Details of the Drug

General Information of Drug (ID: DMP78JY)

Drug Name
A-770041
Synonyms
A-770041; 869748-10-7; UNII-U9855G2ZPR; U9855G2ZPR; CHEMBL197603; KIN001-111; N-(4-{1-[4-(4-Acetylpiperazin-1-Yl)-Trans-Cyclohexyl]-4-Amino-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl}-2-Methoxyphenyl)-1-Methyl-1h-Indole-2-Carboxamide; A 770041; Kinome_3267; 2c0o; MLS006010241; CHEMBL1970879; SCHEMBL15705796; CHEBI:91457; MolPort-039-139-535; C34H39N9O3; 3413AH; ZINC14210723; BDBM50175196; ABP001109; AKOS030526954; ZINC253387967; CS-0057; NCGC00386613-01; NCGC00346955-01; SMR004701317; HY-11011; L2G; 1H-Indole-2-carboxamide, N-(4-(1-(trans-4-(4-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 621.7
Logarithm of the Partition Coefficient (xlogp) 3.3
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C34H39N9O3
IUPAC Name
N-[4-[1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methylindole-2-carboxamide
Canonical SMILES
CC(=O)N1CCN(CC1)C2CCC(CC2)N3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)NC(=O)C6=CC7=CC=CC=C7N6C)OC)N
InChI
InChI=1S/C34H39N9O3/c1-21(44)41-14-16-42(17-15-41)24-9-11-25(12-10-24)43-33-30(32(35)36-20-37-33)31(39-43)23-8-13-26(29(19-23)46-3)38-34(45)28-18-22-6-4-5-7-27(22)40(28)2/h4-8,13,18-20,24-25H,9-12,14-17H2,1-3H3,(H,38,45)(H2,35,36,37)
InChIKey
ZMNWFTYYYCSSTF-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9549184
ChEBI ID
CHEBI:91457
CAS Number
869748-10-7
TTD ID
D06WGX
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
LCK tyrosine protein kinase (LCK) TT860QF LCK_HUMAN Inhibitor [1]
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
LCK tyrosine protein kinase (LCK) DTT LCK 4.46E-02 -0.13 -1.09
Proto-oncogene c-Src (SRC) DTT SRC 7.46E-03 -0.2 -1.24
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 143 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 3.2468 5.9627 1.2302 6.1135
CTV-1 GDSC1 -7.139 -4.7329 -7.1394 96.8901
GA-10 GDSC1 -5.4327 -3.0001 -5.4346 89.037
SU-DHL-4 GDSC1 -5.3839 -3.4407 -5.3842 90.5954
SU-DHL-6 GDSC1 -5.2502 -3.8928 -5.2502 91.8019
DoHH2 GDSC1 -4.6224 -1.0441 -4.6666 78.7989
NU-DUL-1 GDSC1 -3.4892 -1.4116 -3.4931 71.9392
SU-DHL-16 GDSC1 -2.8509 -0.4971 -2.8673 64.2382
LAMA-84 GDSC1 -2.7987 0.3397 -2.8741 62.6295
ALL-SIL GDSC1 -2.773 -0.687 -2.7815 63.6038
Farage GDSC1 -2.1965 1.9948 -2.5184 55.3817
Karpas-231 GDSC1 -2.0944 3.803 -2.9607 53.5555
MY-M12 GDSC1 -2.041 1.1764 -2.1796 54.3511
SUP-B15 GDSC1 -1.5749 2.3739 -1.9388 49.3061
EM-2 GDSC1 -1.3811 3.0619 -1.9348 47.5149
BV-173 GDSC1 -1.3382 1.8717 -1.5544 46.6462
K-562 GDSC1 -1.1585 2.0341 -1.3965 44.6708
MC116 GDSC1 -0.7501 5.9389 -2.4027 43.5918
MLMA GDSC1 -0.5515 7.0086 -2.685 42.8938
BL-41 GDSC1 -0.5265 7.712 -2.9863 43.2228
KCL-22 GDSC1 -0.3048 2.493 -0.5863 34.8798
P32/ISH GDSC1 -0.0363 3.213 -0.5303 32.8378
WIL2 NS GDSC1 0.1222 3.5103 -0.4716 31.538
Daudi GDSC1 0.2133 10.6131 -3.6705 40.8343
NALM-6 GDSC1 0.27 2.2765 0.1007 27.1662
LP-1 GDSC1 0.6268 1.3545 0.6232 21.6393
HDLM-2 GDSC1 0.6544 2.3653 0.4965 22.3058
MEG-01 GDSC1 0.6694 7.0454 -1.5089 33.2948
SU-DHL-8 GDSC1 0.7411 7.2636 -1.546 33.0851
697 GDSC1 0.747 4.5338 -0.2528 26.7347
NK-92MI GDSC1 0.8767 3.2124 0.4476 21.4144
HC-1 GDSC1 0.9393 4.5635 -0.0729 24.6146
VL51 GDSC1 0.988 4.7262 -0.0994 24.5391
Namalwa GDSC1 1.023 9.1856 -2.2246 34.124
NB4 GDSC1 1.1299 1.6825 1.1261 15.3522
MHH-PREB-1 GDSC1 1.167 8.1285 -1.5725 31.2121
QIMR-WIL GDSC1 1.3355 8.5643 -1.6348 30.7215
Jiyoye GDSC1 1.4104 6.3624 -0.481 24.8486
KY821 GDSC1 1.4973 5.9627 -0.2048 22.7937
Hs 445 GDSC1 1.5968 6.2285 -0.2443 22.5997
Karpas-620 GDSC1 1.6735 2.4117 1.5953 9.0502
MV4-11 GDSC1 1.6793 2.4246 1.5977 9.0011
SR GDSC1 1.6974 2.425 1.6174 8.7645
KOPN-8 GDSC1 1.8311 6.968 -0.4008 22.5515
MOLT-13 GDSC1 1.838 2.4263 1.7701 6.9276
Karpas-299 GDSC1 1.8665 2.3925 1.8114 6.4851
EHEB GDSC1 1.8682 11.048 -2.4028 31.334
Ku812 GDSC1 1.8814 12.3554 -3.0444 33.1693
Ramos.2G6.4C10 GDSC1 1.8893 9.9923 -1.8576 29.3418
SIG-M5 GDSC1 1.8948 3.4677 1.381 9.5422
EoL-1 GDSC1 2.0611 6.7744 -0.1034 19.765
ML-2 GDSC1 2.3329 3.8057 1.6119 5.9541
Karpas-45 GDSC1 2.3362 14.3325 -3.6487 33.1989
OCI-AML-2 GDSC1 2.3504 4.166 1.4464 7.195
HT GDSC1 2.3599 3.0876 1.9935 2.8461
HL-60 GDSC1 2.3807 3.3589 1.8751 3.7057
KE-37 GDSC1 2.3963 3.515 1.8099 4.165
DEL GDSC1 2.6917 4.6349 1.4829 5.7627
Loucy GDSC1 2.7011 5.2647 1.1784 8.1001
H9 GDSC1 2.7495 5.3203 1.1877 7.8739
RPMI-6666 GDSC1 2.7778 9.8198 -1.0304 22.4257
ALL-PO GDSC1 2.838 7.6118 0.1183 15.4373
ST486 GDSC1 2.8677 5.2207 1.3246 6.4548
ARH-77 GDSC1 2.869 13.3184 -2.7037 28.9079
JJN-3 GDSC1 2.9913 4.6385 1.6909 3.3425
HEL GDSC1 3.0667 4.8799 1.6259 3.6365
BALL-1 GDSC1 3.2017 13.1695 -2.3631 26.7231
SUP-M2 GDSC1 3.2193 4.7863 1.7627 2.326
CCRF-CEM GDSC1 3.2528 6.499 0.976 7.9898
A3/Kawakami GDSC1 3.2657 4.5691 1.8842 1.4489
RS4;11 GDSC1 3.2661 5.7567 1.3413 5.2404
BE-13 GDSC1 3.2673 12.8765 -2.1653 25.7958
SCC-3 GDSC1 3.3999 4.9244 1.8021 1.7401
SK-MM-2 GDSC1 3.4414 5.8473 1.4108 4.3169
RPMI-8866 GDSC1 3.5028 7.6964 0.5707 10.2339
P31/FUJ GDSC1 3.5205 5.0294 1.8198 1.4464
ME1 GDSC1 3.5244 6.4758 1.1695 5.8588
GDM-1 GDSC1 3.5749 6.8449 1.028 6.7575
AMO1 GDSC1 3.5779 5.0031 1.859 1.1476
KMS-12-BM GDSC1 3.5912 5.6263 1.5995 2.7081
SUP-T1 GDSC1 3.5945 5.9819 1.4418 3.767
HH [Human lymphoma] GDSC1 3.5969 13.9189 -2.4265 25.7711
OPM-2 GDSC1 3.6205 6.7155 1.1185 5.9949
HAL-01 GDSC1 3.6439 8.893 0.0888 13.1165
Mono-Mac-6 GDSC1 3.6486 6.4079 1.2793 4.786
CESS GDSC1 3.6654 8.3516 0.367 11.196
MN-60 GDSC1 3.6825 5.8765 1.5398 2.9326
OCI-AML-5 GDSC1 3.7011 7.9884 0.5667 9.7188
JSC-1 GDSC1 3.7144 5.462 1.7358 1.6561
ATN-1 GDSC1 3.7567 6.5925 1.2601 4.6843
U-698-M GDSC1 3.7752 6.619 1.2591 4.652
MOLM-13 GDSC1 3.7979 11.1357 -0.8977 18.4893
SKM-1 GDSC1 3.814 5.0227 1.9557 0.4693
OCI-Ly19 GDSC1 3.8191 7.3251 0.9593 6.6553
Raji GDSC1 3.8419 9.9297 -0.2752 14.8398
WSU-DLCL2 GDSC1 3.8725 4.9448 2.0071 0.267
BC-1 GDSC1 3.8884 6.0246 1.5866 2.284
JVM-2 GDSC1 3.9516 10.1765 -0.3174 14.7836
BC-3 GDSC1 3.9814 6.4442 1.4549 2.9499
U266B1 GDSC1 3.9962 8.9761 0.293 10.8025
L-1236 GDSC1 4.0037 7.9569 0.7809 7.4655
OCI-M1 GDSC1 4.0406 5.4319 1.8954 0.5352
WSU-NHL GDSC1 4.0578 5.9879 1.6861 1.4782
KMOE-2 GDSC1 4.0922 6.4957 1.4914 2.5426
Granta-519 GDSC1 4.1587 8.0323 0.8426 6.6865
JVM-3 GDSC1 4.1856 5.8792 1.7868 0.8583
A4/Fukuda GDSC1 4.1941 5.7096 1.8545 0.5802
YT GDSC1 4.2435 5.674 1.8872 0.4363
IM-9 GDSC1 4.2576 5.6846 1.8888 0.4233
RL GDSC1 4.3085 9.0196 0.477 8.8045
SUP-HD1 GDSC1 4.4071 6.5184 1.6349 1.3427
CTB-1 GDSC1 4.4156 16.114 -2.891 25.1271
MOLT-16 GDSC1 4.4306 5.8012 1.9126 0.2755
Kasumi-1 GDSC1 4.4563 6.65 1.605 1.4362
L-540 GDSC1 4.4652 6.3322 1.7324 0.8524
EJM GDSC1 4.4863 6.2672 1.7656 0.7064
TUR GDSC1 4.5194 6.0165 1.8698 0.3487
PF-382 GDSC1 4.5932 24.3847 -6.8539 33.5886
DB GDSC1 4.597 6.2536 1.8145 0.4705
OCI-AML-3 GDSC1 4.6205 5.9908 1.9157 0.2038
CA46 GDSC1 4.6412 12.7887 -1.1004 17.2057
THP-1 GDSC1 4.6593 6.8222 1.6275 1.1316
KG-1 GDSC1 4.6889 6.3316 1.8216 0.4037
DND-41 GDSC1 4.7341 10.8313 -0.1014 11.4576
NOMO-1 GDSC1 4.782 12.979 -1.0948 16.8174
RPMI-8402 GDSC1 4.8747 15.2298 -2.1216 21.1651
DG-75 GDSC1 4.9414 14.206 -1.5771 18.6981
EB2 GDSC1 5.0132 13.9098 -1.3842 17.6362
RPMI-8226 GDSC1 5.0295 12.4795 -0.6885 14.0989
GR-ST GDSC1 5.0853 9.639 0.659 6.0051
Karpas-422 GDSC1 5.147 13.9792 -1.3262 17.0365
NKM-1 GDSC1 5.1491 7.114 1.7168 0.4814
LC4-1 GDSC1 5.1868 18.4192 -3.4559 25.0152
L-428 GDSC1 5.2305 12.1558 -0.4055 12.0739
MOLT-4 GDSC1 5.3791 18.8414 -3.5231 24.7737
PL-21 GDSC1 5.5758 12.0118 -0.1255 9.7423
KM-H2 GDSC1 5.6297 12.012 -0.0934 9.4493
P30/OHK GDSC1 5.7512 14.9229 -1.373 15.8514
Reh GDSC1 5.9357 15.5935 -1.5698 16.338
SU-DHL-1 GDSC1 5.9629 16.0275 -1.7578 17.1006
L-363 GDSC1 6.1688 15.1282 -1.201 14.1407
ROS-50 GDSC1 6.3043 13.0784 -0.1819 8.658
MOLP-8 GDSC1 6.9269 20.8382 -3.4091 21.154
⏷ Show the Full List of 143 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1 -1.1289 5.5037 -2.6045 46.2719
HCE-4 GDSC1 0.8807 6.4221 -1.0074 30.1156
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 4.3605 7.1596 1.3475 2.9942
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GI-ME-N GDSC1 0.1076 9.0561 -3.0127 40.1573
KP-N-YS GDSC1 1.0926 2.4788 0.9419 16.7922
IMR-5 GDSC1 1.3243 6.1894 -0.4761 25.2131
NB69 GDSC1 1.6079 5.8653 -0.0553 21.3465
TGW GDSC1 1.7556 2.8699 1.5134 9.1995
SiMa GDSC1 2.1806 6.452 0.1601 17.5351
GOTO GDSC1 2.9733 8.7003 -0.3175 17.7812
MHH-NB-11 GDSC1 3.3423 6.3571 1.1058 6.785
SJNB-13 GDSC1 3.3479 6.624 0.9815 7.6874
SK-N-DZ GDSC1 3.4258 7.9592 0.3883 11.7326
NB(TU)1 GDSC1 3.4436 6.8355 0.9451 7.698
SK-N-FI GDSC1 3.4823 5.9536 1.3868 4.3952
SJNB-17 GDSC1 3.6724 7.4132 0.8225 7.9875
CHP-126 GDSC1 3.7547 7.1291 1.0102 6.4482
KP-N-RT-BM-1 GDSC1 3.8667 9.3673 0.0157 12.9592
SJNB-7 GDSC1 3.8812 8.7168 0.3396 10.795
SJNB-5 GDSC1 4.1739 9.9166 -0.0375 12.4668
Kelly GDSC1 4.3194 6.2258 1.7107 1.0735
SJNB-6 GDSC1 4.3806 6.1056 1.7827 0.7176
KP-N-YN GDSC1 4.8373 16.2467 -2.6455 23.2215
SK-N-BE(2)-M17 GDSC1 4.8851 6.4117 1.8655 0.2251
SJNB-14 GDSC1 4.9524 6.2815 1.9327 0.1027
NH-12 GDSC1 4.9645 6.7896 1.7626 0.4399
SJNB-10 GDSC1 5.2731 6.9973 1.8027 0.2355
LA-N-6 GDSC1 5.5244 13.9339 -1.0532 14.828
NB1 GDSC1 5.7987 10.3005 0.7535 4.28
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NOS-1 [Human HNSCC] GDSC1 -2.2161 2.0894 -2.5634 55.493
ES6 GDSC1 0.3673 10.4967 -3.4708 39.8638
EW-16 GDSC1 1.4647 9.7168 -2.0911 31.8537
ES8 GDSC1 2.2913 9.4373 -1.2386 25.1885
EW-24 GDSC1 2.9521 5.085 1.4508 5.2474
EW-12 GDSC1 4.1544 7.24 1.2 4.2885
ES1 GDSC1 4.1564 6.2685 1.6187 1.7173
EW-1 GDSC1 4.2375 6.8523 1.4147 2.78
EW-13 GDSC1 4.3225 6.3826 1.6504 1.3573
SK-ES-1 GDSC1 4.3747 6.0131 1.8148 0.602
SK-PN-DW GDSC1 4.3905 6.7726 1.5247 1.9295
ES4 GDSC1 4.4135 7.1549 1.3768 2.7374
SJSA-1 GDSC1 4.4151 11.0666 -0.4256 14.1674
EW-11 GDSC1 4.431 7.2445 1.3478 2.8828
ES7 GDSC1 4.6901 10.7251 -0.0798 11.4324
EW-18 GDSC1 4.8459 7.3131 1.5183 1.4498
H-EMC-SS GDSC1 4.8579 7.3395 1.5133 1.4613
TC-71 GDSC1 5.0904 6.9369 1.7576 0.3981
ES5 GDSC1 5.6546 8.0312 1.5811 0.6255
EW-3 GDSC1 5.9729 8.0579 1.688 0.2594
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 GDSC1 1.6373 5.6484 0.0783 20.33
OCUB-M GDSC1 2.1071 7.1214 -0.237 20.4318
HCC2218 GDSC1 2.4655 13.8724 -3.3111 31.9464
MRK-nu-1 GDSC1 2.5834 4.7098 1.363 7.0451
Evsa-T GDSC1 3.0695 7.8557 0.1759 14.2838
BT-474 GDSC1 4.0369 10.2828 -0.3089 14.4954
COLO 824 GDSC1 4.0648 9.156 0.2532 10.8874
CAL-148 GDSC1 4.0674 5.5085 1.8778 0.5823
HCC1599 GDSC1 4.1134 7.5077 1.0557 5.3352
HCC2157 GDSC1 4.367 6.2799 1.7105 1.03
HCC1187 GDSC1 4.5845 10.2712 0.0659 10.7914
MFM-223 GDSC1 5.1774 6.5928 1.9056 0.1003
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-336MG GDSC1 -1.9613 1.3245 -2.1194 53.4537
GB-1 GDSC1 -1.8922 2.6101 -2.352 52.3315
SNB-75 GDSC1 -1.537 6.4073 -3.4158 49.3283
NMC-G1 GDSC1 -0.8686 7.3452 -3.1564 45.2723
KS-1 [Human Krukenberg tumour] GDSC1 -0.0862 5.6171 -1.5837 37.6147
Becker GDSC1 0.343 7.354 -1.9696 36.4975
GI-1 GDSC1 0.3673 3.4647 -0.1928 28.4606
8-MG-BA GDSC1 0.9384 5.3405 -0.4358 26.8351
Onda 10 GDSC1 1.0073 11.294 -3.2813 36.9375
KALS-1 GDSC1 1.2332 7.198 -1.0543 28.6679
SF268 GDSC1 1.8327 6.3368 -0.0856 20.5811
KINGS-1 GDSC1 2.285 8.6706 -0.8606 23.3287
D-247MG GDSC1 2.3223 7.4535 -0.2208 19.4982
ONS-76 GDSC1 2.7797 4.0685 1.8221 2.9023
D283 Med GDSC1 3.7852 8.3326 0.4587 10.2422
D-263MG GDSC1 3.9102 11.8717 -1.1768 19.5835
D-502MG GDSC1 4.1669 6.9272 1.3449 3.3283
AM-38 GDSC1 4.3364 6.2074 1.7253 0.9925
Onda 11 GDSC1 4.4875 11.3644 -0.5193 14.5148
KNS-81-FD GDSC1 4.6741 6.3893 1.7953 0.4884
SF126 GDSC1 5.0409 18.0274 -3.3702 25.0987
SF539 GDSC1 5.1312 11.7695 -0.2877 11.6306
U-87MG ATCC GDSC1 5.9903 13.1709 -0.4066 10.47
CAS-1 GDSC1 6.2239 19.9813 -3.4783 22.7954
KNS-42 GDSC1 6.7992 21.7967 -3.9568 23.0355
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -1.4248 3.512 -2.135 48.0528
TGBC24TKB GDSC1 -0.1409 3.8306 -0.8767 35.2255
TGBC1TKB GDSC1 0.8151 2.5659 0.6128 20.6047
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 -1.3422 2.6699 -1.7698 46.9903
KLE GDSC1 0.5164 13.6183 -4.8731 41.3525
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB996-RCC GDSC1 -3.5362 -1.4874 -3.5396 72.5193
LB1047-RCC GDSC1 -2.9538 0.597 -3.0704 63.615
OS-RC-2 GDSC1 -0.9558 5.3318 -2.3515 44.8236
TK-10 GDSC1 -0.7468 1.621 -0.8615 39.3803
RXF 393L GDSC1 -0.1262 4.6693 -1.2076 36.5224
HA7-RCC GDSC1 -0.0039 3.4362 -0.578 32.8891
A-704 GDSC1 0.1687 5.3155 -1.19 34.6981
BB65-RCC GDSC1 1.9183 5.0784 0.6149 15.3118
RCC10RGB GDSC1 3.2942 11.8251 -1.6211 23.5025
LB2241-RCC GDSC1 3.3772 9.6205 -0.4642 17.3533
A-498 GDSC1 4.0608 5.7174 1.7952 0.9345
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H747 GDSC1 1.0898 7.2538 -1.2142 30.0626
RKO GDSC1 1.6868 7.1845 -0.6362 24.5138
C2BBe1 GDSC1 1.9425 7.2695 -0.4532 22.4038
LS123 GDSC1 2.4916 10.0116 -1.3593 25.0178
COLO 320HSR GDSC1 2.7557 5.7594 0.975 9.4919
SNU-C2B GDSC1 2.8465 11.2652 -1.6966 25.2733
LS1034 GDSC1 3.2368 8.3291 0.0681 14.475
MDST8 GDSC1 3.6692 6.4239 1.2845 4.7039
LS411N GDSC1 3.8107 10.5082 -0.5804 16.7179
KM12 GDSC1 4.1083 6.684 1.419 2.9618
CL-11 GDSC1 4.3466 6.6674 1.5467 1.8661
LS513 GDSC1 4.6828 11.0007 -0.2148 12.2592
NCI-H716 GDSC1 4.7964 7.6587 1.3568 2.3217
SNU-C1 GDSC1 5.0192 6.9869 1.7128 0.558
CW-2 GDSC1 5.3401 7.2311 1.7463 0.3306
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 4.5782 6.2368 1.8133 0.4844
Cancer Drug Sensitivity Data Curated from 63 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1975 GDSC1 -1.671 1.8271 -1.9065 50.2889
NCI-H1648 GDSC1 -1.301 3.3848 -1.9567 46.8566
HOP-62 GDSC1 -1.1319 2.4501 -1.4765 44.6266
LC-2/ad GDSC1 -0.9425 1.2571 -1.0141 41.5751
LXF 289 GDSC1 -0.2923 3.0786 -0.7593 35.6685
NCI-H1436 GDSC1 1.265 6.2437 -0.558 25.9534
NCI-H510A GDSC1 1.5965 5.6815 0.0245 20.8701
LB647-SCLC GDSC1 1.6351 5.1863 0.3029 18.7859
NCI-H720 GDSC1 1.7264 2.3087 1.6812 8.1664
NCI-H211 GDSC1 1.9973 7.2087 -0.3754 21.7187
Ms-1 GDSC1 2.1016 3.0515 1.7788 5.568
SHP-77 GDSC1 2.1406 8.173 -0.7338 23.2036
IA-LM GDSC1 2.3301 6.5201 0.2524 16.325
NCI-H2141 GDSC1 2.4871 4.3504 1.4659 6.5599
NCI-H1304 GDSC1 2.7102 4.0074 1.8038 3.229
NCI-H1869 GDSC1 3.0565 7.3065 0.4376 12.5087
Calu-6 GDSC1 3.1953 6.3997 0.9839 8.0927
NCI-H1963 GDSC1 3.2585 5.8712 1.2818 5.6998
NCI-H1876 GDSC1 3.2871 5.3946 1.5249 3.8506
NCI-H69 GDSC1 3.458 6.2756 1.221 5.6471
IST-SL1 GDSC1 3.4924 7.4198 0.6973 9.3609
IST-SL2 GDSC1 3.5529 10.7149 -0.8726 19.0893
NCI-H1836 GDSC1 3.5677 6.4059 1.2299 5.3207
COR-L88 GDSC1 3.5717 7.5175 0.7048 9.0919
NCI-H2196 GDSC1 3.5991 8.1909 0.3985 11.1651
NCI-H1694 GDSC1 3.6232 5.1344 1.827 1.2646
Lu-165 GDSC1 3.6435 7.7611 0.6367 9.3823
NCI-H847 GDSC1 3.6742 5.3535 1.7612 1.5668
COR-L95 GDSC1 3.7122 10.2431 -0.5222 16.6736
NCI-H64 GDSC1 3.7478 4.9846 1.9427 0.5699
NCI-H1355 GDSC1 3.7966 12.3077 -1.4761 21.3339
NCI-H748 GDSC1 3.8377 6.5745 1.3163 4.13
NCI-H1155 GDSC1 3.8442 6.0648 1.5459 2.6078
CPC-N GDSC1 3.9264 6.5468 1.3795 3.5351
NCI-H2081 GDSC1 3.9405 5.8937 1.6682 1.7275
DMS 79 GDSC1 3.967 6.9295 1.2315 4.444
NCI-H2171 GDSC1 3.9728 5.5332 1.8284 0.8673
NCI-H23 GDSC1 4.0935 8.3044 0.6752 7.9789
NCI-H226 GDSC1 4.1189 11.2391 -0.7158 16.5962
NCI-H82 GDSC1 4.185 5.6406 1.8763 0.5079
NCI-H526 GDSC1 4.1896 5.6078 1.8902 0.4579
NCI-H1092 GDSC1 4.2157 6.5541 1.5295 2.1356
Lu-139 GDSC1 4.3027 6.7057 1.5096 2.129
NCI-H2135 GDSC1 4.3028 5.8846 1.8334 0.5831
DMS 114 GDSC1 4.3114 6.0771 1.7646 0.8451
COLO 668 GDSC1 4.3234 9.8523 0.0935 11.2579
EKVX GDSC1 4.3446 13.7724 -1.7915 21.1859
NCI-H1581 GDSC1 4.3722 5.8458 1.8749 0.4049
NCI-H1838 GDSC1 4.4271 9.4104 0.3694 9.2325
SBC-1 GDSC1 4.5133 5.9847 1.8787 0.3275
NCI-H524 GDSC1 4.5803 6.3312 1.7797 0.5931
Lu-134-A GDSC1 4.7899 9.37 0.6099 6.8844
NCI-H1770 GDSC1 4.8307 11.5217 -0.3648 12.776
NCI-H1650 GDSC1 4.851 7.1655 1.5778 1.1779
HCC33 GDSC1 4.8702 6.1658 1.9433 0.103
NCI-H209 GDSC1 4.8798 6.7086 1.7594 0.4898
NCI-H1666 GDSC1 4.9515 7.0188 1.6746 0.7227
NCI-H322M GDSC1 5.6001 16.1817 -2.0756 19.2396
NCI-H446 GDSC1 5.8695 22.9 -5.1552 27.8921
NCI-H345 GDSC1 5.928 17.3017 -2.3902 19.7289
NCI-H187 GDSC1 6.2533 15.6943 -1.4122 14.9469
Lu-65 GDSC1 6.5042 17.0859 -1.9052 16.5722
NCI-H128 GDSC1 6.9893 16.1336 -1.1614 12.3346
⏷ Show the Full List of 63 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 3.2021 13.0514 -2.3039 26.5088
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-8 GDSC1 -1.9283 2.5825 -2.3833 52.6669
TE-15 GDSC1 -1.7114 1.5707 -1.8958 50.7358
TE-10 GDSC1 0.3369 3.2477 -0.1421 28.3227
TE-11 GDSC1 0.5734 3.4976 0.0127 26.0003
TE-1 GDSC1 1.2101 8.0856 -1.512 30.7795
TE-5 GDSC1 2.9691 5.9675 1.0323 8.3889
TE-6 GDSC1 3.6184 10.0982 -0.5199 16.9395
EC-GI-10 GDSC1 4.255 5.9558 1.787 0.7987
TE-9 GDSC1 4.271 9.765 0.1003 11.3468
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OVCAR-4 GDSC1 -0.1934 8.1959 -2.8887 41.3654
Kuramochi GDSC1 -0.1899 5.8985 -1.8155 38.9257
ES-2 GDSC1 4.2146 5.736 1.8529 0.5718
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-PC-1 GDSC1 -0.8738 2.5813 -1.2327 41.8208
PSN1 GDSC1 0.0921 2.7353 -0.2278 30.3052
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 -0.2542 2.0474 -0.4147 33.5947
MPP 89 GDSC1 2.1868 6.1914 0.2956 16.5665
MSTO-211H GDSC1 4.0593 7.2747 1.1295 4.9473
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 3.8816 6.3047 1.4615 3.082
LNCaP clone FGC GDSC1 4.1482 7.6928 0.9921 5.6934
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 3.7321 5.8482 1.5796 2.5851
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH-4 GDSC1 -0.2055 5.4963 -1.6506 38.5319
IST-MEL1 GDSC1 -0.1226 8.2085 -2.8262 40.9003
A101D GDSC1 1.1639 5.8707 -0.4722 25.942
LOX-IMVI GDSC1 1.2348 3.9694 0.4948 19.2579
A-388 GDSC1 1.6074 6.1902 -0.2158 22.3754
GAK GDSC1 3.0165 7.9178 0.1047 14.9358
SK-MEL-1 GDSC1 3.2933 7.5092 0.5127 11.2493
MMAc-SF GDSC1 3.4051 10.7978 -1.0255 20.3409
SK-MEL-2 GDSC1 3.6512 12.1019 -1.484 21.7995
MZ-MEL-7 GDSC1 3.6518 8.7801 0.1495 12.6956
CP66-MEL GDSC1 3.9293 6.43 1.4327 3.1832
CP67-MEL GDSC1 4.0123 11.5672 -0.9527 18.1582
LB373-MEL-D GDSC1 4.4034 13.6218 -1.675 20.5244
UACC-257 GDSC1 4.5779 8.9129 0.6921 6.7887
DJM-1 GDSC1 4.627 6.5532 1.7162 0.7923
MZ-MEL-2 GDSC1 4.7411 13.9846 -1.6103 19.353
HT-144 GDSC1 5.5497 19.2987 -3.6236 24.6862
LB2518-MEL GDSC1 5.8064 14.9565 -1.3528 15.6346
COLO 829 GDSC1 5.8891 20.7847 -4.1055 25.2992
COLO 800 GDSC1 6.2934 13.8257 -0.5245 10.5052
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 0.4315 3.7267 -0.2298 28.3194
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW982 GDSC1 -1.4147 3.7247 -2.1999 48.0135
SW872 GDSC1 -1.1667 3.5198 -1.859 45.6293
MFH-ino GDSC1 -0.0116 5.2561 -1.3463 36.3534
SK-LMS-1 GDSC1 1.8969 2.4163 1.8373 6.136
TE 441.T GDSC1 1.9051 2.8842 1.6617 7.3648
SK-UT-1 GDSC1 3.9937 11.0999 -0.7375 17.0663
EW-8 GDSC1 4.2911 6.3921 1.6322 1.4834
VA-ES-BJ GDSC1 4.5412 13.7417 -1.6343 19.9792
SW684 GDSC1 4.9558 15.3844 -2.1391 21.0322
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GCIY GDSC1 1.306 6.2897 -0.5422 25.675
RF-48 GDSC1 2.3072 6.4872 0.2497 16.4296
SNU-16 GDSC1 3.5506 9.6352 -0.3422 16.0976
HSC-39 GDSC1 3.5612 5.61 1.5899 2.8275
SNU-1 GDSC1 3.9266 11.026 -0.7498 17.3242
SNU-5 GDSC1 4.3118 6.0842 1.7621 0.8554
SCH GDSC1 4.3432 6.1264 1.7592 0.8411
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC1 2.7212 8.105 -0.22 18.0417
CGTH-W-1 GDSC1 3.9643 7.1182 1.1443 5.0429
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB30-HNC GDSC1 -0.1079 3.3421 -0.6545 33.9432
BB49-HNC GDSC1 2.5552 5.0861 1.1533 8.7778
LB771-HNC GDSC1 2.7597 9.0363 -0.6538 20.4808
SCC-15 GDSC1 5.3143 18.1916 -3.2521 24.0962
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB831-BLC GDSC1 -0.5918 2.7688 -0.9825 38.7569
KGN GDSC1 -0.4578 3.5101 -1.0923 38.2437
SW954 GDSC1 0.2002 5.0044 -1.0185 33.789
NEC8 GDSC1 0.6063 1.7331 0.5736 22.0806
NT2-D1 GDSC1 2.2319 4.8048 1.0268 10.9256
SW962 GDSC1 2.6698 7.0405 0.2699 14.9745
NCC-IT GDSC1 2.8519 6.1641 0.8479 10.149
DSH1 GDSC1 2.8555 4.4681 1.6818 3.7591
JAR GDSC1 3.8256 7.5048 0.8792 7.2044
OMC-1 [Human cervical carcinoma] GDSC1 4.2942 6.3053 1.6683 1.2997
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

1 Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection. Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22.