Details of the Drug

General Information of Drug (ID: DMRPI2Q)

Drug Name
Tapinarof
Synonyms GSK-2894512; GSK2894512
Indication
Disease Entry ICD 11 Status REF
Plaque psoriasis EA90.0 Approved [1]
Atopic dermatitis EA80 Phase 2 [2]
Psoriasis vulgaris EA90 Phase 2 [3]
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C17H18O2
Canonical SMILES
CC(C)C1=C(C=C(C=C1O)C=CC2=CC=CC=C2)O
InChI
InChI=1S/C17H18O2/c1-12(2)17-15(18)10-14(11-16(17)19)9-8-13-6-4-3-5-7-13/h3-12,18-19H,1-2H3/b9-8+
InChIKey
ZISJNXNHJRQYJO-CMDGGOBGSA-N
Cross-matching ID
PubChem CID
6439522
ChEBI ID
CHEMBL259571
CAS Number
79338-84-4
UNII
84HW7D0V04
DrugBank ID
DB06083
TTD ID
D03DMB
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Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aryl hydrocarbon receptor (AHR) TT037IE AHR_HUMAN Agonist [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215272.
2 ClinicalTrials.gov (NCT02564042) A Dose-Finding Study of GSK2894512 Cream in Subjects With Plaque Psoriasis.
3 ClinicalTrials.gov (NCT01098734) Non-steroid, Atopic Dermatitis Phase IIb 12-week Trial; Topical WBI-1001 Cream. U.S. National Institutes of Health.