| Drug Name |
|
| Synonyms |
|
| #Ro5 Violations (Lipinski): 1 |
Molecular Weight (mw) |
|
|
| Logarithm of the Partition Coefficient (xlogp) |
|
| Rotatable Bond Count (rotbonds) |
|
| Hydrogen Bond Donor Count (hbonddonor) |
|
| Hydrogen Bond Acceptor Count (hbondacc) |
|
| ADMET Property |
- Absorption Cmax
-
The maximum plasma concentration (Cmax) of drug is 200-250 mcg/L
[1]
- Absorption Tmax
-
The time to maximum plasma concentration (Tmax) is 1 h
[1]
- Bioavailability
-
The bioavailability of drug is 33%
[1]
- Clearance
-
The renal clearance of drug is 75 mL/min
[1]
- Elimination
-
A single oral dose of losartan leads to 4% recovery in the urine as unchanged losartan, 6% in the urine as the active metabolite
[2]
- Half-life
-
The concentration or amount of drug in body reduced by one-half in 1.5 - 2.5 hours
[1]
- Metabolism
-
The drug is metabolized via the cytochrome P450s like CYP2C9
[1]
- Vd
-
The volume of distribution (Vd) of drug is 34.4 +/- 17.9 L
[1]
|
| Cross-matching ID |
|
|
|
|
|
|
|
|
