Details of the Drug

General Information of Drug (ID: DMTLRGZ)

Drug Name
SGC-CBP30
Synonyms
SGC-CBP30; 1613695-14-9; (s)-4-(1-(2-(3-chloro-4-methoxyphenethyl)-5-(3,5-dimethylisoxazol-4-yl)-1h-benzo[d]imidazol-1-yl)propan-2-yl)morpholine; 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole; 2-[2-(3-Chloro-4-Methoxyphenyl)ethyl]-5-(3,5-Dimethyl-1,2-Oxazol-4-Yl)-1-[(2s)-2-(Morpholin-4-Yl)propyl]-1h-Benzimidazole; 2LO; C28H33ClN4O3; GTPL7529; SCHEMBL17512896; CHEMBL3622373; AOB4800; MolPort-035-395-859; BDBM188519; EX-A2159; ZINC96170456; s7256
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 509
Logarithm of the Partition Coefficient (xlogp) 5.2
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C28H33ClN4O3
IUPAC Name
4-[(2S)-1-[2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]propan-2-yl]morpholine
Canonical SMILES
CC1=C(C(=NO1)C)C2=CC3=C(C=C2)N(C(=N3)CCC4=CC(=C(C=C4)OC)Cl)C[C@H](C)N5CCOCC5
InChI
InChI=1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1
InChIKey
GEPYBHCJBORHCE-SFHVURJKSA-N
Cross-matching ID
PubChem CID
72201027
TTD ID
D03XXT

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CREB-binding protein (CREBBP) TTFRCTK CBP_HUMAN Inhibitor [2]
Histone acetyltransferase KAT6B (KAT6B) TTH4VJL KAT6B_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Gene/Protein Processing [3]
Interleukin-17A (IL17A) OTY72FT2 IL17_HUMAN Gene/Protein Processing [3]
Interleukin-21 (IL21) OTABCY4W IL21_HUMAN Gene/Protein Processing [3]
Interleukin-22 (IL22) OTW31FU9 IL22_HUMAN Gene/Protein Processing [3]
Interleukin-23 receptor (IL23R) OTT6L7U8 IL23R_HUMAN Gene/Protein Processing [3]
T-box transcription factor TBX21 (TBX21) OT3UK5KE TBX21_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 -3.6546 -2.3693 -3.6546 59.9688
EW-3 GDSC2 2.8152 5.3777 1.1831 5.8956
A-673 GDSC2 3.3733 5.3357 1.5749 2.4074
HOS GDSC2 3.4477 6.5192 1.0711 5.1774
EW-24 GDSC2 3.4642 5.1696 1.6996 1.6097
CAL-78 GDSC2 3.5899 5.7655 1.5068 2.4363
TC-71 GDSC2 3.6233 8.0346 0.464 8.4017
SK-PN-DW GDSC2 3.7413 7.4651 0.8152 6.0957
EW-11 GDSC2 3.802 6.6696 1.2226 3.6513
HuO-3N1 GDSC2 3.8601 12.8149 -1.7043 18.9923
EW-1 GDSC2 3.8888 9.0643 0.1503 9.6301
CADO-ES1 GDSC2 3.9267 6.0797 1.5518 1.747
MHH-ES-1 GDSC2 4.1558 8.0382 0.809 5.3543
MG-63 GDSC2 4.2028 6.0982 1.6766 0.9267
NOS-1 [Human HNSCC] GDSC2 4.2372 6.4748 1.5412 1.4502
SaOS-2 GDSC2 4.3147 8.3816 0.7478 5.4174
SK-ES-1 GDSC2 4.3154 5.9697 1.7738 0.517
ES8 GDSC2 4.3381 6.2258 1.6863 0.7877
ES7 GDSC2 4.4611 6.9808 1.4415 1.6563
EW-22 GDSC2 4.5061 7.2201 1.3646 1.952
U2OS GDSC2 4.553 13.7874 -1.6746 17.2528
EW-16 GDSC2 4.611 14.6551 -2.0566 18.6943
ES5 GDSC2 4.6838 6.9103 1.5715 0.9433
EW-13 GDSC2 4.7275 6.6008 1.706 0.4946
CHSA8926 GDSC2 4.7277 18.0287 -3.6278 23.8266
ES4 GDSC2 4.7784 10.4258 0.0884 8.1875
EW-7 GDSC2 4.8237 15.2526 -2.1956 18.7714
EW-18 GDSC2 4.9352 6.8298 1.7037 0.4081
H-EMC-SS GDSC2 5.0974 7.9946 1.3299 1.5208
CAL-72 GDSC2 5.1116 6.9815 1.7161 0.3161
HuO9 GDSC2 5.1554 7.2785 1.6268 0.5032
ES6 GDSC2 5.346 7.387 1.6603 0.3527
NY GDSC2 5.6139 16.3426 -2.1708 17.0381
G-292 clone A141B1 GDSC2 6.1792 15.6157 -1.4511 13.0353
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FLO-1 GDSC2 3.5647 6.1201 1.3315 3.4454
OACM5.1 C GDSC2 4.0074 14.4504 -2.4013 21.4056
KYSE-220 GDSC2 4.0639 6.8536 1.2903 2.8781
ESO-26 GDSC2 4.2368 6.0695 1.7028 0.803
KYSE-50 GDSC2 4.5015 6.2504 1.7449 0.5006
ESO-51 GDSC2 4.7619 6.652 1.7008 0.4919
OACP4 C GDSC2 4.8107 6.9905 1.5947 0.7787
KYAE-1 GDSC2 4.8499 6.8734 1.6545 0.5755
TE-12 GDSC2 4.9305 13.3264 -1.1874 14.2802
SK-GT-4 GDSC2 5.3695 7.5028 1.6281 0.4134
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 3.3427 6.4014 1.0574 5.4746
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-DZ GDSC2 2.7891 6.0507 0.8311 8.152
CHP-134 GDSC2 3.2551 5.3443 1.4995 3.0371
NB(TU)1 GDSC2 3.2868 5.3823 1.5016 2.9681
GOTO GDSC2 3.2924 6.2684 1.0872 5.4017
KP-N-YN GDSC2 3.3899 12.9021 -2.1066 21.813
IMR-5 GDSC2 3.4982 7.2533 0.7543 6.9566
CHP-212 GDSC2 3.586 9.2653 -0.1609 12.0698
SJNB-13 GDSC2 3.637 11.565 -1.2546 17.5422
SJNB-10 GDSC2 3.8916 7.4061 0.9385 5.0974
SJNB-7 GDSC2 3.9924 5.9672 1.6315 1.3065
TGW GDSC2 4.3124 5.8242 1.8262 0.3724
Kelly GDSC2 4.3624 5.66 1.9033 0.1843
SiMa GDSC2 4.3773 6.662 1.5316 1.3536
SK-N-AS GDSC2 4.5426 15.9065 -2.7202 21.3192
SJNB-14 GDSC2 4.5856 6.0384 1.8529 0.2128
SK-N-BE(2)-M17 GDSC2 4.6313 6.6701 1.6411 0.7424
GI-ME-N GDSC2 4.6437 8.1335 1.0469 3.3159
NH-12 GDSC2 5.3151 7.2546 1.6953 0.2934
NB69 GDSC2 5.9346 20.6855 -4.051 22.6077
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 4.5476 6.3206 1.7374 0.4979
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HDQ-P1 GDSC2 2.882 5.1905 1.3233 4.8678
BT-20 GDSC2 3.084 5.1386 1.4868 3.4388
CAMA-1 GDSC2 3.1398 12.4995 -2.1023 22.4508
MDA-MB-468 GDSC2 3.274 5.7471 1.323 4.0326
Evsa-T GDSC2 3.2873 5.0842 1.6382 2.1981
OCUB-M GDSC2 3.3678 13.6925 -2.5169 23.4054
HCC38 GDSC2 3.3812 5.6802 1.422 3.2545
HCC1428 GDSC2 3.5744 5.063 1.801 0.994
CAL-85-1 GDSC2 3.5784 6.5306 1.1498 4.4614
BT-474 GDSC2 3.5791 6.1707 1.317 3.502
MDA-MB-453 GDSC2 3.7447 8.578 0.2856 9.1726
HCC1419 GDSC2 3.8373 13.9863 -2.3006 21.4383
HCC2157 GDSC2 3.9966 5.8954 1.6628 1.1668
HCC1569 GDSC2 4.0012 6.6867 1.3291 2.7663
CAL-120 GDSC2 4.0025 10.528 -0.4789 12.818
DU4475 GDSC2 4.0583 5.4699 1.8554 0.4182
CAL-51 GDSC2 4.1805 7.0653 1.2614 2.8623
MDA-MB-157 GDSC2 4.1883 6.9296 1.3246 2.5303
EFM-192A GDSC2 4.2262 12.9531 -1.5023 17.248
MFM-223 GDSC2 4.2382 10.643 -0.3702 11.7211
HCC1937 GDSC2 4.2697 13.7769 -1.8745 18.7327
JIMT-1 GDSC2 4.2734 6.3506 1.6085 1.1334
Hs 578T GDSC2 4.2997 8.4169 0.7225 5.5837
ZR-75-30 GDSC2 4.3455 10.6651 -0.3075 11.1598
MRK-nu-1 GDSC2 4.385 5.8528 1.8439 0.2987
MDA-MB-361 GDSC2 4.4939 6.3623 1.7001 0.6388
HCC1500 GDSC2 4.4987 6.711 1.5677 1.1008
AU565 GDSC2 4.5189 11.6429 -0.6591 12.6066
HCC1187 GDSC2 4.5533 6.3651 1.7233 0.5351
BT-549 GDSC2 4.5775 7.0287 1.4772 1.3918
MDA-MB-415 GDSC2 4.6494 6.5655 1.6878 0.5866
MCF-7 GDSC2 4.679 7.505 1.3314 1.9147
MDA-MB-330 GDSC2 4.7448 13.8653 -1.5764 16.4103
HCC1954 GDSC2 4.941 6.8287 1.7063 0.3995
HCC1806 GDSC2 4.9866 13.8507 -1.4013 15.129
EFM-19 GDSC2 5.0485 7.5025 1.5002 0.9352
HCC70 GDSC2 5.049 7.3922 1.5422 0.7989
COLO 824 GDSC2 5.1946 7.0719 1.715 0.2921
MDA-MB-231 GDSC2 5.2157 7.1697 1.6885 0.3381
MDA-MB-436 GDSC2 5.2652 7.3385 1.6472 0.4096
HCC1143 GDSC2 5.3707 12.0303 -0.288 9.0676
T-47D GDSC2 5.4737 7.5255 1.6588 0.3152
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF268 GDSC2 2.9076 6.9139 0.4939 9.9227
U-87MG ATCC GDSC2 2.9365 7.1634 0.3924 10.464
KS-1 [Human Krukenberg tumour] GDSC2 3.0068 6.9559 0.548 9.3427
GB-1 GDSC2 3.3248 7.1052 0.7057 7.6297
Becker GDSC2 3.4133 5.6062 1.4756 2.8939
LN-18 GDSC2 3.424 10.7312 -1.0033 16.8829
AM-38 GDSC2 3.5237 11.2617 -1.1902 17.5257
LN-405 GDSC2 3.7811 5.955 1.5289 2.0459
U-118MG GDSC2 3.848 5.6195 1.7045 1.1353
SK-MG-1 GDSC2 3.8913 5.7074 1.6893 1.1575
8-MG-BA GDSC2 3.8938 6.4842 1.3588 2.7676
DK-MG GDSC2 3.9825 5.2305 1.9132 0.2984
D-263MG GDSC2 4.0384 5.9677 1.6532 1.1668
GI-1 GDSC2 4.0584 6.6124 1.3926 2.3618
KALS-1 GDSC2 4.1877 9.1889 0.2911 8.2119
D283 Med GDSC2 4.2399 5.5138 1.9095 0.2091
M059J GDSC2 4.3795 6.309 1.6721 0.808
KINGS-1 GDSC2 4.5509 12.8149 -1.2031 15.1643
GaMG GDSC2 4.5805 6.72 1.6002 0.9165
D-392MG GDSC2 4.6802 12.5841 -1.0016 13.9391
YH-13 GDSC2 4.6875 6.4614 1.741 0.4214
CAS-1 GDSC2 4.6927 6.2511 1.8179 0.2472
DBTRG-05MG GDSC2 4.7636 6.5332 1.7445 0.3808
U-251MG GDSC2 4.7778 6.2307 1.8556 0.1598
PFSK-1 GDSC2 4.859 6.4853 1.797 0.2372
Daoy GDSC2 4.8784 6.4896 1.8025 0.222
A-172 GDSC2 4.9327 6.6725 1.7586 0.2886
ONS-76 GDSC2 4.9594 6.6271 1.7842 0.2322
T98G GDSC2 4.9695 6.7574 1.7424 0.3094
LN-229 GDSC2 5.0245 6.5461 1.8349 0.1389
H4 GDSC2 5.0853 18.0175 -3.359 22.2565
SW1088 GDSC2 5.3239 6.9861 1.7904 0.1422
42-MG-BA GDSC2 5.5477 13.9933 -1.0942 12.6242
SF539 GDSC2 6.2812 18.7012 -2.8492 18.2267
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 3.965 7.0979 1.1245 3.924
ETK-1 GDSC2 3.9708 7.135 1.1111 3.9881
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-296 GDSC2 3.5048 6.8119 0.9697 5.6626
KLE GDSC2 3.7378 14.0928 -2.4292 22.1597
MFE-280 GDSC2 4.0007 7.0217 1.1798 3.5632
RL95-2 GDSC2 4.0246 7.7867 0.8445 5.3896
MFE-319 GDSC2 4.7388 6.1762 1.8604 0.1613
ESS-1 GDSC2 4.8107 6.6195 1.7315 0.3924
AN3-CA GDSC2 4.9776 7.0074 1.6559 0.5089
EN GDSC2 7.0846 24.1467 -4.9213 22.8288
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 128 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCI-AML-3 GDSC2 2.0385 10.7003 -2.1057 25.6128
RPMI-8226 GDSC2 2.2372 3.991 1.4158 5.9883
SUP-HD1 GDSC2 2.3823 4.3034 1.381 5.7838
ML-2 GDSC2 2.6184 12.6724 -2.6084 25.7309
ST486 GDSC2 2.6886 4.3737 1.5832 3.7129
BALL-1 GDSC2 2.7156 4.6521 1.4664 4.3738
Karpas-422 GDSC2 2.7867 4.5022 1.5907 3.4404
Jiyoye GDSC2 2.8063 9.2648 -0.7546 17.2845
DEL GDSC2 2.811 4.9637 1.3831 4.664
A3/Kawakami GDSC2 2.837 4.1728 1.7825 2.1759
OPM-2 GDSC2 2.8835 4.9209 1.4555 4.0524
VL51 GDSC2 2.9169 6.2707 0.8187 7.9062
U266B1 GDSC2 2.9303 5.5058 1.2041 5.4914
KMS-12-BM GDSC2 3.041 6.1279 0.9799 6.6137
Ramos.2G6.4C10 GDSC2 3.068 16.3014 -4.0562 28.8333
SR GDSC2 3.0862 5.5325 1.3002 4.5547
CML-T1 GDSC2 3.0922 6.1982 0.9822 6.4806
SCC-3 GDSC2 3.1229 4.7452 1.6949 2.1572
A4/Fukuda GDSC2 3.1485 7.7718 0.2514 10.7687
MOLP-8 GDSC2 3.1512 4.8492 1.6643 2.2809
L-428 GDSC2 3.1585 6.674 0.7975 7.4557
Reh GDSC2 3.1622 5.3008 1.461 3.4369
HAL-01 GDSC2 3.1709 5.3536 1.4418 3.5334
HEL GDSC2 3.1863 4.5446 1.8214 1.3696
MM1.S GDSC2 3.1984 4.8176 1.7067 1.9653
OCI-AML-5 GDSC2 3.1987 5.1627 1.5488 2.8561
CCRF-CEM GDSC2 3.2335 5.2756 1.518 2.9702
NCI-H929 GDSC2 3.2433 12.1707 -1.8573 21.1947
NOMO-1 GDSC2 3.2645 4.9841 1.6702 2.0595
BL-41 GDSC2 3.2664 4.8652 1.7244 1.7629
KM-H2 GDSC2 3.2798 5.1414 1.6078 2.3791
OCI-AML-2 GDSC2 3.2812 4.633 1.8339 1.1785
EoL-1 GDSC2 3.3334 5.0327 1.6878 1.8575
GDM-1 GDSC2 3.3421 5.6881 1.394 3.4866
697 GDSC2 3.3455 5.0729 1.6767 1.8981
U-698-M GDSC2 3.3869 6.2715 1.1485 4.8407
MN-60 GDSC2 3.3905 5.566 1.4803 2.9064
Namalwa GDSC2 3.4029 9.8355 -0.5765 14.7706
CA46 GDSC2 3.4571 6.0666 1.2899 3.8762
BE-13 GDSC2 3.4697 5.9973 1.3299 3.6226
H9 GDSC2 3.5547 8.0652 0.4015 8.9207
LAMA-84 GDSC2 3.5587 11.1335 -1.1004 17.0105
SKM-1 GDSC2 3.5799 10.4521 -0.7483 15.2181
BC-1 GDSC2 3.6241 5.5296 1.6292 1.7504
HC-1 GDSC2 3.6404 8.0372 0.4744 8.3032
MOLT-16 GDSC2 3.6509 5.9696 1.4504 2.6456
SU-DHL-10 GDSC2 3.6617 4.7326 1.9687 0.3034
KY821 GDSC2 3.6938 5.4115 1.7152 1.2513
RPMI-6666 GDSC2 3.7101 10.1237 -0.4912 13.5656
MLMA GDSC2 3.7476 6.2033 1.4012 2.7615
Ku812 GDSC2 3.7496 6.1263 1.4366 2.5698
Karpas-45 GDSC2 3.7507 5.7561 1.5986 1.7384
L-1236 GDSC2 3.7611 10.1899 -0.4867 13.4202
Kasumi-1 GDSC2 3.7641 5.7652 1.6016 1.7064
L-540 GDSC2 3.776 16.7534 -3.7207 26.2273
SK-MM-2 GDSC2 3.7892 5.9193 1.5487 1.9356
Karpas-299 GDSC2 3.8025 7.731 0.7294 6.4741
DoHH2 GDSC2 3.8266 4.997 1.9371 0.3081
CESS GDSC2 3.8479 5.8485 1.6094 1.5671
Karpas-1106P GDSC2 3.8517 5.715 1.667 1.297
Granta-519 GDSC2 3.8547 5.9908 1.5525 1.8327
MEG-01 GDSC2 3.8678 8.325 0.4903 7.7276
Karpas-620 GDSC2 3.8843 5.8653 1.6206 1.4726
GA-10 GDSC2 3.8936 5.4197 1.8053 0.6898
KE-37 GDSC2 3.9006 5.223 1.8833 0.4231
ME1 GDSC2 3.9472 5.1118 1.9423 0.2422
Karpas-231 GDSC2 3.9866 5.6354 1.762 0.7777
SU-DHL-5 GDSC2 3.9876 5.1806 1.9331 0.2478
RS4;11 GDSC2 3.9945 5.7131 1.735 0.8744
RC-K8 GDSC2 4.0057 5.3964 1.8614 0.4294
JJN-3 GDSC2 4.0104 5.7274 1.7365 0.8553
NALM-6 GDSC2 4.0135 13.8779 -2.114 20.2963
WIL2 NS GDSC2 4.0137 5.7961 1.7108 0.9532
Raji GDSC2 4.0191 5.7533 1.7302 0.8724
PF-382 GDSC2 4.0213 5.9807 1.6398 1.2407
JURL-MK1 GDSC2 4.0297 5.9978 1.6369 1.2452
P12-Ichikawa GDSC2 4.0395 12.9032 -1.6145 18.1756
RPMI-8866 GDSC2 4.0491 5.5394 1.8257 0.5134
SUP-M2 GDSC2 4.0838 5.4224 1.883 0.3301
OCI-M1 GDSC2 4.1082 5.3411 1.9215 0.2287
EJM GDSC2 4.1097 5.8938 1.7154 0.8549
P30/OHK GDSC2 4.1263 5.8903 1.7241 0.8092
K-562 GDSC2 4.1693 6.8074 1.3673 2.3424
P32/ISH GDSC2 4.171 5.643 1.8367 0.4125
EB2 GDSC2 4.1794 6.1075 1.6623 1.0014
VAL GDSC2 4.2197 25.6169 -7.7842 33.3573
IM-9 GDSC2 4.226 5.5554 1.8897 0.2555
ALL-PO GDSC2 4.2319 14.8099 -2.4105 20.9123
HL-60 GDSC2 4.2521 5.6033 1.8825 0.2618
AMO1 GDSC2 4.2591 5.8234 1.8054 0.4553
SU-DHL-8 GDSC2 4.2697 5.5682 1.9015 0.2157
KG-1 GDSC2 4.2787 6.4096 1.5873 1.215
JVM-2 GDSC2 4.2862 6.6079 1.5103 1.5354
ALL-SIL GDSC2 4.3027 5.7689 1.8425 0.3356
GR-ST GDSC2 4.3054 6.6244 1.5127 1.5048
Farage GDSC2 4.3149 5.9034 1.7982 0.4466
TUR GDSC2 4.3304 5.8057 1.8399 0.3301
ARH-77 GDSC2 4.3339 5.8454 1.8269 0.361
MHH-PREB-1 GDSC2 4.3382 5.8906 1.8121 0.3973
JVM-3 GDSC2 4.3408 6.1287 1.7246 0.656
Loucy GDSC2 4.345 5.8728 1.8213 0.3702
MHH-CALL-2 GDSC2 4.3475 5.9333 1.8002 0.4248
WSU-NHL GDSC2 4.3726 6.0699 1.7598 0.5267
DND-41 GDSC2 4.3783 6.0782 1.759 0.5259
DB GDSC2 4.3801 6.9152 1.4291 1.7976
SU-DHL-6 GDSC2 4.4267 6.3685 1.6695 0.7836
KOPN-8 GDSC2 4.4569 6.2944 1.7104 0.629
EM-2 GDSC2 4.4711 6.0646 1.8007 0.3664
TK [Human B-cell lymphoma] GDSC2 4.4852 6.1977 1.7578 0.4727
SUP-T1 GDSC2 4.5102 6.2792 1.7377 0.5164
HH [Human lymphoma] GDSC2 4.5259 6.5251 1.6518 0.7761
Daudi GDSC2 4.538 5.7733 1.9268 0.1085
KMOE-2 GDSC2 4.5493 6.2681 1.7574 0.4425
Hs 445 GDSC2 4.554 6.0252 1.846 0.2354
DG-75 GDSC2 4.5789 6.4102 1.7169 0.5398
SUP-B15 GDSC2 4.6786 6.5551 1.7033 0.5262
MOLM-13 GDSC2 4.7124 6.3507 1.7902 0.2972
LC4-1 GDSC2 4.7192 6.7326 1.6539 0.6486
LP-1 GDSC2 4.7329 6.2361 1.8377 0.1995
MOLT-13 GDSC2 4.7346 6.363 1.7941 0.2814
ATN-1 GDSC2 4.7666 6.3329 1.8163 0.2282
MOLT-4 GDSC2 4.8521 6.4419 1.8095 0.2167
JSC-1 GDSC2 4.9285 6.7466 1.7308 0.3485
Jurkat GDSC2 4.9339 6.5074 1.8163 0.1849
KCL-22 GDSC2 5.0439 6.6944 1.7913 0.1985
L-363 GDSC2 5.2868 23.8432 -6.0787 28.5703
HDLM-2 GDSC2 5.4852 7.4635 1.6845 0.2653
CTV-1 GDSC2 5.9621 18.6517 -3.0444 19.4885
⏷ Show the Full List of 128 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RCC10RGB GDSC2 2.8749 4.7689 1.523 3.6588
ACHN GDSC2 3.1501 5.3326 1.4382 3.5955
SW13 GDSC2 3.2062 5.3876 1.4485 3.4258
SN12C GDSC2 3.4528 8.8748 -0.0664 11.86
A-704 GDSC2 3.5113 5.732 1.4765 2.7253
BFTC-909 GDSC2 3.7315 5.6115 1.6502 1.512
769-P GDSC2 3.8053 7.2035 0.9788 5.0256
A-498 GDSC2 3.9433 8.9896 0.2234 9.099
HA7-RCC GDSC2 4.0189 9.5301 0.0153 10.1059
KTCTL-195 GDSC2 4.2576 12.5961 -1.3049 16.29
CAL-54 GDSC2 4.2759 7.6798 1.0429 3.8705
NCC010 GDSC2 4.2861 7.1297 1.2903 2.573
OS-RC-2 GDSC2 4.5078 6.3812 1.6987 0.6349
KMRC-20 GDSC2 4.8167 6.3551 1.8268 0.1964
TK-10 GDSC2 4.977 7.6813 1.3997 1.351
LB996-RCC GDSC2 5.0519 8.4008 1.1434 2.3556
RXF 393L GDSC2 5.1112 13.1602 -0.986 12.9738
786-O GDSC2 5.2437 7.5545 1.5607 0.6364
VMRC-RCZ GDSC2 5.4058 13.731 -1.0626 12.7513
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GP5d GDSC2 3.1512 5.8399 1.1969 5.0408
SNU-C1 GDSC2 3.3514 5.5958 1.4426 3.1895
RKO GDSC2 3.4051 5.7525 1.4033 3.3185
SW1116 GDSC2 3.4647 8.0487 0.346 9.4516
HT115 GDSC2 3.5694 12.6589 -1.8473 20.3126
KM12 GDSC2 3.6238 6.8378 1.0348 5.0438
HT-55 GDSC2 3.7877 5.4985 1.7251 1.107
CaR-1 GDSC2 3.8678 6.5018 1.3363 2.9257
HCT 15 GDSC2 3.905 9.4336 -0.0167 10.5332
HCT 116 GDSC2 3.9603 5.6265 1.7538 0.8301
SNU-61 GDSC2 3.9972 10.4238 -0.432 12.5834
LS513 GDSC2 4.0438 5.8061 1.7204 0.8895
HCC2998 GDSC2 4.1588 9.8244 -0.031 10.0625
SW1463 GDSC2 4.1741 6.7937 1.3757 2.2948
LoVo GDSC2 4.1851 11.6346 -0.8878 14.4795
SNU-C5 GDSC2 4.1926 12.0189 -1.0698 15.3426
SW948 GDSC2 4.2325 6.0073 1.725 0.7276
SW1417 GDSC2 4.243 6.478 1.5427 1.4379
MDST8 GDSC2 4.3441 5.7582 1.8621 0.2731
DiFi GDSC2 4.4079 7.4477 1.2177 2.7742
SW837 GDSC2 4.4143 7.3238 1.2743 2.487
HT-29 GDSC2 4.4186 5.8082 1.8722 0.2265
SNU-81 GDSC2 4.4383 6.1652 1.751 0.5165
COLO205 GDSC2 4.4538 5.7852 1.893 0.1777
LS123 GDSC2 4.4671 6.2072 1.747 0.5127
RCM-1 [Human ESC] GDSC2 4.4733 6.1847 1.7578 0.4787
LS411N GDSC2 4.5309 5.6827 1.9547 0.0772
LS180 GDSC2 4.5479 6.3146 1.7397 0.4912
SW626 GDSC2 4.5632 12.5796 -1.0804 14.5644
SNU-1040 GDSC2 4.5816 6.0985 1.8305 0.2576
LS1034 GDSC2 4.6597 6.139 1.8449 0.2066
COLO 320HSR GDSC2 4.6903 6.6974 1.6552 0.6614
SNU-175 GDSC2 4.6943 6.5152 1.7241 0.462
COLO 678 GDSC2 4.7351 7.2364 1.4665 1.295
SK-CO-1 GDSC2 4.7528 6.2891 1.8265 0.2137
CCK-81 GDSC2 4.8567 7.0855 1.5779 0.804
SNU-407 GDSC2 4.8826 6.7419 1.7151 0.4023
T84 GDSC2 4.8993 7.0816 1.5971 0.7175
C2BBe1 GDSC2 4.9387 6.9342 1.6673 0.4971
NCI-H716 GDSC2 4.9488 6.9382 1.6698 0.486
SW48 GDSC2 4.986 6.7828 1.7395 0.3099
CW-2 GDSC2 5.031 7.1595 1.6213 0.5758
NCI-H747 GDSC2 5.1276 7.1544 1.6608 0.4318
SNU-C2B GDSC2 5.1473 13.9868 -1.357 14.6002
SW620 GDSC2 5.2534 14.9536 -1.7493 16.0732
CL-11 GDSC2 5.4307 7.5745 1.6257 0.3965
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 4.1329 9.1689 0.2646 8.4715
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 GDSC2 2.7454 8.8961 -0.6193 16.7485
SK-HEP-1 GDSC2 2.9689 5.8101 1.0832 6.1464
HLE GDSC2 3.6218 11.973 -1.4678 18.5507
JHH-1 GDSC2 3.7015 10.0997 -0.4857 13.557
Huh-7 GDSC2 3.9152 5.8139 1.6572 1.2736
HuH-1 GDSC2 4.0996 5.504 1.8594 0.3856
Hep-G2/C3A GDSC2 4.3417 6.1138 1.7306 0.636
JHH-7 GDSC2 4.5211 7.6183 1.204 2.6952
SNU-449 GDSC2 4.5572 8.1774 0.9803 3.7785
Hep 3B2.1-7 GDSC2 4.6658 6.9444 1.5504 1.0327
JHH-4 GDSC2 4.9194 13.9615 -1.5011 15.7093
SNU-387 GDSC2 4.9333 7.4862 1.4568 1.1709
SNU-398 GDSC2 5.2682 12.5172 -0.5793 10.7068
JHH-2 GDSC2 5.3543 7.0366 1.784 0.145
SNU-423 GDSC2 5.5569 20.7217 -4.341 24.1191
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 129 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H526 GDSC2 2.3114 5.6555 0.6464 10.6171
NCI-H82 GDSC2 2.8049 5.6921 1.0204 6.9337
NCI-H1781 GDSC2 2.8875 11.7779 -1.9434 22.504
NCI-H1963 GDSC2 2.9894 5.753 1.1258 5.8363
Ms-1 GDSC2 3.0065 4.6306 1.676 2.4751
NCI-H345 GDSC2 3.0607 4.2321 1.8896 1.1945
SW1271 GDSC2 3.1105 7.6718 0.2723 10.7401
NCI-H720 GDSC2 3.1229 5.8663 1.1647 5.2972
NCI-H522 GDSC2 3.1691 5.7708 1.2422 4.7291
LOU-NH91 GDSC2 3.1778 5.4144 1.4175 3.6634
SHP-77 GDSC2 3.1818 9.0229 -0.3417 14.0735
COR-L311 GDSC2 3.1969 5.4824 1.3979 3.7419
NCI-H196 GDSC2 3.2795 4.8069 1.7575 1.5689
Calu-3 GDSC2 3.3136 10.8417 -1.1423 17.8382
NCI-H1092 GDSC2 3.3804 5.5689 1.4728 2.9664
NCI-H524 GDSC2 3.386 7.2051 0.7002 7.5251
HARA [Human squamous cell lung carcinoma] GDSC2 3.3966 5.2922 1.608 2.1892
NCI-H2795 GDSC2 3.4412 6.8122 0.9271 6.047
NCI-H1915 GDSC2 3.4452 5.3165 1.6247 2.0253
NCI-H2810 GDSC2 3.4485 6.4001 1.1279 4.8399
IA-LM GDSC2 3.4619 6.9413 0.8793 6.2885
UMC-11 GDSC2 3.4829 7.6588 0.5482 8.216
NCI-H1876 GDSC2 3.4879 5.3598 1.6293 1.9384
RERF-LC-KJ GDSC2 3.5252 6.8486 0.9657 5.6442
NCI-H2369 GDSC2 3.5287 5.1458 1.7436 1.3099
LC-1/sq GDSC2 3.5851 9.6584 -0.3542 13.1326
NCI-H446 GDSC2 3.6019 5.3822 1.6808 1.5234
DMS 79 GDSC2 3.6258 5.8208 1.5025 2.4048
HOP-92 GDSC2 3.66 7.3198 0.8308 6.1669
EPLC-272H GDSC2 3.6831 6.3476 1.2985 3.4279
NCI-H2373 GDSC2 3.7097 12.9961 -1.9073 20.208
VMRC-LCD GDSC2 3.7809 7.6046 0.7751 6.2509
DMS 53 GDSC2 3.8023 6.7279 1.1962 3.7978
NCI-H1048 GDSC2 3.8709 8.348 0.4815 7.7722
SBC-5 GDSC2 3.8719 4.8378 2.0108 0.128
NCI-H841 GDSC2 3.88 5.7438 1.6689 1.2585
NCI-H2087 GDSC2 3.8832 7.0618 1.0922 4.2419
NCI-H1568 GDSC2 3.8865 10.2371 -0.4197 12.7713
NCI-H2227 GDSC2 3.9064 12.627 -1.5771 18.3323
NCI-H3255 GDSC2 3.9133 7.7734 0.7809 5.96
NCI-H2029 GDSC2 3.9582 5.5214 1.794 0.6821
NCI-H211 GDSC2 3.9715 6.0609 1.5824 1.5508
NCI-H2023 GDSC2 4.0556 9.3983 0.1035 9.5355
NCI-H2141 GDSC2 4.0711 5.6884 1.7783 0.656
NCI-H1975 GDSC2 4.0717 6.2225 1.5647 1.5202
COR-L23 GDSC2 4.0815 6.0625 1.6351 1.2018
HCC366 GDSC2 4.1158 9.1873 0.2445 8.6192
NCI-H1869 GDSC2 4.1369 16.1181 -3.1282 23.6064
DMS 273 GDSC2 4.1531 5.7941 1.7727 0.6193
SK-LU-1 GDSC2 4.1851 8.2737 0.7183 5.811
NCI-H2731 GDSC2 4.2041 11.326 -0.7243 13.6236
NCI-H810 GDSC2 4.2062 5.755 1.8094 0.4722
NCI-H2122 GDSC2 4.2496 6.3945 1.5798 1.2734
NCI-H2135 GDSC2 4.2786 5.9546 1.7644 0.5672
NCI-H727 GDSC2 4.2821 8.5894 0.6321 6.1184
EKVX GDSC2 4.2982 9.061 0.4225 7.2599
NCI-H1694 GDSC2 4.3249 5.703 1.8744 0.2531
NCI-H3122 GDSC2 4.3444 6.9379 1.4019 1.9624
SK-MES-1 GDSC2 4.3669 6.4035 1.6298 0.9717
COLO 668 GDSC2 4.3735 6.5039 1.5931 1.1072
NCI-H209 GDSC2 4.3796 12.3117 -1.0793 14.9643
SBC-3 GDSC2 4.3828 6.1478 1.7348 0.597
IST-SL2 GDSC2 4.4049 6.9359 1.4327 1.7544
NCI-H358 GDSC2 4.4544 6.9 1.4713 1.5339
NCI-H596 GDSC2 4.4607 6.563 1.6089 0.9757
NCI-H1755 GDSC2 4.4671 7.8162 1.0894 3.3438
NCI-H1792 GDSC2 4.4799 6.8833 1.4902 1.429
NCI-H2461 GDSC2 4.4878 6.9974 1.4476 1.6027
Lu-139 GDSC2 4.49 6.0417 1.8162 0.3215
NCI-H250 GDSC2 4.5136 6.3931 1.6966 0.6379
NCI-H1993 GDSC2 4.5258 6.4139 1.6939 0.6391
NCI-H1155 GDSC2 4.5442 6.195 1.7819 0.3816
PC-14 GDSC2 4.5737 7.4941 1.2838 2.2488
HCC827 GDSC2 4.5756 6.3914 1.7225 0.5254
LK-2 GDSC2 4.612 6.6887 1.6258 0.8057
Lu-135 GDSC2 4.6217 6.681 1.6328 0.7757
NCI-H2803 GDSC2 4.6258 6.4954 1.7042 0.5514
NCI-H1435 GDSC2 4.6509 6.497 1.7137 0.5115
NCI-H322M GDSC2 4.6529 14.5788 -1.9892 18.3324
EMC-BAC-2 GDSC2 4.6573 7.0688 1.4977 1.239
NCI-H2085 GDSC2 4.6663 13.6071 -1.5064 16.2765
NCI-H1650 GDSC2 4.68 7.6155 1.2862 2.1171
NCI-H1355 GDSC2 4.6838 10.9907 -0.2374 10.0964
Lu-65 GDSC2 4.6913 6.6576 1.6705 0.6146
EBC-1 GDSC2 4.6963 11.4646 -0.4542 11.1961
NCI-H1651 GDSC2 4.703 11.8212 -0.6199 12.0233
NCI-H2804 GDSC2 4.7147 6.8441 1.61 0.7904
Calu-6 GDSC2 4.7178 6.9176 1.5833 0.8782
CPC-N GDSC2 4.7421 6.6409 1.697 0.5117
RERF-LC-Sq1 GDSC2 4.7563 7.4728 1.3815 1.6207
HCC44 GDSC2 4.7613 7.0486 1.5516 0.9576
HCC15 GDSC2 4.7669 6.6106 1.7178 0.4451
NCI-H2591 GDSC2 4.7712 11.3965 -0.3724 10.6251
HCC78 GDSC2 4.8229 12.3255 -0.7804 12.5719
NCI-H1944 GDSC2 4.8336 6.889 1.6421 0.6195
LXF 289 GDSC2 4.8514 7.5269 1.4039 1.4417
Lu-99A GDSC2 4.8863 7.0163 1.6162 0.667
Lu-165 GDSC2 4.8895 16.7633 -2.8868 21.1347
NCI-H2818 GDSC2 4.8896 6.9874 1.6283 0.6296
NCI-H441 GDSC2 4.9049 15.2254 -2.1244 18.3195
DMS 114 GDSC2 4.9089 6.7946 1.7063 0.4126
COR-L105 GDSC2 4.9574 12.1474 -0.6062 11.4405
NCI-H661 GDSC2 4.9596 7.5761 1.4333 1.2375
LCLC-97TM1 GDSC2 4.96 7.6337 1.4108 1.3223
NCI-H1563 GDSC2 4.9818 19.4442 -4.1362 24.7243
NCI-H2722 GDSC2 5.0979 6.9077 1.737 0.2794
NCI-H1623 GDSC2 5.1164 7.2317 1.6286 0.516
NCI-H1666 GDSC2 5.1226 14.0903 -1.4235 14.9453
A-427 GDSC2 5.1509 7.3329 1.6053 0.561
NCI-H520 GDSC2 5.1511 7.3456 1.6007 0.5732
HOP-62 GDSC2 5.1734 6.8716 1.7766 0.1914
NCI-H2869 GDSC2 5.1912 7.5197 1.5526 0.6867
NCI-H2170 GDSC2 5.2269 7.0726 1.7266 0.2613
NCI-H1793 GDSC2 5.2482 16.3772 -2.4415 18.8011
SW1573 GDSC2 5.2791 7.5856 1.5634 0.6116
NCI-H650 GDSC2 5.3411 17.7101 -3.0242 20.6511
NCI-H2228 GDSC2 5.3807 7.7273 1.5516 0.5944
NCI-H2405 GDSC2 5.43 11.0388 0.2003 6.4886
ABC-1 GDSC2 5.4565 16.2522 -2.2355 17.6013
NCI-H2595 GDSC2 5.4875 7.4649 1.6849 0.2641
NCI-H513 GDSC2 5.5971 7.6298 1.6674 0.2654
NCI-H1581 GDSC2 5.6227 18.3706 -3.1457 20.4842
NCI-H1693 GDSC2 5.7239 7.6867 1.6929 0.1967
NCI-H1299 GDSC2 5.7427 13.3098 -0.6503 10.1873
A-549 GDSC2 5.8209 14.5883 -1.198 12.582
NCI-H226 GDSC2 6.8468 22.3953 -4.2398 21.4687
NCI-H23 GDSC2 6.8557 21.1043 -3.6123 19.6465
KNS-62 GDSC2 7.0039 19.6681 -2.8283 16.8589
LCLC-103H GDSC2 7.3838 19.1625 -2.3465 14.509
⏷ Show the Full List of 129 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 3.646 6.446 1.2311 3.8719
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-6 GDSC2 2.6378 5.851 0.8133 8.6594
TE-4 GDSC2 3.5616 8.6894 0.1028 10.6382
TE-9 GDSC2 4.0908 5.8004 1.7436 0.7652
KYSE-70 GDSC2 4.1528 6.1717 1.6244 1.1787
KYSE-140 GDSC2 4.1558 7.4152 1.0925 3.7909
OE33 GDSC2 4.2021 7.9174 0.8924 4.8097
OE19 GDSC2 4.3433 5.7687 1.858 0.2824
KYSE-410 GDSC2 4.3928 14.4654 -2.1223 19.4439
COLO 680N GDSC2 4.4682 6.2878 1.7175 0.6002
OE21 GDSC2 4.535 8.6995 0.7341 5.1212
KYSE-450 GDSC2 4.5377 6.1509 1.7953 0.3517
KYSE-270 GDSC2 4.5917 7.1588 1.4313 1.5699
TE-8 GDSC2 4.5997 7.2194 1.4104 1.6511
TE-15 GDSC2 4.6695 7.3425 1.3934 1.6547
KYSE-520 GDSC2 4.7697 13.5175 -1.3904 15.5399
EC-GI-10 GDSC2 4.7912 7.5617 1.362 1.6693
TE-1 GDSC2 4.9732 7.3752 1.5168 0.9298
TE-5 GDSC2 5.0984 13.9406 -1.3681 14.75
KYSE-510 GDSC2 5.6724 25.5986 -6.6557 28.95
KYSE-180 GDSC2 7.4112 22.2805 -3.8011 19.2566
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OV56 GDSC2 2.8886 4.465 1.6779 2.6946
OAW42 GDSC2 3.4766 14.1531 -2.6611 23.6379
TOV-112D GDSC2 3.6258 6.233 1.3166 3.4239
TOV-21G GDSC2 3.8156 5.393 1.7808 0.8476
TYK-nu GDSC2 3.8984 8.6161 0.3719 8.3461
OVCAR-3 GDSC2 3.9093 5.7394 1.6849 1.1586
ES-2 GDSC2 4.1163 5.5182 1.8608 0.3734
OVISE GDSC2 4.1336 5.3987 1.9106 0.2432
OV-90 GDSC2 4.3713 11.478 -0.6812 13.0359
EFO-21 GDSC2 4.4792 9.6179 0.2768 7.7244
EFO-27 GDSC2 4.6874 15.7248 -2.525 20.3033
OVCAR-4 GDSC2 4.7004 7.0574 1.5215 1.1128
OVK18 GDSC2 4.728 6.1383 1.8695 0.1499
OVTOKO GDSC2 4.7492 9.0105 0.7184 4.8635
A2780 GDSC2 4.8513 6.8417 1.6667 0.5407
OAW28 GDSC2 4.9501 14.873 -1.9211 17.4128
SK-OV-3 GDSC2 4.9779 7.4055 1.5073 0.9589
OVCAR-5 GDSC2 5.1153 16.4686 -2.5802 19.5833
DOV13 GDSC2 5.1646 6.7244 1.8234 0.1287
Kuramochi GDSC2 5.2815 9.2032 0.9224 3.11
IGROV-1 GDSC2 5.3992 7.0489 1.7953 0.1241
OVCAR-8 GDSC2 5.4866 7.1053 1.8063 0.1001
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 02.03 GDSC2 3.2819 7.2896 0.5856 8.4515
YAPC GDSC2 3.4362 18.9598 -5.0877 30.3505
QGP-1 GDSC2 3.4737 6.0833 1.2925 3.8305
PaTu 8988t GDSC2 3.7731 21.2442 -5.9587 31.3273
PSN1 GDSC2 3.8849 5.5947 1.732 0.9831
HPAC GDSC2 3.8935 10.1498 -0.3722 12.5022
KP-4 GDSC2 3.9715 5.8051 1.6876 1.0863
MIA PaCa-2 GDSC2 4.1053 5.6273 1.8159 0.5104
CFPAC-1 GDSC2 4.2252 5.9905 1.7283 0.7213
PaTu 8902 GDSC2 4.3524 5.7172 1.8797 0.2327
HPAF-II GDSC2 4.3726 7.6674 1.1027 3.4099
SU.86.86 GDSC2 4.3922 5.6867 1.9049 0.1734
SUIT-2 GDSC2 4.4088 14.4151 -2.0859 19.2647
Capan-2 GDSC2 4.4358 6.7808 1.511 1.3841
KP-1N GDSC2 4.5131 7.3633 1.3082 2.2048
Capan-1 GDSC2 4.5357 6.2236 1.7682 0.4202
Panc 08.13 GDSC2 4.5447 6.9122 1.5087 1.2935
HuP-T4 GDSC2 4.5615 15.0677 -2.2945 19.7272
KP-2 GDSC2 4.5726 6.7434 1.5878 0.9672
HuP-T3 GDSC2 4.7119 6.3944 1.7744 0.3317
BxPC-3 GDSC2 4.7711 11.0277 -0.1983 9.7195
PL4 GDSC2 5.0885 6.7559 1.7861 0.1963
AsPC-1 GDSC2 5.214 13.2477 -0.9595 12.6448
KP-3 GDSC2 5.5188 7.5899 1.6528 0.3131
DAN-G GDSC2 5.6386 18.6765 -3.2832 20.8951
Panc 10.05 GDSC2 6.5198 22.6311 -4.5825 22.9561
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC2 4.1247 15.8638 -3.0115 23.2564
NCI-H2052 GDSC2 4.3693 12.1168 -0.9919 14.5704
NCI-H28 GDSC2 4.6099 10.4109 -0.0117 9.0429
MSTO-211H GDSC2 4.6489 6.7063 1.6347 0.7518
IST-Mes1 GDSC2 4.7585 6.9689 1.5809 0.8583
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC2 3.0268 10.7048 -1.2975 19.3304
PC-3 GDSC2 3.7968 7.2654 0.9446 5.2383
22Rv1 GDSC2 4.1114 6.1752 1.6035 1.3076
LNCaP clone FGC GDSC2 4.2094 6.7011 1.4334 1.9724
DU145 GDSC2 4.4978 6.6146 1.6051 0.961
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 4.454 6.1382 1.7672 0.4623
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-7951 GDSC2 3.0358 10.0107 -0.945 17.6165
GAK GDSC2 3.1536 5.174 1.5151 3.136
A2058 GDSC2 3.2456 7.5934 0.4108 9.5842
CHL-1 GDSC2 3.3578 5.8486 1.329 3.8353
M14 GDSC2 3.3908 5.954 1.3006 3.9383
SK-MEL-2 GDSC2 3.4678 12.2434 -1.7192 20.0346
WM278 GDSC2 3.5938 6.9554 0.9601 5.5401
WT2-iPS GDSC2 3.6051 8.5336 0.2096 9.9238
IGR-37 GDSC2 3.7341 5.2029 1.8193 0.7658
WM115 GDSC2 3.7956 5.3248 1.7988 0.7937
COLO 792 GDSC2 3.9454 8.3992 0.5065 7.4759
A101D GDSC2 3.9692 6.9707 1.1844 3.5881
WM1552C GDSC2 4.0269 6.7065 1.3345 2.7015
SK-MEL-5 GDSC2 4.0505 5.2061 1.9476 0.1937
IGR-1 GDSC2 4.0979 8.9136 0.3627 7.9886
WM35 GDSC2 4.1257 9.1299 0.2783 8.4086
WM793 GDSC2 4.1275 6.1339 1.6278 1.1882
CP66-MEL GDSC2 4.1686 5.6093 1.8481 0.3824
SH-4 GDSC2 4.2994 6.0038 1.7545 0.5856
Mel JuSo GDSC2 4.3264 5.7962 1.8418 0.3272
COLO 679 GDSC2 4.3305 6.0179 1.762 0.5441
LOX-IMVI GDSC2 4.3968 6.769 1.4973 1.4795
UACC-257 GDSC2 4.4529 6.1073 1.7781 0.4332
G-mel GDSC2 4.4736 6.0025 1.824 0.3101
UACC-62 GDSC2 4.4744 5.5122 1.992 0.0495
COLO 829 GDSC2 4.7594 6.8294 1.6341 0.6857
G-361 GDSC2 4.8915 11.9333 -0.548 11.2799
HMV-II GDSC2 5.1136 7.3206 1.595 0.6071
SK-MEL-24 GDSC2 5.2024 22.3895 -5.4241 27.3907
A-375 GDSC2 5.6674 15.9709 -1.956 16.0884
HT-144 GDSC2 6.9665 24.1161 -4.989 23.1949
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 4.2061 6.484 1.5224 1.5658
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EW-8 GDSC2 3.394 5.3212 1.5935 2.2722
SW872 GDSC2 3.4467 11.0409 -1.1393 17.4805
SW684 GDSC2 3.4508 11.9642 -1.5938 19.5396
SW982 GDSC2 3.6062 6.6671 1.1036 4.6771
Rh30 GDSC2 3.704 6.1917 1.3814 2.9366
VA-ES-BJ GDSC2 3.7716 10.0821 -0.4264 13.0756
HT-1080 GDSC2 3.9666 5.6587 1.7439 0.8633
RKN GDSC2 4.3745 5.5034 1.9611 0.0941
MES-SA GDSC2 4.3766 5.6942 1.8966 0.1925
G-402 GDSC2 4.4456 11.5616 -0.6702 12.8192
KYM-1 GDSC2 4.6097 13.7038 -1.5934 16.7792
A-204 GDSC2 4.8139 9.0551 0.7353 4.6753
SK-UT-1 GDSC2 5.0707 6.8161 1.7589 0.2466
RD GDSC2 5.092 7.493 1.522 0.8363
Rh41 GDSC2 5.1818 7.0388 1.7219 0.2829
SK-LMS-1 GDSC2 5.2595 15.4465 -1.9828 17.0141
GCT GDSC2 5.5041 15.8576 -2.0126 16.6373
G-401 GDSC2 5.7886 19.8692 -3.7573 22.0481
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-5 GDSC2 2.8857 4.6131 1.6053 3.1363
RF-48 GDSC2 3.0714 6.8953 0.6258 8.7095
NUGC-3 GDSC2 3.1145 12.5893 -2.1671 22.7691
ECC10 GDSC2 3.1585 9.3878 -0.5404 15.2082
MKN45 GDSC2 3.2691 13.4291 -2.4634 23.4673
NUGC-4 GDSC2 3.395 8.2594 0.1931 10.5101
HGC-27 GDSC2 3.6093 10.032 -0.5199 13.9603
KATO III GDSC2 3.7133 6.9182 1.054 4.7638
MKN1 GDSC2 3.9316 5.3785 1.8375 0.5498
GCIY GDSC2 3.9586 8.5165 0.4595 7.719
NCI-N87 GDSC2 3.9978 10.5961 -0.5153 13.0194
RERF-GC-1B GDSC2 4.0086 17.6284 -3.9751 26.3916
AGS GDSC2 4.1601 13.0093 -1.578 17.7334
IM95 GDSC2 4.2478 7.2263 1.2278 2.941
Hs 746.T GDSC2 4.4042 6.1025 1.7605 0.5075
OCUM-1 GDSC2 4.4055 15.6554 -2.6981 21.55
23132/87 GDSC2 4.6602 14.6893 -2.0379 18.5111
SK-GT-2 GDSC2 4.9215 6.8521 1.6904 0.4461
MKN28 GDSC2 4.9744 11.1426 -0.1225 8.9384
SNU-1 GDSC2 5.1841 7.0821 1.7076 0.3099
SNG-M GDSC2 4.0895 8.8299 0.3968 7.8118
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BHT-101 GDSC2 2.996 6.4372 0.7955 7.8552
ASH-3 GDSC2 3.3675 4.9971 1.7224 1.626
CAL-62 GDSC2 3.3787 5.0993 1.6836 1.8123
HTC-C3 GDSC2 3.8521 6.7779 1.2031 3.6759
B-CPAP GDSC2 3.8563 9.2275 0.0492 10.2724
FTC-133 GDSC2 3.9098 6.8867 1.1877 3.666
WRO GDSC2 3.9365 6.0006 1.5901 1.5549
K5 GDSC2 3.9516 9.77 -0.1469 11.15
8505C GDSC2 4.2536 13.4887 -1.7448 18.2301
IHH-4 GDSC2 4.5126 6.2171 1.7615 0.449
8305C GDSC2 4.598 5.9977 1.8715 0.177
TT2609-C02 GDSC2 5.225 7.2462 1.6649 0.3851
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-27 GDSC2 2.8165 4.9365 1.4004 4.5439
DOK GDSC2 2.9787 8.1185 -0.0489 12.9575
HO-1-N-1 GDSC2 3.0171 5.268 1.3803 4.2181
SCC-4 GDSC2 3.2459 12.053 -1.7967 20.9368
LB771-HNC GDSC2 3.3568 11.3931 -1.3827 18.8437
HSC-2 GDSC2 3.3742 6.2104 1.1692 4.7438
FaDu GDSC2 3.4022 12.438 -1.8665 20.8185
SCC-9 GDSC2 3.427 14.1619 -2.7042 23.9121
SAS GDSC2 3.5435 11.9031 -1.4926 18.8581
SCC-15 GDSC2 3.7038 6.2421 1.3586 3.0618
BICR 22 GDSC2 3.8594 11.1607 -0.8908 15.2535
Detroit 562 GDSC2 3.9164 11.9561 -1.2396 16.7891
Ca9-22 GDSC2 3.9267 6.8378 1.2197 3.4637
UPCI-SCC-090 GDSC2 3.9433 21.486 -5.9447 30.9472
HSC-4 GDSC2 4.2292 5.6221 1.8671 0.3065
HSC-3 GDSC2 4.3041 5.7424 1.8525 0.3106
NCI-H3118 GDSC2 4.3057 7.4955 1.1414 3.3052
BICR 78 GDSC2 4.3773 16.3004 -3.0371 22.7626
SKN-3 GDSC2 4.4861 10.9612 -0.3544 11.1113
JHU-022 GDSC2 4.508 12.5725 -1.1156 14.8508
OSC-20 GDSC2 4.5162 12.5393 -1.0937 14.7299
BB49-HNC GDSC2 4.5996 7.0693 1.4711 1.3963
PCI-04B GDSC2 4.7686 7.409 1.413 1.4793
CAL-33 GDSC2 5.0081 6.8432 1.7264 0.3296
SAT [Human HNSCC] GDSC2 5.4678 8.3282 1.3627 1.1161
BICR 10 GDSC2 5.685 18.1462 -2.9929 19.8561
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-905 GDSC2 3.232 7.5732 0.4107 9.6174
TCCSUP GDSC2 3.2777 7.1048 0.6727 7.9365
KU-19-19 GDSC2 3.435 7.2474 0.7138 7.3357
HT-1197 GDSC2 3.6873 5.6776 1.5989 1.8185
639V GDSC2 3.925 5.121 1.9305 0.2799
CAL-29 GDSC2 4.0803 5.7688 1.7512 0.7452
SW1710 GDSC2 4.2196 10.0739 -0.1093 10.3621
RT-4 GDSC2 4.2357 17.6158 -3.7945 25.3831
647V GDSC2 4.5276 5.7729 1.9233 0.1149
RT-112 GDSC2 4.7622 6.1496 1.8777 0.1315
5637 GDSC2 5.0388 7.7223 1.4111 1.2578
SW780 GDSC2 5.5171 19.404 -3.7248 22.4846
J82 GDSC2 6.879 18.6507 -2.4287 15.6617
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC2 2.5338 5.4169 0.9473 8.1013
OVCA420 GDSC2 2.7146 5.2666 1.1627 6.2725
HEC-1 GDSC2 2.8586 11.0034 -1.5801 21.0626
HeLa GDSC2 2.9452 12.3623 -2.1887 23.3072
NEC8 GDSC2 3.25 6.3849 1.0022 6.005
DSH1 GDSC2 3.4489 6.5383 1.0628 5.2243
PEO1 GDSC2 3.5089 7.1187 0.8261 6.5063
HT-3 GDSC2 3.5399 6.8892 0.9561 5.6715
MS751 GDSC2 3.589 6.3039 1.2617 3.7987
SKN GDSC2 3.8127 16.7605 -3.6957 26.0705
ME-180 GDSC2 3.8382 6.366 1.38 2.7378
SiSo GDSC2 4.0272 14.6601 -2.4901 21.6842
CAL-39 GDSC2 4.2643 6.5118 1.5391 1.432
DoTc2 4510 GDSC2 4.292 6.9045 1.3895 2.0824
LB831-BLC GDSC2 4.3301 7.1055 1.3237 2.352
OVMIU GDSC2 4.439 7.4741 1.2229 2.7081
PWR-1E GDSC2 4.4464 6.2252 1.7319 0.5687
SW756 GDSC2 4.5554 15.3174 -2.4214 20.2163
BPH-1 GDSC2 4.6281 10.8627 -0.2133 10.0803
C-4-I GDSC2 4.7761 6.9044 1.6128 0.7424
TC-YIK GDSC2 4.8327 6.6468 1.7302 0.3867
HEY GDSC2 4.9576 7.4332 1.4879 1.0404
C-33 A GDSC2 5.1483 7.1205 1.6807 0.3783
Ca Ski GDSC2 5.3885 8.053 1.4339 0.9336
SiHa GDSC2 5.7319 21.9888 -4.8347 25.0322
SKG-IIIa GDSC2 5.9337 20.5111 -3.9666 22.3726
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7529).
2 Bromodomains and their pharmacological inhibitors. ChemMedChem. 2014 Mar;9(3):438-64.
3 CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10768-73. doi: 10.1073/pnas.1501956112. Epub 2015 Aug 10.