Details of the Drug

General Information of Drug (ID: DMQGO74)

Drug Name
ONO-3307
Synonyms 4-Guanidinobenzoic acid 4-sulfamoylphenyl ester methanesulfonate
Indication
Disease Entry ICD 11 Status REF
Coagulation defect 3B10.0 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 334.35
Logarithm of the Partition Coefficient (xlogp) 0.4
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C14H14N4O4S
IUPAC Name
(4-sulfamoylphenyl) 4-(diaminomethylideneamino)benzoate
Canonical SMILES
C1=CC(=CC=C1C(=O)OC2=CC=C(C=C2)S(=O)(=O)N)N=C(N)N
InChI
InChI=1S/C14H14N4O4S/c15-14(16)18-10-3-1-9(2-4-10)13(19)22-11-5-7-12(8-6-11)23(17,20)21/h1-8H,(H4,15,16,18)(H2,17,20,21)
InChIKey
YFUQTMNUQVFBBS-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
127139
ChEBI ID
CHEMBL4471405
CAS Number
76472-28-1
TTD ID
D02ALZ
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Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Protease unspecific (PRO) TTZBFA0 NOUNIPROTAC Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Inhibitory effects of ONO-3307 on various proteases and tissue thromboplastin in vitro and on experimental thrombosis in vivo. Jpn J Pharmacol. 1989 Dec;51(4):455-63.