Details of the Drug

General Information of Drug (ID: DMP36KD)

Drug Name
MLN4924
Synonyms
Pevonedistat; 905579-51-3; MLN4924; MLN-4924; MLN 4924; UNII-S3AZD8D215; S3AZD8D215; Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester; ((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate; C21H25N5O4S; [(1s,2s,4r)-4-{4-[(1s)-2,3-Dihydro-1h-Inden-1-Ylamino]-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl}-2-Hydroxycyclopentyl]methyl Sulfamate; Pevonedistat [USAN:INN]; 3gzn
Indication
Disease Entry ICD 11 Status REF
Myelodysplastic syndrome 2A37 Phase 3 [1]
Acute myelogenous leukaemia 2A41 Phase 2 [2]
Advanced malignancy 2A00-2F9Z Phase 1 [3]
Nasopharyngeal carcinoma 2B6B Investigative [4]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 443.5
Logarithm of the Partition Coefficient (xlogp) 1.7
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C21H25N5O4S
IUPAC Name
[(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate
Canonical SMILES
C1CC2=CC=CC=C2[C@H]1NC3=C4C=CN(C4=NC=N3)[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N
InChI
InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1
InChIKey
MPUQHZXIXSTTDU-QXGSTGNESA-N
Cross-matching ID
PubChem CID
16720766
ChEBI ID
CHEBI:95028
CAS Number
905579-51-3
UNII
S3AZD8D215
DrugBank ID
DB11759
TTD ID
D0ZD2M
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
NEDD8-activating enzyme (NAE) TTVKOPM ULA1_HUMAN ; UBA3_HUMAN Modulator [5]
Ubiquitin-like protein Nedd8 (NEDD8) TTNDC4K NEDD8_HUMAN Inhibitor [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [6]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [6]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [6]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [6]
C-C motif chemokine 17 (CCL17) OTIKW21L CCL17_HUMAN Gene/Protein Processing [6]
C-C motif chemokine 22 (CCL22) OTT3QJC2 CCL22_HUMAN Gene/Protein Processing [6]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Gene/Protein Processing [6]
C-X-C chemokine receptor type 3 (CXCR3) OTIGS220 CXCR3_HUMAN Gene/Protein Processing [6]
C-X-C chemokine receptor type 5 (CXCR5) OTVBCQZX CXCR5_HUMAN Gene/Protein Processing [6]
C-X-C motif chemokine 9 (CXCL9) OTMFVZKZ CXCL9_HUMAN Gene/Protein Processing [6]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 -0.3596 4.5732 -1.0957 39.6077
ES8 GDSC2 -4.9881 -3.0279 -4.9883 82.0916
ES1 GDSC2 -3.8566 -0.0587 -3.9101 69.1531
EW-1 GDSC1; GDSC2 -3.0279 -1.18 -3.0288 56.0681
ES7 GDSC1; GDSC2 -2.8533 -0.7624 -2.8562 54.5172
A-673 GDSC1; GDSC2 -2.8298 -0.1048 -2.8471 54.2429
SK-ES-1 GDSC1; GDSC2; CTRP2 -2.783 -1.295 -2.783 53.149
TC-71 GDSC1; GDSC2 -2.7106 1.225 -2.83 53.0128
MHH-ES-1 GDSC1; GDSC2; CTRP2 -2.5621 -0.4374 -2.5627 51.6788
EW-22 GDSC1; GDSC2 -1.8833 0.1249 -1.8894 45.9919
EW-12 GDSC2 -1.7782 0.1828 -1.7841 51.1716
EW-16 GDSC1; GDSC2 -1.7191 3.3369 -2.1836 45.3946
EW-11 GDSC1; GDSC2 -1.3041 2.7784 -1.5893 41.7261
EW-3 GDSC1; GDSC2 -1.2251 0.9717 -1.2461 40.2445
SK-PN-DW GDSC1; GDSC2 -1.117 2.9475 -1.4255 40.235
ES5 GDSC1; GDSC2 -0.7644 3.7336 -1.2565 37.876
HOS GDSC1; GDSC2; CTRP2 -0.7225 3.9262 -0.9644 40.0856
CADO-ES1 GDSC1; GDSC2 -0.6572 3.2885 -1.0116 36.524
ES6 GDSC2 -0.6556 4.621 -1.432 42.2102
EW-13 GDSC1; GDSC2 -0.6141 3.6702 -1.0735 36.5273
CAL-72 GDSC1; GDSC2 -0.4667 2.4556 -0.6125 34.0837
EW-24 GDSC2 -0.2626 3.63 -0.6782 37.6998
EW-7 GDSC1; GDSC2 -0.1111 4.281 -0.7244 32.8996
SaOS-2 GDSC1; GDSC2; CTRP2 0.3142 7.194 -0.7812 35.7115
MG-63 GDSC2; CTRP2 0.8114 4.1177 0.6576 29.7628
CAL-78 GDSC2; CTRP2 0.8137 5.1342 0.4326 30.5017
U2OS GDSC2; CTRP2; CTRP1 0.8803 5.7953 0.3128 30.6714
ES4 GDSC1; GDSC2 0.9524 7.3508 -0.8958 29.2023
CHSA0108 GDSC1; GDSC2 1.7 12.816 -2.8363 32.5786
EW-18 GDSC1; GDSC2 1.8929 8.6147 -0.5928 24.7258
SJSA-1 GDSC2; CTRP2 3.078 8.2378 1.6886 19.4031
Hs 888.T CTRP2 3.4919 9.7817 1.3713 19.569
NOS-1 [Human HNSCC] GDSC2 3.8953 9.6426 0.6258 15.0116
H-EMC-SS GDSC2 3.9013 8.0958 1.399 10.5146
HuO-3N1 GDSC1; GDSC2 4.3649 7.815 1.874 5.7528
HuO9 GDSC2 4.3949 12.1273 -0.2217 18.0025
NY GDSC2 4.4192 9.8033 0.9441 11.8821
CHSA8926 GDSC1; GDSC2 4.8268 8.0997 2.0403 4.0829
G-292 clone A141B1 GDSC1; GDSC2; CTRP2 4.8313 9.9804 2.5019 12.0801
CHSA0011 GDSC1; GDSC2 5.1422 9.0828 1.7801 4.8883
U-CH2 GDSC2 5.8324 7.5491 2.7648 0.3092
SW1353 CTRP2 6.6607 11.9118 2.9772 6.8959
Hs 822.T CTRP2 7.6796 15.1307 2.1257 9.9993
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 209 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -0.0341 4.7807 -0.4019 35.9774
JM1 GDSC1; GDSC2 -1.7448 0.8881 -1.7792 44.8473
Ri-1 CTRP2 -4.7068 -1.1075 -4.7145 65.5005
SU-DHL-16 GDSC1; GDSC2 -4.7029 -3.0406 -4.7029 70.7936
WSU-DLCL2 GDSC1; GDSC2; CTRP2; CTRP1 -4.5413 -2.9294 -4.5413 64.8381
MOLM-13 GDSC2; CTRP2 -4.2446 -2.4828 -4.2446 62.8636
OCI-Ly7 GDSC2 -4.1135 -2.953 -4.1135 74.5718
NB4 GDSC1; GDSC2; CTRP2 -3.8998 -1.847 -3.8999 60.5657
EM-2 GDSC1; GDSC2; CTRP2 -3.5596 -1.8827 -3.5597 58.3127
OCI-M1 GDSC1; GDSC2 -3.5546 -1.313 -3.557 60.6325
IM-9 GDSC1; GDSC2 -3.4827 -2.0717 -3.4828 60.0967
SU-DHL-5 GDSC1; GDSC2; CTRP1 -3.4247 -2.4245 -3.4247 65.3635
PL21 CTRP2; CTRP1 -3.2684 -1.9149 -3.2684 56.3772
OCI-AML-2 GDSC1; GDSC2; CTRP2 -3.2642 -2.1208 -3.2642 56.3492
BONNA-12 GDSC2 -3.225 0.0107 -3.2591 64.4874
BV-173 GDSC1; GDSC2; CTRP2 -3.1486 -1.6043 -3.1486 55.5801
BC-1 GDSC1; GDSC2 -3.1423 0.8512 -3.2432 56.4742
THP-1 GDSC1; GDSC2; CTRP2; CTRP1 -3.1066 -1.3028 -3.1066 55.2997
KMS-34 CTRP2 -3.079 -1.1392 -3.0792 55.1157
Farage GDSC1; GDSC2 -3.0695 1.0191 -3.1858 55.851
CESS GDSC1; GDSC2 -3.0584 -0.8351 -3.0621 56.3026
Jiyoye GDSC1; GDSC2 -2.9722 -0.2436 -2.9878 55.4716
SCC-3 GDSC2 -2.9531 -1.3549 -2.9534 62.9265
U-937 CTRP2; CTRP1 -2.9514 -1.9061 -2.9514 54.2691
JVM-3 GDSC1; GDSC2; CTRP2 -2.9262 -1.4105 -2.9262 54.1015
ALL-PO GDSC1; GDSC2 -2.9221 -1.0073 -2.9234 55.1332
RPMI-8866 GDSC1 -2.9019 -0.9715 -2.9642 36.6368
SKM-1 GDSC1; GDSC2; CTRP2; CTRP1 -2.9016 -1.4478 -2.9016 53.9378
OCI-AML-3 GDSC2; CTRP1 -2.8659 -1.9788 -2.8659 68.1317
MV4-11 GDSC1; GDSC2; CTRP2 -2.8519 -1.8658 -2.8519 53.6078
BL-41 GDSC1; GDSC2 -2.8448 -0.9137 -2.8464 54.4524
DEL GDSC1; GDSC2; CTRP2 -2.8424 -1.2762 -2.8424 53.544
EB2 GDSC1; GDSC2 -2.783 0.0528 -2.8056 53.823
EoL-1 GDSC2 -2.7604 -1.6746 -2.7604 61.0348
Namalwa GDSC1; GDSC2 -2.7424 -0.3125 -2.7516 53.5194
ML-2 GDSC1; GDSC2 -2.726 -0.8885 -2.7272 53.41
JURL-MK1 GDSC1; CTRP2 -2.7058 -1.3499 -2.7058 52.6357
NOMO-1 GDSC1; GDSC2; CTRP2; CTRP1 -2.6788 -1.5869 -2.6788 52.4566
Ki-JK CTRP2 -2.6666 1.3647 -2.716 52.297
SU-DHL-4 GDSC1; GDSC2; CTRP2; CTRP1 -2.6176 0.8396 -2.6392 52.0152
VAL GDSC2 -2.6097 -0.222 -2.6189 59.3072
SUP-M2 GDSC1; GDSC2 -2.6057 -0.2075 -2.6152 52.329
SU-DHL-1 GDSC2; CTRP2 -2.5685 -0.948 -2.5686 51.723
SUP-B8 GDSC1; GDSC2 -2.5611 0.3097 -2.5898 51.9105
Granta-519 GDSC2 -2.5078 1.1562 -2.606 57.6558
MOLT-16 GDSC1; GDSC2; CTRP2 -2.4715 -1.2041 -2.4715 51.078
HEL GDSC1; GDSC2; CTRP2 -2.4625 -0.1912 -2.4638 51.0167
TUR GDSC1; GDSC2 -2.4589 -1.0266 -2.4591 51.0584
CML-T1 GDSC1; GDSC2; CTRP2 -2.3983 -1.589 -2.3983 50.5908
NCO2 CTRP2 -2.3821 0.2855 -2.3868 50.4815
RPMI-8402 GDSC1; GDSC2; CTRP2 -2.3402 0.7608 -2.3535 50.2025
KMS-11 GDSC1; GDSC2; CTRP2; CTRP1 -2.3212 1.5439 -2.3692 50.076
WIL2 NS GDSC2 -2.294 -0.6774 -2.2947 56.34
Peer CTRP2 -2.2635 1.076 -2.2856 49.6991
DoHH2 GDSC2; CTRP2 -2.2372 -0.9291 -2.2372 49.5196
WSU-NHL GDSC1; GDSC2 -2.1958 -0.2674 -2.1991 48.7388
NKM-1 GDSC1; GDSC2 -2.1812 -1.1232 -2.1812 48.6063
M-07e CTRP2 -2.1806 0.4773 -2.186 49.1471
KHM-1B CTRP2 -2.1121 1.6784 -2.161 48.7214
Jurkat GDSC1; GDSC2; CTRP2 -2.1024 -0.3997 -2.1026 48.6238
KMS-27 CTRP2 -2.0751 -0.8813 -2.0751 48.4416
SU-DHL-6 GDSC2; CTRP2 -2.0097 2.8185 -2.1683 48.1334
SU-DHL-8 GDSC1; GDSC2; CTRP2 -1.9525 1.1243 -1.9693 47.649
HC-1 GDSC1; GDSC2 -1.9463 -0.5838 -1.9465 46.5316
MC116 GDSC1; GDSC2; CTRP2; CTRP1 -1.9427 0.6466 -1.9482 47.57
KE-97 CTRP2; CTRP1 -1.9293 0.0319 -1.9299 47.4736
A3/Kawakami GDSC1; GDSC2 -1.9128 -0.2288 -1.9144 46.2399
QIMR-WIL GDSC1; GDSC2 -1.901 0.2103 -1.9093 46.1527
JSC-1 GDSC1; GDSC2 -1.8942 1.3725 -1.9807 46.2444
P12-Ichikawa GDSC1; GDSC2; CTRP2 -1.8726 0.043 -1.8731 47.0964
NALM-6 GDSC1; GDSC2; CTRP2 -1.8662 0.1905 -1.8672 47.0549
SUP-T1 GDSC1; GDSC2; CTRP2 -1.8416 1.0536 -1.8541 46.9102
GDM-1 GDSC1; GDSC2; CTRP2; CTRP1 -1.7878 1.304 -1.8071 46.565
CRO-AP2 GDSC1; GDSC2 -1.7757 1.4312 -1.8619 45.2303
MOLM-6 CTRP2 -1.7754 2.5102 -1.8811 46.5976
ARH-77 GDSC1; GDSC2 -1.7753 1.2252 -1.8392 45.1806
LAMA-84 GDSC1; GDSC2; CTRP2 -1.7554 0.5232 -1.7579 46.3212
CCRF-CEM GDSC1; GDSC2 -1.7199 -0.0844 -1.7216 44.5378
KMS-26 CTRP2 -1.6733 2.2242 -1.7451 45.8928
MOLM-16 GDSC1; GDSC2; CTRP2; CTRP1 -1.6367 2.5329 -1.7369 45.6968
KCL-22 GDSC1; GDSC2; CTRP2 -1.6323 1.766 -1.6689 45.5685
MY-M12 GDSC2 -1.6051 0.4752 -1.6155 49.449
NK-92MI GDSC2 -1.597 1.1019 -1.641 49.384
697 GDSC1; GDSC2 -1.5869 0.3565 -1.5937 43.3814
PF-382 GDSC1; GDSC2; CTRP2 -1.5478 1.5208 -1.5697 44.9838
JVM-2 GDSC1; GDSC2; CTRP2 -1.5199 2.1104 -1.5752 44.8634
RCH-ACV GDSC1; GDSC2; CTRP2 -1.4802 0.6994 -1.4825 44.4918
JJN-3 GDSC1; GDSC2; CTRP2 -1.4779 2.6253 -1.5792 44.6708
BE-13 GDSC2 -1.4758 1.492 -1.5511 48.2363
KMS-12-BM GDSC2; CTRP2 -1.4648 2.8532 -1.5923 44.6301
MOLT-4 GDSC1; GDSC2 -1.4375 0.9112 -1.4621 42.1262
KE-37 GDSC1; GDSC2; CTRP2 -1.4233 0.0334 -1.4234 44.1078
P31/FUJ GDSC1; GDSC2; CTRP2 -1.4151 0.0776 -1.4152 44.0533
L-363 GDSC1; GDSC2; CTRP2 -1.4148 1.1747 -1.4233 44.0729
Hs 445 GDSC1; GDSC2 -1.3634 0.0021 -1.364 41.3855
Kasumi-1 GDSC1; GDSC2; CTRP2 -1.3438 2.0363 -1.3866 43.6809
KMS-21-BM CTRP2 -1.3396 0.1248 -1.3397 43.5513
SR GDSC1; GDSC2; CTRP2 -1.2693 1.2046 -1.2764 43.1034
MHH-CALL-4 GDSC2; CTRP2 -1.2374 1.9798 -1.2728 42.962
H9 GDSC1; GDSC2 -1.2315 0.5453 -1.2372 40.2414
GA-10 GDSC1; GDSC2 -1.2107 1.7677 -1.3032 40.37
SUP-HD1 GDSC1; GDSC2; CTRP2 -1.1976 1.7414 -1.2197 42.6663
PL-21 GDSC1; GDSC2 -1.1946 1.1209 -1.2232 40.0048
ALL-SIL GDSC1; GDSC2; CTRP2 -1.1885 0.9047 -1.1908 42.5526
CMK GDSC1 -1.1799 0.339 -1.394 16.1895
RS4;11 GDSC1; GDSC2; CTRP2 -1.173 0.7868 -1.1743 42.4469
SUP-B15 GDSC2; CTRP2 -1.1696 1.0096 -1.1728 42.43
P32/ISH GDSC1; GDSC2 -1.0927 1.095 -1.1161 39.0871
MM1.S GDSC2; CTRP2 -1.0857 2.6372 -1.1663 42.0692
KYO-1 CTRP2 -1.0663 3.9028 -1.3321 42.3341
SIG-M5 GDSC2 -1.0657 0.5255 -1.0691 44.0438
Ku812 GDSC1; GDSC2; CTRP2; CTRP1 -1.0598 1.9308 -1.0868 41.7659
MOLP-8 GDSC1; GDSC2 -1.034 2.2852 -1.1942 39.0674
A4/Fukuda GDSC1; GDSC2 -1.023 0.7989 -1.0318 38.4135
NU-DHL-1 CTRP2 -1.013 6.6055 -2.008 43.1775
RPMI-6666 GDSC1; GDSC2; CTRP2 -1.0049 1.4221 -1.0128 41.3487
NU-DUL-1 GDSC1; GDSC2; CTRP2; CTRP1 -0.9996 1.2917 -1.0049 41.306
Daudi GDSC2 -0.9658 1.3279 -0.9996 43.153
CTB-1 GDSC1; GDSC2 -0.8654 1.1447 -0.884 37.0632
KMS-20 CTRP2 -0.8554 3.8941 -1.1022 40.9501
MOLT-13 GDSC1; GDSC2; CTRP2 -0.8363 1.7566 -0.8503 40.2466
KY821 GDSC1; GDSC2 -0.8109 1.3576 -0.8404 36.6284
HL-60 GDSC1; GDSC2; CTRP2 -0.7734 0.6256 -0.7735 39.7861
P30/OHK GDSC1; GDSC2 -0.7712 0.2815 -0.7714 36.1532
MHH-CALL-2 GDSC1; GDSC2 -0.7622 0.8618 -0.7681 36.0984
SU-DHL-10 GDSC1; GDSC2; CTRP2 -0.6782 3.6275 -0.8635 39.6615
Raji GDSC1; GDSC2; CTRP2 -0.6506 1.2964 -0.653 38.977
Kasumi-2 CTRP2 -0.6109 1.8754 -0.624 38.7467
L-540 GDSC1; GDSC2; CTRP2 -0.596 1.9079 -0.6099 38.6499
ATN-1 GDSC1; GDSC2 -0.5897 1.2091 -0.6034 34.6093
MHH-PREB-1 GDSC1; GDSC2 -0.5189 3.4051 -0.8927 35.4238
BC-3 GDSC2 -0.5167 3.7572 -0.9938 40.2418
F-36P CTRP2 -0.4768 6.5904 -1.4215 40.0469
DND-41 GDSC1; GDSC2; CTRP2 -0.4608 1.5778 -0.4649 37.7201
KOPN-8 GDSC1; GDSC2 -0.4445 1.636 -0.4793 33.4192
OCI-AML-5 GDSC1; CTRP2 -0.4338 3.1378 -0.5318 37.8248
Reh GDSC1; GDSC2; CTRP2 -0.326 1.1603 -0.3264 36.8116
Mono-Mac-1 CTRP2 -0.288 6.4907 -1.1831 38.8383
SEM CTRP2 -0.24 1.4827 -0.2415 36.2436
HPB-ALL CTRP2 -0.1786 4.7879 -0.5611 36.9469
DG-75 GDSC1; GDSC2 -0.1676 3.1315 -0.436 31.9874
P3HR-1 CTRP2; CTRP1 -0.1627 6.1915 -0.9483 37.8451
OPM-2 GDSC1; GDSC2 -0.0876 2.5379 -0.218 30.6919
YT GDSC1; GDSC2 -0.0148 3.4986 -0.3693 31.0283
LC4-1 GDSC1; GDSC2 0.0822 2.6487 -0.0552 29.2293
AMO1 GDSC1; GDSC2; CTRP2; CTRP1 0.1139 4.3411 -0.1407 34.6868
RL GDSC1; GDSC2; CTRP2 0.1454 4.9593 -0.2509 34.9
CTV-1 GDSC1; GDSC2 0.1653 2.868 -0.0105 28.6703
SK-MM-2 GDSC2; CTRP2 0.2058 6.9917 -0.824 36.1999
Mono-Mac-6 GDSC1; GDSC2; CTRP2 0.2119 25.9634 -9.5788 44.817
MLMA GDSC2 0.2165 4.0596 -0.2938 33.5658
TALL-1 [Human adult T-ALL] GDSC2; CTRP2 0.2639 3.3738 0.1805 33.1614
Loucy GDSC1; GDSC2 0.3024 2.417 0.2223 27.0294
BALL-1 GDSC1; GDSC2 0.314 2.5616 0.2112 27.0299
U-698-M GDSC1; GDSC2 0.3358 4.5169 -0.3267 29.3447
KMS-18 CTRP2 0.3684 4.6603 0.0655 33.1687
LP-1 GDSC1; GDSC2; CTRP2; CTRP1 0.4266 4.0602 0.2526 32.3772
NCI-H929 GDSC1; GDSC2; CTRP2 0.4342 2.0552 0.4319 31.7627
KG-1 GDSC1; GDSC2 0.4566 3.6463 0.1007 26.9377
ST486 GDSC1; GDSC2; CTRP2 0.5139 2.0791 0.5119 31.2317
Karpas-299 GDSC1; GDSC2; CTRP2 0.6224 2.2317 0.6196 30.513
MN-60 GDSC2 0.644 5.2031 -0.2656 31.3212
Sc-1 GDSC1 0.6616 3.6015 -1.2836 7.938
Ramos.2G6.4C10 GDSC1; GDSC2 0.6856 5.3498 -0.2822 27.7315
OCI-Ly19 GDSC1; GDSC2; CTRP2 0.7718 1.611 0.7718 29.5102
KMS-28BM CTRP2 0.7918 5.8541 0.198 31.3267
VL51 GDSC1; GDSC2 0.8646 5.3151 -0.0804 26.1367
SET-2 CTRP2 0.8798 1.3345 0.8798 28.7917
U266B1 GDSC1; GDSC2; CTRP2 0.9201 5.6558 0.3993 30.2626
GR-ST GDSC1; GDSC2 0.9249 7.4698 -0.9782 29.6132
Karpas-1106P GDSC1; GDSC2 0.9417 6.2106 -0.3882 27.1975
MOTN-1 CTRP2 0.9821 2.5769 0.9778 28.1258
DB GDSC1; GDSC2; CTRP2 1.0338 2.8589 1.023 27.804
KO52 CTRP2 1.0371 1.5771 1.0371 27.7461
Karpas-422 GDSC1; GDSC2; CTRP2 1.088 2.1582 1.0878 27.4078
ROS-50 GDSC1; GDSC2 1.0882 4.6225 0.4373 22.8428
RC-K8 GDSC1; GDSC2 1.1838 5.8879 0.002 24.5577
HDLM-2 GDSC1; GDSC2; CTRP2 1.1981 4.1428 1.07 27.109
Karpas-231 GDSC1; GDSC2 1.232 5.02 0.4271 22.353
HuT 78 CTRP2 1.3406 4.3698 1.1833 26.2627
MEG-01 GDSC1; GDSC2 1.3436 8.1386 -0.8837 27.7436
EHEB GDSC1; CTRP2 1.398 5.0077 1.1032 26.3585
KMOE-2 GDSC1; GDSC2 1.4258 8.6138 -1.0327 28.0223
L-428 GDSC2; CTRP2 1.4437 2.1288 1.4437 25.0421
ME1 CTRP2 1.4835 5.3732 1.0973 26.1117
HD-MY-Z CTRP2 1.513 4.945 1.027 29.1431
JeKo-1 GDSC1; GDSC2; CTRP2 1.5414 3.9765 1.4633 24.6565
MOLP-2 CTRP2 1.5742 6.9906 0.6452 27.3926
CA46 GDSC1; GDSC2; CTRP2 1.6612 6.1807 1.0343 25.7874
ME1 GDSC1; GDSC2 1.7179 3.6353 1.4768 15.3056
OCI-Ly10 CTRP2; CTRP1 1.7614 4.3786 1.6364 23.3553
K-562 GDSC1; GDSC2; CTRP2 1.8609 6.2304 1.233 24.4825
HT GDSC1; GDSC2; CTRP2; CTRP1 1.8823 5.0818 1.6125 23.061
KM-H2 GDSC1; GDSC2; CTRP2 1.8936 4.4599 1.7644 22.4915
HAL-01 GDSC1; GDSC2 2.1441 3.3294 2.0344 10.912
L-1236 GDSC1; GDSC2; CTRP2 2.1688 7.1551 1.213 23.654
RPMI-8226 GDSC2; CTRP2; CTRP1 2.1915 6.2192 1.5939 22.2002
MHH-CALL-3 CTRP2 2.246 10.6661 -0.2597 28.308
AML-193 CTRP2 2.3031 7.8046 1.0852 23.7337
EJM GDSC1; GDSC2; CTRP2; CTRP1 2.4622 7.7703 1.265 22.6391
BL-70 CTRP2; CTRP1 2.922 6.5134 2.2664 17.6039
TK [Human B-cell lymphoma] GDSC1; GDSC2 3.0113 5.4241 2.002 8.1907
SUP-T11 CTRP2 3.3274 9.6403 1.2807 20.3128
Karpas-45 GDSC1; GDSC2 3.7406 6.5532 2.0406 6.1369
HH [Human lymphoma] GDSC1; GDSC2; CTRP2 4.0693 8.1274 2.7178 12.8734
Karpas-620 GDSC1; GDSC2; CTRP2 7.1961 8.6064 4.7502 0.189
Toledo CTRP2 7.7466 11.2241 3.9607 1.9299
KMM-1 CTRP2 7.8364 16.2141 1.7126 10.0706
REC-1 CTRP2 7.9535 10.25 4.4478 0.4859
⏷ Show the Full List of 209 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 28 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 2.9373 5.4497 2.6602 16.0867
TE8 CTRP2 3.5123 7.7559 2.3445 15.7345
KYSE-270 GDSC1; GDSC2 -3.2648 -0.554 -3.2765 57.9964
T.T GDSC1; GDSC2 -2.409 2.0958 -2.6454 50.5447
OE21 GDSC2 -2.1793 0.4113 -2.2013 55.0512
KYSE-30 CTRP2 -1.3216 1.9047 -1.3555 43.5148
KYSE-450 GDSC1; GDSC2; CTRP2; CTRP1 -1.0331 4.3878 -1.3977 47.612
TE-6 GDSC1; GDSC2; CTRP2 -0.7833 5.8976 -1.7895 38.1932
TE-11 GDSC1; GDSC2; CTRP2 -0.2104 2.8381 -0.2651 36.2163
KYSE-510 GDSC1; GDSC2; CTRP2 0.0359 4.2104 -0.1985 35.1373
KYSE-140 GDSC2; CTRP2; CTRP1 0.2463 5.5118 -0.2925 34.6603
TE-9 GDSC1; GDSC2; CTRP2 0.3171 4.313 0.0856 33.2823
TE-4 GDSC2; CTRP2 0.8097 5.9128 0.1989 31.2646
TE-5 GDSC1; GDSC2; CTRP2 0.8143 4.0145 0.5491 28.6838
TE-14 CTRP2 1.3191 5.0655 1.0023 26.9564
TE-10 GDSC1; GDSC2; CTRP2 1.5915 5.7107 1.1136 25.721
TE-15 GDSC1 2.0832 4.0853 -0.6767 1.1023
KYSE-180 GDSC1; GDSC2; CTRP2 2.5432 6.989 1.6755 20.8929
TE-8 GDSC1; GDSC2 2.6081 7.3645 0.6788 16.5221
KYSE-410 GDSC2; CTRP2; CTRP1 3.0971 10.2378 0.7735 22.7242
KYSE-520 GDSC1; GDSC2; CTRP2 3.1788 7.7949 1.4772 16.4294
KYSE-70 GDSC1; GDSC2; CTRP2 3.4266 6.6912 2.7261 14.4558
OE33 GDSC1; GDSC2; CTRP2 3.9584 8.9576 1.5976 13.7504
KYSE-150 GDSC2; CTRP2 5.0467 16.0136 -0.3289 21.9081
TE-1 GDSC1; GDSC2; CTRP2 5.6561 10.7396 2.8072 9.2316
COLO 680N GDSC1; GDSC2; CTRP2 5.7978 11.564 2.5082 10.2043
OE19 GDSC1; GDSC2; CTRP2 6.4916 14.3833 0.8447 11.9158
EC-GI-10 GDSC1; GDSC2; CTRP2 7.4786 20.8836 -1.6157 19.1592
⏷ Show the Full List of 28 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 4.595 15.6022 -1.196 26.8056
L3.3 CTRP2 -2.8352 -1.936 -2.8352 53.4968
KP-4 GDSC1; GDSC2; CTRP2 -1.6251 1.1544 -1.6365 45.4745
YAPC GDSC1; GDSC2; CTRP2 -0.0032 4.8366 -0.382 35.8092
Panc 03.27 GDSC1; GDSC2; CTRP2; CTRP1 0.1249 4.6089 -0.1877 34.7882
MIA PaCa-2 GDSC2; CTRP2 0.2355 5.4841 -0.2962 34.7093
PaTu 8988t GDSC1; GDSC2; CTRP2 0.361 4.6952 0.0493 33.2444
Panc 10.05 GDSC1; GDSC2; CTRP2; CTRP1 0.5935 4.0279 0.4384 33.5741
PL4 GDSC2 0.7881 7.8873 -1.3076 34.5208
QGP-1 GDSC2; CTRP2; CTRP1 0.9027 14.9211 -3.5777 38.8623
MZ-PC-1 GDSC1; GDSC2 0.9423 10.2241 -2.2689 33.5896
BxPC-3 GDSC1; GDSC2; CTRP2 0.9435 6.4621 0.1603 30.9469
PK-59 CTRP2 0.9792 3.6215 0.9099 28.3635
PSN1 GDSC1; GDSC2; CTRP2 1.0809 3.9631 0.9727 27.8197
CFPAC-1 GDSC1; GDSC2; CTRP2; CTRP1 2.0546 6.7647 1.2448 23.8693
KP-1N GDSC1; GDSC2 2.0617 5.5867 1.022 16.4268
DAN-G GDSC2; CTRP2 2.313 10.8964 -0.3015 28.2468
SW1990 GDSC1; GDSC2; CTRP2 2.3764 8.363 0.9194 24.12
SUIT-2 GDSC1; GDSC2; CTRP2; CTRP1 2.4163 8.1013 1.0748 23.4559
SU.86.86 GDSC2; CTRP2 2.818 7.5323 1.7356 19.9117
PaTu 8902 GDSC1; GDSC2; CTRP2; CTRP1 2.8629 9.5744 0.8581 23.0287
HPAC GDSC2; CTRP2; CTRP1 3.1107 7.9104 1.8694 18.6238
Capan-1 GDSC2; CTRP2 3.3892 9.1754 1.5613 19.1008
Panc 08.13 GDSC1; GDSC2; CTRP2 3.8803 7.4805 2.8384 12.8424
HuP-T3 GDSC2; CTRP2 3.8929 10.8934 1.2075 19.2284
Panc 05.04 CTRP2 4.0386 8.907 2.3128 14.5861
HPAF-II GDSC1; GDSC2; CTRP2 4.0948 8.6658 2.4827 13.7689
TCC-Pan2 CTRP2 4.4988 9.243 2.5737 12.4898
Hs 766T GDSC2; CTRP2 5.4127 12.144 1.9101 13.316
Panc 04.03 GDSC2; CTRP2 5.5374 14.9094 0.63 17.8287
AsPC-1 GDSC1; GDSC2; CTRP2 5.5989 7.7728 4.2361 3.3921
HuP-T4 GDSC2; CTRP2; CTRP1 5.6289 15.6987 0.3102 18.7341
PK-45H CTRP2 5.7812 7.8651 3.4295 1.5984
Capan-2 GDSC1; GDSC2; CTRP2; CTRP1 5.8542 12.8183 1.9281 12.4253
KP-3 GDSC1; GDSC2; CTRP2; CTRP1 5.8606 10.7907 2.9412 8.3201
Panc 02.03 GDSC2; CTRP2 6.063 9.4567 3.7483 4.6681
SNU-213 CTRP2 6.1624 10.3206 3.3979 5.9469
SNU-410 CTRP2 7.0915 13.6467 2.4376 8.3968
PaTu 8988s CTRP2 7.7768 20.224 -1.0862 19.1824
KP-2 GDSC1; GDSC2; CTRP2 10.3562 20.3207 1.3901 8.056
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 76 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 2.5721 10.6093 0.0872 26.371
LOX-IMVI GDSC1; GDSC2; CTRP2 -3.7188 0.5346 -3.7568 58.9624
MZ-MEL-2 GDSC2 -2.2557 0.4174 -2.2803 55.769
IST-MEL1 GDSC1; GDSC2 -2.161 0.5905 -2.1921 48.4617
G-mel GDSC1; GDSC2 -1.883 0.8165 -1.918 46.0536
COLO 679 GDSC1; GDSC2 -1.6144 5.2446 -2.6901 45.4049
A-388 GDSC2 -1.0124 2.6102 -1.2346 44.1129
DJM-1 GDSC1; GDSC2 -1.0043 4.3962 -1.7311 40.4319
A-375 GDSC1; GDSC2; CTRP2; CTRP1 -0.9044 2.0579 -0.933 40.7406
SK-MEL-2 GDSC1; GDSC2; CTRP2 -0.4676 3.3971 -0.6018 38.1498
COLO 783 GDSC1; GDSC2 -0.4358 1.9555 -0.5026 33.48
A-431 GDSC1; GDSC2 -0.3912 4.512 -1.1079 35.5733
CP50-MEL-B GDSC2 -0.1123 4.2075 -0.7004 36.9339
M14 GDSC1; GDSC2 -0.022 5.4747 -1.0784 33.7965
IGR-1 GDSC2; CTRP2 -0.0171 7.0346 -1.0796 37.5992
RPMI-7951 GDSC2; CTRP2 0.467 4.814 0.1363 32.6102
WM35 GDSC2 0.513 7.4772 -1.3927 36.0024
Hs 936.T CTRP2; CTRP1 0.6329 4.9104 0.2933 31.5523
COLO 741 CTRP2; CTRP1 0.6338 20.2359 -6.3902 42.2671
SH-4 GDSC1; GDSC2 0.635 8.5283 -1.758 33.2829
HMV-II GDSC1; GDSC2 0.6508 7.7675 -1.3883 32.0781
Mel Ho GDSC1; GDSC2; CTRP2 0.8412 5.6029 0.3293 30.7467
Mel JuSo GDSC1; GDSC2; CTRP2 0.916 6.5365 0.1045 31.2093
Hs 938.T GDSC1; GDSC2 1.0574 5.8547 -0.1125 25.5495
WM1552C GDSC2 1.3579 5.0236 0.5569 24.0681
A2058 GDSC2; CTRP2 1.4458 6.7213 0.6088 27.9075
WM266-4 CTRP2 1.4755 5.0549 1.1756 25.8632
CJM [Human melanoma] CTRP2 1.6547 4.1016 1.5668 23.9365
451Lu GDSC2 1.7279 5.9273 0.533 22.6751
IGR-37 GDSC1; GDSC2; CTRP2 1.8075 6.1659 1.1977 24.768
WM1799 CTRP2 1.8923 8.6656 0.2896 27.6199
MeWo GDSC1; GDSC2; CTRP2 2.004 7.4628 0.9146 25.1917
SK-MEL-5 GDSC2; CTRP2; CTRP1 2.0934 7.3796 1.0426 24.4816
G-361 GDSC1; GDSC2; CTRP2; CTRP1 2.2558 9.8165 0.1431 27.0549
WM983B CTRP2 2.3676 6.2235 1.7821 20.9954
MMAc-SF GDSC1; GDSC2 2.3698 9.4663 -0.5758 23.1589
WM793 GDSC1; GDSC2; CTRP2 2.3891 8.2169 0.9964 23.8114
Hs 944.T CTRP2; CTRP1 2.3933 6.1215 1.8464 20.6833
MZ-MEL-7 GDSC1; GDSC2 2.518 5.9614 1.2842 13.578
COLO 792 GDSC1; GDSC2; CTRP2 2.5547 7.3541 1.5374 21.3768
Hs 294T CTRP2 2.7034 5.8191 2.2867 18.1506
CP66-MEL GDSC1; GDSC2 2.7872 8.6741 0.1881 18.4633
COLO 829 GDSC2; CTRP2 3.0081 10.7375 0.4492 24.0604
HT-144 GDSC1; GDSC2; CTRP2 3.3275 8.5389 1.7994 18.3389
Hs 852.T CTRP2; CTRP1 3.3908 8.2199 2.0101 17.3587
Hs 934.T CTRP2 3.4009 17.7609 -2.6306 31.1604
WM278 GDSC1; GDSC2 3.422 11.3823 -0.6252 20.402
SK-MEL-3 GDSC1; GDSC2; CTRP2 3.5264 11.4013 0.6192 22.1999
COLO 800 GDSC1; GDSC2; CTRP2 3.559 9.9878 0.7374 18.8474
GAK GDSC1; GDSC2 4.0901 14.303 -1.5423 22.266
SK-MEL-24 GDSC1; GDSC2; CTRP2 4.2481 9.7346 2.1031 14.9529
IGR-39 CTRP2 4.2699 8.3604 2.7958 12.0891
WM115 GDSC1; GDSC2; CTRP2 4.2817 8.6537 2.664 12.6016
A101D GDSC2; CTRP2 4.2907 13.2436 0.4031 21.1742
CHL-1 GDSC1; GDSC2 4.2975 9.2007 1.1506 9.7414
HMCB CTRP2 4.3659 8.7949 2.673 12.3755
K029AX CTRP2 4.4855 10.1961 1.4156 16.047
SK-MEL-1 GDSC1; GDSC2; CTRP2; CTRP1 4.6221 12.3318 1.1477 17.8313
LB2518-MEL GDSC1; GDSC2 4.6319 11.2716 0.379 12.9319
SK-MEL-30 GDSC1; GDSC2; CTRP2 4.6611 10.6751 2.0072 14.4396
IPC-298 GDSC1; GDSC2; CTRP2 4.7038 9.2902 2.7337 11.3913
Hs 895.T CTRP2 5.1456 8.8509 3.3352 7.9861
VMRC-MELG GDSC2 5.2045 7.1583 2.6536 1.0143
Hs 688(A).T CTRP2 5.3076 30.5254 -7.3668 34.4873
UACC-257 GDSC1; GDSC2; CTRP2 5.6293 11.894 1.4463 10.8065
SK-MEL-28 GDSC2; CTRP2; CTRP1 5.7926 11.3691 2.6011 9.835
LB373-MEL-D GDSC1; GDSC2 6.0056 13.3102 0.3483 10.3991
Hs 940.T GDSC1; GDSC2; CTRP2 6.1328 11.3038 2.8934 9.151
WM88 CTRP2 6.2353 11.1308 3.0541 7.2372
MDA-MB-435S CTRP2 6.2685 9.5386 3.8512 3.9523
RVH-421 GDSC2; CTRP2 6.2692 9.6747 3.7864 4.2112
Hs 839.T CTRP2 6.458 7.3733 4.9104 0.1349
SK-MEL-31 GDSC1; GDSC2; CTRP2 7.2251 8.7212 4.7201 0.2286
WT2-iPS GDSC1; GDSC2; CTRP2 7.3949 12.3945 3.2338 4.8956
UACC-62 GDSC2; CTRP2 7.6054 16.1824 0.7286 11.599
EquiPSC Line K2 GDSC1; GDSC2 1.0755 8.9021 -1.5066 30.8968
⏷ Show the Full List of 76 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1; GDSC2 -1.5848 2.3352 -1.7994 43.8881
FLO-1 GDSC2 0.5663 5.8702 -0.6259 33.1738
TE-12 GDSC1; GDSC2 0.6627 7.094 -1.0679 30.9369
ESO-51 GDSC1; GDSC2 1.6806 5.5474 0.6589 19.5914
OACP4 C GDSC2 1.9906 6.9208 0.3205 22.7888
OACM5.1 C GDSC1; GDSC2 2.8522 9.7027 -0.2679 20.405
KYSE-220 GDSC2 3.2533 6.7064 1.5722 11.2507
KYSE-50 GDSC1; GDSC2 3.2693 15.9969 -3.0595 28.8617
ESO-26 GDSC1; GDSC2 3.6454 6.2906 2.0978 6.0369
SK-GT-4 GDSC2 3.9044 8.2365 1.3316 10.913
KYAE-1 GDSC1; GDSC2 4.5888 9.0958 1.4105 7.7743
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 0.636 8.6366 -1.8078 33.4242
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-14 GDSC2 -3.9023 0.842 -4.0493 67.8797
NB69 GDSC2 -2.7436 -0.3861 -2.7511 60.6255
SJNB-13 GDSC1; GDSC2 -2.6197 0.7022 -2.678 52.3638
GOTO GDSC1; GDSC2 -2.0605 4.5233 -2.9191 48.1867
SJNB-10 GDSC1; GDSC2 -1.8755 1.8441 -2.0258 46.1882
SK-N-MC-IXC GDSC1; GDSC2 -1.8211 -0.3754 -1.8216 45.427
CHP-126 GDSC2; CTRP2 -1.3066 3.1073 -1.4576 43.6523
SJNB-17 GDSC2 -1.2254 1.5805 -1.296 45.8091
Kelly GDSC1; GDSC2; CTRP2 -1.0481 5.7401 -1.7715 42.9939
CHP-134 GDSC2 -0.8288 1.873 -0.9101 41.9592
NB1 GDSC1; GDSC2; CTRP2 -0.7007 3.0562 -0.8052 39.6004
MHH-NB-11 GDSC2; CTRP2 -0.5798 3.4961 -0.7366 38.9465
KP-N-YS GDSC2 -0.5372 9.2188 -3.2413 44.287
SK-N-DZ GDSC2 -0.5126 4.8833 -1.3731 41.2229
IMR-5 GDSC1; GDSC2 -0.445 3.0877 -0.7275 34.4443
KP-N-SI9s CTRP2 -0.3721 2.1928 -0.3916 37.1797
SiMa GDSC1; GDSC2 -0.2468 1.9679 -0.3037 31.7713
SJNB-5 GDSC1; GDSC2 0.1919 6.8785 -1.4498 34.0999
TGW GDSC1; GDSC2 0.4044 4.4109 -0.2141 28.5711
SJNB-12 GDSC1; GDSC2 1.0786 4.3127 0.5464 22.3482
SJNB-6 GDSC2 1.1063 8.3713 -1.2239 32.9042
SJNB-7 GDSC2 1.2212 5.8226 0.0692 27.1604
KP-N-RT-BM-1 GDSC2 1.3573 6.656 -0.1722 27.7249
SK-N-BE(2)-M17 GDSC1; GDSC2 1.3901 6.5516 -0.0913 24.2424
NH-6 CTRP2 1.5726 4.2074 1.4623 24.5594
NH-12 GDSC2 2.2197 6.4874 0.7475 19.6127
GI-ME-N GDSC1; GDSC2 2.4896 8.2076 0.1549 19.4961
SK-N-SH GDSC2; CTRP2 3.004 5.7427 2.6384 15.9701
SK-N-BE(2) CTRP2 3.6319 8.9035 1.9258 19.675
CHP-212 GDSC2; CTRP2 3.6466 8.3146 2.2187 15.899
SK-N-AS GDSC2; CTRP2 3.6867 8.5104 2.1655 16.0121
NB(TU)1 GDSC1; GDSC2 3.8872 7.2792 1.7924 7.1759
LA-N-6 GDSC1; GDSC2 4.5616 9.5023 1.194 8.9624
SK-N-FI GDSC1; GDSC2; CTRP2 4.6831 8.1592 3.2759 9.1862
KP-N-YN GDSC2; CTRP2 7.4817 9.3931 4.5751 0.4097
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 0.3891 6.3829 -0.4127 34.4927
SNU-308 CTRP2 0.9801 6.557 0.1665 30.8091
SNU-1196 CTRP2 1.6756 7.6835 0.4787 27.6431
HuCC-T1 GDSC1; GDSC2; CTRP2 3.2038 10.3352 0.8298 22.2573
HuH-28 CTRP2 3.9076 10.0537 1.6321 17.5846
SNU-869 CTRP2 6.0579 8.8976 4.0156 3.591
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 89 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 GDSC1; GDSC2 -5.0858 -2.7911 -5.0865 73.7141
HCC1806 GDSC1; GDSC2; CTRP2 -2.2993 2.5158 -2.4374 49.9371
HCC70 GDSC1; GDSC2 -2.1655 -0.0189 -2.1726 48.4769
HCC1569 GDSC1; GDSC2 -1.9858 2.5345 -2.2761 47.256
COLO 824 GDSC1; GDSC2 -1.6503 2.7943 -1.97 44.6266
Evsa-T GDSC2 -1.0266 3.2215 -1.3967 44.5493
MDA-MB-157 GDSC1; GDSC2; CTRP2 -1.0027 11.1946 -3.7933 44.8912
CAL-51 GDSC1; GDSC2; CTRP2 -0.3535 4.1478 -0.6081 37.733
HCC1954 GDSC1; GDSC2; CTRP2 0.5115 5.0693 0.1201 32.5097
HCC2218 GDSC1; GDSC2; CTRP2 0.5631 4.9865 0.1978 32.0912
HCC1599 GDSC2 0.8438 3.9692 0.4167 27.0978
MCF-7 GDSC1; GDSC2; CTRP2; CTRP1 1.0935 7.8322 -0.1959 31.5344
MDA-MB-361 GDSC1; GDSC2; CTRP2 1.128 16.4215 -4.0781 38.8997
MRK-nu-1 GDSC1; GDSC2 1.556 4.0277 1.1646 17.4731
HCC38 GDSC1; GDSC2 1.5669 7.5766 -0.4003 24.9978
MDA-MB-453 GDSC1; GDSC2; CTRP2 1.9178 10.9666 -0.724 30.5217
HMC-1-8 CTRP2 2.0545 8.3135 0.6095 26.0976
MDA-MB-175-VII GDSC1; GDSC2 2.1823 6.9444 0.4911 18.7823
MDA-MB-468 GDSC1; GDSC2; CTRP2 2.5401 10.369 0.1688 26.1988
HCC2157 GDSC1; GDSC2 2.7099 6.8269 1.0365 14.3395
HCC1143 GDSC1; GDSC2; CTRP2 3.155 5.9259 2.7377 15.1637
UACC-812 GDSC2 3.3663 6.09 1.9747 8.3978
MDA-MB-231 GDSC1; GDSC2; CTRP2 3.4399 9.6104 1.4034 19.5751
CAL-85-1 GDSC1; GDSC2; CTRP2 3.4598 8.9501 1.7366 18.2524
HCC1419 GDSC2 3.5678 15.5409 -2.5839 28.8734
SK-BR-3 CTRP2 3.6598 20.9995 -4.0115 33.0496
BT-549 GDSC1; GDSC2 3.6865 9.9165 0.3233 15.3974
UACC-893 GDSC2 3.6972 8.6815 0.9481 13.7367
AU565 GDSC2; CTRP2 3.7915 10.2548 1.4256 21.3442
YMB-1-E GDSC2 3.9274 12.4241 -0.735 21.5356
Hs 578T GDSC1; GDSC2; CTRP2 4.0099 8.7709 2.3515 14.4969
HCC1500 GDSC1; GDSC2; CTRP2 4.1008 9.0839 2.2853 14.5537
HCC1187 GDSC1; GDSC2 4.2244 11.7048 -0.1432 16.3026
BT-20 GDSC1; GDSC2; CTRP2 4.3749 9.6212 2.2746 13.9804
OCUB-M GDSC1; GDSC2 4.615 9.1983 1.3791 7.8878
MFM-223 GDSC1; GDSC2 4.6663 14.4606 -1.1705 19.5665
MDA-MB-436 GDSC1; GDSC2 4.7017 11.1226 0.5032 12.178
EFM-19 GDSC1; GDSC2 4.8174 9.6573 1.2973 7.9234
JIMT-1 GDSC2; CTRP2 4.8748 11.7813 1.6406 15.4376
EFM-192A GDSC1; GDSC2 5.0306 9.7113 1.4144 6.9287
CAL-148 GDSC2; CTRP2 5.5299 8.0063 4.0682 4.2053
BT-483 GDSC1; GDSC2 5.739 7.3218 2.8102 0.2182
Hs 578Bst CTRP2 5.8371 12.2016 2.2217 11.2914
HDQ-P1 GDSC1; GDSC2; CTRP2 5.9365 9.461 3.655 5.2474
ZR-75-1 CTRP2 6.2328 9.475 3.8575 3.9771
MDA-MB-330 GDSC1; GDSC2 6.2806 15.4384 -0.4832 13.5444
BT-474 GDSC2; CTRP2 6.3916 10.1045 3.6633 4.5313
HCC1395 GDSC2; CTRP2 6.5605 16.5046 0.6446 15.9081
HCC202 GDSC1; CTRP2 6.6035 8.9292 3.3845 0.8316
CAL-120 GDSC1; GDSC2; CTRP2 7.086 10.9039 3.7325 3.3779
MDA-MB-415 GDSC2; CTRP2 7.6605 9.3107 4.6747 0.2017
ZR-75-30 GDSC2; CTRP2 7.6624 9.5778 4.5795 0.3376
KPL-1 CTRP2 8.044 17.7142 1.1327 11.8535
T-47D GDSC1; GDSC2; CTRP2 8.0648 16.119 1.9115 9.0219
HCC1937 GDSC1; GDSC2; CTRP2 8.4537 19.0253 0.7826 12.4674
HCC1428 GDSC1; GDSC2; CTRP2 8.5185 31.8045 -6.212 27.6854
CAMA-1 GDSC1; GDSC2; CTRP2 9.2104 19.2692 1.1687 10.145
BT 145 CTRP2 0.6331 1.6577 0.6326 35.4924
BT 416 CTRP2 0.688 9.0063 -1.1051 35.2103
BT 245 CTRP2 1.9066 12.0678 -1.2505 31.8786
BT 239 CTRP2 2.999 6.7842 2.2392 17.4951
BT 216 CTRP2 3.9643 13.2606 0.1043 22.8855
BT 428 CTRP2 4.2895 14.6711 -0.3083 23.4418
BT 187 CTRP2 4.5267 12.269 1.0957 18.2268
BT 286 CTRP2 4.6 11.1267 1.7288 15.669
BT 112 CTRP2 4.743 7.2556 3.0747 5.4336
BT 333 CTRP2 4.9716 11.6721 1.7779 14.705
BT 330 CTRP2 5.1349 9.9535 2.775 10.3426
BT 179 CTRP2 5.3335 7.0404 3.5491 1.5731
BT 228 CTRP2 5.4233 11.237 2.372 11.4442
BT 231 CTRP2 5.4286 13.9009 1.045 16.5694
BT 224 CTRP2 5.6188 8.3572 3.125 3.4013
BT 504 CTRP2 5.6556 6.9881 4.6588 1.5789
BT 232 CTRP2 5.6769 12.0874 2.1519 11.8606
BT 172 CTRP2 5.7944 8.9404 3.8062 4.8522
BT147 CTRP2 5.8153 8.2634 4.1532 3.3918
BT 328 CTRP2 6.058 7.9492 4.4656 1.8151
BT 359 CTRP2 6.2541 9.8666 3.6835 4.647
BT 248 CTRP2 6.2728 10.6845 3.2996 6.1778
BT 444 CTRP2 6.3098 7.7283 4.7058 0.7174
BT 131 CTRP2 6.3949 11.9082 2.7893 8.0598
BT 440 CTRP2 6.4326 9.4109 4.0196 3.069
BT 320 CTRP2 6.5665 8.4163 4.5459 1.0184
BT 340 CTRP2 6.6236 7.7882 4.824 0.2365
BT 139 CTRP2 6.6271 7.7048 4.856 0.1763
BT 482 CTRP2 6.8354 8.51 4.6373 0.5673
BT 498 CTRP2 6.9586 8.1916 4.8082 0.1617
BT 422 CTRP2 7.0946 19.1668 -0.2672 17.9507
BT 159 CTRP2 7.1757 10.3264 4.0442 2.1567
⏷ Show the Full List of 89 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 -0.1677 2.7945 -0.2168 35.9155
Cancer Drug Sensitivity Data Curated from 69 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-466 CTRP2 -2.8965 -0.3569 -2.8986 53.892
D-423MG GDSC2 -2.8095 0.8754 -2.894 60.3293
H4 GDSC1; GDSC2 -1.8338 0.0176 -1.8375 45.5493
SK-MG-1 GDSC2 -1.4279 4.0867 -2.0891 48.2295
Daoy GDSC1; GDSC2; CTRP2 -1.3495 2.1017 -1.397 43.7286
GB-1 GDSC1; GDSC2; CTRP2 -1.0754 2.8845 -1.1824 42.0623
KNS-60 CTRP2 -1.069 2.0283 -1.1014 41.8407
LN-18 GDSC1; GDSC2; CTRP2 -1.0236 0.8703 -1.0249 41.4537
LNZTA3WT4 GDSC1 -0.7973 3.198 -2.3039 20.8507
GaMG GDSC1; GDSC2; CTRP2; CTRP1 -0.7213 2.8234 -0.801 39.6698
SF126 GDSC2; CTRP2 -0.6339 3.3995 -0.7802 39.2728
AM-38 GDSC1; GDSC2; CTRP2 -0.6181 2.9842 -0.7093 39.021
SF539 GDSC1; GDSC2; CTRP2 -0.0762 5.1305 -0.5376 36.5028
A-172 GDSC1; GDSC2; CTRP2 0.3365 6.595 -0.5424 35.0249
PFSK-1 GDSC2 0.4887 12.7662 -3.9285 41.065
GI-1 GDSC1; GDSC2 0.6383 8.1745 -1.5894 32.7635
TM-31 CTRP2 0.8464 1.2856 0.8464 29.014
D-263MG GDSC1; GDSC2 0.8614 4.2631 0.3315 24.2271
MOG-G-UVW GDSC1; GDSC2 0.9373 7.4673 -0.9648 29.5176
SF295 GDSC2; CTRP2; CTRP1 0.9762 3.6072 0.9084 28.3787
LN-229 GDSC1; GDSC2; CTRP2; CTRP1 1.0411 5.4995 0.578 29.2835
D283 Med GDSC1; GDSC2; CTRP2 1.1016 5.0414 0.7712 28.4393
D-336MG GDSC2 1.2768 7.1962 -0.5032 29.5104
42-MG-BA GDSC1; GDSC2; CTRP2 1.282 7.4817 0.1432 29.9208
D-566MG GDSC2 1.2999 4.4754 0.7201 23.4309
YKG-1 GDSC1; GDSC2; CTRP2 1.39 4.9647 1.1053 26.3762
KNS-81-FD GDSC1; GDSC2 1.399 8.0339 -0.7804 27.1481
D-245MG GDSC2 1.6795 5.7178 0.5806 22.6101
D-392MG GDSC1; GDSC2 1.8331 7.4781 -0.0979 22.755
YH-13 GDSC2; CTRP2 1.8612 6.4761 1.1453 24.7945
ONS-76 GDSC1; GDSC2; CTRP2 1.957 9.3437 0.0564 28.1681
U-118MG GDSC1; GDSC2; CTRP2 1.9728 8.7524 0.3344 27.2428
M059J GDSC2 1.9791 7.6374 -0.0364 24.6258
SF268 GDSC2; CTRP2 2.1907 10.429 -0.2042 28.2971
T98G GDSC1; GDSC2; CTRP2 2.3899 5.2461 2.1223 19.6848
KALS-1 GDSC1; GDSC2; CTRP2 2.4322 13.2661 -1.3161 30.6247
D-247MG GDSC2 2.8469 7.3945 0.8774 16.7056
D-502MG GDSC1; GDSC2 2.995 11.205 -0.8953 22.6551
8-MG-BA GDSC1; GDSC2; CTRP2 3.1403 8.657 1.5591 19.7366
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 3.398 11.4484 -0.6781 20.6861
SNU-738 CTRP2 3.401 11.2977 0.5523 22.733
Becker GDSC1; GDSC2; CTRP2 3.7303 9.7825 1.5976 18.1344
Hs 683 GDSC1; GDSC2; CTRP2 3.9194 10.0352 1.6522 17.4796
Onda 10 GDSC1; GDSC2 4.0277 7.5592 1.7588 7.0547
GOS-3 CTRP2 4.0733 8.7713 2.4113 14.1082
DK-MG GDSC1; GDSC2; CTRP2 4.0959 8.9027 1.7416 12.6955
U-251MG GDSC1; GDSC2; CTRP2 4.1053 12.6005 0.5578 21.0633
MOG-G-CCM GDSC1; GDSC2 4.2063 6.729 2.2871 3.8573
D-542MG GDSC1; GDSC2 4.2705 9.2505 1.1062 10.0333
GMS-10 CTRP2 4.4593 8.9128 2.7007 12.0545
DBTRG-05MG GDSC2; CTRP2 4.6068 9.8221 2.3835 13.0354
CAS-1 GDSC1; GDSC2; CTRP2 4.8127 9.4318 2.7592 11.0583
NMC-G1 GDSC1; GDSC2; CTRP2 4.9048 33.7953 -9.3381 36.9462
CCF-STTG1 CTRP2 4.9311 7.4695 3.1033 4.8331
LN-405 GDSC1; GDSC2 5.0053 10.1694 1.1791 8.1765
SW1088 GDSC1; GDSC2; CTRP2 5.1679 10.3309 2.614 10.9435
KINGS-1 GDSC1; GDSC2 5.187 8.7309 1.9683 3.8932
SNU-626 CTRP2 5.7791 8.007 4.2523 3.0425
U-87MG ATCC GDSC1; GDSC2; CTRP2 5.8038 13.7997 1.399 14.5511
SNU-489 CTRP2 6.1566 9.0314 4.0185 3.4396
KNS-81 CTRP2 6.2158 10.9467 3.1302 6.9574
SNB-75 GDSC1; GDSC2; CTRP2 6.2602 10.9328 3.1692 6.7286
Onda 11 GDSC1; GDSC2 6.278 8.1754 2.7094 0.2448
SNU-1105 CTRP2 6.5968 12.72 2.5382 8.7498
M059K CTRP2 6.9851 10.9227 3.6621 3.7618
KG-1-C CTRP2 7.1022 8.5296 4.7418 0.2284
SNU-201 CTRP2 7.3022 13.2426 2.7745 6.7861
KNS-42 GDSC1; GDSC2; CTRP2 7.6133 13.1841 3.0031 5.504
SW1783 GDSC2; CTRP2 7.9832 9.9784 4.5589 0.2781
⏷ Show the Full List of 69 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1; GDSC2 -0.0458 3.9312 -0.5361 31.8604
TGBC24TKB GDSC1; GDSC2 3.4423 7.5149 1.3249 10.7904
TGBC1TKB GDSC2 4.422 10.68 0.5146 14.2402
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC2; CTRP2 -3.2959 -0.8578 -3.297 56.5433
HEC-151 CTRP2; CTRP1 -1.7668 1.579 -1.7977 46.4441
HEC-265 CTRP2; CTRP1 -1.3345 3.9983 -1.6417 44.0904
MFE-296 GDSC1; GDSC2; CTRP2 -0.98 4.1816 -1.295 41.8847
JHUEM-1 CTRP2 -0.2469 3.7472 -0.4191 36.8087
ESS-1 GDSC2; CTRP2 0.0564 7.2567 -1.0813 37.335
HEC-6 CTRP2; CTRP1 0.8876 7.571 -0.3111 32.5276
AN3-CA GDSC1; GDSC2; CTRP2 0.95 6.3255 0.2145 30.7562
EN GDSC1; GDSC2; CTRP2 1.2598 8.737 -0.3957 31.5787
HEC-1-B CTRP2 1.6773 7.9853 0.3561 28.0385
JHUEM-2 CTRP2; CTRP1 2.3902 9.3881 0.4738 25.6122
HEC-59 CTRP2; CTRP1 2.5909 9.6702 0.5445 24.8311
HEC-251 CTRP2; CTRP1 3.2745 10.8978 0.6267 22.7894
KLE GDSC1; GDSC2; CTRP2; CTRP1 3.3502 7.8326 2.1467 16.9261
MFE-319 GDSC1; GDSC2; CTRP2; CTRP1 3.3818 9.0778 1.6002 18.9708
HEC-1-A CTRP2 3.4766 10.9731 0.7811 21.7567
MFE-280 GDSC2 3.6303 9.5622 0.4549 16.6796
HEC-50B CTRP2 3.9667 11.9433 0.758 20.6834
JHUEM-3 CTRP2 5.0212 8.1658 2.8293 6.3018
HEC-108 CTRP2; CTRP1 6.4351 16.2423 0.6782 16.0111
EFE-184 CTRP2 7.21 11.9905 3.3058 4.8493
Ishikawa (Heraklio) 02 ER- CTRP2; CTRP1 1.8211 4.8081 1.613 23.2489
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB65-RCC GDSC1; GDSC2 -1.4872 3.5432 -1.9885 43.6681
LB2241-RCC GDSC1; GDSC2 -1.1847 2.591 -1.4177 40.5836
SW13 GDSC1; GDSC2 -1.1518 2.0386 -1.2794 39.9755
LB996-RCC GDSC2 -0.6699 5.6678 -1.8417 43.0942
KTCTL-13 GDSC2 0.023 3.1259 -0.2267 34.2873
786-O GDSC1; GDSC2; CTRP2 0.1152 5.0791 -0.315 35.1919
TUHR10TKB CTRP2 0.4062 11.9207 -2.6734 39.0415
KTCTL-140 GDSC2 0.4261 6.03 -0.8396 34.6379
ACHN GDSC1; GDSC2; CTRP2 0.4971 3.0204 0.4598 31.4609
BFTC-909 GDSC1; GDSC2; CTRP2 0.5005 4.2845 0.2902 32.0066
CAL-54 GDSC1; GDSC2; CTRP2 0.6651 3.0297 0.634 30.3236
OS-RC-2 GDSC1; GDSC2; CTRP2 0.8885 7.9285 -0.4514 32.9133
KTCTL-21 GDSC2 1.1593 6.7908 -0.4315 29.7064
KTCTL-195 GDSC2 1.2756 6.2928 -0.0871 27.6741
SW156 GDSC1; GDSC2 1.5318 5.1216 0.6954 19.9305
LB1047-RCC GDSC2 1.5815 4.1334 1.1524 19.8064
NCC010 GDSC2 1.5819 5.3427 0.6501 22.6254
KTCTL-26A GDSC2 1.6875 5.576 0.6529 22.1811
A-704 GDSC1; GDSC2 1.7947 6.2738 0.438 20.3129
KTCTL-1M GDSC2 2.6294 10.3779 -0.7986 25.7102
HA7-RCC GDSC1; GDSC2 2.8787 12.6488 -1.7159 25.9674
KMRC-20 GDSC2; CTRP2 3.5013 9.5432 1.4946 19.0796
UO-31 GDSC1; GDSC2; CTRP2 3.5834 7.1852 2.6739 14.2485
NCC021 GDSC1; GDSC2 3.7342 6.6314 1.997 6.3918
TK-10 GDSC2 4.1589 10.043 0.6309 14.2831
TUHR4TKB CTRP2 4.3358 7.8943 3.084 10.7551
KMRC-1 GDSC2; CTRP2 4.3391 9.2521 2.4238 13.4537
SN12C GDSC1; GDSC2 4.4499 8.962 1.3777 8.2242
769-P GDSC1; GDSC2; CTRP2 4.6004 9.9507 2.3139 13.3322
RXF 393L GDSC1; GDSC2 5.2125 10.4144 1.2005 7.6906
VMRC-RCW GDSC2; CTRP2; CTRP1 5.3687 10.9298 2.4809 11.1037
SNU-1272 CTRP2 5.9084 7.485 4.588 1.5282
RCC10RGB GDSC1; GDSC2; CTRP2; CTRP1 6.0636 13.4744 1.7655 14.2776
VMRC-RCZ GDSC2; CTRP2 6.095 10.8328 3.0973 7.2861
KMRC-2 CTRP2 6.406 10.8399 3.3184 5.8998
Caki-2 CTRP2 6.7196 9.8254 4.0056 2.7759
TUHR14TKB CTRP2 7.0403 9.8171 4.1932 3.7943
A-498 GDSC1; GDSC2; CTRP2 7.2271 17.0669 0.8666 14.0296
Caki-1 GDSC1; GDSC2; CTRP2 8.3721 13.2199 3.4316 3.1345
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 61 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CL-34 CTRP1 -4.3638 2.5683 -4.6536 85.6092
RKO GDSC1; GDSC2; CTRP2; CTRP1 -3.0361 -0.0839 -3.0419 54.7947
HCT 116 GDSC2; CTRP2; CTRP1 -2.0082 0.0175 -2.0089 47.9981
SW48 GDSC2; CTRP2; CTRP1 -1.5675 2.084 -1.6229 45.1756
SNU-81 GDSC1; GDSC2; CTRP2; CTRP1 -0.4643 5.53 -1.0729 39.2892
SNU-175 GDSC2; CTRP2; CTRP1 -0.3538 3.7075 -0.5276 37.5141
CL-40 CTRP1 -0.3232 11.9874 -3.4427 58.6994
SK-CO-1 GDSC1; GDSC2; CTRP2; CTRP1 -0.254 4.4488 -0.5638 37.2376
HCC2998 GDSC2 0.0163 3.9906 -0.4881 35.4279
SNU-1040 GDSC1; CTRP1 0.0859 5.9204 -0.5912 40.5784
NCI-H508 GDSC1; GDSC2; CTRP2; CTRP1 0.2029 4.3164 -0.039 34.0649
LoVo GDSC2; CTRP2; CTRP1 0.2443 3.4337 0.1523 33.3194
SNU-C5 GDSC1; GDSC2; CTRP2; CTRP1 0.2672 6.0301 -0.4287 34.9651
COLO205 GDSC1; GDSC2; CTRP2; CTRP1 0.4043 4.3008 0.1827 32.6769
DiFi GDSC1; GDSC2 0.4465 7.8414 -1.6259 33.6131
GP2d CTRP2; CTRP1 0.6868 4.946 0.3432 42.1146
LS180 GDSC1; GDSC2; CTRP2; CTRP1 0.6963 5.5171 0.1967 31.6477
HCT 15 GDSC2; CTRP2 0.7287 2.8635 0.7095 29.8607
KM12 GDSC2; CTRP2; CTRP1 1.0018 5.0901 0.6495 29.1708
SNU-C4 CTRP2; CTRP1 1.0472 6.0682 0.4066 29.8279
COLO201 CTRP2 1.0601 7.0535 0.0713 30.8452
HT115 GDSC2; CTRP2; CTRP1 1.1149 6.0665 0.4806 29.3693
DLD-1 CTRP2; CTRP1 1.2805 4.5965 1.0722 26.8373
LS411N GDSC1; GDSC2; CTRP2; CTRP1 1.3057 5.1388 0.9683 27.1162
LS513 GDSC1; CTRP2; CTRP1 1.5082 4.6799 1.3015 25.3213
SNU-407 GDSC1; GDSC2; CTRP2 1.5631 5.7198 1.0799 25.9266
SW620 GDSC1; GDSC2; CTRP2; CTRP1 1.5714 7.2513 0.5413 27.7493
T84 GDSC2; CTRP2 1.8235 6.7455 1.0048 25.4039
HT-55 GDSC2; CTRP2; CTRP1 1.9706 6.7037 1.1782 24.3541
HCT 8 CTRP2; CTRP1 2.2502 5.3924 1.9282 20.8077
CaR-1 GDSC2 2.4944 9.2627 -0.3635 24.3048
RCM-1 [Human ESC] GDSC2; CTRP2; CTRP1 2.5026 8.732 0.8841 29.6951
SNU-C1 GDSC1; GDSC2; CTRP2 2.5322 7.454 1.472 21.6822
GP5d GDSC2 2.7607 8.2122 0.3946 19.6768
CCK-81 GDSC1; GDSC2; CTRP2 3.0139 6.5437 2.352 17.0225
SW626 GDSC2 3.1205 9.284 0.1714 19.6868
SW837 GDSC1; GDSC2 3.1783 6.4108 1.6562 9.6503
HCC-56 CTRP2 3.3108 6.3679 2.7366 14.7301
SNU-283 GDSC2 3.6529 6.4881 2.0055 7.4168
CL-11 GDSC2; CTRP2 3.6556 8.8964 1.9521 16.9321
SNU-C2A CTRP2; CTRP1 3.9258 7.4749 2.8861 12.538
SNU-C2B GDSC2 3.9434 8.6459 1.1585 11.8417
SW1116 GDSC1; GDSC2 3.9576 5.7501 2.588 2.7209
COLO 320HSR GDSC1; GDSC2 4.0014 9.5482 0.7553 12.4646
SW1463 GDSC1; GDSC2; CTRP2 4.1534 8.3667 2.6828 12.8188
NCI-H747 GDSC1; GDSC2; CTRP2 4.3231 10.5198 1.7838 16.0533
SW948 GDSC2; CTRP2; CTRP1 4.3891 9.0662 2.561 12.7827
C2BBe1 GDSC2; CTRP2; CTRP1 4.6198 9.4899 2.56 15.4986
SW480 CTRP1 4.8299 22.2869 -3.6476 40.4536
LS123 GDSC1; GDSC2; CTRP2; CTRP1 5.2431 10.4626 2.6109 10.8104
COLO 678 GDSC1; GDSC2; CTRP2; CTRP1 5.4095 10.1329 2.9123 9.2475
SNU-61 GDSC1; GDSC2; CTRP2; CTRP1 5.4162 11.4568 2.2564 11.9262
LS1034 GDSC1; GDSC2; CTRP2 5.4324 8.7157 2.8434 4.3869
OUMS-23 CTRP2 5.6552 10.3057 3.0226 8.3424
CW-2 GDSC2; CTRP2; CTRP1 5.754 8.4215 4.0315 3.9868
COLO 320 CTRP2; CTRP1 6.0483 11.0282 2.9661 9.1128
SW1417 GDSC1; GDSC2; CTRP2 6.1045 7.8925 4.5202 1.5548
HT-29 GDSC1; GDSC2; CTRP2; CTRP1 6.3848 9.7642 3.8214 3.9103
NCI-H716 GDSC1; GDSC2; CTRP2 6.768 8.4506 3.6263 0.2081
MDST8 GDSC2; CTRP2; CTRP1 6.8439 12.8409 2.6551 7.9075
SW403 CTRP1 8.3228 18.2391 1.0712 19.6951
⏷ Show the Full List of 61 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 -0.9333 2.5852 -1.1435 38.3726
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-886 CTRP2 -2.8207 12.8184 -6.3731 51.6451
HLE GDSC1; GDSC2 -1.2015 2.8585 -1.4962 40.8991
Huh-7 GDSC1; GDSC2 -0.5994 13.1585 -5.1524 43.5256
JHH-4 GDSC1; GDSC2; CTRP2 1.4977 6.3682 0.7921 27.1261
SNU-182 CTRP2 1.8037 10.5643 -0.6518 30.654
JHH-5 CTRP2 2.1331 10.5929 -0.3373 28.8462
HLF CTRP2 2.782 6.7882 2.0087 18.9719
JHH-2 GDSC1; GDSC2; CTRP2 2.7908 6.2526 2.2263 18.1247
Li-7 CTRP2 2.7976 8.4055 1.3297 21.4914
SNU-761 CTRP2 2.8298 8.9959 0.5658 19.0297
JHH-1 GDSC2; CTRP2 3.2165 10.4497 0.7871 22.3761
JHH-7 GDSC1; GDSC2 3.4333 6.8954 1.6271 9.1535
SK-HEP-1 GDSC1; GDSC2; CTRP2 3.6748 8.0639 2.3638 15.2517
Hep 3B2.1-7 GDSC1; GDSC2; CTRP2 4.3863 9.7949 2.1992 14.2602
PLC/PRF/5 CTRP2 4.6221 10.425 2.0974 14.1611
SNU-423 GDSC1; GDSC2; CTRP2 4.7546 9.7622 2.5437 12.0678
Hep-G2/C3A GDSC1; GDSC2 4.9383 6.1821 2.9135 0.2797
SNU-449 GDSC1; GDSC2; CTRP2; CTRP1 5.4904 8.7859 3.6496 6.8555
SNU-398 GDSC1; GDSC2; CTRP2; CTRP1 5.6078 14.9698 0.6571 17.5996
HuH-6 CTRP2 5.8944 10.6585 3.0326 7.8858
Hep-G2 CTRP2; CTRP1 6.0539 7.7709 4.5454 1.5183
SNU-878 CTRP2 6.5021 11.7382 2.9496 7.2454
JHH-6 GDSC1; GDSC2; CTRP2; CTRP1 6.7153 12.2577 2.8477 7.3329
HuH-1 GDSC1; GDSC2; CTRP2 6.8187 16.41 0.8872 14.6267
SNU-475 CTRP2 7.0772 8.2316 4.8378 0.0984
SNU-387 GDSC2; CTRP2 7.1154 9.7311 4.2699 1.4545
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 226 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H510A GDSC2 -6.0131 3.8108 -7.0033 70.8707
NCI-H1963 GDSC2; CTRP1 -4.6905 4.7592 -5.475 69.1453
COR-L311 GDSC2 -3.9428 0.7585 -4.0817 68.2583
NCI-H1930 CTRP1 -3.9397 7.6332 -5.5285 73.8413
NCI-H1703 GDSC1; GDSC2 -3.6878 0.7481 -3.8095 60.4672
COR-L279 GDSC2; CTRP1 -3.3478 1.025 -3.4011 69.4896
SCLC-21H CTRP1 -3.1288 -0.5192 -3.131 95.2522
NCI-H526 GDSC1; GDSC2; CTRP2 -3.0388 -0.557 -3.0403 54.8371
Lu-99 CTRP2; CTRP1 -2.6302 -0.7001 -2.6304 52.1324
NCI-H290 GDSC1; GDSC2 -2.6231 0.9529 -2.7054 52.3583
A-427 GDSC2 -2.3917 4.9041 -3.4075 54.6501
NCI-H847 GDSC1; GDSC2 -2.2553 1.897 -2.4432 49.3309
ABC-1 GDSC2 -2.2047 -0.7787 -2.205 55.4547
NCI-H1155 GDSC1; GDSC2; CTRP2 -2.1144 -0.052 -2.1152 48.7041
NCI-H2591 GDSC1; GDSC2 -1.7884 3.0608 -2.186 45.8368
NCI-H1694 GDSC2; CTRP2; CTRP1 -1.7853 20.0149 -8.6039 48.7394
NCI-H209 GDSC1; GDSC2 -1.7434 6.0418 -3.1296 46.5143
LC-2/ad GDSC1; GDSC2 -1.6856 0.6188 -1.7032 44.2839
LCLC-97TM1 GDSC2; CTRP2; CTRP1 -1.6474 5.0024 -2.2181 46.2794
HCC78 GDSC1; GDSC2; CTRP2; CTRP1 -1.5226 1.6864 -1.5514 44.8312
COR-L32 GDSC1; GDSC2 -1.4944 2.8127 -1.8045 43.348
NCI-H2373 GDSC1; GDSC2 -1.3957 1.2143 -1.4397 41.8241
Calu-6 GDSC1; GDSC2; CTRP2; CTRP1 -1.3756 0.6719 -1.3772 43.7948
NCI-H1048 GDSC1; GDSC2; CTRP1 -1.3264 3.903 -1.6138 49.5399
COR-L321 GDSC1; GDSC2 -1.2958 3.3937 -1.7373 42.0386
IST-SL1 GDSC1; GDSC2 -1.0504 3.6816 -1.5526 40.2251
EBC-1 GDSC1; GDSC2; CTRP2; CTRP1 -0.92 4.2381 -1.2418 41.5196
EPLC-272H GDSC2; CTRP2; CTRP1 -0.8921 3.2578 -1.0358 40.9515
LB647-SCLC GDSC2 -0.878 24.134 -10.7625 48.3088
NCI-H146 GDSC1; GDSC2 -0.8675 3.6813 -1.3531 38.6986
HCC1359 CTRP1 -0.8576 23.4366 -9.3488 55.7312
NCI-H82 GDSC1; GDSC2; CTRP1 -0.8301 3.5642 -1.0164 46.0289
NCI-H1299 GDSC1; GDSC2; CTRP2; CTRP1 -0.8178 1.8469 -0.8345 40.1317
RERF-LC-Sq1 GDSC1; GDSC2 -0.8143 4.0725 -1.4173 38.6143
SBC-5 GDSC1; GDSC2; CTRP2 -0.809 5.6087 -1.4719 41.4851
NCI-H2171 GDSC2 -0.7233 5.5389 -1.8478 43.4135
NCI-H250 GDSC2 -0.6743 10.849 -4.1321 45.6333
COR-L303 GDSC2 -0.5764 6.8131 -2.2145 43.186
NCI-H23 GDSC1; GDSC2; CTRP2; CTRP1 -0.5633 6.268 -1.4084 40.3647
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2; CTRP2; CTRP1 -0.5314 2.6933 -0.589 38.3522
HCC44 GDSC1; GDSC2; CTRP2; CTRP1 -0.5074 5.1854 -1.023 39.3507
LC-1/sq GDSC2 -0.4985 8.6995 -2.9659 43.8063
NCI-H2286 CTRP2; CTRP1 -0.452 2.8379 -0.5187 37.8535
HCC15 GDSC2; CTRP2; CTRP1 -0.4506 4.8427 -0.8713 38.7754
DMS 114 GDSC2; CTRP2 -0.4479 6.489 -1.356 39.8076
NCI-H2227 GDSC1; GDSC2 -0.4311 13.2717 -5.0453 42.8825
SBC-3 GDSC2 -0.4305 2.3861 -0.5609 38.2262
SBC-1 GDSC1; GDSC2 -0.2718 6.7471 -1.8702 37.2688
CPC-N GDSC1; GDSC2 -0.1868 5.7665 -1.3704 35.4817
SW1573 GDSC2 -0.1735 6.5767 -1.6953 40.1068
NCI-H1581 GDSC1; GDSC2; CTRP2 -0.1383 4.028 -0.3518 36.216
A-549 GDSC1; GDSC2; CTRP2; CTRP1 -0.1041 3.536 -0.233 35.7409
NCI-H1568 GDSC1; GDSC2; CTRP2; CTRP1 -0.0652 2.2609 -0.0796 35.1235
NCI-H1781 GDSC2; CTRP1 -0.0267 6.7787 -0.9991 45.6831
Ms-1 GDSC1; GDSC2 0.0235 6.9508 -1.6541 35.412
NCI-H2804 GDSC2 0.0246 4.4919 -0.6523 36.0128
RERF-LC-KJ GDSC2; CTRP1 0.0446 10.376 -2.3577 46.4196
Lu-99A GDSC1; GDSC2 0.0499 8.6063 -2.3735 37.1426
LXF 289 GDSC2; CTRP2; CTRP1 0.087 3.5707 -0.0337 34.4528
NCI-H2073 CTRP1 0.1931 11.6094 -2.7488 56.9876
NCI-H1184 CTRP2 0.1975 7.6991 -1.0963 36.8627
COLO 668 GDSC1; GDSC2; CTRP2; CTRP1 0.3557 4.1666 0.1563 37.4151
NCI-H841 GDSC1; GDSC2; CTRP2; CTRP1 0.3662 7.2898 -0.7609 35.4795
RERF-LC-MS GDSC1; GDSC2; CTRP2 0.5298 4.0889 0.3589 31.6848
HCC1833 CTRP2; CTRP1 0.5321 6.5893 -0.3289 33.7668
NCI-H838 GDSC1; GDSC2; CTRP2 0.5534 6.5733 -0.3003 33.6138
PaCa-3 GDSC1; GDSC2 0.6364 3.9745 0.1902 25.7889
NCI-H2122 GDSC2; CTRP2; CTRP1 0.6932 4.815 0.3826 31.0628
NCI-H2170 GDSC1; GDSC2; CTRP2 0.7192 4.2418 0.3842 29.7457
NCI-H596 GDSC1; GDSC2; CTRP1 0.7835 2.4689 0.7788 33.5236
COR-L47 CTRP2 0.8106 8.4991 -0.7654 33.9904
NCI-H187 GDSC1 0.8296 2.5665 -0.6755 2.9662
NCI-H2023 GDSC1; GDSC2; CTRP2; CTRP1 0.839 6.2905 0.1062 31.4564
NCI-H2461 GDSC2 0.9328 8.9192 -1.6523 34.9288
NCI-H2795 GDSC2 0.9598 5.4228 -0.0265 28.7709
EMC-BAC-2 GDSC2 0.9616 6.4397 -0.4704 30.7315
NCI-H1304 GDSC1 0.9657 3.0338 -0.8076 3.6032
NCI-H1993 GDSC1; GDSC2 0.9794 3.287 0.7749 21.6355
NCI-H292 GDSC2; CTRP2 0.9855 6.1206 0.3222 30.2991
NCI-H2110 GDSC1; GDSC2; CTRP2; CTRP1 1.0002 6.046 0.3629 30.1207
LOU-NH91 GDSC1; GDSC2; CTRP2 1.0384 5.8109 0.4801 29.6158
NCI-H2405 GDSC1; GDSC2; CTRP2; CTRP1 1.0973 6.3958 0.3497 29.8516
Lu-134-A GDSC1; GDSC2 1.136 7.6174 -0.8388 28.3101
NCI-H1373 CTRP2; CTRP1 1.1479 4.8046 0.8806 27.9186
LCLC-103H GDSC1; GDSC2; CTRP2; CTRP1 1.1916 4.7886 0.932 27.6028
NCI-H720 GDSC1; GDSC2 1.2021 9.0537 -1.4578 30.2912
NCI-H1437 GDSC2; CTRP1 1.3031 7.4535 0.1768 36.8414
NCI-H322M GDSC1; GDSC2 1.3755 5.7565 0.2557 22.6629
NCI-H810 GDSC1; GDSC2; CTRP2; CTRP1 1.3855 12.1479 -1.7999 37.8413
NCI-H460 GDSC1; GDSC2; CTRP2; CTRP1 1.3924 3.9798 1.3037 25.6833
HCC33 GDSC2; CTRP1 1.4335 15.1266 -3.164 42.0337
NCI-H1339 CTRP2 1.4541 6.3425 0.754 27.3904
KNS-62 GDSC1; GDSC2; CTRP2; CTRP1 1.499 6.6335 0.6982 27.4422
NCI-H650 GDSC2; CTRP2; CTRP1 1.5302 9.235 -0.3313 30.5718
Calu-3 GDSC1; GDSC2; CTRP2; CTRP1 1.547 10.7955 -1.0146 32.3323
NCI-H3122 GDSC1; GDSC2 1.5856 7.1587 -0.1835 23.9782
Lu-139 GDSC1 1.6194 3.4838 -0.6488 1.4666
NCI-H446 GDSC1; GDSC2; CTRP2 1.6363 8.7813 -0.0245 29.3537
NCI-H1341 GDSC1; GDSC2 1.6384 9.5426 -1.2828 28.2118
NCI-H2030 GDSC1; GDSC2; CTRP2; CTRP1 1.8149 8.5714 0.2506 27.9707
NCI-H2810 GDSC2 1.8807 7.7193 -0.1691 25.6265
HOP-62 GDSC1; GDSC2; CTRP2 1.9375 8.1567 0.5554 26.6167
COLO 699 CTRP2; CTRP1 1.9713 9.0321 0.2097 27.6471
COR-L23 GDSC1; GDSC2; CTRP1 1.9851 7.4579 0.8966 28.637
SK-LU-1 GDSC1; GDSC2; CTRP2; CTRP1 2.0187 5.5376 1.6325 22.5732
SW1271 GDSC1; GDSC2; CTRP2 2.0275 8.0354 0.7006 25.8655
NCI-H2369 GDSC2 2.0331 4.4081 1.5203 15.8055
HCC95 CTRP2 2.0433 11.1817 -0.7003 30.1065
NCI-H524 GDSC1; GDSC2; CTRP2 2.0463 9.9925 -0.1471 28.5317
NCI-H2087 GDSC2; CTRP2 2.0608 6.5742 1.3235 23.5668
Lu-135 GDSC1; GDSC2 2.0634 11.3469 -1.7822 28.5396
NCI-H1623 GDSC1; GDSC2; CTRP2 2.0658 7.2229 0.6654 23.6261
NCI-H740 GDSC2 2.0997 14.5221 -3.3267 34.833
NCI-H2081 GDSC1; GDSC2; CTRP2; CTRP1 2.1075 8.5426 0.5646 26.0979
NCI-H1651 GDSC1; GDSC2; CTRP2 2.1478 29.9298 -9.7865 41.5183
NCI-H1105 GDSC1; GDSC2; CTRP2; CTRP1 2.163 7.9141 0.893 24.8114
SK-MES-1 GDSC1; GDSC2; CTRP2 2.2327 6.6775 1.4684 22.5405
Lu-65 GDSC1; GDSC2; CTRP2; CTRP1 2.2571 6.7601 1.4625 22.492
UMC-11 GDSC1; GDSC2 2.3002 7.6768 0.2437 19.6422
NCI-H647 GDSC1; GDSC2; CTRP2 2.3078 4.8323 1.9249 17.0035
NCI-H1944 GDSC1; GDSC2; CTRP2; CTRP1 2.453 6.7265 1.6843 21.1138
DMS 273 GDSC2; CTRP2; CTRP1 2.4861 7.0354 1.5964 21.3477
NCI-H358 GDSC1; GDSC2; CTRP2; CTRP1 2.5099 6.8338 1.7024 20.8856
LK-2 GDSC1; GDSC2 2.545 11.1454 -1.2548 25.303
NCI-H2009 GDSC1; GDSC2; CTRP2; CTRP1 2.5999 9.8807 0.4557 25.1045
ChaGo-K-1 GDSC1; GDSC2; CTRP2; CTRP1 2.621 7.1195 1.7042 23.3649
NCI-H1792 GDSC1; GDSC2; CTRP2; CTRP1 2.6512 5.298 2.3929 17.9165
CAL-12T GDSC2; CTRP2; CTRP1 2.7839 7.268 1.8128 19.7109
RERF-LC-A1 CTRP2 2.7912 10.0532 0.5634 24.2363
HCC1438 CTRP2 2.8023 9.0877 1.0238 22.5969
PC-14 GDSC1; GDSC2; CTRP2 2.9077 7.9704 1.6361 20.0498
NCI-H211 GDSC1; GDSC2; CTRP2 3.0026 7.0101 2.1495 17.8299
NCI-H1734 GDSC2; CTRP2 3.0147 11.1744 0.2461 24.7122
SHP-77 GDSC1; GDSC2; CTRP2; CTRP1 3.0164 7.405 1.9956 18.3855
NCI-H2228 GDSC2; CTRP2 3.0428 9.0557 1.2776 21.0437
NCI-H2731 GDSC1; GDSC2 3.0589 14.7343 -2.6049 28.1888
NCI-H2722 GDSC2 3.1287 11.7723 -1.0653 25.182
NCI-H748 GDSC2 3.1774 14.1085 -2.1923 28.8418
NCI-H1693 GDSC1; GDSC2; CTRP2 3.3827 6.9801 2.5575 15.2305
NCI-H322 CTRP2 3.406 10.0493 1.1605 20.5635
NCI-H1650 GDSC2; CTRP2 3.4527 6.5748 2.8019 14.0911
T3M-10 CTRP2; CTRP1 3.4733 9.019 1.7172 24.5393
EMC-BAC-1 GDSC1; GDSC2 3.4737 7.0399 1.5878 9.2699
HCC1588 CTRP2 3.4895 6.3499 2.9328 13.4844
NCI-H1755 GDSC2; CTRP2; CTRP1 3.5251 8.0858 2.2055 16.2523
HCC366 GDSC1; GDSC2; CTRP2 3.5296 8.7715 1.889 17.4872
LK2 CTRP2 3.5877 10.6682 0.4237 23.7537
LC-1/sq-SF CTRP2; CTRP1 3.5905 9.0379 1.8218 23.6449
IST-SL2 GDSC1; GDSC2 3.6001 14.6019 -2.088 25.2846
HCC827 GDSC1; GDSC2; CTRP2; CTRP1 3.6267 7.3738 2.6332 14.2989
NCI-H727 GDSC1; GDSC2; CTRP2; CTRP1 3.6628 8.4865 2.1536 16.118
NCI-H1975 GDSC1; GDSC2; CTRP1 3.6772 9.0453 1.9018 19.3598
NCI-H2595 GDSC1; GDSC2 3.6914 7.5345 1.5151 9.1434
NCI-H513 GDSC1; GDSC2 3.7057 9.5569 0.5182 14.3813
NCI-H1355 GDSC1; GDSC2; CTRP2; CTRP1 3.758 9.0305 1.9865 16.5503
COR-L51 CTRP2; CTRP1 3.8402 7.8205 2.6405 13.737
DV-90 CTRP2; CTRP1 3.856 7.8856 2.6254 18.7237
Sq-1 CTRP2; CTRP1 3.876 8.4173 2.3932 14.6455
LUDLU-1 CTRP2 3.8868 7.7987 2.6965 13.3974
NCI-H1838 GDSC1; GDSC2; CTRP2 3.9023 7.5479 2.8289 12.8261
NCI-H1435 GDSC1; GDSC2; CTRP2; CTRP1 3.9438 7.6286 2.8321 12.7114
NCI-H2869 GDSC1; GDSC2 3.9979 10.4808 0.289 14.806
NCI-H522 GDSC1; GDSC2; CTRP2; CTRP1 4.0099 10.0334 1.737 16.9409
MOR/CPR CTRP2 4.0405 7.7705 2.86 12.3647
NCI-H520 GDSC1; GDSC2; CTRP2 4.0579 9.0349 2.2689 14.7188
NCI-H1770 GDSC1; GDSC2 4.1521 10.2301 0.533 13.2425
VMRC-LCD GDSC1; GDSC2; CTRP2; CTRP1 4.157 12.089 0.8575 22.2897
DMS 53 GDSC1; GDSC2; CTRP2 4.1668 10.7328 1.5371 17.3587
NCI-H2803 GDSC2 4.1714 6.9928 2.1371 5.359
NCI-H1436 GDSC1; GDSC2 4.209 7.1899 2.068 5.016
NCI-H1869 GDSC1; GDSC2; CTRP2 4.2391 6.8495 3.4867 9.344
NCI-H345 GDSC1; GDSC2 4.2452 5.3196 2.9473 0.6088
NCI-H835 GDSC1; GDSC2 4.4313 8.7452 1.47 7.7729
NCI-H64 GDSC2 4.4564 6.7619 2.4302 3.0752
NCI-H1688 GDSC1; GDSC2 4.4843 10.6607 0.5704 12.3123
NCI-H1836 GDSC1; GDSC2; CTRP1 4.5544 12.3873 1.061 20.5134
NCI-H661 GDSC1; GDSC2; CTRP2; CTRP1 4.6017 12.7323 0.9303 18.6667
NCI-H2135 GDSC1; GDSC2 4.6292 10.8144 0.6014 11.8467
NCI-H2818 GDSC1; GDSC2 4.7121 10.1928 0.9648 9.8416
NCI-H2444 GDSC1; GDSC2; CTRP2 4.7928 9.2071 2.1497 7.8854
NCI-H1648 GDSC1; GDSC2 4.8628 15.305 -1.4389 20.1268
Lu-165 GDSC1; GDSC2 4.9267 7.0321 2.572 1.4532
RERF-LC-Ad2 CTRP2 4.9859 7.7033 3.0283 5.1696
NCI-H69 GDSC1; GDSC2; CTRP2 4.9889 18.8098 -1.7754 25.9438
IA-LM GDSC1; GDSC2; CTRP2 5.2879 9.1156 2.5554 6.0463
NCI-H2347 GDSC1; GDSC2 5.2999 14.6826 -0.8062 16.7722
NCI-H2066 GDSC1; GDSC2 5.4052 7.3828 2.6547 0.749
NCI-H2126 CTRP2; CTRP1 5.4077 10.9767 2.4893 10.9956
HCC1195 CTRP2; CTRP1 5.4261 6.5266 4.7216 1.6654
NCI-H1573 GDSC1; GDSC2; CTRP2; CTRP1 5.4568 9.464 3.2847 7.6089
HCC4006 CTRP2; CTRP1 5.4801 9.6786 3.1962 7.9353
NCI-H2172 GDSC1; GDSC2; CTRP2; CTRP1 5.5711 8.7752 3.7183 5.5932
NCI-H2029 GDSC1; GDSC2; CTRP2; CTRP1 5.5737 11.8015 2.2119 13.3605
NCI-H1666 GDSC1; GDSC2; CTRP2; CTRP1 5.5796 9.2534 3.4871 6.5431
HCC2279 CTRP2 5.6089 10.9336 2.673 9.8694
NCI-H1915 GDSC1; GDSC2; CTRP2; CTRP1 5.7322 12.5696 1.9554 12.5396
NCI-H2196 GDSC2 5.7859 7.4039 2.7987 0.2558
NCI-H2141 GDSC1; GDSC2; CTRP2; CTRP1 5.7996 11.9954 2.2949 11.0648
COR-L105 GDSC1; GDSC2; CTRP2 5.8123 12.7555 1.9263 12.5081
NCI-H1793 GDSC1; GDSC2; CTRP2; CTRP1 5.8167 8.78 3.9014 4.423
BEN GDSC1; GDSC2; CTRP2; CTRP1 5.9832 11.7256 2.5716 9.6225
NCI-H2106 CTRP2 6.0537 10.1886 3.3836 6.1768
NCI-H1395 CTRP2 6.1989 10.8348 3.1728 6.8103
RERF-LC-Ad1 CTRP2 6.2317 7.3041 4.842 0.3769
NCI-H2291 GDSC1; GDSC2; CTRP2 6.2625 13.8764 1.7192 12.5158
Calu-1 CTRP2 6.2873 13.0791 2.1328 10.8635
NCI-H196 GDSC1; GDSC2; CTRP2 6.2939 8.617 4.3022 2.1544
DMS 79 GDSC1; GDSC2; CTRP2 6.3721 13.1538 2.1597 10.6154
HOP-92 GDSC1; GDSC2; CTRP2 6.4049 8.6986 4.3318 1.9175
COR-L95 GDSC1; CTRP2 6.4417 12.8912 2.3409 9.7833
NCI-H1092 GDSC1; GDSC2; CTRP2 6.5238 8.3067 4.5704 0.9745
NCI-H226 GDSC2; CTRP2 6.6079 9.4247 4.1218 2.4692
COR-L88 GDSC1; GDSC2; CTRP1 6.6541 8.2775 4.6468 0.7402
NCI-H889 CTRP2 6.7178 16.6988 0.6683 15.5565
HCC2108 CTRP2; CTRP1 7.0037 17.0176 0.7258 14.88
NCI-H3255 GDSC1; GDSC2; CTRP1 7.1247 10.4838 3.9456 2.908
NCI-H2342 GDSC1; GDSC2; CTRP2; CTRP1 7.3266 10.9448 3.8548 2.6725
NCI-H1563 GDSC2; CTRP2 7.7123 9.3114 4.6934 0.1529
NCI-H2085 GDSC1; GDSC2; CTRP2 8.0315 10.0752 4.5426 0.2907
DMS 454 CTRP2 8.3784 22.2162 -0.8193 17.541
NCI-H1876 GDSC2; CTRP1 8.4377 20.05 0.277 16.8379
EKVX GDSC1; GDSC2; CTRP2 8.6534 10.9888 4.4521 0.2715
HCC1171 CTRP2 8.885 20.8812 0.1848 13.8039
NCI-H441 GDSC1; GDSC2; CTRP2; CTRP1 9.693 19.5715 1.3321 9.0013
HCC2935 CTRP2; CTRP1 10.3046 26.4832 -1.5391 16.7918
Hs 888.Lu CTRP2 5.085 8.8737 3.2726 8.3674
⏷ Show the Full List of 226 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 -0.9411 1.6627 -1.0044 37.909
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 -1.5934 3.5029 -1.8281 45.6018
H-STS CTRP2 0.8585 1.2161 0.8585 33.2284
P-STS CTRP2 3.8813 11.0153 0.5038 22.4496
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 0.8015 7.8734 -0.5216 33.3877
Yamato-SS CTRP2 5.7211 10.7385 2.8589 8.9029
VA-ES-BJ GDSC1; GDSC2 -4.0731 1.12 -4.2714 62.5812
EW-8 GDSC2 -3.9509 -0.7654 -3.97 70.9689
TTC-709 CTRP2 -2.1769 4.0971 -2.5772 49.2368
Rh41 GDSC1; GDSC2; CTRP2 -1.1904 6.3751 -2.1247 44.0839
STS-0421 GDSC2 -1.1554 1.5812 -1.222 45.1177
GCT GDSC1; GDSC2; CTRP2 -0.6257 4.0932 -0.8923 39.5219
HT-1080 GDSC1; GDSC2; CTRP2; CTRP1 -0.5423 3.9038 -0.7653 38.8747
SW872 GDSC1; GDSC2 -0.469 1.1341 -0.477 33.518
SK-UT-1 GDSC1; GDSC2; CTRP2 0.0129 4.6774 -0.3258 35.5917
G-401 GDSC2; CTRP2; CTRP1 0.1719 5.0007 -0.2326 34.7526
RKN GDSC1; GDSC2; CTRP2; CTRP1 0.8479 4.2338 0.676 29.5814
KYM-1 GDSC1; GDSC2; CTRP2 1.0898 3.9051 0.9909 27.7288
MES-SA GDSC2; CTRP2 1.1444 8.0252 -0.2202 31.4428
Rh18 GDSC1; CTRP2 1.2363 7.6628 0.0229 30.4335
Hs 633.T GDSC1; GDSC2 1.3572 6.9304 -0.2998 25.2923
A-204 GDSC1; GDSC2; CTRP2 1.5209 8.3276 0.0494 29.4752
TE 617.T CTRP2 1.7927 6.9501 0.894 25.8835
BT-12 CTRP2 1.9814 7.8878 0.7149 25.9494
BT-16 CTRP2 2.1179 8.6514 0.5276 26.1925
RD GDSC1; GDSC2; CTRP2 2.8489 9.1034 1.063 22.3331
TE 441.T GDSC2; CTRP2 2.8849 10.7185 0.3396 24.7396
SW982 GDSC1; GDSC2; CTRP2 2.9046 7.9253 1.6529 19.9941
G-402 GDSC1; GDSC2; CTRP2 3.0792 9.8772 0.9275 22.2253
MFH-ino GDSC1; GDSC2 3.128 11.9475 -1.1535 23.2911
Tm87-16 CTRP2 3.6328 9.5155 1.6338 18.2277
SW684 GDSC1; GDSC2 4.7591 6.6149 2.6628 1.2497
Rh30 GDSC1; GDSC2 5.066 14.2168 -0.7491 17.0323
Hs 729.T CTRP2 5.5112 11.4999 2.312 11.5228
SK-LMS-1 GDSC1; GDSC2; CTRP2 5.6508 12.0787 2.1354 11.9745
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 4.5134 8.5678 2.92 11.0316
Caov-3 GDSC2; CTRP2; CTRP1 -2.8933 1.1728 -2.9391 53.7493
TYK-nu GDSC2; CTRP2; CTRP1 -2.6028 1.0124 -2.631 51.9105
JHOC-5 CTRP2; CTRP1 -2.5142 10.3557 -5.0242 50.7709
OC 314 GDSC2; CTRP2 -2.3353 -0.5346 -2.3354 50.1719
TOV-21G GDSC2 -2.1684 1.6042 -2.3033 54.5589
OVCAR-8 GDSC2; CTRP2; CTRP1 -1.249 1.2711 -1.2572 42.9716
JHOS-4 GDSC1; GDSC2; CTRP1 -0.7372 5.2314 -1.2863 45.8293
COV434 CTRP2; CTRP1 -0.4847 6.7206 -1.4744 40.1765
Caov-4 GDSC1; GDSC2 -0.2736 3.4757 -0.6451 33.325
ES-2 GDSC1; GDSC2 0.1303 3.6821 -0.2659 29.9533
IGROV-1 GDSC1; GDSC2; CTRP2; CTRP1 0.7469 5.6286 0.2187 31.4102
DOV13 GDSC2; CTRP2 0.9255 5.5367 0.4409 30.1092
OV-90 GDSC2; CTRP2; CTRP1 0.9374 10.2494 -1.3853 35.0383
A2780 GDSC1; GDSC2; CTRP2; CTRP1 1.1146 8.4103 -0.4099 32.0732
OVK18 GDSC1; GDSC2; CTRP2; CTRP1 1.2403 5.7017 0.734 28.1248
TOV-112D GDSC2; CTRP2 1.4106 5.9294 0.8468 27.207
COV644 CTRP2; CTRP1 1.6341 5.8473 1.1164 25.5808
OVKATE GDSC2; CTRP1 1.8367 17.9276 -4.1405 41.8
MCAS CTRP2 1.8622 7.5397 0.7338 26.232
OV56 GDSC2; CTRP2 1.9885 4.4773 1.8638 21.845
HEY A8 CTRP2; CTRP1 2.2127 9.4533 0.2657 26.7845
ES2 CTRP2 2.6646 6.6295 1.9473 19.5319
SNU-119 CTRP2 3.3221 9.1739 1.4967 19.5138
FU-OV-1 GDSC1; GDSC2 3.7355 6.531 2.0476 6.1097
OVTOKO GDSC2; CTRP2 3.7557 9.0973 1.9522 16.6913
SNU-8 CTRP2 3.8378 12.8397 0.1986 22.8721
OVCAR-3 GDSC1; GDSC2 3.9031 11.4908 -0.2889 17.7269
SK-OV-3 GDSC1; GDSC2; CTRP2; CTRP1 4.5278 9.2041 2.619 12.2405
RMUG-S CTRP1 4.6869 8.3675 3.1763 20.1139
ONCO-DG-1 CTRP2 4.8027 11.6896 1.6245 15.649
COV362 CTRP2; CTRP1 5.064 14.1299 0.6275 24.0495
OV7 CTRP2; CTRP1 5.2131 10.262 2.6862 10.5576
JHOM-1 CTRP2; CTRP1 5.2357 8.2487 3.7116 8.5142
JHOS-2 GDSC2; CTRP2 5.2944 10.5471 2.6111 10.7105
OVISE GDSC1; GDSC2; CTRP2 5.3456 8.4833 3.6846 6.1402
OVCAR-4 GDSC1; GDSC2; CTRP2; CTRP1 5.3571 13.8914 0.9909 16.9046
EFO-21 GDSC1; GDSC2; CTRP2; CTRP1 5.4569 10.0968 2.9688 10.1443
OAW28 GDSC1; GDSC2; CTRP2 5.5083 7.4084 4.3481 3.0777
OVCAR-5 GDSC1; GDSC2; CTRP2 6.1035 10.4409 3.2962 6.4561
SNU-840 CTRP2; CTRP1 6.1169 9.259 3.882 4.0452
RMG-I GDSC1; GDSC2; CTRP2; CTRP1 6.4347 11.4136 3.0598 6.9033
COV318 CTRP1 6.7009 9.5617 4.1148 5.1093
EFO-27 GDSC1; GDSC2; CTRP2; CTRP1 6.763 11.1814 3.3979 5.77
Kuramochi GDSC2; CTRP2 6.7822 13.4009 2.339 9.2499
OVMANA CTRP1 6.795 8.0391 4.8 0.4774
OVSAHO CTRP2 7.3904 13.3846 2.7653 6.7027
OAW42 GDSC1; GDSC2; CTRP2; CTRP1 9.6545 23.2527 -0.4305 14.6155
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 5.6434 7.1239 3.6661 0.7193
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2; CTRP2; CTRP1 -0.8415 3.4054 -1.0034 40.6659
MPP 89 GDSC1; GDSC2; CTRP2 1.1259 5.1322 0.7738 28.3527
NCI-H28 GDSC2; CTRP2; CTRP1 2.0267 7.6933 0.8434 25.3748
ACC-MESO-1 CTRP2 2.7024 8.4655 1.2062 22.2003
NCI-H2052 GDSC2; CTRP2; CTRP1 3.2387 8.9278 1.5305 19.5948
IST-Mes1 GDSC2; CTRP2 4.0546 7.5318 2.9864 11.818
JL-1 CTRP2 4.595 6.3371 3.4169 3.6645
NCI-H2452 GDSC1; GDSC2; CTRP2 5.4615 9.0937 3.4732 6.8126
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 -3.5854 0.8349 -3.7112 65.9635
PC-3 GDSC1; GDSC2 1.3078 9.6726 -1.6562 30.5682
22Rv1 GDSC1; GDSC2; CTRP2 1.3922 6.1493 0.7537 27.5831
DU145 GDSC1; GDSC2; CTRP2 1.9051 6.3796 1.2276 24.3704
PaCa-3 CTRP2; CTRP1 4.6486 8.2987 3.1757 13.1972
VCaP GDSC1; GDSC2; CTRP2 5.2858 13.2089 1.2732 16.0085
NCI-H660 GDSC2; CTRP2 5.5086 17.905 -0.8908 22.6269
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 -0.7769 2.549 -0.8338 39.9745
A-253 GDSC1; GDSC2; CTRP2 0.63 3.9924 0.4837 30.9401
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 -3.877 2.0996 -4.2377 60.4593
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ECC10 GDSC1; GDSC2; CTRP2 -3.6281 -0.1745 -3.6394 58.6066
HSC-39 GDSC1; GDSC2 -0.6546 1.3428 -0.6772 35.2201
RF-48 GDSC1; GDSC2 -0.5191 2.5457 -0.6864 34.6289
NUGC-3 GDSC1; GDSC2; CTRP2 -0.4231 4.5554 -0.7721 38.4256
SNU-1 GDSC1; GDSC2 -0.1182 3.2568 -0.4148 31.6781
GSS CTRP2 -0.0887 5.0041 -0.5178 36.496
TGBC11TKB GDSC1; GDSC2 0.0303 3.47 -0.3118 30.5845
SNU-16 GDSC1; GDSC2; CTRP2 0.5196 2.6805 0.5031 31.2421
SNU-5 GDSC1; GDSC2; CTRP2 0.6653 3.0541 0.6325 30.328
TMK-1 GDSC2 0.8618 4.7496 0.1468 28.3819
OCUM-1 GDSC1; GDSC2; CTRP2 1.1461 4.9155 0.8516 28.0232
AGS GDSC2; CTRP2; CTRP1 1.1818 6.4293 0.4293 29.3247
IM95 GDSC2; CTRP2 1.3195 5.9409 0.7441 27.8417
HGC-27 GDSC1; GDSC2; CTRP2 1.4551 8.9958 -0.3044 30.7216
NCI-N87 GDSC2; CTRP2 1.4596 9.7117 -0.614 31.5638
SNU-216 CTRP2 1.4825 6.4746 0.738 27.3577
SNU-601 CTRP2 1.6355 10.9543 -0.9989 50.4256
ECC12 GDSC2; CTRP2 1.7005 7.3097 0.6554 26.9779
23132/87 GDSC1; GDSC2; CTRP2 1.8363 7.5318 0.7098 26.3903
SNU-620 CTRP2 2.4434 8.519 0.919 23.9368
SNU-668 CTRP2 3.3299 8.2048 1.9564 17.7225
MKN28 GDSC2 3.6027 9.3873 0.5199 16.4077
SK-GT-2 GDSC1; GDSC2 3.6114 14.1666 -1.8611 24.5262
GCIY GDSC2 3.6641 6.4904 2.013 7.3399
SCH GDSC1; GDSC2 4.0388 6.7361 2.1691 4.8048
RERF-GC-1B GDSC1; GDSC2 4.3455 8.1397 1.7036 6.6998
NUGC-4 GDSC2; CTRP2; CTRP1 4.4366 15.8533 -0.7695 24.4644
MKN74 CTRP2; CTRP1 4.5433 11.2069 1.639 16.1394
KE-39 CTRP2 4.6696 11.2612 1.7227 15.5455
SNU-719 CTRP2 4.9296 14.3246 0.4166 19.7674
KATO III GDSC2; CTRP2 4.9982 9.4739 2.8987 10.1003
GSU CTRP2 5.2988 8.622 3.577 6.6785
Hs 746.T GDSC1; GDSC2; CTRP2 5.6058 10.9563 2.6592 9.9318
MKN1 GDSC1; GDSC2; CTRP2 5.6063 7.7588 4.2485 3.329
HuG1-N CTRP2 5.6586 7.6846 4.3233 2.9371
MKN45 GDSC1; GDSC2; CTRP2 6.196 7.2566 4.8446 0.391
MKN7 GDSC1; GDSC2; CTRP2; CTRP1 6.2519 12.157 2.5616 10.4357
Fu97 GDSC1; GDSC2; CTRP2; CTRP1 6.5088 12.0087 2.8225 7.7475
SH-10-TC CTRP2; CTRP1 7.0359 8.5387 4.7121 0.416
LMSU CTRP2 7.5088 12.318 3.3395 4.3603
SNU-1077 CTRP2 -1.8603 0.2674 -1.8616 47.0163
SNG-M GDSC1; GDSC2; CTRP2; CTRP1 -0.0069 4.109 -0.225 35.3688
SNU-685 CTRP2 3.1589 5.0935 2.7263 12.579
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC1; GDSC2 -2.4048 -0.3298 -2.4092 50.5778
CGTH-W-1 GDSC2; CTRP2 -0.7706 1.9198 -0.789 39.8236
CAL-62 GDSC2; CTRP2 -0.6587 3.48 -0.8188 39.4707
ASH-3 GDSC1; GDSC2 -0.3104 3.0375 -0.5683 33.183
B-CPAP GDSC1; GDSC2; CTRP2 0.4647 4.5912 0.1861 32.461
HTC-C3 GDSC1; GDSC2 0.6353 3.9396 0.2007 25.744
8505C GDSC2; CTRP2 0.8749 6.0555 0.2236 30.9725
TT GDSC1; GDSC2; CTRP2 0.8899 3.7642 0.7969 29.037
SW579 CTRP2 0.8999 1.3293 0.8999 28.6584
BHT-101 GDSC2; CTRP2 1.2487 5.1716 0.8972 27.541
ML-1 [Human leukemia] GDSC1; GDSC2; CTRP2 1.5466 4.3315 1.413 24.8129
FTC-238 CTRP2 1.649 4.5444 1.4831 24.2442
K5 GDSC2 1.9529 4.9824 1.1885 18.0718
KMH-2 GDSC1; GDSC2 1.9939 7.1621 0.2075 20.7876
TT2609-C02 GDSC1; GDSC2; CTRP2 2.72 7.268 1.7461 20.1384
8305C GDSC1; GDSC2; CTRP2 3.4845 6.1129 3.0213 13.1589
WRO GDSC1; GDSC2 4.6603 7.1516 2.374 2.6823
FTC-133 GDSC1; GDSC2; CTRP2 6.0908 10.3065 2.5164 4.9235
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SAS GDSC1; GDSC2 -3.9675 -0.3656 -4.0055 63.365
UPCI-SCC-090 GDSC2 -3.6204 -1.3871 -3.6226 69.1697
KON GDSC1; GDSC2 -2.3958 2.1673 -2.6449 50.4397
PCI-38 GDSC1 -2.1269 0.9483 -2.6349 29.7864
HSC-2 GDSC1; GDSC2; CTRP2; CTRP1 -2.1096 2.0871 -2.1906 48.7223
BICR 10 GDSC2 -1.6339 2.1599 -1.8194 49.7609
JHU-022 GDSC1; GDSC2 -1.3736 3.9234 -1.9785 42.9905
PCI-15A GDSC1; GDSC2 -1.1712 1.588 -1.2394 39.9424
JHU-011 GDSC2 -1.1458 3.5028 -1.6044 45.7362
SKN-3 GDSC1; GDSC2 -1.0977 5.1405 -2.0966 41.7201
BICR 78 GDSC1; GDSC2 -1.0926 3.0933 -1.4353 40.1304
JHU-029 GDSC1; GDSC2 -0.7834 3.1392 -1.1098 37.4925
BB30-HNC GDSC2 -0.7524 3.0762 -1.0599 41.912
LB771-HNC GDSC2 -0.7274 7.1018 -2.4943 44.3658
Ca9-22 GDSC1; GDSC2 -0.7062 3.7465 -1.197 37.3939
CAL-27 GDSC2; CTRP2 -0.6743 3.4092 -0.8248 39.5474
NCI-H3118 GDSC1; GDSC2 -0.5091 9.2713 -3.2372 41.0016
KOSC-2 GDSC1; GDSC2 -0.4917 2.8759 -0.7272 34.6629
HO-1-N-1 GDSC1; GDSC2 -0.4798 3.2561 -0.8092 34.9245
HSC-4 GDSC2; CTRP2 -0.4759 4.7892 -0.8857 38.9096
PCI-04B GDSC2 -0.3535 2.3526 -0.4722 37.4183
HO-1-u-1 GDSC1; GDSC2 -0.3491 5.6359 -1.489 36.5731
SNU-1214 CTRP2 -0.3169 7.0603 -1.412 39.41
CAL-33 GDSC2; CTRP2 -0.2911 4.3147 -0.5749 37.4072
Detroit 562 GDSC1; GDSC2; CTRP2 -0.2498 3.1222 -0.335 36.5711
YD-10B CTRP2 -0.1855 3.453 -0.3082 36.2592
HSC-3 GDSC1; GDSC2; CTRP2 0.159 3.5142 0.0511 33.9357
BICR 56 CTRP2 0.6766 6.4395 -0.1205 32.6793
BICR 22 GDSC1; GDSC2; CTRP2 0.775 7.4148 -0.3707 33.0643
PCI-06A GDSC2 0.9766 5.7051 -0.1303 29.1789
SCC-15 GDSC1; GDSC2 1.0092 7.4599 -0.8901 28.9701
SCC-25 GDSC1; GDSC2; CTRP2 1.0414 7.6299 -0.1707 31.6276
OSC-19 GDSC1; GDSC2 1.5431 4.8014 0.8436 19.1405
PCI-30 GDSC2 1.6393 5.2641 0.7434 21.8745
SCC-4 GDSC1; GDSC2; CTRP2 1.7989 5.9304 1.2682 24.5427
SNU-899 CTRP2 1.8682 5.8174 1.3806 23.9323
DOK GDSC2 2.012 6.6102 0.49 21.8081
PE/CA-PJ49 CTRP2 2.4317 6.3332 1.811 20.7035
FaDu GDSC2; CTRP2 2.5466 8.2559 1.1408 22.8596
BICR 16 CTRP2 2.583 9.525 0.6038 24.6513
PE/CA-PJ34 (clone C12) CTRP2 2.7177 6.4524 2.0725 18.9107
SNU-1066 CTRP2 2.9182 7.6154 1.8031 19.3859
PE/CA-PJ15 GDSC1; GDSC2; CTRP2 3.3191 8.8424 1.6495 18.9381
BHY GDSC1; GDSC2; CTRP2 3.4506 8.5173 1.9311 17.5177
BB49-HNC GDSC1; GDSC2 3.5804 7.3833 1.5024 9.4782
BICR 6 CTRP2 3.5905 10.5072 0.5063 23.3732
OSC-20 GDSC1; GDSC2 3.6126 10.3522 0.046 16.9176
BICR 31 GDSC2; CTRP2 3.7924 6.9419 2.995 12.4378
PE/CA-PJ41 (clone D2) CTRP2 3.7955 7.7351 2.6363 13.8636
BICR 18 CTRP2 4.1919 6.7616 3.4801 9.4881
SNU-1076 CTRP2 4.1983 7.6386 3.0755 11.1113
SCC-9 GDSC1; GDSC2; CTRP2; CTRP1 4.3609 9.239 2.4502 13.2978
SNU-46 CTRP2 4.5421 8.7976 2.8328 11.3289
YD-8 CTRP2 4.9769 8.113 3.5595 7.3837
SAT [Human HNSCC] GDSC2 5.4088 11.9744 0.587 11.5795
SNU-1041 CTRP2 6.3707 11.3269 3.0563 7.016
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
647V GDSC1; GDSC2 -2.7374 0.3452 -2.7743 53.395
UM-UC-3 GDSC1; GDSC2; CTRP2; CTRP1 -2.6493 0.5261 -2.6618 52.2353
639V GDSC1; GDSC2; CTRP2 -1.3756 1.2106 -1.3844 43.8136
CAL-29 GDSC1; GDSC2; CTRP2 -0.7034 3.9739 -0.9529 39.9806
VM-CUB-1 CTRP2 -0.6411 3.9848 -0.8876 39.5723
JMSU-1 CTRP2 -0.5822 2.2692 -0.6118 38.6059
5637 GDSC1; GDSC2; CTRP2; CTRP1 0.2758 9.3535 -1.6812 37.7952
RT-4 GDSC1; GDSC2; CTRP2; CTRP1 0.6191 4.4803 0.3785 31.3225
253J CTRP2 0.7042 4.1034 0.5446 30.4926
RT-112 GDSC1; GDSC2; CTRP2 1.1575 4.9068 0.8662 27.9369
U-BLC1 CTRP2 1.308 6.6809 0.4754 28.7769
SW780 GDSC1; GDSC2 1.5513 9.0769 -1.1378 27.9822
KU-19-19 GDSC2; CTRP2 2.1465 7.4779 1.0582 24.2741
253J-BV CTRP2 2.2354 6.8508 1.4042 22.7681
KMBC-2 CTRP2; CTRP1 2.2617 8.473 0.7534 28.618
BFTC-905 GDSC1; GDSC2; CTRP2 2.4238 8.3485 0.9743 23.7942
UM-UC-1 CTRP2 3.1146 7.0461 2.2511 17.1364
SW1710 GDSC1; GDSC2; CTRP2 3.7994 9.4341 1.8315 17.0618
HT-1376 GDSC1; GDSC2; CTRP2; CTRP1 4.01 7.118 3.1348 11.3292
TCCSUP GDSC1; GDSC2; CTRP2 4.1562 9.8936 1.9406 15.8069
T24 GDSC1; GDSC2; CTRP2 4.2128 8.4511 2.6981 12.6196
SCaBER CTRP2 4.7065 8.8714 2.9441 10.5144
BC-3C CTRP2 4.7461 8.9543 2.9382 10.455
HT-1197 GDSC1; GDSC2; CTRP2 5.1216 7.0809 4.1995 4.4095
J82 GDSC1; GDSC2; CTRP2 5.8994 13.6747 1.5372 13.8538
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
C-33 A GDSC1; GDSC2 -2.7907 1.2651 -2.9207 53.6314
SiSo GDSC1; GDSC2 -2.7621 1.6873 -2.9535 53.3038
SW954 GDSC1; GDSC2 -0.6081 4.1533 -1.2198 36.9815
PWR-1E GDSC1; GDSC2 -0.3294 8.1713 -2.5566 39.0738
PA-1 GDSC2 0.3194 5.9845 -0.931 35.4755
CAL-39 GDSC1; GDSC2 0.557 5.0142 -0.2813 28.241
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 0.6163 5.1083 -0.2564 27.8947
NT2-D1 GDSC1; GDSC2 0.6555 3.963 0.2147 25.5973
PEO1 GDSC2 0.7219 4.6196 0.0484 29.512
HEY GDSC2 0.7522 6.9918 -0.9314 33.4358
KGN GDSC1; GDSC2 0.8213 4.1632 0.3244 24.4186
HEC-1 GDSC1; GDSC2 1.0474 7.5694 -0.9036 28.881
OVCA433 GDSC2 1.1818 4.9982 0.3836 25.7456
BPH-1 GDSC1; GDSC2 1.8433 7.5799 -0.1371 22.9006
UWB1.289 GDSC2 1.9311 7.2259 0.117 24.0541
SKG-IIIa GDSC1; GDSC2 1.9412 6.9386 0.2647 20.6811
SKN GDSC2 2.0029 6.6533 0.4605 22.0011
HT-3 GDSC1; GDSC2 2.0658 10.0986 -1.1628 26.4089
NEC8 GDSC2 2.4478 4.5687 1.8758 12.0607
ME-180 GDSC1; GDSC2 2.7366 12.6792 -1.853 26.8092
Ca Ski GDSC1; GDSC2 2.7959 8.2125 0.4256 17.2677
JAR GDSC1; GDSC2 2.7968 5.2102 1.911 9.3173
TC-YIK GDSC1; GDSC2 2.8475 8.864 0.1462 18.4935
DSH1 GDSC1; GDSC2 2.8635 8.761 0.2115 18.1326
ACC-OV7 GDSC2 2.976 5.7919 1.788 10.7598
SW756 GDSC1; GDSC2 2.9868 9.5816 -0.0913 19.2229
SW962 GDSC1; GDSC2 3.1996 9.9399 -0.0896 18.6318
OVCA420 GDSC1; GDSC2 3.3636 9.8164 0.1093 17.2607
OV17R GDSC1; GDSC2 3.5526 5.9588 2.1904 5.7391
JHOS-3 GDSC1; GDSC2 3.9697 6.674 2.1503 5.0458
SiHa GDSC1; GDSC2 3.97 13.4185 -1.197 21.2942
LB831-BLC GDSC2 4.104 8.8711 1.1692 11.3654
NCC-IT GDSC2 4.1901 7.5861 1.8629 6.9844
JEG-3 GDSC2 4.431 7.3109 2.1587 4.6929
MS751 GDSC1; GDSC2 4.5249 11.464 0.2048 14.0013
DoTc2 4510 GDSC2 4.8442 10.0551 1.1241 9.8763
C-4-I GDSC2 4.9037 16.0751 -1.7891 23.0323
OVMIU GDSC1; GDSC2 5.4517 13.7079 -0.221 14.0017
HeLa GDSC1; GDSC2; CTRP2 6.1823 11.9659 2.6038 9.1554
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Drug discovery: Fresh target for cancer therapy. Nature. 2009 Apr 9;458(7239):709-10.
4 Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target.Cell Death Dis. 2017 Jun 1;8(6):e2834.
5 Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.Cell Death Dis.2012 Sep 6;3:e386.
6 The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-B activation and induces apoptosis in chronic lymphocytic leukemia B cells. Clin Cancer Res. 2014 Mar 15;20(6):1576-89. doi: 10.1158/1078-0432.CCR-13-0987.