Details of the Drug

General Information of Drug (ID: DMOH8VY)

Drug Name
Dacomitinib
Synonyms PF-00299804
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Approved [1]
Affected Organisms
Humans and other mammals
ATC Code
L01EB07: Dacomitinib
L01EB: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 469.9
Logarithm of the Partition Coefficient (xlogp) 4.4
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 3000 mcgh/L []
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 2 mcg/L []
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1.5 h []
Bioavailability
The bioavailability of drug is 60-80% []
Clearance
The clearance of drug is 27.06 L/h [2]
Elimination
79% is recovered in feces, and 3% is recovered in urine [2]
Half-life
The concentration or amount of drug in body reduced by one-half in 70 hours [3]
Metabolism
The drug is metabolized via the glutathione and cytochrome P450 enzymes [4]
Vd
The volume of distribution (Vd) of drug is 2415 L [2]
Chemical Identifiers
Formula
C24H25ClFN5O2
IUPAC Name
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide
Canonical SMILES
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4
InChI
InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+
InChIKey
LVXJQMNHJWSHET-AATRIKPKSA-N
Cross-matching ID
PubChem CID
11511120
ChEBI ID
CHEBI:91466
CAS Number
1110813-31-4
UNII
2XJX250C20
DrugBank ID
DB11963
TTD ID
D06XXH
VARIDT ID
DR00109
INTEDE ID
DR0407
ACDINA ID
D00982
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Antagonist [5]
Erbb2 tyrosine kinase receptor (HER2) TT6EO5L ERBB2_HUMAN Antagonist [6]
Erbb4 tyrosine kinase receptor (Erbb-4) TT0JESD ERBB4_HUMAN Antagonist [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2D6 (CYP2D6)
Main DME 		DECB0K3 CP2D6_HUMAN Substrate [7]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [7]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Non-small-cell lung cancer
ICD Disease Classification 2C25.Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Epidermal growth factor receptor (EGFR) DTT EGFR 5.84E-05 0.32 0.55
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 1.14E-01 -7.61E-02 -3.24E-01
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 4.60E-34 -1.33E+00 -2.50E+00
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 5.04E-04 -9.90E-02 -3.91E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 3.3221 4.6022 3.1431 13.702
EW-24 GDSC1 -0.7417 5.2015 -1.4672 58.2952
NOS-1 [Human HNSCC] GDSC1 0.3809 2.2977 0.362 49.2779
ES7 GDSC1 0.425 2.4793 0.3965 48.7471
ES4 GDSC1 0.7572 8.5273 -1.1809 47.2164
EW-13 GDSC1 0.8812 2.2732 0.8757 43.0379
ES1 GDSC1 1.0556 3.0258 1.0098 41.0619
U2OS GDSC1 1.0773 3.1669 1.0166 40.8635
EW-7 GDSC1 1.2425 2.5692 1.2351 38.5371
NY GDSC1 1.2667 3.4821 1.1737 38.6916
HuO9 GDSC1 1.3381 2.9303 1.3149 37.4354
EW-18 GDSC1 1.3651 2.9936 1.3381 37.1202
H-EMC-SS GDSC1 1.4229 4.1747 1.197 37.4489
SK-ES-1 GDSC1 1.4964 3.1957 1.4573 35.5548
CHSA8926 GDSC1 1.627 3.8644 1.492 34.4887
CADO-ES1 GDSC1 1.6493 3.1205 1.6251 33.5576
ES5 GDSC1 1.7554 4.1935 1.555 33.2871
EW-16 GDSC1 1.7945 4.8788 1.3937 33.9243
EW-1 GDSC1 1.908 3.8041 1.8087 30.7963
EW-22 GDSC1 1.9927 3.1099 1.9824 29.1798
SaOS-2 GDSC1 2.1728 3.8568 2.0852 27.4224
EW-3 GDSC1 2.2826 3.4135 2.2634 25.6126
SK-PN-DW GDSC1 2.3565 3.89 2.2777 25.0728
MHH-ES-1 GDSC1 2.3797 3.5448 2.3531 24.4462
G-292 clone A141B1 GDSC1 2.4233 4.1599 2.2918 24.5842
HOS GDSC1 2.5216 3.5615 2.5009 22.6348
CAL-78 GDSC1 2.5343 3.4096 2.5254 22.401
ES8 GDSC1 2.5941 3.6362 2.5699 21.7509
HuO-3N1 GDSC1 2.6388 3.8362 2.5912 21.343
CAL-72 GDSC1 2.6773 3.3407 2.6747 20.5743
SJSA-1 GDSC1 2.7917 3.3473 2.7905 19.1348
ES6 GDSC1 2.8614 4.587 2.6485 19.6749
MG-63 GDSC1 3.3701 4.1817 3.3178 12.2367
TC-71 GDSC1 3.5464 4.361 3.4646 10.2331
A-673 GDSC1 3.7952 4.2116 3.773 6.7274
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 152 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 2.2329 3.5396 2.1985 26.3308
DoHH2 GDSC1 -0.4051 2.094 -0.4402 58.5302
Ramos.2G6.4C10 GDSC1 -0.1786 4.1295 -0.5384 54.8061
SU-DHL-6 GDSC1 -0.0691 1.7009 -0.0759 54.8169
CTV-1 GDSC1 0.0536 1.7547 0.0474 53.3156
MOLT-16 GDSC1 0.2111 2.0336 0.1995 51.3631
SIG-M5 GDSC1 0.4285 2.6571 0.3858 48.7183
MV4-11 GDSC1 0.4893 1.9225 0.4856 47.9172
KE-37 GDSC1 0.572 1.8185 0.5705 46.8798
SU-DHL-16 GDSC1 0.667 1.747 0.6664 45.6897
ALL-PO GDSC1 0.7057 2.4225 0.6905 45.2627
A4/Fukuda GDSC1 0.7361 3.3663 0.622 45.183
PF-382 GDSC1 0.7422 2.2121 0.7359 44.7752
Karpas-45 GDSC1 0.7896 2.4667 0.7748 44.22
697 GDSC1 0.8941 2.4959 0.881 42.9129
CCRF-CEM GDSC1 0.9092 2.208 0.9056 42.6784
OCI-AML-2 GDSC1 0.9466 2.4415 0.9371 42.2419
RPMI-8402 GDSC1 0.9645 1.959 0.9639 41.9712
Loucy GDSC1 1.0181 2.2479 1.015 41.3159
QIMR-WIL GDSC1 1.0529 2.5803 1.0404 40.9316
CA46 GDSC1 1.0867 2.69 1.0696 40.5347
Ku812 GDSC1 1.0947 2.1409 1.0936 40.3471
SU-DHL-5 GDSC1 1.1775 2.2427 1.176 39.3144
ALL-SIL GDSC1 1.1899 2.4803 1.1842 39.184
HAL-01 GDSC1 1.217 2.8369 1.1955 38.9348
MOLT-13 GDSC1 1.2335 2.659 1.2224 38.6708
HEL GDSC1 1.2485 2.9042 1.2234 38.562
OCI-Ly19 GDSC1 1.2489 2.929 1.2219 38.5673
P32/ISH GDSC1 1.2627 2.7319 1.249 38.3214
Jurkat GDSC1 1.2693 2.9977 1.2375 38.3405
SUP-B15 GDSC1 1.292 3.5793 1.1844 38.4545
HC-1 GDSC1 1.3814 2.9458 1.3589 36.8908
VAL GDSC1 1.3899 2.8184 1.3758 36.7356
GDM-1 GDSC1 1.3926 3.4305 1.3169 37.0506
Karpas-231 GDSC1 1.4029 2.8798 1.3857 36.5918
MOLT-4 GDSC1 1.4052 2.8704 1.3886 36.5594
MY-M12 GDSC1 1.4263 3.1247 1.3906 36.4083
P30/OHK GDSC1 1.4637 2.7754 1.4538 35.7886
WIL2 NS GDSC1 1.4682 2.8331 1.4558 35.7477
RCH-ACV GDSC1 1.4791 3.2003 1.4386 35.7782
SU-DHL-10 GDSC1 1.4806 2.1149 1.4806 35.5167
NB4 GDSC1 1.4843 2.6505 1.4793 35.5012
NK-92MI GDSC1 1.5438 2.7624 1.5364 34.7723
NOMO-1 GDSC1 1.5495 2.668 1.5451 34.6823
SUP-T1 GDSC1 1.557 2.9287 1.5423 34.6517
LAMA-84 GDSC1 1.5726 3.4554 1.506 34.768
Reh GDSC1 1.5838 2.7988 1.5761 34.2746
MC116 GDSC1 1.5889 2.0521 1.5889 34.163
SR GDSC1 1.6083 2.4965 1.6073 33.9267
HH [Human lymphoma] GDSC1 1.6336 4.094 1.447 34.6976
NKM-1 GDSC1 1.6549 2.5258 1.6539 33.3442
CESS GDSC1 1.6992 3.0157 1.6843 32.8768
PL-21 GDSC1 1.7363 4.1258 1.5512 33.4328
ML-2 GDSC1 1.8226 2.4281 1.8225 31.2419
RS4;11 GDSC1 1.8256 3.1806 1.8044 31.3369
SKM-1 GDSC1 1.8371 3.3881 1.7965 31.314
RPMI-6666 GDSC1 1.8422 3.3202 1.8093 31.2027
RPMI-8866 GDSC1 1.8496 2.7433 1.8477 30.9161
BV-173 GDSC1 1.8523 3.3961 1.8117 31.1246
MLMA GDSC1 1.8532 2.456 1.8531 30.86
DB GDSC1 1.8612 2.6393 1.8606 30.7629
H9 GDSC1 1.8635 3.0152 1.854 30.7901
NALM-6 GDSC1 1.8836 3.0024 1.8752 30.5316
Hs 445 GDSC1 1.8836 2.6895 1.8826 30.4855
NU-DUL-1 GDSC1 1.8881 3.4571 1.8424 30.7092
A3/Kawakami GDSC1 1.9262 2.7283 1.9252 29.9532
OCI-AML-5 GDSC1 1.934 5.0029 1.5027 32.4409
CTB-1 GDSC1 1.9361 4.7763 1.5814 31.9826
GA-10 GDSC1 1.9627 2.7549 1.9617 29.4965
ST486 GDSC1 2.0019 3.1705 1.9885 29.0851
L-363 GDSC1 2.005 3.1878 1.9907 29.0517
K-562 GDSC1 2.0056 3.1994 1.9906 29.0484
THP-1 GDSC1 2.0774 3.7251 2.0058 28.5102
HDLM-2 GDSC1 2.0818 3.9526 1.9672 28.7297
OCI-M1 GDSC1 2.0875 3.7763 2.0078 28.4356
P12-Ichikawa GDSC1 2.1077 3.0198 2.1037 27.7028
LC4-1 GDSC1 2.1123 3.5864 2.0643 27.9243
DEL GDSC1 2.118 2.6648 2.118 27.5493
HL-60 GDSC1 2.1199 3.3474 2.0986 27.6591
KY821 GDSC1 2.1616 3.0904 2.1565 27.0363
DND-41 GDSC1 2.162 3.4524 2.133 27.1822
HT GDSC1 2.1741 3.0986 2.169 26.8796
Sc-1 GDSC1 2.2188 3.6484 2.1693 26.6034
KOPN-8 GDSC1 2.2257 3.2972 2.2126 26.2852
BALL-1 GDSC1 2.2281 3.7397 2.1655 26.5716
EoL-1 GDSC1 2.2343 3.4418 2.2102 26.2473
MEG-01 GDSC1 2.2405 3.7715 2.1736 26.4441
JSC-1 GDSC1 2.2955 3.5036 2.2685 25.501
BC-1 GDSC1 2.2968 3.4285 2.2769 25.4396
Farage GDSC1 2.3336 3.1942 2.3287 24.8846
MOLP-8 GDSC1 2.3557 3.281 2.3479 24.627
JURL-MK1 GDSC1 2.3861 3.882 2.3111 24.6781
ME1 GDSC1 2.3908 3.4374 2.3745 24.2417
SU-DHL-4 GDSC1 2.3983 3.0119 2.3977 24.0495
KMOE-2 GDSC1 2.3985 3.8797 2.3249 24.5143
Karpas-620 GDSC1 2.4135 3.2205 2.4095 23.8807
EM-2 GDSC1 2.4155 3.4482 2.3995 23.931
Karpas-422 GDSC1 2.4294 3.6977 2.3875 23.9232
MOLM-13 GDSC1 2.4491 3.2499 2.4449 23.4369
U266B1 GDSC1 2.462 3.3121 2.4557 23.2883
U-698-M GDSC1 2.4643 3.6034 2.4363 23.3979
RPMI-8226 GDSC1 2.4718 3.8277 2.4131 23.502
TUR GDSC1 2.4891 3.5451 2.4684 23.0411
IM-9 GDSC1 2.4943 3.1663 2.4927 22.8555
GR-ST GDSC1 2.4994 3.8303 2.4424 23.146
Daudi GDSC1 2.5146 3.8777 2.4507 23.0009
KCL-22 GDSC1 2.516 3.6183 2.4893 22.7429
L-428 GDSC1 2.5168 3.7004 2.4803 22.7956
MN-60 GDSC1 2.5245 3.4415 2.5134 22.5372
SK-MM-2 GDSC1 2.526 3.4541 2.5141 22.5242
SU-DHL-8 GDSC1 2.5322 3.4694 2.5195 22.4516
KMS-12-BM GDSC1 2.5599 3.2952 2.5565 22.0468
KG-1 GDSC1 2.57 4.4278 2.3801 23.1456
EB2 GDSC1 2.577 3.3158 2.5733 21.8344
BL-41 GDSC1 2.5844 3.1964 2.5833 21.7259
L-1236 GDSC1 2.6238 5.6145 2.006 25.3569
OPM-2 GDSC1 2.6364 4.1417 2.5284 21.7695
Mono-Mac-6 GDSC1 2.704 3.8503 2.6591 20.511
ATN-1 GDSC1 2.7291 3.3602 2.7269 19.9244
Jiyoye GDSC1 2.7564 3.5639 2.7461 19.634
BE-13 GDSC1 2.7801 3.5269 2.7729 19.3176
SUP-HD1 GDSC1 2.8039 3.75 2.7793 19.1313
LP-1 GDSC1 2.8384 3.5283 2.8328 18.5791
SU-DHL-1 GDSC1 2.8385 3.1968 2.8385 18.5432
MHH-PREB-1 GDSC1 2.8843 3.5178 2.8803 17.9954
ROS-50 GDSC1 2.9003 3.6784 2.8877 17.8497
EHEB GDSC1 2.9254 3.6116 2.9184 17.5007
VL51 GDSC1 2.9441 3.9942 2.8934 17.5483
SUP-M2 GDSC1 2.9701 3.9233 2.9332 17.1336
WSU-NHL GDSC1 3.0223 3.8678 2.9969 16.4065
RL GDSC1 3.0272 3.7357 3.0158 16.2557
EJM GDSC1 3.0467 3.8397 3.0263 16.0697
P31/FUJ GDSC1 3.152 3.7863 3.1422 14.6858
TK [Human B-cell lymphoma] GDSC1 3.1698 4.0518 3.1267 14.6784
OCI-AML-3 GDSC1 3.1749 4.3243 3.0695 15.0292
Karpas-299 GDSC1 3.1752 4.2808 3.0815 14.9472
Raji GDSC1 3.1864 4.7344 2.9498 15.7964
JJN-3 GDSC1 3.1888 4.0729 3.1433 14.457
SCC-3 GDSC1 3.2746 3.9376 3.2564 13.2075
L-540 GDSC1 3.2978 4.4504 3.1667 13.672
JVM-3 GDSC1 3.336 4.2558 3.2633 12.798
BC-3 GDSC1 3.4128 4.1619 3.3685 11.6499
DG-75 GDSC1 3.4311 4.3957 3.3286 11.8134
YT GDSC1 3.4926 4.2244 3.4416 10.6976
Granta-519 GDSC1 3.5979 4.4105 3.5059 9.6612
RC-K8 GDSC1 3.6061 4.2343 3.5627 9.2295
ARH-77 GDSC1 3.7679 4.3834 3.6995 7.3792
AMO1 GDSC1 3.7863 4.25 3.7554 6.8957
KMS-11 GDSC1 3.8109 4.6959 3.6311 7.6359
KM-H2 GDSC1 3.8795 4.5117 3.7766 6.2306
WSU-DLCL2 GDSC1 4.3381 6.2071 3.3928 7.2682
JVM-2 GDSC1 4.3837 6.8048 3.1316 9.1576
⏷ Show the Full List of 152 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-26 GDSC1 -4.5009 4.6828 -5.4076 74.6495
KYAE-1 GDSC1 -4.2671 1.7814 -4.5 81.1204
KYSE-220 GDSC1 -0.214 12.8665 -4.1392 52.1683
TE-12 GDSC1 -0.093 5.4615 -0.8494 53.4139
OACP4 C GDSC1 1.605 5.4365 0.9922 37.0975
FLO-1 GDSC1 2.1113 3.7145 2.044 28.0603
KYSE-50 GDSC1 2.3612 3.9387 2.2732 25.0736
OACM5.1 C GDSC1 2.9557 3.9758 2.9092 17.376
SK-GT-4 GDSC1 3.1055 9.9477 0.4405 31.1465
HCE-4 GDSC1 3.3239 4.6731 3.12 13.8547
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 3.7415 4.5361 3.6194 8.0823
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC1 -0.7484 4.46 -1.2498 59.12
SK-N-SH GDSC1 -0.2682 2.6377 -0.348 56.6732
KP-N-YS GDSC1 -0.1572 1.8816 -0.172 55.8241
NB69 GDSC1 0.1076 3.8963 -0.1685 52.1989
GOTO GDSC1 0.8238 1.6939 0.8237 43.7275
SJNB-12 GDSC1 0.9172 1.8763 0.9168 42.5616
Kelly GDSC1 1.2192 2.3055 1.2173 38.7957
SiMa GDSC1 1.3771 2.3443 1.3761 36.8165
SJNB-14 GDSC1 1.3959 2.2162 1.3956 36.5771
NB1 GDSC1 1.5822 2.9397 1.5678 34.3356
NB(TU)1 GDSC1 1.5983 2.9775 1.5821 34.1454
LA-N-6 GDSC1 1.8695 2.4673 1.8695 30.6553
MHH-NB-11 GDSC1 2.3626 3.625 2.3258 24.7251
CHP-134 GDSC1 2.395 3.3922 2.3822 24.1671
GI-ME-N GDSC1 2.7029 5.8744 1.9789 25.109
SJNB-7 GDSC1 2.7564 3.5503 2.7471 19.6278
KP-N-YN GDSC1 2.8279 3.9704 2.7722 19.0329
TGW GDSC1 2.8789 3.6266 2.8693 18.0981
IMR-5 GDSC1 3.1123 7.7521 1.5177 25.8862
SJNB-17 GDSC1 3.2132 4.3227 3.1118 14.5246
SK-N-MC-IXC GDSC1 3.2799 4.0998 3.2367 13.3031
SK-N-BE(2)-M17 GDSC1 3.4571 9.4453 1.0081 27.0469
SK-N-FI GDSC1 3.5986 4.6821 3.4115 10.3209
SK-N-DZ GDSC1 3.766 4.2801 3.7262 7.2084
NH-12 GDSC1 3.8025 4.5556 3.6777 7.3435
SJNB-13 GDSC1 3.8178 4.5187 3.7078 7.0482
SK-N-AS GDSC1 3.8194 4.2563 3.79 6.4723
SJNB-6 GDSC1 3.8208 4.6889 3.6445 7.4875
SJNB-5 GDSC1 3.8472 4.3268 3.8025 6.2275
SJNB-10 GDSC1 3.8579 4.5343 3.745 6.5701
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 0.9291 2.5897 0.9123 42.4947
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AU565 GDSC1 -6.3104 0.7445 -6.5364 86.7882
BT-474 GDSC1 -5.2529 -0.1756 -5.3251 88.6306
HCC2218 GDSC1 -4.971 10.11 -7.8288 67.9391
MDA-MB-175-VII GDSC1 -4.2869 4.3449 -5.0794 74.8227
HCC1419 GDSC1 -3.3856 5.9608 -4.588 69.3292
OCUB-M GDSC1 -2.0651 1.8653 -2.163 72.8413
UACC-893 GDSC1 -0.8848 3.0746 -1.0748 61.9677
HCC202 GDSC1 0.3465 9.1374 -1.8706 49.8579
Hs 578T GDSC1 0.4848 2.1644 0.4748 47.9854
MDA-MB-330 GDSC1 0.4911 14.6416 -4.2972 49.3635
HCC1599 GDSC1 0.5341 1.6705 0.5335 47.3498
HCC1806 GDSC1 0.5639 2.6647 0.5271 47.0671
HCC1187 GDSC1 0.8638 2.4202 0.8532 43.2788
MDA-MB-468 GDSC1 0.8973 2.4579 0.886 42.8644
EFM-192A GDSC1 1.0762 15.6108 -4.2125 47.236
DU4475 GDSC1 1.188 2.0249 1.1878 39.1756
EFM-19 GDSC1 1.3707 3.5743 1.2701 37.4537
HCC1954 GDSC1 1.4049 7.0995 0.1086 41.3032
COLO 824 GDSC1 1.4779 6.3522 0.4986 39.7521
ZR-75-30 GDSC1 1.5345 7.9675 -0.1404 41.0866
CAL-85-1 GDSC1 1.5853 9.6496 -0.8637 42.2139
HCC1500 GDSC1 1.6867 2.6747 1.6841 32.9567
MRK-nu-1 GDSC1 1.6969 2.8536 1.6897 32.8578
HCC38 GDSC1 1.7815 3.3153 1.7457 31.9786
MDA-MB-453 GDSC1 1.848 4.2622 1.6381 32.2089
HDQ-P1 GDSC1 1.8513 3.2887 1.822 31.0662
HCC1569 GDSC1 1.8571 4.9448 1.4393 33.2764
HCC1395 GDSC1 1.8648 2.7089 1.8635 30.722
HCC2157 GDSC1 1.9721 4.7858 1.6173 31.55
MDA-MB-361 GDSC1 1.9929 3.6479 1.9274 29.5263
UACC-812 GDSC1 2.0032 9.5958 -0.4305 39.1899
CAL-148 GDSC1 2.1439 4.1425 1.9915 28.1989
HCC1937 GDSC1 2.2487 4.1068 2.1143 26.7794
HCC1428 GDSC1 2.2695 3.2622 2.26 25.7149
BT-549 GDSC1 2.3196 5.162 1.861 27.9916
CAMA-1 GDSC1 2.3895 5.2274 1.9114 27.2716
HCC70 GDSC1 2.4501 3.5062 2.4309 23.519
BT-483 GDSC1 2.4776 6.6212 1.42 29.6945
Evsa-T GDSC1 2.4908 3.4052 2.4808 22.952
MDA-MB-231 GDSC1 2.6827 3.3792 2.6791 20.5128
MDA-MB-436 GDSC1 2.7198 4.1621 2.6143 20.712
MCF-7 GDSC1 2.7412 4.3687 2.5839 20.7929
MFM-223 GDSC1 2.8243 3.8772 2.7839 18.9782
CAL-51 GDSC1 2.9229 4.8336 2.6301 19.466
MDA-MB-415 GDSC1 2.9515 3.6548 2.9428 17.1852
YMB-1-E GDSC1 3.1382 4.6659 2.9221 16.2508
BT-20 GDSC1 3.3629 4.5375 3.2094 13.0157
MDA-MB-157 GDSC1 3.3906 4.3233 3.3052 12.2022
CAL-120 GDSC1 3.5908 6.5974 2.5294 16.9443
T-47D GDSC1 5.6046 14.9093 0.0555 23.6745
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PFSK-1 GDSC1 2.0034 3.3584 1.9753 29.1588
D-336MG GDSC1 2.0216 3.5075 1.978 29.0291
D283 Med GDSC1 2.2253 3.2405 2.2155 26.269
KS-1 [Human Krukenberg tumour] GDSC1 2.3042 4.987 1.9081 27.7838
DK-MG GDSC1 2.4117 3.5423 2.3872 24.0328
YKG-1 GDSC1 2.5314 3.212 2.5295 22.3933
GaMG GDSC1 2.5385 3.2842 2.535 22.3145
MOG-G-CCM GDSC1 2.5663 3.6346 2.5407 22.1069
GI-1 GDSC1 2.5722 3.6608 2.5441 22.0497
U-251MG GDSC1 2.6204 3.1575 2.62 21.2716
Daoy GDSC1 2.6309 3.2164 2.6299 21.144
NMC-G1 GDSC1 2.6324 4.6382 2.3829 22.7736
SW1783 GDSC1 2.6954 3.662 2.6742 20.4657
SF539 GDSC1 2.7279 3.2203 2.7275 19.9275
SK-MG-1 GDSC1 2.7296 3.5226 2.721 19.958
H4 GDSC1 2.7566 3.4669 2.7515 19.5985
LN-18 GDSC1 2.7672 3.1566 2.7672 19.4339
LN-229 GDSC1 2.773 3.2989 2.7722 19.3665
KINGS-1 GDSC1 2.7973 3.755 2.7717 19.2207
D-423MG GDSC1 2.8108 4.476 2.6283 20.0966
AM-38 GDSC1 2.8184 3.6482 2.8046 18.8812
CAS-1 GDSC1 2.8358 3.7406 2.814 18.7147
8-MG-BA GDSC1 2.9294 4.0176 2.8732 17.7676
ONS-76 GDSC1 3.0617 4.038 3.0124 16.0698
SF126 GDSC1 3.1354 4.2448 3.0472 15.4068
YH-13 GDSC1 3.1577 3.7959 3.1473 14.6183
D-542MG GDSC1 3.221 4.0247 3.1866 13.9811
GB-1 GDSC1 3.2511 4.8846 2.9628 15.3601
U-87MG ATCC GDSC1 3.3354 3.9875 3.3148 12.4629
D-502MG GDSC1 3.4136 7.6876 1.8329 22.5606
D-263MG GDSC1 3.4229 4.6783 3.2248 12.5827
42-MG-BA GDSC1 3.4236 4.4575 3.3015 12.0415
Onda 11 GDSC1 3.4318 4.8163 3.1818 12.8432
SF295 GDSC1 3.4569 4.1495 3.4188 11.0582
D-392MG GDSC1 3.4885 4.7372 3.2728 11.893
M059J GDSC1 3.4915 4.421 3.3868 11.0756
D-566MG GDSC1 3.5305 4.2585 3.4747 10.2564
SF268 GDSC1 3.5634 4.7129 3.3621 10.8601
KALS-1 GDSC1 3.5763 4.6328 3.4062 10.4769
U-118MG GDSC1 3.5775 4.41 3.4839 9.9264
DBTRG-05MG GDSC1 3.6088 4.2039 3.5724 9.1497
MOG-G-UVW GDSC1 3.6106 4.502 3.49 9.7011
Onda 10 GDSC1 3.6383 4.3436 3.5698 8.9962
SW1088 GDSC1 3.6712 4.3734 3.597 8.6245
D-247MG GDSC1 3.6744 4.6222 3.5154 9.1788
SNB-75 GDSC1 3.6831 4.7374 3.4796 9.3916
LN-405 GDSC1 3.7171 4.3418 3.6564 7.9599
LNZTA3WT4 GDSC1 3.7423 4.3611 3.6783 7.6681
KNS-81-FD GDSC1 3.782 4.3611 3.7216 7.1481
Hs 683 GDSC1 3.8258 4.2397 3.8005 6.3652
T98G GDSC1 3.847 4.3241 3.8031 6.2248
A-172 GDSC1 3.8553 4.3353 3.809 6.1379
Becker GDSC1 3.9078 4.529 3.8004 5.9114
KNS-42 GDSC1 3.9124 4.367 3.8619 5.4542
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 0.9116 2.4402 0.9014 42.6812
TGBC24TKB GDSC1 1.5356 8.1368 -0.2155 41.2475
TGBC1TKB GDSC1 4.0669 4.67 3.9071 4.3304
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 -0.3607 3.9603 -0.6943 56.5317
MFE-280 GDSC1 1.3857 4.9208 0.9361 38.8625
MFE-319 GDSC1 2.4244 3.3446 2.4155 23.7753
KLE GDSC1 2.933 11.7815 -0.6204 35.4066
EN GDSC1 3.5154 4.0803 3.494 10.2187
ESS-1 GDSC1 3.6015 4.1623 3.5728 9.1896
MFE-296 GDSC1 3.6489 4.6103 3.4926 9.4764
AN3-CA GDSC1 3.6506 8.3938 1.7027 22.334
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW13 GDSC1 -1.7744 5.7686 -2.7758 63.4423
769-P GDSC1 -1.7625 6.5676 -3.0431 62.3594
KTCTL-140 GDSC1 0.0078 6.1163 -0.9744 52.4193
TK-10 GDSC1 0.1234 10.8644 -2.8767 50.9619
KTCTL-21 GDSC1 0.9525 3.2759 0.8685 42.4886
VMRC-RCZ GDSC1 0.9763 2.3972 0.969 41.8596
LB996-RCC GDSC1 1.461 6.9089 0.2484 40.5842
NCC021 GDSC1 2.0378 3.7451 1.9597 29.0457
KTCTL-195 GDSC1 2.3366 3.6167 2.2992 25.0541
LB2241-RCC GDSC1 2.4319 4.5594 2.1899 25.2101
KTCTL-26A GDSC1 2.5273 3.4772 2.5139 22.5173
786-O GDSC1 2.5377 3.6108 2.513 22.4589
KMRC-1 GDSC1 2.5412 3.8488 2.4843 22.623
CAL-54 GDSC1 2.5892 9.4549 0.1993 34.4543
KTCTL-13 GDSC1 2.6409 3.6387 2.6191 21.1508
ACHN GDSC1 2.6434 29.1104 -9.4975 45.2401
A-704 GDSC1 2.7198 3.9184 2.6649 20.3784
KTCTL-1M GDSC1 2.8423 3.7092 2.8242 18.61
Caki-1 GDSC1 2.8572 14.1842 -1.8774 38.4868
SN12C GDSC1 2.8708 4.0995 2.793 18.642
BB65-RCC GDSC1 2.9288 3.6942 2.9162 17.4937
HA7-RCC GDSC1 3.0107 4.0783 2.9493 16.7858
SW156 GDSC1 3.1343 4.6087 2.9376 16.1646
LB1047-RCC GDSC1 3.1486 4.631 2.9454 16.0314
KMRC-20 GDSC1 3.2423 4.3347 3.1402 14.1667
OS-RC-2 GDSC1 3.2771 9.1788 0.9759 28.0035
RCC10RGB GDSC1 3.2832 4.7233 3.0581 14.511
UO-31 GDSC1 3.361 5.1701 2.9625 14.7984
VMRC-RCW GDSC1 3.7763 4.3175 3.7277 7.1391
RXF 393L GDSC1 3.9203 6.3704 2.9464 12.3808
A-498 GDSC1 3.9436 4.5345 3.8364 5.465
BFTC-909 GDSC1 3.947 5.4699 3.4118 8.6621
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CCK-81 GDSC1 -4.8949 2.9931 -5.4075 79.1767
SNU-175 GDSC1 -0.4727 4.838 -1.0601 56.7131
HT115 GDSC1 -0.4435 34.2348 -14.7705 51.2058
LoVo GDSC1 0.9103 6.6439 -0.2182 45.2688
SNU-C2B GDSC1 1.436 13.0732 -2.6423 44.9939
NCI-H747 GDSC1 2.1452 8.2551 0.3395 36.2575
SNU-1040 GDSC1 2.4264 5.6073 1.8013 27.7543
LS513 GDSC1 2.5055 5.683 1.8536 26.9852
SW1116 GDSC1 2.5435 20.5524 -5.3192 43.3934
HCT 116 GDSC1 2.555 3.2626 2.5523 22.1037
GP5d GDSC1 2.5684 4.8696 2.235 24.1348
RKO GDSC1 2.5724 3.8861 2.5116 22.2585
LS411N GDSC1 2.6519 5.1357 2.2269 23.7277
COLO 320HSR GDSC1 2.7401 3.4871 2.7337 19.8134
COLO205 GDSC1 2.7724 3.2309 2.7721 19.3711
HCT 15 GDSC1 2.8644 4.3673 2.7187 19.1773
C2BBe1 GDSC1 2.9763 4.5737 2.7777 18.1455
SW626 GDSC1 3.0646 4.0779 3.0079 16.0815
SW837 GDSC1 3.1162 8.7425 1.0409 28.4229
HT-29 GDSC1 3.1755 4.222 3.0966 14.8437
SW1417 GDSC1 3.2079 4.1418 3.1502 14.2984
NCI-H716 GDSC1 3.2491 4.2672 3.1656 13.9554
CaR-1 GDSC1 3.46 4.407 3.3568 11.4579
CL-11 GDSC1 3.5347 4.6487 3.3558 11.0565
KM12 GDSC1 3.6791 5.136 3.3048 10.7005
SNU-81 GDSC1 3.7248 11.1739 0.3864 28.7476
SNU-407 GDSC1 3.7717 9.6328 1.1951 24.7456
COLO 678 GDSC1 3.8119 4.9733 3.5125 8.5085
SNU-61 GDSC1 3.8451 15.5906 -1.7145 34.7312
HCC2998 GDSC1 3.87 5.9524 3.1051 11.3654
RCM-1 [Human ESC] GDSC1 3.9287 13.3464 -0.522 31.2606
SW948 GDSC1 3.9867 4.6802 3.8208 5.3619
CW-2 GDSC1 4.0659 8.4259 2.0528 18.3492
SW48 GDSC1 4.3357 5.5107 3.7389 4.5484
SW620 GDSC1 4.3446 5.9997 3.5019 6.3855
SNU-C5 GDSC1 4.388 5.8265 3.624 5.2697
LS1034 GDSC1 4.4398 6.0878 3.5352 5.7909
SNU-C1 GDSC1 4.4829 6.295 3.4661 6.1879
T84 GDSC1 4.6392 8.1547 2.6631 11.8679
LS180 GDSC1 4.6718 30.4834 -8.4684 40.9318
HT-55 GDSC1 5.1135 22.5844 -4.1583 35.6505
LS123 GDSC1 5.8183 14.3826 0.4777 21.2253
MDST8 GDSC1 5.8236 7.2514 3.84 0.7682
SW1463 GDSC1 8.3304 23.9434 -2.3821 24.9597
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.5001 4.6065 3.3339 11.3971
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-4 GDSC1 -1.2824 3.2481 -1.538 64.6846
SNU-475 GDSC1 1.5245 2.3881 1.5239 34.9718
JHH-2 GDSC1 1.7005 7.0514 0.4348 38.5223
SNU-449 GDSC1 2.4378 14.0618 -2.1953 40.561
Huh-7 GDSC1 2.4806 3.8615 2.4169 23.4244
SNU-423 GDSC1 2.5183 6.0218 1.7243 27.7143
JHH-7 GDSC1 2.9014 3.8019 2.8765 17.9144
SNU-398 GDSC1 3.1899 5.1495 2.7921 16.9066
Hep 3B2.1-7 GDSC1 3.5009 5.4346 2.9901 13.9089
Hep-G2/C3A GDSC1 3.5835 4.322 3.516 9.6733
HLE GDSC1 3.5918 5.2151 3.1807 12.0488
SNU-387 GDSC1 3.7169 4.4058 3.637 8.094
JHH-1 GDSC1 3.7726 61.6771 -24.8146 46.7374
SK-HEP-1 GDSC1 3.7971 4.1227 3.7887 6.6139
JHH-6 GDSC1 3.9912 6.1387 3.1251 10.7045
HuH-1 GDSC1 4.8714 6.2561 3.7654 2.7523
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Calu-3 GDSC1 -5.251 7.7423 -7.2249 71.3042
HCC827 GDSC1 -5.1045 11.2096 -8.4153 67.1363
NCI-H1623 GDSC1 -4.5903 15.479 -9.7217 62.9379
NCI-H3255 GDSC1 -2.914 4.3356 -3.5786 70.7236
NCI-H1781 GDSC1 -2.3841 2.799 -2.6441 72.0483
NCI-H1568 GDSC1 -1.5588 16.7497 -7.2821 55.5146
COR-L105 GDSC1 -1.094 9.898 -3.6817 56.6834
PaCa-3 GDSC1 -0.5856 5.365 -1.3511 57.0868
NCI-H1648 GDSC1 -0.361 9.469 -2.7406 53.575
NCI-H1975 GDSC1 -0.347 4.954 -0.959 55.6655
NCI-H322M GDSC1 0.0789 12.1088 -3.4966 51.0625
NCI-H661 GDSC1 0.1962 16.9079 -5.6705 50.404
CAL-12T GDSC1 1.0437 13.853 -3.391 47.0243
PC-14 GDSC1 1.0744 6.6954 -0.0664 43.876
RERF-LC-Sq1 GDSC1 1.3763 11.5636 -1.9734 44.6621
NCI-H1869 GDSC1 1.3913 9.7411 -1.0973 43.582
NCI-H69 GDSC1 1.5096 3.3001 1.4595 35.4551
NCI-H524 GDSC1 1.6421 2.9893 1.6268 33.5928
LCLC-97TM1 GDSC1 1.6587 4.4164 1.3891 34.8444
Ms-1 GDSC1 1.7808 2.6436 1.7796 31.772
NCI-H358 GDSC1 1.7811 12.9225 -2.2439 43.1976
COR-L303 GDSC1 1.82 3.0924 1.8048 31.3687
EKVX GDSC1 1.8666 9.0218 -0.2931 39.5747
EPLC-272H GDSC1 1.9394 3.3092 1.9127 29.9489
IST-SL2 GDSC1 1.9519 3.7586 1.8647 30.1739
NCI-H727 GDSC1 1.9524 4.9586 1.5378 32.1291
NCI-H211 GDSC1 2.0686 3.3133 2.0478 28.2977
NCI-H1341 GDSC1 2.1118 4.5838 1.8337 29.3903
NCI-H847 GDSC1 2.1432 2.9362 2.1415 27.2447
NCI-H1048 GDSC1 2.1555 3.9189 2.0542 27.7262
NCI-H1876 GDSC1 2.2585 3.9523 2.1591 26.4295
CPC-N GDSC1 2.2592 3.4989 2.2307 25.9641
Lu-135 GDSC1 2.2717 3.5761 2.2353 25.8588
Lu-139 GDSC1 2.2744 3.6577 2.2275 25.8917
NCI-H835 GDSC1 2.3023 4.0312 2.1899 25.9679
ABC-1 GDSC1 2.3074 3.6531 2.2633 25.4615
NCI-H2444 GDSC1 2.3673 4.2294 2.2133 25.4308
NCI-H2171 GDSC1 2.3769 3.2514 2.371 24.35
NCI-H2347 GDSC1 2.3914 4.4713 2.1725 25.5595
NCI-H1435 GDSC1 2.4107 4.0047 2.3135 24.5161
NCI-H2342 GDSC1 2.4156 7.4222 0.9938 32.1802
NCI-H1944 GDSC1 2.4218 3.761 2.3701 24.0809
NCI-H2087 GDSC1 2.4577 4.3492 2.2799 24.4628
NCI-H226 GDSC1 2.474 3.2015 2.4715 23.1152
NCI-H64 GDSC1 2.4782 3.4146 2.4671 23.116
HCC33 GDSC1 2.4796 3.3746 2.4708 23.0845
Calu-6 GDSC1 2.4972 3.7786 2.4483 23.1206
HCC78 GDSC1 2.5284 3.8223 2.4749 22.7603
SW1271 GDSC1 2.5303 5.0478 2.1296 25.0539
NCI-H510A GDSC1 2.5348 3.7015 2.4994 22.5639
SBC-3 GDSC1 2.5349 3.5695 2.5142 22.4684
NCI-H522 GDSC1 2.5482 5.1779 2.0999 25.1516
LC-2/ad GDSC1 2.5785 3.8409 2.5258 22.1296
IST-SL1 GDSC1 2.5829 3.544 2.5668 21.8393
NCI-H441 GDSC1 2.5865 4.7059 2.3108 23.5201
NCI-H23 GDSC1 2.5888 3.5477 2.5727 21.7657
LB647-SCLC GDSC1 2.5946 3.5249 2.5805 21.6799
NCI-H1304 GDSC1 2.5989 3.4197 2.5915 21.5841
NCI-H82 GDSC1 2.6434 3.4787 2.6344 21.0381
NCI-H520 GDSC1 2.6507 3.3946 2.6458 20.921
NCI-H596 GDSC1 2.6546 3.4635 2.6468 20.8908
NCI-H1770 GDSC1 2.6629 3.2376 2.662 20.7438
NCI-H1792 GDSC1 2.6709 4.2308 2.5442 21.4638
EMC-BAC-1 GDSC1 2.6776 14.5361 -2.2129 39.7044
NCI-H2795 GDSC1 2.6996 3.8458 2.655 20.5641
NCI-H650 GDSC1 2.7043 3.4882 2.6968 20.2674
NCI-H146 GDSC1 2.7095 3.7652 2.6771 20.361
NCI-H290 GDSC1 2.7336 4.4843 2.5416 21.1233
NCI-H1666 GDSC1 2.7416 16.6859 -3.2219 40.872
NCI-H1581 GDSC1 2.7565 3.9867 2.692 19.9824
NCI-H720 GDSC1 2.7722 3.4587 2.7679 19.3985
NCI-H446 GDSC1 2.7822 3.3302 2.7811 19.2533
LK-2 GDSC1 2.7828 3.4024 2.7804 19.2539
UMC-11 GDSC1 2.7845 3.9234 2.7336 19.5439
NCI-H2731 GDSC1 2.8004 3.5777 2.791 19.0783
NCI-H2141 GDSC1 2.8049 4.179 2.7031 19.6244
NCI-H1105 GDSC1 2.8184 3.4997 2.8135 18.8248
HOP-62 GDSC1 2.837 3.6931 2.8201 18.6687
NCI-H2869 GDSC1 2.8428 4.9047 2.518 20.683
NCI-H2081 GDSC1 2.8593 4.0922 2.782 18.7826
SBC-1 GDSC1 2.8619 3.9734 2.8084 18.594
NCI-H1694 GDSC1 2.8745 3.8353 2.8437 18.2891
NCI-H2196 GDSC1 2.887 3.903 2.8473 18.1899
NCI-H209 GDSC1 2.8993 4.9425 2.5647 20.0513
NCI-H2810 GDSC1 2.9019 4.1363 2.8187 18.2898
NCI-H1436 GDSC1 2.9322 3.7216 2.9175 17.4641
COR-L321 GDSC1 2.9773 4.3485 2.8471 17.6638
NCI-H513 GDSC1 2.9949 8.647 0.9737 29.3233
NCI-H2591 GDSC1 3.0082 4.5656 2.8149 17.7111
NCI-H1734 GDSC1 3.0092 4.0089 2.9611 16.7178
EMC-BAC-2 GDSC1 3.0312 3.8635 3.0069 16.2888
NCI-H1915 GDSC1 3.044 4.0279 2.9951 16.2882
NCI-H1688 GDSC1 3.0513 4.202 2.966 16.4376
COR-L23 GDSC1 3.0564 4.2885 2.9498 16.5171
BEN GDSC1 3.057 4.4418 2.907 16.8046
NCI-H292 GDSC1 3.0783 7.2879 1.7077 24.9176
NCI-H1755 GDSC1 3.0919 3.933 3.0623 15.5638
COLO 668 GDSC1 3.0958 4.0177 3.0529 15.602
NCI-H2803 GDSC1 3.1272 4.3595 3.0077 15.7207
NCI-H810 GDSC1 3.1337 3.9753 3.1008 15.0631
NCI-H1155 GDSC1 3.1424 4.2487 3.0539 15.3212
NCI-H2291 GDSC1 3.1511 5.749 2.4941 19.2588
SHP-77 GDSC1 3.1656 3.9936 3.1321 14.6681
NCI-H2030 GDSC1 3.1841 4.7245 2.9509 15.8004
NCI-H1703 GDSC1 3.2202 4.4582 3.0798 14.7031
NCI-H187 GDSC1 3.2671 4.0425 3.2332 13.402
NCI-H2818 GDSC1 3.2731 4.5085 3.1214 14.1222
NCI-H1573 GDSC1 3.2958 4.4001 3.1798 13.5937
NCI-H2595 GDSC1 3.3028 5.2189 2.8813 15.6854
NCI-H647 GDSC1 3.3036 4.6155 3.1186 13.9746
A-427 GDSC1 3.3047 4.4523 3.1736 13.586
COR-L88 GDSC1 3.3057 4.43 3.1816 13.525
LOU-NH91 GDSC1 3.3352 4.5734 3.1672 13.4618
NCI-H1563 GDSC1 3.3387 4.1386 3.2929 12.5858
NCI-H2029 GDSC1 3.3532 4.3904 3.2453 12.8222
NCI-H2009 GDSC1 3.3618 4.6705 3.1618 13.3561
NCI-H1651 GDSC1 3.3766 4.8659 3.1036 13.6933
NCI-H2135 GDSC1 3.3785 5.7784 2.7106 16.5739
NCI-H526 GDSC1 3.386 4.6798 3.1845 13.0662
NCI-H1993 GDSC1 3.4195 12.4722 -0.5277 33.1835
Lu-134-A GDSC1 3.4546 4.442 3.3401 11.6026
NCI-H2170 GDSC1 3.4608 5.0264 3.1271 13.0916
SBC-5 GDSC1 3.4888 4.0277 3.4728 10.5157
DMS 114 GDSC1 3.5106 4.2215 3.4618 10.4585
COR-L311 GDSC1 3.5318 4.572 3.3804 10.8983
Lu-65 GDSC1 3.5766 5.0482 3.2383 11.6948
LCLC-103H GDSC1 3.5825 4.0573 3.5689 9.3292
NCI-H2228 GDSC1 3.5844 5.3293 3.1219 12.5237
NCI-H1793 GDSC1 3.6219 6.1896 2.7555 15.1183
LXF 289 GDSC1 3.639 4.3828 3.5592 9.0648
Lu-99A GDSC1 3.6548 5.0558 3.3155 10.7383
NCI-H2405 GDSC1 3.655 9.5649 1.1259 25.5984
DMS 273 GDSC1 3.6601 4.9695 3.3585 10.3939
NCI-H2722 GDSC1 3.661 4.4527 3.5611 8.9291
NCI-H1650 GDSC1 3.6624 7.9736 1.921 20.8924
NCI-H2461 GDSC1 3.6875 4.4972 3.5749 8.6877
DMS 53 GDSC1 3.6982 4.7757 3.4799 9.3115
NCI-H1355 GDSC1 3.7007 4.4259 3.613 8.3494
NCI-H1838 GDSC1 3.704 10.2304 0.8382 26.8272
NCI-H1092 GDSC1 3.7076 4.4706 3.6057 8.3621
COR-L95 GDSC1 3.7084 4.3152 3.6541 8.025
NCI-H2804 GDSC1 3.7165 4.9373 3.4307 9.5818
IA-LM GDSC1 3.7238 5.042 3.3922 9.8316
NCI-H2066 GDSC1 3.7253 5.5879 3.1422 11.7153
NCI-H460 GDSC1 3.7586 4.157 3.7431 7.1406
A-549 GDSC1 3.7873 5.7214 3.1385 11.4662
HCC44 GDSC1 3.79 4.6459 3.6293 7.7566
NCI-H2369 GDSC1 3.7992 4.2772 3.763 6.77
NCI-H1836 GDSC1 3.7998 4.3052 3.7566 6.8091
NCI-H196 GDSC1 3.8217 4.246 3.7947 6.4271
RERF-LC-MS GDSC1 3.83 4.316 3.7867 6.433
NCI-H2373 GDSC1 3.8529 5.0348 3.526 8.2114
Lu-165 GDSC1 3.8627 4.2925 3.8285 5.9632
SK-LU-1 GDSC1 3.9231 4.5592 3.8049 5.7987
SW1573 GDSC1 3.9997 5.8061 3.2967 9.3326
HCC15 GDSC1 4.0244 5.9928 3.2272 9.7733
ChaGo-K-1 GDSC1 4.0484 5.9472 3.2714 9.3306
NCI-H841 GDSC1 4.0573 5.0041 3.7412 5.6379
NCI-H2023 GDSC1 4.087 4.8374 3.8494 4.6752
KNS-62 GDSC1 4.0912 4.7087 3.9138 4.1653
NCI-H3122 GDSC1 4.2154 5.4479 3.6678 5.5579
EBC-1 GDSC1 4.2848 6.408 3.2478 8.6033
RERF-LC-KJ GDSC1 4.3024 6.5727 3.1802 9.0694
NCI-H345 GDSC1 4.3685 5.1265 3.9578 2.7076
SK-MES-1 GDSC1 4.6892 5.9249 3.802 2.9456
NCI-H2122 GDSC1 4.7818 6.1626 3.7509 3.0855
NCI-H1299 GDSC1 5.5867 7.7946 3.4919 3.1393
NCI-H1437 GDSC1 5.9584 7.5633 3.7778 0.9231
NCI-H2172 GDSC1 6.5978 7.9031 3.9037 0.1594
NCI-H838 GDSC1 6.7734 8.0134 3.9271 0.091
HARA [Human squamous cell lung carcinoma] GDSC1 7.3213 22.3068 -2.3098 26.895
NCI-H2110 GDSC1 7.4411 9.656 3.6006 0.5582
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 1.6251 3.3056 1.5814 33.9781
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE19 GDSC1 -4.1401 3.223 -4.6378 76.979
KYSE-140 GDSC1 -3.6272 12.7759 -7.5428 62.6436
TE-15 GDSC1 -3.0994 6.4347 -4.4388 67.6815
TE-4 GDSC1 -2.3785 4.9544 -3.1725 67.4328
KYSE-450 GDSC1 -1.4648 8.7679 -3.5871 58.9507
KYSE-150 GDSC1 0.141 3.7875 -0.1068 51.8879
TE-6 GDSC1 0.1563 13.0987 -3.8853 50.6771
TE-5 GDSC1 0.9827 2.7178 0.96 41.8562
COLO 680N GDSC1 1.2804 4.2394 1.0248 39.2741
TE-8 GDSC1 1.3017 2.9917 1.272 37.9253
EC-GI-10 GDSC1 1.5485 15.6327 -3.7836 45.3783
KYSE-270 GDSC1 1.8426 11.1769 -1.3411 41.73
KYSE-70 GDSC1 1.9472 3.0707 1.9375 29.7452
KYSE-520 GDSC1 2.1321 4.4001 1.9104 28.7866
TE-10 GDSC1 2.4889 3.9136 2.4163 23.3786
KYSE-180 GDSC1 2.7007 3.9867 2.6316 20.7096
KYSE-410 GDSC1 2.8198 10.0364 0.1332 33.5921
TE-9 GDSC1 2.8434 3.7495 2.8212 18.622
OE33 GDSC1 2.8624 8.4217 0.9573 30.0424
KYSE-510 GDSC1 2.9764 7.3502 1.5794 26.1879
OE21 GDSC1 2.983 4.2277 2.8854 17.3727
T.T GDSC1 3.4739 4.4034 3.3729 11.2693
TE-1 GDSC1 3.5441 4.8734 3.2778 11.5689
TE-11 GDSC1 3.7131 4.741 3.5098 9.018
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RMG-I GDSC1 0.4027 11.1167 -2.7149 49.6075
JHOS-4 GDSC1 0.719 4.226 0.4157 45.7917
OAW28 GDSC1 2.2364 10.0198 -0.4087 37.9784
Kuramochi GDSC1 2.42 6.372 1.4712 29.732
FU-OV-1 GDSC1 2.4449 10.9822 -0.6778 37.669
A2780 GDSC1 2.4722 3.6866 2.4346 23.3603
TOV-112D GDSC1 2.5159 3.6737 2.4828 22.7855
Caov-3 GDSC1 2.5912 3.4204 2.5836 21.682
ES-2 GDSC1 2.7294 3.8187 2.691 20.1515
OVCAR-3 GDSC1 2.7376 11.5618 -0.6904 36.4157
Caov-4 GDSC1 2.8832 4.4442 2.7167 19.0847
TYK-nu GDSC1 2.9214 3.9584 2.8752 17.8022
OC 314 GDSC1 2.992 5.1695 2.5753 19.4854
EFO-21 GDSC1 3.2076 7.9907 1.4925 25.58
DOV13 GDSC1 3.3051 5.5385 2.7447 16.6766
SK-OV-3 GDSC1 3.3335 4.0464 3.304 12.5436
IGROV-1 GDSC1 3.3474 4.2108 3.2865 12.5771
TOV-21G GDSC1 3.4468 4.3867 3.3484 11.5894
OV-90 GDSC1 3.5335 4.1149 3.5079 10.0195
OVTOKO GDSC1 3.6688 4.4866 3.5583 8.9058
OVCAR-4 GDSC1 3.7094 15.7829 -1.9267 35.6328
OVK18 GDSC1 3.7983 4.4851 3.6988 7.2162
OVCAR-5 GDSC1 3.8491 4.4116 3.7789 6.3793
OV56 GDSC1 3.8549 4.1867 3.8418 5.9214
OVCAR-8 GDSC1 3.8733 5.3569 3.3955 9.112
OAW42 GDSC1 4.0884 5.2332 3.6596 6.1355
JHOS-2 GDSC1 4.228 13.5969 -0.3941 29.7815
OVKATE GDSC1 6.2262 12.0895 1.8877 12.4931
EFO-27 GDSC1 6.6055 20.9188 -2.1588 28.1442
OVISE GDSC1 6.9485 25.8474 -4.3379 31.9203
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuP-T4 GDSC1 0.6139 6.4945 -0.472 47.6894
SUIT-2 GDSC1 0.9704 9.636 -1.4665 46.2159
Panc 04.03 GDSC1 1.1586 6.7564 -0.0032 43.1784
MZ-PC-1 GDSC1 1.4019 6.5389 0.3419 40.7185
Capan-1 GDSC1 1.7048 6.5082 0.6717 37.6917
Capan-2 GDSC1 1.8811 4.6062 1.5754 32.3637
Panc 03.27 GDSC1 2.2686 9.1348 0.0457 36.5503
KP-1N GDSC1 2.5017 4.9281 2.1423 25.1301
Panc 02.03 GDSC1 2.5736 18.4906 -4.2674 42.4771
SU.86.86 GDSC1 2.6333 3.9023 2.5744 21.4852
KP-4 GDSC1 3.0426 3.9295 3.01 16.1998
HuP-T3 GDSC1 3.0752 10.3649 0.2075 32.1747
MIA PaCa-2 GDSC1 3.117 3.8919 3.0946 15.2035
HPAC GDSC1 3.3316 11.4889 -0.117 32.227
BxPC-3 GDSC1 3.378 4.8038 3.1294 13.5004
QGP-1 GDSC1 3.3826 4.6613 3.1876 13.0617
Panc 08.13 GDSC1 3.4776 4.4924 3.3489 11.4145
PSN1 GDSC1 3.5861 4.2637 3.534 9.5375
CFPAC-1 GDSC1 3.5969 4.2343 3.5527 9.3495
KP-3 GDSC1 3.6108 8.035 1.8439 21.6153
PL4 GDSC1 3.7578 4.5989 3.6134 8.0391
PaTu 8988t GDSC1 3.7591 4.3202 3.7082 7.3694
PaTu 8902 GDSC1 3.8337 5.0654 3.4928 8.553
YAPC GDSC1 4.2548 6.0134 3.4196 7.3624
Hs 766T GDSC1 4.3466 5.3919 3.8073 3.9699
AsPC-1 GDSC1 4.6266 12.8065 0.3308 25.6411
SW1990 GDSC1 5.3222 7.133 3.6365 2.6794
DAN-G GDSC1 5.4802 7.188 3.7002 1.9741
Panc 10.05 GDSC1 5.8352 15.7618 -0.191 23.9858
HPAF-II GDSC1 6.3887 25.7472 -4.7208 33.6836
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 2.9518 4.088 2.8834 17.5678
NCI-H28 GDSC1 3.2062 4.3322 3.1015 14.6344
MSTO-211H GDSC1 3.3168 4.7416 3.0873 14.1245
IST-Mes1 GDSC1 3.5482 8.7607 1.4288 24.4059
NCI-H2052 GDSC1 3.554 4.4372 3.4497 10.2931
NCI-H2452 GDSC1 3.7144 4.4956 3.6045 8.3341
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1 2.9872 4.942 2.659 18.9177
VCaP GDSC1 3.0029 4.3887 2.8636 17.4065
PC-3 GDSC1 3.1206 4.4614 2.9703 16.0139
22Rv1 GDSC1 3.131 4.0041 3.0932 15.1285
LNCaP clone FGC GDSC1 3.5653 4.886 3.295 11.3357
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 7.946 20.5476 -1.0052 21.6884
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHL-1 GDSC1 -3.2742 3.2235 -3.6959 74.4968
A-431 GDSC1 -3.2165 3.107 -3.6079 74.5937
IGR-1 GDSC1 -1.2504 0.8761 -1.2565 68.7459
A-375 GDSC1 -0.229 3.025 -0.3601 56.0037
WM793 GDSC1 0.0881 1.1946 0.0879 52.9204
HT-144 GDSC1 0.1601 2.0223 0.1477 51.9866
SK-MEL-28 GDSC1 0.3981 1.6231 0.3971 49.0496
IPC-298 GDSC1 0.4592 2.0229 0.4529 48.297
WM1552C GDSC1 0.5481 2.3751 0.5305 47.2194
SH-4 GDSC1 1.0424 1.9082 1.0422 40.9958
WM278 GDSC1 1.0904 2.6555 1.0754 40.4773
A-388 GDSC1 1.2015 4.8029 0.7739 40.8335
IGR-37 GDSC1 1.2782 1.9504 1.2781 38.0474
HMV-II GDSC1 1.6095 2.6106 1.6072 33.9195
MZ-MEL-7 GDSC1 1.7397 5.255 1.2035 35.2434
COLO 792 GDSC1 1.8595 2.4222 1.8595 30.7805
G-mel GDSC1 1.9247 2.7327 1.9236 29.9725
SK-MEL-30 GDSC1 1.9341 3.9431 1.8089 30.6326
Hs 940.T GDSC1 2.06 10.2876 -0.706 39.5294
Hs 938.T GDSC1 2.1122 3.1076 2.1054 27.6645
G-361 GDSC1 2.2471 4.3271 2.0562 27.1658
RPMI-7951 GDSC1 2.3694 6.7092 1.2706 31.0874
LOX-IMVI GDSC1 2.5082 5.0009 2.1229 25.2224
SK-MEL-5 GDSC1 2.696 6.7143 1.5988 27.5052
SK-MEL-24 GDSC1 2.8072 3.5818 2.7977 18.9941
UACC-62 GDSC1 3.0226 3.4558 3.022 16.2452
IST-MEL1 GDSC1 3.4463 5.2253 3.0272 13.8985
LB2518-MEL GDSC1 3.4845 6.287 2.5769 17.071
Mel JuSo GDSC1 3.5254 4.5221 3.3907 10.8607
451Lu GDSC1 3.5387 5.0293 3.207 12.1142
SK-MEL-2 GDSC1 3.5408 9.6349 0.9894 26.7784
VMRC-MELG GDSC1 3.6507 4.3257 3.5884 8.7994
A2058 GDSC1 3.6729 5.7344 3.0219 12.8686
Mel Ho GDSC1 3.6835 9.7938 1.0373 25.9341
COLO 783 GDSC1 3.6987 4.3711 3.6277 8.2598
GAK GDSC1 3.7477 4.2547 3.7123 7.4075
MZ-MEL-2 GDSC1 3.7527 4.4131 3.6736 7.6419
COLO 829 GDSC1 3.7635 8.8759 1.5644 22.6945
CP66-MEL GDSC1 3.7759 4.2825 3.7363 7.0834
UACC-257 GDSC1 3.7777 4.2388 3.7484 6.9925
A101D GDSC1 3.7986 4.1277 3.7898 6.5978
WM115 GDSC1 3.801 4.1115 3.7941 6.5551
SK-MEL-1 GDSC1 3.811 4.1832 3.7952 6.4876
LB373-MEL-D GDSC1 3.8187 4.1838 3.8034 6.3884
M14 GDSC1 3.8225 4.3812 3.7597 6.6595
MMAc-SF GDSC1 3.8228 4.3667 3.7643 6.6264
MeWo GDSC1 3.8307 4.2636 3.8006 6.3356
WM35 GDSC1 3.8398 4.4808 3.7452 6.6655
SK-MEL-3 GDSC1 3.8423 4.1983 3.8263 6.0974
COLO 679 GDSC1 3.8448 4.4324 3.7674 6.4824
CP50-MEL-B GDSC1 3.8598 4.5405 3.7448 6.5617
COLO 800 GDSC1 4.074 9.4197 1.5636 21.4371
DJM-1 GDSC1 4.2196 13.8353 -0.5203 30.2284
WT2-iPS GDSC1 4.3926 5.3328 3.8741 3.2838
RVH-421 GDSC1 7.2574 21.3517 -1.8876 25.9178
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 3.3429 4.7998 3.0934 13.9425
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 GDSC1 0.7939 2.3277 0.7851 44.141
SK-UT-1 GDSC1 1.1172 3.5395 1.0029 40.6156
G-402 GDSC1 1.1677 2.6358 1.1559 39.4958
Rh30 GDSC1 1.2747 2.5695 1.268 38.1308
KYM-1 GDSC1 1.8097 2.9713 1.8006 31.4595
EW-8 GDSC1 2.6542 8.2284 0.8499 31.5764
MFH-ino GDSC1 2.683 3.7027 2.6566 20.6545
HT-1080 GDSC1 2.6869 3.5593 2.6741 20.5186
Rh18 GDSC1 2.7167 3.2942 2.7156 20.0721
SK-LMS-1 GDSC1 2.7899 4.0936 2.7063 19.6909
Rh41 GDSC1 2.7955 10.1138 0.0728 33.9107
GCT GDSC1 2.8799 4.8588 2.5747 20.0856
A-204 GDSC1 3.4651 5.9258 2.7284 16.0347
RKN GDSC1 3.4663 4.0217 3.4497 10.8012
Hs 633.T GDSC1 3.5725 7.9441 1.8538 21.7189
SW982 GDSC1 3.5794 4.2488 3.5303 9.6013
SW684 GDSC1 3.6323 4.2166 3.5952 8.8603
SW872 GDSC1 3.7874 4.4261 3.7072 7.2175
VA-ES-BJ GDSC1 3.8011 4.3019 3.7589 6.7861
RD GDSC1 3.8213 5.4003 3.3244 9.8892
MES-SA GDSC1 3.9666 4.7564 3.7666 5.8632
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-4 GDSC1 -2.2087 6.2668 -3.4172 64.6678
NCI-N87 GDSC1 -1.654 13.1775 -5.7154 57.0651
GCIY GDSC1 -0.9642 8.4346 -2.9242 56.9706
AGS GDSC1 -0.722 1.1209 -0.7261 62.7699
MKN1 GDSC1 0.6097 5.6707 -0.1639 47.4821
SNU-1 GDSC1 0.7616 2.7117 0.73 44.6287
HSC-39 GDSC1 1.1387 4.4732 0.8055 41.2089
KATO III GDSC1 1.5097 2.8757 1.4963 35.2354
MKN7 GDSC1 2.1261 3.5384 2.0852 27.7067
RERF-GC-1B GDSC1 2.3117 4.3148 2.13 26.3037
ECC10 GDSC1 2.3171 3.6458 2.2747 25.3293
TGBC11TKB GDSC1 2.4757 4.2002 2.339 23.9651
NUGC-3 GDSC1 2.8659 4.761 2.5945 20.024
Hs 746.T GDSC1 2.9626 3.6359 2.9554 17.0364
SCH GDSC1 3.4366 10.5349 0.45 29.6676
23132/87 GDSC1 3.5487 4.8333 3.2989 11.3919
MKN45 GDSC1 3.6836 4.4148 3.5979 8.5485
MKN28 GDSC1 3.7262 6.2271 2.8365 14.0461
RF-48 GDSC1 3.7922 4.519 3.6801 7.381
Fu97 GDSC1 3.7974 4.3697 3.7358 6.9639
HGC-27 GDSC1 3.8122 4.3158 3.7673 6.6665
SNU-16 GDSC1 4.5446 5.5389 3.8875 2.6989
IM95 GDSC1 5.1706 15.8628 -0.7574 27.9417
SNU-5 GDSC1 6.545 8.2162 3.7745 0.4981
OCUM-1 GDSC1 6.8279 8.7481 3.6917 0.6038
SNG-M GDSC1 -0.2227 3.194 -0.3816 55.8267
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMH-2 GDSC1 0.5683 3.9674 0.3165 47.3538
HTC-C3 GDSC1 1.2064 8.5957 -0.7553 44.1288
IHH-4 GDSC1 1.2361 4.0248 1.0305 39.5825
TT2609-C02 GDSC1 1.6837 4.194 1.4767 34.1998
CGTH-W-1 GDSC1 2.706 3.3082 2.7045 20.208
8505C GDSC1 2.7135 4.0424 2.6343 20.616
B-CPAP GDSC1 2.8061 4.046 2.734 19.4126
CAL-62 GDSC1 3.0342 4.1668 2.9557 16.6062
ML-1 [Human leukemia] GDSC1 3.2515 4.1931 3.1862 13.8037
K5 GDSC1 3.3012 4.6453 3.1055 14.0799
BHT-101 GDSC1 3.4441 4.1426 3.4063 11.2161
ASH-3 GDSC1 3.7742 4.257 3.7406 7.0648
8305C GDSC1 3.7889 4.2121 3.7661 6.8091
FTC-133 GDSC1 3.7902 4.2269 3.7646 6.8119
WRO GDSC1 3.8498 4.2514 3.8241 6.0674
TT GDSC1 3.8509 4.2714 3.8208 6.0834
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-15 GDSC1 -3.9749 15.6256 -9.1638 61.6307
SAT [Human HNSCC] GDSC1 -2.739 4.2766 -3.3716 70.1849
SCC-9 GDSC1 -1.5772 4.1301 -2.0646 64.9673
PCI-04B GDSC1 -0.6641 4.6037 -1.1989 58.3518
PCI-06A GDSC1 0.1999 4.6475 -0.2695 51.1536
CAL-27 GDSC1 0.2985 31.8571 -12.9273 50.0405
DOK GDSC1 0.5883 3.5151 0.4358 46.9873
BHY GDSC1 0.8177 7.6169 -0.7216 46.4776
NCI-H3118 GDSC1 1.2004 18.3287 -5.4271 47.2456
JHU-011 GDSC1 1.6821 3.5001 1.6167 33.3985
BB30-HNC GDSC1 1.7983 20.0405 -5.7283 45.6493
SCC-4 GDSC1 2.4262 5.6065 1.8014 27.755
KOSC-2 GDSC1 2.8861 4.155 2.7972 18.5245
SCC-25 GDSC1 3.3522 28.3637 -8.5163 43.45
SKN-3 GDSC1 3.3958 15.3355 -1.9745 36.7719
HO-1-N-1 GDSC1 3.4743 7.5895 1.9373 21.6108
BICR 22 GDSC1 3.5305 4.5415 3.3897 10.8402
PE/CA-PJ15 GDSC1 3.6021 48.0027 -18.1212 45.9639
CAL-33 GDSC1 3.7429 10.0025 0.9858 25.9464
Detroit 562 GDSC1 3.7774 4.4372 3.6926 7.3743
HSC-3 GDSC1 3.8212 4.2757 3.7873 6.4793
HSC-2 GDSC1 3.8338 4.2409 3.809 6.2618
BICR 78 GDSC1 3.8451 4.5186 3.7372 6.6934
HSC-4 GDSC1 3.846 4.2937 3.8099 6.1845
BICR 10 GDSC1 3.8861 4.3888 3.8265 5.8448
HO-1-u-1 GDSC1 3.9247 4.5976 3.7912 5.8899
LB771-HNC GDSC1 4.2178 5.2293 3.7788 4.6762
BB49-HNC GDSC1 4.4051 6.0111 3.5456 5.8283
PCI-15A GDSC1 4.5206 17.8633 -2.2839 33.8877
Ca9-22 GDSC1 5.0764 18.9331 -2.3648 32.5057
KON GDSC1 5.7747 7.3785 3.7677 1.1687
OSC-19 GDSC1 5.9157 20.0772 -2.2701 30.0999
BICR 31 GDSC1 5.938 19.2492 -1.8414 28.9725
SAS GDSC1 6.0903 8.8053 3.3259 3.3048
JHU-022 GDSC1 6.1478 17.8594 -0.9919 25.9536
OSC-20 GDSC1 6.2253 18.3207 -1.1614 26.2873
PCI-38 GDSC1 6.5911 8.0107 3.8645 0.2374
PCI-30 GDSC1 6.7886 23.75 -3.4208 30.5678
FaDu GDSC1 6.8463 8.2671 3.8672 0.1614
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 GDSC1 -0.1497 5.4141 -0.8947 53.8747
RT-4 GDSC1 2.3987 3.3943 2.3859 24.121
HT-1376 GDSC1 2.4702 11.7843 -1.0461 38.3942
UM-UC-3 GDSC1 2.5293 4.0929 2.4231 23.095
BFTC-905 GDSC1 2.5619 3.573 2.5423 22.1243
639V GDSC1 2.572 3.2615 2.5697 21.8886
647V GDSC1 2.7863 4.2778 2.6579 20.0348
T24 GDSC1 2.8724 3.8583 2.8383 18.3362
RT-112 GDSC1 3.081 3.6622 3.0762 15.5415
SW1710 GDSC1 3.1468 4.0196 3.1075 14.9407
HT-1197 GDSC1 3.2904 6.0354 2.5045 18.5066
SW780 GDSC1 3.4974 4.2817 3.4328 10.7288
TCCSUP GDSC1 3.5646 4.3207 3.4957 9.9185
J82 GDSC1 3.6384 4.3404 3.5709 8.9884
KU-19-19 GDSC1 3.6928 4.2608 3.651 8.1364
CAL-29 GDSC1 4.6223 17.0827 -1.8099 32.5282
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DSH1 GDSC1 -5.7312 1.9787 -6.1099 83.0094
OVMIU GDSC1 -1.8815 4.221 -2.4208 66.4562
BPH-1 GDSC1 -1.8349 4.2684 -2.3826 66.1277
Ca Ski GDSC1 -1.4682 2.1644 -1.565 68.1696
UWB1.289 GDSC1 -1.061 11.8597 -4.5198 55.6393
OMC-1 [Human cervical carcinoma] GDSC1 -0.2722 5.8101 -1.1646 54.5818
C-33 A GDSC1 0.5197 9.9567 -2.0646 48.9256
ME-180 GDSC1 0.9795 9.3258 -1.3153 46.0399
SW954 GDSC1 1.0621 7.0374 -0.2215 44.2265
NEC8 GDSC1 1.4133 2.4296 1.4116 36.3688
JEG-3 GDSC1 1.6051 2.4202 1.6046 33.9634
TC-YIK GDSC1 1.6416 2.5953 1.6398 33.5153
HEY GDSC1 1.7678 3.5031 1.7079 32.2986
KGN GDSC1 2.0808 3.1153 2.0728 28.0645
NCC-IT GDSC1 2.1298 3.478 2.0963 27.6129
OVCA420 GDSC1 2.2236 9.7707 -0.3014 37.7634
PA-1 GDSC1 2.3694 3.3627 2.3575 24.4812
CAL-39 GDSC1 2.4966 5.6472 1.859 27.0007
PEO1 GDSC1 2.6247 6.1537 1.777 26.8114
NT2-D1 GDSC1 2.7432 3.4786 2.7373 19.7714
HT-3 GDSC1 2.9771 8.6906 0.9358 29.5885
JAR GDSC1 2.9793 4.132 2.9039 17.2712
SiSo GDSC1 3.0708 4.1978 2.9883 16.1752
OVCA433 GDSC1 3.1797 4.4406 3.0411 15.1967
PWR-1E GDSC1 3.2532 4.4494 3.1184 14.2534
OV17R GDSC1 3.2575 7.3008 1.8734 23.0212
ACC-OV7 GDSC1 3.6749 6.1824 2.8096 14.4753
SW962 GDSC1 3.7271 5.2511 3.301 10.5012
SKN GDSC1 3.7479 4.8839 3.4862 9.0154
C-4-I GDSC1 3.7566 4.3745 3.6898 7.5087
HeLa GDSC1 3.8166 4.1481 3.8064 6.3815
HEC-1 GDSC1 3.8376 4.3381 3.7889 6.3745
LB831-BLC GDSC1 3.8378 4.4887 3.7402 6.7112
SKG-IIIa GDSC1 3.8457 4.4594 3.7591 6.5358
SiHa GDSC1 3.9166 4.3303 3.8772 5.3257
SW756 GDSC1 3.9723 4.5201 3.8725 5.0559
DoTc2 4510 GDSC1 4.4788 21.1177 -3.9456 36.8932
JHOS-3 GDSC1 4.599 16.6232 -1.5994 32.0829
MS751 GDSC1 6.8812 8.4888 3.8038 0.2726
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Dacomitinib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Oliceridine DM6MDCF Major Decreased metabolism of Dacomitinib caused by Oliceridine mediated inhibition of CYP450 enzyme. Acute pain [MG31] [8]
Pexidartinib DMS2J0Z Major Decreased metabolism of Dacomitinib caused by Pexidartinib mediated inhibition of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [9]
Deutetrabenazine DMUPFLI Major Decreased metabolism of Dacomitinib caused by Deutetrabenazine mediated inhibition of CYP450 enzyme. Dystonic disorder [8A02] [10]
Arry-162 DM1P6FR Moderate Decreased clearance of Dacomitinib due to the transporter inhibition by Arry-162. Melanoma [2C30] [11]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
FD&C blue no. 2 E00446 2723854 Colorant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 3350 E00652 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyvinyl alcohol E00666 Not Available Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
⏷ Show the Full List of 8 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Dacomitinib 15 mg tablet 15 mg Tablet Oral
Dacomitinib 30 mg tablet 30 mg Tablet Oral
Dacomitinib 45 mg tablet 45 mg Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2 Chen X, Jiang J, Giri N, Hu P: Phase 1 study to investigate the pharmacokinetic properties of dacomitinib in healthy adult Chinese subjects genotyped for CYP2D6. Xenobiotica. 2018 May;48(5):459-466. doi: 10.1080/00498254.2017.1342881. Epub 2017 Aug 18.
3 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
4 Wijnsma KL, Ter Heine R, Moes DJAR, Langemeijer S, Schols SEM, Volokhina EB, van den Heuvel LP, Wetzels JFM, van de Kar NCAJ, Bruggemann RJ: Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab. Clin Pharmacokinet. 2019 Jul;58(7):859-874. doi: 10.1007/s40262-019-00742-8.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797).
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7422).
7 Phase 1 study to investigate the pharmacokinetic properties of dacomitinib in healthy adult Chinese subjects genotyped for CYP2D6. Xenobiotica. 2018 May;48(5):459-466.
8 Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
9 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
10 Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
11 Cerner Multum, Inc. "Australian Product Information.".