Details of the Drug

General Information of Drug (ID: DMSDVKK)

Drug Name

PF-07059013

Synonyms

PF-07059013; 6-{(1S)-1-[(2-amino-6-fluoroquinolin-3-yl)oxy]ethyl}-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one; 2435610-93-6; 6-((1S)-1-((2-Amino-6-fluoroquinolin-3-yl)oxy)ethyl)-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one; FXK42BP3GL; CHEMBL4650304; SCHEMBL21988630; GTPL12786; BDBM50565929; compound 23 [PMID: 33356244]; HY-139293; CS-0188516; PF07059013; 6-[(1S)-1-(2-amino-6-fluoroquinolin-3-yl)oxyethyl]-5-pyrazol-1-yl-1H-pyridin-2-one; (S)-6-(1-((2-Amino-6-fluoroquinolin-3-yl)oxy)ethyl)-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one; 2(1H)-Pyridinone, 6-((1S)-1-((2-amino-6-fluoro-3-quinolinyl)oxy)ethyl)-5-(1H-pyrazol-1-yl)-; VUD

Indication

Disease Entry	ICD 11	Status	REF
Sickle-cell disorder	3A51	Phase 1	[1]

Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C19H16FN5O2
Canonical SMILES: CC(C1=C(C=CC(=O)N1)N2C=CC=N2)OC3=C(N=C4C=CC(=CC4=C3)F)N
InChI: InChI=1S/C19H16FN5O2/c1-11(18-15(5-6-17(26)24-18)25-8-2-7-22-25)27-16-10-12-9-13(20)3-4-14(12)23-19(16)21/h2-11H,1H3,(H2,21,23)(H,24,26)/t11-/m0/s1
InChIKey: CLEFVPILGAPOTG-NSHDSACASA-N

Cross-matching ID

PubChem CID: 146591762
ChEBI ID: CHEMBL4650304
UNII: FXK42BP3GL
DrugBank ID: DB18122
TTD ID: DSEP59

Drug-Molecule Activity Atlas (DMA)^NEW

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hemoglobin subunit beta (HBB)	TTM6HK1	HBB_HUMAN	Modulator	[2]

Molecular Interaction Atlas (MIA)

MIA Detail

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References

1	ClinicalTrials.gov (NCT04323124) A PHASE 1, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, SINGLE AND MULTIPLE DOSE ESCALATION STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF PF-07059013 AND OPEN-LABEL ASSESSMENT OF FOOD AND FORMULATION ON PHARMACOKINETICS OF PF-07059013 IN HEALTHY ADULT PARTICIPANTS. U.S.National Institutes of Health.
2	PF-07059013: A non-covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease. Am J Hematol. 2021 Aug 1;96(8):E272-E275.