Details of the Drug

General Information of Drug (ID: DMQUFNY)

Drug Name
ARM210
Synonyms
Arm-210; UNII-1033GN605L; 1033GN605L; Rycal dmd; SCHEMBL15326996; ARM-210; JIGDAUOKKYKRKO-UHFFFAOYSA-N; s48168; S-48168; 4-((7-Methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl)benzoic acid; Benzoic acid, 4-((2,3-dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)methyl)-; 4-((7-methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)methyl)benzoic acid; 1467605-57-7
Indication
Disease Entry ICD 11 Status REF
Duchenne dystrophy 8C70 Phase 1 [1]
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 329.4
Logarithm of the Partition Coefficient (xlogp) 0.8
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C18H19NO3S
IUPAC Name
4-[(7-methoxy-3,5-dihydro-2H-1,4-benzothiazepin-4-yl)methyl]benzoic acid
Canonical SMILES
COC1=CC2=C(C=C1)SCCN(C2)CC3=CC=C(C=C3)C(=O)O
InChI
InChI=1S/C18H19NO3S/c1-22-16-6-7-17-15(10-16)12-19(8-9-23-17)11-13-2-4-14(5-3-13)18(20)21/h2-7,10H,8-9,11-12H2,1H3,(H,20,21)
InChIKey
JIGDAUOKKYKRKO-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
71761628
CAS Number
1467605-57-7
UNII
1033GN605L
DrugBank ID
DB16944
TTD ID
D0U1OO

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ryanodine receptor (RYR) TT9YXM1 NOUNIPROTAC Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)