Details of the Drug

General Information of Drug (ID: DMRE4FC)

Drug Name

Arginine

Synonyms

DL-Arginine hydrochloride; 32042-43-6; 2-Amino-5-guanidinopentanoic acid hydrochloride; argininhydrochlorid; DL-Arginine HCl; 220144-84-3; H-DL-Arg-OH.xHCl; DL-(+/-)-Arginine Hydrochloride; 1-Hydrochloride arginine; NSC7914; Arginine monochloride; 2-Amino-5-guanidinovaleric acid monohydrochloride; WLN: MUYZM3YZVQ & DL-Arginine hydrochloride, 98%, anhydrous; Arginine monohydrochloride, L-(+)-; ARGININE, (L); L(+)-Arginine hydrochloride; D-Arginine, hydrochloride (1:1); EINECS 250-903-0; EINECS 239-674-8

Indication

Disease Entry	ICD 11	Status	REF
Growth hormone deficiency	5A61.3	Approved	[1]
------------------------------------------------------------------------------------

Affected Organisms

Humans and other mammals

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 1

Molecular Weight (mw)

174.2

Logarithm of the Partition Coefficient (xlogp)

-4.2

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

Bioavailability: 68% of drug becomes completely available to its intended biological destination(s) [2]
Metabolism: The drug is not metabolised []

Chemical Identifiers

Formula: C6H14N4O2
IUPAC Name: (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid
Canonical SMILES: C(C[C@@H](C(=O)O)N)CN=C(N)N
InChI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
InChIKey: ODKSFYDXXFIFQN-BYPYZUCNSA-N

Cross-matching ID

PubChem CID: 6322
ChEBI ID: CHEBI:16467
CAS Number: 74-79-3
UNII: 94ZLA3W45F
DrugBank ID: DB00125
TTD ID: D0F5DO
VARIDT ID: DR00188

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Mitochondrial ornithine transporter 2 (SLC25A2)	DTDPJ3F	ORNT2_HUMAN	Substrate	[3]
Sodium-coupled neutral amino acid transporter 9 (SLC38A9)	DTF7MYK	S38A9_HUMAN	Substrate	[4]
Mitochondrial ornithine transporter 3 (SLC25A29)	DT96BT4	MCATL_HUMAN	Substrate	[5]

------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Critical Evaluation of Human Oral Bioavailability for Pharmaceutical Drugs by Using Various Cheminformatics Approaches
3	Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2. Amino Acids. 2016 Feb;48(2):427-36.
4	Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94.
5	The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84.