Details of the Drug

General Information of Drug (ID: DMTKU46)

• Drug Name: Bismuth
• Synonyms: Bismut; Bismuto; Wismut; Bismuth standard for AAS; Bismuth standard for ICP; LTBB002773; Bismuth(III) nitrate solution; Bismuth, elemental; Bismuth-209; BISMUTH, 99.95%; BISMUTH, 99.999%; 83Bi

Indication

Disease Entry	ICD 11	Status	REF
Diarrhea	ME05.1	Approved	[1]

• Therapeutic Class: Antidiarrheals
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 208.98
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 0
  Hydrogen Bond Donor Count; 0
  Hydrogen Bond Acceptor Count; 0
• Chemical Identifiers:
  Formula: Bi
  IUPAC Name: bismuth
  Canonical SMILES: [Bi]
  InChI: InChI=1S/Bi
  InChIKey: JCXGWMGPZLAOME-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 5359367
  ChEBI ID: CHEMBL33301
  CAS Number: 7440-69-9
  TTD ID: D0OG5K

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serum albumin (ALB)	TTFNGC9	ALBU_HUMAN	Binder	[2]

Molecular Expression Atlas of This Drug

• The Studied Disease: Diarrhea
• ICD Disease Classification: ME05.1

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Serum albumin (ALB)	DTT	ALB	7.92E-01	-0.07	-0.44

References

• [1] The effect of histamine H2-receptor blockade on bismuth absorption from three ulcer-healing compounds. Gastroenterology. 1991 Oct;101(4):889-94.
• [2] Competitive binding of bismuth to transferrin and albumin in aqueous solution and in blood plasma. J Biol Chem. 2001 Mar 23;276(12):8829-35.