Details of the Drug

General Information of Drug (ID: DMOUT89)

• Drug Name: Glutamic acid
• Synonyms: D(-)-Glutamic acid; D-(-)-Glutamic acid; D-2-Aminoglutaric acid; D-2-Aminopentanedioic acid; D-Glutamicacid; D-Glutaminic acid; D-Glutaminsaeure; D-glutamate; D-glutamic acid; Gamma-D-Glutamic Acid; Glutamic acid D-form; Glutamic acid, D-; H-D-Glu-OH; L(+)-Glutamic acid; Lopac-G-2128; Q479989WEA; R-(-)-Glutamic acid; Tocris-0217; WHUUTDBJXJRKMK-GSVOUGTGSA-N; glutamate; (2R)-2-aminopentanedioic acid; (R)-2-aminopentanedioic acid; (r)-glutamic acid; 6893-26-1; CHEBI:15966; CHEMBL76232; D-Glu; DGL; MFCD00063112; UNII-Q479989WEA
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 147.13
  Logarithm of the Partition Coefficient (xlogp); -3.7
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 5
• ADMET Property: MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 582.578 micromolar/kg/day [1]
• Chemical Identifiers:
  Formula: C5H9NO4
  IUPAC Name: (2R)-2-aminopentanedioic acid
  Canonical SMILES: C(CC(=O)O)C(C(=O)O)N
  InChI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
  InChIKey: WHUUTDBJXJRKMK-GSVOUGTGSA-N
• Cross-matching ID:
  PubChem CID: 23327
  ChEBI ID: CHEMBL76232
  CAS Number: 6893-26-1
  UNII: Q479989WEA
  DrugBank ID: DB02517
  INTEDE ID: DR2511
• Drug ADMET Endpoint Profile (DAE)NEW: Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
D-aspartate oxidase (DDO) Main DME	DE8PQ7T	OXDD_HUMAN	Substrate	[2]

References

• [1] Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
• [2] Secreted d-aspartate oxidase functions in C. elegans reproduction and development. FEBS J. 2019 Jan;286(1):124-138.