Details of the Drug

General Information of Drug (ID: DMQ95EB)

Drug Name
AS-601245
Synonyms
JNK Inhibitor V; SAPK Inhibitor V; 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile; GTPL5997; SCHEMBL12242792; MolPort-044-724-552; HMS3229I20; CCG-206858; RT-013405; J-019673
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 372.4
Logarithm of the Partition Coefficient (xlogp) 3.3
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C20H16N6S
IUPAC Name
2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile
Canonical SMILES
C1=CC=C2C(=C1)N=C(S2)C(C#N)C3=NC(=NC=C3)NCCC4=CN=CC=C4
InChI
InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26)
InChIKey
RCYPVQCPYKNSTG-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
10109823
ChEBI ID
CHEBI:91345
CAS Number
345987-15-7
TTD ID
D04QCF

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glycogen synthase kinase-3 beta (GSK-3B) TTRSMW9 GSK3B_HUMAN Inhibitor [2]
JNK2 messenger RNA (JNK2 mRNA) TT3IVG2 MK09_HUMAN Inhibitor [2]
Stress-activated protein kinase JNK1 (JNK1) TT0K6EO MK08_HUMAN Inhibitor [2]
Stress-activated protein kinase JNK3 (JNK3) TT056SO MK10_HUMAN Inhibitor [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glycogen synthase kinase-3 beta (GSK-3B) DTT GSK3B 1.26E-01 -0.23 -0.77
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 2.4534 6.2012 0.9238 18.1992
HuO-3N1 GDSC1 -0.4015 11.7561 -4.458 47.4101
MHH-ES-1 GDSC1 0.034 14.4637 -5.3588 46.1883
G-292 clone A141B1 GDSC1 0.9154 2.8904 0.7539 27.0965
ES7 GDSC1 1.162 3.6982 0.768 25.5775
NY GDSC1 1.5875 4.0968 1.0647 21.2498
ES6 GDSC1 1.6734 4.1346 1.1387 20.2834
NOS-1 [Human HNSCC] GDSC1 1.8272 3.0979 1.6921 15.5539
ES4 GDSC1 1.8677 2.8115 1.8102 14.525
ES8 GDSC1 2.0712 3.1794 1.9323 12.5381
EW-16 GDSC1 2.1842 4.0826 1.6869 13.7439
HOS GDSC1 2.207 4.3777 1.5748 14.4772
EW-7 GDSC1 2.3071 3.3846 2.1126 9.997
EW-1 GDSC1 2.3917 3.6897 2.0733 9.8584
EW-18 GDSC1 2.3941 3.5591 2.1325 9.4087
EW-13 GDSC1 2.5061 3.269 2.3694 7.1116
A-673 GDSC1 2.5933 3.5064 2.3604 6.741
SK-ES-1 GDSC1 2.6256 3.5037 2.3943 6.3324
EW-24 GDSC1 2.6682 3.7887 2.3038 6.8232
ES1 GDSC1 2.7335 3.6731 2.4219 5.626
SJSA-1 GDSC1 2.75 4.132 2.2142 7.166
CAL-72 GDSC1 2.8111 16.1405 -3.7283 35.2732
ES5 GDSC1 2.8276 5.3294 1.6887 10.9688
SK-PN-DW GDSC1 2.8706 4.3129 2.2328 6.536
SaOS-2 GDSC1 2.9053 3.9991 2.4195 4.9333
MG-63 GDSC1 3.041 4.3759 2.3459 5.0119
U2OS GDSC1 3.0719 4.846 2.1362 6.5563
H-EMC-SS GDSC1 3.1225 7.1431 1.0297 14.8328
CHSA0011 GDSC1 3.2805 5.1151 2.1662 5.627
CAL-78 GDSC1 3.5148 11.1238 -0.6412 23.3534
EW-11 GDSC1 3.761 5.8449 2.1508 4.3895
HuO9 GDSC1 3.7962 5.8926 2.1512 4.2987
EW-3 GDSC1 4.0956 6.4143 2.0965 3.9964
CHSA8926 GDSC1 4.6115 6.6995 2.2579 2.0001
TC-71 GDSC1 4.8595 6.3994 2.49 0.5961
CHSA0108 GDSC1 5.7372 7.7737 2.3337 0.5891
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 2.3543 3.4711 2.1278 9.6433
MV4-11 GDSC1 0.2821 2.5537 0.1427 34.7966
MOLT-16 GDSC1 0.3067 2.4217 0.196 34.3297
ALL-PO GDSC1 0.7333 2.5789 0.6272 29.0066
ST486 GDSC1 0.8007 2.42 0.7297 27.9422
SR GDSC1 0.9544 2.8417 0.8087 26.5085
EoL-1 GDSC1 1.1158 2.7292 1.0108 24.2303
NKM-1 GDSC1 1.2147 2.727 1.1188 22.9358
BL-41 GDSC1 1.2823 2.1438 1.2726 21.5323
CTV-1 GDSC1 1.2942 3.0456 1.1258 22.4268
MC116 GDSC1 1.3551 2.7876 1.2581 21.1891
NALM-6 GDSC1 1.3944 2.7692 1.305 20.6486
WSU-DLCL2 GDSC1 1.4429 6.7043 -0.2688 30.0699
MY-M12 GDSC1 1.5113 2.4782 1.4824 18.7927
U-698-M GDSC1 1.5166 5.6187 0.3148 26.5416
SU-DHL-5 GDSC1 1.631 2.6516 1.5846 17.41
DND-41 GDSC1 1.6876 3.4875 1.4102 18.282
SIG-M5 GDSC1 1.6962 2.2198 1.6942 16.3101
ALL-SIL GDSC1 1.7394 3.5504 1.4427 17.7754
P30/OHK GDSC1 1.7703 4.7482 0.9683 21.0004
RS4;11 GDSC1 1.7877 3.2982 1.585 16.5136
SUP-B15 GDSC1 1.8505 4.1194 1.329 18.0184
THP-1 GDSC1 2.0057 3.2925 1.823 13.6593
P32/ISH GDSC1 2.0152 3.0731 1.9045 13.0417
KE-37 GDSC1 2.0241 3.0242 1.9282 12.8298
BC-1 GDSC1 2.0319 3.3466 1.832 13.4547
OCI-AML-2 GDSC1 2.032 3.3199 1.8417 13.3858
MOLM-13 GDSC1 2.0675 4.2962 1.4727 15.8993
Farage GDSC1 2.071 2.9967 1.987 12.1638
Reh GDSC1 2.0721 3.0847 1.963 12.3205
CA46 GDSC1 2.081 3.9063 1.6592 14.453
Karpas-620 GDSC1 2.0879 3.215 1.9386 12.4017
DEL GDSC1 2.1148 3.5958 1.8247 13.0721
VL51 GDSC1 2.1194 5.0815 1.1577 17.9823
HEL GDSC1 2.12 3.7437 1.769 13.4515
AMO1 GDSC1 2.126 3.065 2.0277 11.5747
GDM-1 GDSC1 2.1266 4.5371 1.4211 16.0029
SU-DHL-4 GDSC1 2.1382 2.7801 2.1092 10.9582
LP-1 GDSC1 2.1516 3.1983 2.0132 11.5326
NK-92MI GDSC1 2.1537 3.6843 1.8291 12.8418
Daudi GDSC1 2.1543 3.3034 1.9795 11.7543
MOLP-8 GDSC1 2.158 2.9388 2.097 10.9227
KCL-22 GDSC1 2.1784 3.2296 2.0316 11.2578
WSU-NHL GDSC1 2.1792 3.4359 1.9565 11.7866
MHH-PREB-1 GDSC1 2.1866 3.3245 2.0065 11.3901
QIMR-WIL GDSC1 2.1928 3.1138 2.0856 10.8027
LC4-1 GDSC1 2.2154 6.9128 0.3566 22.9758
NB4 GDSC1 2.2157 2.8582 2.1782 10.0459
Karpas-45 GDSC1 2.23 3.6697 1.9149 11.8291
OCI-Ly19 GDSC1 2.2307 3.1352 2.12 10.3543
Ramos.2G6.4C10 GDSC1 2.2459 3.3885 2.0459 10.7959
SUP-T1 GDSC1 2.2555 3.7939 1.8879 11.9015
Loucy GDSC1 2.2576 3.1608 2.1409 10.061
CESS GDSC1 2.2674 3.1769 2.1461 9.9711
RPMI-8402 GDSC1 2.2992 3.5142 2.0522 10.4743
TUR GDSC1 2.3089 3.2638 2.1602 9.647
VAL GDSC1 2.31 6.733 0.5313 21.4636
A4/Fukuda GDSC1 2.3253 3.0628 2.2456 8.9609
GR-ST GDSC1 2.3256 3.7031 1.9996 10.7296
SUP-HD1 GDSC1 2.3345 3.9209 1.9119 11.341
HC-1 GDSC1 2.3387 3.0975 2.2495 8.8591
Mono-Mac-6 GDSC1 2.3453 6.0644 0.893 18.8762
DoHH2 GDSC1 2.3588 3.1765 2.2452 8.7791
NU-DUL-1 GDSC1 2.3612 3.2537 2.2202 8.9423
WIL2 NS GDSC1 2.3687 3.373 2.1826 9.1716
Hs 445 GDSC1 2.3881 3.0885 2.3061 8.1943
A3/Kawakami GDSC1 2.391 3.2417 2.2566 8.5249
SU-DHL-16 GDSC1 2.4007 2.9504 2.3588 7.7645
697 GDSC1 2.404 6.376 0.7928 19.3203
Karpas-422 GDSC1 2.4064 2.9654 2.3612 7.7149
L-363 GDSC1 2.4069 3.3352 2.2381 8.5732
JJN-3 GDSC1 2.4179 3.9889 1.9642 10.554
HAL-01 GDSC1 2.4232 3.725 2.0898 9.5828
EB2 GDSC1 2.4295 4.7574 1.61 13.2077
IM-9 GDSC1 2.4488 4.1074 1.9395 10.5998
KOPN-8 GDSC1 2.4527 3.1433 2.3583 7.4753
CCRF-CEM GDSC1 2.4595 3.1965 2.3468 7.5199
BALL-1 GDSC1 2.4629 3.2854 2.3171 7.7136
SU-DHL-8 GDSC1 2.4895 3.0425 2.4307 6.7703
JSC-1 GDSC1 2.4925 3.3895 2.3066 7.6371
YT GDSC1 2.5132 3.1754 2.4123 6.768
EM-2 GDSC1 2.5166 3.8276 2.1369 8.7872
HT GDSC1 2.5168 3.2994 2.3688 7.0601
OCI-M1 GDSC1 2.5172 3.5916 2.2449 7.9708
BE-13 GDSC1 2.5276 3.9621 2.0849 9.1324
BV-173 GDSC1 2.5355 3.5119 2.2988 7.4802
ML-2 GDSC1 2.56 3.2589 2.4307 6.3902
SUP-M2 GDSC1 2.5743 2.9576 2.5463 5.5036
L-540 GDSC1 2.5918 3.3359 2.4328 6.2124
SCC-3 GDSC1 2.6109 3.0961 2.5457 5.3015
RPMI-8866 GDSC1 2.6257 3.4638 2.4123 6.1961
KM-H2 GDSC1 2.6263 3.2192 2.5168 5.4249
Karpas-231 GDSC1 2.628 3.2392 2.5106 5.4607
PL-21 GDSC1 2.6385 3.6229 2.3528 6.5844
ATN-1 GDSC1 2.648 3.2588 2.5237 5.2625
EHEB GDSC1 2.6636 3.7949 2.2964 6.9012
PF-382 GDSC1 2.6747 4.0394 2.1894 7.6777
EJM GDSC1 2.7151 3.6857 2.3981 5.8902
L-428 GDSC1 2.7196 3.6299 2.429 5.6337
MEG-01 GDSC1 2.7431 4.7932 1.8813 9.7968
HDLM-2 GDSC1 2.746 6.5329 1.0176 16.3399
RPMI-6666 GDSC1 2.7585 15.7317 -3.5682 35.115
HL-60 GDSC1 2.7631 3.4334 2.5641 4.4043
Jiyoye GDSC1 2.7705 4.6579 1.9728 8.9715
KMOE-2 GDSC1 2.7791 3.8275 2.3903 5.6728
NOMO-1 GDSC1 2.7872 3.4125 2.5976 4.0386
MOLT-4 GDSC1 2.8037 3.6601 2.4948 4.7573
DB GDSC1 2.8546 4.3079 2.2212 6.6899
SK-MM-2 GDSC1 2.8581 4.0061 2.3743 5.4738
BC-3 GDSC1 2.8669 4.5008 2.136 7.3112
ARH-77 GDSC1 2.8737 4.7371 2.0241 8.166
KG-1 GDSC1 2.8939 3.8926 2.4625 4.6396
JVM-2 GDSC1 2.9036 4.4254 2.2055 6.624
H9 GDSC1 2.905 3.8986 2.4693 4.543
MLMA GDSC1 2.9106 4.5404 2.1541 7.0023
Ku812 GDSC1 2.9289 4.3998 2.24 6.2562
TK [Human B-cell lymphoma] GDSC1 2.9523 3.9324 2.4935 4.171
SU-DHL-6 GDSC1 2.9794 4.2859 2.3398 5.282
SU-DHL-1 GDSC1 2.9961 4.3954 2.2991 5.5419
OCI-AML-5 GDSC1 3.0015 3.8203 2.5911 3.2192
Sc-1 GDSC1 3.0211 4.101 2.467 4.1275
U266B1 GDSC1 3.0423 4.4378 2.316 5.2431
Karpas-299 GDSC1 3.044 4.0012 2.5356 3.5064
Namalwa GDSC1 3.0542 4.1533 2.4679 4.0042
KMS-12-BM GDSC1 3.0581 4.556 2.2699 5.5515
P12-Ichikawa GDSC1 3.0629 4.0028 2.55 3.3272
OPM-2 GDSC1 3.0752 4.5797 2.2719 5.4756
K-562 GDSC1 3.14 4.3247 2.4504 3.8529
HH [Human lymphoma] GDSC1 3.156 11.2675 -1.0045 26.2151
L-1236 GDSC1 3.1752 5.8556 1.7154 9.4957
RC-K8 GDSC1 3.1759 4.7895 2.2473 5.3292
MN-60 GDSC1 3.2249 4.5227 2.417 3.8451
LAMA-84 GDSC1 3.2346 5.0817 2.1477 5.9183
RL GDSC1 3.2568 4.3616 2.5195 2.9547
RPMI-8226 GDSC1 3.2719 4.9249 2.2537 4.9713
JURL-MK1 GDSC1 3.2836 5.0572 2.1971 5.3761
ROS-50 GDSC1 3.3277 4.7978 2.3574 3.9976
OCI-AML-3 GDSC1 3.5803 5.9735 1.9648 6.2823
CTB-1 GDSC1 3.6043 6.2092 1.8669 6.9608
Raji GDSC1 3.8752 5.3557 2.4468 2.0321
ME1 GDSC1 4.1073 5.3377 2.5744 0.9073
P31/FUJ GDSC1 4.2201 7.5163 1.6598 6.8417
JVM-3 GDSC1 4.36 7.1808 1.9049 4.7655
KY821 GDSC1 4.5763 9.1159 1.135 9.6348
Granta-519 GDSC1 4.589 6.8215 2.1946 2.4129
DG-75 GDSC1 5.1436 7.038 2.3672 0.8615
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1 0.555 3.8168 0.0712 33.3965
KYSE-50 GDSC1 1.6786 3.6939 1.323 18.9462
HCE-4 GDSC1 2.4485 4.8771 1.5698 13.4332
KYSE-220 GDSC1 3.0297 4.2133 2.4179 4.4844
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 2.482 3.8701 2.0829 9.3566
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-SH GDSC1 1.6319 2.957 1.5185 17.8432
SK-N-MC-IXC GDSC1 1.974 2.8406 1.9194 13.1783
SJNB-7 GDSC1 2.0604 3.4861 1.8104 13.4568
CHP-212 GDSC1 2.0974 3.1162 1.9809 12.0561
SJNB-13 GDSC1 2.4253 3.6756 2.1139 9.3932
NB69 GDSC1 2.5256 3.5496 2.2722 7.7264
NB1 GDSC1 2.5822 4.3317 1.9604 9.848
NH-12 GDSC1 2.7233 3.6231 2.4358 5.5644
SJNB-14 GDSC1 2.7368 4.3935 2.0734 8.3201
IMR-5 GDSC1 2.7377 3.9418 2.2959 6.5818
NB(TU)1 GDSC1 2.7402 4.0014 2.2691 6.7797
SK-N-BE(2)-M17 GDSC1 2.8785 4.2568 2.2677 6.2315
KP-N-YS GDSC1 2.8944 4.4334 2.1935 6.7534
SK-N-DZ GDSC1 2.9615 10.53 -0.7971 26.0164
MHH-NB-11 GDSC1 2.9662 4.2643 2.3394 5.3333
SJNB-5 GDSC1 2.9714 3.9101 2.5209 3.8836
CHP-126 GDSC1 2.9929 5.6669 1.6606 10.5681
SJNB-10 GDSC1 3.0165 4.6674 2.1801 6.4067
GOTO GDSC1 3.0363 4.4615 2.2992 5.3966
TGW GDSC1 3.1413 4.2877 2.4698 3.6969
SiMa GDSC1 3.1533 5.2243 2.0128 7.246
Kelly GDSC1 3.3634 5.533 2.0221 6.4891
LA-N-6 GDSC1 3.3701 6.306 1.6444 9.3922
KP-N-YN GDSC1 3.4603 5.544 2.0882 5.6841
GI-ME-N GDSC1 3.503 5.9218 1.9342 6.7442
SJNB-12 GDSC1 3.8801 5.7447 2.2733 3.2181
SJNB-6 GDSC1 4.3599 6.0727 2.3944 1.5688
SK-N-FI GDSC1 4.5525 6.1053 2.4719 0.931
SK-N-AS GDSC1 4.8168 6.6674 2.3688 1.1522
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 2.1343 3.4795 1.8917 12.4865
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EFM-192A GDSC1 -0.9341 1.9157 -1.0533 49.2479
HCC1806 GDSC1 -0.3712 4.8561 -1.3117 44.6231
OCUB-M GDSC1 -0.1623 3.8895 -0.7293 41.7291
CAL-85-1 GDSC1 0.5243 3.7298 0.0688 33.6059
MCF-7 GDSC1 0.5808 2.3432 0.5058 30.7098
ZR-75-30 GDSC1 0.8735 9.1334 -1.9795 38.7743
HCC1569 GDSC1 0.9278 5.0649 -0.0326 31.6728
HCC1187 GDSC1 0.9619 3.2432 0.7049 27.1406
HCC38 GDSC1 1.1093 13.1038 -3.7028 40.8503
AU565 GDSC1 1.1631 3.3361 0.8944 24.7299
MDA-MB-361 GDSC1 1.589 3.8057 1.184 20.4024
MDA-MB-157 GDSC1 1.6044 3.4502 1.334 19.2664
CAL-51 GDSC1 1.6918 8.3088 -0.8104 31.2763
HCC1937 GDSC1 1.8639 3.4112 1.6277 15.8001
JIMT-1 GDSC1 1.8865 3.9149 1.4533 16.934
MDA-MB-330 GDSC1 2.1401 3.4854 1.8955 12.4287
HCC1954 GDSC1 2.2262 3.025 2.1486 10.1832
EFM-19 GDSC1 2.2742 4.1138 1.7634 12.7429
HCC70 GDSC1 2.2858 3.0396 2.2094 9.4314
DU4475 GDSC1 2.3896 2.9377 2.3497 7.8892
MRK-nu-1 GDSC1 2.4743 3.1763 2.37 7.2764
HCC1599 GDSC1 2.479 3.199 2.3669 7.2732
HCC2157 GDSC1 2.505 3.7955 2.1403 8.8153
HCC1500 GDSC1 2.5691 3.8304 2.1875 8.1602
HDQ-P1 GDSC1 2.6619 4.1455 2.1259 8.2244
COLO 824 GDSC1 2.7756 4.8319 1.8909 9.5919
HCC1395 GDSC1 2.7891 3.7764 2.4246 5.3645
MDA-MB-436 GDSC1 2.8354 3.942 2.3856 5.4764
HCC202 GDSC1 2.867 6.2914 1.2422 14.2272
MDA-MB-175-VII GDSC1 2.8982 4.0633 2.3813 5.2608
MDA-MB-468 GDSC1 3.0097 4.3117 2.3522 5.0742
BT-549 GDSC1 3.0239 5.381 1.8293 9.1389
CAMA-1 GDSC1 3.0765 4.2094 2.4578 4.007
HCC1419 GDSC1 3.0779 4.3849 2.3713 4.6831
MDA-MB-231 GDSC1 3.1686 8.0753 0.6014 17.6042
CAL-120 GDSC1 3.19 4.4879 2.4079 4.0253
HCC2218 GDSC1 3.2376 4.9624 2.2091 5.4286
BT-474 GDSC1 3.3295 5.3922 2.0662 6.2526
Hs 578T GDSC1 3.3388 9.1922 0.1815 19.6068
Evsa-T GDSC1 3.4151 5.4201 2.1161 5.603
BT-20 GDSC1 3.4508 14.6599 -2.4587 30.3103
BT-483 GDSC1 3.8734 5.6513 2.3122 2.9583
MFM-223 GDSC1 4.0522 5.335 2.5491 1.1141
UACC-893 GDSC1 4.1146 7.8622 1.4234 8.8285
HCC1428 GDSC1 4.2798 10.3598 0.3245 15.705
MDA-MB-453 GDSC1 4.6398 9.9418 0.7823 11.8173
CAL-148 GDSC1 4.6988 6.5211 2.3733 1.2575
UACC-812 GDSC1 4.9312 6.4935 2.484 0.5691
MDA-MB-415 GDSC1 5.6427 19.4025 -3.1165 26.3313
T-47D GDSC1 6.634 17.8951 -1.6799 19.3392
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-566MG GDSC1 0.7511 2.9961 0.5468 29.4064
A-172 GDSC1 1.2561 2.8351 1.1392 22.5573
GI-1 GDSC1 1.5152 3.3953 1.2567 20.292
D-423MG GDSC1 1.5485 3.7664 1.1563 20.8121
SF295 GDSC1 1.7251 3.3823 1.4883 17.5304
D-392MG GDSC1 1.8782 6.5353 0.2283 25.2795
T98G GDSC1 1.8819 2.9418 1.7952 14.542
8-MG-BA GDSC1 1.9315 3.131 1.7956 14.2583
YKG-1 GDSC1 1.9517 6.5343 0.298 24.5227
GaMG GDSC1 1.9542 3.2838 1.7703 14.3088
MOG-G-CCM GDSC1 1.9767 3.4247 1.7441 14.3723
Daoy GDSC1 2.1683 10.4117 -1.4199 31.5198
Becker GDSC1 2.1899 3.8103 1.8132 12.7774
Onda 11 GDSC1 2.2464 4.9631 1.3366 16.0858
NMC-G1 GDSC1 2.2886 5.8524 0.9449 18.7573
SNB-75 GDSC1 2.2961 6.5404 0.6137 20.9879
SF268 GDSC1 2.3002 3.4395 2.0835 10.2427
KS-1 [Human Krukenberg tumour] GDSC1 2.3067 12.8154 -2.4968 34.1868
SW1783 GDSC1 2.3553 4.2622 1.775 12.2787
SK-MG-1 GDSC1 2.408 3.3194 2.2454 8.5157
Hs 683 GDSC1 2.4228 3.4965 2.1889 8.8498
H4 GDSC1 2.4389 3.1604 2.3374 7.6974
SF539 GDSC1 2.4709 3.4337 2.2655 8.0462
M059J GDSC1 2.5147 6.0156 1.0708 16.8913
LN-18 GDSC1 2.5276 4.3749 1.8879 10.6451
MOG-G-UVW GDSC1 2.6128 5.4087 1.4595 13.5882
DBTRG-05MG GDSC1 2.6834 3.8875 2.271 7.0088
YH-13 GDSC1 2.7292 4.4861 2.0208 8.7621
LN-229 GDSC1 2.7862 3.6932 2.4623 5.0845
U-251MG GDSC1 2.8356 3.8004 2.4557 4.928
D-542MG GDSC1 2.8385 4.7766 1.9738 8.6964
GB-1 GDSC1 2.8685 3.842 2.4649 4.7217
D283 Med GDSC1 2.8979 3.8172 2.5035 4.3017
KNS-42 GDSC1 2.9499 7.2537 0.8313 16.8669
CAS-1 GDSC1 2.9885 6.8579 1.0615 15.0957
SF126 GDSC1 3.085 4.6148 2.2623 5.5178
U-87MG ATCC GDSC1 3.1274 4.2444 2.4805 3.6588
LN-405 GDSC1 3.2303 8.5059 0.4365 18.4398
KALS-1 GDSC1 3.2359 6.6289 1.3782 11.8685
U-118MG GDSC1 3.5658 6.4815 1.7053 8.3093
LNZTA3WT4 GDSC1 3.5989 5.696 2.1126 5.1029
PFSK-1 GDSC1 3.6349 6.5224 1.7358 7.87
AM-38 GDSC1 3.6926 5.2654 2.3793 2.8821
DK-MG GDSC1 3.7302 4.9526 2.5441 1.6574
ONS-76 GDSC1 3.7461 5.2926 2.3997 2.6173
42-MG-BA GDSC1 3.9342 10.3171 0.0878 18.1597
KNS-81-FD GDSC1 4.2977 8.6617 1.1641 10.1707
Onda 10 GDSC1 4.454 8.8014 1.2033 9.4816
D-263MG GDSC1 4.9019 6.3732 2.5166 0.4751
D-502MG GDSC1 5.0691 7.383 2.1987 1.726
SW1088 GDSC1 6.1275 19.7157 -2.9165 24.6482
KINGS-1 GDSC1 7.031 16.8157 -0.9069 15.2923
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 2.2569 3.7528 1.9072 11.7518
TGBC24TKB GDSC1 2.4191 3.7328 2.0821 9.66
TGBC1TKB GDSC1 2.8646 4.0881 2.3394 5.722
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-296 GDSC1 0.4903 6.9839 -1.3366 39.1706
MFE-319 GDSC1 0.7522 4.2872 0.1057 31.9861
AN3-CA GDSC1 1.2998 3.6574 0.931 23.7168
ESS-1 GDSC1 2.23 3.8202 1.8502 12.3063
EN GDSC1 3.0595 4.7163 2.1909 6.1685
MFE-280 GDSC1 3.4029 5.2725 2.1796 5.1487
KLE GDSC1 3.5439 11.8896 -1 24.8713
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW GDSC1 0.7219 3.1884 0.4599 30.1235
LB1047-RCC GDSC1 0.8891 3.4595 0.5563 28.5187
ACHN GDSC1 1.3212 3.9323 0.8497 24.1493
LB996-RCC GDSC1 1.5168 4.8933 0.6465 24.4649
786-O GDSC1 1.5904 2.9738 1.4688 18.4162
TK-10 GDSC1 1.6928 4.0855 1.1795 19.8935
BB65-RCC GDSC1 1.7191 4.3826 1.0793 20.4729
769-P GDSC1 1.7244 2.8189 1.6528 16.4082
RXF 393L GDSC1 1.8575 3.9005 1.4291 17.2572
LB2241-RCC GDSC1 1.9336 4.7207 1.1445 18.9499
Caki-1 GDSC1 2.0575 6.3497 0.4869 22.8694
SW13 GDSC1 2.1365 7.2151 0.1356 24.6362
OS-RC-2 GDSC1 2.17 3.9653 1.7249 13.5298
A-704 GDSC1 2.4768 3.7638 2.1265 9.0518
UO-31 GDSC1 2.5601 5.031 1.5981 12.7431
RCC10RGB GDSC1 2.6794 5.6461 1.4011 13.764
VMRC-RCZ GDSC1 2.7012 4.3312 2.0715 8.4819
HA7-RCC GDSC1 2.7383 4.8111 1.868 9.9196
SW156 GDSC1 2.8846 4.3348 2.2341 6.4719
BFTC-909 GDSC1 2.9082 4.5104 2.167 6.9096
KMRC-1 GDSC1 3.7716 9.2374 0.4987 16.2021
CAL-54 GDSC1 3.954 7.996 1.2456 10.5641
A-498 GDSC1 4.0695 5.661 2.4196 1.8627
SN12C GDSC1 4.0961 6.1551 2.2152 3.1664
KMRC-20 GDSC1 4.6503 9.3073 1.0929 9.7311
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW48 GDSC1 0.9312 2.1436 0.9058 26.0209
HCC2998 GDSC1 1.0994 3.6627 0.7134 26.2911
LoVo GDSC1 1.102 3.0863 0.9045 25.0139
T84 GDSC1 1.2115 4.0058 0.7043 25.7207
RKO GDSC1 1.324 3.1462 1.129 22.2353
KM12 GDSC1 1.7606 3.0847 1.6234 16.3985
LS411N GDSC1 1.774 3.4266 1.5253 17.006
SNU-C2B GDSC1 1.9652 6.0443 0.5481 22.9042
GP5d GDSC1 2.0298 3.1084 1.9098 12.9233
COLO205 GDSC1 2.0538 2.7872 2.0168 12.0651
SW620 GDSC1 2.1852 2.9037 2.1351 10.5107
HCT 15 GDSC1 2.1852 3.084 2.0865 10.8388
SW626 GDSC1 2.2354 4.4317 1.5778 14.3225
HT-29 GDSC1 2.453 3.3122 2.2961 7.9155
NCI-H747 GDSC1 2.4725 4.5898 1.7318 12.0863
LS180 GDSC1 2.4799 3.9149 2.06 9.5405
LS123 GDSC1 2.5153 6.3978 0.882 18.2348
LS1034 GDSC1 2.5231 3.3567 2.3521 7.1493
CCK-81 GDSC1 2.5642 4.1947 2.0095 9.5473
HCT 116 GDSC1 2.7902 4.1695 2.2323 6.8596
COLO 320HSR GDSC1 2.8988 3.8843 2.4709 4.5541
RCM-1 [Human ESC] GDSC1 2.8988 3.6566 2.584 3.6669
HT115 GDSC1 3.0873 4.1359 2.5031 3.6139
SW948 GDSC1 3.1422 4.98 2.1259 6.395
C2BBe1 GDSC1 3.2867 5.1995 2.1291 5.8965
SW1417 GDSC1 3.3883 5.0148 2.295 4.3019
SW837 GDSC1 3.4941 10.3469 -0.2703 21.5781
MDST8 GDSC1 3.5373 5.7175 2.0588 5.6859
NCI-H716 GDSC1 3.9524 5.8483 2.2695 3.0889
LS513 GDSC1 3.9899 6.7446 1.8745 5.8544
COLO 678 GDSC1 4.062 8.5873 1.0343 11.7395
HT-55 GDSC1 4.6769 14.6562 -1.4965 23.462
SNU-C1 GDSC1 5.2875 6.9407 2.4607 0.4393
CW-2 GDSC1 5.5523 7.5445 2.3448 0.6593
SW1463 GDSC1 5.5797 16.7574 -1.8653 22.4885
CL-11 GDSC1 5.7213 7.5301 2.4144 0.3706
CaR-1 GDSC1 6.5308 16.8036 -1.2274 17.7501
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.1539 4.6574 2.2958 5.0207
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC1 0.0435 3.1956 -0.2819 38.5797
SNU-423 GDSC1 1.3949 3.3446 1.1434 21.7379
HLE GDSC1 1.4851 3.2451 1.2738 20.3404
Hep-G2/C3A GDSC1 1.5205 13.1223 -3.3415 38.7907
SNU-387 GDSC1 1.6192 3.5344 1.3196 19.2874
JHH-7 GDSC1 1.7116 2.9406 1.6096 16.7715
SNU-449 GDSC1 1.8319 4.2632 1.2474 18.7023
JHH-1 GDSC1 1.9361 2.9723 1.8463 13.8866
JHH-4 GDSC1 1.992 2.9729 1.9073 13.1546
JHH-6 GDSC1 2.0543 4.048 1.57 15.2423
Hep 3B2.1-7 GDSC1 2.1673 3.5383 1.9034 12.2312
SK-HEP-1 GDSC1 2.2204 4.0786 1.7254 13.2828
Huh-7 GDSC1 2.8445 4.5879 2.073 7.8937
JHH-2 GDSC1 2.9395 4.0849 2.4064 4.9052
SNU-475 GDSC1 3.3107 4.3505 2.5629 2.4714
HuH-1 GDSC1 4.5847 6.0448 2.5094 0.7321
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H727 GDSC1 -1.225 6.3065 -2.7996 51.4767
NCI-H2122 GDSC1 -0.7008 1.8348 -0.7906 46.4883
NCI-H1355 GDSC1 -0.2054 7.7522 -2.3848 45.0267
NCI-H1975 GDSC1 0.345 3.8809 -0.1781 36.0083
CAL-12T GDSC1 0.5602 2.6811 0.4172 31.3862
DMS 273 GDSC1 0.6348 2.4478 0.5459 30.1248
SW1271 GDSC1 0.7313 2.9043 0.5495 29.5094
NCI-H358 GDSC1 0.9051 4.1488 0.3225 29.8493
IA-LM GDSC1 1.0029 7.5149 -1.0802 35.6337
LCLC-97TM1 GDSC1 1.0593 2.1912 1.036 24.406
Lu-135 GDSC1 1.1453 4.0261 0.626 26.5987
HCC827 GDSC1 1.15 3.0696 0.9616 24.3567
NCI-H2228 GDSC1 1.2354 7.1083 -0.6617 32.8819
NCI-H3122 GDSC1 1.2542 3.4817 0.9444 23.8798
NCI-H847 GDSC1 1.3394 4.903 0.4613 26.5764
PaCa-3 GDSC1 1.4431 3.0914 1.2751 20.5681
SBC-3 GDSC1 1.4834 2.7456 1.4068 19.4525
COR-L105 GDSC1 1.4963 4.5605 0.7725 23.7362
NCI-H2869 GDSC1 1.5058 4.9494 0.6102 24.7581
LK-2 GDSC1 1.5422 3.1848 1.355 19.4635
SBC-5 GDSC1 1.6209 8.8191 -1.126 32.8087
NCI-H2804 GDSC1 1.6547 3.8486 1.2367 19.6841
NCI-H2342 GDSC1 1.6793 3.4128 1.4281 18.2012
PC-14 GDSC1 1.7092 7.1099 -0.2097 28.4694
SK-MES-1 GDSC1 1.711 3.5346 1.4182 18.1
SK-LU-1 GDSC1 1.7247 5.0409 0.7888 22.4655
NCI-H2170 GDSC1 1.7268 5.1917 0.7213 22.9101
LC-2/ad GDSC1 1.7302 2.8187 1.6592 16.332
NCI-H810 GDSC1 1.747 4.9812 0.8385 22.016
NCI-H1944 GDSC1 1.8084 6.3249 0.2637 25.4021
NCI-H2722 GDSC1 1.8383 6.9598 -0.0153 26.8414
NCI-H1299 GDSC1 1.902 9.097 -1.0058 31.113
NCI-H1869 GDSC1 1.9174 4.8666 1.061 19.6276
NCI-H441 GDSC1 1.9246 5.2644 0.8818 20.8577
NCI-H1648 GDSC1 1.9531 5.9964 0.5598 22.8852
NCI-H2405 GDSC1 1.9631 3.6647 1.6367 15.2138
Calu-6 GDSC1 2.0107 3.0905 1.8943 13.137
LCLC-103H GDSC1 2.0341 3.5178 1.7701 13.8843
NCI-H2172 GDSC1 2.0367 16.9012 -4.7688 39.2592
NCI-H1437 GDSC1 2.0405 4.02 1.568 15.3248
NCI-H2803 GDSC1 2.0625 6.1328 0.5971 22.1371
NCI-H3255 GDSC1 2.0961 4.1092 1.5856 14.9228
RERF-LC-KJ GDSC1 2.1097 9.134 -0.8373 29.545
COLO 668 GDSC1 2.1123 4.1704 1.5747 14.926
ChaGo-K-1 GDSC1 2.1253 5.3289 1.0452 18.7699
NCI-H1770 GDSC1 2.1327 3.505 1.88 12.5793
COR-L23 GDSC1 2.136 2.919 2.0779 11.1777
NCI-H2087 GDSC1 2.1656 5.7056 0.9015 19.6077
NCI-H1915 GDSC1 2.2052 3.4633 1.9734 11.5291
NCI-H522 GDSC1 2.2415 4.8374 1.392 15.6933
NCI-H460 GDSC1 2.2461 5.635 1.0114 18.471
EBC-1 GDSC1 2.248 3.2644 2.0945 10.4388
NCI-H1734 GDSC1 2.2501 5.7948 0.9373 18.9801
IST-SL2 GDSC1 2.2924 4.1136 1.7817 12.5195
HCC44 GDSC1 2.2925 3.0639 2.2095 9.393
NCI-H2009 GDSC1 2.3254 3.6514 2.0217 10.5665
NCI-H1435 GDSC1 2.3275 4.408 1.6792 13.1329
A-427 GDSC1 2.3392 3.224 2.2073 9.1522
NCI-H64 GDSC1 2.3456 2.9163 2.3068 8.4315
HOP-62 GDSC1 2.3635 3.2935 2.2079 9.0176
NCI-H1781 GDSC1 2.3933 3.6923 2.0738 9.847
NCI-H2085 GDSC1 2.4316 3.8854 2.0256 10.026
NCI-H290 GDSC1 2.4375 3.1406 2.3427 7.6669
HCC78 GDSC1 2.4386 4.0581 1.9525 10.5476
NCI-H1755 GDSC1 2.4716 6.9806 0.5538 20.6308
NCI-H1568 GDSC1 2.518 3.6536 2.2179 8.1688
EPLC-272H GDSC1 2.5225 3.6781 2.2114 8.1963
NCI-H1650 GDSC1 2.5316 12.8802 -2.3357 32.9727
NCI-H2030 GDSC1 2.5696 7.5883 0.338 21.5867
NCI-H520 GDSC1 2.5846 4.2672 1.9939 9.5791
NCI-H647 GDSC1 2.6118 3.5644 2.353 6.7081
NCI-H2369 GDSC1 2.6227 4.9217 1.709 11.6269
NCI-H1688 GDSC1 2.6433 4.7016 1.8363 10.5531
NCI-H226 GDSC1 2.6889 3.6661 2.382 6.1312
NCI-H838 GDSC1 2.7054 3.2862 2.572 4.6202
Lu-99A GDSC1 2.7489 4.5763 1.9939 8.8924
NCI-H1703 GDSC1 2.757 4.0697 2.2512 6.849
LXF 289 GDSC1 2.7738 3.9574 2.3218 6.2288
NCI-H211 GDSC1 2.7912 4.2262 2.2053 7.0671
NCI-H596 GDSC1 2.8288 4.3924 2.1564 7.3
NCI-H1793 GDSC1 2.8349 3.7185 2.4953 4.6218
NCI-H1792 GDSC1 2.8596 3.8836 2.4364 4.9811
NCI-H2347 GDSC1 2.8836 5.6102 1.5967 11.4694
NCI-H2196 GDSC1 2.9039 6.0991 1.3697 13.1308
BEN GDSC1 2.921 3.7821 2.5413 3.9143
NCI-H2135 GDSC1 2.9262 5.3256 1.7752 9.9206
NCI-H661 GDSC1 2.9359 5.2567 1.8178 9.5508
NCI-H1048 GDSC1 2.9409 3.8478 2.5259 3.9593
ABC-1 GDSC1 2.957 9.8008 -0.4363 24.3429
NCI-H2461 GDSC1 2.958 6.0522 1.4388 12.4041
NCI-H1623 GDSC1 2.9662 8.8849 0.0294 21.8455
NCI-H1963 GDSC1 2.9797 4.3247 2.3206 5.4319
DMS 53 GDSC1 3.0125 5.3043 1.8583 8.9532
NCI-H1651 GDSC1 3.0194 5.3004 1.8659 8.8681
NCI-H196 GDSC1 3.0259 3.8286 2.6071 3.0064
Lu-134-A GDSC1 3.0487 4.8381 2.1212 6.7562
NCI-H2595 GDSC1 3.0583 5.1485 1.9739 7.8815
NCI-H1563 GDSC1 3.0694 4.2259 2.4439 4.1409
HCC15 GDSC1 3.0725 4.6355 2.2419 5.7213
Calu-3 GDSC1 3.083 4.3816 2.3771 4.6202
HARA [Human squamous cell lung carcinoma] GDSC1 3.1066 9.3125 -0.0679 21.8651
LOU-NH91 GDSC1 3.114 6.4942 1.347 12.5314
EKVX GDSC1 3.1156 7.3604 0.9154 15.6674
NCI-H1573 GDSC1 3.1268 5.9232 1.6426 10.2279
NCI-H2171 GDSC1 3.1344 4.4573 2.3801 4.4235
Ms-1 GDSC1 3.1887 4.795 2.2546 5.23
NCI-H510A GDSC1 3.1971 5.0515 2.1335 6.1522
NCI-H1092 GDSC1 3.2014 4.8325 2.2457 5.2582
IST-SL1 GDSC1 3.2214 4.9717 2.1921 5.6132
NCI-H292 GDSC1 3.2281 4.627 2.3679 4.218
Lu-165 GDSC1 3.2391 4.5238 2.427 3.7231
NCI-H1436 GDSC1 3.2685 4.8884 2.2692 4.8612
RERF-LC-MS GDSC1 3.2726 4.995 2.2196 5.2355
NCI-H841 GDSC1 3.2822 5.6672 1.8936 7.7492
NCI-H650 GDSC1 3.2884 13.5823 -2.0528 29.5992
NCI-H2081 GDSC1 3.3066 4.7958 2.343 4.171
HOP-92 GDSC1 3.3338 8.4623 0.5418 17.4018
NCI-H2731 GDSC1 3.3493 5.144 2.2033 5.1252
NCI-H2444 GDSC1 3.3584 7.0823 1.2493 12.4106
NCI-H23 GDSC1 3.3684 4.8674 2.3527 3.9158
NCI-H2141 GDSC1 3.3708 5.2571 2.1636 5.3685
NCI-H1581 GDSC1 3.396 4.8326 2.3891 3.5586
Lu-65 GDSC1 3.4042 5.7011 1.9697 6.7696
SHP-77 GDSC1 3.415 4.8068 2.4147 3.3123
SBC-1 GDSC1 3.4941 5.3381 2.2128 4.6307
DMS 114 GDSC1 3.5309 4.985 2.4074 3.0644
NCI-H526 GDSC1 3.549 6.065 1.8974 6.8895
NCI-H2373 GDSC1 3.5909 6.0113 1.9539 6.3346
NCI-H69 GDSC1 3.5937 5.7054 2.1044 5.179
NCI-H1694 GDSC1 3.6975 5.8024 2.1288 4.7163
UMC-11 GDSC1 3.6991 5.4237 2.3094 3.3737
LC-1/sq GDSC1 3.7211 5.5118 2.2822 3.5202
SW1573 GDSC1 3.7312 5.6006 2.2469 3.7542
NCI-H2795 GDSC1 3.7523 7.2693 1.4553 9.6295
RERF-LC-Sq1 GDSC1 3.8171 16.4691 -3.0664 30.8729
NCI-H1304 GDSC1 3.8443 5.6583 2.2912 3.1702
A-549 GDSC1 3.8892 5.756 2.2736 3.1959
NCI-H2029 GDSC1 3.9022 5.5244 2.3868 2.3832
NCI-H1836 GDSC1 3.9154 6.3002 2.0362 4.8513
NCI-H1155 GDSC1 3.9433 5.5238 2.4105 2.1451
COR-L88 GDSC1 3.9819 5.6768 2.3642 2.3804
LB647-SCLC GDSC1 4.0008 5.6137 2.4028 2.09
NCI-H2591 GDSC1 4.0074 13.4189 -1.3955 25.017
HCC33 GDSC1 4.049 6.266 2.1364 3.8167
CPC-N GDSC1 4.1325 7.7379 1.4955 8.2589
Lu-139 GDSC1 4.162 9.9603 0.4344 15.3859
COR-L95 GDSC1 4.1787 8.6006 1.1108 10.8723
NCI-H345 GDSC1 4.2049 5.1806 2.6777 0.3565
NCI-H524 GDSC1 4.2358 6.5553 2.1161 3.5628
NCI-H1876 GDSC1 4.2906 5.8653 2.4464 1.3696
NCI-H1838 GDSC1 4.3396 6.4022 2.243 2.5234
NCI-H2110 GDSC1 4.3857 6.7322 2.123 3.2224
NCI-H209 GDSC1 4.4099 9.8143 0.6843 13.0823
NCI-H446 GDSC1 4.5234 6.408 2.3358 1.6766
NCI-H187 GDSC1 4.6187 9.5093 0.9755 10.6014
NCI-H1693 GDSC1 4.6238 8.2868 1.5561 6.6106
NCI-H82 GDSC1 4.7783 6.0887 2.5717 0.3686
DMS 79 GDSC1 4.8073 6.6471 2.3726 1.1442
NCI-H2227 GDSC1 4.8251 7.0523 2.2169 1.9368
NCI-H2023 GDSC1 4.9097 6.6232 2.4265 0.8076
NCI-H720 GDSC1 4.93 6.4074 2.5152 0.4633
NCI-H513 GDSC1 5.3982 7.0888 2.4498 0.4169
NCI-H1993 GDSC1 5.4303 7.1553 2.4383 0.4343
NCI-H2818 GDSC1 5.5335 7.4528 2.3708 0.5846
NCI-H748 GDSC1 5.6148 7.4476 2.4039 0.4441
NCI-H1666 GDSC1 5.6854 7.7893 2.3077 0.7033
NCI-H2291 GDSC1 5.7322 7.3235 2.4897 0.2058
NCI-H322M GDSC1 5.7763 7.8999 2.3031 0.6645
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 2.786 3.9816 2.3212 6.1826
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-11 GDSC1 -1.7805 4.6397 -2.7416 55.777
TE-15 GDSC1 0.5821 4.5598 -0.183 34.4942
KYSE-140 GDSC1 0.6387 6.3671 -0.906 37.0327
TE-10 GDSC1 0.716 4.1035 0.1382 32.0304
KYSE-450 GDSC1 1.1914 5.5136 0.0379 29.8246
T.T GDSC1 1.519 3.1647 1.336 19.7242
OE19 GDSC1 1.5358 6.0827 0.1163 27.5904
TE-8 GDSC1 1.7252 4.1669 1.1788 19.7334
KYSE-270 GDSC1 1.8944 4.6213 1.1508 19.0936
KYSE-510 GDSC1 1.9415 2.8944 1.8718 13.6842
KYSE-70 GDSC1 1.9675 4.3052 1.3674 17.1602
OE21 GDSC1 2.2665 3.4785 2.0323 10.7865
OE33 GDSC1 2.2922 3.7422 1.9482 11.2745
TE-9 GDSC1 2.3156 3.8265 1.935 11.2589
KYSE-410 GDSC1 2.5459 3.2549 2.4173 6.5595
TE-5 GDSC1 2.5565 4.1337 2.0314 9.4129
TE-6 GDSC1 2.6815 3.6065 2.4028 6.0059
COLO 680N GDSC1 3.0126 4.831 2.0949 7.0919
TE-1 GDSC1 3.1312 4.5604 2.3262 4.8574
KYSE-180 GDSC1 3.2438 9.9266 -0.2623 22.4117
KYSE-150 GDSC1 3.3587 5.6888 1.9416 7.1302
EC-GI-10 GDSC1 4.1878 6.9706 1.8957 5.2187
KYSE-520 GDSC1 4.4812 6.7689 2.1598 2.8093
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IGROV-1 GDSC1 -0.1806 2.5335 -0.3558 40.5823
TYK-nu GDSC1 0.3771 4.0438 -0.2026 35.9066
A2780 GDSC1 0.4733 4.3714 -0.2238 35.3745
OVTOKO GDSC1 0.4821 5.2254 -0.5633 36.7416
OVCAR-8 GDSC1 1.185 7.8391 -1.0595 34.6406
TOV-112D GDSC1 1.3494 2.5431 1.2997 20.9502
Kuramochi GDSC1 1.7896 3.4842 1.5211 16.9523
SK-OV-3 GDSC1 2.1398 3.6032 1.8481 12.7735
EFO-21 GDSC1 2.2117 12.1451 -2.245 33.8737
EFO-27 GDSC1 2.243 3.0431 2.1617 9.9993
OVCAR-4 GDSC1 2.334 10.5405 -1.3387 30.5772
OAW42 GDSC1 2.4237 15.3759 -3.6745 36.354
OVCAR-5 GDSC1 2.4697 3.0776 2.3983 7.1039
FU-OV-1 GDSC1 2.4874 5.4408 1.3299 15.0898
OVISE GDSC1 2.5266 3.127 2.4438 6.4737
OVCAR-3 GDSC1 2.6921 4.2144 2.1204 8.1393
OC 314 GDSC1 2.7699 3.3576 2.6059 4.0555
OV-90 GDSC1 2.8599 4.1141 2.3223 5.8751
TOV-21G GDSC1 3.1378 4.3866 2.4179 4.115
RMG-I GDSC1 3.1775 5.7041 1.7929 8.8847
Caov-3 GDSC1 3.2195 4.2254 2.5592 2.7578
Caov-4 GDSC1 3.6185 8.4937 0.7501 15.0625
OAW28 GDSC1 3.6221 7.8777 1.0582 12.9233
ES-2 GDSC1 3.9851 6.1553 2.1482 3.8753
OVKATE GDSC1 4.3239 8.9101 1.0623 10.8036
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MIA PaCa-2 GDSC1 0.1513 2.4181 0.0285 36.3122
Panc 08.13 GDSC1 0.5537 28.785 -11.9839 47.0046
BxPC-3 GDSC1 0.9825 3.3574 0.6912 27.1083
KP-1N GDSC1 1.4113 3.4558 1.1233 21.7856
Panc 03.27 GDSC1 1.5938 10.0251 -1.7437 34.9238
PSN1 GDSC1 1.5954 5.404 0.4925 25.0524
KP-2 GDSC1 1.6087 2.8609 1.5172 17.986
Panc 10.05 GDSC1 1.7487 3.6839 1.4016 18.0176
HuP-T4 GDSC1 1.7575 3.4926 1.4836 17.3888
MZ-PC-1 GDSC1 1.9171 3.9101 1.4873 16.5326
KP-4 GDSC1 2.0293 3.3588 1.8249 13.5187
Capan-2 GDSC1 2.1432 5.4477 1.0051 18.9763
CFPAC-1 GDSC1 2.1548 4.5037 1.4646 15.547
PaTu 8988t GDSC1 2.1633 3.4172 1.9466 11.9407
Capan-1 GDSC1 2.4016 3.1668 2.2948 8.1984
Hs 766T GDSC1 2.4574 9.2782 -0.602 27.0736
HPAC GDSC1 2.5358 3.4114 2.3426 7.155
KP-3 GDSC1 2.711 4.9208 1.7892 10.644
PL4 GDSC1 2.7548 3.7743 2.3934 5.753
SUIT-2 GDSC1 2.9196 3.8942 2.4843 4.3679
PaTu 8902 GDSC1 3.0648 3.9793 2.5633 3.2166
SW1990 GDSC1 3.1471 4.7413 2.2487 5.4138
AsPC-1 GDSC1 3.1984 4.5323 2.3922 4.121
SU.86.86 GDSC1 3.207 7.5769 0.8817 15.5738
HuP-T3 GDSC1 3.2235 4.9505 2.2042 5.5115
Panc 04.03 GDSC1 3.3718 4.6962 2.4382 3.252
Panc 02.03 GDSC1 3.6117 5.1982 2.3593 3.2192
HPAF-II GDSC1 4.1323 9.13 0.8198 12.9935
YAPC GDSC1 4.8597 6.2367 2.5497 0.3928
DAN-G GDSC1 4.8744 6.7223 2.3729 1.0751
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC1 1.771 4.2533 1.189 19.428
MPP 89 GDSC1 2.2531 6.8571 0.4184 22.4273
NCI-H2052 GDSC1 2.4912 4.4178 1.8325 11.2303
IST-Mes1 GDSC1 2.6956 7.3348 0.574 19.5838
MSTO-211H GDSC1 3.9135 6.4903 1.9448 5.5295
NCI-H2452 GDSC1 5.7963 7.7944 2.3489 0.5132
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1 2.1886 3.1977 2.0536 11.0477
LNCaP clone FGC GDSC1 2.2184 3.3919 2.0152 11.1603
VCaP GDSC1 2.6392 3.4522 2.4312 5.9901
PC-3 GDSC1 2.9458 6.2744 1.3174 13.3683
22Rv1 GDSC1 4.0243 7.2244 1.6684 7.2833
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 2.8015 4.7025 1.9782 8.8059
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 940.T GDSC1 0.797 2.9043 0.6213 28.6574
A101D GDSC1 0.8942 7.0629 -0.9731 35.8426
HMV-II GDSC1 1.5626 7.7477 -0.6572 31.245
WM793 GDSC1 1.5822 3.5688 1.2672 19.8543
IGR-1 GDSC1 1.6164 3.2239 1.4234 18.5795
A-375 GDSC1 1.7481 3.2702 1.5515 16.9636
HT-144 GDSC1 1.7773 2.7578 1.7231 15.6331
A-431 GDSC1 1.9055 2.9672 1.8143 14.2784
MZ-MEL-2 GDSC1 1.9326 3.7065 1.5877 15.7249
WM35 GDSC1 1.9908 3.9654 1.5404 15.7747
A2058 GDSC1 2.0148 3.1402 1.8835 13.1885
Mel JuSo GDSC1 2.0227 5.341 0.9408 19.9844
IST-MEL1 GDSC1 2.0379 3.4719 1.7918 13.708
Mel Ho GDSC1 2.1163 15.2742 -3.8882 37.7016
451Lu GDSC1 2.1329 3.705 1.7987 13.1685
WM1552C GDSC1 2.1672 4.3992 1.5254 15.0335
LOX-IMVI GDSC1 2.1812 3.2418 2.0304 11.2513
RPMI-7951 GDSC1 2.1905 3.0708 2.0962 10.743
SK-MEL-2 GDSC1 2.2173 2.8127 2.1887 9.9676
LB2518-MEL GDSC1 2.2532 3.9788 1.8036 12.5412
IGR-37 GDSC1 2.3639 3.4596 2.1426 9.4864
G-361 GDSC1 2.3684 3.1227 2.2737 8.5277
CHL-1 GDSC1 2.3839 4.7531 1.5689 13.7211
COLO 679 GDSC1 2.4628 3.2902 2.3152 7.7274
SH-4 GDSC1 2.509 3.9557 2.0697 9.3333
WM278 GDSC1 2.5274 4.0685 2.0345 9.5185
CP50-MEL-B GDSC1 2.5654 5.3609 1.4404 13.9287
A-388 GDSC1 2.5662 3.3346 2.4066 6.533
MZ-MEL-7 GDSC1 2.5697 3.6127 2.2886 7.392
WT2-iPS GDSC1 2.5751 2.9383 2.5516 5.4636
GAK GDSC1 2.5816 4.546 1.8556 10.6618
Hs 938.T GDSC1 2.6063 3.6035 2.3296 6.9104
VMRC-MELG GDSC1 2.6134 3.6042 2.3363 6.8259
COLO 829 GDSC1 2.6594 3.9431 2.2213 7.4971
WM115 GDSC1 2.6982 4.9581 1.7593 10.9289
SK-MEL-24 GDSC1 2.7665 3.5551 2.51 4.8023
IPC-298 GDSC1 2.8061 9.5617 -0.4438 24.9501
G-mel GDSC1 2.916 12.613 -1.8767 30.2769
MMAc-SF GDSC1 2.9178 3.7609 2.549 3.8661
SK-MEL-30 GDSC1 2.9199 5.6213 1.622 11.1372
RVH-421 GDSC1 3.0004 4.6689 2.1658 6.5772
SK-MEL-3 GDSC1 3.0373 5.2996 1.8811 8.6848
LB373-MEL-D GDSC1 3.0457 6.6181 1.2289 13.66
SK-MEL-1 GDSC1 3.2526 4.3044 2.5445 2.7744
UACC-257 GDSC1 3.2899 4.4582 2.4961 3.0394
DJM-1 GDSC1 3.4746 5.3674 2.1847 4.9008
CP66-MEL GDSC1 3.5028 5.3917 2.1928 4.759
MeWo GDSC1 4.4353 7.9626 1.5886 6.8241
SK-MEL-28 GDSC1 4.5634 10.1085 0.6493 12.8795
M14 GDSC1 4.6447 16.4813 -2.4239 26.7839
SK-MEL-5 GDSC1 5.0174 6.4232 2.543 0.3346
COLO 783 GDSC1 5.0414 6.4202 2.553 0.2975
COLO 792 GDSC1 5.1645 6.6455 2.5193 0.3329
COLO 800 GDSC1 5.481 7.0597 2.4907 0.2799
UACC-62 GDSC1 5.9017 11.3278 0.9337 7.9363
EquiPSC Line K2 GDSC1 2.9692 7.8073 0.5706 18.5435
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 1.4485 2.5271 1.4085 19.6487
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW982 GDSC1 0.2459 3.5521 -0.1726 36.656
SW872 GDSC1 0.7991 3.0924 0.5722 28.9558
GCT GDSC1 1.5218 3.5492 1.2094 20.5848
SK-UT-1 GDSC1 1.6189 3.4017 1.3667 18.9596
G-401 GDSC1 1.7296 3.6191 1.4062 18.0862
A-204 GDSC1 2.0216 3.7266 1.6732 14.6489
Hs 633.T GDSC1 2.0651 3.0514 1.9653 12.3448
MES-SA GDSC1 2.2007 3.307 2.0281 11.1625
SK-LMS-1 GDSC1 2.233 3.526 1.9776 11.3554
STS-0421 GDSC1 2.2463 4.0257 1.7755 12.7845
MFH-ino GDSC1 2.3205 3.6218 2.0293 10.5355
HT-1080 GDSC1 2.3376 2.9318 2.2946 8.5593
EW-8 GDSC1 2.3546 3.5685 2.0874 9.9374
RD GDSC1 2.4177 3.3454 2.2455 8.4639
KYM-1 GDSC1 2.4401 2.9387 2.4045 7.2299
Rh30 GDSC1 2.5262 3.3699 2.35 7.1493
VA-ES-BJ GDSC1 2.5821 4.1265 2.0594 9.0846
RKN GDSC1 2.616 3.4496 2.4087 6.2704
TE 441.T GDSC1 2.6697 3.3427 2.5107 5.25
G-402 GDSC1 2.7816 8.9687 -0.1682 23.6362
Rh41 GDSC1 2.8289 3.6535 2.5217 4.4413
SW684 GDSC1 4.4163 5.9565 2.4691 1.091
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NUGC-4 GDSC1 0.9802 3.4666 0.6527 27.3701
TMK-1 GDSC1 1.0878 4.4497 0.3946 28.3668
HGC-27 GDSC1 1.4023 2.9353 1.2736 20.8118
MKN1 GDSC1 1.6726 5.9452 0.3144 25.7604
OCUM-1 GDSC1 1.7697 3.2427 1.584 16.6188
IM95 GDSC1 1.7769 3.4353 1.5253 16.9901
MKN28 GDSC1 1.8605 3.8541 1.4514 17.0808
Fu97 GDSC1 2.1227 3.3842 1.9157 12.3761
GCIY GDSC1 2.3481 4.3296 1.7364 12.605
SNU-1 GDSC1 2.5514 3.5621 2.2928 7.4478
RF-48 GDSC1 2.5634 3.6317 2.2737 7.5342
23132/87 GDSC1 2.6163 4.7031 1.8108 10.8635
AGS GDSC1 2.6864 4.1037 2.1691 7.7843
NUGC-3 GDSC1 2.8785 4.5943 2.0995 7.5542
TGBC11TKB GDSC1 2.9305 4.5006 2.1911 6.6357
MKN45 GDSC1 2.9604 4.4144 2.2596 5.9844
ECC10 GDSC1 3.0246 4.6071 2.2168 6.0878
SNU-5 GDSC1 3.1042 4.3973 2.3862 4.4769
NCI-N87 GDSC1 3.8159 7.3239 1.4746 9.2984
MKN7 GDSC1 3.8753 6.3387 1.9917 5.2795
HSC-39 GDSC1 4.2189 5.8215 2.4289 1.571
SNU-16 GDSC1 4.3963 5.7395 2.5459 0.7413
SCH GDSC1 4.6153 5.8029 2.6119 0.332
RERF-GC-1B GDSC1 5.0185 7.7753 2.0107 2.8558
SNG-M GDSC1 0.015 1.86 -0.0317 37.5815
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ASH-3 GDSC1 -0.3542 4.9351 -1.3246 44.5213
ML-1 [Human leukemia] GDSC1 0.828 2.3339 0.7727 27.5006
TT2609-C02 GDSC1 1.2907 3.077 1.113 22.5326
8505C GDSC1 1.5139 3.5933 1.1847 20.7996
IHH-4 GDSC1 1.778 3.0518 1.6519 16.1055
KMH-2 GDSC1 1.7972 2.9267 1.7066 15.626
B-CPAP GDSC1 1.8574 3.1748 1.7013 15.3216
HTC-C3 GDSC1 2.1705 3.5869 1.887 12.3334
CGTH-W-1 GDSC1 2.272 4.5559 1.5553 14.3252
8305C GDSC1 2.427 3.1096 2.3416 7.733
CAL-62 GDSC1 2.4562 3.8074 2.0859 9.455
K5 GDSC1 3.0314 6.5335 1.2594 13.4854
TT GDSC1 3.7144 6.8943 1.6113 8.5764
FTC-133 GDSC1 3.828 35.9298 -12.78 41.8623
WRO GDSC1 3.9915 13.0828 -1.2408 24.4478
BHT-101 GDSC1 6.9905 20.9669 -2.9144 22.783
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BICR 78 GDSC1 0.3189 3.6882 -0.1391 36.0013
BB49-HNC GDSC1 0.3319 14.9416 -5.3179 45.1529
KON GDSC1 0.9516 2.5468 0.8699 26.1275
OSC-19 GDSC1 1.1185 2.4878 1.0604 23.8897
NCI-H3118 GDSC1 1.21 2.676 1.1245 22.926
SAT [Human HNSCC] GDSC1 1.273 3.2542 1.0402 23.1259
BHY GDSC1 1.7389 3.1176 1.5899 16.7501
OSC-20 GDSC1 1.8162 2.6845 1.7785 15.0388
Ca9-22 GDSC1 1.8488 3.5389 1.5642 16.3308
SCC-25 GDSC1 1.8667 3.2866 1.6746 15.4558
CAL-27 GDSC1 1.8989 2.6894 1.8666 13.9704
BB30-HNC GDSC1 1.9002 2.8988 1.8258 14.2313
JHU-029 GDSC1 2.0442 3.648 1.7291 14.1275
Detroit 562 GDSC1 2.1069 3.4647 1.8683 12.7982
HSC-2 GDSC1 2.3137 2.9258 2.2698 8.8639
HO-1-u-1 GDSC1 2.3991 3.4119 2.1991 8.896
PCI-04B GDSC1 2.4107 3.3778 2.2252 8.6465
HO-1-N-1 GDSC1 2.4384 4.6103 1.6895 12.5598
PCI-06A GDSC1 2.5422 3.341 2.3787 6.858
HSC-3 GDSC1 2.6516 3.2884 2.5152 5.3073
PCI-15A GDSC1 2.6709 3.551 2.4182 5.9387
SCC-4 GDSC1 2.7059 19.4719 -5.4823 38.3425
SCC-9 GDSC1 2.7347 3.6518 2.4333 5.5331
SCC-15 GDSC1 2.8007 3.7709 2.4381 5.2104
HSC-4 GDSC1 2.8271 3.4655 2.6112 3.756
JHU-011 GDSC1 2.8284 4.0379 2.3319 5.9252
SAS GDSC1 2.8973 5.0134 1.9065 8.9999
CAL-33 GDSC1 2.9315 4.5136 2.1854 6.6771
PCI-38 GDSC1 2.9807 16.594 -3.813 34.9386
BICR 31 GDSC1 2.9879 4.1462 2.4167 4.644
KOSC-2 GDSC1 3.0464 5.6411 1.7179 9.9279
DOK GDSC1 3.1051 4.6621 2.2548 5.5073
BICR 10 GDSC1 3.2419 8.8293 0.2844 19.337
FaDu GDSC1 3.295 4.6787 2.392 3.827
LB771-HNC GDSC1 3.5037 8.2111 0.8014 15.0983
UPCI-SCC-090 GDSC1 3.5041 5.7961 1.9965 6.261
BICR 22 GDSC1 3.5282 4.9846 2.4059 3.0826
SKN-3 GDSC1 3.8311 9.1047 0.6096 15.3004
PCI-30 GDSC1 4.9701 6.6533 2.4403 0.7051
PE/CA-PJ15 GDSC1 5.7312 7.4431 2.4484 0.2881
JHU-022 GDSC1 6.0346 8.201 2.2941 0.5548
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1710 GDSC1 0.6883 3.0913 0.4516 30.3803
BFTC-905 GDSC1 1.524 3.0877 1.3644 19.5024
J82 GDSC1 1.7815 6.1207 0.336 25.0994
639V GDSC1 1.8188 2.9969 1.7118 15.4672
5637 GDSC1 2.3383 3.1599 2.2287 9.0062
HT-1197 GDSC1 2.467 3.6166 2.1826 8.6783
UM-UC-3 GDSC1 2.5117 4.1015 2.0035 9.8267
HT-1376 GDSC1 2.5479 3.8077 2.1772 8.3366
647V GDSC1 2.57 3.1781 2.4724 6.0382
RT-112 GDSC1 2.6899 3.9411 2.2513 7.1325
RT-4 GDSC1 2.7642 8.5921 0.0051 22.7581
TCCSUP GDSC1 2.912 3.8082 2.5204 4.1135
T24 GDSC1 3.3257 6.1418 1.6916 9.1739
CAL-29 GDSC1 3.4047 5.2389 2.1973 5.007
SW780 GDSC1 4.9515 6.9584 2.3145 1.2741
KU-19-19 GDSC1 4.9822 6.0157 2.6705 0.0863
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC1 0.2628 1.614 0.2486 34.3024
DoTc2 4510 GDSC1 1.0427 2.7789 0.92 25.2576
C-33 A GDSC1 1.0669 4.3941 0.3955 28.4798
OVMIU GDSC1 1.1443 6.7299 -0.5714 32.9805
LB831-BLC GDSC1 1.5277 4.3638 0.8898 22.7759
KGN GDSC1 1.5404 3.0639 1.3892 19.2402
HeLa GDSC1 1.6489 2.5545 1.6189 17.0796
BPH-1 GDSC1 2.162 3.3264 1.9793 11.7147
CAL-39 GDSC1 2.2642 3.2234 2.1266 10.1249
SiSo GDSC1 2.3233 6.8445 0.4883 21.6818
SW962 GDSC1 2.3921 3.2003 2.2728 8.4046
SKN GDSC1 2.4145 4.3846 1.7748 12.0121
NT2-D1 GDSC1 2.4801 3.1681 2.3792 7.18
C-4-I GDSC1 2.4963 4.8744 1.6158 12.8754
JEG-3 GDSC1 2.5145 3.3278 2.355 7.1724
NEC8 GDSC1 2.6482 3.5907 2.3772 6.3546
NCC-IT GDSC1 2.6508 3.6739 2.3411 6.6166
OMC-1 [Human cervical carcinoma] GDSC1 2.6746 3.6618 2.3701 6.2869
MS751 GDSC1 2.6996 6.7937 0.8473 17.7272
SW954 GDSC1 2.8297 3.7891 2.4559 4.9509
HT-3 GDSC1 2.9064 4.0127 2.4137 4.9742
Ca Ski GDSC1 2.9193 4.3849 2.2392 6.2984
DSH1 GDSC1 3.1214 5.2117 1.9936 7.5058
HEC-1 GDSC1 3.1443 5.931 1.653 10.0866
SW756 GDSC1 3.316 5.0757 2.2123 5.1576
SKG-IIIa GDSC1 3.3476 5.3674 2.092 5.995
SiHa GDSC1 4.6892 5.9424 2.5901 0.3596
ME-180 GDSC1 4.8504 11.3921 0.2281 14.663
JAR GDSC1 5.3957 6.7629 2.5621 0.1637
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5997).
2 The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
3 A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.