Details of the Drug

General Information of Drug (ID: DMPSNSC)

Drug Name

XTMAB-16

Indication

Disease Entry	ICD 11	Status	REF
Sarcoidosis	4B20.5	Phase 1/2	[1]

Drug Type

Antibody

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tumor necrosis factor (TNF)	TTF8CQI	TNFA_HUMAN	Not Available	[2]

Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Sarcoidosis

ICD Disease Classification

4B20.5

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tumor necrosis factor (TNF)	DTT	TNF	8.51E-01	0.05	0.27

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT05890729) A Seamless, Phase 1b/2 Multiple Ascending Dose/Proof of Concept Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis With or Without Extrapulmonary Manifestations. U.S.National Institutes of Health.
2	Clinical pipeline report, company report or official report of Xentria