Details of the Drug

General Information of Drug (ID: DMQXJDM)

Drug Name
Piroximone
Synonyms MDL-19205
Indication
Disease Entry ICD 11 Status REF
Cardiac failure BD10-BD13 Discontinued in Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 217.22
Logarithm of the Partition Coefficient (xlogp) 0.4
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C11H11N3O2
IUPAC Name
4-ethyl-5-(pyridine-4-carbonyl)-1,3-dihydroimidazol-2-one
Canonical SMILES
CCC1=C(NC(=O)N1)C(=O)C2=CC=NC=C2
InChI
InChI=1S/C11H11N3O2/c1-2-8-9(14-11(16)13-8)10(15)7-3-5-12-6-4-7/h3-6H,2H2,1H3,(H2,13,14,16)
InChIKey
OQGWJZOWLHWFME-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
55263
CAS Number
84490-12-0
UNII
27L0EP6IZK
DrugBank ID
DB15945
TTD ID
D08FOX

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase (PDE) TTUST1O NOUNIPROTAC Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000260)
2 Circulatory effects of the PDE-inhibitors piroximone and enoximone. Br J Clin Pharmacol. 1993 Oct;36(4):309-14.