Details of the Drug

General Information of Drug (ID: DMQXPJB)

• Drug Name: Ki-1769
• Synonyms: Ki-1769; Ki 1769; AC1L2ZHG; ki1769; SCHEMBL9214494; SCHEMBL6377119; CHEMBL310746; SUPZSNPDPSPMTK-UHFFFAOYSA-N; N-CYANO-N'-(2-PHENYLETHYL)-3-PYRIDINECARBOXIMIDAMIDE; N-cyano-N'-phenethylpyridine-3-carboximidamide; 3-Pyridinecarboximidamide, N-cyano-N'-(2-phenylethyl)-

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Terminated	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 250.3
  Logarithm of the Partition Coefficient (xlogp); 2.2
  Rotatable Bond Count (rotbonds); 5
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C15H14N4
  IUPAC Name: N-cyano-N'-(2-phenylethyl)pyridine-3-carboximidamide
  Canonical SMILES: C1=CC=C(C=C1)CCN=C(C2=CN=CC=C2)NC#N
  InChI: InChI=1S/C15H14N4/c16-12-19-15(14-7-4-9-17-11-14)18-10-8-13-5-2-1-3-6-13/h1-7,9,11H,8,10H2,(H,18,19)
  InChIKey: SUPZSNPDPSPMTK-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 131608
  CAS Number: 133300-00-2
  TTD ID: D0C8DC

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Potassium channel unspecific (KC)	TT1VOHK	NOUNIPROTAC	Opener	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002625)
• [2] Vasorelaxant action of Ki1769, a new pyridinecarboximidamide, in isolated porcine coronary artery. Eur J Pharmacol. 1993 Sep 14;241(2-3):177-81.