Details of the Drug

General Information of Drug (ID: DMPIHN6)

Drug Name
AZD5582
Synonyms AZD 5582; AZD-5582
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 4 Molecular Weight (mw) 1015.3
Logarithm of the Partition Coefficient (xlogp) 5.9
Rotatable Bond Count (rotbonds) 19
Hydrogen Bond Donor Count (hbonddonor) 6
Hydrogen Bond Acceptor Count (hbondacc) 10
Chemical Identifiers
Formula
C58H78N8O8
IUPAC Name
(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-[(1S,2R)-2-[6-[[(1S,2R)-1-[[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-2,3-dihydro-1H-inden-2-yl]oxy]hexa-2,4-diynoxy]-2,3-dihydro-1H-inden-1-yl]pyrrolidine-2-carboxamide
Canonical SMILES
C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C(=O)N[C@@H]3[C@@H](CC4=CC=CC=C34)OCC#CC#CCO[C@@H]5CC6=CC=CC=C6[C@@H]5NC(=O)[C@@H]7CCCN7C(=O)[C@H](C8CCCCC8)NC(=O)[C@H](C)NC)NC
InChI
InChI=1S/C58H78N8O8/c1-37(59-3)53(67)61-49(39-21-9-7-10-22-39)57(71)65-31-19-29-45(65)55(69)63-51-43-27-15-13-25-41(43)35-47(51)73-33-17-5-6-18-34-74-48-36-42-26-14-16-28-44(42)52(48)64-56(70)46-30-20-32-66(46)58(72)50(40-23-11-8-12-24-40)62-54(68)38(2)60-4/h13-16,25-28,37-40,45-52,59-60H,7-12,19-24,29-36H2,1-4H3,(H,61,67)(H,62,68)(H,63,69)(H,64,70)/t37-,38-,45-,46-,47+,48+,49-,50-,51-,52-/m0/s1
InChIKey
WLMCRYCCYXHPQF-ZVMUOSSASA-N
Cross-matching ID
PubChem CID
49847690
TTD ID
D0VK7M

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cellular inhibitor of apoptosis 1 (BIRC2) TTQ5LRD BIRC2_HUMAN Antagonist [1]
Cellular inhibitor of apoptosis 2 (BIRC3) TTIRY6K BIRC3_HUMAN Antagonist [1]
XIAP messenger RNA (XIAP mRNA) TTK3WBU XIAP_HUMAN Antagonist [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 1.2692 5.6074 0.2133 26.2404
CHSA8926 GDSC1; GDSC2 -4.4702 1.116 -4.6971 70.3147
HuO-3N1 GDSC1; GDSC2 -0.5912 8.89 -3.1456 44.4324
EW-12 GDSC2 0.1628 11.8415 -3.7904 42.0639
H-EMC-SS GDSC1; GDSC2 0.5664 15.8287 -5.3539 42.3692
NOS-1 [Human HNSCC] GDSC1; GDSC2 0.9357 7.9102 -1.1728 33.452
ES1 GDSC1 1.1109 2.7655 1.0349 28.1203
HuO9 GDSC1; GDSC2 1.1231 5.3959 0.1544 27.1686
SK-PN-DW GDSC1; GDSC2 1.3834 4.1444 0.9361 21.8751
ES7 GDSC1; GDSC2 1.8717 3.6842 1.6273 15.8695
ES8 GDSC1; GDSC2 1.8858 3.0364 1.8223 14.7397
A-673 GDSC1; GDSC2 2.0868 2.9617 2.0525 12.5701
EW-3 GDSC1; GDSC2 2.1136 7.0696 0.3656 22.0932
EW-7 GDSC1; GDSC2 2.1184 3.2357 2.031 12.535
ES4 GDSC1; GDSC2 2.1561 6.6289 0.6188 20.5666
MHH-ES-1 GDSC1; GDSC2 2.1934 9.6812 -0.8411 27.3668
CAL-72 GDSC1; GDSC2 2.2102 3.2606 2.1248 11.6039
CAL-78 GDSC2 2.213 14.0895 -3.0118 33.8162
SaOS-2 GDSC1; GDSC2 2.2191 9.258 -0.6088 26.3297
ES6 GDSC1; GDSC2 2.2583 3.4412 2.1265 11.3753
CHSA0108 GDSC1; GDSC2 2.2669 3.7375 2.0353 11.8493
ES5 GDSC1; GDSC2 2.2737 5.0263 1.492 15.0332
EW-16 GDSC1; GDSC2 2.2778 3.53 2.1195 11.3273
HOS GDSC1; GDSC2 2.3094 3.2962 2.2239 10.61
EW-1 GDSC1; GDSC2 2.3141 3.4346 2.1893 10.778
TC-71 GDSC1; GDSC2 2.3877 3.1232 2.349 9.5747
G-292 clone A141B1 GDSC1; GDSC2 2.4011 3.2658 2.3317 9.604
EW-11 GDSC1; GDSC2 2.4631 5.6424 1.3863 14.9777
EW-22 GDSC1; GDSC2 2.4683 3.7517 2.2457 9.7889
EW-18 GDSC1; GDSC2 2.4984 3.3215 2.4233 8.6594
SK-ES-1 GDSC1; GDSC2 2.5451 3.2136 2.5011 8.0246
EW-24 GDSC1; GDSC2 2.5589 3.1029 2.5371 7.7689
EW-13 GDSC1; GDSC2 2.6283 3.8846 2.3615 8.4537
CHSA0011 GDSC1; GDSC2 2.7411 3.7732 2.526 7.0302
NY GDSC1; GDSC2 3.0353 7.2063 1.136 14.5803
U-CH2 GDSC2 3.1184 6.7648 1.4281 12.5495
SJSA-1 GDSC1 3.3679 5.3668 2.3375 7.5972
MG-63 GDSC1; GDSC2 4.1352 10.5763 0.3482 15.857
U2OS GDSC1; GDSC2 4.1989 6.5763 2.3547 3.9937
CADO-ES1 GDSC1; GDSC2 4.8826 6.5107 2.7645 0.8541
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 2.6322 3.5231 2.506 7.6039
RL GDSC1; GDSC2 -10.4886 2.1025 -11.4352 81.2029
CTV-1 GDSC1; GDSC2 -8.7775 -1.5247 -8.9423 86.8842
MHH-CALL-4 GDSC2 -8.4217 -4.1329 -8.4312 93.4284
SUP-M2 GDSC1; GDSC2 -7.7712 2.5514 -8.583 76.8915
NB4 GDSC1; GDSC2 -7.694 -2.3563 -7.7456 88.0696
MY-M12 GDSC2 -6.9195 2.9427 -7.7537 74.5238
ML-2 GDSC1; GDSC2 -6.738 -2.4164 -6.7615 86.9078
Karpas-299 GDSC1; GDSC2 -6.5593 -3.0596 -6.5657 88.5272
ALL-PO GDSC1; GDSC2 -5.7317 4.7193 -6.9727 68.7551
CCRF-CEM GDSC1; GDSC2 -5.1805 4.8243 -6.4068 66.9685
PL-21 GDSC1; GDSC2 -5.1769 4.0377 -6.158 68.0427
MOLM-13 GDSC1; GDSC2 -5.0959 0.0169 -5.2176 75.4024
Reh GDSC1; GDSC2 -4.6944 -1.1543 -4.7165 76.3345
KCL-22 GDSC1; GDSC2 -4.6333 2.6284 -5.1808 68.2779
JURL-MK1 GDSC1; GDSC2 -4.319 2.5393 -4.8169 67.1028
ALL-SIL GDSC1; GDSC2 -4.1928 -0.118 -4.2562 71.3309
H9 GDSC1; GDSC2 -4.0657 3.6158 -4.8226 64.4215
KY821 GDSC1; GDSC2 -3.4129 1.2007 -3.5763 64.3219
LAMA-84 GDSC1; GDSC2 -2.8352 12.7397 -7.1538 53.972
DEL GDSC1; GDSC2 -2.5111 2.0027 -2.7383 57.1176
DND-41 GDSC1; GDSC2 -2.2054 4.2613 -2.9907 53.7628
NOMO-1 GDSC1; GDSC2 -1.7036 3.5397 -2.2235 50.3363
CML-T1 GDSC1; GDSC2 -1.5361 3.5162 -2.0341 49.0079
L-540 GDSC1; GDSC2 -1.5139 4.2982 -2.2512 48.917
Kasumi-1 GDSC1; GDSC2 -1.4907 12.7217 -5.8118 49.3742
KE-37 GDSC1; GDSC2 -1.141 10.7594 -4.5523 47.7588
697 GDSC1; GDSC2 -0.8668 9.73 -3.8053 46.2224
GDM-1 GDSC1; GDSC2 -0.8573 3.8249 -1.3857 43.3833
DB GDSC1; GDSC2 -0.827 8.7154 -3.3051 45.6761
RPMI-8226 GDSC1; GDSC2 -0.6883 13.0929 -5.2067 46.3225
SU-DHL-6 GDSC1; GDSC2 -0.4804 2.8501 -0.709 39.0883
EHEB GDSC1 -0.4801 11.8798 -4.428 49.1557
MOLT-16 GDSC1; GDSC2 -0.4645 10.8641 -3.9331 44.6326
SR GDSC1; GDSC2 -0.4188 10.7583 -3.8386 44.3647
ME1 GDSC1; GDSC2 -0.4078 6.8744 -2.0657 42.0591
SU-DHL-5 GDSC1; GDSC2 -0.3369 0.0276 -0.3369 36.7165
NCI-H929 GDSC1; GDSC2 -0.3161 4.1023 -0.8859 38.7189
L-363 GDSC1; GDSC2 -0.2795 15.3663 -5.9135 45.3527
EoL-1 GDSC1; GDSC2 -0.2776 4.8854 -1.1217 39.2149
NK-92MI GDSC2 -0.051 1.8817 -0.0882 34.0311
TUR GDSC1; GDSC2 -0.0398 5.5524 -1.1285 37.9377
Loucy GDSC1; GDSC2 -0.0273 3.99 -0.5352 35.849
MV4-11 GDSC1 0.0767 1.4662 0.0693 40.6074
KOPN-8 GDSC1; GDSC2 0.0857 7.472 -1.8218 39.1117
KMOE-2 GDSC1; GDSC2 0.1119 3.531 -0.2405 33.879
AMO1 GDSC1; GDSC2 0.246 1.4178 0.2426 30.8844
BE-13 GDSC1; GDSC2 0.2555 6.9689 -1.4247 37.2975
OCI-Ly7 GDSC1; GDSC2 0.385 3.9904 -0.0878 31.789
SCC-3 GDSC2 0.3886 1.6852 0.3804 29.4775
SU-DHL-1 GDSC2 0.4075 2.9842 0.2268 30.1596
Karpas-45 GDSC1; GDSC2 0.4336 1.5358 0.4305 29.0001
MHH-CALL-2 GDSC1; GDSC2 0.4827 2.0833 0.4537 28.6385
JVM-3 GDSC1; GDSC2 0.5463 2.8033 0.4171 28.513
MLMA GDSC1; GDSC2 0.6911 1.687 0.6883 26.4146
L-428 GDSC1; GDSC2 0.7053 7.0199 -0.9913 33.8558
WSU-NHL GDSC1; GDSC2 0.7399 1.7467 0.7366 25.9276
NALM-6 GDSC1; GDSC2 0.7875 1.9069 0.7805 25.468
MM1.S GDSC2 0.8002 14.4907 -4.4819 40.7243
KG-1 GDSC2 0.8041 12.7093 -3.6058 39.5141
ST486 GDSC1; GDSC2 0.8254 2.7827 0.7234 25.577
Namalwa GDSC1; GDSC2 0.866 2.7089 0.7808 25.0828
P30/OHK GDSC1; GDSC2 0.9059 2.3787 0.8704 24.425
TALL-1 [Human adult T-ALL] GDSC2 0.9059 2.8103 0.8052 24.7633
OCI-AML-3 GDSC1; GDSC2 0.9496 9.3332 -1.8337 35.3583
SUP-B15 GDSC2 1.1002 10.0626 -2.0412 35.3054
EM-2 GDSC1; GDSC2 1.1191 16.6147 -5.2391 40.6438
CTB-1 GDSC1; GDSC2 1.1823 3.7719 0.8501 23.2397
SU-DHL-16 GDSC1; GDSC2 1.2326 3.3004 1.0476 21.9383
MOLM-16 GDSC1; GDSC2 1.2652 10.3394 -2.02 34.6213
JVM-2 GDSC1; GDSC2 1.3573 2.5946 1.3239 19.8856
Karpas-422 GDSC1; GDSC2 1.4124 2.5726 1.3847 19.3031
RPMI-6666 GDSC1; GDSC2 1.419 3.6221 1.1561 20.4981
VL51 GDSC1; GDSC2 1.4623 3.2543 1.3105 19.458
BL-41 GDSC1; GDSC2 1.534 2.2404 1.5316 17.954
Jiyoye GDSC1; GDSC2 1.5488 2.9688 1.4706 18.1977
U-698-M GDSC1; GDSC2 1.5654 2.8483 1.5104 17.9097
MOLT-13 GDSC1; GDSC2 1.5782 14.2619 -3.6615 37.0665
SU-DHL-10 GDSC1; GDSC2 1.6245 3.4212 1.4415 18.0031
MC116 GDSC1; GDSC2 1.6471 5.9001 0.4648 23.365
P12-Ichikawa GDSC1; GDSC2 1.653 7.5855 -0.3217 27.2024
CRO-AP2 GDSC1; GDSC2 1.6615 3.4736 1.4663 17.6992
Karpas-620 GDSC1; GDSC2 1.7559 10.2895 -1.5398 31.4157
THP-1 GDSC1; GDSC2 1.7577 3.2884 1.6238 16.4012
BV-173 GDSC1 1.7634 3.1089 1.6742 20.059
SKM-1 GDSC1; GDSC2 1.77 3.36 1.6177 16.3783
DoHH2 GDSC2 1.7749 5.3851 0.8275 20.8563
EB2 GDSC1; GDSC2 1.8051 3.0846 1.7248 15.6387
Sc-1 GDSC1 1.8397 2.9035 1.7963 18.8052
HH [Human lymphoma] GDSC1; GDSC2 1.8543 3.8881 1.5365 16.4573
GA-10 GDSC1; GDSC2 1.8571 3.5738 1.6481 15.8181
SUP-B8 GDSC1; GDSC2 1.8789 3.379 1.7311 15.2626
Mono-Mac-6 GDSC1 1.9064 4.4168 1.3842 21.2832
PF-382 GDSC1; GDSC2 1.9139 4.9169 1.1776 18.2894
Karpas-1106P GDSC1; GDSC2 1.9333 3.3119 1.8092 14.5886
GR-ST GDSC1; GDSC2 1.9773 4.3553 1.484 16.2445
SU-DHL-4 GDSC1; GDSC2 1.987 3.0615 1.9271 13.706
NU-DUL-1 GDSC1; GDSC2 2.0137 3.1821 1.9299 13.5653
Ramos.2G6.4C10 GDSC1; GDSC2 2.0211 3.2746 1.9149 13.6117
L-1236 GDSC1; GDSC2 2.0217 12.8337 -2.5567 33.3486
RCH-ACV GDSC1; GDSC2 2.0361 13.9707 -3.1086 34.5709
MHH-PREB-1 GDSC1; GDSC2 2.0418 3.411 1.8995 13.6007
K-562 GDSC1; GDSC2 2.0734 3.3056 1.9638 13.1057
HL-60 GDSC1; GDSC2 2.082 3.238 1.9907 12.9211
KMS-12-BM GDSC2 2.082 3.1731 2.0063 12.8371
RPMI-8866 GDSC2 2.1364 3.4238 1.999 12.6267
U266B1 GDSC1; GDSC2 2.179 11.111 -1.5618 30.0032
WIL2 NS GDSC1; GDSC2 2.1869 3.0825 2.1394 11.6353
Raji GDSC1; GDSC2 2.2043 3.0032 2.1722 11.3802
HDLM-2 GDSC1; GDSC2 2.2114 3.3753 2.095 11.7607
RPMI-8402 GDSC1 2.22 3.1167 2.1685 14.1061
P31/FUJ GDSC1 2.2239 2.8771 2.2095 13.8167
A3/Kawakami GDSC1; GDSC2 2.2262 3.0846 2.1816 11.2257
LC4-1 GDSC1; GDSC2 2.2272 3.5405 2.0611 11.877
HC-1 GDSC1; GDSC2 2.2334 3.2045 2.1639 11.2862
BC-1 GDSC1; GDSC2 2.2459 3.203 2.1778 11.1533
RS4;11 GDSC1; GDSC2 2.2462 3.2959 2.155 11.2747
CA46 GDSC1; GDSC2 2.262 3.2222 2.1909 11.0076
SUP-HD1 GDSC1; GDSC2 2.2718 3.3335 2.1726 11.0613
P32/ISH GDSC1; GDSC2 2.3188 3.0462 2.2883 10.2232
SUP-T1 GDSC1; GDSC2 2.3413 3.2765 2.2638 10.2475
NKM-1 GDSC1 2.3913 3.3299 2.3041 12.2059
Granta-519 GDSC1; GDSC2 2.4009 3.2701 2.3305 9.6116
BALL-1 GDSC1; GDSC2 2.4055 12.6278 -2.1152 30.9456
ROS-50 GDSC1; GDSC2 2.428 4.7487 1.7737 12.7522
JeKo-1 GDSC1; GDSC2 2.4343 3.1819 2.3876 9.1497
A4/Fukuda GDSC1; GDSC2 2.4373 3.1165 2.4038 9.0499
IM-9 GDSC1; GDSC2 2.4548 3.4228 2.3463 9.2796
ARH-77 GDSC1; GDSC2 2.4567 3.5554 2.305 9.5016
KMS-11 GDSC1; GDSC2 2.459 3.4329 2.3477 9.2527
CESS GDSC1; GDSC2 2.4606 3.3124 2.3845 9.0441
BC-3 GDSC2 2.4762 3.9251 2.1852 10.1071
BONNA-12 GDSC2 2.5576 3.7576 2.3385 8.8791
EJM GDSC1; GDSC2 2.5658 3.5991 2.4074 8.449
KM-H2 GDSC1; GDSC2 2.5664 12.1552 -1.7391 29.3003
Karpas-231 GDSC1; GDSC2 2.5696 3.2915 2.509 7.8682
MEG-01 GDSC1; GDSC2 2.5864 5.1943 1.7193 12.5042
VAL GDSC1; GDSC2 2.5948 3.8706 2.3323 8.7619
SU-DHL-8 GDSC1; GDSC2 2.628 3.2446 2.5843 7.1913
MOLP-8 GDSC1; GDSC2 2.631 3.4078 2.5428 7.4038
Hs 445 GDSC1; GDSC2 2.6702 3.3864 2.5921 6.9551
OCI-Ly19 GDSC1; GDSC2 2.7034 3.6354 2.5413 7.0978
OCI-AML-2 GDSC1; GDSC2 2.7756 10.0265 -0.4959 23.9544
Ku812 GDSC1; GDSC2 2.8193 9.4253 -0.1582 22.2711
TK [Human B-cell lymphoma] GDSC1; GDSC2 2.8595 3.8195 2.6292 5.9468
SIG-M5 GDSC2 2.8876 3.5761 2.7605 5.0602
Farage GDSC1; GDSC2 2.9114 8.4336 0.4164 19.0683
OCI-AML-5 GDSC1; GDSC2 2.951 5.2779 2.0199 9.3886
MOLT-4 GDSC1; GDSC2 3.0582 4.4986 2.5016 6.0154
SK-MM-2 GDSC1; GDSC2 3.0814 4.6817 2.4325 6.3721
DG-75 GDSC1; GDSC2 3.136 16.1529 -3.2492 31.7108
Daudi GDSC1; GDSC2 3.1523 4.7762 2.4491 6.0402
MN-60 GDSC1; GDSC2 3.1668 10.9486 -0.6215 23.2617
RC-K8 GDSC1; GDSC2 3.2813 7.7534 1.0722 14.2071
OPM-2 GDSC1; GDSC2 3.2953 4.8475 2.5369 5.0484
LP-1 GDSC1; GDSC2 3.3491 4.5423 2.7342 3.6428
ATN-1 GDSC1; GDSC2 3.4182 4.7514 2.6858 3.7565
JSC-1 GDSC1; GDSC2 3.5314 8.9819 0.6645 15.8176
CMK GDSC1 3.564 5.7614 2.2976 7.2404
OCI-M1 GDSC1; GDSC2 3.5848 7.6041 1.3957 11.3844
QIMR-WIL GDSC1; GDSC2 3.6958 5.6357 2.4599 4.4623
HAL-01 GDSC1; GDSC2 4.0363 6.4508 2.3054 4.6313
YT GDSC1 4.0966 7.449 1.863 8.9253
JJN-3 GDSC1; GDSC2 4.3505 16.2382 -2.3003 26.0298
WSU-DLCL2 GDSC1 4.3552 10.6206 0.4939 17.3603
HT GDSC1; GDSC2 4.7124 16.4104 -2.1027 24.5271
HEL GDSC1; GDSC2 5.0026 6.3129 2.891 0.3471
Jurkat GDSC1; GDSC2 5.7781 28.819 -7.442 33.252
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FLO-1 GDSC1; GDSC2 -7.2504 9.9774 -10.5299 66.6129
ESO-26 GDSC1; GDSC2 -5.5308 3.6393 -6.4279 69.7607
HCE-4 GDSC1; GDSC2 -4.9474 -3.3714 -4.9474 82.3366
KYAE-1 GDSC1; GDSC2 -3.1547 35.9646 -18.6679 52.0832
KYSE-220 GDSC1; GDSC2 0.747 3.8129 0.3639 27.8234
OACP4 C GDSC1; GDSC2 1.8212 3.9552 1.4761 16.9431
OACM5.1 C GDSC1; GDSC2 2.3404 12.0612 -1.8904 30.4952
SK-GT-4 GDSC1; GDSC2 3.5867 5.3792 2.5048 4.4534
TE-12 GDSC1; GDSC2 4.246 7.025 2.1724 4.9872
ESO-51 GDSC1; GDSC2 4.9761 19.9154 -3.6398 28.1428
KYSE-50 GDSC1; GDSC2 5.3416 11.9412 0.5572 11.8789
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 0.9357 2.5268 0.884 24.2099
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-14 GDSC1; GDSC2 1.6512 3.37 1.4853 17.6421
GOTO GDSC1; GDSC2 1.7345 2.9174 1.6808 16.2062
KP-N-YN GDSC1; GDSC2 1.9921 3.5199 1.8121 14.3068
NB1 GDSC1 2.1488 2.8582 2.1322 14.7694
GI-ME-N GDSC1; GDSC2 2.268 3.4087 2.1469 11.2192
KP-N-RT-BM-1 GDSC2 2.2938 4.1409 1.9047 12.4936
IMR-5 GDSC1; GDSC2 2.5957 3.2979 2.5358 7.6024
CHP-126 GDSC1; GDSC2 2.8005 3.7473 2.599 6.3606
CHP-134 GDSC2 2.8351 4.0783 2.4883 6.8881
SJNB-17 GDSC1; GDSC2 3.0325 4.3071 2.5713 5.6666
Kelly GDSC1; GDSC2 3.382 4.6103 2.7271 3.5952
SK-N-MC-IXC GDSC1; GDSC2 3.5485 5.8019 2.2653 6.0594
SJNB-7 GDSC1; GDSC2 3.5899 7.4168 1.4933 10.773
SJNB-13 GDSC1; GDSC2 3.6299 10.2764 0.0979 18.5349
SK-N-AS GDSC1; GDSC2 3.6471 12.1185 -0.8084 22.6275
SK-N-BE(2)-M17 GDSC1; GDSC2 3.6656 5.8855 2.3141 5.4488
KP-N-YS GDSC2 3.7335 6.2708 2.1749 6.1486
SJNB-12 GDSC1 3.8884 6.0153 2.4131 5.3556
NB69 GDSC1; GDSC2 3.9518 6.896 2.0288 6.5234
CHP-212 GDSC2 4.0196 8.0498 1.5113 9.5337
SK-N-DZ GDSC1; GDSC2 4.4325 14.5039 -1.3726 22.7152
SiMa GDSC1; GDSC2 4.6588 6.7675 2.5444 2.136
LA-N-6 GDSC1; GDSC2 4.7367 7.0067 2.4822 2.3486
SJNB-10 GDSC1; GDSC2 4.7782 6.9962 2.5095 2.1487
SJNB-5 GDSC1; GDSC2 4.8389 8.9539 1.6477 6.8756
SK-N-SH GDSC1 4.8775 7.0141 2.5544 2.2353
MHH-NB-11 GDSC2 5.2294 6.8894 2.7686 0.5839
SJNB-6 GDSC1; GDSC2 5.286 6.8669 2.8001 0.4564
NH-12 GDSC1; GDSC2 5.4148 7.5119 2.6086 1.0133
SK-N-FI GDSC1 5.5675 7.2509 2.7707 0.4977
NB(TU)1 GDSC1; GDSC2 5.793 7.3697 2.8132 0.2265
TGW GDSC1; GDSC2 6.0061 7.6703 2.7861 0.2165
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 -0.3385 4.7066 -1.1211 39.559
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Evsa-T GDSC1; GDSC2 -7.7824 -3.2466 -7.8013 90.6738
HCC70 GDSC1; GDSC2 -6.7741 4.0058 -7.8903 72.4452
BT-549 GDSC1; GDSC2 -3.0556 7.5617 -5.1244 56.6039
CAL-85-1 GDSC1; GDSC2 -2.8418 6.0956 -4.3236 56.4389
MCF-7 GDSC1; GDSC2 -2.7497 22.104 -11.5091 52.3672
HDQ-P1 GDSC1; GDSC2 -2.6691 2.884 -3.102 57.6027
HCC38 GDSC1; GDSC2 -2.5283 10.3919 -5.7837 53.4779
EFM-19 GDSC1; GDSC2 -0.6212 17.6936 -7.3665 46.9758
EFM-192A GDSC1; GDSC2 -0.5593 145.6268 -71.0902 49.5864
HCC1954 GDSC1; GDSC2 -0.4039 15.1735 -5.937 45.7521
MRK-nu-1 GDSC1; GDSC2 -0.2104 91.7123 -43.8503 49.1345
HCC1187 GDSC1; GDSC2 -0.1329 17.464 -6.8007 45.3919
MDA-MB-415 GDSC1; GDSC2 0.1963 28.3584 -11.8878 46.4291
OCUB-M GDSC1; GDSC2 0.4193 15.3395 -5.2493 42.7184
MDA-MB-468 GDSC1; GDSC2 0.5205 16.0526 -5.5061 42.6421
HCC1806 GDSC1; GDSC2 1.4117 5.5479 0.3853 24.7528
HCC1500 GDSC1; GDSC2 1.6015 12.5706 -2.8042 35.3083
MDA-MB-453 GDSC1; GDSC2 1.7459 9.9942 -1.4041 31.0136
HCC1143 GDSC1; GDSC2 1.9478 10.0874 -1.2647 29.8106
MDA-MB-330 GDSC1; GDSC2 2.02 15.055 -3.662 35.726
HCC1419 GDSC1; GDSC2 2.0636 5.4755 1.0756 18.3032
YMB-1-E GDSC2 2.1209 4.9723 1.3634 16.3852
HCC1569 GDSC1; GDSC2 2.186 4.6171 1.5882 14.7952
HCC202 GDSC1 2.2059 3.6604 1.9972 15.3568
HCC1599 GDSC1; GDSC2 2.2293 13.8038 -2.8552 33.4088
COLO 824 GDSC1; GDSC2 2.3204 4.3161 1.8579 12.6631
HCC1937 GDSC1; GDSC2 2.387 3.5779 2.2218 10.2739
AU565 GDSC1; GDSC2 2.4584 3.5096 2.3223 9.3968
CAMA-1 GDSC1; GDSC2 2.5038 12.8132 -2.1217 30.6542
T-47D GDSC1; GDSC2 2.5793 3.4378 2.4771 7.9987
BT-474 GDSC1; GDSC2 2.605 3.7122 2.4067 8.2864
HCC1395 GDSC1 2.7127 4.043 2.3804 9.9732
HCC2218 GDSC1; GDSC2 2.7252 4.1748 2.334 8.2378
HCC2157 GDSC1; GDSC2 2.968 4.6559 2.3411 7.322
JIMT-1 GDSC1; GDSC2 3.023 5.3363 2.0559 8.9286
Hs 578T GDSC1; GDSC2 3.1868 4.6353 2.5495 5.2981
ZR-75-30 GDSC1; GDSC2 3.5339 11.776 -0.7297 22.6256
MDA-MB-231 GDSC1; GDSC2 3.669 5.3305 2.5902 3.7165
DU4475 GDSC1; GDSC2 3.6712 6.4357 2.0457 7.1169
CAL-51 GDSC1; GDSC2 3.9319 14.5539 -1.7941 25.5034
UACC-893 GDSC1; GDSC2 3.9415 11.7044 -0.3648 19.8728
HCC1428 GDSC1; GDSC2 4.1317 8.1034 1.5679 8.9147
MDA-MB-157 GDSC1; GDSC2 4.2302 7.4792 1.9429 6.4079
MDA-MB-361 GDSC1; GDSC2 4.6122 6.544 2.6166 1.83
MDA-MB-175-VII GDSC1 4.7275 6.3638 2.7514 1.3128
BT-483 GDSC1 5.3328 6.9464 2.7895 0.5754
MFM-223 GDSC1; GDSC2 5.9161 13.9254 -0.0047 13.4591
CAL-120 GDSC1; GDSC2 6.0334 19.5039 -2.6356 23.2043
MDA-MB-436 GDSC1; GDSC2 7.2609 18.8499 -1.4555 16.8687
BT-20 GDSC1; GDSC2 8.0982 20.2218 -1.5562 15.7449
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MG-1 GDSC1; GDSC2 -7.6154 8.4475 -10.3217 68.6942
Daoy GDSC1; GDSC2 -2.0448 5.4982 -3.2459 52.3906
YKG-1 GDSC1; GDSC2 -0.8454 153.2549 -75.145 49.7095
8-MG-BA GDSC1; GDSC2 -0.015 12.7337 -4.3892 43.3525
D-423MG GDSC1; GDSC2 0.1505 8.6957 -2.3146 39.8508
M059J GDSC1; GDSC2 0.6776 25.7768 -10.1788 44.9791
PFSK-1 GDSC1; GDSC2 1.3268 3.9369 0.9503 22.0448
42-MG-BA GDSC1; GDSC2 2.0772 3.0403 2.0288 12.7407
SF539 GDSC1; GDSC2 2.1837 14.1387 -3.062 34.017
GI-1 GDSC1; GDSC2 2.2626 3.1499 2.2079 10.9141
Onda 10 GDSC1; GDSC2 2.3978 5.4462 1.4173 15.0245
ONS-76 GDSC1; GDSC2 2.5418 3.1683 2.5071 8.0081
DK-MG GDSC1; GDSC2 2.5884 5.0796 1.776 12.1487
D-263MG GDSC1; GDSC2 2.6711 3.5603 2.5348 7.2728
SF268 GDSC1; GDSC2 2.6874 3.4617 2.5868 6.9085
A-172 GDSC1; GDSC2 2.6883 3.3421 2.6249 6.6935
KINGS-1 GDSC1; GDSC2 2.7771 3.6928 2.5968 6.4691
D283 Med GDSC1; GDSC2 2.8017 3.6436 2.6427 6.1006
SNB-75 GDSC1; GDSC2 2.8877 3.7456 2.6903 5.4718
D-336MG GDSC1; GDSC2 3.0355 5.0777 2.1953 8.0119
KALS-1 GDSC1; GDSC2 3.1215 40.5067 -15.4377 43.0679
D-245MG GDSC2 3.1674 5.1421 2.2801 7.0598
LN-405 GDSC1; GDSC2 3.2137 13.876 -2.0456 28.2978
LN-229 GDSC1; GDSC2 3.2519 4.3314 2.7577 3.781
SW1783 GDSC1 3.271 18.025 -4.0721 36.0833
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 3.2722 4.7473 2.5674 4.924
MOG-G-UVW GDSC1 3.36 6.4344 1.7973 11.8312
D-566MG GDSC1; GDSC2 3.467 22.3846 -6.0888 35.8954
U-251MG GDSC1; GDSC2 3.4687 7.049 1.5793 10.5811
D-392MG GDSC1; GDSC2 3.5826 5.4024 2.4902 4.555
U-87MG ATCC GDSC1; GDSC2 3.6581 6.0218 2.2409 5.9268
LNZTA3WT4 GDSC1 3.668 7.6213 1.4534 13.3132
Becker GDSC1; GDSC2 3.8175 5.1769 2.7678 2.3022
GaMG GDSC1; GDSC2 3.9487 5.4985 2.7011 2.4383
D-542MG GDSC1; GDSC2 3.9782 6.0662 2.4507 3.875
MOG-G-CCM GDSC1 3.9896 6.2958 2.348 5.5701
D-502MG GDSC1; GDSC2 4.1566 6.6897 2.2726 4.5723
KNS-81-FD GDSC1; GDSC2 4.2408 7.4165 1.9806 6.1558
NMC-G1 GDSC1; GDSC2 4.317 5.9338 2.7224 1.6985
SF295 GDSC1; GDSC2 4.3619 7.459 2.0428 5.522
Hs 683 GDSC1; GDSC2 4.3891 10.1691 0.7419 13.0871
U-118MG GDSC1; GDSC2 4.4151 13.007 -0.6424 19.842
SW1088 GDSC1; GDSC2 4.4799 6.5809 2.5264 2.502
CAS-1 GDSC1; GDSC2 4.6796 6.6475 2.6078 1.7843
H4 GDSC1; GDSC2 4.8224 8.651 1.7801 6.1403
KNS-42 GDSC1; GDSC2 5.2062 14.687 -0.8769 18.8896
T98G GDSC1; GDSC2 5.2409 10.1055 1.365 7.6925
DBTRG-05MG GDSC1; GDSC2 5.3074 7.175 2.6926 0.7876
SF126 GDSC1; GDSC2 5.348 7.0571 2.7545 0.5567
LN-18 GDSC1; GDSC2 5.5211 18.0127 -2.281 23.223
GB-1 GDSC1; GDSC2 5.6018 7.4215 2.7219 0.5136
AM-38 GDSC1; GDSC2 5.873 16.1746 -1.1224 18.3805
D-247MG GDSC1; GDSC2 5.9698 8.128 2.6085 0.6436
Onda 11 GDSC1; GDSC2 6.4452 16.2474 -0.7596 15.7282
YH-13 GDSC1; GDSC2 6.6443 20.5683 -2.7137 22.201
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1; GDSC2 2.9514 11.869 -1.2641 26.4714
TGBC24TKB GDSC1; GDSC2 4.3061 6.7318 2.3509 3.806
TGBC1TKB GDSC1 5.0049 12.8754 -0.1352 18.8384
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC1; GDSC2 -7.4807 -3.8283 -7.4857 92.1415
MFE-280 GDSC1; GDSC2 2.6683 5.3122 1.7407 12.084
AN3-CA GDSC1; GDSC2 2.6965 6.4839 1.1936 15.3349
EN GDSC1; GDSC2 2.7542 3.7392 2.5538 6.814
RL95-2 GDSC1; GDSC2 3.1531 13.0474 -1.6822 27.3169
MFE-296 GDSC1; GDSC2 3.929 6.1129 2.3943 4.3252
MFE-319 GDSC1; GDSC2 4.2802 10.9627 0.2678 15.8944
KLE GDSC1; GDSC2 4.5957 12.6868 -0.346 18.0666
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-195 GDSC1; GDSC2 -3.5155 -0.4013 -3.5381 67.2431
KTCTL-140 GDSC1; GDSC2 -2.0102 1.3115 -2.0966 53.2562
SW13 GDSC1; GDSC2 1.0009 5.5633 -0.044 28.6689
RXF 393L GDSC1; GDSC2 2.4236 3.6518 2.2352 10.0396
786-O GDSC1; GDSC2 2.5941 3.6325 2.4255 8.225
BFTC-909 GDSC1; GDSC2 3.0258 5.1516 2.15 8.328
TK-10 GDSC1; GDSC2 3.4816 5.7282 2.2492 6.3414
769-P GDSC1; GDSC2 3.6007 5.1714 2.618 3.7094
HA7-RCC GDSC1; GDSC2 3.8183 8.9752 0.8975 13.695
NCC010 GDSC1; GDSC2 3.8564 7.0247 1.8949 7.5855
A-498 GDSC1; GDSC2 4.1958 8.2643 1.5358 8.9545
KMRC-20 GDSC1; GDSC2 4.3527 15.9379 -2.149 25.559
RCC10RGB GDSC1; GDSC2 4.4682 6.2834 2.6521 1.8477
ACHN GDSC1; GDSC2 4.8049 8.3333 1.918 5.376
KTCTL-26A GDSC1; GDSC2 4.9497 6.7726 2.6905 1.0952
KTCTL-1M GDSC1; GDSC2 5.0142 8.1674 2.1219 3.8573
VMRC-RCZ GDSC1; GDSC2 5.0527 7.238 2.5489 1.6135
SW156 GDSC1; GDSC2 5.1148 9.6271 1.5089 7.1259
CAL-54 GDSC1; GDSC2 5.1236 9.4982 1.5751 6.7334
KTCTL-13 GDSC1; GDSC2 5.3587 8.1138 2.3349 2.2623
SN12C GDSC1; GDSC2 5.5548 7.4224 2.7026 0.5954
KMRC-1 GDSC1 5.5781 7.2512 2.7747 0.4795
OS-RC-2 GDSC1; GDSC2 5.5818 7.2478 2.7773 0.3769
LB2241-RCC GDSC1; GDSC2 5.6063 7.4141 2.7264 0.4987
BB65-RCC GDSC1; GDSC2 5.6159 8.214 2.4203 1.5929
UO-31 GDSC1; GDSC2 5.6316 7.5986 2.6681 0.6561
A-704 GDSC1; GDSC2 5.7374 7.7925 2.6389 0.6839
LB996-RCC GDSC1; GDSC2 5.8652 8.0535 2.5936 0.7488
LB1047-RCC GDSC1; GDSC2 5.9083 7.9289 2.6573 0.5382
NCC021 GDSC1; GDSC2 5.9114 7.951 2.6504 0.5554
VMRC-RCW GDSC2 5.929 7.3182 2.8786 0.1019
KTCTL-21 GDSC1; GDSC2 6.2444 8.3832 2.6233 0.4736
Caki-1 GDSC1; GDSC2 7.379 15.5951 0.1463 10.0512
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-C2B GDSC1; GDSC2 -0.9852 22.9689 -10.2872 48.478
SW1463 GDSC1; GDSC2 0.3214 20.4259 -7.8435 44.7338
LS1034 GDSC1; GDSC2 1.1119 6.0909 -0.1616 28.7236
HT-29 GDSC1; GDSC2 1.8181 3.9145 1.4878 16.8897
LS123 GDSC1; GDSC2 1.9248 17.4658 -4.9456 38.0525
HCC2998 GDSC1; GDSC2 1.9555 8.5452 -0.5006 26.8269
SNU-175 GDSC2 2.1181 4.8508 1.4152 16.0887
COLO205 GDSC1; GDSC2 2.2121 3.021 2.1776 11.3143
MDST8 GDSC1; GDSC2 2.586 3.1361 2.5609 7.5142
HCT 116 GDSC1; GDSC2 2.588 3.6983 2.394 8.4315
SNU-1040 GDSC1; GDSC2 2.7192 3.2967 2.6709 6.3017
KM12 GDSC1; GDSC2 2.8963 4.842 2.1835 8.5489
SW48 GDSC1; GDSC2 2.9276 3.8933 2.6655 5.4655
SNU-283 GDSC2 2.9768 4.2534 2.5445 6.0268
NCI-H747 GDSC1; GDSC2 3.1209 6.3371 1.6437 11.206
HT-55 GDSC1; GDSC2 3.1368 4.2019 2.7196 4.3883
SW620 GDSC1; GDSC2 3.2718 4.4268 2.7271 3.9143
LS411N GDSC1; GDSC2 3.3116 5.1577 2.3955 5.8958
SW626 GDSC1; GDSC2 3.3326 5.6139 2.1848 7.1679
COLO 678 GDSC1; GDSC2 3.3746 5.1801 2.4364 5.4554
SNU-C1 GDSC1; GDSC2 3.4264 5.156 2.4904 4.9686
SK-CO-1 GDSC1; GDSC2 3.7069 5.3786 2.5941 3.6025
NCI-H508 GDSC1; GDSC2 3.7197 5.0545 2.7605 2.551
CaR-1 GDSC1; GDSC2 3.7707 5.7566 2.4553 4.3118
RCM-1 [Human ESC] GDSC1; GDSC2 3.8044 15.6955 -2.4676 27.9199
NCI-H716 GDSC1; GDSC2 3.8511 6.9716 1.9172 7.4604
SNU-C5 GDSC1; GDSC2 3.8525 15.0576 -2.1098 26.7292
SNU-407 GDSC1; GDSC2 3.8548 6.7783 2.0152 6.8422
C2BBe1 GDSC1; GDSC2 3.9849 6.688 2.1543 5.6713
RKO GDSC1; GDSC2 4.004 35.1746 -12.0397 40.2444
LS180 GDSC1; GDSC2 4.2467 15.7025 -2.1156 25.7224
LoVo GDSC1; GDSC2 4.3119 8.6249 1.4434 9.232
SNU-61 GDSC1; GDSC2 4.474 9.897 0.9381 11.7835
GP5d GDSC1; GDSC2 4.529 6.8778 2.4208 3.0046
HT115 GDSC1; GDSC2 4.7153 9.5904 1.2592 9.3892
SW948 GDSC1; GDSC2 4.7784 10.8428 0.6954 12.4048
COLO 320HSR GDSC1; GDSC2 4.8694 7.0292 2.5437 1.8571
LS513 GDSC1; GDSC2 4.8719 6.3911 2.8068 0.7009
SW837 GDSC1; GDSC2 4.9763 17.8973 -2.6371 25.5236
SNU-81 GDSC1; GDSC2 5.0858 15.6224 -1.4273 21.3161
T84 GDSC1; GDSC2 5.2321 10.5087 1.1687 8.8063
CW-2 GDSC1; GDSC2 5.6829 7.6378 2.6745 0.6074
SW1417 GDSC1; GDSC2 5.8197 14.5052 -0.3497 15.251
SW1116 GDSC1; GDSC2 5.86 17.5573 -1.8073 20.9262
DiFi GDSC1; GDSC2 6.1785 18.626 -2.0998 21.235
CCK-81 GDSC1; GDSC2 6.2823 8.5374 2.5822 0.5601
CL-11 GDSC1; GDSC2 6.3248 8.3393 2.6693 0.3414
HCT 15 GDSC1; GDSC2 6.3878 14.4482 0.0594 12.218
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 2.5822 3.3832 2.4971 7.8751
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC1; GDSC2 0.754 2.9417 0.6134 26.4942
JHH-1 GDSC1; GDSC2 2.2294 4.0591 1.8707 12.9556
JHH-6 GDSC1; GDSC2 2.4246 17.5782 -4.5671 36.1588
HLE GDSC1; GDSC2 2.6079 6.6681 1.022 16.656
SK-HEP-1 GDSC1; GDSC2 3.2787 10.3429 -0.2246 21.1395
Hep 3B2.1-7 GDSC1; GDSC2 3.3643 9.164 0.4362 17.5571
JHH-2 GDSC1; GDSC2 3.946 6.2356 2.3467 4.5783
SNU-387 GDSC1; GDSC2 3.9491 20.0965 -4.5486 32.376
Hep-G2/C3A GDSC1; GDSC2 4.2528 5.8847 2.708 1.8722
SNU-423 GDSC1; GDSC2 4.6922 17.9055 -2.8617 26.8141
HuH-1 GDSC1; GDSC2 4.8177 6.8378 2.5985 1.6555
SNU-449 GDSC1; GDSC2 4.9853 9.685 1.397 8.0218
JHH-7 GDSC1; GDSC2 5.3868 7.3405 2.663 0.8347
Huh-7 GDSC1; GDSC2 5.5909 7.2608 2.7762 0.3758
JHH-4 GDSC1; GDSC2 5.9473 13.2997 0.3148 11.852
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 185 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RERF-LC-KJ GDSC1; GDSC2 -11.148 0.6552 -11.8296 84.1598
NCI-H1568 GDSC1; GDSC2 -10.2404 2.8466 -11.352 79.7722
NCI-H1734 GDSC2 -8.0277 0.3788 -8.4026 81.637
NCI-H596 GDSC1; GDSC2 -6.8736 15.4065 -12.4419 62.3448
EPLC-272H GDSC1; GDSC2 -6.8051 4.528 -8.0814 71.7285
NCI-H1703 GDSC1 -6.0953 12.3356 -10.3001 65.3447
EMC-BAC-2 GDSC1; GDSC2 -5.2458 4.0878 -6.2481 68.1927
HCC366 GDSC1; GDSC2 -4.0012 4.427 -4.9969 63.1439
NCI-H2110 GDSC1; GDSC2 -3.1237 11.6524 -6.9519 55.1855
NCI-H2085 GDSC1; GDSC2 -2.5402 12.4463 -6.7242 53.0841
HCC44 GDSC1; GDSC2 -2.2098 2.0577 -2.4228 54.7161
NCI-H23 GDSC1; GDSC2 -1.6475 9.2218 -4.3658 49.9389
NCI-H196 GDSC1; GDSC2 -1.483 5.4286 -2.6172 48.8248
NCI-H1299 GDSC1; GDSC2 -0.6257 3.991 -1.1859 41.4425
NCI-H1048 GDSC1; GDSC2 -0.1169 9.4307 -2.9206 42.0401
HOP-62 GDSC1; GDSC2 0.1371 4.3614 -0.4843 34.7699
NCI-H1781 GDSC1; GDSC2 0.1509 36.3638 -15.9107 47.2757
NCI-H1688 GDSC1 0.2191 9.7513 -2.7403 45.1815
NCI-H211 GDSC1; GDSC2 0.4634 6.1967 -0.8727 34.5737
NCI-H1869 GDSC1; GDSC2 0.7235 2.4825 0.6635 26.3811
NCI-H647 GDSC1; GDSC2 0.9156 5.0771 0.0717 28.502
NCI-H1693 GDSC1; GDSC2 0.9613 8.3995 -1.3781 34
NCI-H2795 GDSC1; GDSC2 1.0234 5.5503 -0.0151 28.4318
CAL-12T GDSC1; GDSC2 1.0452 5.6024 -0.0151 28.3348
Lu-65 GDSC1; GDSC2 1.0622 9.7344 -1.9188 35.1358
CPC-N GDSC1; GDSC2 1.084 2.1477 1.0746 22.5054
NCI-H441 GDSC1; GDSC2 1.1661 11.487 -2.6719 36.5342
NCI-H82 GDSC1; GDSC2 1.1858 1.8973 1.1849 21.4411
NCI-H524 GDSC1; GDSC2 1.328 2.1457 1.3245 20.0265
NCI-H446 GDSC1; GDSC2 1.3757 3.1405 1.2447 20.2144
Lu-135 GDSC1; GDSC2 1.4857 2.6112 1.458 18.5676
SK-LU-1 GDSC1; GDSC2 1.5764 15.7036 -4.3776 38.2223
NCI-H1341 GDSC1 1.6567 32.4168 -12.6355 45.8682
DMS 79 GDSC1; GDSC2 1.6869 3.9887 1.3196 18.4078
NCI-H3255 GDSC1; GDSC2 1.7506 5.4422 0.7771 21.2373
NCI-H2342 GDSC1 1.7606 4.8017 1.0697 24.2038
NCI-H2227 GDSC1; GDSC2 1.8057 3.4997 1.6155 16.2284
Calu-6 GDSC1; GDSC2 1.8183 25.4946 -9.0411 42.1342
Lu-139 GDSC1; GDSC2 1.8522 2.9279 1.8059 14.9866
NCI-H2228 GDSC1; GDSC2 1.8681 19.5677 -6.0422 39.5371
NCI-H835 GDSC1 1.8708 6.7106 0.3059 28.2484
NCI-H2122 GDSC1; GDSC2 1.8785 8.0952 -0.3534 26.4732
NCI-H1437 GDSC1; GDSC2 1.8935 4.1056 1.4961 16.5221
LXF 289 GDSC1; GDSC2 1.8977 13.3771 -2.9369 34.6325
Lu-134-A GDSC1; GDSC2 1.9423 3.8233 1.6548 15.4071
NCI-H2030 GDSC1; GDSC2 1.9446 5.8384 0.7891 20.4088
PC-14 GDSC1; GDSC2 1.9569 8.7318 -0.5905 27.2021
EMC-BAC-1 GDSC1; GDSC2 1.9607 4.4065 1.4454 16.5374
NCI-H209 GDSC1; GDSC2 2.0575 4.7597 1.3939 16.4519
NCI-H69 GDSC1 2.127 3.5656 1.944 16.16
SBC-3 GDSC1; GDSC2 2.1568 3.1601 2.0907 12.036
NCI-H1581 GDSC1; GDSC2 2.2242 12.8975 -2.4088 32.3238
Lu-165 GDSC1; GDSC2 2.2244 3.0928 2.178 11.2538
NCI-H1694 GDSC1; GDSC2 2.2245 3.3833 2.107 11.635
HCC15 GDSC1; GDSC2 2.2445 23.2646 -7.5609 40.1474
LK-2 GDSC1; GDSC2 2.2592 3.2017 2.1926 11.0114
LB647-SCLC GDSC1; GDSC2 2.289 3.4941 2.1434 11.1443
COR-L32 GDSC1; GDSC2 2.2963 3.9893 1.9694 12.1051
NCI-H187 GDSC1 2.297 3.0597 2.2626 13.0318
IST-SL1 GDSC1; GDSC2 2.307 11.4685 -1.6253 29.7787
SBC-1 GDSC1; GDSC2 2.3101 3.649 2.1138 11.2173
NCI-H2731 GDSC1; GDSC2 2.3147 4.2799 1.8676 12.6283
COR-L279 GDSC1 2.3303 3.0716 2.2964 12.6125
COR-L88 GDSC1 2.3459 3.564 2.182 13.3003
NCI-H2196 GDSC2 2.3572 5.4278 1.3865 15.3584
COR-L321 GDSC1; GDSC2 2.3698 3.3408 2.2776 10.0414
NCI-H1876 GDSC1; GDSC2 2.3713 3.2123 2.3122 9.8478
NCI-H2347 GDSC1 2.3756 3.9115 2.0845 13.8364
NCI-H2804 GDSC1; GDSC2 2.4288 8.8495 -0.2174 23.8622
NCI-H748 GDSC2 2.4372 3.8135 2.1887 10.2481
NCI-H146 GDSC1; GDSC2 2.4483 3.4615 2.3271 9.4149
NCI-H526 GDSC1; GDSC2 2.4706 3.1724 2.429 8.7585
NCI-H3122 GDSC1; GDSC2 2.4732 7.8305 0.3264 21.0119
NCI-H345 GDSC1; GDSC2 2.5013 11.805 -1.6215 29.1299
NCI-H847 GDSC1 2.5126 3.2601 2.4547 10.4937
NCI-H1963 GDSC2 2.5458 3.7583 2.3258 9.0017
DMS 273 GDSC1; GDSC2 2.5465 3.736 2.3352 8.9445
NCI-H1092 GDSC1; GDSC2 2.5472 3.2933 2.484 8.1063
NCI-H1836 GDSC1; GDSC2 2.548 4.1512 2.1641 9.9433
COR-L303 GDSC2 2.5529 3.4692 2.4383 8.3317
NCI-H358 GDSC1; GDSC2 2.5735 6.8446 0.9037 17.4658
ChaGo-K-1 GDSC1; GDSC2 2.5866 4.1435 2.2071 9.5349
COR-L311 GDSC2 2.5934 3.545 2.4564 8.0522
NCI-H1755 GDSC1; GDSC2 2.5987 13.8877 -2.5751 31.5978
NCI-H1105 GDSC1; GDSC2 2.6002 3.511 2.4756 7.9146
NCI-H2023 GDSC1; GDSC2 2.6046 3.7932 2.3742 8.4769
NCI-H2461 GDSC1; GDSC2 2.6099 3.7035 2.4154 8.2159
NCI-H740 GDSC2 2.6137 3.7632 2.3959 8.3131
SW1271 GDSC1; GDSC2 2.615 10.9065 -1.0745 26.8372
NCI-H838 GDSC1; GDSC2 2.6316 3.7668 2.4134 8.1371
NCI-H2171 GDSC2 2.6352 3.6837 2.45 7.9102
DMS 114 GDSC1; GDSC2 2.6418 3.3725 2.5653 7.2307
NCI-H1666 GDSC1; GDSC2 2.6569 4.0201 2.3332 8.5071
HCC33 GDSC2 2.657 3.8014 2.4261 7.9589
LCLC-103H GDSC1; GDSC2 2.6853 16.9165 -4.0129 34.508
NCI-H1436 GDSC1; GDSC2 2.6931 3.5471 2.5632 7.0161
COR-L95 GDSC1 2.7086 3.8769 2.4484 9.4898
NCI-H1435 GDSC1; GDSC2 2.7243 12.6694 -1.8587 29.181
NCI-H250 GDSC2 2.732 3.8383 2.4892 7.2838
NCI-H1770 GDSC1; GDSC2 2.7477 4.0546 2.4109 7.6887
NCI-H513 GDSC1; GDSC2 2.7904 4.6135 2.1932 8.858
NCI-H1650 GDSC1; GDSC2 2.8369 12.641 -1.7478 28.4832
NCI-H2141 GDSC1; GDSC2 2.8594 3.995 2.5507 6.4186
NCI-H1975 GDSC1; GDSC2 2.8761 4.7692 2.2 8.5155
NCI-H1993 GDSC1; GDSC2 2.885 5.3073 1.9452 10.0741
NCI-H460 GDSC1; GDSC2 2.9478 3.7314 2.7584 4.8292
Lu-99A GDSC1; GDSC2 3.0044 4.3009 2.5479 5.9096
HCC78 GDSC1; GDSC2 3.0211 6.2257 1.6123 11.7125
HOP-92 GDSC1; GDSC2 3.0222 4.6442 2.397 6.79
A-427 GDSC1; GDSC2 3.0272 12.4263 -1.4781 27.0006
NCI-H650 GDSC1; GDSC2 3.0609 13.6392 -2.0558 28.7727
NCI-H661 GDSC1; GDSC2 3.1077 4.5056 2.5433 5.5904
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 3.126 5.8712 1.8805 9.7071
NCI-H2369 GDSC1; GDSC2 3.1293 5.4989 2.069 8.5098
NCI-H520 GDSC1; GDSC2 3.1633 4.4148 2.6382 4.8132
NCI-H1838 GDSC1 3.175 5.1327 2.2914 8.6742
NCI-H2869 GDSC1; GDSC2 3.1804 4.3973 2.6622 4.6079
SBC-5 GDSC1; GDSC2 3.1908 4.8116 2.4652 5.8182
NCI-H2029 GDSC1; GDSC2 3.2335 5.0651 2.3756 6.2541
NCI-H810 GDSC1; GDSC2 3.2455 4.7245 2.556 5.076
NCI-H1915 GDSC1; GDSC2 3.2523 4.4076 2.72 4.0187
NCI-H322M GDSC1; GDSC2 3.2717 5.0105 2.4354 5.7605
NCI-H2081 GDSC1; GDSC2 3.2741 4.6328 2.6262 4.5456
COR-L23 GDSC1; GDSC2 3.3243 4.783 2.5934 4.6057
IST-SL2 GDSC1; GDSC2 3.35 6.2794 1.8665 9.1263
NCI-H1623 GDSC1; GDSC2 3.3523 5.1702 2.4229 5.6043
LCLC-97TM1 GDSC1; GDSC2 3.3625 5.951 2.041 7.9903
SK-MES-1 GDSC1; GDSC2 3.3724 5.3569 2.3462 6.0327
NCI-H1792 GDSC1; GDSC2 3.4207 5.8809 2.1238 7.3022
HCC827 GDSC1; GDSC2 3.4229 8.9381 0.5975 16.5055
NCI-H1651 GDSC1; GDSC2 3.4247 8.0542 1.0409 13.969
LC-2/ad GDSC1; GDSC2 3.4558 6.9874 1.5995 10.4925
Ms-1 GDSC1; GDSC2 3.4844 6.2928 1.9697 8.0963
NCI-H1304 GDSC1 3.506 5.2094 2.5269 5.634
NCI-H720 GDSC1; GDSC2 3.5148 6.0213 2.1294 7.0064
ABC-1 GDSC1; GDSC2 3.5178 6.8906 1.6981 9.7052
LOU-NH91 GDSC1; GDSC2 3.532 5.1436 2.5797 4.123
NCI-H1944 GDSC1; GDSC2 3.5523 6.2532 2.0436 7.445
NCI-H2291 GDSC1; GDSC2 3.5655 5.4393 2.4588 4.7967
NCI-H2722 GDSC1; GDSC2 3.5945 5.3718 2.5144 4.3732
NCI-H2810 GDSC1; GDSC2 3.6024 13.1432 -1.357 24.886
BEN GDSC1; GDSC2 3.7762 9.8048 0.4509 16.2888
NCI-H2818 GDSC1; GDSC2 3.8263 6.4574 2.1521 6.061
NCI-H2373 GDSC1; GDSC2 3.9562 6.0352 2.4506 3.9226
NCI-H290 GDSC1; GDSC2 3.9992 6.8295 2.0955 5.9999
NCI-H522 GDSC1; GDSC2 4.1282 13.6399 -1.1816 22.7881
RERF-LC-MS GDSC1; GDSC2 4.1527 17.0721 -2.8737 28.1487
RERF-LC-Sq1 GDSC1; GDSC2 4.171 8.6688 1.3189 10.313
NCI-H2087 GDSC1; GDSC2 4.2029 7.4849 1.9211 6.6018
NCI-H2595 GDSC1; GDSC2 4.2137 16.5378 -2.5584 27.1294
NCI-H1563 GDSC1; GDSC2 4.2187 6.872 2.2271 4.7155
SHP-77 GDSC1; GDSC2 4.2508 10.6362 0.4072 15.2454
COR-L105 GDSC1; GDSC2 4.3137 9.2029 1.1615 10.8896
VMRC-LCD GDSC1; GDSC2 4.3193 6.416 2.5059 2.8855
IA-LM GDSC1; GDSC2 4.3483 7.7384 1.8994 6.4112
PaCa-3 GDSC1 4.3916 9.5842 1.0313 13.9114
NCI-H2444 GDSC1; GDSC2 4.4048 5.8109 2.822 1.0856
NCI-H510A GDSC2 4.4211 7.5159 2.0551 5.3263
SW1573 GDSC1; GDSC2 4.4389 6.7017 2.4473 3.0091
NCI-H841 GDSC1; GDSC2 4.5208 9.9687 0.937 11.6772
NCI-H2170 GDSC1; GDSC2 4.5264 9.5542 1.1437 10.4855
NCI-H2172 GDSC1; GDSC2 4.585 11.8352 0.0666 16.1333
EKVX GDSC1; GDSC2 4.6123 8.1424 1.8837 5.9523
NCI-H1355 GDSC1; GDSC2 4.6139 15.8236 -1.8875 24.0669
KNS-62 GDSC1; GDSC2 4.6326 12.3612 -0.1573 17.097
NCI-H226 GDSC1; GDSC2 4.6386 6.0018 2.8558 0.7043
UMC-11 GDSC1; GDSC2 4.6487 6.3102 2.7351 1.2107
EBC-1 GDSC1; GDSC2 4.7011 14.6624 -1.2439 21.5576
NCI-H1648 GDSC1 4.7829 16.8023 -2.2428 27.7081
NCI-H2009 GDSC1 5.0227 13.4343 -0.3964 20.057
NCI-H1573 GDSC1 5.173 7.0178 2.6949 1.0977
NCI-H2135 GDSC1; GDSC2 5.2823 6.7939 2.8255 0.3883
DMS 53 GDSC1; GDSC2 5.3616 7.4863 2.5947 1.1111
NCI-H1793 GDSC1; GDSC2 5.4257 11.3272 0.9076 9.8432
NCI-H2066 GDSC1 5.4382 7.2074 2.7352 0.7017
NCI-H292 GDSC1; GDSC2 5.4758 17.2228 -1.9254 22.1711
NCI-H727 GDSC1; GDSC2 5.5276 7.685 2.5908 0.9906
NCI-H2405 GDSC1; GDSC2 5.5455 8.3852 2.3153 2.1344
A-549 GDSC1; GDSC2 5.7396 16.0881 -1.1757 18.8775
Calu-3 GDSC1; GDSC2 5.7983 13.0959 0.3128 12.1634
NCI-H2591 GDSC1; GDSC2 5.8639 8.3063 2.4963 1.0793
NCI-H2803 GDSC1; GDSC2 5.9405 7.622 2.7791 0.2468
NCI-H1155 GDSC1; GDSC2 5.9876 14.0943 -0.0374 13.4659
LC-1/sq GDSC1; GDSC2 6.1071 14.0947 0.0425 12.8478
COLO 668 GDSC1; GDSC2 6.2091 7.9808 2.7518 0.2224
⏷ Show the Full List of 185 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 2.1873 3.6685 1.9743 12.5389
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-140 GDSC1; GDSC2 -2.9912 26.4495 -13.8483 52.4525
KYSE-270 GDSC1; GDSC2 -1.4056 2.3464 -1.6075 47.7047
OE33 GDSC1; GDSC2 -0.0529 12.9282 -4.5191 43.6067
OE21 GDSC1; GDSC2 1.0337 9.2291 -1.7032 34.6617
COLO 680N GDSC1; GDSC2 1.8949 11.6111 -2.0647 32.4843
TE-4 GDSC1; GDSC2 2.0062 4.2477 1.5587 15.6909
KYSE-510 GDSC1; GDSC2 2.329 12.5473 -2.1423 31.266
KYSE-410 GDSC1; GDSC2 2.4472 3.6005 2.279 9.6893
KYSE-450 GDSC1; GDSC2 2.6757 3.7226 2.4777 7.5809
KYSE-150 GDSC1 2.6785 3.4403 2.5842 8.6726
OE19 GDSC1; GDSC2 2.6983 3.3842 2.6234 6.6566
EC-GI-10 GDSC1; GDSC2 2.7874 6.7382 1.1501 15.2933
TE-1 GDSC1; GDSC2 3.16 9.5483 0.0728 20.0629
TE-5 GDSC1; GDSC2 3.2334 5.6176 2.0995 8.0002
T.T GDSC1 3.4865 7.3804 1.4282 14.1299
TE-15 GDSC1; GDSC2 3.4928 6.4206 1.9126 8.4321
TE-9 GDSC1; GDSC2 3.7757 5.7009 2.4862 4.1091
TE-8 GDSC1; GDSC2 4.0611 6.0768 2.5011 3.4
TE-6 GDSC1; GDSC2 4.3077 13.3771 -0.9096 21.2401
TE-10 GDSC1; GDSC2 4.3134 8.8528 1.3329 9.8843
TE-11 GDSC1; GDSC2 5.2683 10.5163 1.1888 8.6216
KYSE-70 GDSC1; GDSC2 6.4456 15.8918 -0.589 15.0102
KYSE-180 GDSC1; GDSC2 7.0952 23.5291 -3.8357 24.3596
KYSE-520 GDSC1; GDSC2 7.4242 18.4726 -1.168 15.4935
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-OV-3 GDSC1; GDSC2 -9.4636 19.1077 -16.727 64.4064
JHOS-4 GDSC1; GDSC2 -6.31 10.4293 -9.7215 64.3366
Caov-3 GDSC2 -4.664 1.7477 -5.0196 69.9581
JHOS-2 GDSC1; GDSC2 -4.4351 -1.3036 -4.4474 75.1499
TOV-21G GDSC1; GDSC2 -4.2884 3.7556 -5.1058 65.1822
OVCAR-4 GDSC1; GDSC2 -3.0034 7.977 -5.2387 56.1822
EFO-21 GDSC1; GDSC2 -2.1709 3.7286 -2.7884 53.7313
OVCAR-8 GDSC1; GDSC2 -1.0837 3.9934 -1.6849 45.4212
OC 314 GDSC1 1.4002 12.4213 -2.9141 40.2768
Kuramochi GDSC1; GDSC2 1.981 14.1931 -3.2679 35.0739
A2780 GDSC1; GDSC2 1.9991 3.7459 1.7437 14.6587
RMG-I GDSC1 2.0335 3.6603 1.8108 17.6001
Caov-4 GDSC1 2.4912 22.8451 -7.1403 41.6549
IGROV-1 GDSC2 2.6026 4.0023 2.2849 9.0097
OVK18 GDSC1; GDSC2 2.7429 8.8142 0.0795 21.3639
EFO-27 GDSC1; GDSC2 2.7527 4.6811 2.1246 9.4161
OVCAR-5 GDSC1; GDSC2 3.0343 3.9089 2.7642 4.4669
ES-2 GDSC1; GDSC2 3.0416 3.9876 2.7341 4.626
OV-90 GDSC1; GDSC2 3.0627 10.0442 -0.2576 21.9598
DOV13 GDSC1; GDSC2 3.0954 4.0727 2.7443 4.3738
TOV-112D GDSC1; GDSC2 3.1404 5.1242 2.2654 7.2366
OVISE GDSC1; GDSC2 3.193 5.1667 2.29 6.9179
TYK-nu GDSC1; GDSC2 3.5645 7.3282 1.5172 10.6963
OAW42 GDSC1; GDSC2 3.9132 7.6468 1.6303 9.0755
OVKATE GDSC1 4.2279 8.0829 1.6477 10.126
OVTOKO GDSC1; GDSC2 4.2575 9.1801 1.1312 11.2034
FU-OV-1 GDSC1 4.5822 8.7607 1.5677 9.7003
OV56 GDSC1; GDSC2 4.6621 10.1092 0.97 11.1587
OVCAR-3 GDSC1; GDSC2 4.6968 11.0993 0.5111 13.5852
OAW28 GDSC1; GDSC2 5.6076 14.103 -0.303 15.4975
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 03.27 GDSC1 -6.4839 -0.6712 -6.6108 87.2778
BxPC-3 GDSC1; GDSC2 -2.7655 15.3171 -8.2807 53.2531
CFPAC-1 GDSC1; GDSC2 1.5187 10.0206 -1.6277 32.561
MIA PaCa-2 GDSC1; GDSC2 1.5289 7.4343 -0.3693 27.9057
DAN-G GDSC1; GDSC2 2.2116 10.8628 -1.4096 29.3867
QGP-1 GDSC1; GDSC2 2.3884 11.3651 -1.5019 29.1038
PSN1 GDSC1; GDSC2 2.5196 3.7278 2.3096 9.2052
KP-4 GDSC1; GDSC2 2.7757 12.378 -1.669 28.4161
HPAF-II GDSC1; GDSC2 2.9208 6.3124 1.4805 12.8483
PL4 GDSC1; GDSC2 3.3515 16.7564 -3.3707 31.4161
Panc 10.05 GDSC1; GDSC2 3.5672 13.65 -1.6392 25.9799
HuP-T4 GDSC1; GDSC2 3.5746 11.4378 -0.5274 21.6381
SU.86.86 GDSC1; GDSC2 3.6022 9.8749 0.276 17.7048
Panc 02.03 GDSC1; GDSC2 3.6044 7.1865 1.6197 9.9534
MZ-PC-1 GDSC1; GDSC2 3.6416 8.2058 1.141 12.7596
PaTu 8902 GDSC1; GDSC2 3.6895 5.1213 2.7071 2.9454
HPAC GDSC1; GDSC2 3.735 6.1112 2.2548 5.6456
YAPC GDSC1; GDSC2 3.985 11.1736 -0.0659 18.3473
Capan-2 GDSC1; GDSC2 3.9993 6.2921 2.3564 4.4017
KP-1N GDSC1; GDSC2 4.0189 11.2843 -0.0944 18.3927
PaTu 8988t GDSC1; GDSC2 4.1992 7.2043 2.0543 5.8006
KP-2 GDSC1; GDSC2 4.2715 12.1707 -0.3381 18.8633
SW1990 GDSC1 4.4285 16.1668 -2.2032 28.5719
Panc 08.13 GDSC1; GDSC2 4.5418 9.688 1.0894 10.7615
SUIT-2 GDSC1; GDSC2 4.6003 6.4862 2.6353 1.7515
Capan-1 GDSC1; GDSC2 4.6447 15.8827 -1.893 24.0095
HuP-T3 GDSC1; GDSC2 4.789 9.0225 1.582 7.3587
Hs 766T GDSC1 4.8377 8.1127 2.041 5.7209
KP-3 GDSC1; GDSC2 5.7751 8.2487 2.4797 1.2107
AsPC-1 GDSC1; GDSC2 6.7563 21.0231 -2.8554 22.3955
Panc 04.03 GDSC1 7.0769 16.4641 -0.4454 15.2423
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 GDSC1 3.2403 5.0995 2.3642 7.8533
NCI-H28 GDSC1; GDSC2 3.3555 4.6926 2.6644 4.0664
MSTO-211H GDSC1; GDSC2 3.4448 6.0522 2.0578 7.6516
MPP 89 GDSC1; GDSC2 4.5471 6.4198 2.6355 1.8225
IST-Mes1 GDSC1; GDSC2 5.2721 7.143 2.6897 0.824
NCI-H2052 GDSC2 6.3036 8.2603 2.6891 0.3087
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1; GDSC2 2.6145 5.012 1.8335 11.7022
NCI-H660 GDSC2 2.7255 3.7298 2.5275 7.0856
VCaP GDSC1; GDSC2 2.9416 5.5234 1.8901 10.2318
22Rv1 GDSC1; GDSC2 3.0072 4.2629 2.569 5.7688
DU145 GDSC1; GDSC2 4.0099 7.2407 1.9021 7.1657
PC-3 GDSC1; GDSC2 4.1212 9.4378 0.9019 12.8679
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 2.7075 11.4715 -1.2756 27.2801
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A101D GDSC1; GDSC2 -7.747 0.7224 -8.1604 80.4617
WM1552C GDSC1; GDSC2 -6.6111 -1.0832 -6.7063 82.8214
A-388 GDSC1; GDSC2 -5.8059 24.7117 -15.6851 57.3297
SK-MEL-30 GDSC1; GDSC2 -2.8856 10.4761 -6.1858 54.7583
SK-MEL-5 GDSC1; GDSC2 -1.1043 4.7469 -1.961 45.9144
RPMI-7951 GDSC1; GDSC2 -0.0955 21.5843 -8.7932 46.1244
IST-MEL1 GDSC1 -0.0264 2.9731 -0.2432 42.7065
VMRC-MELG GDSC1; GDSC2 0.4076 9.3205 -2.3531 38.8161
A2058 GDSC1; GDSC2 0.469 25.4331 -10.1928 45.4006
Hs 940.T GDSC1; GDSC2 0.8504 16.6716 -5.51 41.6886
SH-4 GDSC1; GDSC2 1.1801 2.8636 1.0918 21.9486
LOX-IMVI GDSC1; GDSC2 1.4508 2.3571 1.4421 18.8211
SK-MEL-2 GDSC1; GDSC2 1.5119 3.4539 1.309 19.2395
Mel Ho GDSC1; GDSC2 1.6052 3.2235 1.4744 17.913
WM278 GDSC1; GDSC2 1.6776 10.8523 -1.8882 32.7468
WM793 GDSC1; GDSC2 1.7769 3.233 1.6593 16.1207
SK-MEL-3 GDSC1; GDSC2 2.1699 3.235 2.0873 11.9929
COLO 800 GDSC1; GDSC2 2.1999 10.0261 -1.0057 27.9797
HMV-II GDSC1; GDSC2 2.3422 3.5717 2.1754 10.7304
Mel JuSo GDSC1; GDSC2 2.3606 3.1552 2.3131 9.893
COLO 829 GDSC1; GDSC2 2.4999 3.7793 2.2687 9.5232
IPC-298 GDSC1; GDSC2 2.5301 3.5916 2.3716 8.8061
G-361 GDSC1; GDSC2 2.564 3.5225 2.4325 8.3149
WM115 GDSC1; GDSC2 2.6237 3.6537 2.4493 7.9628
MeWo GDSC1 2.6356 4.3731 2.1536 12.0427
MZ-MEL-2 GDSC1; GDSC2 2.6388 3.6395 2.4708 7.7754
HT-144 GDSC1; GDSC2 2.6443 3.384 2.5645 7.2243
COLO 783 GDSC1; GDSC2 2.6671 3.9341 2.381 8.1832
G-mel GDSC1; GDSC2 2.7006 4.3099 2.2476 8.854
UACC-257 GDSC1; GDSC2 2.7109 3.7806 2.4912 7.3574
COLO 679 GDSC1; GDSC2 2.7603 3.8682 2.5058 7.0725
GAK GDSC1; GDSC2 2.8039 3.9787 2.5019 6.9248
M14 GDSC1; GDSC2 2.8268 3.8291 2.5913 6.3012
SK-MEL-28 GDSC1; GDSC2 2.8676 3.4105 2.7994 4.9251
IGR-37 GDSC1; GDSC2 2.8822 3.9845 2.5784 6.1646
MZ-MEL-7 GDSC1; GDSC2 3.0327 4.541 2.4573 6.3778
LB373-MEL-D GDSC1; GDSC2 3.0334 5.3539 2.0565 8.8915
A-375 GDSC1; GDSC2 3.0763 6.0691 1.7386 10.752
CP50-MEL-B GDSC1; GDSC2 3.1688 4.4955 2.6031 5.017
WT2-iPS GDSC1; GDSC2 3.1771 4.1832 2.7653 3.9695
UACC-62 GDSC1; GDSC2 3.183 4.4388 2.6439 4.715
CHL-1 GDSC1; GDSC2 3.2242 5.4659 2.1675 7.5977
Hs 938.T GDSC1; GDSC2 3.2245 7.6549 1.0737 14.3696
RVH-421 GDSC1; GDSC2 3.3719 5.302 2.3733 5.8626
SK-MEL-1 GDSC1 3.433 9.3353 0.4073 20.9866
IGR-1 GDSC1; GDSC2 3.4979 8.6742 0.791 15.2028
LB2518-MEL GDSC1; GDSC2 3.5142 9.5784 0.3524 17.5601
451Lu GDSC1; GDSC2 3.5463 5.189 2.5681 4.159
MMAc-SF GDSC1; GDSC2 3.5579 5.0302 2.6556 3.5806
SK-MEL-31 GDSC1; GDSC2 3.5766 8.9799 0.7023 15.4769
WM35 GDSC1; GDSC2 3.6306 14.9957 -2.2597 27.7788
SK-MEL-24 GDSC1; GDSC2 4.5484 12.2859 -0.1835 17.4315
COLO 792 GDSC1; GDSC2 4.5528 13.8204 -0.9401 20.7341
A-431 GDSC1; GDSC2 5.0221 19.5198 -3.4074 27.4783
CP66-MEL GDSC1; GDSC2 5.1991 6.4341 2.9225 0.1964
DJM-1 GDSC1; GDSC2 5.6089 17.9152 -2.1675 22.6702
EquiPSC Line K2 GDSC1; GDSC2 4.6049 6.6621 2.561 2.1266
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 2.5381 4.1329 2.1619 9.9951
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-204 GDSC1; GDSC2 -9.3553 -0.7327 -9.654 85.533
KYM-1 GDSC1; GDSC2 -8.5294 -5.8342 -8.5296 97.605
GCT GDSC1; GDSC2 -8.2144 0.2246 -8.5777 82.2337
SW872 GDSC1; GDSC2 -6.0055 -0.5451 -6.1193 79.8879
STS-0421 GDSC1; GDSC2 -3.3405 4.8824 -4.4279 59.7058
RKN GDSC1; GDSC2 -0.7025 7.5494 -2.6619 44.4379
SW684 GDSC1; GDSC2 -0.3919 46.8629 -21.616 48.5323
G-402 GDSC1; GDSC2 -0.3447 7.5365 -2.2891 42.1216
Rh41 GDSC1; GDSC2 0.4309 1.8023 0.4189 29.0721
EW-8 GDSC1; GDSC2 1.7129 9.2371 -1.0643 29.9615
Rh18 GDSC1 1.8226 3.1389 1.7317 19.3312
Rh30 GDSC1; GDSC2 1.8926 3.9065 1.5708 16.0982
MES-SA GDSC1; GDSC2 2.0341 2.8595 2.0105 13.0439
G-401 GDSC1; GDSC2 2.1841 10.4132 -1.2115 28.7914
SW982 GDSC1; GDSC2 2.6361 6.6861 1.0389 16.4608
HT-1080 GDSC1; GDSC2 2.6375 4.9806 1.8706 11.3917
TE 441.T GDSC2 2.7629 4.0675 2.4206 7.5717
SK-LMS-1 GDSC1; GDSC2 2.799 12.7371 -1.8282 28.8556
RD GDSC1; GDSC2 3.1248 4.1953 2.7118 4.477
VA-ES-BJ GDSC1; GDSC2 3.3252 9.7673 0.1019 19.4117
MFH-ino GDSC1 3.5536 11.7376 -0.6945 26.0006
Hs 633.T GDSC1 5.5855 7.2323 2.7844 0.4463
SK-UT-1 GDSC1; GDSC2 5.7341 14.8107 -0.5575 16.3517
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TMK-1 GDSC1; GDSC2 -8.7261 4.7519 -10.243 74.9818
SK-GT-2 GDSC1; GDSC2 -5.6381 3.5411 -6.5172 70.2383
SNU-5 GDSC1; GDSC2 -3.431 2.3358 -3.8038 62.913
Hs 746.T GDSC1; GDSC2 -3.1552 36.6837 -19.0229 52.0468
AGS GDSC1; GDSC2 -1.5361 15.7227 -7.2794 49.6166
OCUM-1 GDSC1; GDSC2 0.2109 16.9495 -6.2312 44.0952
ECC10 GDSC1; GDSC2 1.3927 2.3193 1.384 19.4039
Fu97 GDSC1 1.7188 3.086 1.6307 20.6091
RERF-GC-1B GDSC1; GDSC2 1.9832 7.7527 -0.0886 24.8607
SCH GDSC1; GDSC2 2.0536 3.5514 1.8689 13.7171
SNU-16 GDSC1 2.0809 2.8932 2.056 15.6712
HGC-27 GDSC1; GDSC2 2.1108 2.9154 2.0849 12.2862
MKN1 GDSC1; GDSC2 2.1765 3.5218 2.0121 12.375
MKN28 GDSC1; GDSC2 2.2165 3.5597 2.0432 12.024
NCI-N87 GDSC1; GDSC2 2.3026 4.1243 1.9208 12.3631
IM95 GDSC1; GDSC2 2.3113 3.8718 2.0319 11.6809
NUGC-4 GDSC1; GDSC2 2.479 3.4919 2.3506 9.1478
ECC12 GDSC2 2.5129 4.3605 2.0356 10.8486
NUGC-3 GDSC1; GDSC2 2.671 4.1618 2.285 8.7409
MKN7 GDSC1; GDSC2 2.9562 4.8011 2.2591 7.8737
RF-48 GDSC1; GDSC2 3.0039 6.1414 1.6391 11.5999
MKN45 GDSC1; GDSC2 3.3267 4.6951 2.6393 4.3082
SNU-1 GDSC1; GDSC2 3.3781 5.9516 2.0536 7.8664
23132/87 GDSC1; GDSC2 3.5715 16.0634 -2.8421 29.5526
KATO III GDSC1; GDSC2 3.6323 6.0501 2.2071 6.2056
HSC-39 GDSC1 3.7455 5.8768 2.378 6.0417
GCIY GDSC2 4.4381 9.1093 1.2975 9.7979
TGBC11TKB GDSC1 5.0828 7.4325 2.4823 2.354
SNG-M GDSC1; GDSC2 -3.9818 -2.8306 -3.9818 73.2614
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC1; GDSC2 1.6011 4.2719 1.12 19.9059
B-CPAP GDSC1; GDSC2 1.7228 11.3674 -2.1005 33.1768
CGTH-W-1 GDSC1 1.8155 3.0917 1.7346 19.3533
8505C GDSC1; GDSC2 2.2828 7.1503 0.4852 20.8371
FTC-133 GDSC1; GDSC2 2.3122 21.7178 -6.7305 39.2114
IHH-4 GDSC1; GDSC2 2.4671 13.7028 -2.597 32.0517
KMH-2 GDSC1; GDSC2 2.6315 4.6079 2.0408 10.3699
TT GDSC1 3.4799 6.2955 1.9646 10.1184
8305C GDSC1; GDSC2 3.8037 7.8167 1.4624 10.3854
WRO GDSC1; GDSC2 3.8136 5.6465 2.5395 3.6938
HTC-C3 GDSC1; GDSC2 3.9142 11.7557 -0.4121 20.1627
CAL-62 GDSC1; GDSC2 4.4171 6.0709 2.7171 1.5844
BHT-101 GDSC1; GDSC2 4.7851 11.352 0.4514 13.6887
ASH-3 GDSC1; GDSC2 4.8775 8.5673 1.8546 5.6042
TT2609-C02 GDSC1; GDSC2 5.5313 11.6603 0.819 10.1034
ML-1 [Human leukemia] GDSC1; GDSC2 5.5867 7.4301 2.7127 0.5478
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 22 GDSC1; GDSC2 -7.6201 13.2788 -12.2849 64.8632
HSC-3 GDSC1; GDSC2 -7.3612 -4.0014 -7.364 92.5618
KOSC-2 GDSC1; GDSC2 -6.012 2.8841 -6.7483 72.4097
BB30-HNC GDSC1; GDSC2 -3.673 5.77 -5.0969 60.412
SKN-3 GDSC1; GDSC2 -2.1845 4.1522 -2.9331 53.6657
Detroit 562 GDSC1; GDSC2 1.2275 9.0798 -1.4461 33.1249
HSC-2 GDSC1; GDSC2 1.3992 6.1784 0.0892 26.3087
HO-1-N-1 GDSC1; GDSC2 1.4277 5.8057 0.2867 25.1975
JHU-029 GDSC1; GDSC2 1.4624 5.373 0.5143 23.8569
KON GDSC1; GDSC2 2.013 3.5219 1.8342 14.0906
PCI-04B GDSC1; GDSC2 2.1727 7.0573 0.4274 21.5473
JHU-022 GDSC1; GDSC2 2.1752 12.6909 -2.3495 32.325
DOK GDSC1; GDSC2 2.1865 14.3687 -3.1741 34.252
PCI-15A GDSC1; GDSC2 2.196 3.2092 2.1221 11.6844
SAT [Human HNSCC] GDSC1; GDSC2 2.2891 8.1052 0.0231 23.2023
SCC-9 GDSC1; GDSC2 2.3607 12.3017 -1.9921 30.7321
PCI-06A GDSC1; GDSC2 2.7401 4.1118 2.3775 7.9184
OSC-19 GDSC1; GDSC2 2.7965 4.5728 2.2185 8.6803
NCI-H3118 GDSC1; GDSC2 2.8292 3.9602 2.5359 6.623
FaDu GDSC1; GDSC2 2.8972 9.2814 -0.0188 21.3463
PCI-38 GDSC1 2.8975 4.1054 2.5377 7.9156
SCC-25 GDSC1; GDSC2 3.1045 6.7019 1.4475 12.4729
BB49-HNC GDSC1; GDSC2 3.1643 5.323 2.1872 7.6562
SAS GDSC1; GDSC2 3.1966 5.2845 2.2344 7.2588
SCC-15 GDSC1; GDSC2 3.3306 6.4347 1.7728 9.771
SCC-4 GDSC1; GDSC2 3.5243 9.7626 0.2686 17.9691
Ca9-22 GDSC1; GDSC2 3.5246 5.317 2.4878 4.7205
HSC-4 GDSC1; GDSC2 3.7259 15.1872 -2.2775 27.5748
JHU-011 GDSC1; GDSC2 3.7322 18.1578 -3.7569 31.305
PE/CA-PJ15 GDSC1; GDSC2 3.778 5.5688 2.5522 3.6968
BHY GDSC1; GDSC2 3.781 11.3044 -0.2934 19.9917
BICR 78 GDSC1; GDSC2 4.0231 10.9046 0.0979 17.4371
OSC-20 GDSC1; GDSC2 4.0467 11.901 -0.3796 19.6527
PCI-30 GDSC1 4.1701 6.5081 2.3681 4.9448
BICR 10 GDSC1; GDSC2 4.1984 6.3632 2.455 3.4026
UPCI-SCC-090 GDSC1; GDSC2 4.2132 13.335 -0.9626 21.7026
LB771-HNC GDSC1; GDSC2 4.2334 7.7387 1.8194 7.1502
HO-1-u-1 GDSC1 4.4685 7.3544 2.1624 5.7153
CAL-33 GDSC1; GDSC2 4.8594 9.7931 1.2607 9.066
BICR 31 GDSC2 4.911 10.4164 0.9958 10.45
CAL-27 GDSC1; GDSC2 5.1515 17.6412 -2.376 24.3474
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
647V GDSC1; GDSC2 -4.8147 -0.9714 -4.8478 76.5304
CAL-29 GDSC1; GDSC2 0.5228 10.1904 -2.6541 38.937
HT-1376 GDSC1 1.151 9.6432 -1.7904 39.2778
BFTC-905 GDSC2 1.2628 4.3608 0.7251 23.5656
RT-112 GDSC1; GDSC2 2.3292 3.1974 2.2699 10.2708
KU-19-19 GDSC1; GDSC2 2.6719 16.0486 -3.5909 33.7212
SW780 GDSC1; GDSC2 2.7272 11.9248 -1.4847 27.9514
HT-1197 GDSC1; GDSC2 2.794 4.4744 2.2628 8.4168
UM-UC-3 GDSC1 2.952 10.5538 -0.6068 27.8292
SW1710 GDSC1; GDSC2 3.2655 4.4782 2.6961 4.1297
TCCSUP GDSC1; GDSC2 3.3194 5.799 2.0813 7.861
639V GDSC1; GDSC2 3.4418 10.6689 -0.2521 20.7796
5637 GDSC1; GDSC2 3.6601 8.9343 0.7923 14.7324
T24 GDSC1; GDSC2 4.6635 6.5794 2.6286 1.702
J82 GDSC1; GDSC2 5.435 15.1169 -0.9206 18.5425
RT-4 GDSC1; GDSC2 6.2924 8.2064 2.7038 0.2842
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB831-BLC GDSC1; GDSC2 -0.7547 8.1066 -2.9602 45.0192
SiSo GDSC1; GDSC2 -0.5589 2.6736 -0.7555 39.7298
PA-1 GDSC2 -0.1074 3.7238 -0.5376 36.2977
DoTc2 4510 GDSC1; GDSC2 0.2205 5.718 -0.9224 35.9407
NT2-D1 GDSC1 0.7977 2.7952 0.691 32.2119
C-4-I GDSC1; GDSC2 1.1295 9.1793 -1.5875 33.9443
HT-3 GDSC1; GDSC2 1.2751 7.4382 -0.6183 29.9889
JAR GDSC1; GDSC2 1.3435 3.288 1.172 20.7544
NEC8 GDSC1; GDSC2 1.4222 2.5446 1.398 19.1864
JEG-3 GDSC1; GDSC2 1.8971 9.2245 -0.8872 28.6138
Ca Ski GDSC1; GDSC2 1.9122 3.5976 1.7002 15.2837
MS751 GDSC1; GDSC2 2.3107 3.1995 2.2492 10.4683
SKN GDSC1; GDSC2 2.5247 4.1102 2.1579 10.0721
TC-YIK GDSC1; GDSC2 2.549 3.5053 2.4221 8.4396
OVMIU GDSC1; GDSC2 2.6016 3.7509 2.3879 8.4096
C-33 A GDSC1; GDSC2 2.6037 3.7428 2.3933 8.3694
JHOS-3 GDSC1; GDSC2 2.7612 5.358 1.8057 11.3607
UWB1.289 GDSC1; GDSC2 2.9076 14.9219 -2.8268 31.3334
OVCA433 GDSC1; GDSC2 3.1201 4.3398 2.6364 4.9655
DSH1 GDSC1; GDSC2 3.1933 7.2675 1.2409 13.4623
HEY GDSC1; GDSC2 3.2092 4.4944 2.6393 4.6618
PEO1 GDSC1; GDSC2 3.3935 5.1426 2.4706 5.1858
SiHa GDSC1; GDSC2 3.3963 5.6307 2.2289 6.7065
CAL-39 GDSC1; GDSC2 3.7788 10.5814 0.0656 18.2728
SW954 GDSC1; GDSC2 3.8676 11.024 -0.0843 18.7601
BPH-1 GDSC1; GDSC2 4.3654 18.8713 -3.6012 29.4391
SW756 GDSC1; GDSC2 4.4636 6.4519 2.5748 2.2644
SKG-IIIa GDSC1; GDSC2 4.5251 13.0314 -0.5702 19.2468
ME-180 GDSC1; GDSC2 4.5393 8.9658 1.4389 8.7355
OVCA420 GDSC1; GDSC2 4.6024 6.3282 2.7041 1.41
PWR-1E GDSC1; GDSC2 4.7168 12.3387 -0.0834 16.5366
ACC-OV7 GDSC1; GDSC2 4.7478 18.8206 -3.2735 27.7632
HEC-1 GDSC1; GDSC2 4.8242 7.0404 2.515 2.0583
OV17R GDSC1; GDSC2 4.9734 8.9442 1.7391 6.0852
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 5.0098 7.4548 2.4348 2.2149
SW962 GDSC1; GDSC2 5.2188 7.3233 2.5941 1.2426
KGN GDSC1 6.2402 8.2174 2.6808 0.4307
HeLa GDSC1; GDSC2 6.9083 15.4783 -0.0907 11.9399
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug

References

1 Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.