Details of the Drug

General Information of Drug (ID: DMQXJDM)

Drug Name
Piroximone
Synonyms MDL-19205
Indication
Disease Entry ICD 11 Status REF
Cardiac failure BD10-BD13 Discontinued in Phase 3 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 217.22
Logarithm of the Partition Coefficient (xlogp) 0.4
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C11H11N3O2
IUPAC Name
4-ethyl-5-(pyridine-4-carbonyl)-1,3-dihydroimidazol-2-one
Canonical SMILES
CCC1=C(NC(=O)N1)C(=O)C2=CC=NC=C2
InChI
InChI=1S/C11H11N3O2/c1-2-8-9(14-11(16)13-8)10(15)7-3-5-12-6-4-7/h3-6H,2H2,1H3,(H2,13,14,16)
InChIKey
OQGWJZOWLHWFME-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
55263
ChEBI ID
CHEMBL58355
CAS Number
84490-12-0
UNII
27L0EP6IZK
DrugBank ID
DB15945
TTD ID
D08FOX
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Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase (PDE) TTUST1O NOUNIPROTAC Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000260)
2 Circulatory effects of the PDE-inhibitors piroximone and enoximone. Br J Clin Pharmacol. 1993 Oct;36(4):309-14.