Details of the Drug

General Information of Drug (ID: DMSLE03)

Drug Name
PF-562271
Synonyms PF-00562271
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 507.5
Logarithm of the Partition Coefficient (xlogp) 2
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 12
Chemical Identifiers
Formula
C21H20F3N7O3S
IUPAC Name
N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide
Canonical SMILES
CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C
InChI
InChI=1S/C21H20F3N7O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30)
InChIKey
MZDKLVOWGIOKTN-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11713159
ChEBI ID
CHEBI:91370
CAS Number
717907-75-0
TTD ID
D01SJT
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Focal adhesion kinase 1 (FAK) TTON5IT FAK1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 2.2189 4.2485 0.5502 3.8259
G-292 clone A141B1 GDSC1 -1.9881 19.6935 -10.7296 48.3615
MHH-ES-1 GDSC1 0.0803 8.5247 -3.3399 34.2315
EW-13 GDSC1 0.6614 3.1671 -0.1779 14.8511
EW-16 GDSC1 0.8467 2.8352 0.1586 11.4645
EW-18 GDSC1 1.1219 2.7323 0.4643 7.9307
EW-7 GDSC1 1.1245 3.0143 0.3269 8.9954
SK-PN-DW GDSC1 1.1711 2.8139 0.4678 7.7062
ES1 GDSC1 1.2492 2.3696 0.7577 5.1217
SK-ES-1 GDSC1 1.2606 4.2663 -0.1793 12.4068
HOS GDSC1 1.4209 3.153 0.5111 6.4334
CAL-72 GDSC1 1.4558 7.9933 -1.8797 22.794
CHSA8926 GDSC1 1.5241 25.2226 -10.4374 40.5615
EW-1 GDSC1 1.5325 3.6164 0.3694 7.1642
H-EMC-SS GDSC1 1.5387 3.7276 0.3189 7.5393
CAL-78 GDSC1 1.6393 14.5118 -4.9872 33.0702
CHSA0108 GDSC1 1.6799 8.0957 -1.7477 21.2805
ES6 GDSC1 1.7462 4.1286 0.2801 7.1685
ES8 GDSC1 1.7602 13.9234 -4.594 31.7745
NOS-1 [Human HNSCC] GDSC1 1.8093 4.4822 0.1528 7.9555
A-673 GDSC1 1.8243 3.1453 0.8152 2.8391
SJSA-1 GDSC1 1.8942 7.4733 -1.2664 17.734
MG-63 GDSC1 1.9123 9.3962 -2.2104 22.8571
CHSA0011 GDSC1 2.0302 5.2542 -0.0637 8.9306
U2OS GDSC1 2.0859 10.5928 -2.669 24.3717
HuO9 GDSC1 2.155 6.2006 -0.4368 11.3047
ES5 GDSC1 2.1814 5.5456 -0.097 8.7351
EW-11 GDSC1 2.7033 7.833 -0.8398 12.4783
ES4 GDSC1 2.7749 9.048 -1.3811 15.6665
SaOS-2 GDSC1 2.8768 12.7646 -3.1357 23.8829
EW-24 GDSC1 3.2405 4.6526 0.8938 0.417
TC-71 GDSC1 3.3065 4.7767 0.8744 0.4416
HuO-3N1 GDSC1 3.7359 6.195 0.5156 1.575
EW-3 GDSC1 4.1074 6.0914 0.709 0.5239
NY GDSC1 4.2012 12.2324 -1.9328 14.9716
ES7 GDSC1 4.4666 6.6681 0.6394 0.5492
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 149 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 1.1865 2.1476 0.8114 4.9527
MOLM-13 GDSC1 -2.2459 0.6282 -2.4027 45.4777
MV4-11 GDSC1 -1.7481 0.2769 -1.8095 39.1369
Loucy GDSC1 -0.1819 6.6277 -2.6502 33.107
ALL-PO GDSC1 -0.1171 2.1584 -0.5246 21.188
SIG-M5 GDSC1 0.2614 1.6669 0.0642 15.0115
NKM-1 GDSC1 0.3346 3.219 -0.5207 18.8907
NALM-6 GDSC1 0.3703 1.5529 0.2207 13.323
ALL-SIL GDSC1 0.3825 1.9193 0.1002 14.1117
NB4 GDSC1 0.3952 1.7296 0.1861 13.4301
GA-10 GDSC1 0.4145 1.6525 0.2347 12.9834
MOLP-8 GDSC1 0.4867 2.272 0.0622 13.8623
Mono-Mac-6 GDSC1 0.5349 8.2596 -2.8018 30.5308
SU-DHL-16 GDSC1 0.5499 1.8116 0.3204 11.6551
ST486 GDSC1 0.6053 1.8631 0.3586 11.0927
BC-1 GDSC1 0.6808 3.1224 -0.1379 14.4616
ML-2 GDSC1 0.7502 2.037 0.4357 9.8007
SU-DHL-10 GDSC1 0.7903 3.4443 -0.1903 14.3807
SU-DHL-6 GDSC1 0.7934 2.0185 0.4881 9.2005
OCI-AML-5 GDSC1 0.7993 2.5935 0.2287 11.136
SU-DHL-5 GDSC1 0.8035 1.4473 0.7258 7.4258
BL-41 GDSC1 0.8389 1.561 0.725 7.239
Reh GDSC1 0.8407 1.6651 0.6869 7.502
U266B1 GDSC1 0.8412 1.8874 0.5947 8.1742
CCRF-CEM GDSC1 0.9927 2.0686 0.6652 6.9259
697 GDSC1 0.9941 2.865 0.2822 9.8779
KE-37 GDSC1 1.006 1.7594 0.82 5.6952
BV-173 GDSC1 1.0137 1.9489 0.7418 6.2471
A4/Fukuda GDSC1 1.0148 2.3714 0.542 7.7742
H9 GDSC1 1.0221 1.7641 0.8343 5.5103
A3/Kawakami GDSC1 1.0294 2.3895 0.547 7.6722
DEL GDSC1 1.0461 2.1458 0.6804 6.5693
Kasumi-1 GDSC1 1.0755 3.9952 -0.204 13.3102
EoL-1 GDSC1 1.0844 1.9437 0.8136 5.3763
OCI-Ly19 GDSC1 1.0968 1.9781 0.8094 5.3533
P30/OHK GDSC1 1.1044 1.8624 0.8715 4.8434
RPMI-8402 GDSC1 1.1328 2.5857 0.5466 7.2426
KOPN-8 GDSC1 1.1644 2.7184 0.5093 7.4072
RS4;11 GDSC1 1.1826 4.0937 -0.1598 12.554
BE-13 GDSC1 1.1855 2.1156 0.8263 4.8406
P32/ISH GDSC1 1.1887 1.9371 0.9165 4.1252
PF-382 GDSC1 1.19 2.5106 0.6352 6.3179
NK-92MI GDSC1 1.1964 3.5983 0.0993 10.4961
P12-Ichikawa GDSC1 1.2049 2.1011 0.8511 4.567
SUP-HD1 GDSC1 1.2071 2.8727 0.4704 7.5447
KCL-22 GDSC1 1.21 2.6056 0.6058 6.4692
Karpas-45 GDSC1 1.2366 2.5047 0.6794 5.7866
TUR GDSC1 1.2627 3.5265 0.1922 9.5176
MOLT-4 GDSC1 1.2769 2.9957 0.4694 7.2855
DND-41 GDSC1 1.278 2.5989 0.6684 5.7136
PL-21 GDSC1 1.284 4.0252 -0.0389 11.2394
OPM-2 GDSC1 1.311 4.1414 -0.0743 11.4128
QIMR-WIL GDSC1 1.3228 2.8106 0.601 6.0777
SUP-M2 GDSC1 1.3293 2.1273 0.948 3.3175
Ramos.2G6.4C10 GDSC1 1.3352 2.3446 0.8444 4.1129
MC116 GDSC1 1.3437 2.1896 0.929 3.414
SU-DHL-8 GDSC1 1.3719 2.4169 0.8388 4.0231
HL-60 GDSC1 1.3784 2.8002 0.6525 5.4691
NOMO-1 GDSC1 1.3787 3.2061 0.4499 7.0652
BALL-1 GDSC1 1.4002 2.5497 0.7957 4.2632
WSU-NHL GDSC1 1.4218 2.6222 0.777 4.3355
OCI-AML-2 GDSC1 1.4357 2.5532 0.8226 3.9285
VL51 GDSC1 1.4479 3.6403 0.2896 8.0816
CTV-1 GDSC1 1.4569 4.1681 0.0332 10.0523
JJN-3 GDSC1 1.4762 3.2239 0.5203 6.1694
Karpas-231 GDSC1 1.497 2.505 0.8944 3.162
CA46 GDSC1 1.5177 3.6523 0.3398 7.4467
Karpas-422 GDSC1 1.526 2.786 0.7774 3.985
NU-DUL-1 GDSC1 1.5323 2.8307 0.7601 4.1004
DoHH2 GDSC1 1.5372 2.8249 0.7667 4.0333
EM-2 GDSC1 1.5476 3.3048 0.5364 5.8034
SR GDSC1 1.5695 3.9725 0.2212 8.2002
KMOE-2 GDSC1 1.5704 3.182 0.6151 5.113
WIL2 NS GDSC1 1.5809 3.2743 0.5774 5.3743
SUP-T1 GDSC1 1.586 3.533 0.4528 6.333
ATN-1 GDSC1 1.5941 3.4882 0.4814 6.083
Farage GDSC1 1.6083 2.8844 0.7906 3.6258
GDM-1 GDSC1 1.6305 3.85 0.3299 7.1499
L-363 GDSC1 1.6616 3.3981 0.5772 5.1212
MOLT-16 GDSC1 1.6672 3.1866 0.6854 4.2642
HC-1 GDSC1 1.6823 3.8061 0.3913 6.5049
SCC-3 GDSC1 1.699 2.9443 0.8264 3.0873
SUP-B15 GDSC1 1.6994 5.3515 -0.3632 12.23
CTB-1 GDSC1 1.7091 3.2432 0.6881 4.1195
Hs 445 GDSC1 1.7225 2.9061 0.8611 2.7598
KMS-12-BM GDSC1 1.7304 4.1774 0.244 7.498
HEL GDSC1 1.7556 3.2536 0.7161 3.7713
LC4-1 GDSC1 1.8123 3.9002 0.4413 5.7195
HT GDSC1 1.815 3.4313 0.6716 3.9458
BC-3 GDSC1 1.8179 3.5998 0.5919 4.5461
JURL-MK1 GDSC1 1.8192 3.5697 0.6075 4.4228
Namalwa GDSC1 1.8212 3.582 0.603 4.4522
Daudi GDSC1 1.8236 3.2693 0.7555 3.2877
GR-ST GDSC1 1.8389 3.8422 0.4889 5.276
YT GDSC1 1.8645 3.7138 0.5693 4.5878
AMO1 GDSC1 1.8889 3.1938 0.8343 2.5391
K-562 GDSC1 1.8911 3.6919 0.5984 4.2937
EB2 GDSC1 1.9002 3.4859 0.7035 3.4784
Jiyoye GDSC1 1.9425 4.3425 0.319 6.2795
VAL GDSC1 1.9494 3.8284 0.5727 4.3318
Ku812 GDSC1 1.9519 3.9362 0.5225 4.7037
JSC-1 GDSC1 1.9872 3.7121 0.6534 3.6302
Raji GDSC1 2.0012 4.4464 0.31 6.181
Sc-1 GDSC1 2.0055 4.579 0.2486 6.6361
KG-1 GDSC1 2.0148 3.851 0.6057 3.9143
L-540 GDSC1 2.0324 4.1564 0.4716 4.8725
DB GDSC1 2.049 4.0426 0.5372 4.338
TK [Human B-cell lymphoma] GDSC1 2.0649 3.5488 0.7791 2.5343
SK-MM-2 GDSC1 2.0675 4.6314 0.2668 6.323
CESS GDSC1 2.0769 4.1883 0.4863 4.6454
U-698-M GDSC1 2.0863 4.5557 0.3164 5.8963
MN-60 GDSC1 2.105 4.2904 0.4563 4.7968
MHH-PREB-1 GDSC1 2.1149 4.4032 0.4092 5.1231
KY821 GDSC1 2.1151 3.6505 0.7628 2.54
MY-M12 GDSC1 2.1212 3.9488 0.6285 3.4873
MLMA GDSC1 2.1454 5.416 -0.0595 8.5596
MEG-01 GDSC1 2.1657 4.4115 0.439 4.7705
THP-1 GDSC1 2.2016 4.3343 0.4989 4.2408
SU-DHL-1 GDSC1 2.2362 3.4864 0.9042 1.3731
L-1236 GDSC1 2.2396 4.5045 0.4433 4.5558
EJM GDSC1 2.3157 4.5084 0.4898 4.0374
RC-K8 GDSC1 2.329 3.991 0.7339 2.307
JVM-3 GDSC1 2.3622 4.1706 0.6726 2.6556
EHEB GDSC1 2.4339 4.4514 0.5877 3.0916
KM-H2 GDSC1 2.4378 4.4685 0.5823 3.1212
OCI-M1 GDSC1 2.4476 3.8288 0.8673 1.2751
Granta-519 GDSC1 2.4985 4.8872 0.4274 4.0718
HH [Human lymphoma] GDSC1 2.5008 10.4706 -2.2858 21.3302
HDLM-2 GDSC1 2.5083 5.4345 0.1786 5.8318
HAL-01 GDSC1 2.6183 6.6959 -0.3492 9.3496
Karpas-299 GDSC1 2.6496 4.8981 0.5116 3.1819
LAMA-84 GDSC1 2.6503 4.5526 0.664 2.1897
LP-1 GDSC1 2.6548 4.8211 0.5488 2.924
ARH-77 GDSC1 2.7082 6.2523 -0.0777 7.1854
RPMI-8226 GDSC1 2.7607 5.8719 0.1338 5.5601
OCI-AML-3 GDSC1 2.8412 4.2618 0.8763 0.7743
ME1 GDSC1 2.9325 4.1668 0.95 0.4121
Karpas-620 GDSC1 2.9955 5.0858 0.6154 1.9526
WSU-DLCL2 GDSC1 3.0113 4.1573 0.9838 0.2674
P31/FUJ GDSC1 3.0787 4.505 0.8837 0.5521
IM-9 GDSC1 3.0966 4.4305 0.9183 0.4198
JVM-2 GDSC1 3.2018 7.5208 -0.3574 7.9464
RL GDSC1 3.6323 4.9088 0.9477 0.1429
SU-DHL-4 GDSC1 3.6554 5.0555 0.9059 0.2129
RPMI-8866 GDSC1 3.8432 5.4842 0.8252 0.3282
L-428 GDSC1 4.1752 5.8715 0.8111 0.2472
DG-75 GDSC1 4.4138 6.4033 0.7132 0.38
ROS-50 GDSC1 4.6197 6.4745 0.7622 0.2187
RPMI-6666 GDSC1 5.8859 22.4675 -5.7042 24.8455
⏷ Show the Full List of 149 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-50 GDSC1 0.5014 1.7024 0.3103 11.9825
KYSE-220 GDSC1 1.2391 2.7719 0.5485 6.8068
TE-12 GDSC1 2.1672 6.7343 -0.6906 13.0597
HCE-4 GDSC1 2.8368 4.6094 0.735 1.4928
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 1.7701 4.1138 0.3053 6.8988
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC1 0.6247 2.8214 -0.0492 14.0427
SK-N-MC-IXC GDSC1 0.8978 1.7788 0.7 7.1164
SJNB-7 GDSC1 0.9768 2.2932 0.5433 7.9304
IMR-5 GDSC1 0.9914 1.8512 0.7641 6.1836
SJNB-14 GDSC1 1.1201 2.8409 0.4089 8.3708
NB(TU)1 GDSC1 1.1494 3.5384 0.0883 10.7632
NB69 GDSC1 1.24 2.5972 0.6364 6.1114
SK-N-SH GDSC1 1.2497 2.9847 0.4515 7.5292
NH-12 GDSC1 1.3211 3.131 0.4393 7.3583
MHH-NB-11 GDSC1 1.3372 3.123 0.4569 7.1602
SK-N-BE(2)-M17 GDSC1 1.6522 3.3963 0.5711 5.1981
SiMa GDSC1 1.7383 3.7408 0.4654 5.7553
TGW GDSC1 1.7517 3.2652 0.7078 3.8461
NB1 GDSC1 1.7546 6.5452 -0.9142 15.941
GOTO GDSC1 1.7733 4.4585 0.1374 8.1873
KP-N-YS GDSC1 1.7926 4.1221 0.3179 6.7321
SK-N-AS GDSC1 1.8038 3.438 0.6606 4.0612
SJNB-13 GDSC1 1.8148 3.6911 0.5453 4.9118
CHP-126 GDSC1 1.8315 4.3283 0.2452 7.175
SK-N-DZ GDSC1 1.8715 3.8751 0.4961 5.1276
SJNB-17 GDSC1 1.8808 5.2468 -0.1711 10.2004
Kelly GDSC1 1.9561 4.4352 0.2834 6.512
KP-N-YN GDSC1 2.0763 3.9827 0.5836 3.9247
SJNB-5 GDSC1 2.1201 3.8993 0.6509 3.3275
LA-N-6 GDSC1 2.3742 6.1811 -0.2696 9.4517
SJNB-10 GDSC1 2.4618 4.7657 0.461 3.9154
GI-ME-N GDSC1 2.6156 12.4517 -3.1801 24.8071
SK-N-FI GDSC1 2.8711 4.794 0.6753 1.7836
SJNB-12 GDSC1 3.3609 6.0013 0.4149 2.5913
SJNB-6 GDSC1 3.3725 5.7834 0.5116 2.0246
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 1.4112 4.1463 0.0067 10.421
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EFM-192A GDSC1 -0.5286 4.1759 -1.8218 31.3479
CAL-51 GDSC1 0.2563 1.8576 -0.0105 15.5665
HCC70 GDSC1 0.3784 1.2633 0.313 12.647
EFM-19 GDSC1 0.6428 8.2154 -2.6847 29.6399
CAL-85-1 GDSC1 0.6732 4.852 -0.9891 20.6255
MRK-nu-1 GDSC1 0.7531 2.1872 0.3717 10.2652
MDA-MB-468 GDSC1 0.9515 2.5864 0.3781 9.315
MCF-7 GDSC1 0.9772 1.8062 0.7699 6.2082
DU4475 GDSC1 1.0885 3.182 0.2116 10.0419
MDA-MB-231 GDSC1 1.1889 8.7072 -2.4597 26.5761
HCC2157 GDSC1 1.2235 2.709 0.5662 6.7276
OCUB-M GDSC1 1.3611 5.5566 -0.74 16.1553
CAL-120 GDSC1 1.39 8.8821 -2.3787 25.4728
HCC1599 GDSC1 1.5499 2.8337 0.7719 3.9518
CAL-148 GDSC1 1.6633 2.8555 0.8445 3.0496
ZR-75-30 GDSC1 1.6822 3.4011 0.591 4.9508
HCC1806 GDSC1 1.8401 3.9812 0.4218 5.7882
BT-20 GDSC1 1.9015 8.9412 -1.992 21.8068
CAMA-1 GDSC1 1.9715 10.822 -2.8742 25.5942
JIMT-1 GDSC1 1.979 4.8412 0.1015 7.8327
COLO 824 GDSC1 2.0665 6.2092 -0.5068 12.0808
MDA-MB-415 GDSC1 2.3737 10.135 -2.2168 21.3913
HCC1500 GDSC1 2.3869 4.1077 0.7148 2.3255
HCC2218 GDSC1 2.4717 5.196 0.2673 5.2782
AU565 GDSC1 2.4767 4.5876 0.5512 3.2552
BT-549 GDSC1 2.6425 13.5791 -3.7192 26.6505
HCC1569 GDSC1 2.6428 4.8796 0.516 3.1654
HDQ-P1 GDSC1 2.6647 5.5111 0.2415 5.0166
MDA-MB-175-VII GDSC1 2.6873 7.5068 -0.6929 11.5417
HCC1187 GDSC1 2.6902 6.6644 -0.2854 8.7083
HCC1428 GDSC1 2.7995 5.153 0.4828 3.0911
BT-474 GDSC1 3.0707 4.5696 0.8562 0.6643
Evsa-T GDSC1 3.1517 4.7322 0.8285 0.7118
MDA-MB-436 GDSC1 3.2404 8.82 -0.9464 11.721
HCC38 GDSC1 3.2618 6.2564 0.2527 3.7493
UACC-812 GDSC1 3.2928 5.1367 0.7337 0.9949
HCC1954 GDSC1 3.4431 6.4941 0.2472 3.4747
T-47D GDSC1 3.6288 11.6 -2.0177 16.8216
HCC1419 GDSC1 3.6806 5.0644 0.9118 0.194
BT-483 GDSC1 3.7718 7.5628 -0.0404 4.7019
Hs 578T GDSC1 3.7925 5.9822 0.6231 1.0359
MDA-MB-453 GDSC1 3.8521 12.0977 -2.1037 16.6848
UACC-893 GDSC1 3.8574 6.3911 0.4928 1.558
MDA-MB-361 GDSC1 4.0222 12.6618 -2.2587 17.0198
MDA-MB-330 GDSC1 4.0935 6.7572 0.4541 1.5049
MDA-MB-157 GDSC1 4.3386 6.348 0.7049 0.43
MFM-223 GDSC1 4.3736 6.0183 0.8307 0.1646
HCC1395 GDSC1 4.5407 11.0662 -1.1715 10.0769
HCC1937 GDSC1 6.5362 20.41 -4.2768 19.5679
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-566MG GDSC1 0.5092 4.7988 -1.1135 22.1605
U-251MG GDSC1 0.67 6.2782 -1.6977 24.9229
D-336MG GDSC1 0.6993 5.3182 -1.1958 21.8513
SNB-75 GDSC1 0.9331 5.9172 -1.2859 21.434
LN-18 GDSC1 1.049 2.9904 0.2708 9.7397
SK-MG-1 GDSC1 1.1084 3.767 -0.0615 12.0861
Onda 10 GDSC1 1.1424 5.2895 -0.7914 17.3489
Becker GDSC1 1.1882 13.9759 -5.0942 34.6497
ONS-76 GDSC1 1.197 3.3384 0.2294 9.4756
H4 GDSC1 1.3023 6.949 -1.4852 21.1779
LNZTA3WT4 GDSC1 1.3205 3.7721 0.1183 9.8811
SF295 GDSC1 1.3915 5.2786 -0.5757 14.8734
MOG-G-UVW GDSC1 1.4472 3.7008 0.2588 8.3256
GB-1 GDSC1 1.4738 2.9018 0.679 4.9295
A-172 GDSC1 1.4847 3.2697 0.5043 6.2666
NMC-G1 GDSC1 1.5108 4.0738 0.124 9.1586
KS-1 [Human Krukenberg tumour] GDSC1 1.5737 5.8763 -0.7252 15.2784
DBTRG-05MG GDSC1 1.5794 8.8414 -2.2021 23.9675
YKG-1 GDSC1 1.603 3.3313 0.566 5.3928
D-423MG GDSC1 1.6257 7.1558 -1.3222 19.0118
Daoy GDSC1 1.7225 3.583 0.5313 5.2921
M059J GDSC1 1.7764 6.5553 -0.9021 15.7846
SF539 GDSC1 1.7872 4.191 0.2799 7.0425
D283 Med GDSC1 1.7874 3.4934 0.6221 4.401
CAS-1 GDSC1 1.7913 5.9757 -0.6018 13.654
KNS-42 GDSC1 1.8591 4.567 0.1482 7.8373
GI-1 GDSC1 1.942 6.5477 -0.7691 14.3233
KALS-1 GDSC1 1.9737 4.277 0.3729 5.7797
8-MG-BA GDSC1 2.0062 7.4897 -1.1871 16.8643
D-263MG GDSC1 2.0519 4.2975 0.4171 5.2302
AM-38 GDSC1 2.0569 5.6918 -0.259 10.3068
Onda 11 GDSC1 2.2307 4.2499 0.557 3.7497
MOG-G-CCM GDSC1 2.2376 14.3178 -4.4056 29.8861
Hs 683 GDSC1 2.2834 6.7481 -0.6115 12.1534
SF126 GDSC1 2.2911 10.7622 -2.5923 23.3863
LN-229 GDSC1 2.294 5.7816 -0.1321 8.6739
SF268 GDSC1 2.3156 8.7822 -1.5907 18.2781
U-87MG ATCC GDSC1 2.4584 5.1453 0.2825 5.1998
PFSK-1 GDSC1 2.5905 6.3072 -0.1816 8.2286
D-542MG GDSC1 2.6407 4.5516 0.6593 2.2356
GaMG GDSC1 2.8957 10.5777 -2.043 18.956
D-247MG GDSC1 3.1317 10.5303 -1.8486 17.2764
KINGS-1 GDSC1 3.2699 11.8272 -2.3828 19.5623
42-MG-BA GDSC1 3.2712 12.1007 -2.5158 20.1723
KNS-81-FD GDSC1 3.5031 11.4 -2.0086 17.1035
SW1783 GDSC1 3.5496 6.5043 0.2985 2.9959
U-118MG GDSC1 3.6935 5.7495 0.6698 0.9244
LN-405 GDSC1 3.8509 5.4796 0.8297 0.3146
D-502MG GDSC1 4.0171 5.8306 0.7678 0.4025
D-392MG GDSC1 4.2907 10.0203 -0.8434 8.6727
YH-13 GDSC1 4.4571 15.5612 -3.3575 20.6736
DK-MG GDSC1 4.7713 18.4521 -4.5399 23.9507
T98G GDSC1 5.3192 15.7958 -2.8882 16.8868
SW1088 GDSC1 5.5881 26.0737 -7.6777 29.5169
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 1.2098 6.7943 -1.4859 21.5361
TGBC24TKB GDSC1 1.9859 4.8493 0.1026 7.8044
TGBC1TKB GDSC1 2.7138 8.0009 -0.914 12.9353
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1 0.2975 1.8195 0.0479 14.9328
MFE-319 GDSC1 0.9567 3.1611 0.1024 11.4295
MFE-296 GDSC1 1.048 9.4823 -2.9665 29.1551
RL95-2 GDSC1 1.4284 3.2801 0.4537 6.8592
ESS-1 GDSC1 1.4487 2.9065 0.6567 5.1896
EN GDSC1 1.8491 3.5298 0.6477 4.0345
KLE GDSC1 2.4964 5.7702 0.0118 7.074
MFE-280 GDSC1 2.8694 8.1891 -0.8962 12.3848
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RCC10RGB GDSC1 -0.0022 7.4178 -2.8697 33.0691
SN12C GDSC1 0.6961 3.7556 -0.43 16.5849
786-O GDSC1 1.0855 3.3881 0.1066 10.8724
ACHN GDSC1 1.5469 3.5471 0.4153 6.7562
UO-31 GDSC1 1.6809 3.3648 0.608 4.8233
LB1047-RCC GDSC1 1.9224 7.6284 -1.3215 17.9764
RXF 393L GDSC1 1.9387 26.3885 -10.678 39.9512
SW13 GDSC1 2.027 5.7558 -0.3126 10.7944
VMRC-RCZ GDSC1 2.1562 16.2636 -5.4418 32.623
BFTC-909 GDSC1 2.1757 4.2921 0.5021 4.2806
A-498 GDSC1 2.3246 4.4472 0.5238 3.7735
OS-RC-2 GDSC1 2.38 13.2962 -3.7835 27.6184
CAL-54 GDSC1 2.4095 5.3981 0.1312 6.4237
LB996-RCC GDSC1 2.5548 5.9873 -0.0528 7.3932
SW156 GDSC1 2.781 5.673 0.2379 4.787
A-704 GDSC1 2.9846 5.7432 0.325 3.7851
HA7-RCC GDSC1 3.1586 5.6633 0.4544 2.663
TK-10 GDSC1 3.417 11.8041 -2.2658 18.6078
LB2241-RCC GDSC1 3.4712 11.2203 -1.9438 16.8552
VMRC-RCW GDSC1 3.6895 5.2817 0.8395 0.3548
Caki-1 GDSC1 4.0555 20.0945 -5.8695 28.9699
769-P GDSC1 4.4266 14.4149 -2.8254 18.6073
KMRC-20 GDSC1 4.431 5.8884 0.8932 0.0801
BB65-RCC GDSC1 4.8602 19.723 -5.096 25.3351
KMRC-1 GDSC1 5.5252 21.4914 -5.4841 24.9908
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KM12 GDSC1 -1.3443 0.0775 -1.3639 33.8764
COLO205 GDSC1 -1.0654 1.2734 -1.2644 31.5009
SW48 GDSC1 0.1743 1.1987 0.1057 15.2171
GP5d GDSC1 0.4803 1.8351 0.2372 12.6158
HCT 116 GDSC1 0.7251 2.5275 0.1872 11.7903
SW620 GDSC1 0.7718 1.6568 0.617 8.3643
RKO GDSC1 1.046 1.9627 0.7671 5.906
LS411N GDSC1 1.2196 2.4775 0.678 5.8646
SNU-C1 GDSC1 1.3091 2.6606 0.6643 5.629
HCC2998 GDSC1 1.3203 3.2162 0.3961 7.7014
LS180 GDSC1 1.3493 3.1365 0.4603 7.0897
NCI-H747 GDSC1 1.3667 4.126 -0.02 10.788
SW626 GDSC1 1.5498 3.7139 0.3345 7.3796
SW948 GDSC1 1.6377 3.4464 0.5354 5.5217
COLO 320HSR GDSC1 1.7733 4.0211 0.3533 6.517
HT115 GDSC1 1.816 3.5905 0.5952 4.5266
LoVo GDSC1 1.9308 5.2354 -0.1278 9.7174
MDST8 GDSC1 2.0261 3.4763 0.7887 2.5514
SW1463 GDSC1 2.1482 8.8654 -1.7606 19.7624
NCI-H716 GDSC1 2.2073 4.0356 0.6418 3.1945
RCM-1 [Human ESC] GDSC1 2.2214 6.2402 -0.4076 10.894
C2BBe1 GDSC1 2.2268 5.0669 0.1667 6.6403
SW1417 GDSC1 2.3512 3.9377 0.77 2.0286
CCK-81 GDSC1 2.398 4.7256 0.4403 4.2048
LS513 GDSC1 2.4127 4.92 0.3589 4.7555
HT-55 GDSC1 2.5697 3.994 0.8588 1.1591
LS1034 GDSC1 2.579 6.4502 -0.2579 8.8062
HT-29 GDSC1 2.9592 10.6734 -2.0434 18.7757
CaR-1 GDSC1 3.0367 10.2161 -1.7633 17.0849
COLO 678 GDSC1 3.0589 6.426 0.0604 5.4169
SNU-C2B GDSC1 3.1496 8.3761 -0.7952 10.9847
CL-11 GDSC1 3.1723 5.6367 0.4728 2.5312
T84 GDSC1 3.3379 5.401 0.6501 1.342
SW837 GDSC1 3.3919 5.3086 0.7102 1.0088
HCT 15 GDSC1 3.536 5.0085 0.8788 0.3178
LS123 GDSC1 3.5612 11.1117 -1.8287 16.0164
CW-2 GDSC1 3.8755 5.9606 0.6656 0.8059
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.6999 5.4544 0.7817 0.5166
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 GDSC1 -0.92 0.9752 -1.0352 29.1813
Hep 3B2.1-7 GDSC1 0.9844 2.4468 0.4767 8.4105
JHH-7 GDSC1 1.0711 3.0164 0.2779 9.5934
SNU-387 GDSC1 1.1415 7.4076 -1.8503 23.8238
JHH-1 GDSC1 1.5945 3.4361 0.5075 5.8777
SNU-423 GDSC1 1.621 7.2491 -1.3726 19.3345
Hep-G2/C3A GDSC1 1.9212 5.1765 -0.106 9.5832
HLE GDSC1 2.0812 5.2436 -0.0215 8.4621
SK-HEP-1 GDSC1 2.1461 5.7905 -0.2421 9.9129
JHH-6 GDSC1 2.2807 6.8138 -0.6458 12.4005
Huh-7 GDSC1 2.3167 4.5027 0.4931 4.0113
JHH-4 GDSC1 2.4894 5.3669 0.1983 5.7354
JHH-2 GDSC1 2.7885 8.1202 -0.9193 12.7587
HuH-1 GDSC1 3.1371 4.6569 0.8508 0.6348
SNU-475 GDSC1 3.3942 4.9341 0.8515 0.4656
SNU-449 GDSC1 4.1065 15.8192 -3.7311 22.8644
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H810 GDSC1 0.0582 2.292 -0.3926 19.3341
LCLC-97TM1 GDSC1 0.1537 10.6397 -4.3222 36.4727
Lu-135 GDSC1 0.7239 2.1136 0.375 10.3807
DMS 273 GDSC1 0.8262 3.1838 -0.0297 13.0006
SW1271 GDSC1 0.853 9.1826 -2.9839 29.9522
NCI-H2122 GDSC1 0.8634 1.6476 0.718 7.16
NCI-H460 GDSC1 0.8717 2.9511 0.1261 11.6066
NCI-H3122 GDSC1 0.9674 2.5316 0.4197 8.9254
LC-2/ad GDSC1 0.9675 5.1511 -0.8742 18.6167
HCC44 GDSC1 0.993 3.1882 0.1223 11.1249
HOP-92 GDSC1 1.0457 5.7736 -1.1164 19.9099
HOP-62 GDSC1 1.0472 2.7977 0.3641 9.0191
ABC-1 GDSC1 1.0623 3.8546 -0.1457 12.9165
NCI-H211 GDSC1 1.0853 2.0326 0.7722 5.6903
LXF 289 GDSC1 1.1261 3.0397 0.3158 9.0763
NCI-H2087 GDSC1 1.1356 3.7451 -0.0268 11.711
NCI-H1975 GDSC1 1.1437 3.9054 -0.0996 12.2426
SK-LU-1 GDSC1 1.1673 8.4661 -2.3574 26.2015
IA-LM GDSC1 1.1778 2.0135 0.8691 4.5398
LCLC-103H GDSC1 1.186 6.7942 -1.5059 21.7447
SBC-3 GDSC1 1.2153 10.3918 -3.2796 29.672
NCI-H2030 GDSC1 1.2281 3.6379 0.1069 10.3154
IST-SL1 GDSC1 1.3008 3.1052 0.4351 7.4666
NCI-H1048 GDSC1 1.3672 2.7759 0.6554 5.4864
SBC-5 GDSC1 1.37 2.5085 0.7915 4.4031
NCI-H1770 GDSC1 1.3804 3.4704 0.3191 8.089
NCI-H510A GDSC1 1.3845 5.9259 -0.9052 17.2058
NCI-H2110 GDSC1 1.3879 2.8002 0.6605 5.3726
NCI-H526 GDSC1 1.3897 3.8522 0.136 9.4915
NCI-H1734 GDSC1 1.3903 3.9992 0.063 10.0589
NCI-H226 GDSC1 1.394 2.839 0.646 5.4648
NCI-H82 GDSC1 1.4054 2.4557 0.8469 3.8414
NCI-H2170 GDSC1 1.412 2.3842 0.8879 3.4955
LK-2 GDSC1 1.4186 2.5477 0.8116 4.0736
A-549 GDSC1 1.4236 3.6538 0.2631 8.3749
A-427 GDSC1 1.4349 2.917 0.6403 5.3666
NCI-H1963 GDSC1 1.4372 4.0096 0.0963 9.6315
NCI-H2171 GDSC1 1.4414 2.5385 0.8344 3.8161
NCI-H727 GDSC1 1.4595 5.1085 -0.4346 13.5959
NCI-H847 GDSC1 1.4669 3.2825 0.4836 6.4897
NCI-H647 GDSC1 1.4685 7.3748 -1.5601 20.9914
NCI-H2009 GDSC1 1.4989 3.7546 0.2737 8.0287
EBC-1 GDSC1 1.6 3.891 0.2858 7.594
NCI-H2081 GDSC1 1.6064 3.7041 0.3836 6.8081
UMC-11 GDSC1 1.6131 5.8053 -0.6581 14.6664
NCI-H522 GDSC1 1.6188 2.9563 0.763 3.8083
NCI-H290 GDSC1 1.647 3.6499 0.4417 6.2236
NCI-H292 GDSC1 1.6507 8.576 -2.0113 22.7727
HCC78 GDSC1 1.6516 3.724 0.4085 6.4682
NCI-H1304 GDSC1 1.6924 3.5627 0.5191 5.4788
COR-L23 GDSC1 1.7024 5.6118 -0.4905 13.1541
NCI-H1568 GDSC1 1.7101 4.4274 0.1046 8.6424
NCI-H358 GDSC1 1.7108 9.6902 -2.5191 24.9674
EPLC-272H GDSC1 1.7403 4.1286 0.2756 7.2218
NCI-H64 GDSC1 1.7522 3.2541 0.7135 3.801
Calu-3 GDSC1 1.7536 6.3428 -0.8142 15.2659
NCI-H2804 GDSC1 1.7573 4.6688 0.0211 9.1335
NCI-H1648 GDSC1 1.7736 6.0447 -0.65 14.0554
RERF-LC-MS GDSC1 1.7792 4.8051 -0.0297 9.4522
ChaGo-K-1 GDSC1 1.7924 3.5193 0.6131 4.4562
HCC15 GDSC1 1.8036 3.8817 0.4441 5.7242
NCI-H2347 GDSC1 1.8094 5.312 -0.2579 11.0806
Ms-1 GDSC1 1.8381 4.3373 0.2457 7.1515
SK-MES-1 GDSC1 1.8623 8.5163 -1.8114 20.9919
NCI-H2141 GDSC1 1.8816 3.6742 0.6004 4.3045
Lu-165 GDSC1 1.9068 4.5815 0.1762 7.4777
NCI-H3255 GDSC1 1.9424 5.0322 -0.0191 8.8601
NCI-H1355 GDSC1 1.9629 4.1918 0.4066 5.5534
NCI-H1836 GDSC1 1.9643 3.8422 0.5761 4.2661
BEN GDSC1 1.9711 9.1596 -2.0457 21.8459
NCI-H1437 GDSC1 1.9817 3.9549 0.5339 4.538
RERF-LC-KJ GDSC1 2.0062 3.5874 0.7246 3.0602
HARA [Human squamous cell lung carcinoma] GDSC1 2.0212 6.1223 -0.4979 12.16
NCI-H69 GDSC1 2.0279 7.5856 -1.218 16.986
NCI-H1688 GDSC1 2.0593 3.9045 0.6096 3.775
NCI-H1781 GDSC1 2.0616 5.3463 -0.0859 9.0037
NCI-H209 GDSC1 2.133 3.8984 0.6593 3.237
NCI-H2085 GDSC1 2.1631 6.1003 -0.3817 10.882
NCI-H2595 GDSC1 2.1768 6.051 -0.3474 10.5916
NCI-H2869 GDSC1 2.1792 6.6755 -0.6527 12.7596
NCI-H596 GDSC1 2.1802 4.9039 0.2132 6.4184
NCI-H187 GDSC1 2.1895 3.6899 0.7888 2.2073
NCI-H1299 GDSC1 2.1987 8.5081 -1.5442 18.3845
IST-SL2 GDSC1 2.214 4.107 0.6129 3.3855
NCI-H1694 GDSC1 2.2153 4.4267 0.4643 4.4613
Lu-99A GDSC1 2.218 4.0697 0.6326 3.2361
Lu-65 GDSC1 2.2204 4.4878 0.4387 4.6364
NCI-H2135 GDSC1 2.2249 4.1755 0.5879 3.5399
NCI-H520 GDSC1 2.2365 3.9488 0.6992 2.7279
NCI-H2228 GDSC1 2.2413 4.3684 0.5083 4.0772
NCI-H1944 GDSC1 2.271 4.5749 0.4304 4.5741
COLO 668 GDSC1 2.2732 3.9032 0.7413 2.3646
NCI-H524 GDSC1 2.2871 4.3041 0.5668 3.5507
NCI-H1703 GDSC1 2.2897 4.3744 0.5359 3.7655
NCI-H2722 GDSC1 2.3129 9.4721 -1.9347 20.1621
NCI-H2461 GDSC1 2.3335 4.1578 0.6616 2.7878
Lu-134-A GDSC1 2.3427 6.9102 -0.6477 12.2273
NCI-H661 GDSC1 2.345 5.1195 0.2211 5.9276
NCI-H1869 GDSC1 2.3559 5.4598 0.0659 7.0441
PC-14 GDSC1 2.3834 5.2298 0.194 6.0292
NCI-H1793 GDSC1 2.3935 5.3496 0.1437 6.3729
NCI-H196 GDSC1 2.4206 4.0215 0.7711 1.9003
NCI-H748 GDSC1 2.4352 7.0418 -0.6453 11.937
NCI-H2342 GDSC1 2.442 4.4375 0.5987 2.9999
NCI-H446 GDSC1 2.4629 4.7971 0.4472 4.01
Calu-6 GDSC1 2.4808 9.5063 -1.8238 19.0498
NCI-H841 GDSC1 2.5187 6.0072 -0.0864 7.7299
DMS 53 GDSC1 2.5194 4.8318 0.4654 3.7605
HCC33 GDSC1 2.5559 4.699 0.547 3.1254
Lu-139 GDSC1 2.5561 4.2551 0.7423 1.8573
NCI-H1436 GDSC1 2.5623 4.5103 0.6346 2.5306
NCI-H345 GDSC1 2.5744 3.419 1.0817 0.1978
NCI-H2196 GDSC1 2.585 4.7038 0.5615 2.9712
LB647-SCLC GDSC1 2.6824 5.0039 0.483 3.3098
NCI-H2405 GDSC1 2.7086 7.1081 -0.4857 10.0635
NCI-H2444 GDSC1 2.7389 4.0577 0.9109 0.7142
NCI-H1650 GDSC1 2.7685 10.0164 -1.8607 18.3803
NCI-H2373 GDSC1 2.7976 9.1282 -1.4039 15.7355
NCI-H441 GDSC1 2.879 9.0292 -1.2972 14.8671
LOU-NH91 GDSC1 2.884 5.6098 0.3273 3.9633
NCI-H23 GDSC1 2.9146 5.1044 0.5661 2.3671
COR-L88 GDSC1 2.9206 4.8177 0.6899 1.6327
NCI-H838 GDSC1 2.9235 10.5292 -1.9988 18.6498
NCI-H1623 GDSC1 2.9742 4.6877 0.7681 1.153
PaCa-3 GDSC1 2.9938 7.5016 -0.4823 9.2978
NCI-H1092 GDSC1 3.0468 5.1327 0.6213 1.8474
NCI-H1651 GDSC1 3.0826 8.1298 -0.7224 10.6805
NCI-H2029 GDSC1 3.0897 4.8843 0.7425 1.1547
NCI-H720 GDSC1 3.0944 4.4995 0.8921 0.5109
NCI-H2731 GDSC1 3.0993 8.3478 -0.8153 11.2454
CAL-12T GDSC1 3.1254 10.0612 -1.6245 16.0742
NCI-H1792 GDSC1 3.2377 10.3334 -1.6775 16.0602
NCI-H1993 GDSC1 3.2455 5.8499 0.4199 2.7361
NCI-H1563 GDSC1 3.2472 4.6887 0.8833 0.4468
SHP-77 GDSC1 3.3096 5.3731 0.6483 1.3817
NCI-H1838 GDSC1 3.3099 5.3783 0.6464 1.3908
NCI-H1435 GDSC1 3.3233 5.448 0.6246 1.4851
NCI-H650 GDSC1 3.3296 16.563 -4.6717 27.7014
NCI-H2795 GDSC1 3.3676 5.503 0.623 1.4439
NCI-H2227 GDSC1 3.3729 5.1137 0.7765 0.7478
NCI-H1755 GDSC1 3.3922 7.1935 -0.0911 5.7454
SBC-1 GDSC1 3.4077 4.9636 0.846 0.4754
NCI-H1876 GDSC1 3.4138 4.8434 0.8915 0.3372
EKVX GDSC1 3.4281 9.0362 -0.9248 11.1129
NCI-H1155 GDSC1 3.4808 4.9385 0.8829 0.3305
NCI-H1581 GDSC1 3.5183 5.1896 0.8071 0.5385
NCI-H1693 GDSC1 3.5295 9.0337 -0.8577 10.4445
NCI-H2818 GDSC1 3.5295 5.8133 0.5733 1.5132
COR-L95 GDSC1 3.546 5.0871 0.8547 0.378
DMS 79 GDSC1 3.5601 5.627 0.66 1.0782
NCI-H2369 GDSC1 3.6256 5.0248 0.9058 0.2224
NCI-H322M GDSC1 3.7183 7.2815 0.0533 4.2123
DMS 114 GDSC1 3.7575 5.5804 0.7584 0.5584
NCI-H1573 GDSC1 3.8299 5.4714 0.8248 0.3346
NCI-H2291 GDSC1 3.8537 6.0116 0.6375 0.9289
NCI-H2591 GDSC1 3.9324 6.9792 0.2908 2.5042
CPC-N GDSC1 3.9658 6.1402 0.6354 0.8549
COR-L105 GDSC1 4.086 15.5723 -3.6252 22.5404
HCC827 GDSC1 4.1177 6.1516 0.6914 0.5712
LC-1/sq GDSC1 4.183 6.2194 0.6921 0.5359
NCI-H1915 GDSC1 4.2692 13.559 -2.5214 17.6462
NCI-H1666 GDSC1 4.2774 6.2857 0.7041 0.4582
NCI-H513 GDSC1 4.3679 6.0746 0.8097 0.199
RERF-LC-Sq1 GDSC1 4.4958 6.6738 0.6484 0.5109
NCI-H2023 GDSC1 5.5114 19.0991 -4.3367 21.7596
SW1573 GDSC1 5.7281 17.0767 -3.2275 17.4124
NCI-H2803 GDSC1 6.4584 22.3658 -5.2608 22.6253
NCI-H2172 GDSC1 8.2335 25.7344 -5.6887 20.7318
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 3.2172 5.24 0.659 1.4312
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-180 GDSC1 0.1141 6.2096 -2.1701 29.7517
KYSE-150 GDSC1 0.3548 2.1721 -0.0319 15.2117
KYSE-510 GDSC1 0.3689 1.6208 0.1964 13.4995
KYSE-270 GDSC1 0.4279 2.7933 -0.2312 16.3242
TE-11 GDSC1 0.6421 4.3556 -0.7735 19.2925
T.T GDSC1 1.065 3.3086 0.1278 10.7897
OE33 GDSC1 1.0818 6.4663 -1.431 21.7129
TE-15 GDSC1 1.1298 2.7447 0.4653 7.8906
KYSE-450 GDSC1 1.1723 1.8866 0.9256 4.1257
KYSE-410 GDSC1 1.2044 6.2142 -1.2005 19.8219
KYSE-140 GDSC1 1.2935 2.4188 0.7718 4.8408
TE-9 GDSC1 1.3839 3.1044 0.505 6.612
TE-10 GDSC1 1.4 4.9999 -0.4293 13.773
OE19 GDSC1 1.4152 3.0317 0.567 6.0127
COLO 680N GDSC1 1.821 5.582 -0.383 11.9706
TE-6 GDSC1 1.9057 4.3556 0.2861 6.6383
TE-1 GDSC1 2.0997 8.9742 -1.8523 20.4158
KYSE-70 GDSC1 2.577 4.8926 0.472 3.5951
TE-8 GDSC1 2.6483 6.781 -0.3696 9.4135
TE-5 GDSC1 2.7531 9.4857 -1.6113 17.061
EC-GI-10 GDSC1 3.0442 4.854 0.7338 1.2476
OE21 GDSC1 3.3588 8.9403 -0.9249 11.2854
KYSE-520 GDSC1 4.3787 13.5762 -2.4555 17.086
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IGROV-1 GDSC1 -0.0363 2.0851 -0.4102 19.9542
OVTOKO GDSC1 0.3089 10.2725 -4.0023 35.1347
TOV-112D GDSC1 0.8139 3.0139 0.0411 12.5106
EFO-27 GDSC1 1.1604 4.6827 -0.4729 14.9966
OVCAR-4 GDSC1 1.3809 7.8006 -1.8455 22.89
OVCAR-3 GDSC1 1.4263 5.6758 -0.7455 15.9527
A2780 GDSC1 1.453 4.4333 -0.1025 11.1146
OVCAR-8 GDSC1 1.663 2.8649 0.8397 3.0871
OC 314 GDSC1 1.6957 3.5172 0.5439 5.276
OVCAR-5 GDSC1 1.7318 10.5983 -2.9557 26.7072
Kuramochi GDSC1 1.7734 5.9902 -0.623 13.8646
TOV-21G GDSC1 1.8596 5.2829 -0.2051 10.5227
TYK-nu GDSC1 1.8613 18.4253 -6.7612 35.7934
OAW42 GDSC1 1.9371 3.3061 0.8123 2.5849
FU-OV-1 GDSC1 2.1106 6.4076 -0.5718 12.4051
OV-90 GDSC1 2.1413 3.633 0.7864 2.3213
EFO-21 GDSC1 2.2713 5.7334 -0.1247 8.6833
RMG-I GDSC1 2.6148 4.8157 0.5286 3.1349
OAW28 GDSC1 2.707 5.5553 0.2471 4.8836
SK-OV-3 GDSC1 3.2625 11.6951 -2.3235 19.3026
Caov-3 GDSC1 3.2941 9.2652 -1.1232 12.6832
ES-2 GDSC1 3.7548 5.0062 0.9572 0.1047
OVKATE GDSC1 3.9156 5.4923 0.8487 0.2498
Caov-4 GDSC1 4.3671 6.4106 0.6934 0.4476
OVISE GDSC1 4.6444 14.2999 -2.623 17.2254
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MZ-PC-1 GDSC1 0.2555 5.655 -1.7676 27.1344
KP-4 GDSC1 1.0281 2.5752 0.4555 8.3871
BxPC-3 GDSC1 1.0663 3.2589 0.1536 10.5828
Panc 08.13 GDSC1 1.2058 2.8749 0.4681 7.568
HuP-T4 GDSC1 1.5391 3.9491 0.2088 8.3997
PaTu 8988t GDSC1 1.5916 4.4752 -0.0118 9.9344
CFPAC-1 GDSC1 1.6304 5.835 -0.6591 14.6128
HPAC GDSC1 1.6684 4.7251 -0.0757 10.1674
PaTu 8902 GDSC1 1.6841 4.5296 0.0337 9.2745
SUIT-2 GDSC1 1.7504 4.2819 0.2075 7.7178
SU.86.86 GDSC1 1.7609 4.5416 0.0868 8.6166
Panc 03.27 GDSC1 1.8451 4.2255 0.3058 6.6672
KP-1N GDSC1 1.8564 6.4423 -0.783 14.7037
Panc 02.03 GDSC1 2.2736 5.6603 -0.0875 8.4023
PL4 GDSC1 2.3064 5.2731 0.1218 6.7611
HuP-T3 GDSC1 2.3207 7.3348 -0.8724 13.8205
Panc 04.03 GDSC1 2.3343 5.23 0.1613 6.396
DAN-G GDSC1 2.5431 5.0306 0.3886 4.2478
Capan-2 GDSC1 2.786 5.0913 0.5026 2.9868
KP-2 GDSC1 2.855 6.8572 -0.268 8.1657
Capan-1 GDSC1 2.9417 7.5998 -0.5636 9.9828
AsPC-1 GDSC1 3.0854 5.6263 0.4317 2.9207
KP-3 GDSC1 3.1773 6.0761 0.2854 3.6899
YAPC GDSC1 3.3046 9.2207 -1.0948 12.4818
Panc 10.05 GDSC1 3.5115 10.1945 -1.4215 13.8953
Hs 766T GDSC1 3.737 7.2417 0.0807 4.0127
MIA PaCa-2 GDSC1 3.8611 12.1759 -2.1353 16.8187
SW1990 GDSC1 4.1797 13.1513 -2.3866 17.2411
HPAF-II GDSC1 4.5473 6.5892 0.6971 0.3688
PSN1 GDSC1 4.7315 23.3076 -6.9493 29.789
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 2.5847 4.3776 0.7047 2.0439
NCI-H2052 GDSC1 2.6516 6.5061 -0.2357 8.4557
NCI-H2452 GDSC1 3.4575 13.8123 -3.2192 22.6194
IST-Mes1 GDSC1 3.737 10.0079 -1.1828 11.9378
MSTO-211H GDSC1 4.4011 6.3143 0.7395 0.3247
NCI-H28 GDSC1 5.8194 22.2293 -5.6354 24.8013
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1 1.1828 5.9962 -1.1099 19.3278
PC-3 GDSC1 1.6551 4.2427 0.1538 8.4407
VCaP GDSC1 2.0054 4.5175 0.2785 6.4089
22Rv1 GDSC1 2.0493 6.7316 -0.778 14.0354
LNCaP clone FGC GDSC1 2.9399 6.0378 0.1664 4.9428
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 1.1725 2.0229 0.8596 4.6363
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
WM35 GDSC1 -0.426 12.151 -5.59 40.7914
COLO 829 GDSC1 -0.37 15.4752 -7.1888 42.3716
Hs 940.T GDSC1 -0.2328 4.8611 -1.8488 29.9178
Mel Ho GDSC1 0.5589 8.3252 -2.8132 30.476
A-431 GDSC1 0.5849 1.693 0.4033 10.8772
Mel JuSo GDSC1 0.667 2.3785 0.1981 11.9787
LB373-MEL-D GDSC1 0.8662 5.5189 -1.1464 20.8338
HT-144 GDSC1 0.8899 12.7565 -4.7371 34.823
IGR-1 GDSC1 1.1558 2.6949 0.5132 7.4108
A-375 GDSC1 1.2453 3.0187 0.4308 7.7086
RVH-421 GDSC1 1.2644 6.5254 -1.3054 20.2439
RPMI-7951 GDSC1 1.3806 4.3221 -0.1065 11.4057
IGR-37 GDSC1 1.4776 2.3771 0.943 2.8443
VMRC-MELG GDSC1 1.5124 7.1496 -1.4114 19.9596
CHL-1 GDSC1 1.5306 8.0673 -1.8552 22.3922
G-361 GDSC1 1.5359 4.8192 -0.2279 11.779
WM1552C GDSC1 1.538 4.5698 -0.1018 10.8109
SH-4 GDSC1 1.5765 4.4895 -0.0309 10.1328
A2058 GDSC1 1.6386 11.5287 -3.4967 28.9689
WM278 GDSC1 1.69 25.6457 -10.5115 40.2957
SK-MEL-24 GDSC1 1.6984 3.0549 0.7723 3.5028
IPC-298 GDSC1 1.7277 4.4737 0.0952 8.6587
SK-MEL-30 GDSC1 1.9189 5.1405 -0.0899 9.4685
HMV-II GDSC1 1.9448 6.304 -0.6459 13.4575
CP50-MEL-B GDSC1 2.095 3.7931 0.6845 3.1426
A101D GDSC1 2.1042 9.9288 -2.3238 22.7629
GAK GDSC1 2.2575 3.8252 0.7673 2.2202
WM115 GDSC1 2.326 6.9332 -0.6712 12.4398
451Lu GDSC1 2.3367 9.6805 -2.0198 20.5265
MZ-MEL-7 GDSC1 2.3967 7.0557 -0.6799 12.2884
CP66-MEL GDSC1 2.4225 8.4613 -1.3516 16.545
SK-MEL-28 GDSC1 2.5099 3.6117 0.984 0.5985
A-388 GDSC1 2.5749 11.3625 -2.6711 22.859
LB2518-MEL GDSC1 2.6018 10.1479 -2.0497 19.8592
MMAc-SF GDSC1 2.6816 6.821 -0.3662 9.3006
DJM-1 GDSC1 2.7021 6.5185 -0.2079 8.1276
SK-MEL-2 GDSC1 2.7342 8.9897 -1.382 15.7906
SK-MEL-3 GDSC1 2.8215 4.1219 0.9215 0.5974
COLO 792 GDSC1 3.0189 7.6406 -0.5318 9.5701
LOX-IMVI GDSC1 3.0521 10.6905 -1.9841 18.208
COLO 783 GDSC1 3.1964 5.0266 0.7343 1.0844
G-mel GDSC1 3.2838 5.0218 0.774 0.8285
SK-MEL-1 GDSC1 3.289 4.8648 0.8352 0.5859
UACC-62 GDSC1 3.2906 11.8887 -2.3979 19.576
SK-MEL-5 GDSC1 3.4446 5.0372 0.8337 0.4942
WT2-iPS GDSC1 3.5234 4.7412 0.9664 0.1375
MeWo GDSC1 3.5693 5.031 0.8832 0.2933
Hs 938.T GDSC1 3.646 12.6942 -2.5364 19.2671
IST-MEL1 GDSC1 3.6928 13.1783 -2.7389 20.0416
M14 GDSC1 3.7042 5.2434 0.8584 0.3013
COLO 800 GDSC1 3.7353 5.5158 0.7733 0.5237
UACC-257 GDSC1 3.9053 9.8335 -0.9932 10.4062
COLO 679 GDSC1 3.9861 18.6385 -5.2032 27.5389
WM793 GDSC1 4.3942 27.5338 -9.295 34.0592
MZ-MEL-2 GDSC1 4.8349 19.9223 -5.2116 25.6955
EquiPSC Line K2 GDSC1 0.9334 8.8026 -2.725 28.6553
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 0.3104 1.9154 0.0251 15.0272
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW982 GDSC1 -1.4583 11.2821 -6.1111 45.0974
MES-SA GDSC1 0.1444 1.5834 -0.0346 16.3414
SK-UT-1 GDSC1 0.1647 1.9821 -0.156 17.0875
STS-0421 GDSC1 0.4965 4.3074 -0.8854 20.7088
VA-ES-BJ GDSC1 0.7944 3.8098 -0.3654 15.6826
Hs 633.T GDSC1 0.8473 2.3933 0.3701 9.8388
MFH-ino GDSC1 1.0764 3.2775 0.1534 10.5442
SW872 GDSC1 1.1114 4.5741 -0.461 15.0998
G-401 GDSC1 1.2191 4.5449 -0.3538 13.8858
EW-8 GDSC1 1.3222 2.2991 0.8561 4.0687
A-204 GDSC1 1.4095 10.2131 -3.028 28.0855
TE 441.T GDSC1 1.4146 2.5918 0.7864 4.2864
SK-LMS-1 GDSC1 1.5533 2.9657 0.7091 4.4319
G-402 GDSC1 1.5819 12.7531 -4.1553 31.1583
HT-1080 GDSC1 1.6285 4.4448 0.0325 9.4682
Rh30 GDSC1 1.8481 3.9814 0.4275 5.7216
RD GDSC1 1.903 6.1801 -0.6166 13.3874
KYM-1 GDSC1 2.5509 4.5753 0.5994 2.7833
Rh41 GDSC1 2.8395 4.9917 0.575 2.4335
RKN GDSC1 4.2447 11.1021 -1.3713 11.8499
SW684 GDSC1 4.4701 17.1796 -4.1345 23.3644
GCT GDSC1 5.337 18.6822 -4.2556 21.8622
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 GDSC1 0.3853 1.2941 0.3129 12.6078
AGS GDSC1 0.5639 4.7303 -1.0294 21.3703
IM95 GDSC1 0.6184 3.436 -0.3482 16.3201
TMK-1 GDSC1 0.6215 3.5454 -0.3981 16.6767
ECC10 GDSC1 0.8459 4.339 -0.5793 17.0406
ECC12 GDSC1 1.458 3.0206 0.6072 5.5483
MKN1 GDSC1 1.4981 4.83 -0.264 12.1846
RF-48 GDSC1 1.5259 3.1047 0.619 5.2271
Fu97 GDSC1 1.6313 3.2921 0.6068 4.9846
SNU-1 GDSC1 1.7626 4.1551 0.2792 7.1241
NUGC-4 GDSC1 1.8716 3.7991 0.533 4.8449
MKN45 GDSC1 1.9292 6.6986 -0.8539 14.9439
RERF-GC-1B GDSC1 1.9366 10.6089 -2.7958 25.3887
23132/87 GDSC1 2.0394 5.8932 -0.3712 11.1848
NUGC-3 GDSC1 2.0843 7.9056 -1.3333 17.5096
OCUM-1 GDSC1 2.2139 5.1239 0.1303 6.9472
MKN28 GDSC1 2.4042 9.5577 -1.9073 19.7315
SCH GDSC1 2.815 4.1368 0.9131 0.6375
SNU-5 GDSC1 2.8528 4.3802 0.8351 0.9547
GCIY GDSC1 2.8645 16.2249 -4.8616 29.3922
TGBC11TKB GDSC1 3.2917 5.8578 0.4403 2.5446
SNU-16 GDSC1 3.6255 4.9209 0.9412 0.1553
Hs 746.T GDSC1 3.6331 5.0407 0.903 0.2259
HSC-39 GDSC1 3.7984 5.3256 0.8641 0.255
NCI-N87 GDSC1 3.8894 5.8311 0.7188 0.611
MKN7 GDSC1 4.0419 5.7224 0.8147 0.2812
SNG-M GDSC1 1.4219 2.4885 0.8438 3.8086
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
B-CPAP GDSC1 0.0758 3.5073 -0.911 22.8676
8305C GDSC1 0.1196 4.1731 -1.1804 24.4017
KMH-2 GDSC1 0.123 2.5994 -0.4548 19.4486
TT2609-C02 GDSC1 0.2394 3.279 -0.6428 20.2189
CAL-62 GDSC1 0.5391 5.6032 -1.4816 24.2773
CGTH-W-1 GDSC1 0.6552 3.0673 -0.1361 14.5621
IHH-4 GDSC1 0.8396 2.2835 0.4139 9.5413
ASH-3 GDSC1 1.0623 4.8022 -0.6175 16.4343
BHT-101 GDSC1 1.1771 5.4368 -0.8353 17.5172
K5 GDSC1 1.5947 10.698 -3.1175 27.783
ML-1 [Human leukemia] GDSC1 1.7747 9.6915 -2.4681 24.5225
HTC-C3 GDSC1 2.9539 10.9942 -2.2048 19.5952
8505C GDSC1 3.4449 13.6982 -3.1725 22.4714
TT GDSC1 3.7147 5.1773 0.8852 0.2372
FTC-133 GDSC1 3.718 5.6494 0.7174 0.7238
WRO GDSC1 5.4488 15.6759 -2.7479 16.0238
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-33 GDSC1 0.1817 4.362 -1.2106 24.2912
KON GDSC1 0.3769 2.5915 -0.1911 16.2723
KOSC-2 GDSC1 0.4491 9.3427 -3.4161 32.9674
HSC-2 GDSC1 0.5716 4.7978 -1.0555 21.5073
Detroit 562 GDSC1 0.6996 3.1145 -0.1162 14.2133
NCI-H3118 GDSC1 0.8732 3.7991 -0.288 14.7699
Ca9-22 GDSC1 1.0313 4.899 -0.6928 17.0961
SCC-15 GDSC1 1.0597 3.6597 -0.0512 12.1994
PCI-06A GDSC1 1.1201 2.237 0.7063 6.0491
UPCI-SCC-090 GDSC1 1.1538 5.8981 -1.0856 19.2829
BHY GDSC1 1.1737 8.1814 -2.2097 25.4938
HSC-4 GDSC1 1.1804 2.7644 0.5007 7.4108
PCI-04B GDSC1 1.3835 7.6954 -1.7907 22.5878
SCC-9 GDSC1 1.393 4.0502 0.0397 10.2298
SCC-4 GDSC1 1.4921 6.9123 -1.3095 19.4168
SCC-25 GDSC1 1.5478 7.5372 -1.5762 20.7941
HO-1-u-1 GDSC1 1.5504 3.7575 0.3132 7.5445
OSC-19 GDSC1 1.6724 4.3792 0.0994 8.8058
JHU-029 GDSC1 1.6739 3.758 0.4087 6.3955
HSC-3 GDSC1 1.6833 7.6845 -1.5397 20.0991
OSC-20 GDSC1 1.7131 5.0196 -0.1873 10.8671
JHU-011 GDSC1 1.7471 9.2725 -2.2811 23.7573
LB771-HNC GDSC1 1.7845 7.6895 -1.461 19.2857
PCI-15A GDSC1 1.8355 3.8851 0.4655 5.4654
BICR 31 GDSC1 1.9268 5.8074 -0.4136 11.8505
HO-1-N-1 GDSC1 1.9641 9.8994 -2.4199 23.6683
FaDu GDSC1 2.3353 4.657 0.4329 4.4025
BB30-HNC GDSC1 2.3494 10.2891 -2.312 21.9241
CAL-27 GDSC1 2.4032 6.1466 -0.2325 9.1019
PE/CA-PJ15 GDSC1 2.4334 4.5197 0.5564 3.3088
BICR 78 GDSC1 2.4743 4.7527 0.4745 3.7934
SKN-3 GDSC1 2.9336 6.255 0.0632 5.6679
BICR 22 GDSC1 3.1052 21.2435 -7.1701 33.5457
PCI-38 GDSC1 3.1261 10.1097 -1.6477 16.201
SAT [Human HNSCC] GDSC1 3.2234 8.3559 -0.7366 10.4167
BB49-HNC GDSC1 3.529 12.599 -2.5734 19.7402
PCI-30 GDSC1 4.0275 5.6568 0.8321 0.2493
JHU-022 GDSC1 4.0805 15.2644 -3.479 22.024
BICR 10 GDSC1 4.1974 22.5883 -6.995 30.9406
SAS GDSC1 4.35 11.9354 -1.695 13.3851
DOK GDSC1 4.554 16.541 -3.7645 21.9315
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-112 GDSC1 0.0009 1.3596 -0.1238 17.7587
SW1710 GDSC1 0.6241 2.9008 -0.0872 14.3333
BFTC-905 GDSC1 1.2203 2.4923 0.6712 5.9147
5637 GDSC1 1.2487 5.9741 -1.043 18.6376
639V GDSC1 1.2897 14.7967 -5.4196 35.0035
J82 GDSC1 1.3805 10.1139 -3.0025 28.0909
SW780 GDSC1 1.71 6.7802 -1.0669 17.1038
647V GDSC1 1.717 5.9746 -0.6597 14.3169
CAL-29 GDSC1 2.217 5.7242 -0.1587 9.0894
KU-19-19 GDSC1 2.5897 5.1478 0.3631 4.3255
HT-1376 GDSC1 2.9518 8.6013 -1.0382 13.0676
HT-1197 GDSC1 3.0755 4.4435 0.9052 0.4768
RT-4 GDSC1 3.1993 6.5791 0.0738 5.0383
UM-UC-3 GDSC1 3.4623 6.9119 0.075 4.5267
TCCSUP GDSC1 4.0529 5.9794 0.7284 0.4944
T24 GDSC1 5.9209 18.2172 -3.6411 18.5799
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1 0.1995 7.9318 -2.9392 32.4302
PA-1 GDSC1 0.6563 6.8706 -2.004 26.5694
LB831-BLC GDSC1 0.7359 5.2031 -1.1059 21.1214
SW954 GDSC1 0.7975 4.1879 -0.5486 17.0211
CAL-39 GDSC1 0.9484 3.2024 0.0745 11.6804
SiSo GDSC1 1.1411 5.2976 -0.7965 17.3896
NT2-D1 GDSC1 1.1834 11.5071 -3.864 31.6308
NCC-IT GDSC1 1.2066 3.0582 0.3775 8.276
NEC8 GDSC1 1.3028 2.7207 0.6289 5.9316
OVMIU GDSC1 1.5883 4.9931 -0.2727 11.9344
C-4-I GDSC1 1.6475 7.3322 -1.3927 19.3605
HeLa GDSC1 1.6909 3.6571 0.4713 5.8546
MS751 GDSC1 1.7662 3.2371 0.7316 3.6239
SW962 GDSC1 1.802 7.9161 -1.5601 19.8022
Ca Ski GDSC1 1.867 6.1523 -0.6307 13.6057
HEC-1 GDSC1 1.916 11.4104 -3.2124 27.074
C-33 A GDSC1 2.0862 11.6136 -3.1776 26.4047
SKN GDSC1 2.1294 4.2325 0.5001 4.4097
DSH1 GDSC1 2.1296 4.5278 0.3594 5.4572
JEG-3 GDSC1 2.1702 3.5178 0.8547 1.8034
SW756 GDSC1 2.2643 3.9703 0.7059 2.624
DoTc2 4510 GDSC1 2.5554 10.1273 -2.0745 20.1261
HT-3 GDSC1 2.6228 19.0006 -6.4339 33.3874
KGN GDSC1 2.8479 5.1384 0.5158 2.792
SiHa GDSC1 2.8858 4.7361 0.7066 1.5858
SKG-IIIa GDSC1 3.089 11.1915 -2.2028 19.2022
ME-180 GDSC1 3.639 6.3033 0.4268 2.1438
JAR GDSC1 3.7318 5.8015 0.6661 0.9093
OMC-1 [Human cervical carcinoma] GDSC1 4.7684 6.6757 0.746 0.2108
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT00666926) Study Of PF-00562271, Including Patients With Pancreatic, Head And Neck, Prostatic Neoplasms. U.S. National Institutes of Health.
2 Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther. 2011 Nov;10(11):2135-45.