Details of the Drug

General Information of Drug (ID: DMTAYMR)

• Drug Name: Carboxydichlorofluorescein
• Synonyms: 5,6-carboxydichlorofluorescein
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 445.204
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 1
  Hydrogen Bond Donor Count; 3
  Hydrogen Bond Acceptor Count; 7
• Chemical Identifiers:
  Formula: C21H10Cl2O7
  IUPAC Name: 7',8'-dichloro-3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-carboxylic acid
  Canonical SMILES: C1=CC=C2C(=C1)C(=O)OC23C4=C(C(=C(C=C4)O)C(=O)O)OC5=CC(=C(C(=C35)Cl)Cl)O
  InChI: InChI=1S/C21H10Cl2O7/c22-16-12(25)7-13-15(17(16)23)21(9-4-2-1-3-8(9)20(28)30-21)10-5-6-11(24)14(19(26)27)18(10)29-13/h1-7,24-25H,(H,26,27)
  InChIKey: SQVCXKJBMHVPIO-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 129670681
  VARIDT ID: DR00365

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 5 (ABCC5)	DTYVM24	MRP5_HUMAN	Substrate	[1]

References

• [1] Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32.