Details of the Drug

General Information of Drug (ID: DMT819N)

Drug Name
Pegorgotein
Synonyms Dismutec; Conjugated bSOD, Oxis; SOD, Sanofi; Superoxide dismutase, Sanofi; PEG-SOD, Oxis; PEG-SOD, Sanofi; PEG-bSOD, Oxis; PEG-bSOD, Sanofi; PEG-superoxide dismutase, Enzon Inc
Indication
Disease Entry ICD 11 Status REF
Head injury NA00-NA0Z Terminated [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 175.18
Logarithm of the Partition Coefficient (xlogp) -1.3
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C7H13NO4
IUPAC Name
2-methoxyethyl 4-amino-4-oxobutanoate
Canonical SMILES
COCCOC(=O)CCC(=O)N
InChI
InChI=1S/C7H13NO4/c1-11-4-5-12-7(10)3-2-6(8)9/h2-5H2,1H3,(H2,8,9)
InChIKey
VJDVWBDSMDTODO-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
3086673
CAS Number
155773-57-2
TTD ID
D0N4SU

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Superoxide dismutase Cu-Zn (SOD Cu-Zn) TT6RVLG SODC_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005631)
2 Clinical trials with Dismutec (pegorgotein; polyethylene glycol-conjugated superoxide dismutase; PEG-SOD) in the treatment of severe closed head injury. Adv Exp Med Biol. 1994;366:389-400.