Details of the Drug

General Information of Drug (ID: DMPGIWT)

Drug Name

TB47

Synonyms

CHEMBL3612958; 1799682-71-5; 5-methoxy-2-methyl-~{N}-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide; 5-Methoxy-2-methyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)pyrazolo[1,5-a]pyridine-3-carboxamide; TB47; SCHEMBL19514093; HQECXZKIRDUGLC-UHFFFAOYSA-N; BDBM50598091; 5-methoxy-2-methyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidyl]phenyl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide; HV0

Indication

Disease Entry	ICD 11	Status	REF
Tuberculosis	1B10-1B14	Preclinical	[1]

Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C29H29F3N4O3
Canonical SMILES: CC1=NN2C=CC(=CC2=C1C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(C=C5)OC(F)(F)F)OC
InChI: InChI=1S/C29H29F3N4O3/c1-19-27(26-17-25(38-2)13-16-36(26)34-19)28(37)33-18-20-3-7-23(8-4-20)35-14-11-22(12-15-35)21-5-9-24(10-6-21)39-29(30,31)32/h3-10,13,16-17,22H,11-12,14-15,18H2,1-2H3,(H,33,37)
InChIKey: HQECXZKIRDUGLC-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 122188597
ChEBI ID: CHEMBL3612958
TTD ID: D5Q4NY

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cytochrome bc1 complex cytochrome b subunit (qcrB)	TT07X7W	QCRB_MYCTU	Inhibitor	[2]

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	The QcrB Inhibitors TB47 and Telacebec Do Not Potentiate the Activity of Clofazimine in Mycobacterium abscessus. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0096421.
2	The QcrB Inhibitors TB47 and Telacebec Do Not Potentiate the Activity of Clofazimine in Mycobacterium abscessus. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0096421.