Details of the Drug

General Information of Drug (ID: DMP8HW1)

Drug Name
LY2157299
Synonyms
Galunisertib; 700874-72-2; LY2157299; LY 2157299; LY-2157299; UNII-3OKH1W5LZE; 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide; 3OKH1W5LZE; Galunisertib (LY2157299); AK-79916; 4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide; 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo-[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide; 4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
Indication
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Phase 2/3 [1]
Non-small-cell lung cancer 2C25.Y Phase 2/3 [2]
Hepatocellular carcinoma 2C12.02 Phase 2 [2]
Glioma 2A00.0 Phase 1/2 [3]
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [2]
Pancreatic cancer 2C10 Phase 1 [2]
⏷ Show the Full List of Indication(s)
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 369.4
Logarithm of the Partition Coefficient (xlogp) 2.4
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C22H19N5O
IUPAC Name
4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
Canonical SMILES
CC1=NC(=CC=C1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N
InChI
InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)
InChIKey
IVRXNBXKWIJUQB-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
10090485
ChEBI ID
CHEBI:137064
CAS Number
700874-72-2
UNII
3OKH1W5LZE
DrugBank ID
DB11911
TTD ID
D06TFI
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TGF-beta receptor type I (TGFBR1) TTP4520 TGFR1_HUMAN Modulator [4]
Transforming growth factor beta 1 (TGFB1) TTR9XHZ TGFB1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Arteriosclerosis
ICD Disease Classification BD40
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Transforming growth factor beta 1 (TGFB1) DTT TGFB1 5.95E-09 1.68 7.81
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MHH-NB-11 CTRP2 8.4144 10.2892 5.4268 0.343
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 CTRP2 6.9504 9.0905 5.1939 2.1578
SNU-1196 CTRP2 7.4738 8.8667 5.5726 0.4213
SNU-478 CTRP2 7.9075 9.3902 5.5557 0.2756
SNU-245 CTRP2 7.9695 10.1759 5.2771 0.9177
SNU-308 CTRP2 8.3574 9.6254 5.6392 0.0692
SNU-1079 CTRP2 8.5051 10.4341 5.4096 0.3444
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CADO-ES1 CTRP2 6.2561 8.2162 5.1295 3.4561
SW1353 CTRP2 7.3025 9.6947 5.1305 1.9857
U2OS CTRP2 8.0491 10.2159 5.2983 0.8086
MHH-ES-1 CTRP2 12.2405 24.7049 1.2326 10.044
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KPL-1 CTRP2 6.1171 8.575 4.8391 4.9276
MCF-7 CTRP2 6.9893 9.4021 5.0726 2.5803
CAMA-1 CTRP2 7.0693 9.3716 5.1376 2.2281
HCC1954 CTRP2 7.2357 9.7242 5.0771 2.2603
HMC-1-8 CTRP2 7.4178 8.5657 5.6637 0.2426
HCC1806 CTRP2 7.5642 10.4705 4.933 2.426
CAL-120 CTRP2 8.016 9.1998 5.664 0.0913
CAL-51 CTRP2 8.1712 9.7359 5.533 0.2336
JIMT-1 CTRP2 8.4085 9.6841 5.637 0.0654
HDQ-P1 CTRP2 8.4264 10.2484 5.4465 0.3039
HCC1395 CTRP2 8.5815 10.3538 5.4681 0.2265
HCC1937 CTRP2 8.7811 10.3114 5.5548 0.0903
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 7.0799 10.9412 4.3961 5.1656
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-489 CTRP2 6.9765 8.3823 5.5304 0.8927
LN-18 CTRP2 7.1816 8.2136 5.6984 0.2662
NMC-G1 CTRP2 7.35 8.9728 5.472 0.7756
CAS-1 CTRP2 7.5243 9.036 5.5286 0.5046
SNU-626 CTRP2 7.6515 8.8769 5.6424 0.2026
SNU-1105 CTRP2 7.6983 8.7343 5.7106 0.0927
GB-1 CTRP2 7.7183 12.7029 3.9857 5.8964
SNU-738 CTRP2 7.8192 9.2135 5.5855 0.2503
SF126 CTRP2 7.8554 10.6192 5.0317 1.7822
U-87MG ATCC CTRP2 7.9795 9.2098 5.6475 0.1159
ONS-76 CTRP2 8.0171 9.5329 5.5467 0.2561
LN-229 CTRP2 8.2897 9.8507 5.5371 0.1966
Daoy CTRP2 8.3005 9.6373 5.6153 0.0982
SNU-201 CTRP2 9.4625 21.7009 0.8493 14.7224
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-1-B CTRP2 7.2126 8.8701 5.4453 0.9685
HEC-251 CTRP2 7.3844 9.0308 5.4648 0.772
HEC-265 CTRP2 7.4915 8.7177 5.6371 0.2682
HEC-59 CTRP2 7.656 9.1121 5.5566 0.3718
RL95-2 CTRP2 8.1723 9.5269 5.6074 0.1281
HEC-6 CTRP2 8.4497 9.638 5.6664 0.0419
JHUEM-2 CTRP2 8.8268 10.3076 5.5718 0.0718
HEC-108 CTRP2 12.1443 20.8572 2.8913 5.0109
Ishikawa (Heraklio) 02 ER- CTRP2 6.9859 9.4441 5.0506 2.6712
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Ku812 CTRP2 5.7749 8.4649 4.6028 6.6008
EM-2 CTRP2 6.1229 7.7983 5.232 3.2662
JVM-3 CTRP2 6.4332 8.8756 4.9383 3.9507
LAMA-84 CTRP2 6.475 8.1155 5.3421 2.2173
Ki-JK CTRP2 6.5955 9.6192 4.6929 4.7014
WSU-DLCL2 CTRP2 6.6071 8.3137 5.3375 2.0448
EHEB CTRP2 6.6774 9.3169 4.901 3.7134
JURL-MK1 CTRP2 6.7457 8.7993 5.1985 2.4081
P12-Ichikawa CTRP2 6.7499 8.0318 5.5589 1.015
KMS-21-BM CTRP2 6.7643 8.6507 5.2813 2.0553
KMS-27 CTRP2 6.7855 7.9506 5.6151 0.7802
MOLM-13 CTRP2 6.8087 8.9901 5.1495 2.5169
Jurkat CTRP2 6.8105 10.277 4.5276 5.0399
HDLM-2 CTRP2 6.9378 9.1238 5.1703 2.2651
Peer CTRP2 6.9732 8.6099 5.428 1.2537
KE-97 CTRP2 6.9862 9.0733 5.2243 1.997
RPMI-8402 CTRP2 7.1144 10.8027 4.4872 4.7453
HT CTRP2 7.1811 9.5455 5.126 2.1394
NCO2 CTRP2 7.2592 9.1372 5.3545 1.2314
CML-T1 CTRP2 7.3205 8.8525 5.5073 0.6909
KE-37 CTRP2 7.4171 8.7537 5.5917 0.4037
KM-H2 CTRP2 7.4449 9.554 5.2735 1.3368
KHM-1B CTRP2 7.4573 8.9558 5.53 0.539
HEL CTRP2 7.493 8.5768 5.6896 0.1699
SU-DHL-1 CTRP2 7.738 8.7566 5.7171 0.079
KCL-22 CTRP2 7.7733 9.4234 5.4872 0.477
P31/FUJ CTRP2 7.9156 8.7908 5.7665 0.0241
DEL CTRP2 7.9346 9.3237 5.5905 0.2067
KMM-1 CTRP2 8.0228 10.828 5.0306 1.6377
NALM-6 CTRP2 8.0418 9.581 5.5389 0.2621
ALL-SIL CTRP2 8.0715 9.5753 5.5525 0.23
JVM-2 CTRP2 9.0144 11.1333 5.354 0.2888
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
769-P CTRP2 7.4054 9.2243 5.3943 0.9742
OS-RC-2 CTRP2 7.6251 11.2937 4.591 3.6464
TUHR4TKB CTRP2 7.8891 9.1577 5.6325 0.1544
BFTC-909 CTRP2 7.9203 9.1327 5.6528 0.1207
SNU-1272 CTRP2 8.0418 9.5085 5.5651 0.2177
KMRC-20 CTRP2 8.2227 9.7672 5.5415 0.2066
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW48 CTRP2 6.6735 9.0643 5.0212 3.2277
HCT 116 CTRP2 7.0539 10.2163 4.728 3.8612
COLO205 CTRP2 7.349 10.1237 4.9623 2.5614
OUMS-23 CTRP2 7.4919 8.5301 5.706 0.1438
LS513 CTRP2 7.5312 9.2041 5.4645 0.6729
DLD-1 CTRP2 7.5711 8.5506 5.7282 0.0952
LS411N CTRP2 7.8951 9.2759 5.5925 0.2147
HT115 CTRP2 8.0425 9.3473 5.6226 0.1345
LS180 CTRP2 8.0838 9.594 5.5505 0.2297
HT-29 CTRP2 8.0839 15.615 2.8338 9.873
SK-CO-1 CTRP2 8.2826 9.7929 5.5548 0.1731
SNU-C2A CTRP2 9.1719 12.2914 4.984 0.9912
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-182 CTRP2 7.1725 10.9054 4.4777 4.6993
Li-7 CTRP2 7.7472 11.5729 4.5375 3.7024
Hep 3B2.1-7 CTRP2 7.7668 9.1914 5.5726 0.2931
SNU-878 CTRP2 8.3795 9.7365 5.6093 0.0928
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2405 CTRP2 5.588 12.5811 2.3883 16.0542
MOR/CPR CTRP2 6.7323 8.0291 5.5498 1.067
NCI-H2291 CTRP2 6.7888 8.5567 5.3411 1.7902
HCC827 CTRP2 6.9092 8.5576 5.4144 1.3718
NCI-H460 CTRP2 7.0388 14.6172 2.5559 12.6321
RERF-LC-Ad1 CTRP2 7.0651 8.1914 5.6552 0.437
NCI-H211 CTRP2 7.1256 9.0511 5.3179 1.492
HCC2279 CTRP2 7.4279 14.0994 3.1036 9.842
BEN CTRP2 7.4753 8.6607 5.6518 0.2448
SBC-5 CTRP2 7.4917 8.4948 5.7185 0.1251
NCI-H196 CTRP2 7.5149 8.936 5.5637 0.4221
NCI-H650 CTRP2 7.5699 11.4168 4.4982 4.0761
COLO 699 CTRP2 7.5782 10.5692 4.8964 2.5458
NCI-H1299 CTRP2 7.6188 9.7083 5.2985 1.1072
HCC95 CTRP2 7.6562 9.2526 5.5023 0.4998
NCI-H1155 CTRP2 7.6812 9.3303 5.4829 0.5352
LCLC-103H CTRP2 7.6989 8.9652 5.6288 0.2115
NCI-H2106 CTRP2 7.709 11.88 4.3698 4.3977
Lu-99 CTRP2 7.772 8.9884 5.6486 0.1593
HCC15 CTRP2 7.7733 10.2072 5.166 1.4067
HCC1588 CTRP2 7.784 15.1086 2.8676 10.2013
NCI-H358 CTRP2 7.8196 11.1264 4.7861 2.6873
HCC44 CTRP2 7.9012 10.155 5.2527 1.0355
NCI-H2030 CTRP2 7.9304 9.5522 5.5046 0.3679
HCC2108 CTRP2 8.0184 9.7254 5.4759 0.3925
NCI-H1581 CTRP2 8.0559 9.5706 5.5482 0.2418
HCC78 CTRP2 8.075 9.6769 5.5169 0.2909
NCI-H1838 CTRP2 8.1514 9.8774 5.4735 0.3463
SHP-77 CTRP2 8.1559 9.7599 5.5184 0.2624
NCI-H1975 CTRP2 8.2505 10.2399 5.378 0.5058
Calu-3 CTRP2 8.2606 9.7012 5.5789 0.1462
NCI-H727 CTRP2 8.307 9.954 5.5067 0.2383
NCI-H292 CTRP2 8.4095 9.8675 5.5751 0.1234
HCC366 CTRP2 8.4104 9.9145 5.5592 0.1417
RERF-LC-A1 CTRP2 8.4811 9.9645 5.5674 0.1201
A-549 CTRP2 8.54 14.3497 3.7416 5.7664
NCI-H2009 CTRP2 8.7447 10.3483 5.5295 0.1188
CAL-12T CTRP2 8.7514 16.2898 2.964 8.4301
HCC1171 CTRP2 8.8987 10.6841 5.4692 0.159
HARA [Human squamous cell lung carcinoma] CTRP2 9.0907 10.7925 5.5 0.1001
HCC1833 CTRP2 9.6661 19.2627 2.155 10.1315
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-10 CTRP2 7.2354 10.8357 4.5539 4.3043
TE-9 CTRP2 7.3757 9.8795 5.0899 2.0552
COLO 680N CTRP2 8.3553 9.8721 5.5539 0.159
KYSE-140 CTRP2 10.4687 23.1273 0.8491 13.3357
KYSE-180 CTRP2 12.7688 23.8073 1.9432 7.3552
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-119 CTRP2 6.6277 8.5872 5.2202 2.4874
OVTOKO CTRP2 6.6844 8.7104 5.1996 2.4891
DOV13 CTRP2 6.7653 9.3011 4.9707 3.2971
Kuramochi CTRP2 7.3058 9.538 5.2031 1.7177
OVISE CTRP2 7.4009 8.9144 5.5205 0.5995
SNU-8 CTRP2 7.4757 9.2359 5.4247 0.8266
OVSAHO CTRP2 7.6619 9.2717 5.4973 0.5092
ONCO-DG-1 CTRP2 7.6804 9.6742 5.3435 0.9224
ES2 CTRP2 7.9442 9.0802 5.6795 0.0863
JHOC-5 CTRP2 10.8055 19.0497 2.9501 6.0647
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-3 CTRP2 7.3188 12.0189 4.041 6.2491
QGP-1 CTRP2 7.5988 9.1823 5.5043 0.5257
SUIT-2 CTRP2 7.6465 9.8658 5.2458 1.2534
KP-4 CTRP2 7.6869 12.7671 3.9338 6.146
SNU-213 CTRP2 7.7038 8.9102 5.6506 0.1739
CFPAC-1 CTRP2 8.273 9.9982 5.4775 0.2975
BxPC-3 CTRP2 8.3123 10.5033 5.3032 0.6505
HPAF-II CTRP2 8.4919 10.8094 5.2628 0.6583
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ACC-MESO-1 CTRP2 8.1884 9.6488 5.5706 0.1725
NCI-H28 CTRP2 8.6451 10.2729 5.5199 0.1453
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 CTRP2 8.424 10.2023 5.4623 0.2777
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 7.1331 8.3803 5.6108 0.5182
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-7951 CTRP2 6.3579 7.6482 5.4864 1.8051
Mel Ho CTRP2 6.9288 9.4341 5.0178 2.8768
SK-MEL-1 CTRP2 7.3015 8.8781 5.4874 0.7645
A-375 CTRP2 7.4817 10.8573 4.7043 3.3876
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh41 CTRP2 7.2679 10.5671 4.7034 3.6661
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GSU CTRP2 6.5208 7.9142 5.4705 1.6328
MKN1 CTRP2 7.0545 9.8114 4.9216 3.089
SNU-668 CTRP2 7.0646 8.3587 5.5862 0.6391
SNU-5 CTRP2 7.1586 8.7973 5.4481 1.0062
MKN45 CTRP2 7.4754 8.4602 5.7246 0.1201
SNU-620 CTRP2 7.489 8.6569 5.6587 0.2264
GSS CTRP2 7.529 9.0034 5.5435 0.4643
ECC12 CTRP2 7.6113 8.6642 5.7032 0.1191
AGS CTRP2 7.731 11.6784 4.4783 3.9497
NUGC-4 CTRP2 7.7499 9.4374 5.4715 0.5272
23132/87 CTRP2 8.2225 9.9621 5.4707 0.3265
KE-39 CTRP2 8.4309 10.7144 5.273 0.6639
SNU-719 CTRP2 8.4922 10.713 5.2999 0.5726
SNU-1077 CTRP2 7.9241 9.3733 5.5684 0.2471
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
B-CPAP CTRP2 6.831 8.4411 5.4209 1.4354
CAL-62 CTRP2 6.8618 8.3702 5.4714 1.2139
8305C CTRP2 7.4473 8.9108 5.5434 0.5096
8505C CTRP2 7.757 9.5567 5.4276 0.6358
CGTH-W-1 CTRP2 8.008 9.3423 5.6116 0.1564
BHT-101 CTRP2 8.4974 9.7179 5.656 0.0444
TT CTRP2 12.0331 26.7582 0.1517 13.4102
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 4.0485 10.2139 2.1289 20.584
HSC-3 CTRP2 7.4252 8.6147 5.6484 0.271
SNU-1066 CTRP2 7.6374 10.5436 4.9428 2.311
SNU-899 CTRP2 8.1144 9.2929 5.667 0.0746
SNU-1076 CTRP2 8.1702 9.3014 5.6834 0.0548
SNU-1041 CTRP2 8.2019 9.7685 5.5331 0.225
Detroit 562 CTRP2 8.2767 9.9484 5.4971 0.2627
SNU-46 CTRP2 8.3517 10.1908 5.4381 0.3433
BHY CTRP2 8.7219 10.2723 5.5474 0.1046
SNU-1214 CTRP2 8.8699 10.9764 5.355 0.3267
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 CTRP2 6.5464 10.9217 4.0105 7.6228
CAL-29 CTRP2 6.6443 9.7067 4.686 4.6509
639V CTRP2 6.9679 8.726 5.3726 1.4612
JMSU-1 CTRP2 7.361 10.3804 4.8508 2.9724
253J-BV CTRP2 7.5034 9.0578 5.5104 0.5642
BFTC-905 CTRP2 7.8737 9.3413 5.5602 0.2787
253J CTRP2 7.9724 9.2527 5.6299 0.1394
TCCSUP CTRP2 8.4564 9.9704 5.5565 0.1365
VM-CUB-1 CTRP2 10.2239 18.2425 2.9761 6.5895
5637 CTRP2 11.2834 25.5197 0.2504 14.0486
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7797).
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Cardiac Safety of TGF-beta Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study. Cardiovasc Toxicol. 2015 Oct;15(4):309-23.