Details of the Drug

General Information of Drug (ID: DMT819N)

Drug Name

Pegorgotein

Synonyms

Dismutec; Conjugated bSOD, Oxis; SOD, Sanofi; Superoxide dismutase, Sanofi; PEG-SOD, Oxis; PEG-SOD, Sanofi; PEG-bSOD, Oxis; PEG-bSOD, Sanofi; PEG-superoxide dismutase, Enzon Inc

Indication

Disease Entry	ICD 11	Status	REF
Head injury	NA00-NA0Z	Terminated	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

175.18

Logarithm of the Partition Coefficient (xlogp)

-1.3

Rotatable Bond Count (rotbonds)

7

Hydrogen Bond Donor Count (hbonddonor)

1

Hydrogen Bond Acceptor Count (hbondacc)

4

Chemical Identifiers

Formula: C7H13NO4
IUPAC Name: 2-methoxyethyl 4-amino-4-oxobutanoate
Canonical SMILES: COCCOC(=O)CCC(=O)N
InChI: InChI=1S/C7H13NO4/c1-11-4-5-12-7(10)3-2-6(8)9/h2-5H2,1H3,(H2,8,9)
InChIKey: VJDVWBDSMDTODO-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 3086673
CAS Number: 155773-57-2
TTD ID: D0N4SU

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Superoxide dismutase Cu-Zn (SOD Cu-Zn)	TT6RVLG	SODC_HUMAN	Modulator	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005631)
2	Clinical trials with Dismutec (pegorgotein; polyethylene glycol-conjugated superoxide dismutase; PEG-SOD) in the treatment of severe closed head injury. Adv Exp Med Biol. 1994;366:389-400.