Details of the Drug | DrugMAP

General Information of Drug (ID: DMQ4523)

Drug Name

HU6

Synonyms

HU6

Indication

Disease Entry	ICD 11	Status	REF
Heart failure with preserved ejection fraction	BD11.0	Phase 2	[1]
Non-alcoholic steatohepatitis	DB92.1	Phase 2	[2]
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Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C14H16BrN3O
Canonical SMILES: C1CC(C(C=C1)CNC2=CC(=CC3=C2C=NN3)Br)O
InChI: InChI=1S/C14H16BrN3O/c15-10-5-12(11-8-17-18-13(11)6-10)16-7-9-3-1-2-4-14(9)19/h1,3,5-6,8-9,14,16,19H,2,4,7H2,(H,17,18)/t9-,14+/m0/s1
InChIKey: KUCFPVMNWYCZRO-LKFCYVNXSA-N

Cross-matching ID

PubChem CID: 156009087
TTD ID: DY0OR1

Repurposed Drugs (RPD)

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References

1	ClinicalTrials.gov (NCT05284617) Exploratory Phase 2A, Double-blind, Placebo-Controlled, Dose Escalation Study to Determine the Safety, Tolerability, PD, and PK of HU6 for the Treatment of Subjects With Obese Heart Failure With Preserved Ejection Fraction (HFpEF). U.S.National Institutes of Health.
2	ClinicalTrials.gov (NCT04874233) A 61-day Randomized, Double Blind, Placebo-controlled Trial to Assess the Safety and Efficacy of Three Doses of HU6 in Subjects With Elevated Liver Fat and High Body Mass Index (28 to 45 kg/m2). U.S.National Institutes of Health.