Details of the Drug

General Information of Drug (ID: DMRPI2Q)

Drug Name
Tapinarof
Synonyms GSK-2894512; GSK2894512
Indication
Disease Entry ICD 11 Status REF
Plaque psoriasis EA90.0 Approved [1]
Atopic dermatitis EA80 Phase 2 [2]
Psoriasis vulgaris EA90 Phase 2 [3]
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C17H18O2
Canonical SMILES
CC(C)C1=C(C=C(C=C1O)C=CC2=CC=CC=C2)O
InChI
1S/C17H18O2/c1-12(2)17-15(18)10-14(11-16(17)19)9-8-13-6-4-3-5-7-13/h3-12,18-19H,1-2H3/b9-8+
InChIKey
ZISJNXNHJRQYJO-CMDGGOBGSA-N
Cross-matching ID
PubChem CID
6439522
CAS Number
79338-84-4
UNII
84HW7D0V04
DrugBank ID
DB06083
TTD ID
D03DMB
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aryl hydrocarbon receptor (AHR) TT037IE AHR_HUMAN Agonist [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215272.
2 ClinicalTrials.gov (NCT02564042) A Dose-Finding Study of GSK2894512 Cream in Subjects With Plaque Psoriasis.
3 ClinicalTrials.gov (NCT01098734) Non-steroid, Atopic Dermatitis Phase IIb 12-week Trial; Topical WBI-1001 Cream. U.S. National Institutes of Health.