Details of the Drug

General Information of Drug (ID: DMRAP4S)

Drug Name
Acoramidis
Synonyms
Acoramidis; AG-10; Acoramidis [USAN]; AG10; 1446711-81-4; T12B44A1OE; 3-[3-(3,5-Dimethyl-1h-Pyrazol-4-Yl)propoxy]-4-Fluorobenzoic Acid; UNII-T12B44A1OE; CHEMBL3940890; 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid; WHO 11205; Benzoic acid, 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluoro-; 4hiq; ACORAMIDIS [INN]; ACORAMIDIS [WHO-DD]; SCHEMBL15816954; BDBM50197885; AKOS040759821; HY-109165; CS-0116350; E79901; Q27451739; 16V
Indication
Disease Entry ICD 11 Status REF
Transthyretin amyloid cardiomyopathy 5D00.20 Phase 3 [1]
Drug Type
Small molecule
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C15H17FN2O3
Canonical SMILES
CC1=C(C(=NN1)C)CCCOC2=C(C=CC(=C2)C(=O)O)F
InChI
InChI=1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)
InChIKey
WBFUHHBPNXWNCC-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
71464713
ChEBI ID
CHEMBL3940890
UNII
T12B44A1OE
DrugBank ID
DB17999
TTD ID
D5EHL4
Drug-Molecule Activity Atlas (DMA)NEW Click to Jump to the Detailed DMA Information of This Drug
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Transthyretin (TTR) TTC1I86 TTHY_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT03860935) A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of AG10 in Subjects With Symptomatic Transthyretin Amyloid Cardiomyopathy (ATTRibute-CM Trial). U.S.National Institutes of Health.
2 Clinical pipeline report, company report or official report of AstraZeneca