Details of the Drug

General Information of Drug (ID: DMPB80O)

Drug Name
RO-26-9228
Synonyms Elocalcitol; BXL628; BXL-628; (23E)-1alpha-Fluoro-25-hydroxy-16,17,23,24-tetradehydro-26,27-bishomo-20-epicholecalciferol
Indication
Disease Entry ICD 11 Status REF
Urinary incontinence MF50.2 Discontinued in Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 442.6
Logarithm of the Partition Coefficient (xlogp) 5.7
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C29H43FO2
IUPAC Name
(1R,3Z,5S)-3-[(2E)-2-[(3aS,7aS)-1-[(E,2S)-6-ethyl-6-hydroxyoct-4-en-2-yl]-7a-methyl-3a,5,6,7-tetrahydro-3H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylidenecyclohexan-1-ol
Canonical SMILES
CCC(CC)(/C=C/C[C@H](C)C1=CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](C[C@@H](C3=C)F)O)C)O
InChI
InChI=1S/C29H43FO2/c1-6-29(32,7-2)17-8-10-20(3)25-14-15-26-22(11-9-16-28(25,26)5)12-13-23-18-24(31)19-27(30)21(23)4/h8,12-14,17,20,24,26-27,31-32H,4,6-7,9-11,15-16,18-19H2,1-3,5H3/b17-8+,22-12+,23-13-/t20-,24+,26-,27-,28+/m0/s1
InChIKey
LRLWXBHFPGSUOX-GJQYOBCGSA-N
Cross-matching ID
PubChem CID
11396600
CAS Number
199798-84-0
UNII
2WDS5F2V6Q
DrugBank ID
DB06194
TTD ID
D0I4GI

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Vitamin D3 receptor (VDR) TTK59TV VDR_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Urinary incontinence
ICD Disease Classification MF50.2
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vitamin D3 receptor (VDR) DTT VDR 1.69E-02 -0.23 -0.66
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 3.6249 4.5667 3.6219 16.1288
JM1 CTRP2 0.009 20.4877 -6.6662 46.2644
A4/Fukuda CTRP2 -12.1155 0.3234 -12.5559 84.4039
SK-MM-2 CTRP2 -8.6306 19.5116 -14.9351 63.29
KMS-26 CTRP2 -7.3051 -2.1427 -7.3211 82.714
KMS-21-BM CTRP2 -6.2344 1.2467 -6.4145 74.0088
KMS-34 CTRP2 -4.5174 7.1513 -5.8022 62.1802
MV4-11 CTRP2 -3.4752 7.8076 -4.8745 58.3033
NCI-H929 CTRP2 -1.9135 13.9528 -5.5923 51.4399
MOLM-13 CTRP2 -0.9139 7.3658 -1.9474 47.2341
EoL-1 CTRP2 -0.0791 6.3509 -0.7245 42.1501
EM-2 CTRP2 0.9571 18.3917 -4.7519 42.9476
Mono-Mac-1 CTRP2 1.4222 15.4699 -2.9147 39.9873
697 CTRP2 1.5061 2.5956 1.506 30.2348
OCI-AML-2 CTRP2 1.541 8.6429 -0.1292 30.8511
GA-10 CTRP2 1.6029 2.4405 1.6029 29.59
Pfeiffer CTRP2 1.6743 2.2932 1.6743 29.1142
KMS-12-BM CTRP2 1.7049 4.7283 1.5922 29.2894
OCI-Ly3 CTRP2 1.8582 3.4245 1.8542 27.9023
SUP-M2 CTRP2 1.8841 3.2869 1.8822 27.723
KHM-1B CTRP2 2.2947 11.6589 -0.2801 32.881
Peer CTRP2 2.369 4.3532 2.3386 24.5881
SU-DHL-8 CTRP2 2.3903 5.7692 2.1283 25.2476
Daudi CTRP2 2.4364 3.3422 2.4363 24.0373
Ki-JK CTRP2 2.4582 6.6923 1.9363 25.7132
NU-DHL-1 CTRP2 2.5131 3.667 2.5119 23.5299
NU-DUL-1 CTRP2 2.5779 5.1857 2.4564 23.5087
KMS-11 CTRP2 2.6371 10.5442 0.5702 29.6247
MOLT-16 CTRP2 2.7739 6.2117 2.4281 22.9982
OPM-2 CTRP2 3.0224 4.9965 2.9622 20.3368
JVM-2 CTRP2 3.0832 5.6671 1.0298 3.7557
A3/Kawakami CTRP2 3.089 4.3231 3.0832 19.7083
Ku812 CTRP2 3.157 9.7326 1.4616 25.329
MOLM-6 CTRP2 3.2825 10.681 1.1557 26.0026
Ri-1 CTRP2 3.303 5.6733 3.1452 18.8081
Kasumi-2 CTRP2 3.3612 4.1039 3.3609 17.877
PL21 CTRP2 3.3825 7.9661 2.4571 21.1183
Jurkat CTRP2 3.3903 6.9722 0.6129 5.4303
EB1 CTRP2 3.4256 5.1494 3.3718 17.6289
P12-Ichikawa CTRP2 3.498 5.1174 3.4528 17.1172
WSU-DLCL2 CTRP2 3.5375 4.0986 3.5374 16.7017
DND-41 CTRP2 3.564 4.3294 3.5634 16.5266
BL-70 CTRP2 3.5931 4.1865 3.5931 16.3308
RS4;11 CTRP2 3.6142 4.9531 3.592 16.2649
Karpas-299 CTRP2 3.6317 9.5926 2.0044 22.1223
SKM-1 CTRP2 3.6318 5.5418 3.5297 16.4229
KMS-28BM CTRP2 3.6402 8.3097 2.5821 19.9383
SU-DHL-1 CTRP2 3.6455 5.1506 3.6054 16.1172
DB CTRP2 3.6623 5.1084 3.6279 15.9859
LAMA-84 CTRP2 3.6917 6.064 1.208 1.9675
AML-193 CTRP2 3.7073 4.2545 3.7072 15.5704
HH [Human lymphoma] CTRP2 3.7377 6.3544 3.436 16.4359
Namalwa CTRP2 3.7415 5.0666 3.7156 15.4294
CA46 CTRP2 3.7877 5.5441 3.698 15.3415
RPMI-8226 CTRP2 3.7929 8.3529 2.7214 18.9953
TALL-1 [Human adult T-ALL] CTRP2 3.8012 6.0663 3.5903 15.6828
MHH-CALL-4 CTRP2 3.8064 7.6261 3.0423 17.7253
SU-DHL-6 CTRP2 3.8078 5.0712 3.7847 14.9783
JeKo-1 CTRP2 3.8384 4.4791 3.8381 14.6974
HEL CTRP2 3.8458 7.363 0.7165 4.13
KMS-18 CTRP2 3.8603 10.934 1.605 22.9576
SUP-T11 CTRP2 3.8708 5.5117 3.7937 14.7443
OCI-AML-3 CTRP2 3.8756 4.7243 3.8728 14.4585
ST486 CTRP2 3.8888 4.8318 3.8832 14.3794
Mino CTRP2 3.9137 4.6005 3.913 14.1975
RL CTRP2 3.9525 4.7212 3.9508 13.9421
M-07e CTRP2 3.9668 4.8616 3.9619 13.8579
HT CTRP2 4.02 5.0966 4.0045 13.5387
TF-1 CTRP2 4.034 5.6363 3.9469 13.6924
PF-382 CTRP2 4.0916 5.4278 4.0444 13.1703
RCH-ACV CTRP2 4.1606 5.3241 4.1312 12.6493
MOLT-13 CTRP2 4.1835 6.2491 3.6308 8.4032
SUP-T1 CTRP2 4.1873 6.0563 4.0144 12.9773
U-937 CTRP2 4.1968 6.1051 4.0112 12.96
DEL CTRP2 4.2307 5.1312 4.221 12.1159
NALM-6 CTRP2 4.2319 5.2008 4.2177 12.1228
HDLM-2 CTRP2 4.2374 14.8738 0.0462 26.8892
KE-37 CTRP2 4.2462 4.9778 4.2432 11.9898
MM1.S CTRP2 4.2476 10.6666 2.1063 20.1717
THP-1 CTRP2 4.2478 5.7971 4.1453 12.3229
L-540 CTRP2 4.2634 5.5901 4.2032 12.0708
BCP-1 CTRP2 4.3011 23.4472 -4.1494 34.8798
JVM-3 CTRP2 4.3038 5.3825 4.2763 11.689
BV-173 CTRP2 4.3115 5.683 4.2382 11.7961
ALL-SIL CTRP2 4.3267 5.9802 4.187 11.9305
Ci-1 CTRP2 4.3489 4.9518 4.3478 11.2994
HPB-ALL CTRP2 4.4038 6.0697 4.247 11.4792
Reh CTRP2 4.4481 7.2853 3.8566 12.8285
MOLM-16 CTRP2 4.481 6.0086 4.3478 10.8805
GDM-1 CTRP2 4.4838 5.8548 4.1121 5.5228
Hs 611.T CTRP2 4.4845 5.8517 4.3905 10.7173
F-36P CTRP2 4.52 6.2761 4.3122 10.8927
SUP-B15 CTRP2 4.5395 5.1428 4.5372 10.0334
P31/FUJ CTRP2 4.5743 5.6662 4.5252 9.9616
SU-DHL-4 CTRP2 4.589 5.5063 4.5642 9.7801
NB4 CTRP2 4.5991 8.478 2.9437 10.4175
SR CTRP2 4.6006 5.9654 4.4896 10.0049
KO52 CTRP2 4.6159 4.9898 4.6158 9.517
MOTN-1 CTRP2 4.6181 5.2816 4.6127 9.5202
SET-2 CTRP2 4.6211 5.3293 4.6134 9.5082
Toledo CTRP2 4.6245 5.466 4.6061 9.5215
L-428 CTRP2 4.6319 6.4389 4.3796 10.315
OCI-M1 CTRP2 4.645 5.1541 4.6439 9.3264
JJN-3 CTRP2 4.6484 6.1295 4.4969 9.8332
HD-MY-Z CTRP2 4.663 5.5865 4.6327 9.3058
Raji CTRP2 4.7166 8.0507 3.7966 12.367
MOLT-3 CTRP2 4.7209 5.7378 4.6708 8.9887
SIG-M5 CTRP2 4.7553 5.5992 4.7294 8.6757
Kasumi-1 CTRP2 4.765 6.0254 4.6533 8.9137
JURL-MK1 CTRP2 4.814 10.9396 2.5085 17.2894
KMS-20 CTRP2 4.8391 6.0575 4.7254 8.4281
CML-T1 CTRP2 4.8591 5.7845 4.8114 8.0602
KE-97 CTRP2 4.9319 13.3978 1.4038 21.0779
NOMO-1 CTRP2 4.9392 5.7431 4.9052 7.479
MOLP-8 CTRP2 4.9403 6.8353 3.3425 2.0896
Granta-519 CTRP2 4.9884 6.1011 4.876 7.4305
L-363 CTRP2 4.9933 6.0443 4.8973 7.3385
KYO-1 CTRP2 4.9962 9.3233 3.4664 13.0339
ME1 CTRP2 4.9969 7.416 4.3667 9.3741
HL-60 CTRP2 5.027 8.1844 4.0416 10.6117
OCI-AML-5 CTRP2 5.0945 6.3955 4.8944 7.0506
RPMI-8402 CTRP2 5.0971 6.747 4.7601 7.5584
EHEB CTRP2 5.1731 8.7464 3.9128 10.7947
U266B1 CTRP2 5.2727 6.3186 5.1141 5.7132
HEL 92.1.7 CTRP2 5.2856 5.9288 5.2447 5.1963
Mono-Mac-6 CTRP2 5.4065 9.4242 3.7973 10.7488
EJM CTRP2 5.416 8.6339 4.1948 9.0781
Karpas-422 CTRP2 5.4204 6.3017 5.2792 4.6687
K-562 CTRP2 5.4359 7.505 4.7608 6.6976
SU-DHL-10 CTRP2 5.4559 6.0604 5.3977 4.1245
P3HR-1 CTRP2 5.6003 6.2938 5.4745 3.419
KM-H2 CTRP2 5.636 20.3089 -4.2752 21.479
MHH-CALL-3 CTRP2 5.6477 9.3056 4.0725 9.0858
LP-1 CTRP2 5.7617 9.2743 4.1882 8.3644
SUP-HD1 CTRP2 5.7698 7.0696 5.2882 3.7515
AMO1 CTRP2 5.7902 6.9201 5.3801 3.3248
OCI-Ly19 CTRP2 5.9408 7.6425 5.1574 3.9331
KMS-27 CTRP2 6.0069 20.6121 -1.2708 26.3936
KCL-22 CTRP2 6.4612 11.3315 3.7397 8.8983
CMK CTRP2 6.7594 7.8538 5.6432 0.7083
RPMI-6666 CTRP2 7.7881 9.4114 5.4982 0.444
KMM-1 CTRP2 7.7945 12.6522 4.0605 5.4967
MOLP-2 CTRP2 7.8239 21.3905 -0.2008 20.3845
Karpas-620 CTRP2 7.9224 9.2221 5.6222 0.1613
OCI-Ly10 CTRP2 8.2799 10.1712 5.4163 0.4119
REC-1 CTRP2 9.7225 20.6275 1.5434 12.1297
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 4.9093 11.1409 2.4978 17.1124
TE15 CTRP2 5.4472 9.2448 3.9229 10.1386
TE-5 CTRP2 4.7299 5.3619 4.724 8.7772
OE21 CTRP2 4.8401 5.8868 4.7695 8.267
KYSE-30 CTRP2 5.3441 5.9292 5.3082 4.7889
KYSE-70 CTRP2 5.3961 7.6427 4.0255 3.9106
KYSE-410 CTRP2 5.4547 6.7235 5.1415 5.1117
TE-6 CTRP2 5.4675 6.623 5.1985 4.8528
KYSE-150 CTRP2 5.5118 23.7258 -3.244 31.2053
KYSE-510 CTRP2 5.5178 7.0587 5.0516 5.3145
TE-4 CTRP2 5.6317 7.5166 4.9413 5.5
TE-10 CTRP2 5.6916 7.0109 5.2428 4.1184
TE-14 CTRP2 6.0962 8.6419 4.7886 5.1793
TE-9 CTRP2 6.358 12.0323 3.3076 10.8673
TE-11 CTRP2 6.5012 8.946 4.9544 3.7718
EC-GI-10 CTRP2 6.596 10.3817 4.3165 6.2641
TE-1 CTRP2 6.6476 8.9732 5.0472 3.1609
KYSE-140 CTRP2 6.7693 10.7733 4.2535 6.237
KYSE-520 CTRP2 7.1592 9.0718 5.3278 1.4219
OE33 CTRP2 7.2879 10.9472 4.5358 4.3039
KYSE-180 CTRP2 9.9013 17.2385 3.2412 6.015
KYSE-450 CTRP2 10.054 18.2096 2.8896 7.0815
COLO 680N CTRP2 10.5545 21.6712 1.5939 10.8788
OE19 CTRP2 14.3441 30.2696 -0.0496 11.4407
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 9.7163 17.1412 3.1754 6.455
PSN1 CTRP2 4.0008 5.3272 3.394 3.5495
KP-3 CTRP2 4.292 8.8604 3.0007 16.6101
PaTu 8988s CTRP2 4.4704 7.222 3.9063 12.575
MIA PaCa-2 CTRP2 4.7075 5.97 4.605 9.2631
KP-4 CTRP2 5.2405 5.9206 5.1975 5.504
SU.86.86 CTRP2 5.2695 5.9248 5.2281 5.3049
TCC-Pan2 CTRP2 5.5185 8.0097 3.9359 4.0932
PK-59 CTRP2 5.5188 7.7203 4.7363 6.6045
PaTu 8988t CTRP2 5.6661 13.2228 0.7593 12.5321
Capan-1 CTRP2 5.7876 7.1495 5.2656 3.8055
SW1990 CTRP2 5.9088 7.4396 5.2308 3.691
HPAC CTRP2 6.1364 7.3946 5.4444 2.3498
AsPC-1 CTRP2 6.1813 7.8702 5.2429 3.1137
Panc 08.13 CTRP2 6.2128 7.3849 5.5088 1.9465
Capan-2 CTRP2 6.2476 8.1797 5.141 3.4229
Panc 02.03 CTRP2 6.2973 7.997 3.5294 0.3311
Hs 766T CTRP2 6.389 7.6696 5.4979 1.711
HuP-T3 CTRP2 6.4015 8.7444 4.9792 3.8337
SUIT-2 CTRP2 6.4628 7.9264 5.4252 1.8975
SNU-410 CTRP2 6.5534 13.9938 2.4855 13.7759
BxPC-3 CTRP2 6.67 17.2204 0.9688 18.9481
KP-2 CTRP2 6.7056 8.4644 5.3311 1.9364
YAPC CTRP2 6.9687 9.8968 4.8235 3.5983
L3.3 CTRP2 7.0271 9.3377 5.1269 2.3212
Panc 05.04 CTRP2 7.201 9.918 4.9657 2.7274
Panc 03.27 CTRP2 7.3434 18.0903 -0.4214 14.2274
CFPAC-1 CTRP2 7.692 13.6002 3.5359 7.7202
PaTu 8902 CTRP2 7.7927 9.1854 5.5853 0.2596
QGP-1 CTRP2 7.973 9.6833 5.4729 0.4179
HuP-T4 CTRP2 8.0075 20.4941 0.3832 18.402
PK-45H CTRP2 8.107 9.7849 5.4898 0.3306
SNU-213 CTRP2 8.138 9.3851 5.6439 0.0934
HPAF-II CTRP2 8.6374 14.1798 3.8809 5.1234
DAN-G CTRP2 8.8653 29.5356 -3.4411 25.9739
Panc 04.03 CTRP2 12.144 33.4201 -2.9538 20.6369
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 47 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 6.1881 12.0227 3.1741 11.7316
WM266-4 CTRP2 2.5006 3.2624 2.5006 23.6091
UACC-62 CTRP2 3.1717 5.5047 3.0385 19.5957
WM88 CTRP2 3.2176 11.4004 0.7569 27.4354
WM115 CTRP2 4.1994 5.7479 4.1034 12.622
G-361 CTRP2 4.6058 5.5504 4.5765 9.6833
HMCB CTRP2 4.8125 7.6231 2.8814 4.4035
SK-MEL-24 CTRP2 4.8564 6.2455 4.6879 8.5133
WT2-iPS CTRP2 4.9809 6.9635 3.3083 2.1839
UACC-257 CTRP2 5.1198 6.0846 5.0241 6.4959
COLO 792 CTRP2 5.1545 7.4608 3.1854 2.4833
COLO 829 CTRP2 5.1664 6.4527 4.9503 6.6351
HT-144 CTRP2 5.1711 7.2051 3.3124 1.9159
RVH-421 CTRP2 5.1785 6.9556 4.7563 7.3567
SK-MEL-2 CTRP2 5.2194 6.2614 3.7374 0.3195
Hs 895.T CTRP2 5.2365 6.0774 5.1535 5.6738
SK-MEL-1 CTRP2 5.5902 6.1466 5.5175 3.2854
A2058 CTRP2 5.6354 6.7405 3.7274 0.1735
WM1799 CTRP2 5.7813 11.6722 3.0084 13.2055
Hs 940.T CTRP2 5.8464 6.9847 5.4005 3.1147
IGR-37 CTRP2 5.8881 17.6203 0.1257 23.0443
IGR-39 CTRP2 5.9366 7.2501 3.6597 0.2031
SK-MEL-3 CTRP2 6.0759 9.0923 4.5466 6.2351
Hs 294T CTRP2 6.1728 7.5122 3.655 0.1502
Hs 944.T CTRP2 6.4487 10.1003 4.3428 6.4081
IPC-298 CTRP2 6.4572 7.963 5.4035 1.9938
MDA-MB-435S CTRP2 6.5822 11.4552 3.7731 8.545
COLO 741 CTRP2 6.6277 8.9723 5.0335 3.247
WM793 CTRP2 6.6292 12.4605 3.3097 10.3651
A-375 CTRP2 6.6629 15.3395 1.9017 15.7579
CJM [Human melanoma] CTRP2 6.6639 9.4854 4.8089 4.1126
COLO 800 CTRP2 6.67 8.6874 5.2009 2.5044
Hs 852.T CTRP2 6.7652 9.0437 5.0946 2.7969
SK-MEL-5 CTRP2 6.9158 9.6818 4.8907 3.4031
Hs 936.T CTRP2 7.0053 8.9073 5.3124 1.6426
SK-MEL-30 CTRP2 7.0751 12.2969 3.73 7.8921
K029AX CTRP2 7.1042 8.7435 5.4422 1.0756
Hs 839.T CTRP2 7.1291 8.3425 5.6241 0.4831
Mel JuSo CTRP2 7.1453 8.8347 5.4247 1.0971
SK-MEL-28 CTRP2 7.1591 7.7901 5.8424 0.0391
SK-MEL-31 CTRP2 7.4646 9.0054 5.5135 0.5791
MeWo CTRP2 7.7534 20.9948 -0.0587 20.1088
Mel Ho CTRP2 7.8411 14.4771 3.2153 8.7623
IGR-1 CTRP2 7.8482 9.6494 5.432 0.5736
LOX-IMVI CTRP2 8.2604 9.9634 5.4853 0.2878
A101D CTRP2 9.3943 21.1778 -0.5441 11.6684
WM983B CTRP2 10.0614 55.7935 -15.5669 36.6373
⏷ Show the Full List of 47 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 4.4882 6.5459 3.1741 3.6009
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-DZ CTRP2 3.6665 4.4635 3.6655 15.8454
IMR-32 CTRP2 3.7481 4.3826 3.7479 15.2988
Kelly CTRP2 4.0796 5.3872 4.0373 13.2331
CHP-212 CTRP2 4.2512 6.2098 4.0399 12.6918
SK-N-BE(2) CTRP2 4.431 6.5966 4.107 11.9164
SK-N-AS CTRP2 4.551 5.4329 4.532 10.0134
NH-6 CTRP2 4.736 5.9842 4.6325 9.0771
SK-N-FI CTRP2 4.9975 5.7882 4.9602 7.1022
NB1 CTRP2 5.1214 6.1892 4.9941 6.6008
CHP-126 CTRP2 5.2925 6.6364 5.0108 6.0549
KP-N-SI9s CTRP2 6.103 9.2494 4.4905 6.4192
KP-N-YN CTRP2 6.205 7.9302 5.2318 3.1181
SK-N-SH CTRP2 6.8626 8.521 3.5548 0.1445
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1079 CTRP2 4.1947 17.9648 -1.5197 30.7313
SNU-478 CTRP2 5.3803 6.0392 5.3211 4.6314
HuH-28 CTRP2 5.4565 6.0498 5.4013 4.11
SNU-869 CTRP2 6.0702 7.3838 5.3961 2.6754
SNU-1196 CTRP2 6.9584 8.7983 5.3341 1.6146
SNU-245 CTRP2 7.4261 23.7512 -1.6856 24.7503
SNU-308 CTRP2 8.148 16.6895 2.3568 11.5657
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-673 CTRP2 3.9163 4.9245 3.9075 14.2069
SK-ES-1 CTRP2 4.4546 6.0317 4.3129 11.0869
HOS CTRP2 4.5428 6.4834 3.2445 3.1683
TC71 CTRP2 4.7406 9.0572 3.3497 14.1107
SK-N-MC CTRP2 5.0419 5.7781 5.0099 6.7878
MG-63 CTRP2 5.154 5.9527 5.0961 6.1326
SJSA-1 CTRP2 5.3509 6.0545 5.2848 4.8515
CAL-78 CTRP2 5.3761 6.0672 5.3088 4.6885
MHH-ES-1 CTRP2 5.5683 7.3973 4.9394 5.6534
U2OS CTRP2 5.6032 6.7117 5.2972 4.111
Hs 822.T CTRP2 6.1821 7.078 5.6373 1.463
G-292 clone A141B1 CTRP2 6.4488 7.6467 5.5501 1.4147
SW1353 CTRP2 7.3608 9.3392 5.3215 1.2505
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 68 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1500 CTRP2 3.5275 7.3253 2.866 19.1727
DU4475 CTRP2 3.627 4.3933 3.6263 16.1074
HCC2218 CTRP2 3.8435 5.6087 3.7459 14.9977
CAL-148 CTRP2 3.9713 14.6493 -0.088 27.8935
BT-20 CTRP2 4.9361 6.3934 4.7243 8.1454
T-47D CTRP2 5.0982 8.0273 4.1852 9.8557
HCC1143 CTRP2 5.1027 7.2232 4.5605 8.3301
ZR-75-1 CTRP2 5.3344 8.3678 3.6178 5.849
Hs 578Bst CTRP2 5.3764 6.1291 5.2907 4.7536
HCC1569 CTRP2 5.4707 6.6831 5.1756 4.9347
ZR-75-30 CTRP2 5.5068 13.9275 1.6463 18.9729
MDA-MB-157 CTRP2 5.522 6.4078 5.346 4.13
HCC1937 CTRP2 5.5929 13.416 1.9759 17.5989
HCC1419 CTRP2 5.7375 8.4165 4.5938 6.7168
MDA-MB-361 CTRP2 5.7428 6.5812 5.4964 2.9606
UACC-812 CTRP2 5.8016 8.151 4.7825 5.7921
KPL-1 CTRP2 5.806 20.4907 -1.3783 27.03
HCC1954 CTRP2 5.8144 7.692 5.0218 4.7639
SK-BR-3 CTRP2 5.8973 8.243 4.8203 5.4364
CAL-85-1 CTRP2 6.088 8.1012 3.4021 0.7494
HCC1395 CTRP2 6.1042 7.5451 5.3433 2.8336
BT-474 CTRP2 6.1593 7.5011 5.4095 2.4552
CAL-51 CTRP2 6.24 7.7268 5.3601 2.5203
JIMT-1 CTRP2 6.2687 8.1674 5.1636 3.2915
HCC1806 CTRP2 6.2989 7.62 5.4573 2.0179
Hs 578T CTRP2 6.407 8.2636 5.2206 2.8227
HMC-1-8 CTRP2 6.446 8.3344 5.2144 2.7859
MDA-MB-468 CTRP2 6.4474 7.8944 5.4299 1.901
MDA-MB-231 CTRP2 6.6687 9.7644 4.6756 4.6548
HCC1428 CTRP2 6.825 9.4535 4.9384 3.3407
EFM-192A CTRP2 6.8287 37.6886 -9.1289 35.9642
HDQ-P1 CTRP2 8.0289 9.4688 5.5745 0.2064
CAMA-1 CTRP2 8.2897 23.7716 -1.0246 21.7624
MCF-7 CTRP2 8.5167 10.487 5.3948 0.3677
HCC202 CTRP2 8.8563 10.5498 5.5002 0.132
BT 131 CTRP2 2.4592 3.0212 2.4592 23.8848
BT 145 CTRP2 2.4856 3.4892 2.4852 23.7107
BT 330 CTRP2 2.5381 3.1085 2.5381 23.3594
BT 239 CTRP2 2.586 2.9316 2.586 23.0404
BT 228 CTRP2 2.7557 3.337 2.7557 21.9094
BT 248 CTRP2 2.806 3.5356 2.8059 21.5751
BT 428 CTRP2 2.8325 3.6662 2.8323 21.3987
BT 216 CTRP2 2.8604 4.2784 2.8511 21.2433
BT 359 CTRP2 2.9153 4.5103 2.896 20.9113
BT 286 CTRP2 2.9559 3.9602 2.9548 20.5796
BT 422 CTRP2 3.037 4.6897 3.0099 20.127
BT 271 CTRP2 3.0566 3.849 3.0565 19.9054
BT 416 CTRP2 3.106 4.7353 3.0784 19.6689
BT 440 CTRP2 3.3017 5.1142 3.2444 18.4666
BT 504 CTRP2 3.3786 4.3456 3.3765 17.7669
BT147 CTRP2 3.5658 5.0567 3.5315 16.6285
BT 231 CTRP2 3.5823 4.5956 3.5779 16.4176
BT 112 CTRP2 3.6503 4.2739 3.6501 15.9504
BT164 CTRP2 3.6837 4.8338 3.6723 15.7655
BT 139 CTRP2 3.698 4.18 3.698 15.6321
BT 482 CTRP2 3.7203 4.7671 3.7131 15.5073
BT 159 CTRP2 3.9845 4.6374 3.984 13.7249
BT 245 CTRP2 3.9956 5.549 3.9216 13.9023
BT 333 CTRP2 4.079 5.702 3.9824 13.426
BT 172 CTRP2 4.1676 5.9013 4.0334 12.9697
BT 179 CTRP2 4.1695 5.3262 4.1404 12.589
BT 340 CTRP2 4.2122 5.656 4.1359 12.468
BT 444 CTRP2 4.3606 5.8767 4.2497 11.602
BT 232 CTRP2 4.6735 6.4281 4.4283 10.0122
BT 498 CTRP2 5.0323 10.9082 2.7249 15.9429
BT 328 CTRP2 5.3593 6.0026 5.3077 4.7439
BT 320 CTRP2 6.1632 7.5896 5.3684 2.6202
BT 224 CTRP2 7.0388 9.276 5.163 2.1681
⏷ Show the Full List of 68 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 5.8747 6.3956 5.7131 1.7589
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF539 CTRP2 3.5746 4.7342 3.5649 16.4865
SF268 CTRP2 4.1649 5.2676 4.1418 12.5993
D283 Med CTRP2 4.2597 5.3203 4.2363 11.9688
U-251MG CTRP2 4.3477 5.2325 4.336 11.3428
KNS-42 CTRP2 4.5904 6.2112 4.4091 10.3275
SNU-466 CTRP2 4.831 5.3806 4.8272 8.0966
Hs 683 CTRP2 4.9475 5.8504 4.8942 7.4908
GB-1 CTRP2 5.2855 5.8598 5.2583 5.1487
KNS-81 CTRP2 5.3949 5.8854 5.3718 4.4061
SNB-75 CTRP2 5.4004 8.401 4.2942 8.7018
TM-31 CTRP2 5.4637 7.0817 3.5223 0.8095
Daoy CTRP2 5.5044 10.3572 3.423 12.0863
KALS-1 CTRP2 5.6044 6.4483 5.4153 3.6378
LN-229 CTRP2 5.6316 6.2111 5.5395 3.0837
U-118MG CTRP2 5.6337 7.336 5.031 5.1249
LN-18 CTRP2 5.8925 6.4602 5.6995 1.7724
GMS-10 CTRP2 5.9412 7.3235 3.6351 0.2466
ONS-76 CTRP2 6.0611 13.9206 2.1202 16.1083
SF126 CTRP2 6.0626 8.9329 4.6153 5.9718
M059K CTRP2 6.2936 7.6522 3.6502 0.1318
GOS-3 CTRP2 6.3336 7.8196 3.6066 0.1838
SF295 CTRP2 6.3992 7.8657 5.4098 2.0556
DK-MG CTRP2 6.6764 8.1807 5.4458 1.5259
YKG-1 CTRP2 6.7355 8.3221 5.4171 1.5632
SW1783 CTRP2 6.7596 8.7994 5.2077 2.3525
Becker CTRP2 7.0589 9.4198 5.1086 2.3522
8-MG-BA CTRP2 7.401 16.4269 0.4126 11.0337
SW1088 CTRP2 7.4501 12.1206 4.0829 5.8877
SNU-201 CTRP2 7.4626 9.7105 5.2148 1.5209
GaMG CTRP2 7.6232 9.2733 5.4793 0.5766
SNU-626 CTRP2 7.6246 9.0471 5.5681 0.3601
SNU-738 CTRP2 7.6695 9.5385 5.3941 0.7821
T98G CTRP2 7.6763 13.3996 3.622 7.4013
SNU-489 CTRP2 7.6896 9.4456 5.441 0.6396
SNU-1105 CTRP2 7.8768 8.933 5.7059 0.07
U-87MG ATCC CTRP2 7.8814 18.5969 1.2256 15.9634
CCF-STTG1 CTRP2 7.9561 9.2997 5.6073 0.1749
42-MG-BA CTRP2 8.1618 16.856 2.2855 11.8065
A-172 CTRP2 8.3379 9.8833 5.5435 0.1763
DBTRG-05MG CTRP2 8.979 10.4847 5.5647 0.0626
YH-13 CTRP2 9.8013 23.4284 -1.337 13.6682
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-1 CTRP2 3.5561 4.3465 3.5554 16.5799
JHUEM-2 CTRP2 4.1421 8.2857 3.1091 16.5679
HEC-50B CTRP2 4.6645 6.9272 4.2308 10.7886
HEC-1-A CTRP2 4.6926 6.5812 4.3942 10.0857
KLE CTRP2 5.2847 6.4217 5.0886 5.7758
ESS-1 CTRP2 5.4774 7.5562 3.3286 1.5012
MFE-296 CTRP2 5.5112 6.9687 5.087 5.1874
MFE-319 CTRP2 5.9227 16.4678 -0.6477 17.5065
HEC-151 CTRP2 6.0767 7.7945 5.1961 3.5036
JHUEM-3 CTRP2 6.3251 8.3488 5.1169 3.3892
AN3-CA CTRP2 6.3652 8.7973 4.9253 4.1198
HEC-251 CTRP2 6.6963 10.8385 4.1666 6.7179
HEC-59 CTRP2 6.6977 10.0608 4.5513 5.1219
HEC-1-B CTRP2 6.7402 12.0655 3.5922 9.0154
JHUEM-7 CTRP2 6.8362 8.5721 5.3637 1.6456
RL95-2 CTRP2 7.0989 12.9499 3.4262 9.0871
HEC-265 CTRP2 7.3472 8.4857 5.6647 0.2686
HEC-6 CTRP2 7.9021 15.5638 2.73 10.5454
EFE-184 CTRP2 7.9721 16.5164 2.3151 11.9934
EN CTRP2 8.0482 9.5388 5.5567 0.2298
HEC-108 CTRP2 10.062 16.3949 3.7096 4.2294
Ishikawa (Heraklio) 02 ER- CTRP2 7.3661 8.217 5.7696 0.0836
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UO-31 CTRP2 2.9027 3.9316 2.9015 20.9344
CAL-54 CTRP2 4.7612 5.9262 4.6744 8.8496
KMRC-2 CTRP2 5.2078 5.8477 5.1766 5.6804
KMRC-3 CTRP2 5.2927 7.986 4.3931 8.5424
VMRC-RCZ CTRP2 5.5049 10.1471 2.1421 6.6666
TUHR14TKB CTRP2 5.6118 6.8419 5.2456 4.2977
Caki-2 CTRP2 5.8175 7.2446 3.615 0.3352
SNU-1272 CTRP2 6.1842 7.1671 5.5949 1.6362
RCC10RGB CTRP2 6.4348 8.4244 5.162 3.0203
Caki-1 CTRP2 6.8215 12.1105 2.0605 5.11
KMRC-20 CTRP2 6.8541 8.125 5.5763 0.8493
786-O CTRP2 7.3289 11.4081 4.3428 5.0185
TUHR10TKB CTRP2 7.5863 8.5597 5.7306 0.0895
VMRC-RCW CTRP2 7.6514 13.3248 3.6408 7.363
OS-RC-2 CTRP2 7.7726 12.8934 3.931 6.0375
TUHR4TKB CTRP2 7.8653 9.1169 5.638 0.1522
KMRC-1 CTRP2 7.9091 9.151 5.6423 0.1365
ACHN CTRP2 10.9244 20.8585 2.201 8.4435
769-P CTRP2 13.6363 32.4344 -1.4873 15.7318
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H747 CTRP2 3.798 7.4921 3.0877 17.5743
SNU-C1 CTRP2 4.0481 6.4593 3.7399 14.3982
COLO 320 CTRP2 4.2051 6.8036 3.7885 13.763
SNU-C5 CTRP2 4.4969 5.8038 4.4147 10.5929
LoVo CTRP2 4.5632 5.708 4.5058 10.0645
HT-55 CTRP2 4.6854 7.8484 3.8568 12.2049
SW620 CTRP2 4.6868 6.7115 4.3392 10.3109
CCK-81 CTRP2 4.6912 12.0953 1.2205 17.5506
LS123 CTRP2 4.9532 6.1533 4.8221 7.7327
C2BBe1 CTRP2 4.9935 5.9603 4.9194 7.2584
RKO CTRP2 5.0137 7.1312 4.5101 8.761
SW948 CTRP2 5.1524 5.9756 5.0888 6.1635
HT115 CTRP2 5.2532 9.8087 3.468 12.4455
CL-11 CTRP2 5.2869 6.3638 5.1129 5.6773
SNU-175 CTRP2 5.3338 12.8716 2.022 17.98
SNU-1033 CTRP2 5.3574 6.8627 4.9804 6.0032
KM12 CTRP2 5.439 6.6987 5.1362 5.1736
LS1034 CTRP2 5.4826 7.1637 4.9679 5.7403
T84 CTRP2 5.4987 7.5318 4.8083 6.3546
CW-2 CTRP2 5.4997 10.0559 3.5684 11.4958
SW48 CTRP2 5.6079 6.3559 5.4577 3.463
HCT 8 CTRP2 5.71 6.2367 5.6135 2.5813
HCT 15 CTRP2 5.7619 7.3928 5.1224 4.4578
SNU-407 CTRP2 5.7681 7.6341 5.009 4.9167
HCC-56 CTRP2 5.9658 7.6552 5.1726 3.8189
SNU-C4 CTRP2 6.0749 18.7912 -0.3036 23.8587
LS513 CTRP2 6.0751 7.5371 5.3235 2.9714
GP2d CTRP2 6.0783 13.1486 2.5205 14.5479
COLO 678 CTRP2 6.1323 7.5724 5.3523 2.7438
SK-CO-1 CTRP2 6.1875 7.5416 5.4115 2.3966
SNU-61 CTRP2 6.2578 12.3593 3.063 12.0494
OUMS-23 CTRP2 6.2581 7.7998 5.3378 2.5823
DLD-1 CTRP2 6.2684 7.3288 5.578 1.5681
SW1417 CTRP2 6.2814 7.785 5.3629 2.4385
SNU-C2A CTRP2 6.6266 8.469 5.2763 2.2629
MDST8 CTRP2 6.6526 8.5246 5.2673 2.2624
COLO201 CTRP2 6.8971 8.9365 5.2321 2.0766
LS411N CTRP2 6.9026 8.472 5.4493 1.251
NCI-H508 CTRP2 6.9697 12.0073 3.7946 7.7993
LS180 CTRP2 7.2746 9.8912 5.0239 2.4158
COLO205 CTRP2 7.3322 12.6538 3.7418 7.4388
HCT 116 CTRP2 7.4948 9.125 5.4794 0.6545
HT-29 CTRP2 7.8829 9.0157 5.6798 0.0958
RCM-1 [Human ESC] CTRP2 7.9016 9.4923 5.5153 0.3572
SNU-503 CTRP2 8.2242 10.037 5.4437 0.3781
NCI-H716 CTRP2 8.7211 10.327 5.5285 0.1234
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-5 CTRP2 3.3539 5.6531 3.2051 18.4376
PLC/PRF/5 CTRP2 3.9921 5.2879 3.4061 3.5114
JHH-2 CTRP2 4.3018 5.7407 3.432 2.7232
SNU-761 CTRP2 5.068 6.3343 4.8876 7.1524
SNU-182 CTRP2 5.3233 6.3403 5.1606 5.3933
JHH-6 CTRP2 5.3711 6.4036 3.7467 0.2271
SNU-398 CTRP2 5.3848 9.5255 3.7276 11.0846
HuH-1 CTRP2 5.7701 7.2318 3.6003 0.3909
SNU-475 CTRP2 5.8772 7.3965 3.5827 0.3839
JHH-1 CTRP2 5.8935 6.9181 3.7594 0.0736
SNU-423 CTRP2 6.2392 7.6524 5.3964 2.3701
Li-7 CTRP2 6.2558 7.6116 5.4292 2.2055
HLF CTRP2 6.4886 7.8825 3.6406 0.1092
Hep-G2 CTRP2 6.5192 9.0957 4.8941 3.9923
SK-HEP-1 CTRP2 7.2488 10.2009 4.8637 3.0627
Hep 3B2.1-7 CTRP2 7.3468 9.3103 5.3266 1.2462
SNU-449 CTRP2 7.3625 11.7099 4.2206 5.4609
JHH-4 CTRP2 7.9275 14.617 3.2079 8.6625
SNU-878 CTRP2 8.1968 9.9616 5.4606 0.3549
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 137 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1341 CTRP2 3.1109 4.9396 3.0632 19.7046
NCI-H1155 CTRP2 3.1849 6.4051 2.8182 20.3456
NCI-H810 CTRP2 3.4212 4.369 3.4192 17.4827
NCI-H1694 CTRP2 3.4866 4.579 3.4809 17.0594
NCI-H2106 CTRP2 3.6702 6.6986 3.2492 17.3256
DMS 53 CTRP2 3.7502 5.7203 3.6211 15.7299
NCI-H841 CTRP2 3.7971 6.4747 3.4622 16.1637
DV-90 CTRP2 4.0666 4.9594 4.0604 13.1972
NCI-H2087 CTRP2 4.0831 6.9848 3.5897 14.862
NCI-H446 CTRP2 4.1057 6.5325 3.7777 14.089
NCI-H2029 CTRP2 4.2004 5.4887 4.1519 12.4499
NCI-H1944 CTRP2 4.2582 5.9555 4.1186 12.386
NCI-H647 CTRP2 4.2627 5.3678 4.2344 11.9654
NCI-H211 CTRP2 4.3967 7.5819 3.678 13.664
NCI-H1693 CTRP2 4.4076 5.206 4.3996 10.9314
DMS 454 CTRP2 4.4802 7.6022 3.7556 13.1382
NCI-H1581 CTRP2 4.4916 7.2514 3.9164 12.4783
COLO 668 CTRP2 4.4931 5.9028 4.3879 10.6995
DMS 79 CTRP2 4.575 5.3534 4.564 9.8262
SK-MES-1 CTRP2 4.6246 5.9202 4.5269 9.7978
ChaGo-K-1 CTRP2 4.6491 5.6014 4.6157 9.4091
NCI-H1105 CTRP2 4.6908 7.1474 3.0265 3.9338
NCI-H1666 CTRP2 4.7131 6.4222 4.4732 9.7298
EKVX CTRP2 4.7249 7.5079 4.0486 11.3403
NCI-H1184 CTRP2 4.7253 6.6179 4.4157 9.9116
NCI-H1915 CTRP2 4.7426 5.3768 4.7363 8.6941
NCI-H1703 CTRP2 4.817 7.3841 4.1974 10.5117
NCI-H1975 CTRP2 4.9054 9.1622 3.4579 13.2801
EBC-1 CTRP2 4.9065 13.4186 1.3708 21.2481
NCI-H522 CTRP2 4.9291 6.0387 4.8288 7.7809
HCC4006 CTRP2 4.9468 6.8444 4.5621 8.7353
COR-L51 CTRP2 4.9848 5.9326 4.9165 7.2958
NCI-H2081 CTRP2 5.0068 7.0043 4.5578 8.5912
HOP-62 CTRP2 5.0727 5.922 5.0147 6.6741
LUDLU-1 CTRP2 5.0799 5.96 5.0136 6.6555
NCI-H2196 CTRP2 5.0905 6.3461 4.9078 7.0121
NCI-H1355 CTRP2 5.1338 6.9062 4.7314 7.5724
NCI-H1563 CTRP2 5.1359 6.0691 5.0461 6.3674
EPLC-272H CTRP2 5.1537 16.7946 -0.0899 25.1822
NCI-H358 CTRP2 5.1762 6.1323 5.0715 6.1536
NCI-H2170 CTRP2 5.201 6.2338 5.066 6.1006
NCI-H1793 CTRP2 5.2264 6.2386 5.092 5.9297
NCI-H1373 CTRP2 5.2347 7.8188 4.4167 8.5834
NCI-H1838 CTRP2 5.2371 7.6806 4.4844 8.3021
COR-L88 CTRP2 5.2391 7.746 4.4554 8.4152
NCI-H1568 CTRP2 5.2421 6.663 4.947 6.4392
NCI-H69 CTRP2 5.244 7.1329 4.7444 7.2352
HOP-92 CTRP2 5.2788 6.7245 4.9595 6.292
KNS-62 CTRP2 5.2924 7.9075 4.4304 8.3902
Lu-99 CTRP2 5.3067 5.911 5.2714 5.0359
RERF-LC-A1 CTRP2 5.3394 11.0841 2.9153 14.5065
Calu-6 CTRP2 5.3469 6.6718 5.0526 5.7455
NCI-H1339 CTRP2 5.3475 7.1224 3.4468 1.1805
NCI-H2228 CTRP2 5.3494 8.1946 4.3466 8.6015
LCLC-97TM1 CTRP2 5.3865 6.7052 5.0793 5.5356
COR-L95 CTRP2 5.4044 6.8711 5.0245 5.7068
DMS 273 CTRP2 5.4216 7.2597 3.4267 1.1842
NCI-H2444 CTRP2 5.4493 6.3185 5.3038 4.4935
SW1271 CTRP2 5.4525 6.6863 5.1556 5.0616
NCI-H526 CTRP2 5.4636 6.0699 5.4034 4.0811
NCI-H1734 CTRP2 5.4833 6.6706 5.194 4.829
HCC827 CTRP2 5.4839 12.3628 1.7447 13.7558
HCC1438 CTRP2 5.5274 5.943 5.5043 3.5234
HCC15 CTRP2 5.5284 6.1609 5.4456 3.733
NCI-H226 CTRP2 5.5406 7.0091 5.0973 5.0737
COLO 699 CTRP2 5.5736 6.5433 5.3425 4.0063
NCI-H889 CTRP2 5.5827 7.4894 4.9085 5.7474
HCC2935 CTRP2 5.5864 6.1328 5.5179 3.2951
Calu-1 CTRP2 5.6144 6.0935 5.5609 3.054
NCI-H520 CTRP2 5.6268 7.7143 4.8401 5.9302
LXF 289 CTRP2 5.6334 8.3501 4.5333 7.1921
LK2 CTRP2 5.6372 11.999 2.7213 14.6504
NCI-H1435 CTRP2 5.709 9.2 4.1791 8.5119
NCI-H292 CTRP2 5.7181 6.4232 5.5434 2.8342
DMS 114 CTRP2 5.722 7.448 5.0587 4.8107
NCI-H2009 CTRP2 5.7587 6.668 5.4713 3.0234
NCI-H196 CTRP2 5.7836 6.5003 5.5744 2.5441
Sq-1 CTRP2 5.7908 7.5713 5.0605 4.6526
NCI-H2286 CTRP2 5.7991 8.4322 4.6404 6.3926
NCI-H1395 CTRP2 5.8197 7.5622 5.091 4.4634
NCI-H23 CTRP2 5.8347 7.3925 5.1885 4.0239
NCI-H441 CTRP2 5.9018 10.97 2.7622 8.6087
NCI-H2291 CTRP2 5.9363 14.7658 1.5933 18.2708
COR-L105 CTRP2 5.9653 8.4671 3.1938 1.5334
NCI-H2172 CTRP2 6 7.4282 5.3151 3.1522
NCI-H661 CTRP2 6.0345 8.9372 4.5897 6.1336
HCC1195 CTRP2 6.1087 8.5816 4.829 4.9862
HCC1588 CTRP2 6.1127 7.1202 5.5623 1.8984
Calu-3 CTRP2 6.1412 9.0192 4.6369 5.7322
NCI-H1755 CTRP2 6.1512 8.2123 5.0481 3.9862
HARA [Human squamous cell lung carcinoma] CTRP2 6.2187 7.596 5.4086 2.3542
NCI-H2023 CTRP2 6.2821 8.5493 4.9841 4.0185
NCI-H2110 CTRP2 6.3221 8.2722 5.1527 3.2451
MOR/CPR CTRP2 6.3606 8.4521 5.0929 3.4293
NCI-H1650 CTRP2 6.3692 8.96 4.8476 4.4373
NCI-H2126 CTRP2 6.4557 8.0176 5.376 2.1081
T3M-10 CTRP2 6.4652 8.5846 5.1056 3.2043
HCC1833 CTRP2 6.492 9.6411 4.6041 5.2432
PC-14 CTRP2 6.6105 13.4469 2.8037 12.4292
NCI-H1869 CTRP2 6.6166 8.2318 5.3829 1.8505
RERF-LC-Ad1 CTRP2 6.6414 7.7914 5.604 0.9672
HCC366 CTRP2 6.7082 9.8816 4.647 4.71
NCI-H2342 CTRP2 6.7483 8.9977 5.1052 2.778
SHP-77 CTRP2 6.8475 8.6158 5.3504 1.6828
HCC2279 CTRP2 6.8564 10.138 4.6285 4.555
VMRC-LCD CTRP2 6.8965 9.9876 4.7298 4.0814
IA-LM CTRP2 6.997 8.4727 5.5021 0.9702
HCC1171 CTRP2 7.0368 9.129 5.2297 1.9163
LOU-NH91 CTRP2 7.1096 9.4169 5.1415 2.1646
BEN CTRP2 7.2071 8.323 5.6673 0.3265
NCI-H2122 CTRP2 7.2124 10.1889 4.846 3.1786
RERF-LC-MS CTRP2 7.2376 10.7578 4.5926 4.1468
NCI-H838 CTRP2 7.241 9.9669 4.9681 2.6688
HCC2108 CTRP2 7.2881 10.313 4.8361 3.12
SK-LU-1 CTRP2 7.3344 9.671 5.1599 1.8438
HCC44 CTRP2 7.3771 15.3604 2.445 12.4759
NCI-H1651 CTRP2 7.5064 9.3802 5.3797 0.9409
NCI-H2085 CTRP2 7.5314 18.1784 1.1677 16.7467
CAL-12T CTRP2 7.6208 16.8494 1.8928 14.1002
HCC78 CTRP2 7.6625 10.0113 5.1918 1.4167
NCI-H727 CTRP2 7.7418 12.4438 4.1247 5.3152
A-549 CTRP2 7.801 10.0667 5.2398 1.1489
RERF-LC-Ad2 CTRP2 7.81 9.2821 5.5564 0.3091
SBC-5 CTRP2 7.8123 21.1717 -0.1012 20.1277
HCC95 CTRP2 7.8258 15.9044 2.5087 11.5032
LC-1/sq-SF CTRP2 7.8974 9.0197 5.6836 0.0893
LCLC-103H CTRP2 8.0498 9.1819 5.682 0.0693
NCI-H460 CTRP2 8.0726 9.1673 5.6948 0.0562
Lu-65 CTRP2 8.237 10.0361 5.4492 0.3625
NCI-H2405 CTRP2 8.2398 12.3922 4.4598 3.4265
NCI-H1623 CTRP2 8.2585 10.1335 5.4216 0.4094
NCI-H650 CTRP2 8.3282 15.6424 2.9895 8.9218
NCI-H2030 CTRP2 8.3689 10.1324 5.4662 0.2875
NCI-H1792 CTRP2 8.4943 10.5283 5.3705 0.4224
NCI-H1299 CTRP2 8.6745 10.396 5.4878 0.1788
NCI-H322 CTRP2 12.0631 28.1659 -2.133 13.1992
Hs 888.Lu CTRP2 7.3025 9.8832 5.0446 2.3054
⏷ Show the Full List of 137 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 4.845 15.6647 0.2015 25.0493
OC 314 CTRP2 3.9354 5.1078 3.9153 14.1178
COV434 CTRP2 4.0785 5.8248 3.9547 13.5257
A2780 CTRP2 4.2445 5.197 4.231 12.0364
OVCAR-5 CTRP2 4.4624 5.3138 4.4496 10.5824
COV362 CTRP2 4.597 5.1733 4.5949 9.6497
TOV-112D CTRP2 4.7957 6.1298 4.6574 8.8057
OVK18 CTRP2 4.9174 5.8028 4.871 7.6672
TYK-nu CTRP2 5.1299 8.2775 4.0972 10.139
OAW28 CTRP2 5.1703 6.1599 5.0566 6.2261
SNU-119 CTRP2 5.1898 6.3965 4.9965 6.3935
TOV-21G CTRP2 5.2651 6.7422 3.5656 0.8238
HEY A8 CTRP2 5.3429 6.6402 5.0619 5.72
MCAS CTRP2 5.4615 7.5363 4.7705 6.5973
RMG-I CTRP2 5.5261 8.5373 4.3435 8.2169
EFO-27 CTRP2 5.6326 6.6511 5.3543 3.8076
ONCO-DG-1 CTRP2 5.6761 7.5937 4.9449 5.3854
Caov-3 CTRP2 5.6993 7.0188 5.2465 4.0853
OV56 CTRP2 5.7267 6.9695 3.68 0.2325
IGROV-1 CTRP2 5.7494 6.9907 5.3074 3.7184
JHOS-2 CTRP2 5.9195 6.9671 5.4753 2.6447
OAW42 CTRP2 5.9619 13.9878 0.5992 12.6619
Kuramochi CTRP2 6.0923 8.1124 5.05 4.0881
OVISE CTRP2 6.2439 19.3162 -0.426 23.8533
OV7 CTRP2 6.2621 7.9765 3.523 0.3573
COV644 CTRP2 6.2935 7.8727 5.3286 2.5607
OVCAR-4 CTRP2 6.3758 8.3236 5.1678 3.0923
SNU-8 CTRP2 6.3982 7.4822 5.5947 1.3068
EFO-21 CTRP2 6.5509 8.2494 5.3301 2.1539
OVCAR-8 CTRP2 6.7467 9.1868 5.013 3.1525
OVSAHO CTRP2 6.8426 8.6292 5.3412 1.7237
JHOM-1 CTRP2 7.4398 9.2165 5.415 0.8827
FU-OV-1 CTRP2 7.6634 9.757 5.3006 1.0659
SNU-840 CTRP2 7.8622 10.0301 5.2853 0.9668
OVTOKO CTRP2 8.2903 10.2051 5.4079 0.4252
JHOC-5 CTRP2 8.3364 9.535 5.6622 0.054
SK-OV-3 CTRP2 8.3739 13.0796 4.2264 4.1392
DOV13 CTRP2 8.4716 23.1119 -0.5606 20.2875
ES2 CTRP2 12.3534 30.0331 -1.1873 16.4981
OV-90 CTRP2 12.8747 26.103 0.9737 10.1314
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 4.8631 6.3536 4.6593 8.5997
P-STS CTRP2 6.334 8.2322 5.1815 3.1051
SYO-1 CTRP2 11.23 26.6988 -0.3463 15.7582
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 6.0454 8.5331 4.8009 5.2247
Yamato-SS CTRP2 6.1302 7.2938 5.4897 2.1712
TTC-709 CTRP2 3.9 7.1243 3.3407 16.3242
HT-1080 CTRP2 4.0717 4.9973 4.0639 13.1684
Rh41 CTRP2 4.202 5.8431 4.0849 12.6794
TE 441.T CTRP2 4.3445 5.7377 3.4655 2.4817
A-204 CTRP2 4.5149 6.8885 4.0875 11.7533
TE 617.T CTRP2 4.5996 6.2872 4.3952 10.3516
Rh18 CTRP2 4.6568 5.1068 4.6563 9.2458
Hs 729.T CTRP2 4.7564 5.7127 4.7135 8.7272
G-401 CTRP2 4.9824 6.2356 4.8281 7.6239
MES-SA CTRP2 4.9981 9.7232 1.9878 8.273
G-402 CTRP2 5.059 7.5531 3.082 3.0791
SK-LMS-1 CTRP2 5.1271 7.3594 3.2154 2.3898
GCT CTRP2 5.1573 6.6485 4.8637 6.9931
KYM-1 CTRP2 5.2028 6.2679 5.0565 6.131
RKN CTRP2 5.289 6.4871 5.0677 5.8441
BT-12 CTRP2 5.7823 6.4326 5.6042 2.4273
BT-16 CTRP2 6.4942 7.9196 5.45 1.752
Tm87-16 CTRP2 6.5843 15.5701 1.7236 16.5447
RD CTRP2 7.0027 9.115 5.2152 2.0119
SK-UT-1 CTRP2 7.4139 9.6419 5.2181 1.5562
SW982 CTRP2 7.5782 9.132 5.5149 0.51
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.8349 9.0807 5.6395 0.1572
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 4.7879 6.0712 4.6657 8.7995
NCI-H28 CTRP2 5.063 6.8409 4.6854 7.9415
MPP 89 CTRP2 5.1523 7.058 4.6844 7.7097
ACC-MESO-1 CTRP2 5.3811 9.4577 3.7578 10.9679
NCI-H2452 CTRP2 6.1502 8.1039 5.1015 3.7638
JL-1 CTRP2 7.6783 10.6642 4.9122 2.3788
IST-Mes1 CTRP2 8.4415 18.2734 0.2113 10.2961
NCI-H2052 CTRP2 8.4762 14.9089 3.438 7.0043
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 4.9119 11.1652 2.4882 17.1435
PaCa-3 CTRP2 5.1541 5.9453 5.0979 6.1257
DU145 CTRP2 5.4085 7.568 4.7043 6.9935
VCaP CTRP2 6.8437 8.6968 5.3104 1.8408
22Rv1 CTRP2 7.2463 13.8214 3.1065 10.1261
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 5.0178 8.0041 2.8397 4.2516
YD-15 CTRP2 5.7133 6.4292 5.5359 2.8764
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCC-StC-K140 CTRP2 0.0137 2.8989 -2.9937 3.7789
HGC-27 CTRP2 2.9499 4.6945 2.9183 20.7224
SNU-16 CTRP2 3.2031 4.9536 3.1593 19.0768
ECC10 CTRP2 3.5253 4.8438 3.5075 16.8425
GSS CTRP2 4.0433 5.3143 4.008 13.4509
SNU-1 CTRP2 4.2801 5.2649 4.2629 11.8119
MKN1 CTRP2 4.3593 6.0995 4.1901 11.8199
NCI-N87 CTRP2 4.8232 7.9118 3.9668 11.4159
Hs 746.T CTRP2 4.8331 6.9501 3.2197 2.7994
HuG1-N CTRP2 5.2512 7.4497 4.6062 7.7731
NUGC-3 CTRP2 5.2538 8.4444 4.1353 9.6925
LMSU CTRP2 5.3252 6.6002 5.0602 5.7741
SNU-5 CTRP2 5.4643 12.1178 2.5117 15.8369
KE-39 CTRP2 5.5017 8.3697 4.4034 8.022
SNU-216 CTRP2 5.6788 6.7643 5.3478 3.7196
SNU-601 CTRP2 6.003 7.143 5.4602 2.5364
SNU-668 CTRP2 6.0248 6.676 5.7121 1.4349
MKN74 CTRP2 6.265 8.5291 4.9808 4.0628
KATO III CTRP2 6.3257 39.8952 -10.6472 37.7579
SNU-620 CTRP2 6.3426 7.9066 5.3486 2.3971
MKN7 CTRP2 6.4757 9.2545 4.7831 4.5251
AGS CTRP2 6.5997 9.0711 4.9652 3.5704
Fu97 CTRP2 6.7305 10.2905 4.4624 5.4362
GSU CTRP2 6.7948 7.5882 5.7722 0.2836
SNU-719 CTRP2 7.0469 9.3469 5.1351 2.2651
MKN45 CTRP2 7.1181 8.3285 5.6247 0.4886
SH-10-TC CTRP2 7.4921 10.295 4.97 2.3689
23132/87 CTRP2 7.7649 9.0017 5.6412 0.1724
IM95 CTRP2 7.7864 12.6315 4.065 5.4899
NUGC-4 CTRP2 7.81 17.0662 1.9268 13.6654
ECC12 CTRP2 7.8261 8.7465 5.7511 0.0394
SNG-M CTRP2 5.805 7.2994 5.2077 4.0078
SNU-1077 CTRP2 6.9173 13.6361 2.9492 11.307
SNU-685 CTRP2 8.3913 9.6623 5.6384 0.0661
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
B-CPAP CTRP2 0.9486 3.325 0.9293 34.0127
SW579 CTRP2 4.7808 5.5124 4.7662 8.4673
8505C CTRP2 5.2188 11.4943 2.6041 16.0055
8305C CTRP2 6.0021 6.8592 5.6012 1.9462
FTC-238 CTRP2 6.0678 7.8491 3.491 0.5177
ML-1 [Human leukemia] CTRP2 6.3488 8.1042 5.2558 2.7714
TT2609-C02 CTRP2 6.5344 8.2072 3.5446 0.2298
BHT-101 CTRP2 6.8817 8.5044 5.4223 1.3726
FTC-133 CTRP2 6.9312 10.3098 4.598 4.5662
TT CTRP2 7.6899 13.6279 3.521 7.7822
CGTH-W-1 CTRP2 11.602 23.8341 1.2441 10.7247
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 -3.0189 25.6842 -12.0695 52.8994
HSC-2 CTRP2 3.2471 3.9909 3.1948 6.6461
SCC-25 CTRP2 4.112 8.5996 2.9384 17.3148
PE/CA-PJ34 (clone C12) CTRP2 4.6703 6.0399 4.546 9.5891
FaDu CTRP2 4.6882 7.2675 4.1147 11.1764
SCC-4 CTRP2 4.6905 6.6727 4.3579 10.2292
HSC-4 CTRP2 4.767 6.3488 4.5568 9.2613
PE/CA-PJ15 CTRP2 4.8641 5.9387 4.7835 8.1429
PE/CA-PJ41 (clone D2) CTRP2 5.2417 5.9368 5.1952 5.5082
SNU-1214 CTRP2 5.2678 10.7278 3.0277 14.2093
SNU-899 CTRP2 5.6852 9.3142 4.1013 8.887
CAL-33 CTRP2 5.7322 6.5976 5.4783 3.0594
CAL-27 CTRP2 5.818 7.309 3.5911 0.3908
BICR 6 CTRP2 5.8388 7.4266 5.1753 4.0705
SCC-9 CTRP2 5.8396 8.4525 3.1342 1.8796
SNU-46 CTRP2 5.983 7.137 5.4461 2.6361
YD-8 CTRP2 6.1589 7.8045 5.2579 3.0915
SNU-1076 CTRP2 6.3034 7.3396 5.5979 1.4321
BHY CTRP2 6.3684 7.8424 5.3991 2.1475
HSC-3 CTRP2 6.5715 14.9707 2.0126 15.5235
BICR 31 CTRP2 6.6173 10.8892 4.0813 7.2054
BICR 22 CTRP2 6.6366 8.6598 5.1912 2.5915
BICR 56 CTRP2 6.6783 8.408 5.34 1.9377
Detroit 562 CTRP2 6.914 13.7855 2.8726 11.616
BICR 16 CTRP2 7.2427 8.8029 5.4894 0.803
BICR 18 CTRP2 7.5033 9.5265 5.3163 1.1444
SNU-1066 CTRP2 8.3001 14.2032 3.6569 6.3965
PE/CA-PJ49 CTRP2 10.4102 24.0722 0.3582 14.8757
SNU-1041 CTRP2 11.3494 20.1338 2.7753 6.1022
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-1 CTRP2 2.8564 9.923 1.0709 27.4655
HT-1197 CTRP2 4.2319 5.3812 4.2002 12.1822
BC-3C CTRP2 4.4272 6.1851 3.3066 3.084
UM-UC-3 CTRP2 4.4804 5.7579 4.4064 10.674
T24 CTRP2 4.76 6.3692 3.4465 1.8846
U-BLC1 CTRP2 4.7672 6.077 4.6415 8.9498
JMSU-1 CTRP2 5.0901 7.7159 4.3231 9.3157
253J-BV CTRP2 5.1837 6.7304 4.8577 6.9446
647V CTRP2 5.2525 7.1597 3.3792 1.5435
KMBC-2 CTRP2 5.4749 7.0166 5.0288 5.5123
TCCSUP CTRP2 5.9106 7.2803 5.3116 3.3484
SW1710 CTRP2 5.9732 8.0953 4.959 4.7016
5637 CTRP2 6.1612 9.5074 4.4092 6.6507
SCaBER CTRP2 6.3852 7.8656 3.6094 0.1678
RT-4 CTRP2 6.4968 10.9455 3.9599 7.9203
HT-1376 CTRP2 6.5165 9.7785 4.5548 5.4069
KU-19-19 CTRP2 7.4565 17.3134 1.5391 15.6219
639V CTRP2 7.4879 8.6942 5.6444 0.2547
RT-112 CTRP2 7.6735 17.729 1.498 15.3938
J82 CTRP2 7.8552 11.4355 4.6667 3.0883
VM-CUB-1 CTRP2 8.3229 16.0422 2.7934 9.6732
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.3171 8.2828 5.7278 0.1575

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2785).
2 Evidence for tissue- and cell-type selective activation of the vitamin D receptor by Ro-26-9228, a noncalcemic analog of vitamin D3. J Cell Biochem. 2003 Feb 1;88(2):267-73.
3 Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility. IDrugs. 2009 Jun;12(6):381-93.