Details of the Drug

General Information of Drug (ID: DMON4IL)

Drug Name
TG100-115
Synonyms TG-100115; TG-100-115; TG100115, TG100-115; 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol; 3-(2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl)phenol; 3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol
Indication
Disease Entry ICD 11 Status REF
Angioedema 4A00.15 Phase 1/2 [1]
Myocardial infarction BA41-BA43 Phase 1/2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 346.3
Logarithm of the Partition Coefficient (xlogp) 1.7
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C18H14N6O2
IUPAC Name
3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol
Canonical SMILES
C1=CC(=CC(=C1)O)C2=NC3=C(N=C(N=C3N=C2C4=CC(=CC=C4)O)N)N
InChI
InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
InChIKey
UJIAQDJKSXQLIT-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
10427712
ChEBI ID
CHEBI:94691
CAS Number
677297-51-7
UNII
7ACH1U1E2M
DrugBank ID
DB05552
TTD ID
D0C3ZR
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Angioedema
ICD Disease Classification 4A00.15
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PI3-kinase gamma (PIK3CG) DTT PIK3CG 1.98E-01 -0.05 -0.55
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 148 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 5.6655 6.6621 5.3822 3.6132
JK1 CTRP2 6.3221 8.8539 4.8639 4.4515
JM1 CTRP2 5.4265 6.2951 5.2881 4.6176
Ri-1 CTRP2 0.5575 5.4861 0.1991 37.5836
SUP-T1 CTRP2 2.1096 5.3637 1.9151 26.8776
CML-T1 CTRP2 2.8619 5.1829 2.7629 21.5396
EoL-1 CTRP2 2.9416 4.5545 2.9205 20.7421
KMS-34 CTRP2 3.334 4.6148 3.3229 18.0943
KHM-1B CTRP2 3.5359 6.7811 3.0754 18.363
MV4-11 CTRP2 3.6203 7.2058 3.0109 18.3631
GA-10 CTRP2 3.7 5.6565 3.5804 16.0305
SU-DHL-6 CTRP2 3.7802 6.6286 3.3924 16.4721
NB4 CTRP2 3.9734 5.0997 3.9556 13.8571
Pfeiffer CTRP2 4.048 7.1012 3.5076 15.2736
KMS-12-BM CTRP2 4.0783 6.5929 3.7274 14.3565
KMS-27 CTRP2 4.1565 5.618 4.0828 12.8296
JVM-2 CTRP2 4.2899 6.044 4.1298 12.2488
TALL-1 [Human adult T-ALL] CTRP2 4.3111 6.5777 3.9844 12.7214
SU-DHL-8 CTRP2 4.4635 8.7801 3.2083 15.356
HT CTRP2 4.4708 6.896 4.0376 12.0672
RS4;11 CTRP2 4.5362 7.4299 3.8876 12.4714
MOLT-16 CTRP2 4.5615 6.4673 4.2936 10.8402
JVM-3 CTRP2 4.5659 6.1995 4.3859 10.4857
THP-1 CTRP2 4.5848 6.5202 4.3002 10.7485
Karpas-422 CTRP2 4.6265 6.4802 4.3594 10.4058
KMS-26 CTRP2 4.6848 6.2426 4.5021 9.7056
DND-41 CTRP2 4.7596 6.4079 4.5285 9.3885
BV-173 CTRP2 4.7603 8.1554 3.7921 12.2756
SR CTRP2 4.7673 6.3885 4.5435 9.31
NU-DUL-1 CTRP2 4.864 6.735 4.5187 9.1302
RPMI-8402 CTRP2 4.8845 6.1215 4.7566 8.1775
PL21 CTRP2 4.9292 7.7984 4.1249 10.5147
MOLM-13 CTRP2 4.9574 6.3421 4.7653 7.9301
ST486 CTRP2 5.0462 8.0493 4.124 10.2304
Hs 611.T CTRP2 5.07 6.8589 4.6852 7.9233
Daudi CTRP2 5.0914 6.6225 4.8045 7.4026
RCH-ACV CTRP2 5.0947 8.7222 3.8502 11.2337
MOLT-3 CTRP2 5.0964 5.9013 5.0451 6.4926
KMS-28BM CTRP2 5.0967 7.7952 4.2927 9.4226
WSU-DLCL2 CTRP2 5.1032 6.1146 4.9973 6.6434
SU-DHL-1 CTRP2 5.1415 5.8358 5.1071 6.1331
Peer CTRP2 5.1507 6.7377 4.8202 7.1797
Mino CTRP2 5.1526 5.8447 5.1175 6.0611
Kasumi-1 CTRP2 5.1666 7.3194 4.5818 8.0823
ALL-SIL CTRP2 5.1683 6.453 4.9522 6.6225
P12-Ichikawa CTRP2 5.1741 6.7302 4.8478 7.0088
MM1.S CTRP2 5.1768 6.8968 4.78 7.2675
SU-DHL-10 CTRP2 5.1955 8.2155 4.1899 9.6045
EB1 CTRP2 5.2013 6.4632 4.9836 6.4105
OCI-AML-3 CTRP2 5.2062 6.0427 5.1301 5.8506
MC116 CTRP2 5.2159 6.7634 4.8775 6.7811
SU-DHL-4 CTRP2 5.2168 8.6285 4.0113 10.2888
JeKo-1 CTRP2 5.2244 6.6502 4.9337 6.5389
KE-37 CTRP2 5.2452 6.6484 4.9563 6.3946
BL-70 CTRP2 5.2591 5.8874 5.2246 5.3502
KE-97 CTRP2 5.3254 6.5526 5.0799 5.6968
MOLM-16 CTRP2 5.3281 7.5346 4.6421 7.4398
PF-382 CTRP2 5.3495 7.4661 4.6954 7.1714
SKM-1 CTRP2 5.3566 6.0368 5.2959 4.7944
OCI-AML-2 CTRP2 5.3577 6.2612 5.2263 5.0473
SUP-T11 CTRP2 5.3866 7.247 4.8344 6.5162
EJM CTRP2 5.4004 6.7094 5.0918 5.45
Ki-JK CTRP2 5.4233 6.4495 5.2249 4.8684
SUP-M2 CTRP2 5.457 6.0461 5.4029 4.1023
Granta-519 CTRP2 5.4574 8.954 4.0755 9.4822
AML-193 CTRP2 5.4669 6.587 5.2134 4.7959
NOMO-1 CTRP2 5.4864 9.4839 3.84 10.3979
OCI-Ly3 CTRP2 5.5293 6.7395 5.2102 4.6465
SUP-B15 CTRP2 5.5442 8.093 4.5783 7.2013
OCI-Ly10 CTRP2 5.5811 15.102 1.1239 20.6061
EHEB CTRP2 5.5883 8.7919 4.2742 8.3699
MOTN-1 CTRP2 5.6526 6.4302 5.4731 3.2832
RL CTRP2 5.6633 6.2728 5.5496 2.9562
REC-1 CTRP2 5.6659 9.2711 4.1057 8.9091
DEL CTRP2 5.6666 6.0453 5.6319 2.6383
SUP-HD1 CTRP2 5.6761 7.0254 5.221 4.2441
F-36P CTRP2 5.6892 7.4436 5.0305 5.0007
Ci-1 CTRP2 5.6948 6.4529 5.5064 3.0413
HEL 92.1.7 CTRP2 5.6998 8.7627 3.6992 4.8297
SEM CTRP2 5.7075 6.9564 5.2843 3.9108
MOLP-8 CTRP2 5.715 6.476 5.5167 2.9482
SET-2 CTRP2 5.7358 6.3837 5.5789 2.6472
L-363 CTRP2 5.7685 6.6416 5.4932 2.9107
NU-DHL-1 CTRP2 5.7767 7.5472 5.0597 4.6867
RPMI-6666 CTRP2 5.7821 6.5068 5.5699 2.5658
NALM-6 CTRP2 5.7855 13.3562 2.1706 16.4745
JURL-MK1 CTRP2 5.8025 6.9679 5.3683 3.346
CA46 CTRP2 5.8231 6.7195 5.5084 2.72
M-07e CTRP2 5.8258 6.7714 5.4859 2.8067
P31/FUJ CTRP2 5.8325 7.4535 5.1563 4.1634
OCI-Ly19 CTRP2 5.8345 8.8433 4.4664 7.0494
A3/Kawakami CTRP2 5.8366 6.4222 5.6632 2.0544
Namalwa CTRP2 5.8428 6.6624 5.5546 2.484
KMS-18 CTRP2 5.8648 7.2626 5.2799 3.5777
DB CTRP2 5.8659 6.831 5.4939 2.6831
Ku812 CTRP2 5.8965 9.8898 3.9971 8.8917
HEL CTRP2 5.8992 6.8963 5.4921 2.6177
Kasumi-2 CTRP2 5.9654 8.2284 4.8858 5.0245
TF-1 CTRP2 6.0058 6.7054 5.6812 1.603
SIG-M5 CTRP2 6.0189 6.718 5.6861 1.556
U-937 CTRP2 6.0227 7.0544 5.5212 2.2415
LAMA-84 CTRP2 6.0358 8.0495 5.0347 4.2608
MOLT-13 CTRP2 6.0607 7.3024 5.4289 2.5558
OPM-2 CTRP2 6.0665 7.0911 5.5393 2.0808
MOLP-2 CTRP2 6.0834 9.8246 4.1867 7.7319
NCO2 CTRP2 6.1007 7.7449 5.2406 3.2715
HD-MY-Z CTRP2 6.1014 7.1621 5.5323 2.0447
Mono-Mac-6 CTRP2 6.1107 9.8441 4.1995 7.6263
Jurkat CTRP2 6.1302 8.0913 5.0915 3.8426
A4/Fukuda CTRP2 6.1541 8.2735 4.2341 1.893
Karpas-620 CTRP2 6.2032 7.4271 5.4805 2.0809
K-562 CTRP2 6.2447 7.2749 5.587 1.5687
MOLM-6 CTRP2 6.2637 8.2696 5.1089 3.529
KMS-20 CTRP2 6.2961 8.7413 4.8995 4.3478
HL-60 CTRP2 6.3476 7.8359 5.3871 2.2298
EM-2 CTRP2 6.3891 8.362 5.1588 3.1078
NCI-H929 CTRP2 6.394 11.4387 3.6328 9.4629
L-1236 CTRP2 6.437 8.57 5.092 3.3065
U266B1 CTRP2 6.4725 9.3145 4.751 4.6642
GDM-1 CTRP2 6.4789 9.4317 4.6978 4.875
MHH-CALL-3 CTRP2 6.5126 9.1964 4.8396 4.2293
Mono-Mac-1 CTRP2 6.5261 8.7414 5.0732 3.241
KCL-22 CTRP2 6.5611 8.5462 5.1935 2.6939
LP-1 CTRP2 6.6391 8.9323 5.061 3.117
MHH-CALL-4 CTRP2 6.7012 23.245 -2.0149 26.7287
L-540 CTRP2 6.721 8.3972 5.3728 1.7531
CMK CTRP2 6.7983 8.2674 5.4806 1.2495
P3HR-1 CTRP2 6.8862 12.6058 3.4361 9.4029
HPB-ALL CTRP2 6.8968 10.5343 4.4641 5.1662
KMS-21-BM CTRP2 7.0702 9.2043 5.2154 1.9313
OCI-AML-5 CTRP2 7.1019 8.3675 5.601 0.5677
Karpas-299 CTRP2 7.1743 12.7024 3.6037 8.2462
KMM-1 CTRP2 7.1951 10.6385 4.6211 4.092
KM-H2 CTRP2 7.318 10.9379 4.5603 4.1652
Reh CTRP2 7.387 11.0124 4.5704 4.0324
AMO1 CTRP2 7.4091 9.0006 5.4893 0.6827
Toledo CTRP2 7.5753 15.2098 2.6665 11.3058
OCI-M1 CTRP2 7.6517 8.7355 5.6931 0.124
HDLM-2 CTRP2 7.6568 12.5692 4.0082 5.8927
Raji CTRP2 7.6847 9.1294 5.5621 0.3473
KMS-11 CTRP2 7.7236 13.6247 3.546 7.6332
ME1 CTRP2 7.7508 9.6203 5.3992 0.7159
JJN-3 CTRP2 7.8949 9.5203 5.5019 0.3882
KO52 CTRP2 8.0337 9.0006 5.737 0.0317
L-428 CTRP2 8.0392 9.6344 5.5183 0.3004
KYO-1 CTRP2 8.0847 9.406 5.6175 0.1325
RPMI-8226 CTRP2 8.2706 10.0224 5.4677 0.316
HuT 78 CTRP2 8.5858 10.5232 5.4089 0.3201
⏷ Show the Full List of 148 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 6.3846 11.7918 3.4491 10.238
TE15 CTRP2 8.0458 9.5968 5.5347 0.2683
KYSE-70 CTRP2 4.4682 7.1995 3.9132 12.5541
KYSE-180 CTRP2 5.2224 6.5988 4.9525 6.4714
TE-9 CTRP2 5.3231 7.2779 4.7572 6.9853
TE-5 CTRP2 5.5213 6.4674 5.3207 4.2303
TE-10 CTRP2 6.0257 8.8092 4.6464 5.9123
OE21 CTRP2 6.1513 7.4676 5.4198 2.4262
TE-4 CTRP2 6.1816 17.4274 0.4668 21.4577
OE33 CTRP2 6.2392 7.7904 5.3279 2.6559
TE-14 CTRP2 6.2431 8.0792 5.1875 3.2364
EC-GI-10 CTRP2 6.3513 7.8266 5.3943 2.194
KYSE-140 CTRP2 6.5221 13.043 2.9348 12.0708
KYSE-520 CTRP2 6.5472 9.0672 4.9289 3.8032
TE-1 CTRP2 6.9117 10.1153 4.6786 4.2673
KYSE-510 CTRP2 7.2489 10.8371 4.5623 4.252
KYSE-30 CTRP2 7.4015 9.601 5.2292 1.5295
TE-11 CTRP2 7.4723 9.1315 4.506 0.2121
KYSE-450 CTRP2 7.5903 9.0311 5.5596 0.3951
COLO 680N CTRP2 7.643 11.5046 4.5038 3.9611
KYSE-410 CTRP2 7.7546 12.7801 3.9731 5.8958
OE19 CTRP2 7.8606 9.1653 5.619 0.1815
KYSE-150 CTRP2 8.163 9.5764 5.5867 0.1562
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 6.7137 8.1947 5.4626 1.4153
HuP-T4 CTRP2 5.1735 8.293 4.1317 9.8945
L3.3 CTRP2 5.7626 6.4979 5.5547 2.6757
BxPC-3 CTRP2 6.1316 8.1147 5.081 3.8844
MIA PaCa-2 CTRP2 6.1556 6.9443 5.6835 1.3156
PaTu 8988s CTRP2 6.1829 8.0851 5.1371 3.5547
Panc 05.04 CTRP2 6.1833 10.6614 3.8506 8.9486
SW1990 CTRP2 6.364 8.0102 5.3135 2.5079
PSN1 CTRP2 6.408 13.0222 2.8537 12.605
SNU-213 CTRP2 6.504 15.6864 1.6008 17.1307
KP-4 CTRP2 6.5747 8.8224 5.0687 3.1839
HuP-T3 CTRP2 6.5768 8.428 5.2618 2.3929
PK-45H CTRP2 6.6892 9.5484 4.7964 4.1247
Capan-1 CTRP2 6.7159 13.1154 3.0517 11.2527
KP-2 CTRP2 6.7631 7.9308 5.6114 0.8144
SU.86.86 CTRP2 6.82 17.6155 0.8919 18.9154
QGP-1 CTRP2 6.8369 8.3086 5.4847 1.1924
SUIT-2 CTRP2 7.0776 9.2172 5.214 1.928
Panc 08.13 CTRP2 7.0818 10.4858 4.6175 4.2662
Panc 02.03 CTRP2 7.1299 9.2408 5.2346 1.7917
KP-3 CTRP2 7.2132 11.0642 4.4291 4.8366
PaTu 8988t CTRP2 7.231 10.8669 4.536 4.3822
PaTu 8902 CTRP2 7.3689 8.707 5.5886 0.4367
Panc 03.27 CTRP2 7.4199 8.8928 5.538 0.5397
TCC-Pan2 CTRP2 7.4345 12.6401 3.8209 6.9641
HPAF-II CTRP2 7.5058 12.6985 3.8425 7.8004
PK-59 CTRP2 7.5138 11.921 4.2221 5.2413
CFPAC-1 CTRP2 7.5531 9.5458 5.3337 1.0484
Capan-2 CTRP2 7.6864 10.689 4.9057 2.3938
DAN-G CTRP2 7.6958 9.2227 5.5312 0.4112
HPAC CTRP2 7.7058 9.8045 5.3019 1.0297
Hs 766T CTRP2 7.786 9.4266 5.4914 0.4608
YAPC CTRP2 7.796 10.8189 4.9106 2.2621
Panc 04.03 CTRP2 8.585 10.2394 5.5097 0.1689
AsPC-1 CTRP2 9.0631 10.9862 5.4239 0.1824
SNU-410 CTRP2 9.5652 30.7989 -3.5351 25.1324
Panc 10.05 CTRP2 12.9595 25.5226 1.2861 9.1319
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 8.4181 10.9252 5.1843 0.8947
WM115 CTRP2 4.8959 6.6809 4.5739 8.8296
WM983B CTRP2 5.4472 9.4723 3.8105 10.6053
Mel Ho CTRP2 5.49 8.347 4.4038 8.0464
Hs 852.T CTRP2 5.6283 9.6327 3.8927 9.877
A-375 CTRP2 5.6842 9.2833 4.1158 8.8284
WM88 CTRP2 5.7257 6.7026 5.4228 3.3008
WM1799 CTRP2 5.7847 8.8107 4.4393 7.2652
COLO 800 CTRP2 5.7985 7.2044 5.2486 3.8521
LOX-IMVI CTRP2 5.9133 6.9466 5.4799 2.6387
COLO 792 CTRP2 5.9189 7.9523 4.9839 4.7059
MeWo CTRP2 5.9241 8.4907 4.7196 5.8051
WM266-4 CTRP2 5.9862 6.9811 5.5267 2.2909
HMCB CTRP2 6.0371 6.7105 5.7052 1.44
Mel JuSo CTRP2 6.0521 7.559 5.2935 3.1412
SK-MEL-24 CTRP2 6.0618 7.3545 5.4038 2.6595
A2058 CTRP2 6.0819 7.0883 5.5534 1.9926
SK-MEL-30 CTRP2 6.1072 8.8922 4.6725 5.6467
SK-MEL-5 CTRP2 6.1514 7.2185 5.544 1.9057
WT2-iPS CTRP2 6.1813 7.0609 5.6452 1.4315
IGR-1 CTRP2 6.183 15.1504 1.6064 17.7322
UACC-257 CTRP2 6.2057 7.6557 5.3689 2.5429
UACC-62 CTRP2 6.2127 7.703 5.3508 2.6065
K029AX CTRP2 6.2818 7.5653 5.4716 1.9865
Hs 944.T CTRP2 6.359 9.2379 4.7017 5.0649
SK-MEL-1 CTRP2 6.5192 8.4065 5.2319 2.6005
SK-MEL-3 CTRP2 6.5511 8.3729 5.2706 2.3948
SK-MEL-28 CTRP2 6.5719 9.4128 4.7771 4.3913
RPMI-7951 CTRP2 6.5858 9.7204 4.6358 4.9543
COLO 829 CTRP2 6.5876 8.1321 5.4111 1.7779
A101D CTRP2 6.6042 8.1804 5.3991 1.803
IPC-298 CTRP2 6.6295 7.9085 5.5431 1.2095
Hs 936.T CTRP2 6.6457 9.377 4.8487 3.9774
G-361 CTRP2 6.6526 10.0051 4.5452 5.2202
COLO 741 CTRP2 6.6686 12.5675 3.2873 10.386
Hs 294T CTRP2 6.6751 8.0007 5.5286 1.2106
HT-144 CTRP2 6.6944 8.305 5.399 1.6849
IGR-39 CTRP2 6.6965 8.5515 5.2838 2.136
Hs 895.T CTRP2 6.6996 10.3023 4.4337 5.6051
RVH-421 CTRP2 6.8098 8.5623 5.3518 1.7232
Hs 940.T CTRP2 6.8208 11.5789 3.8946 7.6343
WM793 CTRP2 7.0436 11.1221 4.2824 5.6838
SK-MEL-31 CTRP2 7.1756 8.5814 5.5485 0.6718
MDA-MB-435S CTRP2 7.2007 11.3284 4.2929 5.4047
Malme-3M CTRP2 7.2186 11.837 4.0587 6.328
SK-MEL-2 CTRP2 7.2728 8.548 5.6082 0.4397
CJM [Human melanoma] CTRP2 7.283 8.3251 5.6985 0.2239
IGR-37 CTRP2 7.389 8.7848 5.5669 0.4812
Hs 934.T CTRP2 7.5012 14.1919 3.1118 9.693
Hs 688(A).T CTRP2 7.6165 15.967 2.3245 12.5304
Hs 839.T CTRP2 8.0319 14.6908 3.2446 8.3668
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MHH-NB-11 CTRP2 5.3887 6.7171 5.0764 5.5414
SK-N-BE(2) CTRP2 5.4774 7.1843 4.9531 5.8132
NB1 CTRP2 5.6343 6.5915 5.383 3.6884
Kelly CTRP2 5.7268 6.9732 5.2946 3.8234
CHP-212 CTRP2 5.792 7.0292 5.3286 3.5343
SK-N-FI CTRP2 6.1853 7.8256 5.2683 3
CHP-126 CTRP2 6.2948 8.3789 5.0787 3.6009
SK-N-AS CTRP2 6.3201 7.7362 5.4159 2.1551
KP-N-SI9s CTRP2 6.3341 9.1414 4.7303 4.9893
NH-6 CTRP2 6.4242 8.802 4.9679 3.8425
SK-N-SH CTRP2 6.4913 10.5315 4.1616 7.0899
SK-N-DZ CTRP2 7.3022 8.6959 5.5625 0.545
KP-N-YN CTRP2 7.928 10.3295 5.1934 1.1957
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 5.1766 7.3381 4.5833 8.0511
SNU-1079 CTRP2 5.4277 8.6293 3.5605 5.9302
HuH-28 CTRP2 5.9083 8.6776 4.6127 6.2857
SNU-1196 CTRP2 6.4833 8.0466 5.3813 2.0455
HuCC-T1 CTRP2 6.6715 9.5759 4.7701 4.2607
SNU-869 CTRP2 7.0116 9.5673 5.0091 2.8005
SNU-308 CTRP2 7.0734 9.849 4.9161 3.0852
SNU-245 CTRP2 7.6195 10.4024 4.9959 2.1378
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC CTRP2 5.2426 5.8787 5.2084 5.4587
MHH-ES-1 CTRP2 5.3373 6.7489 5.0096 5.9402
A-673 CTRP2 5.3501 6.2144 5.2343 5.0393
TC71 CTRP2 5.4121 5.95 5.3776 4.3314
G-292 clone A141B1 CTRP2 5.4438 8.9152 4.0821 9.4844
SK-ES-1 CTRP2 5.925 7.4055 5.262 3.5268
U2OS CTRP2 6.0717 8.7507 4.7139 6.4001
CAL-78 CTRP2 6.3134 15.463 1.5573 17.6495
HOS CTRP2 6.3468 7.44 5.5797 1.4411
Hs 822.T CTRP2 6.4874 10.021 4.4122 6.0512
MG-63 CTRP2 6.6198 10.319 4.3656 6.0197
Hs 888.T CTRP2 7.0054 8.9203 5.3064 1.6646
SaOS-2 CTRP2 7.0476 10.8728 4.4065 5.1715
SW1353 CTRP2 7.4106 16.9068 1.7055 15.1211
SJSA-1 CTRP2 7.5808 23.8904 -1.6327 24.3692
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 68 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-BR-3 CTRP2 3.7082 6.0893 3.4824 16.3553
DU4475 CTRP2 3.7379 5.365 3.6749 15.5803
ZR-75-1 CTRP2 4.5101 9.1743 3.0699 15.793
MDA-MB-361 CTRP2 4.8341 8.9806 3.4765 13.3736
MDA-MB-453 CTRP2 4.8461 7.2733 4.2757 10.1258
MDA-MB-157 CTRP2 4.9097 9.2745 3.4079 13.4736
HCC1954 CTRP2 4.9973 7.0619 4.5232 10.1117
MDA-MB-468 CTRP2 5.1022 6.8115 4.7387 7.6282
EFM-192A CTRP2 5.1269 7.4021 4.5043 8.4936
Hs 578T CTRP2 5.2875 7.2663 4.7272 7.1947
HCC1143 CTRP2 5.3017 8.9195 3.9491 10.352
HCC1419 CTRP2 5.3659 9.2433 3.8495 10.6215
CAL-85-1 CTRP2 5.3708 7.889 4.5144 7.861
HCC38 CTRP2 5.4522 8.5518 4.2685 8.692
HCC1806 CTRP2 5.6087 6.5903 5.3577 3.8546
HCC202 CTRP2 5.6905 9.3879 4.0692 9.0098
HCC2218 CTRP2 5.8919 9.7455 4.0653 8.6154
BT-549 CTRP2 6.1721 8.898 4.7226 5.3146
CAL-51 CTRP2 6.1771 7.821 5.2641 3.0327
MCF-7 CTRP2 6.1933 10.7793 3.7999 9.1413
T-47D CTRP2 6.279 10.9876 3.7654 9.1245
CAMA-1 CTRP2 6.3595 9.9955 4.3249 6.6409
BT-474 CTRP2 6.3637 8.8581 4.894 4.2533
KPL-1 CTRP2 6.5695 8.2742 5.3309 2.1242
CAL-120 CTRP2 6.5747 8.8761 5.0425 3.2917
ZR-75-30 CTRP2 6.5817 9.3523 4.8141 4.2221
HMC-1-8 CTRP2 6.6598 8.3813 5.3404 1.9606
HCC1428 CTRP2 6.7475 8.3167 5.4271 1.5103
HCC1500 CTRP2 6.9006 8.4064 5.4776 1.1509
HCC1395 CTRP2 6.9277 10.0482 4.7223 4.0662
MDA-MB-231 CTRP2 6.9334 10.5403 4.4874 5.0145
BT-20 CTRP2 6.9851 8.4913 5.4874 1.0319
HCC1937 CTRP2 7.1167 12.0994 3.8574 7.3058
HDQ-P1 CTRP2 7.1827 9.2764 5.2496 1.6793
JIMT-1 CTRP2 8.4143 9.6859 5.6385 0.0637
BT 239 CTRP2 4.9593 7.7912 4.1582 10.3056
BT 139 CTRP2 5.582 10.1403 3.5994 11.1937
BT 231 CTRP2 5.6281 8.8319 4.2901 8.2183
BT164 CTRP2 5.6643 7.878 4.7943 6.0374
BT 271 CTRP2 5.7121 8.9374 4.3124 7.9476
BT 112 CTRP2 5.7265 7.7448 4.9167 5.3917
BT 248 CTRP2 5.774 8.11 4.7784 5.8674
BT 145 CTRP2 6.0486 7.7483 5.1959 3.5584
BT 416 CTRP2 6.0779 8.9876 4.6006 6.0042
BT 504 CTRP2 6.2813 10.3464 4.0875 7.7765
BT 286 CTRP2 6.3704 7.8562 5.3937 2.1663
BT 179 CTRP2 6.4787 8.8138 5.0028 3.608
BT 422 CTRP2 6.5111 9.112 4.88 4.064
BT 224 CTRP2 6.5303 8.5306 5.1793 2.799
BT 440 CTRP2 6.5543 9.5908 4.6762 4.8386
BT 228 CTRP2 6.5769 11.5182 3.7376 8.701
BT 320 CTRP2 6.6187 9.1517 4.9395 3.6463
BT 482 CTRP2 6.6762 8.9211 5.0925 2.9337
BT 428 CTRP2 6.7149 8.6045 5.2708 2.1626
BT 330 CTRP2 6.7983 10.1445 4.5836 4.8289
BT 444 CTRP2 6.8216 11.0049 4.1783 6.4624
BT 245 CTRP2 6.8285 9.4601 4.9376 3.3389
BT147 CTRP2 6.8289 11.808 3.7874 8.062
BT 159 CTRP2 6.8654 10.5592 4.4293 5.3581
BT 216 CTRP2 6.8792 9.6202 4.8953 3.4367
BT 172 CTRP2 7.0415 9.8741 4.8832 3.2587
BT 340 CTRP2 7.278 11.4641 4.281 5.3397
BT 333 CTRP2 7.4205 11.5264 4.348 4.8691
BT 328 CTRP2 7.6019 13.234 3.6503 7.3983
BT 359 CTRP2 7.7592 21.2177 -0.1648 20.3945
BT 232 CTRP2 7.7755 15.4449 2.6971 10.8686
BT 187 CTRP2 8.1945 12.9972 4.1547 4.6202
BT 131 CTRP2 9.0303 26.68 -1.903 22.6547
⏷ Show the Full List of 68 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 6.6259 8.5797 5.2225 2.4803
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
42-MG-BA CTRP2 5.6147 8.5243 4.4304 7.6618
SF539 CTRP2 5.6222 7.9699 4.7106 6.4785
SF268 CTRP2 5.6256 9.9421 3.7364 10.5335
GB-1 CTRP2 5.668 8.4077 4.536 7.1061
SNU-201 CTRP2 6.0182 9.9337 3.3561 5.8072
Daoy CTRP2 6.0275 15.6154 1.2448 19.2859
Becker CTRP2 6.1237 8.2572 5.0034 4.2252
YKG-1 CTRP2 6.1325 8.4564 4.911 4.5966
DBTRG-05MG CTRP2 6.1747 10.7308 3.8089 9.1387
GMS-10 CTRP2 6.252 9.6364 4.4183 6.4443
KNS-42 CTRP2 6.2644 7.9191 5.2835 2.7983
DK-MG CTRP2 6.2713 8.4723 5.014 3.9125
SW1783 CTRP2 6.2973 9.3332 4.6057 5.5765
YH-13 CTRP2 6.3667 9.3835 4.6352 5.3297
GaMG CTRP2 6.3964 11.4075 3.6503 9.3861
U-118MG CTRP2 6.401 8.642 5.0294 3.6255
M059K CTRP2 6.4728 8.1154 5.3405 2.2269
SNU-466 CTRP2 6.4738 8.9642 4.9251 3.9381
Hs 683 CTRP2 6.4879 8.8135 5.0099 3.5637
SNU-738 CTRP2 6.5028 7.8106 5.5079 1.5087
ONS-76 CTRP2 6.5861 8.5133 5.227 2.5204
D283 Med CTRP2 6.6026 8.0824 5.4446 1.6254
LN-18 CTRP2 6.6603 7.9493 5.5432 1.1728
CCF-STTG1 CTRP2 6.7072 8.9346 5.1075 2.8279
KG-1-C CTRP2 6.7346 9.2757 4.9615 3.3796
SNU-1105 CTRP2 6.7702 12.5855 3.3573 9.9232
SNU-489 CTRP2 6.7707 9.4901 4.8828 3.6461
LN-229 CTRP2 6.8009 8.9033 5.1856 2.3841
GOS-3 CTRP2 6.8026 8.8175 5.2274 2.2169
SF126 CTRP2 6.8441 10.1427 4.6174 4.6193
U-87MG ATCC CTRP2 6.9429 10.5983 4.4659 5.0879
SNB-75 CTRP2 6.945 12.5651 3.5008 9.0404
SW1088 CTRP2 6.9698 12.2091 3.6952 8.206
SNU-626 CTRP2 6.9863 8.5824 5.4478 1.17
KNS-60 CTRP2 7.1228 16.8941 1.49 16.3764
NMC-G1 CTRP2 7.1506 9.5927 5.0855 2.3291
SF295 CTRP2 7.2388 8.6275 5.5603 0.5925
A-172 CTRP2 7.3371 12.8855 3.6322 7.8737
8-MG-BA CTRP2 7.5743 9.0731 5.5363 0.4585
KALS-1 CTRP2 7.6418 16.7245 1.9701 13.7874
TM-31 CTRP2 7.885 12.2365 4.3148 4.3879
T98G CTRP2 7.8958 15.2956 2.8562 10.0723
U-251MG CTRP2 8.4692 16.4951 2.6757 9.9025
AM-38 CTRP2 8.512 10.038 5.5531 0.1306
KNS-81 CTRP2 10.2821 28.4312 -1.8439 20.7101
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA CTRP2 5.3315 7.4129 4.7026 7.1859
JHUEM-2 CTRP2 5.4804 6.976 5.0532 5.4003
JHUEM-1 CTRP2 5.6246 6.6803 5.3329 3.9135
JHUEM-3 CTRP2 5.7058 8.357 4.595 6.779
JHUEM-7 CTRP2 5.7812 6.7419 5.4577 3.0259
KLE CTRP2 5.8036 10.5781 3.5739 10.8426
ESS-1 CTRP2 5.9494 6.8863 5.5419 2.303
RL95-2 CTRP2 6.1315 8.2854 4.9956 4.2431
EN CTRP2 6.176 7.1389 5.6026 1.6178
HEC-59 CTRP2 6.1891 7.7757 5.2962 2.8766
HEC-108 CTRP2 6.2397 7.3205 5.5609 1.685
HEC-1-A CTRP2 6.2427 9.4003 4.5287 5.9981
MFE-296 CTRP2 6.4018 8.0133 5.3396 2.3397
HEC-251 CTRP2 6.572 8.7905 5.0823 3.1323
HEC-6 CTRP2 6.7433 8.4926 5.3422 1.8438
HEC-151 CTRP2 6.9707 8.5778 5.441 1.2098
HEC-1-B CTRP2 6.9767 8.8678 5.3132 1.6717
EFE-184 CTRP2 7.4645 11.4409 4.4181 4.5302
HEC-265 CTRP2 7.8088 9.1098 5.6191 0.1955
MFE-319 CTRP2 8.2005 9.7107 5.5532 0.1946
HEC-50B CTRP2 10.9221 22.6716 1.3592 11.1753
Ishikawa (Heraklio) 02 ER- CTRP2 6.6204 9.1171 4.9576 3.5693
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMRC-1 CTRP2 6.2369 8.1522 5.1464 3.4191
OS-RC-2 CTRP2 6.4358 10.6695 4.0493 7.6561
KMRC-3 CTRP2 6.4742 9.9349 4.4447 5.9384
CAL-54 CTRP2 6.4896 7.9071 5.4529 1.7471
BFTC-909 CTRP2 6.577 10.3591 4.3133 6.3098
KMRC-20 CTRP2 6.6523 10.3406 3.5862 3.8901
VMRC-RCZ CTRP2 6.6922 8.4549 5.3269 1.9708
TUHR10TKB CTRP2 6.7251 8.1047 5.5111 1.2185
ACHN CTRP2 6.7438 8.4546 5.3604 1.7723
KMRC-2 CTRP2 6.8041 9.486 4.9083 3.4932
Caki-2 CTRP2 6.8785 8.3594 5.4859 1.1436
786-O CTRP2 6.884 8.5488 4.4865 0.4571
TUHR4TKB CTRP2 6.9981 8.8407 5.3384 1.5541
A-498 CTRP2 7.0025 8.7725 5.3719 1.4262
TUHR14TKB CTRP2 7.2282 10.7194 4.6047 4.1116
769-P CTRP2 7.3532 11.1238 4.4952 5.0533
RCC10RGB CTRP2 7.6009 9.9521 5.1845 1.4962
VMRC-RCW CTRP2 7.7896 10.2984 5.1354 1.4931
Caki-1 CTRP2 7.8995 11.5239 4.6528 3.0904
SNU-1272 CTRP2 8.2342 9.5267 5.6296 0.0936
UO-31 CTRP2 8.2835 20.8463 0.4166 17.8493
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H716 CTRP2 4.8684 8.472 3.7511 12.176
COLO201 CTRP2 5.2601 8.2482 4.236 9.2637
MDST8 CTRP2 5.6688 6.9718 5.2397 4.1848
LoVo CTRP2 5.8855 7.4932 5.1836 3.937
HT-55 CTRP2 5.9087 7.7939 5.0541 4.4322
SNU-C1 CTRP2 6.0115 7.0266 5.5257 2.2447
SW48 CTRP2 6.0121 8.3101 4.8845 4.9379
CCK-81 CTRP2 6.0457 7.3241 5.4056 2.6824
SW620 CTRP2 6.0686 7.2628 5.4553 2.4299
LS123 CTRP2 6.0846 7.1059 5.5467 2.0155
SK-CO-1 CTRP2 6.1127 7.3379 5.4537 2.3543
SW1417 CTRP2 6.2392 8.5905 4.9298 4.3225
SNU-C5 CTRP2 6.2658 8.6903 4.9011 4.395
C2BBe1 CTRP2 6.2839 8.6598 4.9305 4.2398
NCI-H508 CTRP2 6.333 8.5034 5.0463 3.6702
COLO205 CTRP2 6.3926 7.7618 5.4558 1.8775
GP2d CTRP2 6.4074 8.1706 5.2666 2.6319
HT115 CTRP2 6.4193 8.8718 4.9297 4.0097
SNU-503 CTRP2 6.4298 8.7367 5.0044 3.6818
COLO 678 CTRP2 6.5964 8.877 5.0576 3.196
LS1034 CTRP2 6.6024 8.5751 5.2085 2.5714
RCM-1 [Human ESC] CTRP2 6.7157 8.0456 5.5325 1.1494
T84 CTRP2 6.7566 9.2063 5.0104 3.1489
SNU-175 CTRP2 6.9043 8.7428 5.3267 1.705
LS180 CTRP2 6.949 10.6827 4.4291 5.2292
SNU-1033 CTRP2 6.9933 11.6367 3.9943 6.9422
SNU-C2A CTRP2 7.0419 11.2242 4.2315 6.8038
SNU-407 CTRP2 7.2032 10.9005 4.501 4.5616
SNU-61 CTRP2 7.3355 8.9591 5.4705 0.7908
NCI-H747 CTRP2 7.533 10.8538 4.738 3.1952
HCT 15 CTRP2 7.5623 8.9428 4.6032 0.0808
SNU-C4 CTRP2 7.6195 8.7396 5.6796 0.1511
CL-11 CTRP2 7.6497 13.5116 3.5493 7.7298
LS411N CTRP2 7.6603 8.8899 5.6411 0.2021
HCT 8 CTRP2 7.7078 8.9883 5.6239 0.2174
HCC-56 CTRP2 7.7144 8.7111 5.7243 0.0752
DLD-1 CTRP2 7.718 8.6646 5.7414 0.0584
KM12 CTRP2 7.7619 9.8151 5.3252 0.9193
HT-29 CTRP2 7.7935 9.1549 5.5968 0.2383
OUMS-23 CTRP2 7.7942 8.8983 5.6884 0.1013
HCT 116 CTRP2 7.8937 9.4568 5.5253 0.3397
CW-2 CTRP2 7.9106 9.9424 5.3439 0.7688
LS513 CTRP2 7.9532 9.3745 5.5793 0.2196
SW948 CTRP2 8.1997 9.4761 5.6347 0.0935
COLO 320 CTRP2 8.452 19.6958 1.1064 15.4305
RKO CTRP2 9.5657 20.5039 1.497 12.4991
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 CTRP2 4.7251 8.0026 3.827 12.2235
SNU-182 CTRP2 5.2044 10.1332 3.2637 13.3904
SNU-886 CTRP2 5.9931 8.5676 4.7398 5.5834
HuH-6 CTRP2 6.1456 7.7523 5.2732 3.0513
JHH-1 CTRP2 6.196 7.5568 5.4105 2.3858
Hep 3B2.1-7 CTRP2 6.2574 8.7977 4.841 4.6619
HuH-1 CTRP2 6.276 7.7291 5.3864 2.3497
SNU-878 CTRP2 6.3538 8.467 5.0803 3.4932
SK-HEP-1 CTRP2 6.3636 7.9112 5.3618 2.3085
JHH-2 CTRP2 6.3918 9.8528 4.4214 6.1799
Li-7 CTRP2 6.4334 8.4078 5.1691 2.9931
HLF CTRP2 6.4652 7.9045 5.4374 1.8444
Hep-G2 CTRP2 6.546 9.4384 4.7452 4.5659
SNU-423 CTRP2 6.5978 9.5939 4.7071 4.6392
SNU-449 CTRP2 6.6045 8.5684 5.2132 2.5491
SNU-475 CTRP2 6.6561 9.7506 4.673 4.6856
JHH-5 CTRP2 6.6795 8.1656 5.4548 1.4873
JHH-6 CTRP2 6.8296 8.4976 5.394 1.5382
JHH-4 CTRP2 6.9389 8.463 5.4741 1.1242
SNU-387 CTRP2 7.0449 9.5 5.0623 2.5494
PLC/PRF/5 CTRP2 7.5093 9.2594 5.4314 0.7828
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 139 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1184 CTRP2 2.8567 6.7077 2.3642 22.9787
HCC2935 CTRP2 3.4865 9.4063 1.9422 22.737
NCI-H1694 CTRP2 3.513 4.9803 3.4835 16.9638
NCI-H2141 CTRP2 4.6019 9.4945 3.0074 15.8194
NCI-H1341 CTRP2 4.6733 6.2363 4.4916 9.7783
COR-L95 CTRP2 4.7603 6.5145 4.4914 9.5254
DMS 79 CTRP2 4.8226 7.355 4.2159 10.4235
COLO 668 CTRP2 4.8851 7.7376 4.1085 10.6912
EPLC-272H CTRP2 5.0185 9.0845 3.603 12.4241
NCI-H211 CTRP2 5.0294 7.8395 4.2056 9.9404
NCI-H1105 CTRP2 5.1416 9.1349 3.6947 11.7642
SW1271 CTRP2 5.4044 18.7867 -0.8676 26.65
DMS 273 CTRP2 5.4445 7.4903 4.7761 6.6141
DV-90 CTRP2 5.4574 7.5332 4.768 6.617
NCI-H2405 CTRP2 5.4578 9.0948 4.0065 9.7681
NCI-H2081 CTRP2 5.5309 7.4321 4.8869 5.9566
EBC-1 CTRP2 5.5457 7.794 4.7257 6.587
NCI-H661 CTRP2 5.5463 10.9655 3.1573 13.0867
NCI-H2171 CTRP2 5.5559 6.1703 5.4723 3.5537
NCI-H526 CTRP2 5.5914 6.2969 5.4638 3.4846
NCI-H69 CTRP2 5.6035 9.6155 3.8793 9.9847
NCI-H1581 CTRP2 5.6315 8.2244 4.5937 6.9446
Calu-6 CTRP2 5.6576 7.757 4.8476 5.8304
LXF 289 CTRP2 5.6764 9.6643 3.9193 9.6653
NCI-H1734 CTRP2 5.6778 7.4171 5.0329 5.0165
NCI-H520 CTRP2 5.6952 7.3141 5.0993 4.7023
NCI-H2029 CTRP2 5.7189 7.2197 5.1675 4.3662
NCI-H2196 CTRP2 5.7443 8.5845 4.5163 7.0268
NCI-H810 CTRP2 5.7609 6.9181 5.3534 3.5022
DMS 53 CTRP2 5.7886 7.1968 5.2432 3.8963
DMS 114 CTRP2 5.7906 7.7759 4.959 5.0768
NCI-H1693 CTRP2 5.805 10.5932 3.5675 10.8661
HCC827 CTRP2 5.8586 8.3527 4.732 5.886
VMRC-LCD CTRP2 5.864 7.9143 4.9551 4.9392
NCI-H1385 CTRP2 5.8708 9.1279 4.3557 7.4402
Lu-99 CTRP2 5.8714 6.8302 5.4994 2.6482
HARA [Human squamous cell lung carcinoma] CTRP2 5.8777 7.3119 5.2668 3.6052
NCI-H1339 CTRP2 5.8851 6.9647 5.4456 2.8421
Calu-3 CTRP2 5.9117 7.8841 5.0117 4.6039
NCI-H727 CTRP2 5.9189 8.3112 4.8048 5.4579
NCI-H1915 CTRP2 5.9634 7.123 5.4362 2.7174
LCLC-97TM1 CTRP2 5.9747 7.7311 5.1423 3.9285
HCC1833 CTRP2 5.9951 10.9589 3.546 10.5774
NCI-H522 CTRP2 6.0056 8.0111 5.0286 4.3454
NCI-H322 CTRP2 6.0118 6.8141 5.632 1.7974
NCI-H446 CTRP2 6.0338 10.3262 3.8946 9.0509
NCI-H841 CTRP2 6.0473 6.9044 5.6168 1.7916
HCC4006 CTRP2 6.0829 8.5825 4.8073 5.1259
NCI-H2009 CTRP2 6.1063 9.802 3.4819 5.1189
RERF-LC-MS CTRP2 6.1297 7.1447 5.5636 1.8622
DMS 454 CTRP2 6.133 8.9209 4.6794 5.5689
COLO 699 CTRP2 6.1355 10.272 4.0061 9.6834
LK2 CTRP2 6.1513 6.9603 5.6722 1.3697
NCI-H1092 CTRP2 6.1641 8.2657 5.0319 4.0304
NCI-H889 CTRP2 6.2258 9.2549 4.5877 5.7817
HCC95 CTRP2 6.2584 7.674 5.4003 2.3213
NCI-H1703 CTRP2 6.2651 8.6685 4.1203 2.2124
NCI-H650 CTRP2 6.2885 9.713 4.4093 6.4154
NCI-H1944 CTRP2 6.3029 9.0271 4.7626 4.9091
HCC2108 CTRP2 6.303 9.9097 4.3228 6.7517
NCI-H838 CTRP2 6.3851 7.7991 5.4322 1.9854
LC-1/sq-SF CTRP2 6.4328 7.6002 5.5616 1.3909
SK-MES-1 CTRP2 6.4458 8.1629 5.2982 2.4414
NCI-H1435 CTRP2 6.4771 9.2586 4.7821 4.5271
NCI-H1299 CTRP2 6.4788 8.4644 5.1746 2.8981
NCI-H1573 CTRP2 6.4856 9.1665 4.834 4.297
NCI-H2106 CTRP2 6.4878 10.7754 4.0375 7.6129
COR-L105 CTRP2 6.49 8.8177 5.0093 3.5627
HCC44 CTRP2 6.5115 12.1985 3.3474 10.4229
ChaGo-K-1 CTRP2 6.5187 8.3349 5.2663 2.4607
NCI-H2170 CTRP2 6.5295 7.9286 5.4694 1.6251
NCI-H1568 CTRP2 6.5515 8.9314 4.1666 1.7174
NCI-H647 CTRP2 6.561 9.6335 4.6601 4.8943
NCI-H2085 CTRP2 6.5799 9.5626 4.7092 4.6596
LUDLU-1 CTRP2 6.6091 8.2332 5.3773 1.8829
NCI-H1623 CTRP2 6.6326 8.7839 5.1285 2.8519
NCI-H23 CTRP2 6.6802 8.8166 5.1457 2.7126
A-549 CTRP2 6.6839 9.9263 4.6072 4.9131
NCI-H2291 CTRP2 6.699 9.6676 4.7451 4.3201
NCI-H1666 CTRP2 6.706 15.072 2.0695 15.0637
NCI-H1155 CTRP2 6.743 9.5575 4.8305 3.9016
RERF-LC-Ad2 CTRP2 6.7493 8.2227 5.4716 1.3391
RERF-LC-Ad1 CTRP2 6.8007 7.8315 5.6746 0.5684
SHP-77 CTRP2 6.89 9.3523 5.031 2.8775
HOP-92 CTRP2 6.9008 11.1395 4.1706 6.3662
NCI-H358 CTRP2 6.9074 9.809 4.8237 3.685
NCI-H1869 CTRP2 6.9296 9.0418 5.2035 2.1466
NCI-H2126 CTRP2 6.9457 8.5093 5.4573 1.1772
Sq-1 CTRP2 7.0277 13.4368 3.1323 10.3886
NCI-H196 CTRP2 7.0443 11.8966 3.904 7.2304
COR-L51 CTRP2 7.0448 9.1355 5.2316 1.8998
T3M-10 CTRP2 7.0624 10.2369 4.7239 3.8659
HCC15 CTRP2 7.0927 9.5575 5.0657 2.476
MOR/CPR CTRP2 7.1098 8.0457 5.732 0.2236
HCC78 CTRP2 7.1323 9.6201 5.0614 2.4436
NCI-H1755 CTRP2 7.1799 10.322 4.7618 3.553
SK-LU-1 CTRP2 7.2644 11.6512 4.1811 5.7631
BEN CTRP2 7.289 8.3254 5.7009 0.2169
SBC-5 CTRP2 7.3036 8.363 5.6928 0.2276
COR-L88 CTRP2 7.3064 27.3641 -3.5829 28.6407
NCI-H226 CTRP2 7.3581 21.9358 -0.8347 22.8554
NCI-H2030 CTRP2 7.3664 12.0875 4.041 6.1785
NCI-H2286 CTRP2 7.3693 13.7923 3.2115 9.5089
LOU-NH91 CTRP2 7.3787 9.5298 5.2479 1.4862
HOP-62 CTRP2 7.4366 13.6819 3.3146 8.9914
LCLC-103H CTRP2 7.4534 8.8561 5.5677 0.444
NCI-H292 CTRP2 7.4748 12.6259 3.856 6.7629
NCI-H1838 CTRP2 7.5179 10.1238 5.0624 2.004
HCC366 CTRP2 7.5298 10.3434 4.9704 2.3261
KNS-62 CTRP2 7.5468 9.9238 5.1674 1.6047
NCI-H1395 CTRP2 7.5643 11.2989 4.55 3.8815
NCI-H460 CTRP2 7.624 9.392 5.4321 0.7044
NCI-H2172 CTRP2 7.6379 13.1469 3.7175 7.0772
HCC1588 CTRP2 7.6884 9.9419 5.2351 1.2532
NCI-H2110 CTRP2 7.7223 9.622 5.3851 0.773
NCI-H1650 CTRP2 7.7241 13.078 3.8099 6.5853
HCC1195 CTRP2 7.7763 12.9919 3.8864 6.2086
NCI-H1563 CTRP2 7.8188 16.8695 2.03 13.2801
NCI-H2342 CTRP2 7.937 10.5167 5.119 1.4227
NCI-H2122 CTRP2 7.9565 12.0144 4.4624 3.7376
NCI-H2023 CTRP2 7.9697 11.9119 4.5176 3.5148
Calu-1 CTRP2 8.0266 11.5997 4.6931 2.8049
RERF-LC-A1 CTRP2 8.242 16.368 2.5796 10.5958
NCI-H1651 CTRP2 8.2773 12.6708 4.3553 3.7701
CAL-12T CTRP2 8.3037 10.3167 5.3713 0.4975
PC-14 CTRP2 8.3053 10.5953 5.2641 0.7513
HCC1171 CTRP2 8.325 15.4768 3.0668 8.6318
NCI-H2087 CTRP2 8.5389 18.8337 1.5906 13.6843
NCI-H441 CTRP2 8.6641 10.4927 5.4498 0.2332
NCI-H1793 CTRP2 9.1827 22.6981 0.166 17.1804
NCI-H1355 CTRP2 9.3807 23.5255 -0.0958 17.6263
HCC2279 CTRP2 9.4054 17.71 2.7183 8.4744
EKVX CTRP2 9.6558 18.6468 2.4387 9.1521
HCC1438 CTRP2 9.9164 20.4987 1.7334 11.238
NCI-H1792 CTRP2 9.9409 18.7338 2.5783 8.3068
NCI-H2228 CTRP2 9.9518 23.6938 0.2258 15.8899
Lu-65 CTRP2 10.6045 24.6715 0.2025 15.0631
NCI-H1373 CTRP2 11.454 21.424 2.258 7.68
Hs 888.Lu CTRP2 6.1211 8.4694 4.8952 4.6843
⏷ Show the Full List of 139 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 4.4809 10.2185 2.5447 17.9343
TOV-112D CTRP2 2.7289 5.7752 2.4959 22.8953
Caov-3 CTRP2 4.2424 7.7784 3.4339 15.0303
A2780 CTRP2 4.4752 6.9265 4.0304 12.0826
FU-OV-1 CTRP2 5.3326 14.2379 1.3403 20.4096
OVK18 CTRP2 5.3652 7.5698 4.6615 7.2716
SNU-119 CTRP2 5.5882 7.6259 4.8474 5.9869
OV-90 CTRP2 5.6255 6.5882 5.3756 3.7402
COV434 CTRP2 5.6401 7.5658 4.9251 5.548
ONCO-DG-1 CTRP2 5.7953 8.4219 4.6422 6.3931
OAW28 CTRP2 5.9269 9.7883 4.0736 8.5111
IGROV-1 CTRP2 5.9455 7.4216 5.2717 3.4442
RMG-I CTRP2 6.0175 10.5591 3.7646 9.6249
TOV-21G CTRP2 6.1386 7.4302 5.4283 2.4134
OC 314 CTRP2 6.2839 7.3284 5.5894 1.4967
OVCAR-4 CTRP2 6.3077 13.8162 2.3757 14.661
OVTOKO CTRP2 6.4119 8.9274 4.8966 4.1603
OAW42 CTRP2 6.4371 7.4833 5.62 1.1531
Kuramochi CTRP2 6.4714 9.5214 4.6476 5.0967
JHOS-2 CTRP2 6.5185 8.4946 5.1884 2.7795
OVISE CTRP2 6.5323 8.5894 5.152 2.9078
MCAS CTRP2 6.5669 9.1299 4.9125 3.8394
OVCAR-5 CTRP2 6.5797 10.1938 4.3972 5.9562
EFO-27 CTRP2 6.7219 8.1207 5.5018 1.2571
OV7 CTRP2 6.7985 8.7287 5.2666 2.068
TYK-nu CTRP2 6.8061 8.7079 5.2813 2.0007
SNU-8 CTRP2 6.9298 9.6104 4.9343 3.2083
COV362 CTRP2 6.9321 9.2196 5.1216 2.4629
HEY A8 CTRP2 6.9889 9.4454 5.0519 2.6622
DOV13 CTRP2 7.0465 9.0301 5.2809 1.7132
EFO-21 CTRP2 7.1012 8.6415 5.4848 0.9344
JHOM-1 CTRP2 7.1512 11.642 4.1058 6.2395
COV644 CTRP2 7.2409 13.8062 3.1099 10.1212
OV56 CTRP2 7.4048 8.3777 5.7273 0.1336
ES2 CTRP2 7.4512 8.4888 5.7052 0.1803
JHOC-5 CTRP2 8.0328 11.5763 4.7072 2.7475
SNU-840 CTRP2 8.1214 14.4476 3.4223 7.5478
SK-OV-3 CTRP2 8.3488 14.5549 3.5223 6.8503
OVCAR-8 CTRP2 8.6666 15.0906 3.4753 6.6159
OVSAHO CTRP2 11.7108 23.3188 1.5482 9.6611
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 4.7786 11.9553 1.9775 19.3844
Aska-SS CTRP2 5.7016 8.4007 4.5696 6.894
A-204 CTRP2 4.5967 8.5509 3.4467 14.0709
TE 441.T CTRP2 4.5995 8.0797 3.6657 13.1868
Rh41 CTRP2 4.6369 5.9437 4.5346 9.7325
TTC-709 CTRP2 5.4593 7.8568 4.614 7.2457
G-402 CTRP2 5.6722 8.0998 4.6921 6.4458
TE 617.T CTRP2 5.7026 6.5122 5.4879 3.0949
HT-1080 CTRP2 5.9959 6.8264 5.6123 1.9122
Hs 729.T CTRP2 6.2388 7.2965 5.5721 1.6403
Tm87-16 CTRP2 6.4136 9.7158 4.5066 5.7854
RKN CTRP2 6.545 8.0022 5.4447 1.7024
Rh18 CTRP2 6.5849 15.1239 1.9469 15.739
G-401 CTRP2 6.6586 8.9644 5.0592 3.0952
GCT CTRP2 6.7619 9.5949 4.8258 3.892
SK-LMS-1 CTRP2 6.9625 9.5275 4.9957 2.9189
RD CTRP2 7.0242 9.1971 5.1906 2.0801
SK-UT-1 CTRP2 7.0462 10.3355 4.6655 4.1237
MES-SA CTRP2 7.2227 8.4513 5.6238 0.4275
BT-16 CTRP2 7.5931 13.0532 3.7317 7.0863
KYM-1 CTRP2 7.6242 9.8941 5.2221 1.3499
SW982 CTRP2 9.762 27.4758 -1.7531 21.2399
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
P-STS CTRP2 5.5943 9.0187 4.1673 8.8033
SYO-1 CTRP2 9.9757 28.4915 -2.0953 21.6946
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 6.9812 9.4938 5.024 2.782
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 5.9304 8.6235 4.6586 6.0487
MPP 89 CTRP2 6.4363 8.8006 4.9777 3.7819
IST-Mes1 CTRP2 6.8961 9.8512 4.7956 3.8153
NCI-H28 CTRP2 7.0014 9.0053 5.2651 1.8242
ACC-MESO-1 CTRP2 7.2888 9.6477 5.1438 1.9518
NCI-H2452 CTRP2 7.6037 15.1227 2.7301 11.0156
JL-1 CTRP2 7.6242 11.3908 4.5451 3.8247
NCI-H2052 CTRP2 7.7694 12.9314 3.9107 6.1221
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 CTRP2 5.5538 9.2164 4.033 10.9126
VCaP CTRP2 6.0405 7.4914 5.3177 3.0621
PaCa-3 CTRP2 6.088 6.9596 5.6226 1.6907
DU145 CTRP2 6.6121 8.3289 5.3336 2.0533
LNCaP clone FGC CTRP2 7.2909 9.5421 5.1927 1.7709
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 5.1509 8.6509 3.938 10.7425
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 CTRP2 4.9639 6.5296 4.7046 8.1403
23132/87 CTRP2 5.2686 6.5944 5.003 6.1499
ECC10 CTRP2 5.276 7.8092 4.4614 8.3025
GSS CTRP2 5.4232 6.642 5.1445 5.1822
IM95 CTRP2 5.4531 8.1548 4.4634 7.8824
ECC12 CTRP2 5.5795 6.725 5.2673 4.2905
SNU-1 CTRP2 5.6045 7.5474 4.9009 5.7287
Fu97 CTRP2 5.6564 8.2032 4.6268 6.7526
SNU-216 CTRP2 5.7421 7.5335 5.035 4.865
SNU-16 CTRP2 5.9637 6.803 5.5959 2.047
AGS CTRP2 6.0851 7.3674 5.4165 2.5616
Hs 746.T CTRP2 6.0857 8.1295 5.0361 4.1593
SNU-719 CTRP2 6.2136 8.2914 5.0586 3.8286
NUGC-3 CTRP2 6.3524 8.1263 5.2477 2.7993
HuG1-N CTRP2 6.443 8.6071 5.0782 3.3537
SNU-601 CTRP2 6.4773 8.2471 5.2796 2.4692
NUGC-4 CTRP2 6.6573 15.7876 1.6737 16.5852
MKN74 CTRP2 6.7754 13.5587 2.8777 11.84
MKN1 CTRP2 7.0437 9.2143 5.1946 2.0413
MKN7 CTRP2 7.1101 13.9758 2.928 11.06
GSU CTRP2 7.1266 7.8483 5.8107 0.0797
SNU-668 CTRP2 7.1406 10.7521 4.5296 4.5358
SNU-5 CTRP2 7.2478 8.8573 5.4691 0.8628
KATO III CTRP2 7.289 9.4772 5.2208 1.6717
LMSU CTRP2 7.3227 11.3757 4.3541 4.9818
MKN45 CTRP2 7.4104 8.5156 5.6794 0.2147
KE-39 CTRP2 7.49 14.4085 2.9974 10.1604
SNU-620 CTRP2 7.5572 8.7416 5.6547 0.2107
SH-10-TC CTRP2 7.725 8.9321 5.6509 0.1678
SNU-685 CTRP2 6.5511 7.8782 5.5076 1.4452
SNU-1077 CTRP2 6.7882 9.2897 4.992 3.1774
SNG-M CTRP2 7.8515 18.5548 1.2239 16.0185
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 CTRP2 4.9175 7.7262 4.1463 10.4581
SW579 CTRP2 5.4903 7.1077 5.0016 5.5847
8305C CTRP2 6.1671 8.6911 4.0501 2.6189
TT CTRP2 6.2102 14.8911 1.7585 17.1387
8505C CTRP2 6.2888 16.321 1.1083 19.2228
CAL-62 CTRP2 6.3249 8.0782 5.2508 2.8321
FTC-133 CTRP2 6.5848 8.1725 5.39 1.8657
FTC-238 CTRP2 6.7472 7.939 5.5988 0.8743
BHT-101 CTRP2 7.1156 8.7667 5.4383 1.0784
B-CPAP CTRP2 7.1393 9.0055 5.346 1.3771
TT2609-C02 CTRP2 8.1344 9.9712 5.4313 0.4393
ML-1 [Human leukemia] CTRP2 9.7826 25.0136 -0.5341 18.2269
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-25 CTRP2 4.7951 8.1786 3.8159 12.0933
HSC-4 CTRP2 5.3423 7.7401 4.5584 7.7481
SCC-9 CTRP2 5.6454 8.5359 4.4523 7.5043
YD-10B CTRP2 5.6503 8.6341 4.4081 7.6784
HSC-2 CTRP2 5.858 6.4373 5.677 1.9462
BHY CTRP2 6.0696 9.2508 4.4621 6.602
BICR 31 CTRP2 6.0805 8.1695 5.0117 4.2715
FaDu CTRP2 6.1736 7.0127 5.6633 1.3693
BICR 22 CTRP2 6.174 7.3645 5.489 2.0961
PE/CA-PJ15 CTRP2 6.1984 7.5284 5.4265 2.3147
PE/CA-PJ34 (clone C12) CTRP2 6.2116 7.3193 5.5404 1.8167
BICR 6 CTRP2 6.2487 7.5692 5.4449 2.1522
SNU-1076 CTRP2 6.313 7.9149 4.4777 0.8414
CAL-27 CTRP2 6.3844 8.0248 5.3213 2.4429
PE/CA-PJ49 CTRP2 6.4266 7.6582 5.5295 1.5285
Detroit 562 CTRP2 6.4457 8.3285 5.2171 2.7755
SNU-1214 CTRP2 6.4528 10.1145 4.3388 6.4175
CAL-33 CTRP2 6.4645 8.5826 5.1061 3.2036
SNU-899 CTRP2 6.5649 8.2477 5.3405 2.0919
HSC-3 CTRP2 6.5815 8.8605 5.055 3.2295
BICR 16 CTRP2 6.6873 9.067 5.0296 3.1731
BICR 56 CTRP2 6.888 10.2592 4.592 4.6561
PE/CA-PJ41 (clone D2) CTRP2 7.0982 9.4195 5.1333 2.2096
BICR 18 CTRP2 7.126 9.5574 5.0866 2.3545
YD-8 CTRP2 7.2109 14.4819 2.7539 11.5709
SNU-1066 CTRP2 7.7746 11.2574 4.6998 3.0563
SNU-1041 CTRP2 7.8712 15.137 2.916 9.88
SNU-46 CTRP2 8.2109 10.3374 5.3233 0.6532
SCC-4 CTRP2 8.3079 31.942 -5.0698 29.4197
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JMSU-1 CTRP2 3.997 5.2735 3.9638 13.7523
U-BLC1 CTRP2 5.2952 8.2649 4.2613 9.0783
5637 CTRP2 5.9178 9.4392 4.2404 7.8299
CAL-29 CTRP2 5.9667 7.8613 5.0704 4.2464
253J-BV CTRP2 6.0914 7.9311 5.14 3.7118
RT-4 CTRP2 6.146 8.2018 5.0491 3.9914
253J CTRP2 6.1466 7.3141 5.4925 2.1298
647V CTRP2 6.1496 7.1358 5.5837 1.7425
RT-112 CTRP2 6.3008 13.9822 2.2871 15.0114
639V CTRP2 6.3077 7.2951 5.6226 1.3246
BFTC-905 CTRP2 6.3188 8.3617 5.1057 3.4468
SCaBER CTRP2 6.4033 7.6434 5.5206 1.5978
TCCSUP CTRP2 6.4569 9.2017 4.7949 4.5077
UM-UC-3 CTRP2 6.7545 9.5118 4.861 3.7596
VM-CUB-1 CTRP2 6.9609 10.3415 4.6035 4.4996
J82 CTRP2 6.9915 9.7085 4.9288 3.1451
T24 CTRP2 7.2371 8.991 5.4062 1.0767
KU-19-19 CTRP2 7.6088 8.6859 5.6946 0.1316
KMBC-2 CTRP2 7.6523 11.604 4.4631 4.1072
HT-1376 CTRP2 7.729 9.8698 5.2862 1.0604
HT-1197 CTRP2 7.8866 9.1384 5.6384 0.1467
BC-3C CTRP2 8.0477 9.483 5.5766 0.1981
UM-UC-1 CTRP2 8.6716 10.3343 5.5082 0.1542
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.7358 8.6756 5.7438 0.0541

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5715).
2 Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic can... J Pharmacol Exp Ther. 2009 Mar;328(3):758-65.