Details of the Drug

General Information of Drug (ID: DMPMGLO)

• Drug Name: 1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one
• Synonyms: PHOP; 288862-83-9; CHEMBL175854; 1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one; 1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one; SCHEMBL3964367; CTK8E9849; LEI-104; DTXSID10435440; MolPort-009-018-760; HMS3649E22; ZINC13611906; BDBM50161518; ACM288862839; RT-015038; SR-01000946606; J-017316; SR-01000946606-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 294.3
  Logarithm of the Partition Coefficient (xlogp); 4.4
  Rotatable Bond Count (rotbonds); 7
  Hydrogen Bond Donor Count (hbonddonor); 0
  Hydrogen Bond Acceptor Count (hbondacc); 4
• Chemical Identifiers:
  Formula: C18H18N2O2
  IUPAC Name: 1-([1,3]oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one
  Canonical SMILES: C1=CC=C(C=C1)CCCCCC(=O)C2=NC3=C(O2)C=CC=N3
  InChI: InChI=1S/C18H18N2O2/c21-15(18-20-17-16(22-18)12-7-13-19-17)11-6-2-5-10-14-8-3-1-4-9-14/h1,3-4,7-9,12-13H,2,5-6,10-11H2
  InChIKey: VPZHQLPAKFVGKX-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 10085812
  ChEBI ID: CHEMBL175854
  CAS Number: 288862-83-9
  TTD ID: D0TN0A
• Drug-Molecule Activity Atlas (DMA)NEW: Click to Jump to the Detailed DMA Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fatty acid amide hydrolase (FAAH)	TTDP1UC	NOUNIPROTAC	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Fatty acid amide hydrolase (FAAH)	DTT	NO-GeName	2.65E-01	0.02	0.1

References

• [1] The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem. 2005 Aug 11;48(16):5059-87.