Details of the Drug

General Information of Drug (ID: DMT4QHD)

Drug Name
GDC-0032
Synonyms
Taselisib; 1282512-48-4; GDC 0032; UNII-L08J2O299M; 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide; CHEMBL2387080; GDC0032; L08J2O299M; Taselisib [INN]; 2-Methyl-2-(4-{2-[3-Methyl-1-(Propan-2-Yl)-1h-1,2,4-Triazol-5-Yl]-5,6-Dihydroimidazo[1,2-D][1,4]benzoxazepin-9-Yl}-1h-Pyrazol-1-Yl)propanamide; Taselisib [USAN:INN]; GTPL7794; SCHEMBL1485247; SYN1202; DTXSID00155842; BEUQXVWXFDOSAQ-UHFFFAOYSA-N
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 3 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2/3 [2]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 460.5
Logarithm of the Partition Coefficient (xlogp) 1.8
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C24H28N8O2
IUPAC Name
2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide
Canonical SMILES
CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C
InChI
InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)
InChIKey
BEUQXVWXFDOSAQ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
51001932
CAS Number
1282512-48-4
UNII
L08J2O299M
DrugBank ID
DB12108
TTD ID
D0UP1Z
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase alpha (PIK3CA) TTEUNMR PK3CA_HUMAN Modulator [3]
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Breast cancer
ICD Disease Classification 2C60-2C65
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PI3-kinase gamma (PIK3CG) DTT PIK3CG 1.98E-01 -0.05 -0.55
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 3.4976 6.6915 1.7812 8.4061
EW-12 GDSC2 -2.966 3.3789 -3.5559 59.0595
EW-7 GDSC2 -2.0769 3.1501 -2.524 48.203
HuO9 GDSC2 -1.0352 7.1391 -2.83 42.747
ES5 GDSC2 -0.8736 6.2761 -2.3016 41.0963
EW-11 GDSC2 -0.5585 8.0107 -2.7174 40.4304
ES1 GDSC2 -0.4978 8.6656 -2.9498 41.3333
ES8 GDSC2 0.0933 5.8559 -1.113 33.506
EW-1 GDSC2 0.6655 7.4457 -1.2255 31.5574
G-292 clone A141B1 GDSC2 0.7753 8.4367 -1.5773 32.2884
CHSA8926 GDSC2 0.9382 5.5907 -0.1207 26.1125
EW-18 GDSC2 0.9743 9.5132 -1.8963 32.524
SK-ES-1 GDSC2 1.0071 8.6979 -1.4752 31.1133
EW-22 GDSC2 1.052 8.1147 -1.1551 29.8621
EW-24 GDSC2 1.0871 10.3201 -2.1782 32.921
SaOS-2 GDSC2 1.3017 12.2135 -2.9023 34.0207
MG-63 GDSC2 1.5696 7.2467 -0.2407 24.3573
EW-3 GDSC2 1.6524 12.8082 -2.8755 32.877
NOS-1 [Human HNSCC] GDSC2 1.8417 11.6266 -2.1204 30.3101
CHSA0108 GDSC2 2.0719 15.7134 -3.9441 36.0856
ES6 GDSC2 2.2752 12.779 -2.3049 29.5461
H-EMC-SS GDSC2 2.5546 10.6793 -1.0143 24.4321
SK-PN-DW GDSC2 2.6502 7.4775 0.6608 16.5396
SJSA-1 GDSC2 2.8615 10.6499 -0.7324 22.9471
ES7 GDSC2 3.0143 8.2286 0.6077 15.776
TC-71 GDSC2 3.1368 9.3363 0.1591 17.6767
CHSA0011 GDSC2 3.2543 10.0669 -0.1071 20.6556
A-673 GDSC2 3.4098 9.777 0.1673 16.9078
EW-13 GDSC2 3.5414 9.1319 0.5977 14.4304
ES4 GDSC2 3.6706 10.4084 0.0649 16.7267
HOS GDSC2 3.6991 9.7277 0.4277 14.8924
CAL-72 GDSC2 3.9497 6.8602 2.0448 5.6788
HuO-3N1 GDSC2 4.0318 11.562 -0.2225 17.1615
CAL-78 GDSC2 4.4406 8.2516 1.7156 6.4698
EW-16 GDSC2 4.7145 16.7072 -2.2485 23.2225
U-CH2 GDSC2 4.9712 12.6448 -0.0466 15.7472
MHH-ES-1 GDSC2 5.033 15.7734 -1.5417 20.1682
CADO-ES1 GDSC2 5.5003 7.0614 2.8131 0.2868
U2OS GDSC2 6.957 16.4776 -0.5292 12.5821
NY GDSC2 7.3032 18.396 -1.2112 14.6354
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 165 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC2 4.3593 6.2976 2.5839 2.3804
SU-DHL-6 GDSC2 -7.1507 -4.0988 -7.1522 87.3479
NCI-H929 GDSC2 -5.555 -1.8445 -5.5725 75.5068
RCH-ACV GDSC2 -5.4955 16.2438 -11.4222 59.3802
WSU-NHL GDSC2 -5.3847 -0.4085 -5.4796 71.9924
SUP-B8 GDSC2 -4.4752 8.8949 -7.1628 60.7951
Kasumi-1 GDSC2 -3.3734 7.3829 -5.3889 54.8328
GDM-1 GDSC2 -3.217 5.4944 -4.5065 54.8403
NU-DUL-1 GDSC2 -3.0724 8.5953 -5.5679 56.1692
HAL-01 GDSC2 -3.0174 7.6636 -5.1253 53.2204
MM1.S GDSC2 -2.9764 -0.4265 -2.9866 55.7084
NALM-6 GDSC2 -2.8154 12.379 -6.9693 51.6918
Farage GDSC2 -2.7758 4.411 -3.6591 52.8055
A4/Fukuda GDSC2 -2.4073 4.9498 -3.4402 50.5222
MOLP-8 GDSC2 -2.355 3.992 -3.0686 50.2226
SU-DHL-5 GDSC2 -2.3384 0.2737 -2.3586 50.1466
BONNA-12 GDSC2 -2.3245 9.1022 -5.008 52.9648
SU-DHL-16 GDSC2 -2.2034 1.1599 -2.2841 55.0348
KMS-11 GDSC2 -1.8764 9.9149 -4.9076 50.9388
MC116 GDSC2 -1.6943 1.8199 -1.8276 50.3097
PL-21 GDSC2 -1.5992 6.4484 -3.1371 49.6356
ARH-77 GDSC2 -1.5634 8.3964 -3.917 46.2925
RPMI-8402 GDSC2 -1.55 5.4595 -2.7006 46.1309
NB4 GDSC2 -1.4424 5.5233 -2.6094 48.5639
TALL-1 [Human adult T-ALL] GDSC2 -1.2328 8.7027 -3.7124 47.8493
HT GDSC2 -0.5501 11.4198 -4.2784 45.2451
MLMA GDSC2 -0.5435 17.8704 -7.3804 44.9046
RPMI-8866 GDSC2 -0.5431 7.545 -2.4961 39.9524
Karpas-1106P GDSC2 -0.4928 10.2968 -3.6953 41.6655
Namalwa GDSC2 -0.4149 11.2441 -4.0636 41.8446
OCI-AML-5 GDSC2 -0.388 7.3551 -2.2537 38.7752
Mono-Mac-6 GDSC2 -0.3879 6.704 -1.9721 38.9788
WSU-DLCL2 GDSC2 -0.3361 2.2904 -0.4433 33.8366
Karpas-620 GDSC2 -0.2506 5.8764 -1.4825 36.2002
ML-2 GDSC2 -0.2356 9.9531 -3.2813 40.0812
SKM-1 GDSC2 -0.1501 11.0379 -3.7083 40.4193
DoHH2 GDSC2 -0.1029 1.6017 -0.1215 30.4259
JVM-2 GDSC2 0.0407 13.5417 -4.7267 41.1012
MHH-CALL-4 GDSC2 0.1074 11.6052 -3.7301 42.198
KY821 GDSC2 0.1446 14.5312 -5.1097 41.2131
TUR GDSC2 0.1859 3.4757 -0.1437 29.2676
ATN-1 GDSC2 0.2197 10.8266 -3.2499 38.3529
THP-1 GDSC2 0.2286 13.9254 -4.7362 42.8496
Loucy GDSC2 0.3235 6.7132 -1.2422 32.9751
RPMI-6666 GDSC2 0.325 19.4952 -7.3805 42.7208
GA-10 GDSC2 0.4581 17.8322 -6.4391 41.6426
L-363 GDSC2 0.6269 9.8747 -2.403 35.1126
OCI-AML-3 GDSC2 0.6337 10.359 -2.6283 35.6194
OPM-2 GDSC2 0.6947 3.4643 0.4147 24.5744
MOLM-16 GDSC2 0.7694 9.6099 -2.1394 36.8534
NK-92MI GDSC2 0.8478 12.2173 -3.325 38.9114
P31/FUJ GDSC2 0.8747 6.1523 -0.4308 28.4481
KE-37 GDSC2 0.9571 5.9627 -0.2629 26.6735
AMO1 GDSC2 1.0087 10.5603 -2.3686 33.6897
MOLT-16 GDSC2 1.0386 5.5495 0.001 25.176
Karpas-422 GDSC2 1.0612 8.6868 -1.4176 30.7297
MOLM-13 GDSC2 1.0681 8.3376 -1.2449 30.119
SU-DHL-10 GDSC2 1.0846 3.0235 0.9549 20.4177
Jurkat GDSC2 1.345 5.6224 0.2843 22.7025
P32/ISH GDSC2 1.4286 7.4081 -0.4542 25.7775
VL51 GDSC2 1.4444 10.9776 -2.1646 31.6939
Reh GDSC2 1.4867 10.3189 -1.8031 30.4956
MV4-11 GDSC2 1.4903 14.8648 -4.039 35.7548
GR-ST GDSC2 1.5597 7.9807 -0.6006 25.9363
CESS GDSC2 1.6864 8.2406 -0.6051 25.525
P12-Ichikawa GDSC2 1.843 9.1293 -0.8907 26.1534
Jiyoye GDSC2 1.8963 8.9344 -0.7459 25.4069
Karpas-45 GDSC2 1.9064 8.0805 -0.3199 23.5769
P30/OHK GDSC2 1.9158 15.5105 -3.9805 34.47
NOMO-1 GDSC2 1.9384 10.0663 -1.2628 27.2366
OCI-Ly7 GDSC2 1.993 16.4872 -4.3985 37.063
ALL-PO GDSC2 2.168 13.4452 -2.7309 31.0053
PF-382 GDSC2 2.1922 12.6468 -2.3125 29.8084
Daudi GDSC2 2.213 8.1399 -0.0639 21.4366
KMS-12-BM GDSC2 2.3033 10.6654 -1.2298 25.9881
697 GDSC2 2.3217 15.9063 -3.8221 33.0767
SUP-HD1 GDSC2 2.3303 7.1791 0.5153 18.2513
CCRF-CEM GDSC2 2.3369 6.7871 0.7127 17.2169
SU-DHL-4 GDSC2 2.3404 5.1212 1.5142 14.6495
JeKo-1 GDSC2 2.4013 13.6072 -2.6067 32.2777
WIL2 NS GDSC2 2.4299 7.2747 0.5605 17.715
CRO-AP2 GDSC2 2.487 9.0885 -0.2836 23.967
BC-1 GDSC2 2.5003 10.2069 -0.8271 23.8578
RS4;11 GDSC2 2.5808 14.8632 -3.0774 30.7303
EoL-1 GDSC2 2.7086 9.2473 -0.1663 20.4123
U-698-M GDSC2 2.7316 9.1077 -0.0765 19.9319
HL-60 GDSC2 2.7317 11.2849 -1.1615 24.4779
SR GDSC2 2.8998 9.6819 -0.2163 20.0915
NKM-1 GDSC2 2.9764 13.5789 -2.0973 27.4862
BC-3 GDSC2 3.1024 6.8847 1.3545 13.0502
SU-DHL-1 GDSC2 3.117 9.7192 -0.0491 20.7975
RL GDSC2 3.1661 9.8874 -0.0916 20.8513
SUP-T1 GDSC2 3.1853 16.6966 -3.4796 30.1396
RPMI-8226 GDSC2 3.2439 7.6537 1.0906 12.6078
Karpas-299 GDSC2 3.4236 11.0838 -0.4746 20.2754
MOLT-4 GDSC2 3.444 8.6113 0.7783 13.7462
YT GDSC2 3.4628 10.6706 -0.2357 19.1055
SUP-M2 GDSC2 3.4864 5.8014 2.2165 5.7697
OCI-AML-2 GDSC2 3.4939 8.0486 1.1003 11.9116
VAL GDSC2 3.5546 16.8689 -3.2586 28.716
MHH-PREB-1 GDSC2 3.5759 7.6154 1.383 10.1732
A3/Kawakami GDSC2 3.5963 5.3074 2.5475 3.6737
JURL-MK1 GDSC2 3.6492 5.2118 2.634 3.0825
DB GDSC2 3.6528 5.3083 2.5891 3.3213
OCI-M1 GDSC2 3.6642 6.0508 2.2312 5.2729
SIG-M5 GDSC2 3.6677 8.039 1.245 12.0667
ST486 GDSC2 3.6726 6.4915 2.0191 6.4297
CA46 GDSC2 3.6947 9.8105 0.3828 15.1265
BALL-1 GDSC2 3.76 12.4981 -0.9064 20.7348
Ramos.2G6.4C10 GDSC2 3.7666 6.1752 2.2468 4.9602
BL-41 GDSC2 3.7865 5.6483 2.5195 3.4246
L-540 GDSC2 3.8068 8.0409 1.3533 9.7831
MY-M12 GDSC2 3.8156 6.0791 2.33 4.9821
KG-1 GDSC2 3.8416 5.6723 2.5466 3.1677
JVM-3 GDSC2 3.8837 20.9363 -5.0216 31.6995
L-428 GDSC2 3.9114 6.1497 2.3641 4.0173
SCC-3 GDSC2 3.9407 6.9687 1.985 6.0247
EB2 GDSC2 3.9527 21.2271 -5.1106 31.714
L-1236 GDSC2 3.9532 15.5858 -2.2922 25.1043
Raji GDSC2 3.9892 6.1023 2.4408 3.453
BV-173 GDSC2 3.9899 6.3282 2.3325 4.0333
RC-K8 GDSC2 3.9968 9.5856 0.7332 12.6249
OCI-Ly19 GDSC2 4.0169 12.1485 -0.5264 20.3915
KCL-22 GDSC2 4.0524 9.6152 0.7614 12.3504
MOLT-13 GDSC2 4.0612 6.8511 2.1291 4.9918
SU-DHL-8 GDSC2 4.0844 5.4693 2.7974 1.4578
DG-75 GDSC2 4.1456 8.651 1.3088 9.2579
IM-9 GDSC2 4.1587 7.7608 1.7553 6.8199
LP-1 GDSC2 4.17 7.2167 2.028 5.3221
JSC-1 GDSC2 4.2423 10.8132 0.3129 14.1572
HC-1 GDSC2 4.2425 15.8728 -2.2038 24.1512
BE-13 GDSC2 4.2601 5.9353 2.6895 1.7315
U266B1 GDSC2 4.2942 6.149 2.613 2.0541
K-562 GDSC2 4.2963 6.2981 2.5461 2.3815
EM-2 GDSC2 4.3097 7.895 1.7971 6.2894
JJN-3 GDSC2 4.3238 9.682 0.9333 10.851
CTV-1 GDSC2 4.3403 11.3094 0.1419 14.7532
DND-41 GDSC2 4.3508 6.8678 2.3156 3.4674
LAMA-84 GDSC2 4.3582 6.9837 2.2659 3.7127
Hs 445 GDSC2 4.4046 10.1898 0.7432 11.6511
LC4-1 GDSC2 4.4428 6.8145 2.3978 2.8983
SUP-B15 GDSC2 4.5179 5.9845 2.8058 0.9116
HDLM-2 GDSC2 4.526 7.6788 2.0467 4.5635
KMOE-2 GDSC2 4.5285 11.8741 0.005 14.9681
EJM GDSC2 4.5366 11.525 0.1834 14.1142
QIMR-WIL GDSC2 4.5605 11.558 0.185 15.604
CTB-1 GDSC2 4.6042 18.3876 -3.1708 27.8355
MEG-01 GDSC2 4.6203 7.0925 2.3773 2.7325
MN-60 GDSC2 4.6262 8.7749 1.591 6.7747
KOPN-8 GDSC2 4.7865 13.2786 -0.4948 16.6171
CML-T1 GDSC2 4.8139 6.5987 2.6966 1.0642
DEL GDSC2 4.8479 8.9766 1.6428 6.0977
Ku812 GDSC2 4.95 8.0026 2.1589 3.3205
ME1 GDSC2 4.9684 5.8945 3.0255 0.0744
Karpas-231 GDSC2 5.0059 6.3041 2.8955 0.2944
ALL-SIL GDSC2 5.0477 15.9111 -1.5986 20.3384
SK-MM-2 GDSC2 5.0615 15.8222 -1.5443 20.1163
H9 GDSC2 5.1004 13.8357 -0.5365 16.1172
MHH-CALL-2 GDSC2 5.122 14.8259 -1.0075 17.984
ROS-50 GDSC2 5.1702 9.4531 1.6257 6.3596
Granta-519 GDSC2 5.3551 7.6237 2.5366 1.195
HEL GDSC2 5.5729 6.8229 2.9222 0.0955
TK [Human B-cell lymphoma] GDSC2 5.7255 7.3021 2.8121 0.2193
KM-H2 GDSC2 5.818 13.7446 0.0155 12.2799
HH [Human lymphoma] GDSC2 6.0662 22.7228 -4.1972 25.6918
⏷ Show the Full List of 165 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACP4 C GDSC2 -1.4339 5.4793 -2.5837 44.3971
SK-GT-4 GDSC2 0.0189 8.2948 -2.2616 37.0891
KYSE-220 GDSC2 0.6674 6.5612 -0.8236 30.0971
OACM5.1 C GDSC2 1.7638 9.2509 -1.0237 26.9217
TE-12 GDSC2 2.2044 12.9819 -2.4683 30.2059
KYAE-1 GDSC2 2.359 8.7218 -0.2172 21.6867
ESO-26 GDSC2 3.6094 10.5871 -0.074 17.5321
KYSE-50 GDSC2 3.7364 8.6934 0.9733 11.9911
FLO-1 GDSC2 3.7412 11.0496 -0.1983 17.768
ESO-51 GDSC2 3.8231 6.8737 1.9444 6.503
HCE-4 GDSC2 3.9926 11.8427 -0.3933 19.8622
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 1.7283 8.9572 -0.9134 26.618
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-12 GDSC2 -1.1057 4.9491 -2.0351 42.7322
NB1 GDSC2 -0.9858 7.2809 -2.8389 43.3666
NB69 GDSC2 -0.6797 9.4915 -3.5089 42.1475
NB(TU)1 GDSC2 0.1065 9.6819 -2.8179 37.9493
CHP-212 GDSC2 0.4796 12.2102 -3.6674 38.1894
SK-N-SH GDSC2 1.6602 10.0938 -1.5321 29.6837
SK-N-MC-IXC GDSC2 1.6866 7.6016 -0.2972 26.9612
LA-N-6 GDSC2 1.9067 8.4215 -0.4857 26.9449
SK-N-FI GDSC2 2.147 10.9376 -1.5045 28.0118
SJNB-10 GDSC2 2.3812 8.1105 0.1046 20.1216
KP-N-RT-BM-1 GDSC2 2.5208 5.0535 1.7229 12.7182
SJNB-6 GDSC2 2.5374 9.6171 -0.5012 24.768
MHH-NB-11 GDSC2 2.6146 10.9666 -1.1047 26.9523
SK-N-BE(2)-M17 GDSC2 2.9 7.1332 1.0542 13.7423
NH-12 GDSC2 2.9503 14.7995 -2.7294 28.8637
SK-N-DZ GDSC2 3.2307 9.5151 0.149 17.4712
SJNB-17 GDSC2 3.2681 8.8662 0.5048 17.4761
SiMa GDSC2 3.3347 12.4104 -1.2117 23.0102
GOTO GDSC2 3.3471 5.4437 2.2819 5.7492
TGW GDSC2 3.526 11.948 -0.8223 20.994
CHP-134 GDSC2 3.5801 6.0483 2.1675 5.8199
IMR-5 GDSC2 3.6858 6.1719 2.1876 5.4655
SJNB-14 GDSC2 3.6986 10.6541 -0.0352 17.126
SJNB-5 GDSC2 3.7947 13.6108 -1.434 24.6281
KP-N-YS GDSC2 3.8748 9.6901 0.5861 15.2852
SJNB-7 GDSC2 3.9045 5.4985 2.6724 2.3794
CHP-126 GDSC2 4.2542 8.5686 1.4292 9.4541
KP-N-YN GDSC2 4.4437 14.5449 -1.3843 20.9143
Kelly GDSC2 4.5429 8.0098 1.9008 5.2971
SJNB-13 GDSC2 5.3892 14.1486 -0.4802 15.2803
GI-ME-N GDSC2 7.0547 21.3938 -2.8238 20.358
SK-N-AS GDSC2 8.3643 21.2203 -1.8549 15.178
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 3.6459 11.4662 -0.4834 19.2694
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UACC-893 GDSC2 -3.7681 -0.373 -3.7992 68.8688
MDA-MB-361 GDSC2 -3.3106 2.4954 -3.7085 56.8803
OCUB-M GDSC2 -3.037 -1.4509 -3.0372 56.3329
MDA-MB-453 GDSC2 -2.9078 5.1149 -4.0389 53.3644
MDA-MB-330 GDSC2 -2.8444 2.3125 -3.1613 53.8604
CAL-148 GDSC2 -2.1991 1.8117 -2.3684 50.3183
HCC1954 GDSC2 -1.7866 5.7142 -3.05 46.7871
BT-20 GDSC2 -1.3691 5.0703 -2.3626 43.7334
MDA-MB-175-VII GDSC2 -0.8995 4.8669 -1.7832 41.1002
HDQ-P1 GDSC2 -0.1015 5.5201 -1.1807 34.5868
HCC1569 GDSC2 0.1654 6.956 -1.5111 34.4836
HCC2157 GDSC2 0.4406 3.5493 0.1126 27.0321
CAL-51 GDSC2 0.5696 4.6332 -0.1195 27.559
MFM-223 GDSC2 0.6058 6.2066 -0.7303 29.9806
T-47D GDSC2 0.7795 16.9278 -5.7008 40.0683
Evsa-T GDSC2 0.9578 3.3786 0.7262 22.0223
EFM-19 GDSC2 1.1305 16.0939 -4.9711 38.2191
CAL-85-1 GDSC2 1.2529 7.948 -0.8807 28.1248
BT-474 GDSC2 1.2554 11.0349 -2.3681 32.8622
EFM-192A GDSC2 1.2656 9.5215 -1.6229 30.6775
JIMT-1 GDSC2 1.4692 10.6002 -1.9569 31.016
YMB-1-E GDSC2 1.5498 5.3236 0.6257 22.8912
Hs 578T GDSC2 1.8124 9.2959 -1.0006 26.6752
UACC-812 GDSC2 1.8952 8.7154 -0.6398 25.5874
HCC70 GDSC2 1.9117 5.5035 0.9113 17.559
MDA-MB-415 GDSC2 2.0946 5.1809 1.2421 15.2047
HCC1599 GDSC2 2.194 11.7875 -1.884 30.8892
HCC1806 GDSC2 2.3422 7.5718 0.334 19.1243
MCF-7 GDSC2 2.9547 11.06 -0.8572 22.6701
CAL-120 GDSC2 2.9582 5.8938 1.7216 9.9222
COLO 824 GDSC2 2.9758 13.1959 -1.9064 26.3802
AU565 GDSC2 3.0032 15.4739 -3.0217 29.4874
CAMA-1 GDSC2 3.0342 6.0449 1.7138 9.7522
MDA-MB-468 GDSC2 3.0683 6.6014 1.4663 11.0279
MRK-nu-1 GDSC2 3.2852 4.9832 2.4605 4.9102
HCC1395 GDSC2 3.337 9.8717 0.0596 18.0643
HCC1937 GDSC2 3.3507 9.1549 0.4294 15.7747
HCC1143 GDSC2 3.4219 12.8482 -1.3582 23.3215
DU4475 GDSC2 3.8349 5.4412 2.6533 2.6077
MDA-MB-231 GDSC2 4.0488 7.6062 1.7512 7.0728
MDA-MB-436 GDSC2 4.2423 9.2641 1.0786 10.2694
HCC2218 GDSC2 4.2436 9.8095 0.8105 13.0296
HCC1500 GDSC2 4.3053 8.3802 1.5581 7.5819
BT-549 GDSC2 4.4333 12.1208 -0.1891 16.0689
ZR-75-30 GDSC2 4.5663 15.9051 -1.9651 22.6466
HCC1428 GDSC2 4.7585 6.507 2.7075 1.0733
HCC1187 GDSC2 5.3882 13.156 0.0023 13.1673
HCC38 GDSC2 5.4737 14.1748 -0.4326 14.9072
HCC1419 GDSC2 6.5296 15.3923 -0.2949 12.345
MDA-MB-157 GDSC2 6.6322 15.5064 -0.2817 12.112
BT-483 GDSC2 8.3215 22.7868 -2.6254 17.9565
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-336MG GDSC2 0.4785 7.6973 -1.5279 36.5421
YH-13 GDSC2 0.4904 6.8325 -1.1246 31.8981
D-247MG GDSC2 0.9144 7.3593 -0.9376 32.738
PFSK-1 GDSC2 1.4952 12.8938 -3.0603 33.7807
SW1783 GDSC2 1.5692 5.3839 0.6188 20.8261
SF126 GDSC2 1.5717 7.6231 -0.4178 27.9456
SW1088 GDSC2 2.0037 6.3211 0.6196 18.7599
GaMG GDSC2 2.006 6.6313 0.474 19.491
42-MG-BA GDSC2 2.0639 11.1645 -1.6915 28.3083
T98G GDSC2 2.105 6.8464 0.4653 19.2141
MOG-G-UVW GDSC2 2.1476 4.9931 1.3809 14.71
Hs 683 GDSC2 2.1672 6.199 0.8358 19.3033
GI-1 GDSC2 2.2675 7.9574 0.0759 20.6094
SF539 GDSC2 2.2916 8.506 -0.1719 21.6885
Becker GDSC2 2.3261 7.6672 0.2723 19.4778
H4 GDSC2 2.356 7.1517 0.5526 17.9818
D-566MG GDSC2 2.4356 7.5685 0.4213 20.6396
SNB-75 GDSC2 2.5817 9.9873 -0.6461 25.2395
U-87MG ATCC GDSC2 2.5857 6.6175 1.0266 14.803
KS-1 [Human Krukenberg tumour] GDSC2 2.7057 9.9498 -0.5186 21.9784
8-MG-BA GDSC2 2.7689 10.619 -0.7972 22.954
SF295 GDSC2 2.9947 5.1526 2.1214 8.6088
D-502MG GDSC2 3.03 9.3009 0.0858 20.4042
D-245MG GDSC2 3.1496 8.7068 0.4846 17.9491
LNZTA3WT4 GDSC2 3.1616 6.9235 1.3859 12.6761
D-542MG GDSC2 3.2149 13.9852 -2.0992 28.457
LN-405 GDSC2 3.3135 7.9255 1.0131 12.8418
U-118MG GDSC2 3.3271 6.1142 1.9301 7.7653
LN-18 GDSC2 3.3441 7.7764 1.1132 12.2244
D-423MG GDSC2 3.405 8.4553 0.8241 15.2853
M059J GDSC2 3.5656 8.0796 1.143 11.5027
SK-MG-1 GDSC2 3.5759 16.2496 -2.9315 27.8282
A-172 GDSC2 3.6106 9.603 0.4186 15.1592
CAS-1 GDSC2 3.6155 8.6982 0.8744 12.8098
D-263MG GDSC2 3.6747 6.8819 1.8267 7.4913
SF268 GDSC2 3.692 12.984 -1.2043 22.0601
KNS-81-FD GDSC2 3.6978 6.8804 1.8454 8.3
MOG-G-CCM GDSC2 3.7771 9.1164 0.7947 13.1819
ONS-76 GDSC2 3.9745 6.2138 2.3771 3.8227
U-251MG GDSC2 3.9906 7.6459 1.6888 7.5386
Onda 10 GDSC2 4.0851 8.135 1.518 9.3306
GB-1 GDSC2 4.1553 10.453 0.4249 13.8102
NMC-G1 GDSC2 4.288 10.6912 0.4082 15.1442
AM-38 GDSC2 4.384 7.5531 2.0126 4.9975
KALS-1 GDSC2 4.4615 12.6947 -0.4519 17.1622
Onda 11 GDSC2 4.4805 14.059 -1.1143 21.6113
Daoy GDSC2 4.4851 11.8714 -0.0264 15.2105
DK-MG GDSC2 4.5575 10.0038 0.9464 10.2841
LN-229 GDSC2 4.6287 6.8512 2.4906 2.1754
DBTRG-05MG GDSC2 4.6508 9.3954 1.3087 8.2104
D-392MG GDSC2 4.9287 12.8017 -0.1547 14.8214
KNS-42 GDSC2 5.009 11.8987 0.3452 13.7148
D283 Med GDSC2 5.1836 18.0692 -2.5635 23.1734
KINGS-1 GDSC2 5.2648 16.8734 -1.9106 20.9474
YKG-1 GDSC2 6.3685 14.6024 -0.0262 12.6548
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 -1.6031 4.0731 -2.2753 44.9342
ETK-1 GDSC2 1.0501 6.5186 -0.4166 26.9875
TGBC1TKB GDSC2 2.8396 5.5885 1.7652 10.3165
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC2 -0.7137 6.7852 -2.3455 40.427
MFE-280 GDSC2 -0.0019 10.2607 -3.1964 39.0616
ESS-1 GDSC2 0.7495 10.7732 -2.717 35.4169
EN GDSC2 2.5728 10.8305 -1.0736 24.6054
KLE GDSC2 2.7866 9.6499 -0.2985 20.7837
RL95-2 GDSC2 3.537 6.0593 2.1281 6.1413
MFE-319 GDSC2 4.0183 7.6689 1.6979 7.4287
MFE-296 GDSC2 4.0605 8.0189 1.5569 8.1046
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-54 GDSC2 0.4092 7.2927 -1.4135 33.1859
KTCTL-26A GDSC2 1.0789 4.8993 0.3163 26.5475
KTCTL-13 GDSC2 1.1268 7.5278 -0.8059 31.3427
BFTC-909 GDSC2 1.3937 12.118 -2.7709 33.4239
KTCTL-140 GDSC2 1.4047 6.3181 0.0308 26.5703
LB996-RCC GDSC2 1.5796 6.0898 0.3103 21.7419
NCC021 GDSC2 1.8502 7.6707 -0.1744 25.7675
LB1047-RCC GDSC2 2.235 13.1702 -2.535 32.6138
KTCTL-195 GDSC2 2.4624 7.6824 0.3896 18.4804
UO-31 GDSC2 2.5264 8.1954 0.1941 21.5143
Caki-1 GDSC2 2.831 10.8135 -0.8404 25.224
ACHN GDSC2 2.8519 7.95 0.6054 16.243
A-498 GDSC2 2.8637 7.7747 0.703 15.7048
KTCTL-21 GDSC2 2.884 9.9385 -0.358 22.9885
HA7-RCC GDSC2 3.1302 7.1249 1.2584 12.0004
KTCTL-1M GDSC2 3.1525 7.6959 0.9922 15.07
KMRC-1 GDSC2 3.2959 7.0825 1.4199 10.9857
786-O GDSC2 3.3203 7.3034 1.3298 11.1081
LB2241-RCC GDSC2 3.3427 10.2604 -0.1301 20.4981
OS-RC-2 GDSC2 3.38 7.2096 1.4262 10.4257
A-704 GDSC2 3.3863 10.9837 -0.4555 19.8224
SW156 GDSC2 3.4198 5.7062 2.2103 6.7581
TK-10 GDSC2 3.4627 9.7 0.2494 16.3723
RXF 393L GDSC2 3.4798 8.5792 0.8236 13.4175
SW13 GDSC2 4.0371 11.8821 -0.3777 17.8383
SN12C GDSC2 4.1643 8.1074 1.5898 7.7047
BB65-RCC GDSC2 4.2702 7.4512 1.9842 6.07
RCC10RGB GDSC2 4.434 13.0056 -0.6272 17.9701
769-P GDSC2 4.5769 13.1932 -0.6108 17.5751
VMRC-RCW GDSC2 4.704 11.0227 0.5538 13.3414
KMRC-20 GDSC2 4.7991 9.8228 1.205 8.4603
VMRC-RCZ GDSC2 4.8384 8.2948 1.9571 4.4983
NCC010 GDSC2 4.9019 11.3603 0.5313 11.656
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H508 GDSC2 -2.3198 7.7667 -4.4346 53.1819
DiFi GDSC2 -0.7841 7.1216 -2.5616 41.153
SW948 GDSC2 -0.1871 5.8487 -1.4043 35.6804
GP5d GDSC2 -0.1651 8.9107 -2.728 38.8245
SW48 GDSC2 -0.1004 11.1783 -3.7268 40.2685
SK-CO-1 GDSC2 0.2076 7.5877 -1.7504 35.0095
HT-29 GDSC2 0.593 9.3586 -2.1904 34.7041
CaR-1 GDSC2 0.7521 5.8612 -0.4296 28.1817
LS513 GDSC2 0.8748 7.9772 -1.2641 30.8946
SNU-C1 GDSC2 0.9102 6.3023 -0.4611 27.7035
HT-55 GDSC2 0.9619 8.1005 -1.2366 30.4775
CCK-81 GDSC2 1.0027 7.0452 -0.7047 28.3501
SNU-407 GDSC2 1.0935 11.9557 -2.9684 34.8322
LoVo GDSC2 1.1221 8.0373 -1.0503 29.23
T84 GDSC2 1.2798 7.6657 -0.721 27.4039
C2BBe1 GDSC2 1.3549 5.2172 0.4712 21.7518
SNU-C5 GDSC2 1.3746 9.7386 -1.6253 30.313
COLO 320HSR GDSC2 1.413 11.026 -2.2173 31.942
NCI-H747 GDSC2 1.6799 11.157 -2.0361 30.5701
HCT 15 GDSC2 1.8675 11.4886 -2.0289 29.9619
LS180 GDSC2 1.9507 9.5963 -1.0204 26.3042
LS123 GDSC2 2.1503 10.8229 -1.4448 27.2166
SNU-283 GDSC2 2.2638 15.1003 -3.4707 34.6381
SNU-175 GDSC2 2.2943 13.3373 -2.566 30.2129
HCC2998 GDSC2 2.4408 8.1213 0.1534 19.7057
LS411N GDSC2 2.6166 6.2611 1.2298 13.6156
SNU-81 GDSC2 2.8297 7.7287 0.6959 15.8381
MDST8 GDSC2 3.2469 6.9657 1.4372 10.7096
COLO205 GDSC2 3.3587 12.4973 -1.2351 23.0344
KM12 GDSC2 3.3761 6.7013 1.6772 9.0485
LS1034 GDSC2 3.5565 8.0584 1.1462 11.5079
RKO GDSC2 3.6236 12.8353 -1.1858 22.1637
HCT 116 GDSC2 3.8637 14.3746 -1.7597 23.6131
CW-2 GDSC2 3.9141 11.8908 -0.4796 18.5807
NCI-H716 GDSC2 4.1399 11.7769 -0.2447 17.0023
SNU-61 GDSC2 4.3737 7.8845 1.8465 5.9003
SW626 GDSC2 4.398 9.9479 0.8574 11.0818
SNU-1040 GDSC2 4.5681 13.3454 -0.6929 17.9367
SW837 GDSC2 4.6934 9.9141 1.0871 9.2789
CL-11 GDSC2 4.8357 13.3363 -0.4865 16.474
SW1463 GDSC2 4.954 13.5767 -0.517 16.3474
SW1116 GDSC2 5.0851 10.4734 1.0874 8.5183
HT115 GDSC2 5.491 13.6372 -0.1589 13.6853
SNU-C2B GDSC2 5.7145 15.0702 -0.6974 15.5312
RCM-1 [Human ESC] GDSC2 6.3138 18.6978 -2.0377 19.283
SW1417 GDSC2 6.3236 19.4234 -2.385 20.3709
COLO 678 GDSC2 7.9128 16.685 -0.0322 9.0742
SW620 GDSC2 10.5404 23.1035 -1.3978 10.6692
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 4.5457 10.3711 0.758 11.2715
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-2 GDSC2 2.042 5.6167 0.9886 16.7181
Hep 3B2.1-7 GDSC2 2.1573 6.8896 0.4941 18.902
Huh-7 GDSC2 3.4909 5.509 2.3658 4.9261
SNU-449 GDSC2 3.7279 8.6838 0.9713 12.0222
Hep-G2/C3A GDSC2 4.0072 5.8746 2.5616 2.7797
JHH-4 GDSC2 4.0844 8.2872 1.4425 8.6724
HLE GDSC2 4.3109 7.8007 1.8436 6.038
SNU-423 GDSC2 4.3478 13.7467 -1.0621 19.9237
SK-HEP-1 GDSC2 4.3798 6.6017 2.4573 2.6974
SNU-398 GDSC2 4.3817 7.7525 1.9155 5.5172
HuH-1 GDSC2 4.4371 14.6771 -1.4552 21.1867
JHH-6 GDSC2 5.0743 14.4375 -0.8516 17.4691
SNU-387 GDSC2 5.2887 18.9601 -2.9246 23.9942
JHH-7 GDSC2 5.7985 13.613 0.0653 12.0924
JHH-1 GDSC2 6.2601 15.1592 -0.3634 13.1125
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 184 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1648 GDSC2 -2.3461 3.5318 -2.9223 51.3055
RERF-LC-Sq1 GDSC2 -1.6488 3.5146 -2.1566 45.0399
EPLC-272H GDSC2 -1.4823 4.839 -2.4017 44.4151
NCI-H2171 GDSC2 -1.4142 3.8784 -2.0088 48.083
NCI-H292 GDSC2 -1.3892 8.2569 -3.6769 48.6016
NCI-H69 GDSC2 -1.2799 8.8272 -3.8157 45.7193
NCI-H2122 GDSC2 -0.5262 3.9527 -1.0654 36.1758
NCI-H460 GDSC2 -0.474 5.4431 -1.5451 41.3931
RERF-LC-MS GDSC2 -0.2156 6.163 -1.5642 40.0244
NCI-H322M GDSC2 -0.1969 7.3392 -2.0508 37.4831
NCI-H1734 GDSC2 -0.0897 5.5684 -1.1876 38.3752
NCI-H720 GDSC2 -0.0665 4.8637 -0.8874 33.4085
COR-L32 GDSC2 -0.0294 5.5809 -1.129 34.9621
SBC-1 GDSC2 -0.019 6.9132 -1.6813 39.2945
Lu-134-A GDSC2 0.0698 3.1356 -0.1781 33.8208
NCI-H2110 GDSC2 0.333 6.1942 -1.0064 35.6596
NCI-H1623 GDSC2 0.5602 8.3212 -1.7349 33.5763
NCI-H1975 GDSC2 0.6426 6.7328 -0.9254 30.5777
EMC-BAC-1 GDSC2 0.8329 9.3278 -1.9435 36.117
NCI-H847 GDSC2 0.8533 6.8673 -0.7731 29.9202
Lu-65 GDSC2 0.876 6.9905 -0.8064 29.2251
IST-SL2 GDSC2 0.9049 7.6586 -1.0858 30.1572
NCI-H1703 GDSC2 0.9699 11.1866 -2.7089 35.2812
NCI-H1666 GDSC2 1.0774 12.1574 -3.0821 35.1306
A-549 GDSC2 1.156 6.68 -0.3839 26.456
HCC78 GDSC2 1.1904 11.3636 -2.5891 33.6351
HCC44 GDSC2 1.1942 7.0181 -0.5018 26.8162
NCI-H2196 GDSC2 1.3165 7.3887 -0.5545 29.5576
NCI-H2009 GDSC2 1.3367 8.8248 -1.2193 29.7433
NCI-H3122 GDSC2 1.3449 10.2437 -1.8987 31.2555
HARA [Human squamous cell lung carcinoma] GDSC2 1.3709 13.0882 -3.2692 34.6126
LC-2/ad GDSC2 1.4571 6.9056 -0.1898 27.3931
COR-L311 GDSC2 1.4911 6.7397 -0.0787 23.8968
CAL-12T GDSC2 1.4972 6.4028 0.0839 25.9294
NCI-H835 GDSC2 1.5222 8.6562 -0.9615 28.1447
NCI-H2291 GDSC2 1.5422 11.3056 -2.2353 34.1661
Calu-3 GDSC2 1.7219 7.3533 -0.1444 23.4039
NCI-H2170 GDSC2 1.7617 8.9532 -0.8803 26.3795
NCI-H1944 GDSC2 1.8402 7.9763 -0.3317 23.8464
NCI-H446 GDSC2 1.919 6.2857 0.5542 19.3725
COR-L105 GDSC2 1.9341 10.7555 -1.6065 28.4317
LC-1/sq GDSC2 1.9586 10.4903 -1.4535 27.8405
COR-L303 GDSC2 1.9863 10.9802 -1.6702 31.0093
COR-L279 GDSC2 1.9979 8.2535 -0.3187 23.8669
NCI-H358 GDSC2 2.006 10.7536 -1.5404 27.9874
NCI-H1770 GDSC2 2.0342 4.7235 1.3858 16.5914
NCI-H2023 GDSC2 2.0444 11.0781 -1.6663 28.2858
NCI-H250 GDSC2 2.0636 13.0572 -2.6304 31.0466
NCI-H2066 GDSC2 2.2181 11.2982 -1.6197 28.1759
NCI-H2228 GDSC2 2.252 9.5644 -0.7304 24.2187
COR-L23 GDSC2 2.2941 9.3929 -0.6075 23.5828
NCI-H838 GDSC2 2.3074 9.3228 -0.5609 25.8164
NCI-H2030 GDSC2 2.3608 7.9133 0.1831 22.1474
NCI-H1048 GDSC2 2.4206 11.4833 -1.5323 26.7071
NCI-H1781 GDSC2 2.4508 6.3643 1.0253 15.2186
NCI-H1993 GDSC2 2.4559 6.4777 0.9747 15.4722
DMS 273 GDSC2 2.5458 6.4173 1.0878 14.5946
NCI-H3255 GDSC2 2.5476 9.3317 -0.3503 21.7118
HCC827 GDSC2 2.5477 6.6538 0.9737 15.1995
LB647-SCLC GDSC2 2.5592 8.8927 -0.1221 22.9654
NCI-H596 GDSC2 2.599 14.5682 -2.9144 30.2771
HCC366 GDSC2 2.6476 10.38 -0.7837 23.2499
EBC-1 GDSC2 2.6499 4.975 1.8852 9.9406
NCI-H727 GDSC2 2.7914 7.2465 0.9017 14.8665
NCI-H647 GDSC2 2.9133 10.0385 -0.3826 23.0059
EMC-BAC-2 GDSC2 2.9422 11.3362 -1.0059 23.2911
NCI-H64 GDSC2 2.9453 12.4068 -1.5381 25.753
NCI-H1437 GDSC2 2.9513 15.9483 -3.3027 32.3345
LXF 289 GDSC2 3.007 8.8055 0.3135 17.2802
NCI-H1792 GDSC2 3.021 9.7234 -0.1329 19.3715
NCI-H2085 GDSC2 3.0782 7.8012 0.876 14.1997
LCLC-97TM1 GDSC2 3.0851 12.8761 -1.6539 25.2528
SBC-5 GDSC2 3.0989 7.9743 0.8074 14.5056
NCI-H1793 GDSC2 3.1611 8.1183 0.7885 14.4364
NCI-H1355 GDSC2 3.2324 12.9073 -1.5456 24.4867
NCI-H2373 GDSC2 3.2343 12.1274 -1.1541 23.0605
NCI-H2461 GDSC2 3.3271 13.2083 -1.6169 24.4841
SK-MES-1 GDSC2 3.3448 8.8798 0.5621 15.1197
SBC-3 GDSC2 3.3631 11.3485 -0.6571 20.7416
NCI-H1435 GDSC2 3.379 7.751 1.1548 11.9094
PC-14 GDSC2 3.3837 9.9668 0.0508 17.533
NCI-H1341 GDSC2 3.3968 9.7801 0.155 17.4396
NCI-H520 GDSC2 3.4548 12.4052 -1.1095 22.3091
KNS-62 GDSC2 3.4558 6.2505 1.9677 7.232
NCI-H1755 GDSC2 3.4671 11.2509 -0.5223 19.8978
NCI-H524 GDSC2 3.4839 9.8936 0.1701 16.7018
Ms-1 GDSC2 3.5349 10.9053 -0.2937 18.7224
NCI-H2795 GDSC2 3.5941 15.5274 -2.5555 26.7505
Lu-99A GDSC2 3.597 9.7658 0.3262 15.6514
NCI-H2081 GDSC2 3.6723 9.809 0.3655 17.0355
NCI-H513 GDSC2 3.6895 7.0491 1.7551 7.8528
NCI-H1155 GDSC2 3.7753 7.1853 1.7539 7.6612
NCI-H2444 GDSC2 3.7786 6.5765 2.0578 6.7671
NCI-H209 GDSC2 3.7897 5.8664 2.4154 3.9857
NCI-H1436 GDSC2 3.8138 8.5636 1.0989 12.5375
BEN GDSC2 3.8487 9.7495 0.5359 15.6302
NCI-H1693 GDSC2 3.8765 6.7121 2.0639 5.7291
NCI-H1581 GDSC2 3.9742 5.816 2.5676 2.8069
NCI-H1963 GDSC2 4.0344 6.9963 2.0393 5.5331
CPC-N GDSC2 4.0467 14.7805 -1.8152 23.3567
LOU-NH91 GDSC2 4.0556 13.701 -1.2696 21.4067
DMS 53 GDSC2 4.1047 6.3246 2.4121 3.3924
NCI-H1688 GDSC2 4.1163 10.6803 0.282 14.9756
NCI-H841 GDSC2 4.1361 10.0206 0.6246 12.8557
NCI-H290 GDSC2 4.1465 7.7969 1.7288 7.9021
NCI-H1563 GDSC2 4.1478 11.9143 -0.3069 17.2606
NCI-H1650 GDSC2 4.1502 11.747 -0.2218 16.875
NCI-H2731 GDSC2 4.1529 12.3094 -0.4995 18.0878
UMC-11 GDSC2 4.1543 6.0558 2.5707 2.4816
COR-L321 GDSC2 4.1795 7.9874 1.6596 8.245
NCI-H1092 GDSC2 4.189 7.2201 2.0396 5.2227
NCI-H146 GDSC2 4.2341 8.6975 1.3513 9.9661
EKVX GDSC2 4.2482 11.5254 -0.0357 15.7964
NCI-H1869 GDSC2 4.299 11.0114 0.258 14.2932
DMS 79 GDSC2 4.329 8.4533 1.5394 7.6336
NCI-H2722 GDSC2 4.4007 6.8806 2.3411 3.2532
NCI-H1694 GDSC2 4.4275 6.6909 2.4453 2.6841
SW1271 GDSC2 4.444 8.4303 1.6316 6.9104
NCI-H2405 GDSC2 4.4476 6.832 2.3927 2.9168
NCI-H82 GDSC2 4.4847 9.4891 1.1455 9.4011
NCI-H2347 GDSC2 4.4928 8.1018 1.8233 5.9667
NCI-H1915 GDSC2 4.5117 6.2811 2.6767 1.4666
NCI-H526 GDSC2 4.5279 9.6717 1.0874 9.6152
IST-SL1 GDSC2 4.5455 7.7919 2.0059 5.3666
Calu-6 GDSC2 4.5677 6.8826 2.4414 2.4956
NCI-H1876 GDSC2 4.5792 13.3449 -0.6842 17.8757
NCI-H2029 GDSC2 4.5963 10.5505 0.7069 11.4222
NCI-H1573 GDSC2 4.6083 6.2961 2.7207 1.2032
NCI-H2369 GDSC2 4.6134 6.3697 2.6922 1.2838
NCI-H345 GDSC2 4.659 12.8403 -0.374 16.3787
NCI-H2135 GDSC2 4.6594 6.468 2.6741 1.3108
HOP-62 GDSC2 4.6781 7.3998 2.2717 3.1674
NCI-H1651 GDSC2 4.7048 8.4145 1.8153 5.4553
SHP-77 GDSC2 4.7065 7.6457 2.176 3.6014
LCLC-103H GDSC2 4.7284 15.8293 -1.8018 21.739
NCI-H1836 GDSC2 4.7375 9.8987 1.1255 10.1059
NCI-H23 GDSC2 4.7469 6.6089 2.6591 1.2814
HCC15 GDSC2 4.7525 8.9632 1.586 6.5654
NCI-H1105 GDSC2 4.7528 8.3446 1.8795 5.6988
Lu-165 GDSC2 4.7738 10.1365 1.0356 9.383
COR-L95 GDSC2 4.7925 13.0194 -0.3625 17.654
NCI-H650 GDSC2 4.8592 9.2423 1.524 6.6928
NCI-H2591 GDSC2 4.9005 7.5618 2.3282 2.5783
IA-LM GDSC2 4.9046 7.4826 2.3655 2.3982
DMS 114 GDSC2 4.9213 11.5665 0.4446 12.0383
NCI-H211 GDSC2 4.9719 10.1346 1.1732 8.2933
Lu-139 GDSC2 4.9839 7.3383 2.4713 1.8254
Lu-135 GDSC2 5.0133 14.8255 -1.0883 18.5309
NCI-H2342 GDSC2 5.0226 12.6878 -0.0304 14.4018
NCI-H661 GDSC2 5.0837 8.9515 1.8048 4.8725
NCI-H2818 GDSC2 5.1577 12.1267 0.3398 12.0612
NCI-H1838 GDSC2 5.175 12.7089 0.0688 13.618
NCI-H740 GDSC2 5.2733 8.049 2.3183 2.4506
NCI-H2869 GDSC2 5.2833 12.3069 0.3405 11.8087
RERF-LC-KJ GDSC2 5.321 12.4506 0.2971 11.939
HCC33 GDSC2 5.3312 12.7352 0.1665 13.884
ChaGo-K-1 GDSC2 5.4088 11.8525 0.6455 11.2737
COR-L88 GDSC2 5.4191 7.4009 2.6537 0.7674
NCI-H2087 GDSC2 5.424 13.0835 0.0626 12.8225
HOP-92 GDSC2 5.4371 13.9945 -0.3708 14.7167
PaCa-3 GDSC2 5.4373 13.7678 -0.2602 14.5685
A-427 GDSC2 5.465 11.4724 0.8645 8.9339
NCI-H748 GDSC2 5.5388 7.9418 2.4941 1.3579
NCI-H2803 GDSC2 5.5563 12.9572 0.2153 11.8654
NCI-H2172 GDSC2 5.6526 7.3152 2.7802 0.3412
NCI-H2227 GDSC2 5.6667 15.4788 -0.9305 16.5591
COLO 668 GDSC2 5.686 16.5769 -1.4535 18.4935
NCI-H810 GDSC2 5.7697 7.1433 2.8824 0.1093
NCI-H510A GDSC2 5.8915 7.4073 2.8355 0.165
NCI-H2141 GDSC2 5.9211 14.3062 -0.1841 12.9686
NCI-H1568 GDSC2 5.9494 18.7525 -2.3282 20.9106
NCI-H2810 GDSC2 6.0475 17.2325 -1.5135 17.9973
NCI-H2595 GDSC2 6.2397 12.9624 0.662 8.5759
VMRC-LCD GDSC2 6.2431 13.566 0.3817 9.863
SK-LU-1 GDSC2 6.2699 14.4384 -0.0132 11.5868
NCI-H196 GDSC2 6.4907 15.2554 -0.2556 12.2466
SW1573 GDSC2 6.4945 17.596 -1.3753 16.6565
ABC-1 GDSC2 6.8251 19.7592 -2.1919 18.8417
NCI-H2804 GDSC2 6.8969 19.4835 -2.0083 18.1182
NCI-H1299 GDSC2 6.9559 21.1744 -2.787 20.4252
NCI-H441 GDSC2 8.1892 24.5792 -3.5747 20.5293
NCI-H226 GDSC2 8.4543 22.1145 -2.2185 16.2154
LK-2 GDSC2 8.4883 19.2924 -0.8787 11.5564
NCI-H522 GDSC2 8.5772 20.3306 -1.3038 12.9679
⏷ Show the Full List of 184 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 3.9664 8.8108 1.0944 10.8056
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-11 GDSC2 -1.8016 3.3849 -2.2869 51.1093
TE-6 GDSC2 -0.8516 7.984 -3.0052 42.17
EC-GI-10 GDSC2 -0.0556 3.8669 -0.5261 31.9585
T.T GDSC2 -0.0327 5.6618 -1.1654 35.0974
OE21 GDSC2 0.3445 4.2634 -0.2257 28.9572
TE-15 GDSC2 0.4949 7.1259 -1.2517 32.3149
KYSE-450 GDSC2 0.7432 7.1148 -0.9964 30.4473
TE-4 GDSC2 0.9046 3.6931 0.5738 22.9672
OE19 GDSC2 0.9076 9.1063 -1.7658 32.3785
KYSE-180 GDSC2 1.0471 5.8177 -0.1068 25.637
TE-10 GDSC2 1.1495 6.4588 -0.2894 29.1344
KYSE-150 GDSC2 1.2375 7.7445 -0.7994 28.5509
TE-5 GDSC2 1.5557 9.2574 -1.2213 28.337
KYSE-410 GDSC2 1.6916 8.4718 -0.712 25.9446
KYSE-510 GDSC2 2.0702 8.1213 -0.1869 25.0005
KYSE-270 GDSC2 2.0724 8.5236 -0.3817 23.3119
KYSE-520 GDSC2 2.2611 11.2912 -1.578 27.3351
KYSE-140 GDSC2 3.1099 7.4611 1.0731 13.0604
TE-9 GDSC2 3.1112 7.0194 1.2948 11.8531
TE-8 GDSC2 3.2779 12.1068 -1.1072 22.766
TE-1 GDSC2 3.3211 9.5422 0.2111 16.9297
OE33 GDSC2 3.6088 11.5039 -0.5326 19.5753
COLO 680N GDSC2 4.3905 12.3585 -0.3397 16.8368
KYSE-70 GDSC2 4.9539 15.1193 -1.2781 19.379
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IGROV-1 GDSC2 -4.7364 3.0032 -5.3874 63.9141
A2780 GDSC2 -3.2356 9.3672 -6.0645 53.6848
JHOS-4 GDSC2 -1.5058 5.4178 -2.6377 48.9771
OC 314 GDSC2 0.8458 5.9015 -0.3504 28.2195
OVISE GDSC2 0.943 11.0347 -2.6605 34.6275
SK-OV-3 GDSC2 2.3683 15.6334 -3.6455 32.5871
OVK18 GDSC2 2.401 8.1387 0.1087 20.0416
OVCAR-5 GDSC2 2.4858 13.5779 -2.5185 29.5449
DOV13 GDSC2 2.5862 6.2645 1.2001 13.8675
OVTOKO GDSC2 2.6755 12.3839 -1.7584 26.7298
OAW42 GDSC2 2.9724 13.8874 -2.2548 27.465
FU-OV-1 GDSC2 2.9745 10.497 -0.5591 21.8925
TOV-21G GDSC2 3.0744 5.8631 1.8396 8.9422
JHOS-2 GDSC2 3.193 13.4602 -1.855 27.7628
RMG-I GDSC2 3.456 11.2879 -0.5499 20.5138
EFO-27 GDSC2 3.5651 6.416 1.9725 6.94
OV56 GDSC2 3.7646 5.6722 2.4922 3.618
OVCAR-3 GDSC2 3.8643 8.8041 1.0187 11.4455
ES-2 GDSC2 4.0777 6.1715 2.467 3.1513
OVCAR-4 GDSC2 4.1738 6.5817 2.3356 3.6716
TOV-112D GDSC2 4.2413 7.9225 1.7355 6.7579
Caov-3 GDSC2 4.3442 9.5216 1.0273 11.5909
TYK-nu GDSC2 4.463 11.0956 0.3402 13.5257
OVKATE GDSC2 4.6543 12.6536 -0.2854 16.3772
Kuramochi GDSC2 4.7924 12.1952 0.0431 14.2127
OV-90 GDSC2 5.3017 10.9557 1.0021 8.5482
Caov-4 GDSC2 5.3854 12.3082 0.4105 11.5653
OAW28 GDSC2 5.4997 11.3296 0.9551 8.4269
EFO-21 GDSC2 5.5584 15.3061 -0.924 16.751
OVCAR-8 GDSC2 7.4332 18.0696 -0.9717 13.5259
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DAN-G GDSC2 0.1789 5.1642 -0.7418 31.7886
PaTu 8902 GDSC2 1.3994 8.4237 -0.9666 27.9365
HPAC GDSC2 2.0763 9.0383 -0.6308 24.3589
Panc 02.03 GDSC2 2.3442 10.596 -1.1589 25.6037
Panc 10.05 GDSC2 2.4202 10.5271 -1.0572 24.9939
PL4 GDSC2 2.926 10.9124 -0.8081 22.5533
PaTu 8988t GDSC2 2.946 9.1637 0.0822 18.5737
Panc 08.13 GDSC2 3.9015 12.4429 -0.765 19.8112
QGP-1 GDSC2 3.994 14.9173 -1.9257 23.8492
BxPC-3 GDSC2 4.0047 12.5915 -0.7569 19.5252
KP-1N GDSC2 4.0685 10.5248 0.3222 14.5173
SW1990 GDSC2 4.1189 8.1909 1.5155 8.4393
Panc 03.27 GDSC2 4.2754 13.0571 -0.7756 19.3735
SUIT-2 GDSC2 4.5 6.8322 2.4243 2.6787
Hs 766T GDSC2 4.5013 10.319 0.751 11.7092
KP-2 GDSC2 4.8705 13.2127 -0.3997 16.0254
KP-4 GDSC2 4.9005 9.5992 1.3814 7.3555
SU.86.86 GDSC2 4.9325 13.0647 -0.281 15.3741
MZ-PC-1 GDSC2 5.2143 12.5264 0.1855 14.0116
CFPAC-1 GDSC2 5.2892 15.7489 -1.338 18.8854
Capan-2 GDSC2 5.3053 18.0493 -2.4612 22.6139
Panc 04.03 GDSC2 5.3873 16.6947 -1.7309 20.4619
HuP-T3 GDSC2 5.3874 14.5682 -0.6866 16.1443
HuP-T4 GDSC2 5.6035 13.637 -0.0801 13.1152
KP-3 GDSC2 5.8848 10.7547 1.4619 5.3337
HPAF-II GDSC2 6.1895 18.0107 -1.7915 18.6953
PSN1 GDSC2 6.2889 13.7002 0.348 9.9389
YAPC GDSC2 6.3019 19.7419 -2.5564 20.9352
MIA PaCa-2 GDSC2 6.6796 15.1135 -0.0656 11.1112
Capan-1 GDSC2 6.7348 18.2985 -1.5482 16.8394
AsPC-1 GDSC2 9.2601 22.9983 -2.1176 14.7
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC2 3.5017 9.6931 0.2848 16.0984
MSTO-211H GDSC2 3.9512 10.7603 0.1133 15.804
MPP 89 GDSC2 4.5757 12.2943 -0.167 15.6475
NCI-H2052 GDSC2 5.0702 14.742 -1.0046 18.0836
NCI-H2452 GDSC2 5.0714 11.6682 0.5016 11.754
IST-Mes1 GDSC2 6.2841 17.3726 -1.4141 17.1885
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC2 -0.0305 4.0417 -0.5558 31.9678
VCaP GDSC2 2.5196 12.1005 -1.7527 27.1553
22Rv1 GDSC2 3.1602 15.6737 -2.9892 29.0058
PC-3 GDSC2 3.8244 9.2241 0.7784 12.8005
DU145 GDSC2 4.0455 5.6487 2.692 2.0395
NCI-H660 GDSC2 4.5566 8.984 1.4422 8.6773
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 3.1796 5.4195 2.1523 6.9128
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-388 GDSC2 -2.2181 3.5172 -2.7785 54.1427
A-431 GDSC2 -0.7237 4.3716 -1.4187 42.6004
CP50-MEL-B GDSC2 1.028 6.0161 -0.2139 29.3292
VMRC-MELG GDSC2 1.3845 9.0609 -1.2876 31.9961
RPMI-7951 GDSC2 1.4843 6.241 0.1457 22.8712
MZ-MEL-2 GDSC2 1.5097 6.5448 0.0305 26.1388
MZ-MEL-7 GDSC2 2.0646 7.7299 -0.0011 24.1365
COLO 800 GDSC2 2.1564 7.9443 -0.0203 23.8927
COLO 792 GDSC2 2.1565 9.9359 -1.0003 25.5797
A101D GDSC2 2.1976 6.6453 0.6503 17.9766
WM115 GDSC2 2.2436 5.9642 1.0215 15.8878
UACC-62 GDSC2 2.2626 5.9442 1.0494 15.6793
IGR-37 GDSC2 2.5015 6.5333 0.99 15.2519
Mel Ho GDSC2 2.5364 7.7188 0.4388 20.1962
DJM-1 GDSC2 2.5832 8.9103 -0.1095 22.8238
COLO 783 GDSC2 2.6518 16.215 -3.6912 33.9794
HT-144 GDSC2 2.721 5.4921 1.7028 10.7188
A2058 GDSC2 2.765 4.8144 2.0727 8.5575
Hs 938.T GDSC2 2.7663 8.7046 0.1546 20.9081
SK-MEL-3 GDSC2 2.9027 14.7897 -2.7649 31.1922
WM793 GDSC2 2.9239 9.0675 0.1111 18.4977
LOX-IMVI GDSC2 2.9873 14.9453 -2.7709 28.8781
SK-MEL-28 GDSC2 3.049 14.5164 -2.5043 30.0915
CHL-1 GDSC2 3.1259 7.7088 0.9631 13.6071
SK-MEL-31 GDSC2 3.1698 8.5898 0.5602 17.4743
IST-MEL1 GDSC2 3.2407 7.2168 1.3063 11.774
G-mel GDSC2 3.3053 7.6669 1.1355 12.2046
GAK GDSC2 3.3504 5.748 2.1326 6.5753
WM1552C GDSC2 3.3874 8.8028 0.6358 14.6307
A-375 GDSC2 3.6855 7.8273 1.3646 10.0087
SK-MEL-24 GDSC2 3.7687 9.0638 0.8143 12.7486
Hs 940.T GDSC2 3.811 9.0378 0.8606 13.9259
Mel JuSo GDSC2 3.8767 8.4658 1.1964 10.4679
COLO 679 GDSC2 3.9377 6.1171 2.3983 3.7801
G-361 GDSC2 4.0206 8.1076 1.4835 8.5906
WM35 GDSC2 4.0237 10.0272 0.5347 13.9311
SK-MEL-1 GDSC2 4.0363 5.9798 2.5308 2.9744
M14 GDSC2 4.0969 8.506 1.344 9.1762
IPC-298 GDSC2 4.1848 12.863 -0.7499 20.9027
SK-MEL-5 GDSC2 4.2172 9.3816 1.002 10.7271
SH-4 GDSC2 4.2542 6.47 2.4404 2.9854
WT2-iPS GDSC2 4.3337 7.9913 1.7673 6.4021
HMV-II GDSC2 4.4367 16.0112 -2.1193 23.4386
MMAc-SF GDSC2 4.4885 12.1091 -0.1413 17.3834
SK-MEL-30 GDSC2 4.554 17.8777 -2.9564 27.3954
RVH-421 GDSC2 4.6111 8.2316 1.8404 6.2097
IGR-1 GDSC2 4.718 6.2301 2.8011 0.7534
SK-MEL-2 GDSC2 4.931 5.9862 2.9807 0.1466
MeWo GDSC2 4.9379 11.905 0.2912 13.0628
CP66-MEL GDSC2 4.9857 16.4232 -1.899 21.5025
LB2518-MEL GDSC2 5.0684 12.946 -0.1236 15.8852
UACC-257 GDSC2 5.5004 11.7275 0.7666 9.3487
451Lu GDSC2 5.6812 7.6467 2.6705 0.6202
COLO 829 GDSC2 5.7493 11.8824 0.8561 8.4753
WM278 GDSC2 6.3236 14.967 -0.2291 12.4282
LB373-MEL-D GDSC2 6.3914 18.6385 -1.9535 20.3123
EquiPSC Line K2 GDSC2 2.8748 11.1166 -0.954 25.5369
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 0.2048 8.7182 -2.2711 36.3746
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh41 GDSC2 -3.4179 0.8915 -3.5402 58.6326
Rh30 GDSC2 -0.0907 4.5628 -0.8021 33.1999
G-401 GDSC2 0.2472 7.7538 -1.7858 34.9492
RD GDSC2 1.2414 9.9828 -1.8691 31.5172
MES-SA GDSC2 1.6382 9.5766 -1.2996 28.3394
TE 441.T GDSC2 2.2365 14.6604 -3.2755 34.3172
STS-0421 GDSC2 2.2453 13.1774 -2.5294 32.5671
SW982 GDSC2 2.6712 9.8778 -0.5129 22.0542
Hs 633.T GDSC2 2.6925 5.3355 1.7522 10.8438
VA-ES-BJ GDSC2 2.7948 6.6662 1.1925 13.2949
EW-8 GDSC2 2.8219 5.8526 1.619 10.8805
SK-LMS-1 GDSC2 3.2185 8.2673 0.7625 14.4185
A-204 GDSC2 3.3309 14.8438 -2.4315 27.0512
KYM-1 GDSC2 3.3584 8.9656 0.5305 15.2448
SK-UT-1 GDSC2 3.4317 8.1772 0.9851 12.6861
SW872 GDSC2 3.4529 8.0581 1.0621 12.2203
MFH-ino GDSC2 3.9603 8.7112 1.139 10.8799
GCT GDSC2 4.2239 12.1551 -0.3673 17.3462
HT-1080 GDSC2 4.5328 6.0845 2.7715 1.0358
SW684 GDSC2 4.7774 17.1939 -2.4415 23.6762
RKN GDSC2 4.9971 10.4122 1.0571 8.8383
G-402 GDSC2 6.2634 27.2482 -6.2869 29.4194
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AGS GDSC2 -2.3683 2.3922 -2.6611 50.3574
HGC-27 GDSC2 -2.0761 3.2729 -2.5557 48.2154
NCI-N87 GDSC2 -1.7327 6.9585 -3.4848 46.807
HSC-39 GDSC2 -0.8356 6.246 -2.2492 41.7069
IM95 GDSC2 0.1935 7.7089 -1.8194 35.2588
23132/87 GDSC2 0.4129 6.6803 -1.1361 32.2502
MKN1 GDSC2 0.5831 12.0905 -3.5117 37.5784
SK-GT-2 GDSC2 0.7103 5.0306 -0.1258 27.023
GCIY GDSC2 0.7788 5.6339 -0.3044 27.5416
RERF-GC-1B GDSC2 0.9497 7.8268 -1.12 30.113
TMK-1 GDSC2 1.4832 9.0372 -1.1828 31.2573
NUGC-3 GDSC2 2.0129 8.2721 -0.3138 23.2044
Fu97 GDSC2 2.548 11.6068 -1.4819 26.7092
SNU-5 GDSC2 3.1717 8.143 0.7851 14.4257
SNU-1 GDSC2 3.2494 5.0298 2.4068 5.3046
MKN45 GDSC2 3.4292 11.4319 -0.644 20.5124
Hs 746.T GDSC2 3.4737 6.4665 1.8743 7.7085
SNU-16 GDSC2 3.4947 6.274 1.9873 7.2335
MKN7 GDSC2 3.6224 7.3216 1.5667 9.3144
SCH GDSC2 4.3019 11.7393 -0.1006 17.6691
ECC12 GDSC2 4.353 10.6455 0.4799 13.0872
KATO III GDSC2 5.1825 9.8573 1.4442 6.532
MKN28 GDSC2 5.2395 14.1173 -0.573 15.979
OCUM-1 GDSC2 5.2461 15.9462 -1.4672 19.4473
RF-48 GDSC2 5.7182 14.7204 -0.5249 14.8118
ECC10 GDSC2 5.8242 18.79 -2.4387 21.4974
TGBC11TKB GDSC2 5.914 20.3851 -3.1576 23.3919
NUGC-4 GDSC2 6.1439 16.1006 -0.8958 15.4971
SNG-M GDSC2 2.9114 7.2309 1.0156 13.9175
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
K5 GDSC2 -0.2376 7.1651 -2.0161 37.5734
8305C GDSC2 2.5146 14.656 -3.0312 30.795
CAL-62 GDSC2 2.8171 6.1991 1.4437 11.8588
ASH-3 GDSC2 2.8437 6.6153 1.2615 12.779
KMH-2 GDSC2 3.1663 8.2072 0.7484 16.4345
IHH-4 GDSC2 3.4485 4.6027 2.7837 2.6987
FTC-133 GDSC2 3.5111 5.3424 2.4647 4.3279
B-CPAP GDSC2 3.7803 5.6649 2.507 3.5052
HTC-C3 GDSC2 3.9926 8.9047 1.0679 10.8863
CGTH-W-1 GDSC2 4.1137 7.172 2.0102 5.6922
TT2609-C02 GDSC2 4.2823 8.7738 1.349 8.7492
8505C GDSC2 4.5728 7.2095 2.2953 3.2109
BHT-101 GDSC2 4.7416 10.5569 0.8085 10.6057
ML-1 [Human leukemia] GDSC2 4.767 8.4808 1.8244 5.9912
TT GDSC2 5.1121 11.6196 0.5537 11.4126
WRO GDSC2 7.6493 20.5689 -2.0164 16.8528
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DOK GDSC2 -3.9819 1.6612 -4.2646 61.6211
HSC-2 GDSC2 -3.008 1.3264 -3.1613 55.4125
CAL-33 GDSC2 -2.8823 2.1134 -3.1614 54.1955
BB49-HNC GDSC2 -2.7452 3.3286 -3.3012 52.8889
JHU-029 GDSC2 -2.1266 2.7272 -2.473 53.7845
JHU-011 GDSC2 -1.9275 4.915 -2.9094 51.7783
Detroit 562 GDSC2 -1.5551 3.8372 -2.1496 44.4621
HO-1-u-1 GDSC2 -1.477 3.4488 -1.9505 44.7722
BB30-HNC GDSC2 -1.4327 1.7858 -1.5426 47.8614
PCI-15A GDSC2 -1.4062 2.4002 -1.6188 47.7207
SAT [Human HNSCC] GDSC2 -1.1759 7.5331 -3.1439 43.8166
JHU-022 GDSC2 -0.9785 6.2817 -2.4143 41.8107
NCI-H3118 GDSC2 -0.8035 8.183 -3.0439 42.017
BICR 22 GDSC2 -0.0741 4.1361 -0.6347 32.4785
Ca9-22 GDSC2 0.016 5.9144 -1.2182 34.1938
KON GDSC2 0.098 4.6457 -0.6296 35.538
OSC-19 GDSC2 0.3593 3.4245 0.0601 31.2197
SCC-15 GDSC2 0.361 4.1847 -0.1802 28.688
HO-1-N-1 GDSC2 0.5074 5.2201 -0.4166 29.1043
SCC-4 GDSC2 0.7927 6.1946 -0.5333 28.4555
BICR 10 GDSC2 0.8399 9.2232 -1.8869 32.9777
SCC-9 GDSC2 0.8526 9.6289 -2.0684 33.4404
PCI-06A GDSC2 1.2186 11.0833 -2.4259 35.7957
CAL-27 GDSC2 1.4295 7.8088 -0.6435 26.563
LB771-HNC GDSC2 1.4872 6.6294 -0.0312 23.6917
UPCI-SCC-090 GDSC2 1.5103 6.251 0.1671 22.6772
FaDu GDSC2 1.6254 8.0292 -0.5611 25.5484
BHY GDSC2 1.7285 5.8315 0.5777 22.43
SAS GDSC2 1.9429 7.7053 -0.1035 22.4831
KOSC-2 GDSC2 2.089 8.2728 -0.2435 25.1931
PCI-04B GDSC2 2.1472 7.8819 0.0017 21.3376
HSC-3 GDSC2 2.3068 8.4852 -0.1479 21.5317
PE/CA-PJ15 GDSC2 2.3803 8.2714 0.0245 22.873
HSC-4 GDSC2 3.0444 8.3571 0.5695 15.8887
BICR 78 GDSC2 3.0568 9.9805 -0.2309 19.7186
SKN-3 GDSC2 3.8032 10.9363 -0.092 17.1274
OSC-20 GDSC2 4.0016 10.975 0.046 15.9999
SCC-25 GDSC2 4.0675 12.3408 -0.5823 20.499
BICR 31 GDSC2 4.1715 9.6285 0.8457 13.057
PCI-30 GDSC2 5.5605 13.8419 -0.2094 14.0925
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-29 GDSC2 -2.7434 3.7207 -3.4104 52.7782
BFTC-905 GDSC2 1.451 7.5872 -0.5174 25.9664
HT-1197 GDSC2 2.3257 8.5971 -0.1858 21.6462
UM-UC-3 GDSC2 2.9815 6.205 1.5878 10.9062
5637 GDSC2 3.3754 9.3135 0.3706 16.0034
647V GDSC2 3.6271 6.9659 1.7476 8.0412
SW1710 GDSC2 3.7573 6.8647 1.899 6.9015
SW780 GDSC2 3.9758 6.3077 2.3326 4.0599
639V GDSC2 4.0228 7.6961 1.6879 7.4738
KU-19-19 GDSC2 4.8635 7.3172 2.4156 2.2193
RT-112 GDSC2 5.1066 18.1961 -2.6852 23.6915
HT-1376 GDSC2 5.6358 9.5448 1.8616 3.7893
J82 GDSC2 5.7482 14.4669 -0.3809 14.1458
T24 GDSC2 5.946 10.303 1.6996 4.6626
TCCSUP GDSC2 6.0956 15.794 -0.7812 15.1341
RT-4 GDSC2 6.3668 15.3426 -0.3794 12.9881
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-39 GDSC2 -3.11 1.8297 -3.3535 55.9186
OMC-1 [Human cervical carcinoma] GDSC2 -1.6594 3.8274 -2.2604 49.9913
BPH-1 GDSC2 -1.4603 5.2181 -2.5147 44.4485
ME-180 GDSC2 -0.9574 9.8269 -3.9403 43.757
SW954 GDSC2 -0.2106 5.6304 -1.3403 39.4424
PA-1 GDSC2 -0.2076 6.0399 -1.5047 36.0722
OVCA420 GDSC2 0.2116 9.1984 -2.4881 37.571
OVMIU GDSC2 0.5787 9.07 -2.0679 34.4363
NCC-IT GDSC2 0.7028 5.6626 -0.3956 28.9941
ACC-OV7 GDSC2 1.071 7.9422 -1.0553 32.4806
UWB1.289 GDSC2 1.2569 10.3566 -2.0361 34.6948
JHOS-3 GDSC2 1.8602 10.1109 -1.3564 30.4389
Ca Ski GDSC2 1.9085 8.5646 -0.5538 24.5766
DSH1 GDSC2 2.0038 6.4818 0.5433 19.1482
NEC8 GDSC2 2.2566 8.0341 0.0282 20.8694
OVCA433 GDSC2 2.503 12.4743 -1.9535 30.1632
DoTc2 4510 GDSC2 2.5417 7.245 0.6774 16.7758
SKG-IIIa GDSC2 2.8893 9.7853 -0.277 20.3949
SKN GDSC2 2.9256 6.71 1.2872 12.4062
NT2-D1 GDSC2 2.9861 9.4812 -0.0419 19.5317
PWR-1E GDSC2 3.0511 6.4799 1.5119 10.8233
C-33 A GDSC2 3.2909 6.954 1.48 10.3587
KGN GDSC2 3.3653 11.5916 -0.7768 21.7114
C-4-I GDSC2 3.4622 9.2166 0.4907 15.1766
TC-YIK GDSC2 3.5303 9.6802 0.3147 15.878
JAR GDSC2 3.6364 7.1306 1.6729 9.537
SiHa GDSC2 3.7216 5.4796 2.5553 3.362
JEG-3 GDSC2 3.7339 9.0292 0.8039 14.4604
HEY GDSC2 3.7727 5.9072 2.383 4.1983
SiSo GDSC2 4.0427 6.4315 2.3191 4.0031
OV17R GDSC2 4.1243 20.7241 -4.7199 32.295
SW962 GDSC2 4.1409 7.616 1.8133 7.4005
MS751 GDSC2 4.3461 8.2423 1.6542 6.9838
HT-3 GDSC2 4.4252 10.9391 0.3892 13.3716
LB831-BLC GDSC2 4.5817 17.3896 -2.6916 24.8402
SW756 GDSC2 4.9351 8.9428 1.7153 5.5723
PEO1 GDSC2 5.2365 16.5361 -1.7653 20.5154
HEC-1 GDSC2 5.3275 12.898 0.0849 12.912
HeLa GDSC2 7.5531 17.6641 -0.7043 12.3055
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7794).
3 Company report (BioOncology)