Details of the Drug

General Information of Drug (ID: DMTFUM4)

Drug Name

IMMU-114

Synonyms

HLA-DR mAb (cancer), Immunomedics

Indication

Disease Entry	ICD 11	Status	REF
Haematological malignancy	2B33.Y	Phase 1	[1]
leukaemia	2A60-2B33	Phase 1	[2]
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Drug Type

Antibody

Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MHC class II antigen DR (HLA-DR)	TTYA75N	DRA_HUMAN ; 2B1F_HUMAN ; DRB3_HUMAN ; DRB4_HUMAN ; DRB5_HUMAN	Not Available	[3]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039238)
3	The humanized anti-HLA-DR moAb, IMMU-114, depletes APCs and reduces alloreactive T cells: implications for preventing GVHD. Bone Marrow Transplant. 2012 Jul;47(7):967-80.