Details of the Drug

General Information of Drug (ID: DMOQKAD)

• Drug Name: SNF472
• Synonyms: Hexasodium phytate; UNII-ZBX50UG81V; 34367-89-0(Hexasodium phytate); ZBX50UG81V; 34367-89-0; sodium cyclohexane-1,2,3,4,5,6-hexayl hexakis(hydrogen phosphate); Inositol, hexakis(dihydrogen phosphate) hexasodium salt, myo-; Myo-inositol, hexakis(dihydrogen phosphate), hexasodium salt; Q27295268; scyllo-inositol,1,2,3,4,5,6-hexakis(dihydrogenphosphate),hexasodiumsalt; (1R,2R,3S,4S,5S,6S)-cyclohexane-(1,2,3,4,5,6)-hexaylhexakis(hydrogenphosphate),hexasodiumsalt

Indication

Disease Entry	ICD 11	Status	REF
Calcific uremic arteriolopathy	EB90.42	Phase 3	[1]
Calciphylaxis	EB90.42	Phase 3	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 4:
  Molecular Weight; 791.93
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 12
  Hydrogen Bond Donor Count; 6
  Hydrogen Bond Acceptor Count; 24
• Chemical Identifiers:
  Formula: C6H12Na6O24P6
  IUPAC Name: hexasodium;[2,3,4,5,6-pentakis[[hydroxy(oxido)phosphoryl]oxy]cyclohexyl] hydrogen phosphate
  Canonical SMILES: C1(C(C(C(C(C1OP(=O)(O)[O-])OP(=O)(O)[O-])OP(=O)(O)[O-])OP(=O)(O)[O-])OP(=O)(O)[O-])OP(=O)(O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
  InChI: InChI=1S/C6H18O24P6.6Na/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15;;;;;;/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24);;;;;;/q;6*+1/p-6
  InChIKey: DHZIAGCFFSRULK-UHFFFAOYSA-H
• Cross-matching ID:
  PubChem CID: 91667962
  CAS Number: 34367-89-0
  UNII: ZBX50UG81V
  DrugBank ID: DB18232
  TTD ID: DD76HZ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hydroxyapatite (HA)	TTGUHMF	NOUNIPROTAC	Binder	[2]

References

• [1] ClinicalTrials.gov (NCT04195906) Phase 3 Study of SNF472 for Calciphylaxis (Calciphyx). U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of Sanifit.