Details of the Drug

General Information of Drug (ID: DMRE4FC)

Drug Name
Arginine
Synonyms
DL-Arginine hydrochloride; 32042-43-6; 2-Amino-5-guanidinopentanoic acid hydrochloride; argininhydrochlorid; DL-Arginine HCl; 220144-84-3; H-DL-Arg-OH.xHCl; DL-(+/-)-Arginine Hydrochloride; 1-Hydrochloride arginine; NSC7914; Arginine monochloride; 2-Amino-5-guanidinovaleric acid monohydrochloride; WLN: MUYZM3YZVQ & DL-Arginine hydrochloride, 98%, anhydrous; Arginine monohydrochloride, L-(+)-; ARGININE, (L); L(+)-Arginine hydrochloride; D-Arginine, hydrochloride (1:1); EINECS 250-903-0; EINECS 239-674-8
Indication
Disease Entry ICD 11 Status REF
Growth hormone deficiency 5A61.3 Approved [1]
Affected Organisms
Humans and other mammals
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 174.2
Logarithm of the Partition Coefficient (xlogp) -4.2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
Bioavailability
68% of drug becomes completely available to its intended biological destination(s) [2]
Metabolism
The drug is not metabolised []
Chemical Identifiers
Formula
C6H14N4O2
IUPAC Name
(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid
Canonical SMILES
C(C[C@@H](C(=O)O)N)CN=C(N)N
InChI
InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
InChIKey
ODKSFYDXXFIFQN-BYPYZUCNSA-N
Cross-matching ID
PubChem CID
6322
ChEBI ID
CHEMBL1485
CAS Number
74-79-3
UNII
94ZLA3W45F
DrugBank ID
DB00125
TTD ID
D0F5DO
VARIDT ID
DR00188
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Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Mitochondrial ornithine transporter 2 (SLC25A2) DTDPJ3F ORNT2_HUMAN Substrate [3]
Sodium-coupled neutral amino acid transporter 9 (SLC38A9) DTF7MYK S38A9_HUMAN Substrate [4]
Mitochondrial ornithine transporter 3 (SLC25A29) DT96BT4 MCATL_HUMAN Substrate [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Critical Evaluation of Human Oral Bioavailability for Pharmaceutical Drugs by Using Various Cheminformatics Approaches
3 Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2. Amino Acids. 2016 Feb;48(2):427-36.
4 Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94.
5 The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84.