Details of the Drug

General Information of Drug (ID: DMREQCF)

Drug Name
CAR-T Cells targeting EpCAM
Indication
Disease Entry ICD 11 Status REF
Colon cancer 2B90.Z Phase 1/2 [1]
Esophageal cancer 2B70 Phase 1/2 [1]
Gastric adenocarcinoma 2B72 Phase 1/2 [1]
Hepatocellular carcinoma 2C12.02 Phase 1/2 [1]
Pancreatic cancer 2C10 Phase 1/2 [1]
Prostate cancer 2C82.0 Phase 1/2 [1]
Metastatic cancer 2D50-2E2Z Phase 1 [2]
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Drug Type
CAR T Cell Therapy
Cross-matching ID
TTD ID
D08QYW
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor-associated calcium signal transducer 1 (EPCAM) TTZ8WH4 EPCAM_HUMAN CAR-T-Cell-Therapy [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Colon cancer
ICD Disease Classification 2B90.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tumor-associated calcium signal transducer 1 (EPCAM) DTT EPCAM 5.99E-02 -0.11 -1.11
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT03013712) A Clinical Research of CAR T Cells Targeting EpCAM Positive Cancer
2 ClinicalTrials.gov (NCT03563326) Intraperitoneal Infusion of EpCAM CAR-T Cell in Advanced Gastric Cancer With Peritoneal Metastasis (WCH-GC-CART)