Details of the Drug

General Information of Drug (ID: DMQH2DK)

Drug Name
CAR-GPC3 T Cells
Indication
Disease Entry ICD 11 Status REF
Lung squamous cell carcinoma 2C25.2 Phase 1 [1]
Hepatocellular carcinoma 2C12.02 Clinical trial [2]
Drug Type
CAR T Cell Therapy
Cross-matching ID
TTD ID
D0H4UP

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glypican-3 (GPC3) TTJTSX4 GPC3_HUMAN CAR-T-Cell-Therapy [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Lung squamous cell carcinoma
ICD Disease Classification 2C25.2
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glypican-3 (GPC3) DTT GPC3 5.54E-86 3 9.74
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT02876978) Anti-GPC3 CAR T for Recurrent or Refractory Lung Squamous Cell Carcinoma
2 ClinicalTrials.gov (NCT03146234) CAR-GPC3 T Cells in Patients With Refractory Hepatocellular Carcinoma