Details of the Drug

General Information of Drug (ID: DMS29M4)

Drug Name
TWS-119
Synonyms
TWS119; 601514-19-6; TWS-119; 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol; TWS 119; GSK inhibitor XII; GSK-3beta Inhibitor XII, TWS119; Neurogenesis Inducer, TWS119; CHEMBL405759; 3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol; 3-((6-(3-AMINOPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)OXY)PHENOL; 3-{[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}phenol; Phenol, 3-[[6-(3-aminophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-; K00245; MLS006011018; GTPL5980; SCHEMBL5559045; GSK-3BETA INHIB
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 318.3
Logarithm of the Partition Coefficient (xlogp) 3.2
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C18H14N4O2
IUPAC Name
3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
Canonical SMILES
C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
InChI
InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChIKey
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9549289
ChEBI ID
CHEBI:91384
CAS Number
601514-19-6
TTD ID
D0T8KR

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glycogen synthase kinase-3 beta (GSK-3B) TTRSMW9 GSK3B_HUMAN Inhibitor [2]
Proto-oncogene c-Myc (MYC) TTZILNJ MYC_HUMAN Inhibitor [2]
Transcription factor AP-1 (JUN) TTN3GBV JUN_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glycogen synthase kinase-3 beta (GSK-3B) DTT GSK3B 1.26E-01 -0.23 -0.77
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 4.6049 6.799 3.3106 7.0052
H-EMC-SS GDSC1 0.2198 5.3017 -0.4561 50.8918
EW-13 GDSC1 0.3647 2.9363 0.2877 49.4993
NY GDSC1 0.8223 1.8318 0.8218 43.748
NOS-1 [Human HNSCC] GDSC1 0.9678 5.3703 0.3297 43.8802
U2OS GDSC1 1.1273 3.0792 1.0799 40.1833
G-292 clone A141B1 GDSC1 1.3595 3.4473 1.2789 37.4858
ES7 GDSC1 1.5285 4.0631 1.34 35.9868
EW-18 GDSC1 1.9227 3.1448 1.908 30.0829
EW-22 GDSC1 2.1052 5.0391 1.6749 30.3964
HuO9 GDSC1 2.1493 4.4508 1.9144 28.6577
ES5 GDSC1 2.4593 4.5691 2.2167 24.8741
A-673 GDSC1 2.7137 4.4685 2.5246 21.3511
EW-16 GDSC1 2.7415 6.2733 1.8436 25.7736
ES8 GDSC1 2.7821 4.3998 2.6196 20.318
ES1 GDSC1 2.861 4.365 2.7156 19.2185
SaOS-2 GDSC1 2.8896 5.3748 2.384 21.3721
MHH-ES-1 GDSC1 2.8966 4.12 2.8165 18.3353
CHSA8926 GDSC1 2.9553 5.3866 2.448 20.579
EW-1 GDSC1 2.9784 4.4474 2.8196 17.8455
HOS GDSC1 3.0524 4.9119 2.7401 17.9962
CAL-78 GDSC1 3.1106 4.5556 2.9295 16.3511
SK-PN-DW GDSC1 3.1227 5.5288 2.5618 18.9129
SK-ES-1 GDSC1 3.1395 4.3662 3.0192 15.5723
ES4 GDSC1 3.2087 6.5548 2.1817 21.1908
HuO-3N1 GDSC1 3.2725 7.5314 1.7764 23.5674
TC-71 GDSC1 3.3266 4.712 3.1088 13.9195
EW-3 GDSC1 3.4583 5.8658 2.7497 15.9076
EW-24 GDSC1 3.6053 5.9229 2.8669 14.3512
CADO-ES1 GDSC1 3.6664 4.6984 3.4775 9.4925
EW-7 GDSC1 3.8128 5.3543 3.3379 9.825
MG-63 GDSC1 4.0145 7.2155 2.6116 14.5529
ES6 GDSC1 4.3489 7.4931 2.7587 12.1655
SJSA-1 GDSC1 4.3644 5.9035 3.5663 5.8076
CAL-72 GDSC1 4.4573 6.7418 3.2229 8.1849
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 152 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 3.1525 4.7086 2.9225 16.171
BV-173 GDSC1 -2.5314 0.0061 -2.5375 81.155
LAMA-84 GDSC1 -2.4157 -0.5861 -2.4162 82.1574
ALL-SIL GDSC1 -2.2117 -0.1402 -2.2136 79.425
EM-2 GDSC1 -2.016 3.6983 -2.4351 68.1712
MY-M12 GDSC1 -1.8933 3.4625 -2.2471 68.0189
MEG-01 GDSC1 -1.4784 0.6746 -1.4837 71.304
SU-DHL-16 GDSC1 -1.4574 0.5433 -1.4606 71.3089
K-562 GDSC1 -1.1525 2.285 -1.2443 65.4628
KCL-22 GDSC1 -0.9344 1.9991 -0.9855 64.0151
JURL-MK1 GDSC1 -0.5732 0.9081 -0.5741 61.1107
SU-DHL-6 GDSC1 -0.5521 1.1073 -0.5544 60.7906
RCH-ACV GDSC1 -0.4293 4.3134 -0.8609 56.8133
SUP-B15 GDSC1 -0.4204 4.086 -0.7911 56.9351
DoHH2 GDSC1 -0.1609 1.4412 -0.164 55.9816
CTV-1 GDSC1 -0.1249 1.6329 -0.131 55.5061
SU-DHL-5 GDSC1 -0.083 1.2627 -0.0839 55.0461
EoL-1 GDSC1 -0.034 1.6837 -0.0399 54.3942
KG-1 GDSC1 0.2075 3.4182 0.0423 51.2558
RPMI-8866 GDSC1 0.5057 3.6698 0.3154 47.972
GDM-1 GDSC1 0.5953 5.2865 -0.0441 47.4942
QIMR-WIL GDSC1 0.755 5.5344 0.0417 46.0782
Jurkat GDSC1 0.7982 5.1867 0.2098 45.4712
MV4-11 GDSC1 0.8937 2.7109 0.8679 42.9741
A4/Fukuda GDSC1 1.1897 2.157 1.189 39.1574
SIG-M5 GDSC1 1.3303 2.8238 1.3138 37.4942
P32/ISH GDSC1 1.408 2.5453 1.4043 36.447
NK-92MI GDSC1 1.4318 4.7528 1.0404 38.0986
MOLT-16 GDSC1 1.4547 3.3785 1.3909 36.2153
NU-DUL-1 GDSC1 1.5112 4.3509 1.2466 36.5836
MOLT-4 GDSC1 1.6072 2.8423 1.5983 33.9896
NALM-6 GDSC1 1.6357 4.3802 1.3743 35.0767
BC-1 GDSC1 1.6435 2.8111 1.6367 33.5224
Karpas-45 GDSC1 1.6587 4.496 1.3662 34.9652
NB4 GDSC1 1.7053 3.2369 1.6734 32.9056
Ku812 GDSC1 1.7936 3.8133 1.6831 32.2854
Karpas-231 GDSC1 1.8305 5.504 1.2085 34.6288
ST486 GDSC1 1.884 3.1699 1.8661 30.5867
RPMI-6666 GDSC1 1.9769 5.9789 1.1764 33.8623
OCI-Ly19 GDSC1 1.9854 4.8959 1.595 31.5966
P30/OHK GDSC1 2.0185 5.1643 1.5365 31.7258
VAL GDSC1 2.0307 6.0992 1.1834 33.5001
JSC-1 GDSC1 2.0812 4.7886 1.7349 30.182
NKM-1 GDSC1 2.1435 3.9864 2.027 27.9735
OCI-AML-2 GDSC1 2.1806 3.4449 2.1534 26.9379
697 GDSC1 2.2218 5.1268 1.769 29.1333
MC116 GDSC1 2.2275 3.2007 2.2197 26.2291
TUR GDSC1 2.2402 3.6011 2.1987 26.2846
MOLM-13 GDSC1 2.2666 3.9462 2.1691 26.3163
WIL2 NS GDSC1 2.2675 5.4479 1.6964 29.3041
KE-37 GDSC1 2.2979 3.5737 2.2634 25.5194
ML-2 GDSC1 2.3664 3.8413 2.2972 24.8866
YT GDSC1 2.3872 3.9778 2.2936 24.786
SUP-M2 GDSC1 2.474 5.5743 1.8649 27.0898
CTB-1 GDSC1 2.509 6.3393 1.5769 28.639
U-698-M GDSC1 2.5388 4.1539 2.4192 23.0651
Ramos.2G6.4C10 GDSC1 2.5533 4.7177 2.2708 23.9779
BL-41 GDSC1 2.5706 3.8559 2.5148 22.2486
ALL-PO GDSC1 2.5854 4.7499 2.2948 23.6346
RPMI-8402 GDSC1 2.6603 4.4021 2.486 21.916
MOLT-13 GDSC1 2.6642 4.237 2.5353 21.5625
RS4;11 GDSC1 2.7582 4.0169 2.6879 19.9991
KOPN-8 GDSC1 2.7904 3.6861 2.7718 19.2614
NOMO-1 GDSC1 2.7919 4.3877 2.6338 20.1658
CCRF-CEM GDSC1 2.7936 4.3006 2.6598 19.9807
SUP-T1 GDSC1 2.8273 5.7013 2.1819 23.0963
Farage GDSC1 2.8505 10.5418 -0.0857 34.1839
SU-DHL-4 GDSC1 2.9045 5.3197 2.4221 21.0265
A3/Kawakami GDSC1 2.9087 5.2256 2.4647 20.7053
Hs 445 GDSC1 2.9463 8.7057 0.8995 29.9062
L-540 GDSC1 2.9542 5.6004 2.3566 21.2291
Reh GDSC1 2.9847 4.5601 2.7912 18.0057
BE-13 GDSC1 3.0089 7.017 1.7686 24.8814
PF-382 GDSC1 3.0605 6.2727 2.166 22.0195
IM-9 GDSC1 3.0752 5.35 2.5887 18.9602
P12-Ichikawa GDSC1 3.1915 5.1704 2.7852 16.9485
DB GDSC1 3.2735 5.8891 2.5548 18.2214
HH [Human lymphoma] GDSC1 3.2837 6.3661 2.3439 19.6953
Jiyoye GDSC1 3.2904 5.1118 2.9131 15.516
U266B1 GDSC1 3.2921 5.2333 2.864 15.8659
Loucy GDSC1 3.3282 4.5875 3.1549 13.5863
CESS GDSC1 3.3374 5.2037 2.9237 15.2008
GA-10 GDSC1 3.3716 5.7235 2.7288 16.4728
KY821 GDSC1 3.4194 5.2055 3.008 14.1733
ATN-1 GDSC1 3.4253 6.1294 2.5939 17.2179
BALL-1 GDSC1 3.4501 5.1172 3.0776 13.5086
Karpas-620 GDSC1 3.4951 4.9683 3.1873 12.4782
DEL GDSC1 3.522 6.3491 2.5834 16.8526
JJN-3 GDSC1 3.5374 5.4617 3.0146 13.5522
BC-3 GDSC1 3.5505 5.9998 2.7772 15.2764
HC-1 GDSC1 3.6084 8.1748 1.7727 22.0787
Mono-Mac-6 GDSC1 3.6218 6.5717 2.5711 16.499
SR GDSC1 3.6268 5.1434 3.2483 11.375
L-363 GDSC1 3.6424 4.7211 3.443 9.8659
TK [Human B-cell lymphoma] GDSC1 3.6692 7.0387 2.3875 17.6385
HDLM-2 GDSC1 3.6729 6.382 2.7112 15.2272
LP-1 GDSC1 3.6744 5.5718 3.1 12.2682
HAL-01 GDSC1 3.7503 8.8592 1.5609 22.7702
HEL GDSC1 3.8018 5.8256 3.1023 11.6806
HL-60 GDSC1 3.8165 5.9565 3.0529 11.9974
SKM-1 GDSC1 3.8183 6.9668 2.5595 15.7425
OCI-AML-5 GDSC1 3.8361 5.2825 3.3944 9.2878
OCI-M1 GDSC1 3.8672 5.3546 3.3906 9.1764
RPMI-8226 GDSC1 3.8825 4.9335 3.6018 7.5008
THP-1 GDSC1 3.9129 6.5322 2.8598 13.0774
P31/FUJ GDSC1 3.9129 5.7682 3.2349 10.1775
LC4-1 GDSC1 3.9223 8.5778 1.8524 20.2507
EHEB GDSC1 3.9514 6.8434 2.7405 13.832
L-428 GDSC1 3.9673 5.5139 3.4096 8.5914
SUP-HD1 GDSC1 3.9807 7.4444 2.4679 15.7542
VL51 GDSC1 3.9953 8.7402 1.835 20.0673
DND-41 GDSC1 4.0661 7.3605 2.5845 14.5514
SCC-3 GDSC1 4.186 5.012 3.858 4.1832
EB2 GDSC1 4.2285 8.3308 2.2391 16.4322
CA46 GDSC1 4.2338 7.5794 2.6192 13.646
H9 GDSC1 4.2718 6.6965 3.0926 9.868
MLMA GDSC1 4.2902 8.3432 2.2848 15.8763
SU-DHL-1 GDSC1 4.2927 5.445 3.7359 4.7289
OPM-2 GDSC1 4.3003 6.1798 3.3749 7.5465
Sc-1 GDSC1 4.3043 6.0059 3.4652 6.8204
Karpas-299 GDSC1 4.3602 6.8297 3.0998 9.4897
RC-K8 GDSC1 4.3836 6.7553 3.1562 8.9647
AMO1 GDSC1 4.4282 6.2815 3.4292 6.6644
KM-H2 GDSC1 4.4814 6.1751 3.5247 5.7329
PL-21 GDSC1 4.5401 6.6246 3.347 6.9319
Karpas-422 GDSC1 4.559 8.3209 2.5164 13.2307
KMS-12-BM GDSC1 4.5765 7.0184 3.1796 8.1205
EJM GDSC1 4.6564 8.0993 2.7043 11.5014
SU-DHL-10 GDSC1 4.6741 6.8886 3.319 6.7196
GR-ST GDSC1 4.7176 7.9752 2.8137 10.4726
OCI-AML-3 GDSC1 4.7403 6.6816 3.47 5.3459
KMS-11 GDSC1 4.7849 6.2667 3.7031 3.4365
WSU-DLCL2 GDSC1 4.8338 6.2405 3.7484 2.9707
HT GDSC1 4.898 6.6617 3.5903 3.9865
WSU-NHL GDSC1 5.0334 6.7484 3.638 3.2961
L-1236 GDSC1 5.0514 8.061 3.02 7.8794
Granta-519 GDSC1 5.082 9.1669 2.5 11.6317
SU-DHL-8 GDSC1 5.1422 8.125 3.0531 7.3723
RL GDSC1 5.2291 7.4942 3.4131 4.4687
Raji GDSC1 5.2551 6.8984 3.7032 2.3599
JVM-3 GDSC1 5.3349 7.2181 3.6056 2.8655
MOLP-8 GDSC1 5.3573 7.6421 3.4249 4.0846
MHH-PREB-1 GDSC1 5.6185 8.1022 3.3719 3.8928
SK-MM-2 GDSC1 5.8047 7.6525 3.6699 1.6636
MN-60 GDSC1 5.9877 7.6581 3.7536 1.0072
ROS-50 GDSC1 5.99 9.169 3.107 4.9395
ME1 GDSC1 6.1292 7.3945 3.9104 0.3055
DG-75 GDSC1 6.2628 8.0608 3.7174 0.9126
KMOE-2 GDSC1 6.4551 15.4247 0.4323 19.6651
Daudi GDSC1 6.7079 8.0802 3.8822 0.1693
ARH-77 GDSC1 7.0421 8.5501 3.8397 0.1615
JVM-2 GDSC1 7.2132 9.374 3.6146 0.633
⏷ Show the Full List of 152 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1 2.189 9.5017 -0.206 37.6802
KYAE-1 GDSC1 2.3309 4.542 2.0852 26.485
KYSE-220 GDSC1 2.495 7.4625 1.0541 31.4686
OACP4 C GDSC1 2.5078 5.6074 1.8871 26.7607
FLO-1 GDSC1 2.5262 5.9193 1.7762 27.3534
HCE-4 GDSC1 2.9374 4.2454 2.8312 17.9998
ESO-26 GDSC1 2.9496 5.3396 2.4614 20.5139
KYSE-50 GDSC1 3.0551 6.9275 1.856 24.103
OACM5.1 C GDSC1 4.3388 6.5393 3.2273 8.5683
SK-GT-4 GDSC1 4.5955 7.3627 3.0231 9.2727
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 4.7064 6.4666 3.5507 4.8236
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC1 -0.4859 1.8264 -0.5075 59.6147
NH-12 GDSC1 0.333 4.037 0.0431 49.885
SiMa GDSC1 0.6103 5.7923 -0.2076 47.5145
MHH-NB-11 GDSC1 0.8786 4.8046 0.4221 44.3977
SK-N-SH GDSC1 1.0189 5.4188 0.3677 43.3973
SJNB-12 GDSC1 1.2707 3.4472 1.1836 38.6132
SJNB-14 GDSC1 1.3216 5.9932 0.477 40.8859
SJNB-10 GDSC1 1.3848 3.4124 1.3113 37.135
KP-N-YS GDSC1 1.4282 4.0666 1.2298 37.2504
SJNB-17 GDSC1 1.7332 5.8871 0.9559 36.4
NB(TU)1 GDSC1 1.9185 7.9443 0.2573 37.7864
SJNB-7 GDSC1 1.9224 4.538 1.6412 31.7207
SK-N-FI GDSC1 1.983 6.7387 0.8617 35.2329
IMR-5 GDSC1 2.0977 5.3735 1.5439 31.2005
KP-N-YN GDSC1 2.1316 7.8963 0.4923 35.8001
SK-N-MC-IXC GDSC1 2.232 3.1762 2.2255 26.1649
SK-N-BE(2)-M17 GDSC1 2.2442 11.3655 -1.0524 39.3949
SK-N-DZ GDSC1 2.2589 6.0466 1.444 30.8003
NB1 GDSC1 2.5377 5.5944 1.9238 26.3612
GI-ME-N GDSC1 2.6405 6.072 1.8289 26.4035
CHP-134 GDSC1 2.6485 6.489 1.6527 27.4387
GOTO GDSC1 2.6737 7.2379 1.3355 29.0989
SJNB-5 GDSC1 2.7005 4.6302 2.4595 21.8695
Kelly GDSC1 2.8806 4.6295 2.6554 19.5209
SJNB-6 GDSC1 3.0052 8.5468 1.0321 28.9918
LA-N-6 GDSC1 3.598 11.9019 -0.087 31.0545
SJNB-13 GDSC1 4.0058 7.4008 2.5117 15.3306
SK-N-AS GDSC1 5.4282 9.0003 2.8281 8.2511
CHP-212 GDSC1 6.9198 22.0975 -2.5046 28.2716
TGW GDSC1 7.0151 13.628 1.6762 11.8285
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 2.2888 5.4487 1.7187 29.0466
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC38 GDSC1 0.2981 2.909 0.2203 50.2778
Hs 578T GDSC1 0.6433 2.8368 0.5944 46.1292
OCUB-M GDSC1 1.3392 3.4716 1.2533 37.7636
MDA-MB-468 GDSC1 1.4147 3.3346 1.3542 36.693
HCC1187 GDSC1 1.5111 3.3333 1.457 35.4593
EFM-19 GDSC1 1.5397 7.5899 0.0334 40.6434
MFM-223 GDSC1 1.8012 4.7701 1.4367 33.6501
MRK-nu-1 GDSC1 1.9245 3.7951 1.8282 30.5717
HDQ-P1 GDSC1 2.0639 5.6463 1.4021 32.185
HCC1599 GDSC1 2.3387 3.852 2.2653 25.2599
BT-474 GDSC1 2.3475 5.7912 1.6431 29.1587
DU4475 GDSC1 2.3711 3.3976 2.3569 24.4746
HCC1806 GDSC1 2.4103 4.337 2.2316 25.0587
HCC1395 GDSC1 2.4152 5.4908 1.8363 27.5999
HCC1569 GDSC1 2.6489 4.7373 2.3679 22.783
MDA-MB-361 GDSC1 2.7043 6.3532 1.7701 26.4291
MDA-MB-157 GDSC1 2.7177 5.3016 2.2321 23.3352
AU565 GDSC1 2.7589 4.3013 2.6218 20.4356
MDA-MB-453 GDSC1 2.9411 5.7278 2.2882 21.775
MCF-7 GDSC1 3.0046 5.4682 2.4653 20.203
BT-549 GDSC1 3.0205 4.4915 2.852 17.3867
MDA-MB-175-VII GDSC1 3.0331 5.8221 2.3413 20.9362
CAMA-1 GDSC1 3.1841 7.3481 1.7806 23.9575
COLO 824 GDSC1 3.2226 5.308 2.76 16.9736
HCC1937 GDSC1 3.2898 5.6055 2.6993 17.0853
UACC-893 GDSC1 3.3316 7.0294 2.0747 21.3445
HCC202 GDSC1 3.4678 7.4828 1.9834 21.3354
CAL-85-1 GDSC1 3.5585 6.6966 2.4508 17.6637
HCC1954 GDSC1 3.5793 5.0997 3.2187 11.8265
Evsa-T GDSC1 3.6087 7.7113 2.0014 20.5924
BT-483 GDSC1 3.6357 9.4961 1.1429 25.5915
HCC2157 GDSC1 3.7191 5.5467 3.1556 11.6414
HCC70 GDSC1 3.7984 5.8981 3.0641 11.9897
BT-20 GDSC1 3.9036 5.6261 3.2952 9.7511
MDA-MB-436 GDSC1 3.9595 5.6648 3.3288 9.2513
ZR-75-30 GDSC1 4.2371 7.0302 2.8965 11.5216
CAL-120 GDSC1 4.2473 9.1308 1.855 18.9534
HCC1419 GDSC1 4.2777 6.6974 3.0971 9.8109
MDA-MB-330 GDSC1 4.3288 6.2394 3.3689 7.4903
HCC2218 GDSC1 4.4528 7.9692 2.6062 12.9411
T-47D GDSC1 4.4613 6.9105 3.1419 8.8048
CAL-51 GDSC1 4.4821 8.3086 2.4605 13.9112
HCC1428 GDSC1 4.5103 8.2376 2.5187 13.3844
MDA-MB-231 GDSC1 4.5494 7.3144 3.0108 9.523
EFM-192A GDSC1 4.6644 6.7808 3.3649 6.3926
UACC-812 GDSC1 4.6646 8.3867 2.5676 12.4908
MDA-MB-415 GDSC1 4.9644 6.9039 3.5192 4.347
YMB-1-E GDSC1 5.5388 8.7913 3.0018 6.7046
HCC1500 GDSC1 6.4206 12.1548 1.986 11.3905
CAL-148 GDSC1 6.5316 7.9522 3.8633 0.2607
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAS-1 GDSC1 1.3079 3.3173 1.2426 38.0422
MOG-G-CCM GDSC1 1.6162 3.1861 1.5845 34.0161
YH-13 GDSC1 1.8798 3.4798 1.8306 30.8353
D-263MG GDSC1 1.9002 3.1322 1.8855 30.3634
42-MG-BA GDSC1 1.9227 3.7163 1.8406 30.5056
D-392MG GDSC1 1.9363 3.8529 1.8298 30.4888
KS-1 [Human Krukenberg tumour] GDSC1 2.0428 4.0798 1.8963 29.4167
D-336MG GDSC1 2.0597 3.8777 1.9587 28.9185
D283 Med GDSC1 2.0821 5.1892 1.5959 30.998
M059J GDSC1 2.212 3.5517 2.1748 26.6098
SF539 GDSC1 2.2399 3.4468 2.2156 26.1788
SNB-75 GDSC1 2.3102 5.1023 1.873 27.9705
GI-1 GDSC1 2.3186 3.829 2.2478 25.4944
SF126 GDSC1 2.3868 3.513 2.3638 24.3346
KALS-1 GDSC1 2.4912 5.1018 2.0675 25.685
GaMG GDSC1 2.6269 4.5374 2.4091 22.6262
D-423MG GDSC1 2.6356 5.3943 2.1081 24.6171
D-502MG GDSC1 2.6771 6.1653 1.8257 26.2275
MOG-G-UVW GDSC1 2.9397 5.0656 2.5608 19.8632
DK-MG GDSC1 3.0622 5.1963 2.6386 18.6689
D-542MG GDSC1 3.1054 5.024 2.7534 17.622
T98G GDSC1 3.1416 3.8986 3.1199 14.8916
SF268 GDSC1 3.1705 5.3107 2.7046 17.6385
Daoy GDSC1 3.2294 4.523 3.0693 14.7251
H4 GDSC1 3.2553 4.361 3.147 14.0464
D-247MG GDSC1 3.3223 5.3072 2.8638 15.7161
YKG-1 GDSC1 3.3876 5.186 2.9834 14.512
SW1088 GDSC1 3.4954 5.0701 3.1448 12.788
U-251MG GDSC1 3.5088 4.7979 3.2709 11.8007
NMC-G1 GDSC1 3.5438 5.4366 3.0325 13.3871
PFSK-1 GDSC1 3.5776 5.1914 3.1767 12.1466
U-118MG GDSC1 3.5795 6.1944 2.7126 15.6303
D-566MG GDSC1 3.6005 5.4994 3.0605 12.9092
Hs 683 GDSC1 3.613 4.5153 3.4879 9.7027
LN-18 GDSC1 3.6231 4.8009 3.3906 10.3446
Becker GDSC1 3.6251 4.9497 3.3307 10.7727
GB-1 GDSC1 3.7133 6.6295 2.6286 15.672
AM-38 GDSC1 3.831 6.3104 2.8939 13.1581
LN-229 GDSC1 3.8369 5.6692 3.2111 10.6904
A-172 GDSC1 3.9525 4.5161 3.853 5.3001
LNZTA3WT4 GDSC1 4.1531 6.1182 3.2795 8.8524
KNS-42 GDSC1 4.2266 5.4471 3.6781 5.4342
LN-405 GDSC1 4.296 7.071 2.9257 11.0773
SW1783 GDSC1 4.3502 6.5044 3.2542 8.3157
DBTRG-05MG GDSC1 4.4347 6.9652 3.0931 9.2781
KNS-81-FD GDSC1 4.5133 7.063 3.1074 8.8955
8-MG-BA GDSC1 4.5359 7.3541 2.9803 9.8045
U-87MG ATCC GDSC1 4.5773 7.3247 3.0277 9.2977
SK-MG-1 GDSC1 4.6152 6.3397 3.5458 5.1373
ONS-76 GDSC1 4.6659 6.5873 3.4616 5.6363
Onda 11 GDSC1 4.7453 7.348 3.1456 7.8407
Onda 10 GDSC1 4.7547 6.7358 3.4539 5.4279
KINGS-1 GDSC1 4.7789 8.1173 2.7903 10.4497
SF295 GDSC1 4.8199 6.0652 3.8222 2.4605
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 1.912 4.0248 1.7667 31.0309
TGBC24TKB GDSC1 3.6596 5.0911 3.3048 10.7945
TGBC1TKB GDSC1 4.4008 6.5427 3.2765 7.9603
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1 -0.2862 2.6631 -0.3702 56.8453
MFE-280 GDSC1 0.9915 3.6175 0.8526 42.2264
RL95-2 GDSC1 1.6986 5.6043 1.0293 36.3126
MFE-319 GDSC1 2.548 7.2683 1.1967 30.4858
EN GDSC1 2.6045 6.4593 1.6213 27.8602
KLE GDSC1 3.1127 7.9897 1.4035 26.5338
ESS-1 GDSC1 3.3164 4.2765 3.2367 13.09
MFE-296 GDSC1 3.7293 8.4502 1.7453 21.733
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-54 GDSC1 0.3859 1.8896 0.3816 49.2044
769-P GDSC1 1.0953 3.4185 0.9998 40.7992
KTCTL-21 GDSC1 1.1113 4.4849 0.7723 41.5387
KTCTL-140 GDSC1 1.3033 2.9825 1.2744 37.9016
NCC021 GDSC1 1.4183 4.52 1.0969 37.9475
KTCTL-26A GDSC1 1.4322 3.5576 1.3393 36.655
KTCTL-13 GDSC1 1.4979 4.2774 1.252 36.6494
UO-31 GDSC1 1.664 4.1154 1.475 34.3397
KTCTL-195 GDSC1 1.8575 4.4784 1.5881 32.4404
LB2241-RCC GDSC1 1.9785 5.0733 1.526 32.0327
TK-10 GDSC1 1.996 3.5032 1.9513 29.356
VMRC-RCZ GDSC1 2.062 4.4923 1.8071 29.8567
ACHN GDSC1 2.3114 7.3496 0.923 33.0737
Caki-1 GDSC1 2.4188 5.1115 1.9863 26.624
LB996-RCC GDSC1 2.472 4.3537 2.2943 24.284
SN12C GDSC1 2.4938 5.3873 1.9607 26.3676
KMRC-1 GDSC1 2.5522 3.6671 2.5221 22.3125
BB65-RCC GDSC1 2.622 4.5941 2.3858 22.8123
HA7-RCC GDSC1 2.6704 4.4805 2.4739 21.9408
SW13 GDSC1 2.8725 5.8667 2.1572 23.0302
RXF 393L GDSC1 2.9157 7.5711 1.4156 27.426
786-O GDSC1 2.9283 5.7986 2.2442 22.146
LB1047-RCC GDSC1 2.9899 3.9961 2.9425 16.9544
SW156 GDSC1 3.3511 7.4357 1.8969 22.4343
BFTC-909 GDSC1 3.3563 4.8139 3.1023 13.809
OS-RC-2 GDSC1 3.9635 6.4047 2.9686 12.0318
VMRC-RCW GDSC1 4.3793 7.9013 2.5798 13.4021
RCC10RGB GDSC1 4.6641 10.6822 1.4222 20.0691
A-704 GDSC1 4.7845 10.3886 1.665 18.204
KMRC-20 GDSC1 4.8037 6.2601 3.719 3.2674
KTCTL-1M GDSC1 4.8147 7.7551 2.9967 8.7676
A-498 GDSC1 5.8608 7.4892 3.7632 1.0942
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CCK-81 GDSC1 0.827 2.7741 0.7934 43.8302
LoVo GDSC1 1.7181 6.0325 0.8817 36.804
CaR-1 GDSC1 2.6083 4.9481 2.2499 23.8117
RKO GDSC1 2.7882 5.4558 2.2441 22.8768
LS180 GDSC1 2.8477 5.2765 2.3797 21.6223
SNU-175 GDSC1 2.8777 4.4761 2.7011 19.2223
HT115 GDSC1 2.9359 3.6968 2.9235 17.4037
HT-55 GDSC1 3.1531 4.7402 2.9119 16.2422
SNU-1040 GDSC1 3.2032 7.9969 1.4853 25.6425
LS513 GDSC1 3.4609 6.6718 2.37 18.6871
SW837 GDSC1 3.6711 7.4472 2.1886 19.0441
HCT 116 GDSC1 3.7749 5.42 3.2698 10.5168
NCI-H716 GDSC1 3.8375 9.6018 1.2681 24.0802
COLO205 GDSC1 3.8377 4.3768 3.7775 6.4524
GP5d GDSC1 3.8996 6.033 3.0932 11.3322
SNU-C2B GDSC1 4.2291 7.9351 2.4374 15.0086
SW1417 GDSC1 4.2625 14.0134 -0.5734 30.2529
C2BBe1 GDSC1 4.3277 12.1858 0.3948 26.4219
NCI-H747 GDSC1 4.464 8.7627 2.2188 15.7011
RCM-1 [Human ESC] GDSC1 4.6903 7.8726 2.8435 10.3362
SW48 GDSC1 4.7117 7.8805 2.8561 10.1699
SNU-81 GDSC1 4.789 7.6176 3.0453 8.4755
HT-29 GDSC1 4.8681 6.3899 3.7 3.2439
KM12 GDSC1 4.9106 8.4554 2.7229 10.535
SW1463 GDSC1 4.9191 7.2234 3.3337 5.8753
SW620 GDSC1 5.0031 6.9932 3.5024 4.372
MDST8 GDSC1 5.0189 7.1764 3.4255 4.9069
HCT 15 GDSC1 5.0226 8.7248 2.6737 10.5513
SNU-407 GDSC1 5.0562 9.8478 2.1445 14.198
LS411N GDSC1 5.0811 9.6001 2.2857 13.1495
LS123 GDSC1 5.2216 8.3125 3.0176 7.418
COLO 678 GDSC1 5.267 7.709 3.3364 4.938
CW-2 GDSC1 5.2833 8.6173 2.913 8.0231
LS1034 GDSC1 5.3113 7.8138 3.3156 4.982
SW1116 GDSC1 5.332 9.978 2.2851 12.3845
SNU-C5 GDSC1 5.3841 9.7103 2.4534 11.0601
SNU-61 GDSC1 5.4368 8.9771 2.8451 8.1047
SW626 GDSC1 5.4428 8.315 3.1644 5.7632
COLO 320HSR GDSC1 5.6915 8.8218 3.0852 5.7418
CL-11 GDSC1 5.7402 7.6366 3.6441 1.9066
T84 GDSC1 5.8456 11.5646 1.8784 13.5754
HCC2998 GDSC1 5.8538 10.537 2.3797 10.2748
SW948 GDSC1 6.2246 7.6619 3.8509 0.4343
SNU-C1 GDSC1 6.7489 8.2495 3.8389 0.2408
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 4.48 7.1692 3.0278 9.6286
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-1 GDSC1 0.1728 3.3424 0.0188 51.6444
SNU-423 GDSC1 1.2219 3.0705 1.1807 38.9801
SNU-449 GDSC1 1.5376 4.4654 1.243 36.4177
JHH-4 GDSC1 1.552 2.6878 1.5472 34.6539
JHH-2 GDSC1 1.6924 4.3838 1.4351 34.3719
HLE GDSC1 1.7106 4.1039 1.5286 33.7302
SNU-475 GDSC1 1.7786 3.37 1.7366 32.0529
Hep 3B2.1-7 GDSC1 2.0218 4.038 1.8832 29.6277
Huh-7 GDSC1 2.356 5.2374 1.8717 27.715
SNU-398 GDSC1 3.1768 5.3777 2.6828 17.7655
JHH-7 GDSC1 3.347 4.8758 3.0683 14.1016
JHH-6 GDSC1 4.3704 6.2871 3.3794 7.2583
SNU-387 GDSC1 4.4495 8.1051 2.5356 13.4764
SK-HEP-1 GDSC1 4.8961 6.3788 3.7236 2.9992
Hep-G2/C3A GDSC1 5.2269 7.4279 3.4428 4.2576
HuH-1 GDSC1 6.0339 7.7543 3.7364 1.0417
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 172 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1341 GDSC1 -0.6777 2.6055 -0.7794 60.7889
NCI-H510A GDSC1 0.8514 3.2833 0.7591 43.7413
HCC827 GDSC1 0.9662 7.2363 -0.4053 45.1418
LC-2/ad GDSC1 1.2942 3.6307 1.1775 38.4731
Calu-3 GDSC1 1.2984 5.5653 0.6153 40.6341
NCI-H3255 GDSC1 1.3261 4.3269 1.0512 38.8204
NCI-H1581 GDSC1 1.4594 7.3979 0.0356 41.1335
IST-SL2 GDSC1 1.542 6.9716 0.3056 39.9068
HCC78 GDSC1 1.5543 3.6516 1.4547 35.1845
SBC-3 GDSC1 1.5649 4.213 1.3421 35.7262
EPLC-272H GDSC1 1.9075 3.5578 1.8495 30.5439
NCI-H322M GDSC1 1.9705 6.5064 0.9489 34.9393
NCI-H1048 GDSC1 2.0013 3.7269 1.9235 29.4994
PaCa-3 GDSC1 2.0517 7.54 0.5752 35.9495
NCI-H2066 GDSC1 2.0539 7.6384 0.5328 36.0912
NCI-H2810 GDSC1 2.0588 3.2883 2.0395 28.4101
COR-L105 GDSC1 2.1064 5.3749 1.5526 31.0983
Calu-6 GDSC1 2.1499 6.9794 0.9268 33.972
NCI-H522 GDSC1 2.271 4.0244 2.1573 26.3669
NCI-H2795 GDSC1 2.3287 3.8745 2.2505 25.4161
NCI-H1648 GDSC1 2.3552 4.8641 2.0064 26.8582
PC-14 GDSC1 2.4404 4.2695 2.2827 24.5447
UMC-11 GDSC1 2.4422 5.6537 1.7991 27.6793
NCI-H1304 GDSC1 2.5139 10.866 -0.5567 37.0567
IST-SL1 GDSC1 2.5512 7.0973 1.2786 30.0489
NCI-H1155 GDSC1 2.5624 4.5745 2.3272 23.5459
NCI-H661 GDSC1 2.5785 7.5935 1.0757 30.9213
NCI-H64 GDSC1 2.5839 5.1327 2.1553 24.585
NCI-H1869 GDSC1 2.6056 6.7775 1.4791 28.672
NCI-H358 GDSC1 2.6108 5.7166 1.9499 25.7927
NCI-H290 GDSC1 2.6258 7.5954 1.1213 30.4504
NCI-H2444 GDSC1 2.638 6.9116 1.4504 28.6598
NCI-H524 GDSC1 2.6768 4.2768 2.5387 21.4663
NCI-H226 GDSC1 2.7908 4.5538 2.5823 20.5237
EKVX GDSC1 2.8047 6.3581 1.8697 25.2783
NCI-H69 GDSC1 2.8134 5.1645 2.3879 21.7474
NCI-H2291 GDSC1 2.8232 7.3568 1.427 27.8277
EMC-BAC-2 GDSC1 2.8474 6.0713 2.0413 23.9395
NCI-H1734 GDSC1 2.85 7.9742 1.1601 29.112
LK-2 GDSC1 2.9472 4.9819 2.6011 19.5395
NCI-H847 GDSC1 2.9641 7.1353 1.6691 25.7143
NCI-H1770 GDSC1 2.9924 3.8299 2.9698 16.7622
NCI-H1876 GDSC1 3.0063 6.2168 2.1371 22.4868
A-427 GDSC1 3.015 6.551 1.9924 23.4144
NCI-H647 GDSC1 3.0318 5.0597 2.6612 18.666
CAL-12T GDSC1 3.05 5.5677 2.4699 19.9387
NCI-H2731 GDSC1 3.0639 4.9375 2.7427 17.9172
ABC-1 GDSC1 3.1186 6.2702 2.2252 21.3251
NCI-H1781 GDSC1 3.1195 5.8898 2.3992 20.0953
NCI-H2347 GDSC1 3.1372 6.1573 2.2956 20.7415
LXF 289 GDSC1 3.1585 4.186 3.0867 15.0088
NCI-H520 GDSC1 3.1588 7.0263 1.91 23.2524
NCI-H1792 GDSC1 3.2217 4.5977 3.036 14.9987
SBC-5 GDSC1 3.2279 4.2658 3.1429 14.2303
DMS 114 GDSC1 3.2483 6.0144 2.4722 18.9429
NCI-H211 GDSC1 3.2653 5.7296 2.6189 17.7933
HOP-62 GDSC1 3.2728 4.9299 2.9682 15.2079
NCI-H441 GDSC1 3.3423 5.7408 2.6915 16.8882
NCI-H513 GDSC1 3.3579 7.0959 2.0677 21.2699
NCI-H1650 GDSC1 3.4006 5.5601 2.8321 15.5671
Lu-135 GDSC1 3.5047 8.114 1.7081 22.9372
LCLC-97TM1 GDSC1 3.5241 5.5601 2.9564 14.0514
NCI-H1703 GDSC1 3.533 6.5501 2.4974 17.4367
NCI-H720 GDSC1 3.5446 4.7019 3.3463 11.0725
LCLC-103H GDSC1 3.562 5.2969 3.1138 12.6916
NCI-H596 GDSC1 3.5632 9.6005 1.0265 26.4969
NCI-H2869 GDSC1 3.5656 6.3402 2.6294 16.3154
NCI-H1563 GDSC1 3.5698 5.9937 2.7989 15.0258
EMC-BAC-1 GDSC1 3.6034 7.9627 1.8729 21.4609
NCI-H1623 GDSC1 3.6185 12.4245 -0.3295 31.795
NCI-H2369 GDSC1 3.6215 4.8162 3.3827 10.4106
NCI-H1755 GDSC1 3.6306 4.5651 3.4894 9.597
Lu-99A GDSC1 3.6477 4.9773 3.3423 10.5753
NCI-H2030 GDSC1 3.6713 6.3282 2.7358 15.0491
NCI-H1975 GDSC1 3.6822 5.2837 3.2411 11.1636
NCI-H1838 GDSC1 3.6962 9.8756 1.0078 26.0294
LB647-SCLC GDSC1 3.7199 11.6533 0.1432 29.7324
NCI-H650 GDSC1 3.731 7.9132 2.0128 19.99
NCI-H1915 GDSC1 3.7348 5.5665 3.1616 11.5239
NCI-H1944 GDSC1 3.7959 9.3909 1.3368 23.8724
HARA [Human squamous cell lung carcinoma] GDSC1 3.7961 6.1416 2.9438 12.9239
NCI-H2818 GDSC1 3.8026 5.6041 3.2094 10.854
NCI-H2722 GDSC1 3.8114 5.5208 3.2576 10.4456
NCI-H2804 GDSC1 3.843 5.6356 3.2331 10.4942
NCI-H1568 GDSC1 3.8627 13.0703 -0.4406 31.2401
NCI-H2591 GDSC1 3.9174 5.8546 3.197 10.4524
NCI-H2595 GDSC1 3.9433 5.4473 3.4192 8.6208
DMS 53 GDSC1 3.9794 7.4069 2.4854 15.6306
NCI-H446 GDSC1 3.9852 7.5111 2.4387 15.9501
NCI-H23 GDSC1 4.0035 5.2533 3.5701 7.1932
NCI-H1666 GDSC1 4.0472 8.2358 2.1316 17.8852
SBC-1 GDSC1 4.0622 6.3901 3.0642 10.893
NCI-H2228 GDSC1 4.0717 5.7803 3.375 8.4257
NCI-H810 GDSC1 4.1164 8.0482 2.2849 16.5404
NCI-H1435 GDSC1 4.1345 10.155 1.2478 23.0082
NCI-H1836 GDSC1 4.1831 7.4006 2.6655 13.4902
NCI-H1573 GDSC1 4.2297 6.5081 3.1511 9.5669
DMS 273 GDSC1 4.25 7.4184 2.7133 12.8754
Ms-1 GDSC1 4.2534 6.9013 2.9747 10.8548
NCI-H2405 GDSC1 4.3113 7.8347 2.5567 13.8235
LOU-NH91 GDSC1 4.3284 8.0046 2.486 14.2821
NCI-H460 GDSC1 4.3364 5.3874 3.8012 4.0544
NCI-H1105 GDSC1 4.3389 7.9153 2.5394 13.8495
NCI-H2171 GDSC1 4.3455 6.2362 3.3844 7.3082
SW1573 GDSC1 4.3737 7.3742 2.8387 11.4648
NCI-H2087 GDSC1 4.3787 6.5881 3.2358 8.3579
COR-L303 GDSC1 4.5116 9.9308 1.674 19.1124
NCI-H2342 GDSC1 4.5182 7.8411 2.7231 11.8329
EBC-1 GDSC1 4.5716 7.4655 2.9531 9.8937
NCI-H1355 GDSC1 4.5848 6.7709 3.3091 7.0823
NCI-H2081 GDSC1 4.5927 6.5063 3.4464 5.9835
RERF-LC-KJ GDSC1 4.644 5.7723 3.8445 2.7469
NCI-H2141 GDSC1 4.6713 7.0032 3.2602 7.1856
IA-LM GDSC1 4.6877 7.5523 3.0005 9.1429
NCI-H2803 GDSC1 4.7256 6.8249 3.3888 6.0184
NCI-H2029 GDSC1 4.7269 8.546 2.5372 12.5037
NCI-H1694 GDSC1 4.7728 7.8467 2.9197 9.4879
NCI-H187 GDSC1 4.7815 8.167 2.7677 10.6119
NCI-H146 GDSC1 4.7961 9.8475 1.9437 16.3962
NCI-H1993 GDSC1 4.8015 7.3369 3.1931 7.3002
NCI-H3122 GDSC1 4.8095 6.8145 3.4549 5.2606
NCI-H2461 GDSC1 4.8418 7.0835 3.3468 5.9968
Lu-65 GDSC1 4.8458 6.8552 3.4609 5.1112
NCI-H82 GDSC1 4.8603 9.1029 2.3639 13.311
COR-L321 GDSC1 4.8854 6.5819 3.62 3.7966
RERF-LC-MS GDSC1 4.886 6.6594 3.5833 4.0713
NCI-H2009 GDSC1 4.8987 8.3302 2.7758 10.1776
NCI-H2135 GDSC1 4.9211 8.7405 2.59 11.483
NCI-H1688 GDSC1 4.9379 8.7117 2.6168 11.2333
SK-LU-1 GDSC1 4.9639 8.2906 2.8438 9.4658
SHP-77 GDSC1 4.9686 7.7767 3.0993 7.519
NCI-H2196 GDSC1 4.9701 14.5893 -0.2821 26.9219
NCI-H1437 GDSC1 4.9962 6.5423 3.7107 2.8555
BEN GDSC1 5.0201 7.5452 3.2485 6.2394
NCI-H292 GDSC1 5.0759 7.8272 3.1509 6.8213
NCI-H1651 GDSC1 5.083 8.4882 2.834 9.1815
COR-L311 GDSC1 5.101 6.9437 3.5895 3.4894
Lu-139 GDSC1 5.1339 7.0984 3.538 3.7859
HCC33 GDSC1 5.1452 7.7928 3.2154 6.1475
NCI-H2373 GDSC1 5.1874 8.3255 2.9875 7.7368
CPC-N GDSC1 5.1989 7.4398 3.4192 4.497
SK-MES-1 GDSC1 5.2074 7.1275 3.5704 3.3831
NCI-H526 GDSC1 5.213 7.6915 3.3094 5.2713
HCC15 GDSC1 5.2589 8.1242 3.1336 6.4557
RERF-LC-Sq1 GDSC1 5.2905 12.0457 1.2346 19.0346
COR-L23 GDSC1 5.3435 8.0955 3.2035 5.7228
NCI-H727 GDSC1 5.3967 9.7198 2.4578 10.9928
SW1271 GDSC1 5.4916 12.0669 1.3757 17.6211
NCI-H345 GDSC1 5.4948 6.6112 3.9451 0.602
NCI-H1436 GDSC1 5.5247 12.564 1.1552 18.7395
NCI-H841 GDSC1 5.545 10.5766 2.146 12.7007
HCC44 GDSC1 5.6019 8.4021 3.2243 4.9607
NCI-H2023 GDSC1 5.6359 7.4231 3.681 1.8436
NCI-H196 GDSC1 5.6828 8.8548 3.0643 5.9095
NCI-H2170 GDSC1 5.7222 9.2075 2.9243 6.8107
NCI-H1092 GDSC1 5.7692 11.8437 1.6883 14.9634
NCI-H2122 GDSC1 5.8239 7.4487 3.7624 1.1394
KNS-62 GDSC1 5.8246 10.2264 2.5086 9.4703
COLO 668 GDSC1 5.9479 11.7163 1.8765 13.3051
NCI-H838 GDSC1 6.0995 7.4584 3.876 0.4246
Lu-165 GDSC1 6.124 13.8413 0.9677 17.9832
Lu-134-A GDSC1 6.1324 13.6278 1.0779 17.3872
ChaGo-K-1 GDSC1 6.1859 9.8875 2.8964 5.9567
COR-L88 GDSC1 6.4039 16.5395 -0.1506 22.2689
NCI-H209 GDSC1 6.4994 8.6963 3.5738 1.3406
NCI-H1793 GDSC1 6.5719 18.3275 -0.9057 24.5761
NCI-H1299 GDSC1 6.7292 8.4242 3.7704 0.4163
NCI-H2110 GDSC1 6.8682 9.7224 3.3331 2.1347
A-549 GDSC1 6.9955 8.7971 3.738 0.3858
COR-L95 GDSC1 7.4891 18.7541 -0.4555 20.7608
NCI-H835 GDSC1 7.7837 18.7383 -0.2452 19.2835
NCI-H2172 GDSC1 11.1879 23.3108 -0.2449 12.9501
⏷ Show the Full List of 172 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 5.5053 7.5935 3.5353 3.0051
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 GDSC1 0.0516 3.6344 -0.1703 52.8421
TE-8 GDSC1 0.5423 5.3981 -0.1399 48.0207
OE19 GDSC1 1.5149 4.5752 1.1858 36.8522
KYSE-140 GDSC1 1.5285 4.535 1.2127 36.6288
KYSE-270 GDSC1 1.5316 4.3187 1.2777 36.2866
KYSE-150 GDSC1 1.5477 3.904 1.3973 35.5483
TE-6 GDSC1 1.677 5.855 0.909 36.9621
TE-15 GDSC1 1.6961 6.8565 0.5145 38.2907
TE-10 GDSC1 1.699 3.9603 1.5495 33.6859
TE-5 GDSC1 1.9853 3.3153 1.9603 29.3646
COLO 680N GDSC1 2.0211 4.7809 1.6722 30.9246
TE-9 GDSC1 2.4519 3.9524 2.3689 23.9089
KYSE-520 GDSC1 2.7362 4.9758 2.3772 22.2382
EC-GI-10 GDSC1 3.0753 4.9413 2.7535 17.78
TE-11 GDSC1 3.1052 4.429 2.9633 16.1478
TE-4 GDSC1 3.2106 5.1142 2.8284 16.538
OE33 GDSC1 3.4817 5.7644 2.8199 15.2742
KYSE-70 GDSC1 3.5238 6.0592 2.7232 15.8034
OE21 GDSC1 3.639 6.7676 2.4919 17.0088
KYSE-410 GDSC1 3.8879 6.0546 3.0718 11.547
T.T GDSC1 3.9394 5.716 3.2851 9.676
KYSE-180 GDSC1 4.4191 8.0894 2.5185 13.7115
KYSE-510 GDSC1 4.4774 8.9317 2.1453 16.1622
TE-1 GDSC1 4.6432 6.4424 3.5161 5.2821
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHOS-4 GDSC1 0.8471 3.8096 0.6563 44.0924
TOV-112D GDSC1 1.2374 3.4417 1.1488 39.0295
JHOS-2 GDSC1 1.9305 4.0612 1.7784 30.8436
OVISE GDSC1 1.9335 5.9203 1.1544 34.2367
FU-OV-1 GDSC1 1.9358 7.4235 0.5107 36.8521
RMG-I GDSC1 2.0757 6.4134 1.0979 33.6352
DOV13 GDSC1 2.1206 4.8432 1.7594 29.7948
A2780 GDSC1 2.1953 4.6365 1.9081 28.4239
SK-OV-3 GDSC1 2.2316 5.1808 1.7596 29.133
Caov-3 GDSC1 2.3522 4.5113 2.1177 26.1479
Kuramochi GDSC1 2.642 8.1872 0.8578 31.6032
OC 314 GDSC1 2.7253 4.3331 2.5765 20.9338
OAW28 GDSC1 2.9477 6.5794 1.9123 24.2747
OVCAR-3 GDSC1 3.1423 6.802 2.0003 22.7389
TOV-21G GDSC1 3.1916 4.743 2.9523 15.7501
OV-90 GDSC1 3.3204 6.4079 2.3601 19.407
EFO-27 GDSC1 3.6974 9.1589 1.3652 24.1251
OAW42 GDSC1 3.7086 6.5723 2.6521 15.5163
TYK-nu GDSC1 3.8107 5.1569 3.4278 9.1512
OVCAR-5 GDSC1 3.9276 9.4509 1.4218 22.8525
OVCAR-4 GDSC1 3.9571 7.0532 2.6415 14.5578
OVCAR-8 GDSC1 3.976 5.4894 3.4297 8.398
IGROV-1 GDSC1 4.2858 7.2579 2.8237 11.9004
OVTOKO GDSC1 4.4022 8.1899 2.4544 14.2425
Caov-4 GDSC1 4.5889 8.7783 2.3121 14.5998
EFO-21 GDSC1 5.0389 8.4589 2.8163 9.4451
OVK18 GDSC1 5.2753 7.725 3.3342 4.9338
ES-2 GDSC1 5.3886 7.6552 3.4381 3.921
OVKATE GDSC1 6.0798 7.5734 3.8256 0.617
OV56 GDSC1 6.1672 7.7259 3.8044 0.6346
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Capan-2 GDSC1 1.7227 4.5235 1.4278 34.2114
MZ-PC-1 GDSC1 2.0669 4.8085 1.7127 30.4029
Panc 03.27 GDSC1 2.476 4.3791 2.2915 24.2792
Panc 04.03 GDSC1 3.0338 5.3163 2.5595 19.3813
Panc 02.03 GDSC1 3.1512 8.4489 1.2167 27.3632
HuP-T4 GDSC1 3.2758 5.2922 2.822 16.2543
Panc 08.13 GDSC1 3.5955 8.4495 1.6253 23.0454
KP-3 GDSC1 3.6958 6.2883 2.7782 14.6213
CFPAC-1 GDSC1 3.7339 5.4241 3.2276 11.0255
SU.86.86 GDSC1 3.7669 5.9804 2.9944 12.6617
HuP-T3 GDSC1 3.8579 7.5353 2.3138 17.3713
SUIT-2 GDSC1 4.0372 6.0482 3.2113 9.8452
Capan-1 GDSC1 4.2539 6.1575 3.3468 7.9392
KP-4 GDSC1 4.2615 6.3469 3.2586 8.6045
MIA PaCa-2 GDSC1 4.2814 5.4579 3.7198 4.8975
PaTu 8988t GDSC1 4.3474 7.4922 2.758 12.1771
PL4 GDSC1 4.5632 7.5471 2.9058 10.2857
KP-1N GDSC1 4.6981 7.1813 3.1923 7.6275
HPAC GDSC1 4.7351 6.5781 3.5169 4.9993
PaTu 8902 GDSC1 4.7962 6.9306 3.3886 5.8085
HPAF-II GDSC1 4.9079 9.5336 2.1869 14.3905
BxPC-3 GDSC1 5.0824 7.8915 3.1244 7.0035
QGP-1 GDSC1 5.0896 8.8866 2.6435 10.5688
SW1990 GDSC1 5.2213 8.5252 2.9145 8.1847
YAPC GDSC1 5.2483 8.8378 2.7817 9.0887
Panc 10.05 GDSC1 5.2535 10.4084 2.0158 14.4352
PSN1 GDSC1 5.5665 7.7815 3.4862 3.2172
DAN-G GDSC1 5.7465 7.859 3.5521 2.46
Hs 766T GDSC1 6.0261 7.8248 3.705 1.2024
AsPC-1 GDSC1 6.8634 8.888 3.6544 0.7081
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 1.9175 3.8672 1.8066 30.7497
MPP 89 GDSC1 2.3146 4.0485 2.1994 25.8325
MSTO-211H GDSC1 3.3726 6.6739 2.2844 19.7024
NCI-H28 GDSC1 3.3859 6.6717 2.2982 19.5429
NCI-H2052 GDSC1 3.9056 6.3094 2.963 12.3134
NCI-H2452 GDSC1 4.4113 6.8397 3.1367 9.0195
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PC-3 GDSC1 3.6127 7.35 2.1827 19.3381
VCaP GDSC1 4.1908 5.269 3.7351 5.1258
22Rv1 GDSC1 4.3518 7.0823 2.9666 10.5573
LNCaP clone FGC GDSC1 4.4369 7.7945 2.6805 12.441
DU145 GDSC1 4.443 7.6039 2.7807 11.6604
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 3.7037 6.3672 2.7473 14.8205
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 940.T GDSC1 0.4011 2.5143 0.369 49.0405
LOX-IMVI GDSC1 1.0409 2.217 1.0386 41.0258
CHL-1 GDSC1 1.1129 4.6476 0.7258 41.6795
RPMI-7951 GDSC1 1.22 3.0264 1.1831 38.9811
A-431 GDSC1 1.3882 2.806 1.3747 36.7534
IGR-1 GDSC1 1.6902 4.1109 1.5046 34.0004
WM1552C GDSC1 1.7249 3.6923 1.6315 33.0351
WM793 GDSC1 1.8588 4.0714 1.6979 31.7834
WM35 GDSC1 1.8676 4.796 1.5005 32.873
VMRC-MELG GDSC1 1.9109 4.0423 1.7614 31.07
A-375 GDSC1 1.9588 5.8085 1.2261 33.7332
SK-MEL-28 GDSC1 2.097 5.4359 1.5193 31.3433
WM115 GDSC1 2.3377 7.5128 0.8744 33.1421
COLO 800 GDSC1 2.4287 3.9028 2.3533 24.1486
WM278 GDSC1 2.4978 5.2283 2.0268 25.9153
SK-MEL-24 GDSC1 2.5197 7.2985 1.1545 30.8484
MMAc-SF GDSC1 2.795 5.5669 2.2051 23.1076
DJM-1 GDSC1 2.7986 5.8753 2.0773 23.9534
IST-MEL1 GDSC1 2.8141 5.4712 2.2649 22.5962
Hs 938.T GDSC1 2.9019 6.8455 1.7437 25.5707
IGR-37 GDSC1 3.0437 6.1073 2.2244 21.6997
A-388 GDSC1 3.053 5.3785 2.5536 19.3249
A101D GDSC1 3.0808 5.3464 2.596 18.8785
A2058 GDSC1 3.1221 5.3423 2.6409 18.3446
G-mel GDSC1 3.2598 5.9367 2.5193 18.5459
SK-MEL-5 GDSC1 3.3471 6.4467 2.3678 19.2269
IPC-298 GDSC1 3.371 5.5311 2.8151 15.8365
Mel Ho GDSC1 3.4528 6.578 2.4074 18.4548
HT-144 GDSC1 3.457 5.8279 2.7659 15.7927
SK-MEL-30 GDSC1 3.4724 6.6956 2.3696 18.6382
SK-MEL-2 GDSC1 3.4915 5.0543 3.1473 12.7888
COLO 792 GDSC1 3.5559 5.423 3.0508 13.1926
Mel JuSo GDSC1 3.7379 6.1192 2.8999 13.5117
COLO 783 GDSC1 3.9009 5.8209 3.198 10.5146
COLO 679 GDSC1 3.9438 5.8343 3.2313 10.0747
RVH-421 GDSC1 4.0258 10.1587 1.1533 23.9424
M14 GDSC1 4.0875 8.2878 2.1404 17.6656
SK-MEL-3 GDSC1 4.1501 6.7388 2.9675 11.3023
MZ-MEL-2 GDSC1 4.1578 8.2519 2.2186 16.8473
SH-4 GDSC1 4.2186 6.138 3.3264 8.2328
451Lu GDSC1 4.2901 6.9947 2.9589 10.842
LB373-MEL-D GDSC1 4.4303 6.3617 3.3909 6.9584
SK-MEL-1 GDSC1 4.4309 6.4401 3.3522 7.2609
MZ-MEL-7 GDSC1 4.7367 7.4526 3.0874 8.3169
LB2518-MEL GDSC1 4.7464 6.9688 3.3334 6.3838
G-361 GDSC1 4.7973 6.588 3.5565 4.517
GAK GDSC1 4.8573 7.4762 3.1657 7.3419
CP66-MEL GDSC1 4.8791 7.7647 3.0399 8.239
UACC-62 GDSC1 4.8917 6.4201 3.7012 3.1752
MeWo GDSC1 5.1043 7.8999 3.1356 6.8578
CP50-MEL-B GDSC1 5.2141 8.1778 3.0773 6.9932
COLO 829 GDSC1 5.2822 10.0128 2.2318 12.8998
HMV-II GDSC1 5.4452 8.4034 3.1242 6.0491
WT2-iPS GDSC1 5.6632 8.7693 3.0919 5.7593
UACC-257 GDSC1 6.087 7.6213 3.8106 0.6705
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 1.852 4.704 1.5132 32.9019
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW982 GDSC1 0.3877 2.2183 0.373 49.1914
G-402 GDSC1 1.5013 4.4704 1.2019 36.8703
GCT GDSC1 1.5333 3.975 1.3658 35.8169
Rh41 GDSC1 1.8633 4.9545 1.4428 33.2172
G-401 GDSC1 1.8642 3.9149 1.7389 31.4997
Hs 633.T GDSC1 2.0525 4.2068 1.8756 29.4878
EW-8 GDSC1 2.1532 3.1166 2.147 27.1478
Rh30 GDSC1 2.3571 4.7262 2.0551 26.5296
SW872 GDSC1 2.4472 3.5854 2.4202 23.6053
A-204 GDSC1 2.7571 5.8028 2.0657 24.2487
SK-UT-1 GDSC1 3.0192 5.9695 2.2616 21.5639
Rh18 GDSC1 3.1444 5.6078 2.5497 18.8909
KYM-1 GDSC1 3.1849 5.4934 2.6413 18.0256
RD GDSC1 3.5046 5.5222 2.9541 14.1609
SK-LMS-1 GDSC1 3.6543 6.1229 2.8186 14.4978
SW684 GDSC1 3.8412 7.5443 2.2945 17.5784
VA-ES-BJ GDSC1 4.3332 5.9973 3.4937 6.4911
MES-SA GDSC1 4.5938 6.2075 3.595 4.8203
HT-1080 GDSC1 4.7935 6.0871 3.7946 2.7289
MFH-ino GDSC1 5.2242 8.0761 3.1331 6.5509
RKN GDSC1 6.5496 7.5712 3.9977 0.0481
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-39 GDSC1 -1.3519 1.8741 -1.4122 67.8801
RERF-GC-1B GDSC1 -0.8207 2.7672 -0.955 61.8688
KATO III GDSC1 0.1371 3.9996 -0.1613 51.8789
MKN1 GDSC1 0.9556 5.4607 0.2845 44.0711
NUGC-4 GDSC1 1.2144 8.0119 -0.4857 43.6783
AGS GDSC1 1.8434 4.4861 1.5704 32.6326
GCIY GDSC1 2.0788 6.204 1.1899 33.1772
MKN7 GDSC1 2.5201 5.6147 1.897 26.6301
23132/87 GDSC1 2.6777 6.0597 1.8726 25.9283
IM95 GDSC1 2.8069 5.0363 2.4304 21.4865
TGBC11TKB GDSC1 2.9302 6.3189 2.0142 23.6959
Fu97 GDSC1 3.0603 6.2321 2.1843 21.8945
SNU-1 GDSC1 3.3851 6.1044 2.5661 17.6098
ECC10 GDSC1 3.6452 7.0297 2.3696 17.8717
HGC-27 GDSC1 3.8385 7.7696 2.1803 18.394
NUGC-3 GDSC1 3.9131 6.6373 2.808 13.4738
SCH GDSC1 4.2291 15.0328 -1.111 31.966
Hs 746.T GDSC1 4.3493 7.242 2.8846 11.1995
MKN28 GDSC1 4.6902 8.014 2.7731 10.87
NCI-N87 GDSC1 5.0971 9.9097 2.1448 14.0652
RF-48 GDSC1 5.0979 7.9992 3.0829 7.2723
MKN45 GDSC1 5.3263 10.7806 1.8866 15.0476
OCUM-1 GDSC1 5.8522 9.5158 2.8626 6.9357
SNU-16 GDSC1 5.966 7.2999 3.8812 0.4898
SNU-5 GDSC1 6.5217 8.0195 3.836 0.3316
SNG-M GDSC1 -0.0296 3.1022 -0.1582 53.8892
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 0.5384 2.5869 0.5067 47.3677
B-CPAP GDSC1 1.2078 2.8789 1.1829 39.068
HTC-C3 GDSC1 1.357 4.8728 0.9206 39.1321
8505C GDSC1 1.6501 4.0852 1.4671 34.476
IHH-4 GDSC1 1.6666 3.5932 1.5856 33.685
8305C GDSC1 2.0479 4.7339 1.7166 30.4955
CAL-62 GDSC1 2.1187 4.2833 1.9279 28.756
ML-1 [Human leukemia] GDSC1 2.1296 6.1045 1.2846 32.4022
KMH-2 GDSC1 2.3751 5.9835 1.5918 29.3007
WRO GDSC1 2.6672 5.3791 2.1477 24.1796
K5 GDSC1 2.7592 5.6513 2.1323 23.7915
TT2609-C02 GDSC1 2.8863 5.9772 2.1228 23.1925
BHT-101 GDSC1 3.5885 6.2591 2.6902 15.7581
TT GDSC1 5.0392 8.6901 2.703 10.2844
ASH-3 GDSC1 5.1907 8.5606 2.8757 8.5584
FTC-133 GDSC1 6.2682 7.5591 3.9041 0.2627
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB30-HNC GDSC1 0.2795 2.4048 0.2504 50.5132
NCI-H3118 GDSC1 0.5189 6.7328 -0.6675 48.5015
SCC-9 GDSC1 0.8086 3.968 0.5782 44.6376
PCI-04B GDSC1 0.8305 4.2338 0.5353 44.5497
PE/CA-PJ15 GDSC1 1.0268 4.8636 0.5646 42.8412
DOK GDSC1 1.1934 4.1515 0.9527 40.233
SCC-4 GDSC1 1.274 2.6857 1.2629 38.1657
SCC-15 GDSC1 1.2894 3.9818 1.0987 38.8813
BHY GDSC1 1.3904 3.7477 1.2591 37.3714
JHU-011 GDSC1 1.4128 5.2092 0.8671 38.9375
KOSC-2 GDSC1 1.7043 5.4471 1.0948 35.9838
BICR 10 GDSC1 1.7342 2.2902 1.7342 32.3464
Ca9-22 GDSC1 1.7456 4.1574 1.5534 33.36
HO-1-N-1 GDSC1 1.8022 3.1525 1.7821 31.6223
SCC-25 GDSC1 1.8075 3.5037 1.7502 31.7875
PCI-15A GDSC1 2.1226 7.1969 0.8018 34.66
BICR 31 GDSC1 2.22 4.4644 1.9876 27.7696
CAL-27 GDSC1 2.3255 6.0831 1.498 30.1171
JHU-022 GDSC1 2.3873 5.3571 1.8592 27.6148
SAT [Human HNSCC] GDSC1 2.5747 5.3168 2.0744 25.1744
PCI-06A GDSC1 2.6231 6.2887 1.716 27.1937
OSC-19 GDSC1 2.6427 5.7094 1.9863 25.3831
SKN-3 GDSC1 2.8538 5.7855 2.1731 23.0189
OSC-20 GDSC1 2.8973 5.2525 2.4419 20.9255
PCI-30 GDSC1 2.9433 9.8017 0.3626 32.1874
HSC-3 GDSC1 3.2855 5.8033 2.6059 17.791
CAL-33 GDSC1 3.4047 6.7545 2.2766 19.609
Detroit 562 GDSC1 4.2628 6.4152 3.2256 8.8594
LB771-HNC GDSC1 5.092 7.4463 3.3455 5.3139
BICR 78 GDSC1 5.2079 8.6341 2.8522 8.684
HSC-2 GDSC1 6.337 7.4023 3.9821 0.0942
FaDu GDSC1 6.4483 7.8603 3.8649 0.2884
SAS GDSC1 6.4911 8.3468 3.7047 0.7798
KON GDSC1 6.5733 8.0495 3.8446 0.2893
HSC-4 GDSC1 6.6399 7.6531 4.0008 0.0377
PCI-38 GDSC1 6.6564 8.3639 3.7642 0.4702
BICR 22 GDSC1 6.7844 8.1771 3.8761 0.1611
HO-1-u-1 GDSC1 6.9001 8.4987 3.8072 0.2592
BB49-HNC GDSC1 7.0497 9.0506 3.6682 0.5555
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1710 GDSC1 1.5608 3.8601 1.421 35.3295
5637 GDSC1 1.8286 3.2664 1.8003 31.3438
639V GDSC1 2.5533 5.6771 1.9062 26.3881
RT-112 GDSC1 2.6491 4.1292 2.5451 21.5848
UM-UC-3 GDSC1 2.8146 5.5164 2.2467 22.719
BFTC-905 GDSC1 3.0016 5.097 2.6144 19.1572
T24 GDSC1 3.3922 5.8803 2.6774 16.7551
TCCSUP GDSC1 3.4327 4.6621 3.2412 12.4143
647V GDSC1 3.5011 5.88 2.7853 15.4427
HT-1376 GDSC1 3.5246 6.2864 2.6158 16.6006
J82 GDSC1 3.6356 5.7242 2.9903 13.2787
CAL-29 GDSC1 3.8884 5.2835 3.445 8.665
RT-4 GDSC1 4.8331 6.6595 3.5468 4.4907
SW780 GDSC1 4.8663 7.1363 3.3386 5.9883
KU-19-19 GDSC1 5.0191 7.8371 3.106 7.3218
HT-1197 GDSC1 5.8555 7.7253 3.6646 1.6241
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ME-180 GDSC1 0.0795 2.9595 -0.0197 52.7557
Ca Ski GDSC1 0.3789 2.9136 0.3057 49.3307
PA-1 GDSC1 0.8087 1.7545 0.8085 43.9164
OVMIU GDSC1 0.8838 4.1824 0.607 43.9083
SKN GDSC1 0.9934 2.6388 0.976 41.6975
BPH-1 GDSC1 1.1385 2.8499 1.1128 39.9344
HT-3 GDSC1 1.1597 7.3445 -0.2504 43.6306
HeLa GDSC1 1.2343 2.1649 1.2338 38.5984
TC-YIK GDSC1 1.2766 4.6388 0.9068 39.7809
DSH1 GDSC1 1.4594 3.9342 1.2946 36.703
DoTc2 4510 GDSC1 1.6511 5.1331 1.1513 36.0799
OMC-1 [Human cervical carcinoma] GDSC1 1.6961 4.8721 1.2892 35.1112
UWB1.289 GDSC1 1.7888 5.4814 1.1724 35.071
SW954 GDSC1 1.8531 3.8883 1.7324 31.6097
NCC-IT GDSC1 2.0288 5.0955 1.5724 31.4586
OVCA433 GDSC1 2.1142 4.9656 1.7105 30.129
NT2-D1 GDSC1 2.2194 4.0065 2.1052 27.0129
JAR GDSC1 2.243 3.7901 2.173 26.4328
HEY GDSC1 2.3069 5.8207 1.5883 29.7115
NEC8 GDSC1 2.438 5.1729 1.9839 26.5302
SW962 GDSC1 2.4406 4.4935 2.2195 24.9629
KGN GDSC1 2.6126 4.5363 2.3938 22.8112
C-4-I GDSC1 2.6192 4.4592 2.4244 22.5668
LB831-BLC GDSC1 2.7397 5.139 2.3193 22.6186
CAL-39 GDSC1 2.8422 5.0985 2.4443 21.2004
PWR-1E GDSC1 2.8648 3.5688 2.8581 18.2558
JHOS-3 GDSC1 2.9146 6.3277 1.9944 23.9055
ACC-OV7 GDSC1 2.9181 6.3448 1.9902 23.9154
MS751 GDSC1 2.9729 4.1924 2.8829 17.4478
HEC-1 GDSC1 2.9911 5.0103 2.637 19.0522
C-33 A GDSC1 3.0501 8.3871 1.1518 28.1782
SiSo GDSC1 3.7101 5.1443 3.3325 10.3444
PEO1 GDSC1 3.8963 6.9825 2.6222 14.951
OV17R GDSC1 4.3028 9.7115 1.6112 20.2682
JEG-3 GDSC1 4.3954 6.3014 3.3928 7.0648
SiHa GDSC1 4.4106 6.5048 3.3035 7.7144
SW756 GDSC1 4.9303 10.8608 1.5446 18.4351
OVCA420 GDSC1 5.4575 7.5828 3.5125 3.2558
SKG-IIIa GDSC1 6.4346 7.9323 3.8342 0.3757
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5980).
2 Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nat Chem Biol. 2005 Jul;1(2):74-84.