408 -0.2218 -1.408 71.5242
SJNB-12 GDSC1 -1.2598 -0.0132 -1.2599 69.6732
MHH-NB-11 GDSC1 -1.1987 1.716 -1.2394 66.8851
GOTO GDSC1 -1.1473 1.035 -1.1553 67.4807
SiMa GDSC1 -1.1385 0.7087 -1.141 67.7709
SJNB-17 GDSC1 -1.0628 0.6557 -1.0644 66.9803
NB(TU)1 GDSC1 -0.9841 1.6156 -1.0105 65.0466
SK-N-AS GDSC1 -0.9778 1.3697 -0.9927 65.3142
CHP-134 GDSC1 -0.6915 0.3767 -0.6915 62.655
SK-N-SH GDSC1 -0.6693 1.5623 -0.6841 61.8429
KP-N-YN GDSC1 0.0012 1.4776 -0.0009 53.9873
LA-N-6 GDSC1 0.2486 3.3025 0.1077 50.8189
TGW GDSC1 1.8355 2.5707 1.8351 31.0826
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -0.5145 1.2611 -0.5186 60.2817
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1599 GDSC1 -2.603 -1.559 -2.603 85.9736
HCC2157 GDSC1 -2.5835 1.5009 -2.672 76.6195
MRK-nu-1 GDSC1 -2.4451 -1.1562 -2.4451 83.7425
Hs 578T GDSC1 -2.0797 1.2005 -2.1201 74.7743
UACC-893 GDSC1 -2.0587 0.1377 -2.0621 77.5225
MFM-223 GDSC1 -2.0301 -0.4094 -2.0303 78.4639
OCUB-M GDSC1 -1.9557 -0.3877 -1.956 77.7075
MDA-MB-453 GDSC1 -1.934 2.2819 -2.0759 70.982
HCC202 GDSC1 -1.4518 2.0653 -1.5364 68.2608
BT-474 GDSC1 -1.3664 0.4063 -1.3678 70.5541
HCC2218 GDSC1 -1.3588 0.9087 -1.3672 69.7657
AU565 GDSC1 -1.095 2.017 -1.1555 65.4443
MDA-MB-231 GDSC1 -1.0189 3.5988 -1.3263 62.2228
DU4475 GDSC1 -0.9563 1.2832 -0.9678 65.197
HCC1419 GDSC1 -0.9428 1.445 -0.9598 64.8618
HCC1187 GDSC1 -0.7732 1.4119 -0.785 63.1105
MDA-MB-468 GDSC1 -0.6888 2.5449 -0.7835 60.9681
HCC1500 GDSC1 -0.5476 2.8633 -0.6768 59.2688
MDA-MB-157 GDSC1 -0.5161 0.9045 -0.5168 60.4192
CAL-85-1 GDSC1 -0.4659 1.3534 -0.471 59.6679
HDQ-P1 GDSC1 -0.4318 5.7299 -1.3088 55.7509
HCC70 GDSC1 -0.4125 3.7758 -0.7066 57.1395
MDA-MB-361 GDSC1 -0.389 2.612 -0.4731 57.9491
COLO 824 GDSC1 -0.3877 1.8043 -0.4053 58.5283
HCC1569 GDSC1 -0.0914 5.5447 -0.8763 53.3672
HCC38 GDSC1 -0.0068 2.3779 -0.0463 53.9052
CAL-148 GDSC1 0.0351 3.2721 -0.1173 53.138
CAL-51 GDSC1 0.306 2.1682 0.2913 50.1955
CAMA-1 GDSC1 0.4224 8.4509 -1.4904 49.3739
CAL-120 GDSC1 0.4471 4.9251 -0.0857 48.821
Evsa-T GDSC1 0.4672 7.5791 -1.07 49.002
MCF-7 GDSC1 0.5108 3.3844 0.3761 47.8516
MDA-MB-436 GDSC1 0.5743 8.4321 -1.3261 48.3996
BT-549 GDSC1 0.5821 2.8378 0.5298 46.8782
HCC1428 GDSC1 0.6201 8.5655 -1.3379 48.1266
HCC1395 GDSC1 0.891 11.0244 -2.1901 47.0983
EFM-19 GDSC1 1.0073 13.2375 -3.1293 47.0511
MDA-MB-175-VII GDSC1 1.0701 4.239 0.7954 41.7889
HCC1806 GDSC1 1.1164 5.3811 0.4863 42.3554
MDA-MB-330 GDSC1 1.3084 10.424 -1.4988 44.4975
ZR-75-30 GDSC1 1.5577 9.9446 -1.0293 42.6231
UACC-812 GDSC1 1.5862 6.619 0.5013 39.0324
MDA-MB-415 GDSC1 1.767 6.8383 0.5957 37.5714
BT-20 GDSC1 2.5277 8.1051 0.7855 32.5098
T-47D GDSC1 2.7084 11.711 -0.7906 36.7912
YMB-1-E GDSC1 2.9511 11.5161 -0.4729 34.9203
BT-483 GDSC1 4.024 10.0898 1.1861 23.7746
HCC1937 GDSC1 4.5911 13.4636 -0.0266 27.2077
HCC1954 GDSC1 4.7048 11.5451 1.0242 22.105
EFM-192A GDSC1 7.0699 17.8774 -0.3246 21.2578
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GI-1 GDSC1 -1.7342 -0.239 -1.7344 75.2273
U-251MG GDSC1 -1.5775 0.4872 -1.5811 72.5717
LN-18 GDSC1 -1.2828 0.6344 -1.2857 69.398
PFSK-1 GDSC1 -1.1705 0.546 -1.1719 68.2776
D283 Med GDSC1 -1.1036 0.4432 -1.1042 67.5983
GaMG GDSC1 -1.0817 1.7552 -1.1204 65.7614
SF126 GDSC1 -1.0371 0.6272 -1.0384 66.7102
GB-1 GDSC1 -0.9969 0.8166 -0.9995 66.1088
DK-MG GDSC1 -0.8399 2.1861 -0.9033 62.8599
A-172 GDSC1 -0.74 5.5835 -1.5919 57.9225
D-247MG GDSC1 -0.627 1.8851 -0.6567 61.0902
YKG-1 GDSC1 -0.5946 2.3653 -0.6629 60.2629
YH-13 GDSC1 -0.5888 1.7405 -0.6092 60.8124
MOG-G-CCM GDSC1 -0.3982 3.1192 -0.5578 57.5984
D-566MG GDSC1 -0.1136 1.3903 -0.1157 55.4104
D-542MG GDSC1 -0.0869 3.8174 -0.3618 54.1307
AM-38 GDSC1 -0.0318 2.5135 -0.0847 54.1469
SW1783 GDSC1 0.0203 1.864 0.0104 53.7055
CAS-1 GDSC1 0.0277 2.3805 -0.0105 53.5047
H4 GDSC1 0.0769 3.0189 -0.0311 52.7674
SF539 GDSC1 0.1414 3.4855 -0.0423 51.9522
D-336MG GDSC1 0.156 2.754 0.0882 51.9376
LNZTA3WT4 GDSC1 0.1705 3.4927 -0.0122 51.642
D-263MG GDSC1 0.2404 4.1245 -0.0801 50.8274
Daoy GDSC1 0.2731 2.6745 0.2206 50.5794
D-423MG GDSC1 0.286 3.2529 0.1565 50.4051
KINGS-1 GDSC1 0.3328 3.2578 0.206 49.8771
U-87MG ATCC GDSC1 0.388 4.9497 -0.1578 49.3843
Hs 683 GDSC1 0.4811 4.2674 0.1451 48.3659
NMC-G1 GDSC1 0.5471 3.114 0.4583 47.3638
SF295 GDSC1 0.6506 3.5653 0.4936 46.2787
LN-405 GDSC1 0.6603 3.6719 0.4827 46.2079
D-392MG GDSC1 0.881 3.2624 0.7939 43.3665
KS-1 [Human Krukenberg tumour] GDSC1 0.8997 2.3944 0.8909 42.8226
MOG-G-UVW GDSC1 1.0789 5.5506 0.3848 42.8984
8-MG-BA GDSC1 1.0913 4.8981 0.6236 42.1641
DBTRG-05MG GDSC1 1.1472 6.3525 0.1496 42.9395
U-118MG GDSC1 1.2072 4.0281 0.9982 39.9402
SNB-75 GDSC1 1.3214 7.4193 -0.1158 42.3392
M059J GDSC1 1.3902 4.7137 1.0075 38.5381
ONS-76 GDSC1 1.4029 4.1004 1.1939 37.6067
Onda 11 GDSC1 1.4217 3.8401 1.2742 37.0726
Becker GDSC1 1.5901 6.186 0.6845 38.3894
LN-229 GDSC1 1.7113 7.6564 0.1785 39.2261
SF268 GDSC1 1.8545 5.9113 1.0746 35.103
D-502MG GDSC1 1.8698 7.6837 0.3267 37.8497
SW1088 GDSC1 2.458 6.4597 1.4716 29.5182
KNS-81-FD GDSC1 2.6772 16.5417 -3.2075 41.0629
T98G GDSC1 2.8153 6.9295 1.6189 26.7666
Onda 10 GDSC1 2.9696 7.399 1.5497 26.3952
42-MG-BA GDSC1 3.1908 5.6213 2.5913 18.3603
SK-MG-1 GDSC1 3.4079 7.6285 1.8564 22.4368
KALS-1 GDSC1 3.9949 10.6297 0.8915 25.3999
KNS-42 GDSC1 6.2447 7.5818 3.8873 0.3162
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -1.6938 0.1218 -1.695 74.3083
TGBC24TKB GDSC1 1.4723 5.3202 0.8918 38.421
TGBC1TKB GDSC1 1.7229 12.5507 -2.1182 43.2972
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1 -2.4796 2.7503 -2.7383 72.6141
RL95-2 GDSC1 -0.9078 0.2441 -0.9079 65.3391
MFE-296 GDSC1 -0.0843 4.1229 -0.4338 53.9531
MFE-280 GDSC1 0.6833 11.6532 -2.6891 48.2823
ESS-1 GDSC1 0.9028 2.6369 0.8823 42.8387
EN GDSC1 1.5665 5.616 0.8837 37.8024
KLE GDSC1 1.936 9.6162 -0.5054 39.7043
MFE-319 GDSC1 1.9432 20.427 -5.7898 45.2844
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB2241-RCC GDSC1 -0.8838 1.0161 -0.888 64.6792
KTCTL-195 GDSC1 -0.8708 1.6899 -0.8975 63.8227
KTCTL-140 GDSC1 -0.6886 1.4851 -0.701 62.1211
KTCTL-21 GDSC1 -0.5947 2.3844 -0.665 60.2433
SW13 GDSC1 -0.5153 2.326 -0.5753 59.5011
SN12C GDSC1 -0.4534 2.9672 -0.592 58.2673
KTCTL-13 GDSC1 -0.4074 3.8761 -0.7248 57.0075
NCC021 GDSC1 -0.2165 2.2618 -0.2562 56.3405
LB996-RCC GDSC1 -0.1678 1.8447 -0.1814 55.9616
BB65-RCC GDSC1 -0.1274 3.7069 -0.3807 54.5769
786-O GDSC1 -0.1102 2.846 -0.2065 54.868
BFTC-909 GDSC1 -0.0823 2.1291 -0.1073 54.8619
LB1047-RCC GDSC1 -0.077 4.4594 -0.517 53.7258
HA7-RCC GDSC1 0.0159 3.8203 -0.2504 53.1315
CAL-54 GDSC1 0.2119 2.5059 0.1719 51.3173
RCC10RGB GDSC1 0.2544 4.2618 -0.1009 50.675
769-P GDSC1 0.3779 2.7717 0.321 49.3352
KTCTL-26A GDSC1 0.5724 4.5478 0.1661 47.489
Caki-1 GDSC1 0.5898 4.3579 0.2391 47.2455
KTCTL-1M GDSC1 0.6732 3.5288 0.5251 45.9995
VMRC-RCZ GDSC1 0.7297 4.1434 0.4489 45.6309
VMRC-RCW GDSC1 1.194 4.0555 0.9772 40.1282
TK-10 GDSC1 1.2634 5.0796 0.7503 40.4481
KMRC-20 GDSC1 1.3237 5.6579 0.6079 40.4759
UO-31 GDSC1 1.3724 3.5691 1.2729 37.4265
ACHN GDSC1 1.6148 9.4355 -0.7344 41.8343
KMRC-1 GDSC1 1.7687 5.3228 1.21 35.0217
A-704 GDSC1 2.0203 4.4911 1.7619 30.3895
OS-RC-2 GDSC1 2.1163 8.6814 0.1117 37.1437
SW156 GDSC1 2.988 9.2765 0.6608 30.7732
RXF 393L GDSC1 4.1994 9.4084 1.6759 20.2671
A-498 GDSC1 5.9068 14.8138 0.3311 21.6271
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKO GDSC1 -0.9715 0.4682 -0.9719 66.0397
GP5d GDSC1 -0.2366 1.9075 -0.2547 56.7419
SNU-175 GDSC1 -0.2026 1.2657 -0.2042 56.5205
HCT 116 GDSC1 -0.1533 1.5493 -0.1581 55.8686
LoVo GDSC1 -0.0245 1.0176 -0.0246 54.3285
SNU-C2B GDSC1 0.2285 2.8978 0.1476 51.0846
SW1417 GDSC1 0.4608 6.2561 -0.5422 48.8893
SW837 GDSC1 0.523 3.8238 0.3006 47.8156
NCI-H747 GDSC1 0.9223 6.2191 -0.036 44.9085
CaR-1 GDSC1 1.0199 7.8597 -0.6179 45.0707
RCM-1 [Human ESC] GDSC1 1.0943 7.8296 -0.5284 44.4846
CL-11 GDSC1 1.1224 5.8529 0.3188 42.7334
COLO 320HSR GDSC1 1.1495 6.7359 -0.0043 43.2428
CCK-81 GDSC1 1.1784 3.8431 1.0092 40.1141
HT115 GDSC1 1.1921 3.4183 1.1038 39.5839
COLO205 GDSC1 1.2385 2.4982 1.2332 38.5743
CW-2 GDSC1 1.3991 3.8096 1.256 37.3259
LS513 GDSC1 1.4202 3.7363 1.2937 36.9823
HT-29 GDSC1 1.4819 3.4184 1.4143 35.8996
SNU-81 GDSC1 1.6111 5.0716 1.1295 36.4513
KM12 GDSC1 1.6175 4.9442 1.1798 36.1732
C2BBe1 GDSC1 1.7653 6.9618 0.5404 37.7732
HCT 15 GDSC1 1.8915 5.6848 1.2038 34.2637
SNU-407 GDSC1 1.961 8.3537 0.1114 37.9875
HT-55 GDSC1 2.0682 7.1946 0.7477 35.1934
SW948 GDSC1 2.2974 4.821 1.9585 27.502
SW1116 GDSC1 2.379 11.7359 -1.107 38.9136
SNU-C5 GDSC1 2.3994 8.7498 0.3554 34.8575
LS411N GDSC1 2.4305 8.8163 0.3538 34.7037
NCI-H716 GDSC1 2.4347 6.5543 1.406 30.0083
SW48 GDSC1 2.7406 8.7941 0.6619 31.9545
SNU-61 GDSC1 2.7406 10.9584 -0.3915 35.5978
LS180 GDSC1 3.1831 6.3574 2.2488 20.8467
SNU-C1 GDSC1 3.3026 8.7031 1.2331 26.5778
T84 GDSC1 3.4303 8.8014 1.3018 25.6335
SW1463 GDSC1 3.6369 9.9407 0.9231 26.6973
LS1034 GDSC1 4.2654 9.6449 1.6132 20.3978
HCC2998 GDSC1 4.961 11.9444 1.0293 21.2052
SW626 GDSC1 5.1613 15.2455 -0.457 26.9536
SNU-1040 GDSC1 5.837 16.5701 -0.5899 25.4476
SW620 GDSC1 5.8999 15.2356 0.1178 22.5613
MDST8 GDSC1 6.1726 14.8265 0.5208 20.0247
COLO 678 GDSC1 6.3681 13.7326 1.1935 16.1333
LS123 GDSC1 6.829 11.2995 2.6347 6.3636
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -0.4679 1.1887 -0.4705 59.7567
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-2 GDSC1 -2.3746 -0.4425 -2.3755 81.4627
Hep 3B2.1-7 GDSC1 -1.9975 -0.4323 -1.9977 78.1903
SNU-423 GDSC1 -1.8476 -0.6443 -1.8477 76.8818
SNU-398 GDSC1 -1.5125 1.9076 -1.5842 69.061
Huh-7 GDSC1 -1.1489 3.8053 -1.5158 62.8246
JHH-4 GDSC1 -1.134 0.3157 -1.1344 68.0288
SK-HEP-1 GDSC1 -0.8568 1.7779 -0.8883 63.5708
SNU-387 GDSC1 -0.7816 1.6821 -0.805 62.9203
JHH-1 GDSC1 -0.4815 2.4216 -0.5494 59.0653
HLE GDSC1 -0.0006 2.4247 -0.0437 53.8192
Hep-G2/C3A GDSC1 0.4209 3.5871 0.2404 48.9083
JHH-7 GDSC1 0.563 2.6718 0.5255 47.0795
SNU-449 GDSC1 1.0772 4.3941 0.7609 41.8478
SNU-475 GDSC1 1.5425 4.9701 1.0897 37.1028
JHH-6 GDSC1 3.4946 11.3426 0.1003 30.7931
HuH-1 GDSC1 4.325 7.2653 2.8528 11.5335
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H446 GDSC1 -1.4212 0.268 -1.4221 71.2977
NCI-H1581 GDSC1 -1.3773 1.7287 -1.4266 68.3825
NCI-H847 GDSC1 -1.3553 0.3848 -1.3565 70.4591
NCI-H1048 GDSC1 -1.2039 0.3338 -1.2044 68.8247
NCI-H510A GDSC1 -1.1895 1.6576 -1.2258 66.9066
UMC-11 GDSC1 -1.0957 0.4104 -1.0962 67.5272
ABC-1 GDSC1 -1.0515 3.2499 -1.2881 63.0089
NCI-H211 GDSC1 -0.971 1.5817 -0.9951 64.9649
NCI-H1648 GDSC1 -0.913 2.1738 -0.9791 63.5584
NCI-H2342 GDSC1 -0.8959 5.5966 -1.7653 58.8912
LK-2 GDSC1 -0.8553 1.9716 -0.9005 63.3003
NCI-H69 GDSC1 -0.8395 2.8041 -0.9808 61.9796
EPLC-272H GDSC1 -0.8249 1.8696 -0.8612 63.1364
LC-2/ad GDSC1 -0.8175 2.8313 -0.9615 61.7508
NCI-H1688 GDSC1 -0.7398 0.4082 -0.7398 63.2479
NCI-H1341 GDSC1 -0.7229 0.6347 -0.7232 62.998
A-427 GDSC1 -0.6788 0.8372 -0.6798 62.404
LCLC-97TM1 GDSC1 -0.6777 0.4458 -0.6778 62.4779
SW1271 GDSC1 -0.6518 3.0234 -0.8146 60.0426
NCI-H1435 GDSC1 -0.6491 1.2475 -0.6545 61.8533
NCI-H2171 GDSC1 -0.6211 1.6316 -0.6375 61.2571
HOP-62 GDSC1 -0.6148 0.6047 -0.6149 61.6818
NCI-H64 GDSC1 -0.6016 0.4049 -0.6016 61.5371
NCI-H2135 GDSC1 -0.5975 1.7292 -0.6176 60.9164
NCI-H650 GDSC1 -0.5675 0.83 -0.5681 61.062
NCI-H1694 GDSC1 -0.5571 0.8899 -0.5579 60.9207
NCI-H2087 GDSC1 -0.5537 5.33 -1.3048 56.8945
SBC-3 GDSC1 -0.5301 2.1583 -0.5757 59.8132
SBC-5 GDSC1 -0.477 1.9376 -0.5045 59.4328
NCI-H727 GDSC1 -0.4439 4.4128 -0.9042 56.8461
NCI-H187 GDSC1 -0.4296 1.5436 -0.4387 59.1535
NCI-H1568 GDSC1 -0.425 2.3258 -0.4803 58.5628
EMC-BAC-2 GDSC1 -0.3985 1.5217 -0.4064 58.8015
Ms-1 GDSC1 -0.396 0.8333 -0.3962 58.9556
NCI-H1876 GDSC1 -0.3854 1.0991 -0.3867 58.7854
Calu-6 GDSC1 -0.3267 3.2405 -0.5022 56.8101
IST-SL2 GDSC1 -0.2964 1.3974 -0.3002 57.6338
NCI-H2803 GDSC1 -0.2793 1.1824 -0.2807 57.4739
NCI-H1792 GDSC1 -0.2669 2.2124 -0.3049 56.9298
CAL-12T GDSC1 -0.2664 2.7992 -0.3669 56.5432
NCI-H2795 GDSC1 -0.262 1.8811 -0.2796 57.0475
LB647-SCLC GDSC1 -0.2462 2.4936 -0.3086 56.5327
DMS 273 GDSC1 -0.245 2.7574 -0.3384 56.3484
NCI-H82 GDSC1 -0.236 0.5947 -0.236 56.9739
NCI-H841 GDSC1 -0.1942 8.2 -2.0213 53.0959
EKVX GDSC1 -0.1617 3.5302 -0.38 55.0113
NCI-H2029 GDSC1 -0.1595 1.5292 -0.164 55.9478
DMS 114 GDSC1 -0.1349 5.3959 -0.8724 53.7683
HCC78 GDSC1 -0.1344 2.2009 -0.166 55.4381
COR-L303 GDSC1 -0.126 1.7486 -0.1352 55.4923
NCI-H2818 GDSC1 -0.1212 3.103 -0.2568 54.8494
NCI-H524 GDSC1 -0.1065 0.8105 -0.1065 55.3542
NCI-H2196 GDSC1 -0.0924 2.0021 -0.1108 55.0213
NCI-H810 GDSC1 -0.0804 1.2876 -0.0815 55.0117
NCI-H720 GDSC1 -0.005 0.5265 -0.005 54.0865
NCI-H2810 GDSC1 0.0016 2.3126 -0.0325 53.8274
NCI-H2009 GDSC1 0.0187 2.4572 -0.0263 53.5867
NCI-H2141 GDSC1 0.0309 2.9737 -0.0737 53.2858
Lu-139 GDSC1 0.0772 2.1775 0.055 52.966
NCI-H1304 GDSC1 0.094 0.9551 0.094 52.8485
NCI-H526 GDSC1 0.1018 1.2738 0.1014 52.748
NCI-H2731 GDSC1 0.1425 2.4863 0.1009 52.1393
NCI-H23 GDSC1 0.1489 3.393 -0.0163 51.892
NCI-H1436 GDSC1 0.1652 3.8883 -0.1038 51.6208
BEN GDSC1 0.1684 3.8009 -0.0801 51.6053
NCI-H1944 GDSC1 0.2146 5.7558 -0.6202 50.8857
NCI-H661 GDSC1 0.2193 3.1274 0.1051 51.1635
LXF 289 GDSC1 0.2267 2.9535 0.1384 51.0987
NCI-H1836 GDSC1 0.2418 2.8983 0.1617 50.9313
Lu-135 GDSC1 0.2502 1.9905 0.241 50.8855
NCI-H1770 GDSC1 0.3045 1.4598 0.304 50.2178
NCI-H520 GDSC1 0.3287 4.0043 0.0465 49.9294
COR-L311 GDSC1 0.497 6.695 -0.6755 48.6649
Lu-99A GDSC1 0.542 2.3088 0.5275 47.2879
NCI-H2081 GDSC1 0.5558 3.7626 0.35 47.4321
NCI-H1563 GDSC1 0.5632 4.4022 0.1977 47.5408
NCI-H1869 GDSC1 0.5657 7.3726 -0.8805 48.2679
NCI-H1155 GDSC1 0.6086 3.859 0.3858 46.8685
NCI-H1781 GDSC1 0.621 8.3789 -1.2549 48.0841
NCI-H146 GDSC1 0.6223 3.6385 0.4484 46.6342
COR-L321 GDSC1 0.6313 2.4277 0.6136 46.1912
NCI-H2869 GDSC1 0.647 3.4212 0.5165 46.2677
LCLC-103H GDSC1 0.7112 3.1457 0.6292 45.3951
IST-SL1 GDSC1 0.7337 5.1164 0.1634 46.0804
NCI-H2461 GDSC1 0.779 4.8317 0.305 45.468
NCI-H1355 GDSC1 0.7878 4.0614 0.5329 44.931
SBC-1 GDSC1 0.7967 3.7728 0.6096 44.6645
NCI-H1666 GDSC1 0.8076 2.492 0.7921 43.9984
COR-L88 GDSC1 0.839 4.5263 0.4632 44.641
NCI-H2347 GDSC1 0.8472 4.4308 0.4996 44.4885
NCI-H1651 GDSC1 0.8495 6.8825 -0.3797 45.905
HCC33 GDSC1 0.8638 3.3142 0.7676 43.6053
NCI-H1105 GDSC1 0.8761 3.4295 0.7621 43.5171
NCI-H1703 GDSC1 0.9045 2.4168 0.8949 42.7669
Lu-65 GDSC1 0.9112 6.5685 -0.1868 45.2182
CPC-N GDSC1 0.9582 2.4584 0.9483 42.0991
NCI-H835 GDSC1 1.0232 4.6214 0.6359 42.6699
EMC-BAC-1 GDSC1 1.0651 3.9533 0.8611 41.596
PaCa-3 GDSC1 1.0969 7.3925 -0.3361 44.1799
NCI-H2030 GDSC1 1.138 4.5727 0.7757 41.3173
NCI-H1915 GDSC1 1.1748 4.8678 0.7241 41.2046
NCI-H2444 GDSC1 1.232 6.0313 0.3668 41.8221
LOU-NH91 GDSC1 1.2502 5.2637 0.6723 40.8052
NCI-H358 GDSC1 1.2836 6.9712 0.0373 42.2569
NCI-H2722 GDSC1 1.3041 4.7087 0.9153 39.5426
COR-L23 GDSC1 1.3292 5.9759 0.4919 40.7895
NCI-H2373 GDSC1 1.3398 4.4206 1.04 38.7681
RERF-LC-MS GDSC1 1.3407 3.9195 1.1689 38.1759
NCI-H1734 GDSC1 1.3695 4.393 1.0801 38.3756
DMS 53 GDSC1 1.4763 9.5685 -0.933 42.897
NCI-H2066 GDSC1 1.5356 7.3057 0.1542 40.3612
PC-14 GDSC1 1.5706 5.6133 0.8891 37.7532
NCI-H290 GDSC1 1.6296 7.1202 0.3318 39.2796
NCI-H2591 GDSC1 1.6884 6.8356 0.5156 38.3351
NCI-H292 GDSC1 1.718 5.6084 1.0485 36.1001
COR-L105 GDSC1 1.7185 8.3761 -0.1406 40.0205
NCI-H322M GDSC1 1.7207 7.0435 0.459 38.3197
NCI-H209 GDSC1 1.7325 3.1547 1.7092 32.5129
NCI-H647 GDSC1 1.7376 4.6288 1.4122 34.1974
HCC827 GDSC1 1.8075 6.5626 0.7557 36.731
NCI-H2595 GDSC1 1.8603 7.6155 0.3479 37.8375
NCI-H226 GDSC1 1.8704 3.906 1.7475 31.4092
Lu-165 GDSC1 1.9166 7.0612 0.6524 36.4546
NCI-H2369 GDSC1 2.099 7.3095 0.7272 35.0967
SK-LU-1 GDSC1 2.164 9.6173 -0.2853 38.0171
NCI-H1793 GDSC1 2.1779 5.7214 1.4929 31.0059
COLO 668 GDSC1 2.2029 6.3113 1.2735 32.026
NCI-H1755 GDSC1 2.2394 4.9591 1.848 28.541
NCI-H2804 GDSC1 2.2646 7.7996 0.6693 34.3961
A-549 GDSC1 2.2887 5.8041 1.576 29.8873
COR-L95 GDSC1 2.3169 3.7695 2.2561 25.4502
NCI-H3122 GDSC1 2.3992 6.9278 1.2029 31.265
NCI-H596 GDSC1 2.4627 5.9224 1.7089 28.1156
NCI-H1975 GDSC1 2.4721 8.5447 0.5233 33.8627
Lu-134-A GDSC1 2.4843 5.4678 1.9187 26.6904
NCI-H1573 GDSC1 2.4896 7.123 1.2051 30.758
NCI-H522 GDSC1 2.4974 6.6404 1.4314 29.5234
NCI-H1623 GDSC1 2.5327 13.6072 -1.8848 39.7169
KNS-62 GDSC1 2.6029 8.0177 0.9001 31.6146
NCI-H441 GDSC1 2.6368 8.2269 0.8338 31.7367
NCI-H1838 GDSC1 2.7609 8.1536 0.9886 30.3985
Calu-3 GDSC1 2.764 7.7812 1.1688 29.5005
SW1573 GDSC1 3.1149 9.955 0.4455 31.0841
RERF-LC-Sq1 GDSC1 3.1714 12.0241 -0.5255 34.1613
NCI-H3255 GDSC1 3.2636 8.6388 1.2285 26.78
HCC44 GDSC1 3.4054 8.9534 1.2041 26.2692
NCI-H345 GDSC1 3.4195 8.2121 1.5817 24.0847
NCI-H1092 GDSC1 3.5906 10.4528 0.6275 28.2641
NCI-H2405 GDSC1 3.899 10.1661 1.0404 25.0354
HARA [Human squamous cell lung carcinoma] GDSC1 4.1422 19.2771 -3.3059 36.8212
NCI-H2228 GDSC1 4.1493 8.7797 1.9476 18.7262
NCI-H1993 GDSC1 4.2259 10.1263 1.3393 22.1491
NCI-H460 GDSC1 4.2298 12.3234 0.2441 27.4063
EBC-1 GDSC1 4.3136 12.2707 0.3406 26.703
NCI-H513 GDSC1 4.334 11.4439 0.771 24.6956
NCI-H2291 GDSC1 4.4126 13.7866 -0.3351 28.9428
NCI-H1299 GDSC1 4.4824 13.85 -0.309 28.6146
HCC15 GDSC1 4.5129 10.7615 1.2599 21.5255
NCI-H196 GDSC1 4.7016 10.9713 1.3081 20.586
SHP-77 GDSC1 4.7124 10.365 1.6193 18.7327
IA-LM GDSC1 4.7851 11.4812 1.1206 21.3205
NCI-H1650 GDSC1 5.2395 13.8636 0.2926 23.7925
NCI-H2170 GDSC1 5.5032 13.8121 0.5217 21.9597
NCI-H2023 GDSC1 5.5935 8.6693 3.0945 5.9046
NCI-H1437 GDSC1 5.855 18.1156 -1.3426 27.8089
SK-MES-1 GDSC1 6.3275 15.0892 0.5044 19.6774
NCI-H2122 GDSC1 6.5349 12.3313 1.9773 11.1653
NCI-H2172 GDSC1 6.7522 8.1814 3.8634 0.1916
RERF-LC-KJ GDSC1 7.4627 18.8488 -0.5197 21.0608
NCI-H838 GDSC1 7.4733 15.4842 1.0978 13.9319
NCI-H2110 GDSC1 7.5655 9.8198 3.5893 0.5319
ChaGo-K-1 GDSC1 7.9574 16.4233 0.9661 13.5387
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -0.8642 0.9102 -0.8668 64.5378
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 680N GDSC1 -1.837 2.1025 -1.949 70.8372
TE-5 GDSC1 -1.4317 1.5596 -1.4709 69.1775
TE-15 GDSC1 -1.2607 4.0302 -1.6934 63.211
TE-8 GDSC1 -1.1665 3.1156 -1.3868 64.0907
KYSE-450 GDSC1 -0.8792 2.082 -0.9349 63.3765
OE19 GDSC1 -0.3883 1.8854 -0.4099 58.4862
EC-GI-10 GDSC1 -0.2912 2.8739 -0.4038 56.7434
KYSE-270 GDSC1 -0.047 2.0913 -0.0686 54.4588
KYSE-140 GDSC1 0.0387 4.5484 -0.4163 52.6558
TE-6 GDSC1 0.0652 4.7866 -0.4583 52.3443
KYSE-150 GDSC1 0.0998 2.6049 0.0449 52.6143
TE-4 GDSC1 0.1403 2.5121 0.0963 52.1613
TE-9 GDSC1 0.2683 3.9336 -0.0022 50.5582
TE-10 GDSC1 0.4383 3.7961 0.2147 48.7435
T.T GDSC1 0.6749 5.4046 0.0012 46.7821
KYSE-520 GDSC1 1.2753 10.3254 -1.4849 44.6479
KYSE-70 GDSC1 1.622 6.4838 0.5954 38.4899
TE-11 GDSC1 1.884 6.0845 1.0354 35.0932
OE33 GDSC1 2.1317 7.3086 0.7607 34.7747
TE-1 GDSC1 2.201 6.6809 1.1111 32.8359
KYSE-410 GDSC1 2.2876 5.6959 1.619 29.6448
OE21 GDSC1 2.5375 11.6446 -0.9153 37.8166
KYSE-180 GDSC1 2.8417 11.9155 -0.7694 36.1779
KYSE-510 GDSC1 3.0143 11.3792 -0.348 34.2874
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TOV-112D GDSC1 -1.5245 1.8102 -1.5876 69.3679
A2780 GDSC1 -0.5582 1.5321 -0.5694 60.6321
Caov-3 GDSC1 -0.5535 1.8596 -0.5791 60.3282
TYK-nu GDSC1 -0.4808 2.8896 -0.6092 58.6055
OVK18 GDSC1 -0.4555 0.8834 -0.456 59.683
OVISE GDSC1 -0.1923 1.2643 -0.1937 56.3934
RMG-I GDSC1 -0.1767 1.7804 -0.188 56.0874
ES-2 GDSC1 -0.1231 0.6684 -0.1231 55.5626
JHOS-4 GDSC1 -0.0747 6.4853 -1.2018 52.8972
OAW42 GDSC1 0.2068 2.7599 0.1414 51.3492
JHOS-2 GDSC1 0.3266 3.4687 0.1615 49.9482
DOV13 GDSC1 0.363 2.3159 0.3425 49.4983
FU-OV-1 GDSC1 0.4205 3.0235 0.3357 48.8488
OAW28 GDSC1 0.4376 2.7746 0.3838 48.6196
IGROV-1 GDSC1 0.8654 9.0826 -1.3196 46.6822
OV56 GDSC1 1.0876 7.0296 -0.1916 44.0053
Kuramochi GDSC1 1.089 7.9338 -0.5795 44.589
OV-90 GDSC1 1.1502 4.8872 0.6911 41.5006
OVTOKO GDSC1 1.1553 4.2966 0.8729 40.8369
OC 314 GDSC1 1.1856 4.1313 0.9493 40.3067
OVCAR-8 GDSC1 1.9308 6.3298 0.9825 35.0362
TOV-21G GDSC1 1.9309 3.4645 1.8869 30.1646
Caov-4 GDSC1 2.3054 6.4383 1.3245 31.1708
SK-OV-3 GDSC1 2.4888 8.1546 0.7242 32.9722
EFO-21 GDSC1 2.7557 11.2991 -0.5447 35.9552
OVCAR-4 GDSC1 3.5932 11.401 0.1581 30.1782
OVCAR-3 GDSC1 3.9328 12.5677 -0.1296 29.9257
OVKATE GDSC1 4.1848 22.9256 -5.0944 39.0573
EFO-27 GDSC1 4.4361 13.5055 -0.1751 28.2923
OVCAR-5 GDSC1 4.8708 10.253 1.8004 17.0653
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MIA PaCa-2 GDSC1 -0.9137 0.8291 -0.9158 65.1593
KP-4 GDSC1 -0.4364 0.8587 -0.4368 59.4515
MZ-PC-1 GDSC1 -0.1025 4.2423 -0.485 54.059
KP-1N GDSC1 -0.0233 2.2094 -0.0511 54.1468
SU.86.86 GDSC1 0.0553 0.8631 0.0552 53.3333
HuP-T4 GDSC1 0.1749 1.7497 0.1706 51.8234
Panc 03.27 GDSC1 0.6319 2.1268 0.6259 46.1481
Capan-2 GDSC1 0.7834 10.3673 -1.99 47.5279
Capan-1 GDSC1 1.0184 4.0635 0.7839 42.2466
SUIT-2 GDSC1 1.027 4.0447 0.7978 42.1297
HuP-T3 GDSC1 1.2949 7.0079 0.0336 42.1904
Panc 04.03 GDSC1 1.7582 6.5706 0.7011 37.2459
PaTu 8988t GDSC1 2.2084 10.8237 -0.8232 39.0812
PSN1 GDSC1 2.2713 7.5639 0.7846 33.891
Panc 02.03 GDSC1 2.3083 7.4315 0.8824 33.2694
QGP-1 GDSC1 2.5112 7.8883 0.8715 32.2209
CFPAC-1 GDSC1 2.5899 6.6479 1.5219 28.5148
BxPC-3 GDSC1 2.6171 5.4666 2.0595 25.0407
PL4 GDSC1 3.104 8.2267 1.2804 27.2482
Panc 08.13 GDSC1 3.3857 8.9742 1.1759 26.5057
YAPC GDSC1 3.3948 7.7723 1.774 23.0194
KP-3 GDSC1 3.9958 9.2543 1.5789 21.6564
PaTu 8902 GDSC1 4.1464 19.1623 -3.245 36.7132
HPAC GDSC1 4.438 8.3221 2.4177 14.3804
Hs 766T GDSC1 4.7296 9.9099 1.86 17.1681
HPAF-II GDSC1 5.3653 11.9193 1.3539 18.1343
AsPC-1 GDSC1 5.6278 11.4483 1.7798 14.8134
DAN-G GDSC1 6.4588 16.8049 -0.2407 22.4768
Panc 10.05 GDSC1 6.9025 10.4074 3.0654 3.5815
SW1990 GDSC1 7.3381 15.7468 0.8853 15.3129
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 -0.156 0.906 -0.1561 55.9708
MSTO-211H GDSC1 0.1336 2.8622 0.0512 52.1733
MPP 89 GDSC1 0.2 2.6583 0.1452 51.4406
NCI-H2052 GDSC1 1.2467 4.2211 0.9928 39.6622
NCI-H2452 GDSC1 1.451 7.0782 0.1655 40.866
NCI-H28 GDSC1 1.7018 5.5098 1.0686 36.1175
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1 -0.6424 1.3679 -0.6504 61.697
VCaP GDSC1 -0.031 1.9671 -0.046 54.3015
LNCaP clone FGC GDSC1 0.3174 3.1301 0.2099 50.0517
PC-3 GDSC1 0.5186 3.5575 0.3522 47.8005
22Rv1 GDSC1 0.8423 3.4292 0.7257 43.9291
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 3.1829 9.037 0.9589 28.5143
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CP50-MEL-B GDSC1 -3.384 -2.0734 -3.384 92.7699
UACC-62 GDSC1 -2.9347 -2.3198 -2.9347 90.4709
A101D GDSC1 -2.4323 -1.1331 -2.4323 83.5796
SK-MEL-3 GDSC1 -2.3454 -1.1944 -2.3454 82.8463
WM115 GDSC1 -1.9688 0.2926 -1.9734 76.4248
WT2-iPS GDSC1 -1.8478 7.8334 -3.6139 61.3423
G-361 GDSC1 -1.832 -0.5662 -1.832 76.6374
WM35 GDSC1 -1.7524 -0.5519 -1.7524 75.7309
SK-MEL-5 GDSC1 -1.4706 -0.0405 -1.4708 72.1382
SK-MEL-28 GDSC1 -1.461 1.9988 -1.539 68.4731
SK-MEL-2 GDSC1 -1.4567 -0.0635 -1.4568 71.9988
WM278 GDSC1 -1.4523 -0.2616 -1.4523 72.0672
CHL-1 GDSC1 -1.3738 0.2175 -1.3744 70.8319
IPC-298 GDSC1 -1.2383 1.7959 -1.2867 67.0849
MMAc-SF GDSC1 -1.233 0.5448 -1.2346 68.9657
Mel JuSo GDSC1 -1.2241 0.592 -1.2261 68.8206
A-431 GDSC1 -1.2135 1.378 -1.2349 67.6074
MZ-MEL-7 GDSC1 -1.191 -0.3218 -1.191 68.9027
A-375 GDSC1 -1.1238 0.3929 -1.1244 67.8647
MZ-MEL-2 GDSC1 -1.0951 1.7135 -1.1315 65.9527
Hs 938.T GDSC1 -1.0655 0.5296 -1.0663 67.103
IGR-1 GDSC1 -1.0071 0.4722 -1.0076 66.4579
A-388 GDSC1 -1.003 2.7697 -1.1509 63.4046
COLO 792 GDSC1 -0.9228 0.0959 -0.9229 65.5445
HT-144 GDSC1 -0.8733 0.9244 -0.8761 64.6313
Mel Ho GDSC1 -0.8535 0.9379 -0.8564 64.3967
SH-4 GDSC1 -0.8044 0.8972 -0.8064 63.8577
RPMI-7951 GDSC1 -0.7906 0.9215 -0.7928 63.6836
SK-MEL-30 GDSC1 -0.7781 1.189 -0.784 63.3571
G-mel GDSC1 -0.7708 0.7912 -0.7719 63.5187
SK-MEL-24 GDSC1 -0.7079 2.104 -0.7572 61.6856
UACC-257 GDSC1 -0.7014 3.7839 -1.0232 59.5445
LB373-MEL-D GDSC1 -0.622 2.2063 -0.6762 60.709
DJM-1 GDSC1 -0.54 4.8261 -1.1298 57.2257
RVH-421 GDSC1 -0.51 1.1079 -0.5121 60.2883
A2058 GDSC1 -0.4915 1.2266 -0.4948 60.024
WM793 GDSC1 -0.4357 1.4638 -0.4427 59.2633
COLO 679 GDSC1 -0.3865 1.0869 -0.3877 58.8017
WM1552C GDSC1 -0.3643 1.413 -0.3693 58.4425
LOX-IMVI GDSC1 -0.3451 2.0427 -0.3744 57.9042
CP66-MEL GDSC1 -0.3011 1.7585 -0.3145 57.5565
Hs 940.T GDSC1 -0.2568 1.6976 -0.267 57.0632
451Lu GDSC1 -0.1938 3.0089 -0.3198 55.6547
COLO 800 GDSC1 -0.1082 2.1046 -0.1327 55.1721
VMRC-MELG GDSC1 0.036 1.6803 0.0312 53.5388
COLO 829 GDSC1 0.1525 3.6212 -0.058 51.8064
M14 GDSC1 0.2154 2.0775 0.2021 51.3085
MeWo GDSC1 0.3004 4.4589 -0.105 50.2107
IGR-37 GDSC1 0.4496 3.1752 0.3448 48.5268
LB2518-MEL GDSC1 0.6348 3.0569 0.5597 46.2936
GAK GDSC1 0.827 3.7159 0.6546 44.2736
IST-MEL1 GDSC1 0.8674 4.1519 0.5969 44.0759
HMV-II GDSC1 0.8907 3.8338 0.6985 43.591
COLO 783 GDSC1 1.3642 4.2704 1.108 38.2886
SK-MEL-1 GDSC1 2.9013 12.7832 -1.144 36.8353
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -0.932 1.0647 -0.9375 65.1683
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh41 GDSC1 -1.9086 -0.9435 -1.9086 77.7851
Hs 633.T GDSC1 -1.8448 -1.1227 -1.8448 77.0683
Rh30 GDSC1 -1.7068 0.689 -1.7155 73.3436
GCT GDSC1 -1.4314 0.9625 -1.4424 70.3547
KYM-1 GDSC1 -1.0941 0.5277 -1.0951 67.4323
SK-LMS-1 GDSC1 -1.0831 0.8621 -1.0871 67.0128
SW872 GDSC1 -1.0378 0.4145 -1.0382 66.8488
HT-1080 GDSC1 -0.976 1.1991 -0.9854 65.501
MES-SA GDSC1 -0.8217 2.977 -0.9897 61.5819
SK-UT-1 GDSC1 -0.8073 3.6877 -1.1162 60.4987
SW982 GDSC1 -0.6715 0.7797 -0.6722 62.3353
A-204 GDSC1 -0.5067 1.4436 -0.5143 60.0984
RD GDSC1 -0.504 2.0404 -0.5394 59.6419
VA-ES-BJ GDSC1 -0.3454 1.6126 -0.3548 58.1392
G-401 GDSC1 -0.1839 1.3124 -0.1857 56.2839
Rh18 GDSC1 0.1826 0.9974 0.1826 51.7419
SW684 GDSC1 0.5005 12.2903 -3.168 49.2047
G-402 GDSC1 0.5443 2.0782 0.5381 47.2391
MFH-ino GDSC1 0.6744 3.9805 0.429 46.1758
EW-8 GDSC1 0.8795 2.4758 0.8669 43.092
RKN GDSC1 1.2164 3.1667 1.1642 39.1056
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GCIY GDSC1 -3.4405 -2.2484 -3.4405 93.653
HSC-39 GDSC1 -2.3488 -0.2797 -2.3504 80.8261
SNU-1 GDSC1 -1.6613 -0.7715 -1.6613 74.7559
Fu97 GDSC1 -1.5606 0.6277 -1.566 72.162
MKN1 GDSC1 -1.5559 1.1142 -1.575 71.1508
HGC-27 GDSC1 -1.3869 1.62 -1.4285 68.6831
Hs 746.T GDSC1 -1.0479 0.4163 -1.0483 66.9656
AGS GDSC1 -0.9072 0.8152 -0.9092 65.0947
RF-48 GDSC1 -0.8438 1.7752 -0.8747 63.4444
ECC10 GDSC1 -0.7101 0.8009 -0.711 62.7922
MKN7 GDSC1 -0.4977 3.385 -0.7149 58.2646
SNU-5 GDSC1 -0.453 1.3512 -0.4579 59.5174
SCH GDSC1 -0.2765 1.7211 -0.288 57.2865
IM95 GDSC1 0.1242 2.7725 0.0523 52.298
MKN28 GDSC1 0.1494 5.427 -0.5751 51.4701
KATO III GDSC1 0.3336 5.1471 -0.281 49.8947
23132/87 GDSC1 0.4051 1.5204 0.4046 48.9616
NUGC-4 GDSC1 0.5917 2.6407 0.5582 46.7199
TGBC11TKB GDSC1 1.0875 5.9393 0.2484 43.1523
OCUM-1 GDSC1 1.1047 4.5115 0.7573 41.6407
NCI-N87 GDSC1 1.2936 6.7499 0.1408 41.9556
RERF-GC-1B GDSC1 1.5238 6.9931 0.2775 40.1017
NUGC-3 GDSC1 1.9064 7.348 0.5147 37.0112
SNU-16 GDSC1 2.5152 5.6023 1.8969 26.6575
MKN45 GDSC1 4.4704 7.898 2.6561 12.5057
SNG-M GDSC1 -2.2061 -1.4773 -2.2061 81.552
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-133 GDSC1 -3.3606 -2.5705 -3.3606 94.4758
HTC-C3 GDSC1 -2.5589 -1.2713 -2.5589 84.9985
IHH-4 GDSC1 -2.0561 -1.2415 -2.0561 79.6672
K5 GDSC1 -1.9408 -0.4368 -1.9409 77.6342
8505C GDSC1 -1.8649 -0.134 -1.8655 76.4
KMH-2 GDSC1 -1.7293 -0.2193 -1.7296 75.1523
B-CPAP GDSC1 -1.6123 -0.3934 -1.6124 74.0131
CAL-62 GDSC1 -1.4946 0.4734 -1.4973 71.7862
8305C GDSC1 -0.9469 0.6565 -0.948 65.6538
TT2609-C02 GDSC1 -0.3761 3.5632 -0.6197 57.0019
BHT-101 GDSC1 0.1773 1.0868 0.1773 51.8076
WRO GDSC1 0.3361 5.5083 -0.4012 49.8774
CGTH-W-1 GDSC1 0.4467 4.0811 0.1561 48.6952
TT GDSC1 0.4613 6.3955 -0.5955 48.9034
ASH-3 GDSC1 0.5041 2.2956 0.4892 47.7563
ML-1 [Human leukemia] GDSC1 1.5258 8.1883 -0.2487 41.3766
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SKN-3 GDSC1 -3.1264 -0.5749 -3.1302 86.1085
SCC-9 GDSC1 -2.1846 -0.0653 -2.1869 79.0217
SCC-15 GDSC1 -1.9452 -0.6743 -1.9452 77.9865
BB30-HNC GDSC1 -1.2303 1.0786 -1.2409 68.2489
Ca9-22 GDSC1 -1.0354 3.0522 -1.2333 63.2047
SCC-25 GDSC1 -0.8969 1.1324 -0.9034 64.7211
BHY GDSC1 -0.8576 3.2464 -1.0775 61.4989
BICR 10 GDSC1 -0.8446 1.8626 -0.8813 63.3405
BB49-HNC GDSC1 -0.7041 7.6508 -2.3294 56.157
LB771-HNC GDSC1 -0.4925 0.8535 -0.493 60.1416
PE/CA-PJ15 GDSC1 -0.4051 2.2747 -0.4547 58.3934
PCI-04B GDSC1 -0.1984 3.9099 -0.5052 55.1219
NCI-H3118 GDSC1 -0.0706 4.2222 -0.4449 53.78
OSC-20 GDSC1 -0.057 5.3811 -0.7831 53.1634
PCI-30 GDSC1 0.0345 4.1512 -0.3116 52.8311
HSC-2 GDSC1 0.1455 1.1211 0.1454 52.2048
PCI-15A GDSC1 0.1888 2.4789 0.15 51.594
KON GDSC1 0.3571 5.8936 -0.5169 49.7093
HSC-3 GDSC1 0.3973 2.5066 0.3656 49.0866
DOK GDSC1 0.5538 5.1154 -0.0314 47.839
PCI-06A GDSC1 0.8416 3.4049 0.7291 43.9242
SAT [Human HNSCC] GDSC1 0.9 6.8085 -0.2962 45.4477
OSC-19 GDSC1 1.32 7.5045 -0.1543 42.4267
CAL-33 GDSC1 1.4821 6.1001 0.605 39.3836
Detroit 562 GDSC1 1.5408 6.561 0.4782 39.4002
BICR 31 GDSC1 1.5601 7.6519 0.0267 40.5363
HO-1-N-1 GDSC1 1.6264 4.602 1.2993 35.5282
CAL-27 GDSC1 1.6709 6.8249 0.502 38.4901
BICR 22 GDSC1 1.8066 2.9288 1.7993 31.487
JHU-011 GDSC1 2.0475 4.8474 1.6787 30.7248
BICR 78 GDSC1 2.0617 7.5705 0.5714 35.9064
JHU-022 GDSC1 2.2549 5.5218 1.654 29.6299
HSC-4 GDSC1 2.8873 3.3823 2.8865 17.9377
PCI-38 GDSC1 3.5903 5.0539 3.2499 11.5418
KOSC-2 GDSC1 3.9165 10.0714 1.1027 24.643
SCC-4 GDSC1 3.952 10.3159 1.0113 24.9719
HO-1-u-1 GDSC1 4.535 15.6845 -1.1828 31.1798
FaDu GDSC1 5.2016 13.7695 0.3097 23.8378
SAS GDSC1 7.2526 9.3049 3.6544 0.4958
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 GDSC1 -1.0438 0.2488 -1.044 66.9898
BFTC-905 GDSC1 -0.6846 6.2653 -1.7731 57.0006
RT-112 GDSC1 -0.1164 4.4978 -0.5709 54.0528
5637 GDSC1 0.1495 2.7619 0.0804 52.0113
SW1710 GDSC1 0.3705 3.249 0.2481 49.4473
HT-1197 GDSC1 0.4812 4.3269 0.1291 48.3772
639V GDSC1 0.5733 3.7062 0.3811 47.2181
SW780 GDSC1 0.9446 3.4332 0.8352 42.68
TCCSUP GDSC1 0.9895 5.9118 0.1543 44.0736
HT-1376 GDSC1 1.5879 7.384 0.1736 39.9855
T24 GDSC1 1.5915 4.2691 1.3564 35.47
647V GDSC1 1.7397 4.313 1.5063 33.6667
KU-19-19 GDSC1 2.0507 8.4322 0.1637 37.3383
J82 GDSC1 2.8177 6.8905 1.6393 26.633
RT-4 GDSC1 2.9469 5.2935 2.4775 20.4141
CAL-29 GDSC1 4.1883 8.2672 2.2369 16.6019
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
C-33 A GDSC1 -2.6269 -0.7129 -2.6275 84.0144
C-4-I GDSC1 -1.9459 1.7998 -2.03 72.2965
SW756 GDSC1 -1.7911 -0.2157 -1.7914 75.7919
PA-1 GDSC1 -1.7892 -0.7844 -1.7892 76.2979
NEC8 GDSC1 -1.6312 0.8982 -1.6442 72.2489
HT-3 GDSC1 -1.6237 -0.1577 -1.6239 73.9469
HeLa GDSC1 -1.5347 0.643 -1.5401 71.8928
TC-YIK GDSC1 -1.4359 0.9272 -1.446 70.4605
DoTc2 4510 GDSC1 -1.362 1.4722 -1.3931 68.7674
LB831-BLC GDSC1 -1.2553 1.8727 -1.3109 67.0853
ME-180 GDSC1 -1.2237 2.2294 -1.3133 66.1473
Ca Ski GDSC1 -1.083 1.1884 -1.094 66.6211
NCC-IT GDSC1 -0.8668 1.6662 -0.8921 63.8124
UWB1.289 GDSC1 -0.8386 3.3139 -1.0702 61.2508
OVCA433 GDSC1 -0.6714 0.9233 -0.6729 62.2833
NT2-D1 GDSC1 -0.4682 1.9563 -0.4966 59.3227
HEY GDSC1 -0.4126 0.8171 -0.4129 59.1629
SKN GDSC1 -0.4096 2.3782 -0.4691 58.3574
MS751 GDSC1 -0.3924 2.8374 -0.5069 57.7912
JAR GDSC1 -0.3121 1.8088 -0.3279 57.6608
HEC-1 GDSC1 -0.2201 5.3408 -0.9463 54.4521
CAL-39 GDSC1 0.0972 3.205 -0.0387 52.4942
KGN GDSC1 0.1825 1.9376 0.1736 51.719
PWR-1E GDSC1 0.2086 1.8061 0.2035 51.4051
OV17R GDSC1 0.2273 3.9153 -0.0425 50.9825
SW954 GDSC1 0.3081 4.2655 -0.0432 50.1391
SiSo GDSC1 0.3824 2.6678 0.3363 49.276
BPH-1 GDSC1 0.6279 5.7541 -0.1746 47.344
SW962 GDSC1 0.9314 4.9864 0.4211 43.9665
DSH1 GDSC1 0.9507 3.1161 0.8883 42.4241
OVMIU GDSC1 1.3034 5.165 0.7643 40.1038
JEG-3 GDSC1 1.4085 6.1251 0.5171 40.1642
PEO1 GDSC1 1.4372 5.8794 0.6444 39.5603
ACC-OV7 GDSC1 1.6734 5.2761 1.1245 36.0542
SiHa GDSC1 1.9117 6.7644 0.7771 36.0059
OVCA420 GDSC1 2.8741 5.5248 2.3053 22.0021
OMC-1 [Human cervical carcinoma] GDSC1 2.9924 3.842 2.9683 16.7723
JHOS-3 GDSC1 4.4696 12.3625 0.424 25.7885
SKG-IIIa GDSC1 6.0085 19.5145 -1.9186 28.9933
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 Activation of histamine H4 receptor inhibits TNFalpha/IMD-0354-induced apoptosis in human salivary NS-SV-AC cells. Apoptosis. 2014 Dec;19(12):1702-11.
2 I B kinase beta inhibitor IMD-0354 suppresses airway remodelling in a Dermatophagoides pteronyssinus-sensitized mouse model of chronic asthma. Clin Exp Allergy. 2011 Jan;41(1):104-15.