Details of the Drug

General Information of Drug (ID: DMQSGM0)

• Drug Name: Hydroxyamphetamine Hydrobromide
• Synonyms: Paredrine; 4-hydroxyamphetamine

Indication

Disease Entry	ICD 11	Status	REF
Horner syndrome	8D8A.1	Approved	[1]
Mydriasis	LA11.62	Approved	[2]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 232.12
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 2
  Hydrogen Bond Donor Count; 3
  Hydrogen Bond Acceptor Count; 2
• Chemical Identifiers:
  Formula: C9H14BrNO
  IUPAC Name: 4-(2-aminopropyl)phenol;hydrobromide
  Canonical SMILES: CC(CC1=CC=C(C=C1)O)N.Br
  InChI: InChI=1S/C9H13NO.BrH/c1-7(10)6-8-2-4-9(11)5-3-8;/h2-5,7,11H,6,10H2,1H3;1H
  InChIKey: RZCJLMTXBMNRAD-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 9377
  ChEBI ID: CHEMBL1200705
  CAS Number: 306-21-8
  TTD ID: D0W1RY
• Drug-Molecule Activity Atlas (DMA)NEW: Click to Jump to the Detailed DMA Information of This Drug
• Drug ADMET Endpoint Profile (DAE)NEW: Click to Jump to the Detailed DAE Information of This Drug
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Trace amine-associated receptor-1 (TAAR1)	TTIU98M	TAAR1_HUMAN	Modulator	[3]

Molecular Expression Atlas of This Drug

• The Studied Disease: Horner syndrome
• ICD Disease Classification: 8D8A.1

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Trace amine-associated receptor-1 (TAAR1)	DTT	TAAR1	6.12E-01	-0.01	-0.06

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Hydroxyamphetamine Hydrobromide FDA Label
• [3] Diagnostic pharmacology of the pupil.Clin Neuropharmacol.1985;8(1):27-37.