Details of the Drug

General Information of Drug (ID: DMTM4QA)

Drug Name
LCL161
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Phase 2 [1]
Myelofibrosis 2A20.2 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Breast cancer 2C60-2C65 Phase 1 [1]
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 500.6
Logarithm of the Partition Coefficient (xlogp) 4.3
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C26H33FN4O3S
IUPAC Name
(2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamide
Canonical SMILES
C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC
InChI
InChI=1S/C26H33FN4O3S/c1-16(28-2)24(33)30-22(17-7-4-3-5-8-17)26(34)31-14-6-9-21(31)25-29-20(15-35-25)23(32)18-10-12-19(27)13-11-18/h10-13,15-17,21-22,28H,3-9,14H2,1-2H3,(H,30,33)/t16-,21-,22-/m0/s1
InChIKey
UFPFGVNKHCLJJO-SSKFGXFMSA-N
Cross-matching ID
PubChem CID
24737642
CAS Number
1005342-46-0
UNII
6TNS415Y3P
DrugBank ID
DB12085
TTD ID
D09MIN
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Inhibitor of apoptosis protein (hIAP) TTS74QB XIAP_HUMAN ; BIRC2_HUMAN ; BIRC3_HUMAN ; BIRC1_HUMAN ; BIRC7_HUMAN ; BIRC5_HUMAN Modulator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Gene/Protein Processing [4]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 3.8327 5.9047 0.669 0.8231
ES1 GDSC1 3.0558 5.2227 0.5883 2.0232
CHSA8926 GDSC1; GDSC2 3.9348 7.5643 1.6873 8.6707
EW-18 GDSC1; GDSC2 4.3138 14.6558 -1.5411 23.6291
SK-PN-DW GDSC1; GDSC2 4.5724 6.7766 2.4918 2.5436
CADO-ES1 GDSC1; GDSC2 4.6502 7.7428 2.0961 4.6379
CAL-72 GDSC1; GDSC2 4.6512 10.0151 1.008 10.9686
SJSA-1 GDSC1 4.7361 14.2459 -2.5363 16.6313
CAL-78 GDSC1; GDSC2 4.9472 7.6883 2.2983 3.0083
EW-3 GDSC1; GDSC2 5.0482 10.8076 0.9018 10.6689
EW-7 GDSC1; GDSC2 5.0723 7.3354 2.5179 1.735
EW-13 GDSC1; GDSC2 5.1083 7.3876 2.5141 1.7114
HuO9 GDSC1; GDSC2 5.1686 10.0745 1.3328 8.0151
TC-71 GDSC1; GDSC2 5.2451 7.0295 2.7218 0.7297
ES4 GDSC1; GDSC2 5.3696 7.5481 2.5737 1.1876
HOS GDSC1; GDSC2 5.528 7.0476 2.8285 0.28
MG-63 GDSC1; GDSC2 5.5301 7.1956 2.7762 0.4023
EW-11 GDSC2 5.5314 10.9511 1.154 8.2976
EW-1 GDSC1; GDSC2 5.5728 7.5246 2.6716 0.6806
EW-12 GDSC2 5.5781 7.3476 2.7396 0.4764
EW-24 GDSC1; GDSC2 5.5892 7.2315 2.7861 0.3527
ES5 GDSC1; GDSC2 5.6021 8.8612 2.1424 2.8942
U-CH2 GDSC2 5.7319 7.7586 2.6493 0.6551
SK-ES-1 GDSC1; GDSC2 5.8001 7.3221 2.8322 0.1915
ES6 GDSC1; GDSC2 5.8077 8.0372 2.5757 0.8429
EW-22 GDSC1; GDSC2 5.812 7.7132 2.6982 0.4752
CHSA0011 GDSC2 5.8151 8.3027 2.4762 1.1914
G-292 clone A141B1 GDSC1; GDSC2 5.901 10.5465 1.5652 5.433
CHSA0108 GDSC2 5.9025 17.0955 -1.5506 19.9286
EW-16 GDSC1; GDSC2 5.9228 16.1818 -1.0905 18.1472
HuO-3N1 GDSC1; GDSC2 6.0342 8.7364 2.4035 1.2898
ES7 GDSC1; GDSC2 6.1528 8.3683 2.593 0.5929
NY GDSC1; GDSC2 6.2114 9.9497 1.9936 2.8602
ES8 GDSC1; GDSC2 6.3321 14.2673 0.1086 12.0927
SaOS-2 GDSC1; GDSC2 6.3614 15.4705 -0.4441 14.5521
H-EMC-SS GDSC1; GDSC2 6.4209 9.068 2.4417 0.8892
A-673 GDSC1; GDSC2 6.5825 10.7774 2.7267 4.6319
U2OS GDSC1; GDSC2 6.7509 9.9991 3.1608 2.3821
NOS-1 [Human HNSCC] GDSC1; GDSC2 7.7117 19.4539 -1.4446 16.012
MHH-ES-1 GDSC1; GDSC2 8.7935 17.4979 0.1071 8.112
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 167 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 5.8255 7.4974 2.7805 0.2792
NB4 GDSC1; GDSC2 -3.5034 2.924 -4.022 62.5748
VL51 GDSC1; GDSC2 -2.2604 0.7118 -2.3034 55.7111
MOLT-16 GDSC1; GDSC2 -0.9784 4.0125 -1.5764 44.5401
MHH-CALL-4 GDSC2 1.3668 4.0213 0.9634 21.7963
Karpas-299 GDSC1 1.7854 3.8808 0.4312 5.8777
Sc-1 GDSC1 2.7243 4.9298 0.5396 2.8575
CTV-1 GDSC1; GDSC2 2.8119 5.1976 1.9312 10.4069
RL GDSC1; GDSC2 3.0912 6.111 1.7308 10.7534
WSU-DLCL2 GDSC1 3.1057 9.7313 -1.4781 15.2986
YT GDSC1 3.2929 5.1385 0.7331 0.9977
SU-DHL-16 GDSC1; GDSC2 3.3114 5.3941 2.277 6.6457
EHEB GDSC1 3.3541 5.3712 0.6692 1.2331
SUP-M2 GDSC1; GDSC2 3.3766 6.0378 2.0092 8.1501
MC116 GDSC1; GDSC2 3.5273 7.6523 1.3254 11.9721
SCC-3 GDSC1; GDSC2 3.6812 5.8269 2.3548 5.1543
MOLM-13 GDSC1; GDSC2 3.7173 5.4215 2.5807 3.6607
SU-DHL-1 GDSC1; GDSC2 3.7576 6.0175 2.3178 5.197
Karpas-422 GDSC1; GDSC2 3.77 5.4143 2.6215 3.2889
PL-21 GDSC1; GDSC2 3.7808 7.6717 1.5166 10.1137
Mono-Mac-6 GDSC1 3.8259 7.9285 -0.1715 5.4266
MOLP-8 GDSC1; GDSC2 3.836 5.6936 2.5324 3.6868
Farage GDSC1; GDSC2 3.8865 5.9341 2.4512 4.0713
OCI-AML-5 GDSC1; GDSC2 3.9079 7.1209 1.886 7.5123
KE-37 GDSC1; GDSC2 3.9148 6.3628 2.2628 5.1644
OCI-AML-3 GDSC1; GDSC2 3.9654 5.3753 2.7691 2.0123
LC4-1 GDSC1; GDSC2 4.002 5.4725 3.4623 5.8619
OCI-Ly7 GDSC2 4.0031 6.3469 2.3326 4.5379
P32/ISH GDSC1; GDSC2 4.0356 5.3204 2.8362 1.5171
CML-T1 GDSC2 4.0356 6.8609 2.1061 5.851
JVM-3 GDSC1; GDSC2 4.0382 9.3281 0.8929 13.1337
OCI-AML-2 GDSC1; GDSC2 4.1117 6.1541 2.4975 3.3202
BC-1 GDSC1; GDSC2 4.1126 5.9941 2.5733 2.8738
697 GDSC1; GDSC2 4.1201 5.8705 2.6355 2.5001
TALL-1 [Human adult T-ALL] GDSC2 4.1207 8.2077 1.5086 9.3004
SR GDSC1; GDSC2 4.1728 6.4868 2.38 3.8954
BV-173 GDSC1; GDSC2 4.1787 5.9476 2.6358 2.3944
SUP-HD1 GDSC1; GDSC2 4.181 6.4315 2.4115 3.692
L-428 GDSC1; GDSC2 4.1912 6.5255 2.3738 3.8956
KMS-12-BM GDSC1; GDSC2 4.2395 6.405 2.4615 3.2858
SU-DHL-6 GDSC1; GDSC2 4.243 5.8444 2.7204 1.82
BC-3 GDSC1; GDSC2 4.2589 6.2828 2.5304 2.8528
HT GDSC1; GDSC2 4.2639 7.6142 1.9011 6.5858
MHH-PREB-1 GDSC1; GDSC2 4.3212 6.4954 2.4705 3.0837
SUP-B8 GDSC2 4.3457 9.5007 1.0386 11.5221
ST486 GDSC1; GDSC2 4.3467 6.4319 2.5153 2.7845
A3/Kawakami GDSC1; GDSC2 4.3893 5.3927 2.9839 0.4224
ALL-PO GDSC1; GDSC2 4.4306 16.5273 -2.3811 26.0727
ME1 GDSC1; GDSC2 4.4408 6.1359 2.7017 1.6307
DoHH2 GDSC1; GDSC2 4.4417 6.0092 2.7568 1.3536
MOLT-4 GDSC1; GDSC2 4.4484 7.112 3.0308 7.1008
MY-M12 GDSC1; GDSC2 4.5025 11.6188 0.8228 18.731
ML-2 GDSC1; GDSC2 4.5118 13.2828 -0.705 19.8608
NOMO-1 GDSC1; GDSC2 4.5175 7.815 2.7356 8.6162
Karpas-620 GDSC1; GDSC2 4.5383 6.0457 2.7905 1.0797
SIG-M5 GDSC1; GDSC2 4.6221 5.6657 2.9776 0.299
L-540 GDSC1; GDSC2 4.633 8.5055 1.7246 6.847
Loucy GDSC1; GDSC2 4.6331 6.1736 2.7839 1.0081
DB GDSC1; GDSC2 4.6349 7.4969 2.2007 4.0641
EM-2 GDSC1; GDSC2 4.6407 7.2474 2.319 3.385
NK-92MI GDSC2 4.6536 8.516 1.7333 6.7532
RPMI-8226 GDSC1; GDSC2 4.7015 6.4992 2.6824 1.395
JSC-1 GDSC1; GDSC2 4.722 13.5502 -0.6775 19.2159
Jiyoye GDSC1; GDSC2 4.7377 7.0871 2.4472 2.5309
Kasumi-1 GDSC2 4.7966 12.6432 -0.1741 16.7725
Reh GDSC1; GDSC2 4.7975 11.7855 0.9787 17.2328
H9 GDSC1; GDSC2 4.8078 6.7617 2.6256 1.5376
Namalwa GDSC2 4.8111 15.7622 -1.705 22.9653
GA-10 GDSC1; GDSC2 4.8307 6.3212 2.816 0.6989
Karpas-45 GDSC1; GDSC2 4.8332 6.818 2.6148 1.5592
VAL GDSC1; GDSC2 4.8429 7.1237 2.4889 2.1648
TUR GDSC1; GDSC2 4.8478 6.1998 2.8701 0.4968
BL-41 GDSC1; GDSC2 4.8503 6.3361 2.8188 0.6733
SKM-1 GDSC1; GDSC2 4.8525 6.2738 2.8439 0.5823
L-363 GDSC1; GDSC2 4.8576 13.5917 -0.5961 18.5323
LAMA-84 GDSC1; GDSC2 4.8678 7.2522 2.4465 2.3475
SU-DHL-10 GDSC1; GDSC2 4.882 5.813 3.0229 0.1057
HL-60 GDSC1; GDSC2 4.8872 7.8399 3.0089 6.1842
SU-DHL-4 GDSC1; GDSC2 4.9187 7.1838 2.5033 1.9928
OCI-M1 GDSC1; GDSC2 4.9512 6.3086 2.872 0.4283
HAL-01 GDSC1; GDSC2 4.9601 7.036 2.5871 1.5417
THP-1 GDSC1; GDSC2 4.986 11.672 0.4393 13.2819
AMO1 GDSC1; GDSC2 4.9992 6.1423 2.9511 0.2037
RPMI-6666 GDSC1; GDSC2 5.0126 6.8656 2.6824 1.0692
Karpas-231 GDSC1; GDSC2 5.0177 6.2821 2.9081 0.2955
RPMI-8866 GDSC1; GDSC2 5.0229 9.6441 2.22 10.2897
SU-DHL-5 GDSC1; GDSC2 5.0516 6.1605 2.964 0.1618
OPM-2 GDSC1; GDSC2 5.0685 6.5475 2.8307 0.4864
MV4-11 GDSC1; GDSC2 5.0705 11.6431 1.2649 15.1709
PF-382 GDSC1; GDSC2 5.0763 7.079 3.51 3.0144
SU-DHL-8 GDSC1; GDSC2 5.0967 6.4999 2.8597 0.3861
NALM-6 GDSC1; GDSC2 5.1034 6.9539 2.6888 0.9624
KOPN-8 GDSC1; GDSC2 5.1043 7.2293 2.5779 1.4264
CCRF-CEM GDSC1; GDSC2 5.1199 9.723 2.2541 9.8797
KMOE-2 GDSC1; GDSC2 5.139 13.0564 -0.1266 15.7343
MOLM-16 GDSC2 5.1471 8.0035 2.2703 2.8636
A4/Fukuda GDSC2 5.1571 6.9633 2.7092 0.8406
ROS-50 GDSC1; GDSC2 5.159 8.2486 2.1687 3.378
P30/OHK GDSC1; GDSC2 5.1784 7.3694 3.4392 3.212
SUP-B15 GDSC1; GDSC2 5.1948 13.9761 -0.5363 17.4696
TK [Human B-cell lymphoma] GDSC1; GDSC2 5.1982 6.6731 2.8364 0.3995
LP-1 GDSC1; GDSC2 5.2364 7.0757 2.7002 0.8126
Karpas-1106P GDSC2 5.2657 7.5466 2.5255 1.4895
ATN-1 GDSC1; GDSC2 5.2786 6.6626 2.8714 0.2768
Ramos.2G6.4C10 GDSC1; GDSC2 5.3016 6.6301 2.8915 0.2254
HDLM-2 GDSC1; GDSC2 5.3052 7.0946 2.7225 0.686
Hs 445 GDSC1; GDSC2 5.3209 6.6922 2.8768 0.2495
CA46 GDSC1; GDSC2 5.321 7.1537 2.7066 0.7292
MM1.S GDSC2 5.3226 6.8278 2.8289 0.361
MLMA GDSC1; GDSC2 5.3265 7.891 3.2891 3.7533
Daudi GDSC1; GDSC2 5.3343 6.7909 2.8467 0.3121
EoL-1 GDSC1; GDSC2 5.3384 12.5366 0.2676 13.3646
MEG-01 GDSC1; GDSC2 5.3391 8.1648 3.1677 4.3847
JURL-MK1 GDSC1; GDSC2 5.3435 7.0865 3.6696 1.7627
EB2 GDSC1; GDSC2 5.3503 7.1211 2.7314 0.6277
Raji GDSC1; GDSC2 5.3718 6.6164 2.9218 0.1504
IM-9 GDSC1; GDSC2 5.3745 6.5999 2.9283 0.1394
HEL GDSC1; GDSC2 5.3872 6.6962 2.8998 0.1838
RC-K8 GDSC1; GDSC2 5.4543 6.8769 2.8613 0.2368
SK-MM-2 GDSC1; GDSC2 5.4663 6.9309 2.8467 0.2628
NU-DUL-1 GDSC1; GDSC2 5.4936 6.7528 2.9183 0.1285
NCI-H929 GDSC2 5.5588 7.1963 2.7871 0.3628
BALL-1 GDSC1; GDSC2 5.5794 8.5553 3.139 4.1117
ALL-SIL GDSC1; GDSC2 5.593 7.1756 2.8075 0.3024
KM-H2 GDSC1; GDSC2 5.5932 7.5047 2.6875 0.6189
DG-75 GDSC1; GDSC2 5.6096 14.0794 -0.2901 15.434
HC-1 GDSC1; GDSC2 5.6145 7.308 2.7683 0.3852
Granta-519 GDSC1; GDSC2 5.6232 7.3037 2.7731 0.3697
DND-41 GDSC1; GDSC2 5.643 11.6611 0.8917 9.4936
RS4;11 GDSC1; GDSC2 5.6496 7.6147 2.6695 0.6413
MN-60 GDSC1; GDSC2 5.6774 7.4253 2.7502 0.4029
SUP-T1 GDSC1; GDSC2 5.6922 7.4377 3.7035 1.1881
EJM GDSC1; GDSC2 5.7059 7.1384 2.8617 0.1668
OCI-Ly19 GDSC1; GDSC2 5.74 7.3738 2.7923 0.2833
CESS GDSC1; GDSC2 5.751 10.997 2.0873 9.4164
L-1236 GDSC1; GDSC2 5.7699 18.7795 -2.4737 23.2749
KMS-11 GDSC1; GDSC2 5.7724 7.9208 2.6051 0.7694
GDM-1 GDSC1; GDSC2 5.7768 9.9252 1.7721 4.5386
JeKo-1 GDSC2 5.7954 7.2876 2.8424 0.1762
MHH-CALL-2 GDSC2 5.8056 7.3326 2.8305 0.1929
RPMI-8402 GDSC1 5.8082 9.6935 2.7508 7.8254
HH [Human lymphoma] GDSC1; GDSC2 5.8157 7.6358 2.7276 0.3998
KCL-22 GDSC1; GDSC2 5.8356 7.4935 2.7855 0.2659
CRO-AP2 GDSC2 5.8633 7.5597 2.7726 0.2829
U-698-M GDSC1; GDSC2 5.8678 9.7876 2.745 5.695
WIL2 NS GDSC1; GDSC2 5.8709 7.6446 2.7454 0.3373
KG-1 GDSC1; GDSC2 5.8761 12.7055 0.5499 10.8146
Jurkat GDSC1; GDSC2 5.8829 7.2361 2.8903 0.0959
BONNA-12 GDSC2 5.8894 8.5901 2.3961 1.4395
JVM-2 GDSC1; GDSC2 5.9119 9.37 2.0861 2.7801
WSU-NHL GDSC1; GDSC2 5.9273 7.6161 2.7763 0.2557
ARH-77 GDSC1; GDSC2 5.9285 7.6712 2.7575 0.2922
CTB-1 GDSC1; GDSC2 5.9402 8.4015 2.4926 1.0363
DEL GDSC1; GDSC2 5.9618 14.1911 -0.1011 13.8158
U266B1 GDSC1; GDSC2 5.9889 7.942 3.6401 1.1563
KY821 GDSC1; GDSC2 6.0137 15.0159 0.311 17.3119
RCH-ACV GDSC1; GDSC2 6.104 14.441 -0.1248 13.6351
JJN-3 GDSC1; GDSC2 6.1756 7.8115 2.7979 0.16
K-562 GDSC1; GDSC2 6.2804 9.2091 3.2529 2.5166
P12-Ichikawa GDSC1; GDSC2 6.3907 13.944 1.1068 12.9966
QIMR-WIL GDSC1; GDSC2 6.404 8.5929 3.5716 1.0595
Ku812 GDSC1; GDSC2 6.4975 8.0193 3.827 0.2674
GR-ST GDSC1; GDSC2 6.5741 8.8241 2.5909 0.4204
MOLT-13 GDSC1; GDSC2 6.6754 18.1353 -1.5105 18.1898
BE-13 GDSC1; GDSC2 6.9105 16.6987 -0.6642 14.4286
NKM-1 GDSC1 7.9158 17.1439 0.6015 15.3729
P31/FUJ GDSC1 8.3628 17.8556 0.5532 14.6508
⏷ Show the Full List of 167 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1; GDSC2 -3.5391 -0.4376 -3.5608 67.4659
FLO-1 GDSC1; GDSC2 2.8079 10.4485 -0.0794 27.6042
ESO-51 GDSC2 4.1614 7.4711 1.8985 6.8334
ESO-26 GDSC1; GDSC2 5.5007 15.0223 -0.8268 18.0082
KYSE-50 GDSC1; GDSC2 5.67 9.5868 2.7105 6.2407
OACP4 C GDSC1; GDSC2 5.7697 12.153 1.5376 12.2104
KYSE-220 GDSC1; GDSC2 6.1757 9.0714 3.2562 2.6326
TE-12 GDSC1; GDSC2 6.274 10.3314 2.7462 5.0067
OACM5.1 C GDSC1; GDSC2 7.1875 9.946 3.3893 1.1121
SK-GT-4 GDSC1; GDSC2 7.3874 9.9909 3.4569 0.7837
KYAE-1 GDSC1; GDSC2 9.3043 18.8437 0.6731 9.9218
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 4.5063 7.9274 1.9158 5.9786
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-FI GDSC1 3.7173 4.9764 0.9543 0.1154
NB1 GDSC1 3.913 5.0739 0.9879 0.052
Kelly GDSC1; GDSC2 4.1562 5.8066 2.6868 2.1456
SK-N-SH GDSC1 4.2084 6.0481 0.762 0.3413
SK-N-DZ GDSC1; GDSC2 4.2142 5.7112 2.7634 1.6335
NB(TU)1 GDSC1; GDSC2 4.6196 6.7204 2.5434 2.1973
CHP-212 GDSC1; GDSC2 4.9066 13.2908 -0.4113 17.5967
SJNB-12 GDSC1 4.9368 16.803 -3.6252 20.5782
NH-12 GDSC1; GDSC2 4.9553 9.2238 2.3767 9.5816
CHP-126 GDSC2 5.0519 6.7617 2.7416 0.8026
MHH-NB-11 GDSC2 5.0687 7.6774 2.3699 2.4624
SJNB-7 GDSC1; GDSC2 5.0982 7.1062 2.6253 1.227
CHP-134 GDSC1; GDSC2 5.2442 6.5435 2.9007 0.2255
IMR-5 GDSC1; GDSC2 5.2553 7.727 2.4456 1.8612
NB69 GDSC1; GDSC2 5.3195 11.6624 0.6761 11.3006
SK-N-MC-IXC GDSC1; GDSC2 5.3774 6.7303 2.8843 0.2155
SJNB-6 GDSC1; GDSC2 5.3893 7.1572 2.734 0.5958
SK-N-BE(2)-M17 GDSC1; GDSC2 5.4224 7.0341 2.7928 0.4085
SJNB-5 GDSC1; GDSC2 5.4496 15.1646 -0.9334 18.5604
SJNB-14 GDSC1; GDSC2 5.4651 7.0873 2.7902 0.3957
SJNB-10 GDSC1; GDSC2 5.4849 7.3518 2.7003 0.6437
SJNB-13 GDSC1; GDSC2 5.6377 7.3084 2.777 0.3545
KP-N-RT-BM-1 GDSC2 5.7259 8.1192 2.5086 1.1409
KP-N-YS GDSC1; GDSC2 5.7405 15.6986 -0.9849 18.1216
SiMa GDSC1; GDSC2 5.8072 7.6376 2.7237 0.4127
KP-N-YN GDSC1; GDSC2 5.946 15.4375 -0.7128 16.5597
LA-N-6 GDSC1; GDSC2 6.0396 8.2079 2.607 0.6112
TGW GDSC1; GDSC2 6.1583 7.9061 2.7594 0.2226
GI-ME-N GDSC1; GDSC2 6.1765 8.4672 2.5661 0.6557
GOTO GDSC1; GDSC2 6.3187 13.789 1.1315 13.0276
SJNB-17 GDSC1; GDSC2 6.7865 13.2887 1.6885 9.4562
SK-N-AS GDSC1; GDSC2 7.4145 19.2945 -1.565 16.9823
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 4.5619 8.965 1.455 8.5893
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUB-M GDSC1; GDSC2 -1.6635 2.3706 -1.7993 54.1409
MDA-MB-231 GDSC1; GDSC2 -0.3626 12.3617 -4.0511 46.7954
Evsa-T GDSC1; GDSC2 2.4774 8.5274 0.5367 26.3011
EFM-19 GDSC1; GDSC2 3.3548 15.0951 -1.8904 31.4086
BT-483 GDSC1 3.5577 5.6224 0.6607 1.0772
HCC202 GDSC1 3.696 7.4146 -0.017 4.6893
UACC-812 GDSC1 4.0601 5.7288 0.819 0.2661
MRK-nu-1 GDSC1; GDSC2 4.2959 9.6794 1.6215 15.3516
HCC1419 GDSC1; GDSC2 4.763 6.5684 3.5417 3.4494
DU4475 GDSC1; GDSC2 5.089 9.551 2.3159 9.6104
HDQ-P1 GDSC1; GDSC2 5.1297 14.2651 0.0064 20.6073
COLO 824 GDSC1; GDSC2 5.279 9.7931 2.3372 9.0704
MDA-MB-330 GDSC1; GDSC2 5.3785 13.5422 0.56 17.7033
T-47D GDSC1; GDSC2 5.4458 8.9044 2.0389 3.6359
BT-474 GDSC1; GDSC2 5.4641 11.7772 1.4981 13.0842
HCC1500 GDSC1; GDSC2 5.5917 7.1245 2.825 0.2654
JIMT-1 GDSC2 5.599 7.2238 2.7925 0.3337
HCC1395 GDSC1 5.6074 9.3764 2.7691 8.2037
MDA-MB-157 GDSC1; GDSC2 5.6494 15.7769 -1.0885 18.7343
ZR-75-30 GDSC1; GDSC2 5.6509 8.8136 3.0634 4.3883
HCC38 GDSC1; GDSC2 5.6525 7.6546 2.6557 0.6823
HCC2218 GDSC1; GDSC2 5.6869 11.6703 1.7139 11.4948
MDA-MB-453 GDSC1; GDSC2 5.7612 15.0045 0.1276 18.6288
HCC1569 GDSC1; GDSC2 5.9221 8.5674 3.3378 2.5782
MDA-MB-175-VII GDSC1 6.1295 8.1041 3.6408 1.4103
HCC1954 GDSC1; GDSC2 6.1597 7.8244 3.764 0.5853
HCC1937 GDSC1; GDSC2 6.1664 13.1099 1.3541 12.2798
HCC70 GDSC1; GDSC2 6.2887 13.4515 1.2742 12.4139
HCC1599 GDSC1; GDSC2 6.3324 14.9101 0.5955 15.4184
EFM-192A GDSC1; GDSC2 6.3763 10.0698 2.9257 3.952
Hs 578T GDSC1; GDSC2 6.387 8.7534 3.499 1.3469
HCC2157 GDSC1; GDSC2 6.4052 8.0469 3.7814 0.4068
MDA-MB-361 GDSC1; GDSC2 6.4242 8.1493 3.7512 0.4759
CAL-148 GDSC1 6.4865 7.8375 3.8867 0.2241
MCF-7 GDSC1; GDSC2 6.5393 8.3729 3.7148 0.5159
CAL-120 GDSC1; GDSC2 6.5489 7.9143 3.8826 0.1553
HCC1143 GDSC2 6.6128 12.235 1.2171 6.1216
HCC1428 GDSC1; GDSC2 6.6231 8.0396 3.8661 0.1633
CAL-51 GDSC1; GDSC2 6.6552 8.3371 3.7734 0.3236
MDA-MB-436 GDSC1; GDSC2 6.6774 9.7857 3.2136 2.2341
AU565 GDSC1; GDSC2 6.7949 10.5676 2.9396 3.3226
MFM-223 GDSC1; GDSC2 6.8279 8.7195 3.7021 0.4161
BT-20 GDSC1; GDSC2 6.8893 8.4003 3.8371 0.1482
BT-549 GDSC1; GDSC2 6.9096 9.2707 3.5298 0.8444
HCC1806 GDSC1; GDSC2 6.9894 14.2649 1.3591 10.6662
UACC-893 GDSC1; GDSC2 7.011 19.2267 -1.8056 18.5847
CAL-85-1 GDSC1; GDSC2 7.3926 19.7507 -1.7976 17.8423
HCC1187 GDSC1; GDSC2 7.7384 18.559 -0.1899 15.8429
MDA-MB-468 GDSC1; GDSC2 8.4482 19.803 -0.3089 15.0373
MDA-MB-415 GDSC1; GDSC2 8.5246 18.7499 0.2375 12.8413
YMB-1-E GDSC1; GDSC2 8.606 16.0614 1.5211 7.3658
CAMA-1 GDSC1; GDSC2 9.7634 21.0257 -0.0486 12.0201
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
M059J GDSC1; GDSC2 0.4854 11.1786 -3.1637 39.9725
D-566MG GDSC1; GDSC2 3.4215 13.216 -1.5424 26.0593
MOG-G-UVW GDSC1 3.5809 5.438 0.7404 0.7336
MOG-G-CCM GDSC1 3.6664 6.4048 0.3983 2.2635
YKG-1 GDSC1; GDSC2 3.7157 13.4911 -1.4383 24.861
SW1783 GDSC1 3.7637 6.7091 0.3201 2.5656
U-87MG ATCC GDSC1; GDSC2 3.7971 5.7727 2.4664 4.1808
LNZTA3WT4 GDSC1 3.8419 5.1244 0.9474 0.1024
8-MG-BA GDSC1; GDSC2 4.227 19.1811 -3.8666 30.3563
D-542MG GDSC1; GDSC2 4.2278 6.3337 2.4874 3.1575
LN-229 GDSC1; GDSC2 4.2719 6.3042 2.5285 2.8403
A-172 GDSC1; GDSC2 4.2888 6.7377 2.3369 3.9211
YH-13 GDSC1; GDSC2 4.2993 6.462 2.4724 3.1127
SF539 GDSC1; GDSC2 4.3061 9.782 0.8709 12.5735
D-263MG GDSC1; GDSC2 4.4079 7.1482 2.2205 4.3743
GB-1 GDSC1; GDSC2 4.5366 6.2259 2.7136 1.4451
D-247MG GDSC1; GDSC2 4.5682 10.3106 0.8039 12.3064
AM-38 GDSC1; GDSC2 4.5875 8.7547 1.5742 7.8309
SF295 GDSC1; GDSC2 4.6268 13.7109 -0.8292 20.0921
D283 Med GDSC1; GDSC2 4.9093 6.6977 2.7018 1.0862
LN-18 GDSC1; GDSC2 4.9226 6.1614 2.9149 0.3215
Onda 10 GDSC1; GDSC2 4.9429 16.4781 -1.9589 23.5081
NMC-G1 GDSC1; GDSC2 4.954 6.4279 2.8282 0.5663
SF268 GDSC1; GDSC2 4.9788 7.2228 2.5179 1.8464
T98G GDSC1; GDSC2 4.9876 6.7729 2.708 0.9873
Hs 683 GDSC1; GDSC2 5.1116 6.5229 2.8572 0.3856
CAS-1 GDSC1; GDSC2 5.2499 15.9027 -1.4429 20.9893
ONS-76 GDSC1; GDSC2 5.2589 7.5911 2.5039 1.5918
Becker GDSC1; GDSC2 5.2783 11.1966 0.8715 10.3421
DK-MG GDSC1; GDSC2 5.2918 7.168 2.6886 0.8133
LN-405 GDSC1; GDSC2 5.3353 7.0198 2.7633 0.5374
H4 GDSC1; GDSC2 5.5182 7.4024 2.6951 0.6399
GaMG GDSC1; GDSC2 5.5445 7.3914 2.71 0.579
GI-1 GDSC1; GDSC2 5.5615 7.1497 2.8048 0.3201
D-502MG GDSC1; GDSC2 5.6109 7.67 2.6325 0.784
U-118MG GDSC1; GDSC2 5.6119 8.9442 2.1118 3.0329
U-251MG GDSC1; GDSC2 5.6159 7.5973 2.6621 0.6843
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 5.6283 8.0259 2.5016 1.2486
SW1088 GDSC1; GDSC2 5.6637 7.6845 2.6491 0.6964
SNB-75 GDSC1; GDSC2 5.7353 8.1652 2.4947 1.1857
D-336MG GDSC1; GDSC2 5.7549 8.4453 2.392 1.5781
42-MG-BA GDSC1; GDSC2 5.8127 10.3347 1.6095 5.3396
Onda 11 GDSC1; GDSC2 5.834 8.1444 2.5459 0.9258
D-423MG GDSC1; GDSC2 5.8442 14.1392 -0.1564 14.3174
D-392MG GDSC1; GDSC2 6.1194 8.6965 2.4561 1.0366
KALS-1 GDSC1; GDSC2 6.4451 25.8874 -5.4755 29.0275
D-245MG GDSC2 6.4457 12.0306 1.213 6.3989
KINGS-1 GDSC1; GDSC2 7.2677 16.6592 -0.4152 12.7233
SK-MG-1 GDSC1; GDSC2 7.4317 25.1038 -4.3628 24.9967
KNS-81-FD GDSC1; GDSC2 7.8272 18.2862 -0.8218 13.4325
SF126 GDSC1; GDSC2 8.6802 21.5703 -1.8169 15.688
PFSK-1 GDSC1; GDSC2 9.2284 27.197 -4.1243 21.4746
KNS-42 GDSC1; GDSC2 9.5255 22.5582 -1.7495 14.1478
DBTRG-05MG GDSC1; GDSC2 9.9805 21.2772 -0.9016 10.4932
Daoy GDSC1; GDSC2 11.2996 26.987 -2.7085 14.6959
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 -0.3059 1.7735 -0.5867 22.646
TGBC24TKB GDSC1; GDSC2 5.2927 7.5752 2.5268 1.4567
ETK-1 GDSC1; GDSC2 6.9385 14.8048 1.0681 12.1061
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC1; GDSC2 -2.8378 0.9008 -2.9266 60.5278
AN3-CA GDSC1; GDSC2 4.5925 13.3337 -0.6686 19.5012
MFE-280 GDSC1; GDSC2 5.3618 8.372 2.2259 2.7943
EN GDSC1; GDSC2 5.5085 6.7972 2.9084 0.1398
RL95-2 GDSC1; GDSC2 5.894 7.457 3.7909 0.6753
MFE-296 GDSC1; GDSC2 5.9184 9.3534 2.0964 2.7234
KLE GDSC1; GDSC2 6.7419 15.7727 0.4665 15.1313
MFE-319 GDSC1; GDSC2 9.9099 24.2487 -2.2937 15.3592
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-140 GDSC1; GDSC2 3.8524 9.8488 0.4893 15.8703
SW13 GDSC1; GDSC2 4.333 6.5501 2.4525 3.1661
SW156 GDSC1; GDSC2 4.4021 6.8406 2.3606 3.5687
OS-RC-2 GDSC1; GDSC2 4.6472 10.4422 0.7967 12.1582
A-498 GDSC1; GDSC2 4.6764 13.0452 -0.4623 18.3887
769-P GDSC1; GDSC2 4.7719 6.5549 2.6942 1.261
BFTC-909 GDSC1; GDSC2 4.8074 6.8413 2.5917 1.7009
RCC10RGB GDSC1; GDSC2 4.9911 6.6061 2.7755 0.7244
KTCTL-13 GDSC1; GDSC2 5.0324 8.0574 2.182 3.5008
VMRC-RCZ GDSC1; GDSC2 5.3129 6.9218 2.7907 0.4691
CAL-54 GDSC1; GDSC2 5.5209 7.5781 2.6293 0.8569
NCC021 GDSC1; GDSC2 5.6746 7.6183 2.6783 0.6004
HA7-RCC GDSC1; GDSC2 5.7798 7.8041 2.6519 0.6202
KTCTL-1M GDSC1; GDSC2 5.8033 8.1735 2.5215 1.0338
ACHN GDSC1; GDSC2 5.868 8.0577 2.5932 0.7484
SN12C GDSC1; GDSC2 5.9126 7.9569 2.6487 0.5595
NCC010 GDSC2 5.9243 19.4079 -2.6687 23.5297
786-O GDSC1; GDSC2 6.0245 7.7159 2.7769 0.2274
UO-31 GDSC1; GDSC2 6.1235 8.124 2.6701 0.4117
LB1047-RCC GDSC1; GDSC2 6.1251 8.1114 2.6752 0.3994
VMRC-RCW GDSC1; GDSC2 6.1376 15.2165 -0.4739 15.1347
LB996-RCC GDSC1; GDSC2 6.1637 8.7561 2.4522 1.0194
KTCTL-21 GDSC1; GDSC2 6.3094 8.8232 2.4877 0.8134
Caki-1 GDSC1; GDSC2 6.3542 11.2451 1.5108 5.0276
A-704 GDSC1; GDSC2 6.5684 17.3291 -1.1955 17.2229
KTCTL-26A GDSC1; GDSC2 6.5723 8.3143 2.7659 0.1308
TK-10 GDSC1; GDSC2 6.8304 8.908 2.655 0.2293
LB2241-RCC GDSC1; GDSC2 6.9008 15.131 0.0667 11.2345
RXF 393L GDSC1; GDSC2 7.3587 18.7939 -1.3637 16.3493
KTCTL-195 GDSC1; GDSC2 7.4267 20.7094 -2.2344 19.237
KMRC-1 GDSC1 7.8461 22.1041 -4.2373 17.1462
BB65-RCC GDSC1; GDSC2 7.8524 21.2933 -2.2263 18.4458
KMRC-20 GDSC1; GDSC2 9.8025 26.8814 -3.5938 19.2622
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-C2B GDSC1; GDSC2 0.5391 11.0015 -3.0273 39.5425
SNU-C1 GDSC1; GDSC2 4.1888 18.4072 -3.511 29.6458
SNU-C5 GDSC1; GDSC2 4.292 10.2185 0.645 13.8627
NCI-H508 GDSC2 4.4335 9.2525 1.2242 10.2372
HCT 15 GDSC1; GDSC2 4.5201 6.7228 2.4858 2.6595
LS180 GDSC1; GDSC2 4.5639 6.4087 2.6494 1.729
SW948 GDSC1; GDSC2 4.632 6.0722 2.8246 0.8359
HT115 GDSC1; GDSC2 4.6408 6.1314 2.8048 0.9103
SNU-81 GDSC1; GDSC2 4.68 8.1174 1.9395 5.4907
HT-29 GDSC1; GDSC2 4.6957 6.1762 2.8124 0.8276
LoVo GDSC1; GDSC2 4.8479 10.1134 1.0985 10.0125
COLO205 GDSC1; GDSC2 4.8485 6.3525 2.8117 0.7012
SW48 GDSC1; GDSC2 4.8525 6.9687 2.5607 1.7949
SNU-407 GDSC1; GDSC2 4.8553 10.1214 1.0997 9.9889
LS411N GDSC1; GDSC2 4.9302 6.2019 2.903 0.35
SNU-175 GDSC1; GDSC2 4.9882 6.7985 2.698 1.0276
LS123 GDSC1; GDSC2 5.01 11.7683 0.4095 13.3815
HT-55 GDSC1; GDSC2 5.0189 11.1913 0.696 11.8513
SNU-1040 GDSC1; GDSC2 5.0687 6.3604 2.8996 0.2947
SW837 GDSC1; GDSC2 5.0961 7.2286 2.5742 1.4514
SNU-283 GDSC2 5.1711 6.7833 2.7844 0.5696
RKO GDSC1; GDSC2 5.2283 9.9197 1.4442 7.2716
SW1116 GDSC1; GDSC2 5.2661 7.0299 2.7307 0.6849
RCM-1 [Human ESC] GDSC1; GDSC2 5.2723 7.0339 2.7317 0.6771
LS1034 GDSC1; GDSC2 5.3117 6.938 2.7841 0.4886
LS513 GDSC1; GDSC2 5.3192 7.0217 2.756 0.5692
CaR-1 GDSC1; GDSC2 5.3209 12.1711 0.4322 12.5688
C2BBe1 GDSC2 5.3683 7.5851 2.5583 1.2515
COLO 320HSR GDSC1; GDSC2 5.4162 8.0669 2.3839 1.9642
CL-11 GDSC1; GDSC2 5.4394 7.3172 2.6944 0.6913
NCI-H747 GDSC1; GDSC2 5.4745 14.2232 -0.4556 16.4759
MDST8 GDSC1; GDSC2 5.5496 6.7239 2.9473 0.0824
SW1463 GDSC1; GDSC2 5.5723 7.7996 2.5657 1.0488
KM12 GDSC1; GDSC2 5.6639 7.5501 2.6993 0.5452
SW626 GDSC1; GDSC2 5.7603 8.0526 2.5496 0.9651
CCK-81 GDSC1; GDSC2 5.767 7.7907 2.6517 0.628
NCI-H716 GDSC1; GDSC2 5.7699 7.6957 2.688 0.5228
HCT 116 GDSC1; GDSC2 5.8317 7.2145 2.8799 0.116
SNU-61 GDSC1; GDSC2 5.9159 7.7871 2.7116 0.3969
CW-2 GDSC1; GDSC2 5.9977 7.5478 2.825 0.1578
HCC2998 GDSC1; GDSC2 6.0005 14.1085 -0.0354 13.4297
COLO 678 GDSC1; GDSC2 6.0214 8.6297 2.4396 1.1663
DiFi GDSC2 6.1221 8.6704 2.4673 0.9967
SK-CO-1 GDSC2 6.3027 8.2462 2.6937 0.3002
T84 GDSC1; GDSC2 6.3615 8.2659 2.7083 0.257
SW1417 GDSC1; GDSC2 6.5477 15.8467 -0.4991 14.4232
GP5d GDSC1; GDSC2 6.6947 16.3048 -0.6196 14.6518
SW620 GDSC1; GDSC2 9.3962 21.1463 -1.1812 12.3357
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 5.726 7.2135 2.843 0.1922
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-475 GDSC1 2.8515 5.6997 0.2677 4.4328
HuH-1 GDSC1; GDSC2 3.8876 5.5985 2.6136 3.0822
JHH-2 GDSC1; GDSC2 4.3616 6.6818 2.4091 3.3631
JHH-6 GDSC1; GDSC2 4.3954 9.5725 1.0399 11.3932
Hep-G2/C3A GDSC1; GDSC2 5.2272 6.4841 2.9153 0.2017
JHH-1 GDSC1; GDSC2 5.4589 16.9908 -1.8236 21.8633
SNU-398 GDSC1; GDSC2 5.5116 7.3406 2.7155 0.5811
HLE GDSC1; GDSC2 5.6686 7.823 2.5985 0.8599
Huh-7 GDSC1; GDSC2 5.8351 7.8094 3.6194 1.3953
SK-HEP-1 GDSC1; GDSC2 5.9249 7.2899 2.8866 0.0937
SNU-387 GDSC1; GDSC2 6.7466 15.8567 -0.3727 13.4927
Hep 3B2.1-7 GDSC1; GDSC2 6.9234 17.5061 -1.0398 15.9253
SNU-423 GDSC1; GDSC2 8.0606 20.4356 -1.6814 16.2512
JHH-7 GDSC1; GDSC2 9.0422 18.9732 -0.4073 9.8803
JHH-4 GDSC1; GDSC2 10.1986 22.7085 -1.4174 12.0471
SNU-449 GDSC1; GDSC2 10.2994 21.4939 -0.8192 9.7748
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 183 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H64 GDSC1 -0.8176 5.8235 -2.8735 37.0336
NCI-H1781 GDSC1; GDSC2 2.1358 12.8022 -2.4397 32.6851
RERF-LC-KJ GDSC1; GDSC2 2.2055 5.7436 1.0894 17.6874
HCC366 GDSC2 2.7629 9.5509 -0.2699 22.9789
COR-L88 GDSC1 2.8536 5.0177 0.5712 2.4337
NCI-H847 GDSC1 2.8768 4.5671 0.7714 1.2476
NCI-H2066 GDSC1 3.0176 7.2011 -0.3249 8.1613
NCI-H1568 GDSC1; GDSC2 3.2043 6.5471 1.6103 11.1591
NCI-H1734 GDSC1; GDSC2 3.3924 5.4131 2.3345 6.0492
EPLC-272H GDSC1; GDSC2 3.4006 13.4287 -1.666 26.5417
NCI-H2347 GDSC1 3.4053 5.9683 0.451 2.3191
NCI-H2009 GDSC1 3.4614 5.5982 0.6278 1.3206
NCI-H1648 GDSC1 3.5045 13.5496 -3.056 21.8536
NCI-H187 GDSC1 3.6051 10.0407 -1.2852 12.8661
NCI-H1688 GDSC1 3.6553 5.4285 0.7737 0.5678
SW1271 GDSC1; GDSC2 3.7105 9.1972 0.7015 15.1011
NCI-H1573 GDSC1 3.729 5.3415 0.8331 0.3548
NCI-H1092 GDSC1; GDSC2 3.7476 5.6879 2.4722 4.2614
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 3.849 5.9548 2.4147 4.3803
NCI-H720 GDSC1; GDSC2 3.8891 6.5475 2.154 5.8978
NCI-H345 GDSC1; GDSC2 3.8994 5.8547 2.4985 3.7543
NCI-H1304 GDSC1 3.9507 15.2009 -3.5411 22.5682
Lu-165 GDSC1; GDSC2 4.069 6.2218 2.4374 3.764
Lu-65 GDSC1; GDSC2 4.0937 7.3204 1.9237 6.8351
NCI-H647 GDSC1; GDSC2 4.1621 7.377 1.9447 6.5493
RERF-LC-MS GDSC1; GDSC2 4.188 8.0646 1.6279 8.416
NCI-H23 GDSC1; GDSC2 4.2133 7.8727 1.7398 7.6786
NCI-H1755 GDSC1; GDSC2 4.251 11.1004 0.1773 16.431
BEN GDSC1; GDSC2 4.2936 11.4343 0.0443 16.9844
NCI-H2023 GDSC1; GDSC2 4.313 6.0438 2.6713 1.9769
LOU-NH91 GDSC1; GDSC2 4.3378 6.6767 2.3967 3.4789
PaCa-3 GDSC1 4.3476 7.0123 0.4651 1.2332
NCI-H2342 GDSC1 4.3579 10.2762 -0.92 8.9917
NCI-H1155 GDSC1; GDSC2 4.3791 16.1947 -2.256 25.8228
NCI-H1838 GDSC1 4.4069 7.0927 0.4595 1.2084
SBC-5 GDSC1; GDSC2 4.4224 5.6337 2.9036 0.7048
NCI-H2804 GDSC1; GDSC2 4.4358 10.7849 0.4732 14.4245
NCI-H2373 GDSC1; GDSC2 4.4976 6.3918 2.6207 1.9696
NCI-H82 GDSC1; GDSC2 4.5833 6.5122 2.6149 1.8781
NCI-H2196 GDSC1; GDSC2 4.589 7.5878 2.1298 4.5571
IST-SL2 GDSC1; GDSC2 4.5938 9.4344 1.2499 9.7157
NCI-H1993 GDSC1; GDSC2 4.5953 9.4117 1.2619 9.6425
NCI-H1694 GDSC1; GDSC2 4.6051 6.4678 2.6458 1.6924
NCI-H596 GDSC1; GDSC2 4.6341 6.9968 2.4286 2.7902
NCI-H196 GDSC1; GDSC2 4.641 6.5578 2.6261 1.7437
NCI-H1915 GDSC1; GDSC2 4.6497 12.354 -0.1409 16.9757
NCI-H513 GDSC1; GDSC2 4.655 6.5856 2.6215 1.7481
SBC-3 GDSC1; GDSC2 4.7167 6.722 2.5954 1.7976
A-549 GDSC1; GDSC2 4.7496 7.176 2.4145 2.6873
NCI-H1650 GDSC1; GDSC2 4.7526 9.4424 1.3563 8.7461
NCI-H1299 GDSC1; GDSC2 4.7674 16.4143 -2.0621 24.2633
NCI-H226 GDSC1; GDSC2 4.7753 6.406 2.7569 0.9828
NCI-H2810 GDSC1; GDSC2 4.7899 11.2013 0.5286 13.2707
NCI-H2172 GDSC1; GDSC2 4.8035 7.87 2.1319 4.1564
NCI-H2461 GDSC1; GDSC2 4.8084 6.9448 2.5479 1.9143
NCI-H2291 GDSC1; GDSC2 4.8543 7.0762 2.5156 2.0154
NCI-H2029 GDSC1; GDSC2 4.8868 6.8181 2.6415 1.374
NCI-H2171 GDSC1; GDSC2 4.8949 6.4889 2.7787 0.7884
LK-2 GDSC1; GDSC2 4.8958 6.8857 2.6179 1.4723
NCI-H2228 GDSC1; GDSC2 4.8979 10.2552 1.0646 10.0935
LXF 289 GDSC1; GDSC2 4.9192 7.0965 2.5408 1.8088
NCI-H510A GDSC1; GDSC2 4.9461 7.2829 2.4751 2.097
NCI-H2141 GDSC1; GDSC2 4.9897 6.5227 2.8071 0.6135
NCI-H2122 GDSC1; GDSC2 5.0023 6.8596 2.68 1.089
NCI-H1975 GDSC1; GDSC2 5.0134 6.8576 2.686 1.0538
NCI-H209 GDSC1; GDSC2 5.0308 7.4318 2.4557 2.0838
NCI-H2444 GDSC1; GDSC2 5.0406 6.7189 2.7532 0.7681
COR-L105 GDSC1; GDSC2 5.0589 10.6043 1.0069 10.0656
NCI-H526 GDSC1; GDSC2 5.0603 6.481 2.8522 0.4266
Lu-139 GDSC1; GDSC2 5.0964 6.8814 2.7143 0.8696
VMRC-LCD GDSC2 5.1103 15.303 -1.2513 20.598
NCI-H838 GDSC1; GDSC2 5.1224 7.0499 2.6593 1.0636
NCI-H2081 GDSC1; GDSC2 5.1817 7.4111 2.5406 1.5105
COR-L311 GDSC1; GDSC2 5.192 6.7377 2.8101 0.4781
NCI-H3122 GDSC1; GDSC2 5.1964 7.7509 2.4056 2.1208
NCI-H1836 GDSC1; GDSC2 5.2056 7.0295 2.7047 0.8196
KNS-62 GDSC1; GDSC2 5.2195 7.4475 2.5439 1.4565
LCLC-97TM1 GDSC1; GDSC2 5.237 7.456 2.5488 1.4175
PC-14 GDSC1; GDSC2 5.2398 7.496 2.5338 1.4799
NCI-H290 GDSC1; GDSC2 5.2416 10.7342 1.0677 9.3457
NCI-H727 GDSC1; GDSC2 5.262 7.3927 2.5863 1.2342
NCI-H1793 GDSC1; GDSC2 5.2725 7.2327 2.6548 0.9529
Calu-6 GDSC1; GDSC2 5.2737 6.9702 2.7565 0.5951
NCI-H1105 GDSC1; GDSC2 5.2912 11.0517 0.9494 9.8918
SHP-77 GDSC1; GDSC2 5.2962 6.5537 2.9162 0.1795
Ms-1 GDSC1; GDSC2 5.2985 7.0774 2.7262 0.6781
NCI-H650 GDSC1; GDSC2 5.309 8.3537 2.2054 2.9701
Lu-135 GDSC1; GDSC2 5.3091 7.1446 2.705 0.7429
HOP-92 GDSC2 5.3141 8.1499 2.2964 2.5061
EMC-BAC-1 GDSC1; GDSC2 5.3323 8.9111 1.9716 4.1648
NCI-H2591 GDSC1; GDSC2 5.3403 7.9897 2.3781 2.0787
CPC-N GDSC1; GDSC2 5.36 7.0008 2.7803 0.4738
NCI-H1651 GDSC1; GDSC2 5.3637 7.8831 2.4344 1.7917
SBC-1 GDSC1; GDSC2 5.3893 7.0516 2.7733 0.4783
NCI-H2369 GDSC1; GDSC2 5.3918 6.572 2.944 0.1131
NCI-H1770 GDSC1; GDSC2 5.3979 7.6211 2.5576 1.2274
IA-LM GDSC1; GDSC2 5.4091 6.7977 2.8723 0.2291
NCI-H2227 GDSC2 5.4271 11.4117 0.8683 10.0515
RERF-LC-Sq1 GDSC1; GDSC2 5.4376 13.6219 -0.1891 15.3489
DMS 79 GDSC2 5.4376 6.9135 2.8421 0.283
NCI-H2087 GDSC1; GDSC2 5.4564 7.6907 2.5566 1.1797
NCI-H810 GDSC1; GDSC2 5.4636 6.9733 2.8306 0.2988
COR-L303 GDSC1; GDSC2 5.4703 7.4368 2.6619 0.7796
NCI-H1876 GDSC1; GDSC2 5.5084 7.5957 2.6171 0.9092
NCI-H1048 GDSC1; GDSC2 5.5122 11.9906 0.649 11.0383
Calu-3 GDSC1; GDSC2 5.5645 7.976 2.4923 1.342
NCI-H524 GDSC1; GDSC2 5.5953 7.1756 2.8083 0.2996
NCI-H522 GDSC1; GDSC2 5.5997 15.507 -0.9924 18.4624
NCI-H1581 GDSC1; GDSC2 5.6006 7.1579 2.8166 0.28
NCI-H1963 GDSC2 5.6125 7.404 2.7326 0.4786
DMS 273 GDSC1; GDSC2 5.6211 7.1733 2.8187 0.2685
NCI-H2731 GDSC1; GDSC2 5.6241 11.7403 0.842 9.7952
NCI-H1435 GDSC1; GDSC2 5.6388 11.2598 1.0777 8.5054
NCI-H2135 GDSC1; GDSC2 5.6578 7.3437 2.772 0.3582
COR-L321 GDSC1; GDSC2 5.661 7.3676 2.7647 0.3744
NCI-H740 GDSC2 5.6686 8.5284 2.3167 1.9915
SK-MES-1 GDSC1; GDSC2 5.6716 14.4395 -0.4212 15.8882
LB647-SCLC GDSC1; GDSC2 5.6752 7.4547 2.7387 0.4328
NCI-H2595 GDSC1; GDSC2 5.6775 7.73 2.6377 0.724
NCI-H2818 GDSC1; GDSC2 5.7003 7.2116 2.8344 0.214
HCC33 GDSC1; GDSC2 5.7179 7.4327 2.7631 0.3554
NCI-H446 GDSC1; GDSC2 5.7238 7.732 2.656 0.6395
HCC15 GDSC1; GDSC2 5.7311 7.6617 2.685 0.5507
NCI-H441 GDSC1; GDSC2 5.7344 7.7546 2.6519 0.6458
NCI-H460 GDSC1; GDSC2 5.7466 7.0222 2.9151 0.0887
UMC-11 GDSC1; GDSC2 5.7478 7.1989 2.8558 0.1662
DMS 53 GDSC1; GDSC2 5.7538 7.3479 2.8064 0.2506
NCI-H1693 GDSC2 5.7553 18.627 -2.4094 23.1109
NCI-H2722 GDSC1; GDSC2 5.7576 7.6439 2.7021 0.4904
NCI-H250 GDSC2 5.7701 7.3144 2.8241 0.2133
LC-1/sq GDSC2 5.7877 9.2684 2.0651 3.0353
NCI-H1436 GDSC1; GDSC2 5.8141 7.4744 2.7843 0.2752
NCI-H841 GDSC1; GDSC2 5.8148 7.4333 2.799 0.2465
Lu-99A GDSC1; GDSC2 5.8196 8.0421 2.5789 0.8246
ABC-1 GDSC1; GDSC2 5.832 12.2524 0.7352 9.9481
NCI-H1792 GDSC1; GDSC2 5.8418 7.7885 2.6824 0.5028
LC-2/ad GDSC1; GDSC2 5.8952 7.5486 2.7881 0.2431
NCI-H1623 GDSC1; GDSC2 5.9005 14.7182 -0.3967 15.2882
NCI-H1437 GDSC1; GDSC2 5.903 7.9396 2.6513 0.5573
NCI-H748 GDSC2 5.9057 7.7209 2.7314 0.3556
NCI-H2795 GDSC1; GDSC2 5.9138 7.975 2.6426 0.576
NCI-H69 GDSC1 5.9328 20.8142 -4.8735 22.5371
COR-L32 GDSC2 5.9371 8.5233 2.4439 1.2155
NCI-H292 GDSC1; GDSC2 5.95 7.6875 2.7597 0.2809
HOP-62 GDSC1; GDSC2 5.963 7.8095 2.7215 0.3564
COLO 668 GDSC1; GDSC2 5.9665 8.0147 2.6489 0.5327
NCI-H322M GDSC1; GDSC2 5.9831 15.4412 -0.6887 16.3796
NCI-H2030 GDSC1; GDSC2 5.9874 7.8991 2.6988 0.3986
NCI-H1341 GDSC1 6.0026 17.1745 -3.0973 16.3537
NCI-H1944 GDSC1; GDSC2 6.0405 12.4064 0.796 9.2377
EKVX GDSC1; GDSC2 6.0637 8.594 2.4716 1.0219
NCI-H2869 GDSC1; GDSC2 6.0791 8.176 2.6343 0.5183
NCI-H2803 GDSC1; GDSC2 6.088 12.2187 0.913 8.5456
IST-SL1 GDSC1; GDSC2 6.0949 7.8448 2.7578 0.242
NCI-H146 GDSC1; GDSC2 6.1018 10.923 1.5119 5.3983
NCI-H661 GDSC1; GDSC2 6.1357 14.4825 -0.1234 13.5645
SW1573 GDSC1; GDSC2 6.1616 8.2448 2.6413 0.4644
NCI-H211 GDSC1; GDSC2 6.1624 13.1393 0.5304 10.3608
NCI-H3255 GDSC1; GDSC2 6.2172 15.9113 -0.7538 16.165
NCI-H2085 GDSC1; GDSC2 6.234 13.8317 0.2506 11.6017
DMS 114 GDSC1; GDSC2 6.2395 7.923 2.7824 0.1688
NCI-H2405 GDSC1; GDSC2 6.4422 15.6401 -0.471 14.5085
Lu-134-A GDSC1; GDSC2 6.5096 16.3829 -0.781 15.6876
NCI-H1869 GDSC1; GDSC2 6.5479 16.8556 -0.9818 16.4262
CAL-12T GDSC1; GDSC2 6.5676 14.4657 0.1669 11.3719
SK-LU-1 GDSC1; GDSC2 6.6162 14.2455 0.3007 10.647
HCC78 GDSC1; GDSC2 6.6256 14.3242 0.2698 10.7774
NCI-H2110 GDSC1; GDSC2 6.7224 16.5594 -0.7224 15.0289
NCI-H1703 GDSC1 6.7609 18.7047 -3.3344 15.8518
HCC44 GDSC1; GDSC2 6.7819 18.7489 -1.7331 18.7751
A-427 GDSC1; GDSC2 6.9817 15.373 0.0048 11.3746
EMC-BAC-2 GDSC1; GDSC2 7.5141 18.4473 -1.0974 15.0603
NCI-H358 GDSC1; GDSC2 7.6347 18.1566 -0.8831 14.0079
NCI-H1563 GDSC1; GDSC2 8.2922 19.7349 -1.2048 14.1342
HCC827 GDSC1; GDSC2 8.3268 18.979 -0.833 12.6521
NCI-H2170 GDSC1; GDSC2 8.47 17.3426 -0.0052 9.0373
COR-L23 GDSC1; GDSC2 8.5176 19.7025 -1.0498 13.1849
NCI-H1666 GDSC1; GDSC2 8.5492 20.9443 -1.6071 15.1739
EBC-1 GDSC1; GDSC2 8.6067 20.4382 -1.3354 14.1064
NCI-H520 GDSC1; GDSC2 8.8996 23.436 -2.5532 17.7117
NCI-H1355 GDSC1; GDSC2 9.1133 22.0282 -1.7582 14.8025
ChaGo-K-1 GDSC1; GDSC2 9.3279 22.8763 -2.0184 15.3439
LCLC-103H GDSC1; GDSC2 9.7325 25.8453 -3.1505 18.1651
⏷ Show the Full List of 183 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 4.0757 5.9435 2.5735 2.9429
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE21 GDSC1; GDSC2 3.8884 6.2722 2.2881 5.0699
OE33 GDSC1; GDSC2 3.9373 6.504 2.21 5.4382
TE-11 GDSC1; GDSC2 3.9823 10.7687 0.1335 17.3684
TE-9 GDSC1; GDSC2 4.3772 5.9811 2.7347 1.5495
KYSE-450 GDSC1; GDSC2 4.9188 13.1736 0.3832 19.592
TE-10 GDSC1; GDSC2 5.2446 7.7545 2.4287 1.9527
TE-6 GDSC1; GDSC2 5.3695 7.7861 2.4773 1.5939
EC-GI-10 GDSC1; GDSC2 5.3953 7.3362 2.6684 0.8095
T.T GDSC1 5.6444 9.1048 2.9224 7.0139
KYSE-520 GDSC1; GDSC2 5.785 15.7378 -0.2173 19.9235
TE-15 GDSC1; GDSC2 5.8227 11.7476 1.7733 10.9023
KYSE-410 GDSC1; GDSC2 6.4686 8.1361 3.7738 0.3973
TE-1 GDSC1; GDSC2 6.4914 8.7721 3.5402 1.1039
TE-4 GDSC1; GDSC2 6.7132 8.6678 3.6756 0.5338
KYSE-270 GDSC1; GDSC2 6.8012 9.26 3.4868 1.0566
KYSE-180 GDSC1; GDSC2 6.9407 8.7048 3.7502 0.2753
TE-8 GDSC1; GDSC2 7.1616 13.9632 1.6124 9.1658
TE-5 GDSC1; GDSC2 7.3386 17.3382 0.124 15.3729
OE19 GDSC1; GDSC2 8.0841 18.0134 -0.5365 11.8517
KYSE-70 GDSC1; GDSC2 8.1656 18.0421 0.3397 13.033
COLO 680N GDSC1; GDSC2 8.5381 21.1375 -0.8848 16.9014
KYSE-140 GDSC1; GDSC2 8.5954 21.1421 -0.8486 16.6824
KYSE-150 GDSC1 9.1333 19.2787 0.3713 13.9464
KYSE-510 GDSC1; GDSC2 11.4134 26.1197 -1.3872 14.1869
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-OV-3 GDSC1; GDSC2 -3.3995 2.4407 -3.7929 62.5959
Caov-3 GDSC1; GDSC2 0.6487 4.8238 -0.1088 30.5949
JHOS-2 GDSC1; GDSC2 0.8399 5.0405 0.007 29.157
Caov-4 GDSC1 1.5209 4.2965 0.0209 9.9239
EFO-21 GDSC1; GDSC2 2.4003 9.4388 -0.5348 25.3804
OC 314 GDSC1 3.0018 4.6975 0.7768 1.0807
RMG-I GDSC1 3.4681 5.9155 0.5034 1.9464
OVKATE GDSC1 3.5959 12.8822 -2.6637 19.9654
OV56 GDSC1; GDSC2 3.6507 5.1219 2.6791 3.2079
FU-OV-1 GDSC1 3.7786 5.7901 0.6897 0.784
JHOS-4 GDSC1; GDSC2 3.8361 15.5527 -2.3704 27.5548
A2780 GDSC1; GDSC2 4.2222 6.0267 2.6258 2.3757
OVISE GDSC1; GDSC2 4.2818 15.4867 -1.9803 25.201
TYK-nu GDSC1; GDSC2 4.637 6.4038 2.6898 1.4365
ES-2 GDSC1; GDSC2 5.1347 6.7829 2.7692 0.6433
OVCAR-5 GDSC1; GDSC2 5.1844 7.3683 2.5595 1.4242
OAW42 GDSC1; GDSC2 5.2458 11.3558 0.7732 10.9407
TOV-21G GDSC1; GDSC2 5.4259 16.599 -1.6552 21.3519
IGROV-1 GDSC1; GDSC2 5.49 8.3511 2.3017 2.2627
OVK18 GDSC1; GDSC2 5.5488 11.5175 0.8983 9.6448
OVCAR-4 GDSC1; GDSC2 5.6494 7.5512 2.6931 0.5709
DOV13 GDSC1; GDSC2 5.6783 7.1351 2.8529 0.1877
OV-90 GDSC1; GDSC2 5.7227 10.9728 1.264 7.3454
OVTOKO GDSC1; GDSC2 5.7772 16.6045 -1.4009 19.6498
OAW28 GDSC1; GDSC2 6.0532 9.3803 2.1525 2.3128
TOV-112D GDSC1; GDSC2 6.346 12.7847 0.8103 8.6141
Kuramochi GDSC1; GDSC2 7.1494 18.337 -1.2853 16.4436
OVCAR-3 GDSC1; GDSC2 8.0494 20.2257 -1.5896 15.9463
EFO-27 GDSC1; GDSC2 8.9293 20.768 -1.289 13.4302
OVCAR-8 GDSC1; GDSC2 12.1143 31.6601 -4.3623 18.0152
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 03.27 GDSC1 -4.0786 0.7818 -4.4285 62.6655
Hs 766T GDSC1 3.3851 5.0835 0.7928 0.6759
HPAC GDSC1; GDSC2 3.8771 7.581 1.6355 9.135
SW1990 GDSC1 3.8774 8.1072 -0.2219 5.6483
PaTu 8902 GDSC1; GDSC2 4.5715 6.5689 2.5835 2.0571
HuP-T3 GDSC1; GDSC2 4.5823 7.8595 1.9979 5.34
SU.86.86 GDSC1; GDSC2 4.5996 6.45 2.6506 1.6757
KP-2 GDSC2 4.6867 6.4033 2.7151 1.2599
Panc 02.03 GDSC1; GDSC2 4.7531 7.904 2.0854 4.5104
BxPC-3 GDSC1; GDSC2 4.9024 10.108 1.1386 9.6661
DAN-G GDSC1; GDSC2 4.9096 7.1301 2.5215 1.915
HPAF-II GDSC1; GDSC2 4.9502 8.1927 2.0725 4.2367
SUIT-2 GDSC1; GDSC2 5.2038 6.6632 2.8423 0.381
QGP-1 GDSC1; GDSC2 5.2283 7.1066 2.6846 0.8761
PaTu 8988t GDSC1; GDSC2 5.2321 6.6169 2.87 0.2982
PSN1 GDSC1; GDSC2 5.3184 6.9991 2.7641 0.5446
KP-1N GDSC1; GDSC2 5.4132 7.7852 2.4986 1.4581
Capan-1 GDSC1; GDSC2 5.4237 7.8772 2.466 1.5876
MIA PaCa-2 GDSC1; GDSC2 5.43 6.7839 2.8848 0.1988
KP-4 GDSC1; GDSC2 5.6614 7.1768 2.8324 0.2289
Panc 08.13 GDSC1; GDSC2 5.6621 7.5272 2.707 0.5244
AsPC-1 GDSC1; GDSC2 5.8362 7.745 2.6961 0.4695
Panc 10.05 GDSC1; GDSC2 6.1209 8.2708 2.6161 0.5464
MZ-PC-1 GDSC1; GDSC2 6.1632 15.1908 -0.4441 14.9519
Panc 04.03 GDSC1 6.278 17.4994 -3.0753 15.7369
PL4 GDSC1; GDSC2 6.3928 13.8982 0.3215 10.9574
KP-3 GDSC1; GDSC2 6.6903 14.237 0.3509 10.2734
HuP-T4 GDSC1; GDSC2 6.8537 14.8298 0.1773 10.8051
Capan-2 GDSC1; GDSC2 9.3201 24.2451 -2.663 17.3813
YAPC GDSC1; GDSC2 9.5446 20.7238 -0.9032 11.0949
CFPAC-1 GDSC1; GDSC2 9.6267 22.4705 -1.6478 13.6516
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1; GDSC2 4.4669 7.5218 2.0824 5.0715
NCI-H2452 GDSC1 4.7111 6.5963 0.7529 0.2128
MSTO-211H GDSC1; GDSC2 4.8343 6.8724 2.5923 1.6646
IST-Mes1 GDSC1; GDSC2 5.0029 7.7739 2.2916 2.9606
NCI-H2052 GDSC1; GDSC2 5.4331 7.115 2.7674 0.4724
NCI-H28 GDSC1; GDSC2 7.6493 19.4507 -1.4839 16.2658
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1; GDSC2 4.817 7.7333 2.2026 3.7373
NCI-H660 GDSC2 4.9246 6.418 2.8194 0.6165
DU145 GDSC1; GDSC2 5.1287 7.0119 2.6773 0.9859
VCaP GDSC1; GDSC2 5.7572 15.7657 -1.0057 18.1687
PC-3 GDSC1; GDSC2 5.8805 9.1949 2.144 2.5448
22Rv1 GDSC1; GDSC2 7.8841 21.2991 -2.2078 18.3305
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 10.6364 23.0076 -1.3006 11.0613
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A101D GDSC1; GDSC2 -1.5058 5.6193 -2.7136 48.9947
Hs 940.T GDSC2 1.3537 7.1286 -0.3959 28.7355
WM1552C GDSC1; GDSC2 1.9357 10.6885 -1.572 30.8751
SK-MEL-1 GDSC1 3.064 11.2767 -2.2628 19.5638
SK-MEL-31 GDSC2 3.3114 17.9542 -4.003 32.8615
IST-MEL1 GDSC1 3.5764 8.4284 -0.5455 8.3382
RPMI-7951 GDSC1; GDSC2 3.6337 5.884 2.2906 5.6769
SK-MEL-28 GDSC1; GDSC2 3.757 15.6097 -2.4632 28.0309
IPC-298 GDSC1; GDSC2 3.9601 11.1792 -0.0884 18.5234
SK-MEL-3 GDSC1; GDSC2 4.097 7.592 1.7933 7.6253
COLO 783 GDSC1; GDSC2 4.3181 8.3428 1.5855 8.3674
WM115 GDSC1; GDSC2 4.3297 6.8972 2.2882 4.128
MMAc-SF GDSC1; GDSC2 4.335 7.905 1.8099 6.979
G-361 GDSC1; GDSC2 4.4299 16.7833 -2.5092 26.4514
Mel Ho GDSC1; GDSC2 4.5386 14.7489 -1.412 22.5907
MZ-MEL-7 GDSC1; GDSC2 4.575 7.272 2.2678 3.7886
WM793 GDSC1; GDSC2 4.5811 17.0243 -2.5102 26.0865
CHL-1 GDSC1; GDSC2 4.631 9.923 1.0386 10.8423
A2058 GDSC1; GDSC2 4.6494 17.3616 -2.6246 26.2532
SK-MEL-24 GDSC1; GDSC2 4.6696 7.6965 2.1298 4.4078
G-mel GDSC1; GDSC2 4.7739 14.239 -0.9788 20.3384
HT-144 GDSC1; GDSC2 4.7843 7.5746 2.2553 3.499
UACC-62 GDSC1; GDSC2 4.9425 6.1063 2.9425 0.2436
MZ-MEL-2 GDSC1; GDSC2 4.953 7.6362 2.3246 2.8598
VMRC-MELG GDSC2 4.9589 14.6662 -1.0505 20.1763
A-431 GDSC1; GDSC2 5.0617 13.9506 -0.6214 18.1521
GAK GDSC1; GDSC2 5.1493 6.7104 2.8028 0.5248
DJM-1 GDSC1; GDSC2 5.1578 16.9829 -2.0454 23.2894
LB2518-MEL GDSC1; GDSC2 5.1668 6.7417 2.7983 0.5284
CP66-MEL GDSC1; GDSC2 5.2391 6.7266 2.833 0.3889
IGR-37 GDSC1; GDSC2 5.2889 6.5365 2.9196 0.1755
RVH-421 GDSC1; GDSC2 5.3161 6.9652 2.7758 0.5107
COLO 679 GDSC1; GDSC2 5.3181 7.585 2.5349 1.3967
COLO 792 GDSC2 5.3369 13.1827 -0.0468 14.9055
LB373-MEL-D GDSC1; GDSC2 5.3609 6.7861 2.8585 0.2749
UACC-257 GDSC1; GDSC2 5.3623 6.685 2.8946 0.2004
451Lu GDSC1; GDSC2 5.4618 14.4543 -0.5773 17.0381
Mel JuSo GDSC1; GDSC2 5.5635 7.006 2.8562 0.2133
WT2-iPS GDSC1; GDSC2 5.5716 16.2265 -1.365 19.9692
HMV-II GDSC1; GDSC2 5.6355 8.113 2.4702 1.3674
LOX-IMVI GDSC1; GDSC2 5.6786 12.5873 0.4756 11.5902
IGR-1 GDSC1; GDSC2 5.7487 7.3203 2.8142 0.2372
WM278 GDSC1; GDSC2 5.7697 7.8399 2.6345 0.6786
SH-4 GDSC1; GDSC2 5.9024 7.8197 2.6947 0.4435
MeWo GDSC1 6.3033 17.8505 -3.223 16.2704
COLO 829 GDSC1; GDSC2 6.3434 14.5797 -0.0319 12.7294
SK-MEL-2 GDSC1; GDSC2 6.5987 18.4792 -0.9605 20.7977
CP50-MEL-B GDSC1; GDSC2 6.6084 14.8911 -0.0067 12.107
SK-MEL-30 GDSC1; GDSC2 6.7075 20.0999 -2.4404 21.2513
A-388 GDSC1; GDSC2 6.8464 15.9346 0.4611 14.9463
A-375 GDSC1; GDSC2 7.1685 16.1837 -0.2557 12.2082
COLO 800 GDSC1; GDSC2 8.0552 23.652 -3.2201 21.0527
M14 GDSC1; GDSC2 8.2346 21.4229 -2.0348 17.1591
Hs 938.T GDSC1; GDSC2 8.8456 26.9796 -4.2801 22.4467
SK-MEL-5 GDSC1; GDSC2 9.2869 21.8464 -1.5673 13.8775
EquiPSC Line K2 GDSC2 5.7369 16.0728 -1.1701 18.862
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 7.6519 17.8638 -0.7351 13.3843
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW872 GDSC1; GDSC2 -4.5964 7.012 -6.5478 62.682
KYM-1 GDSC1; GDSC2 -4.4373 -3.698 -4.4373 79.8791
GCT GDSC1; GDSC2 -0.3832 5.5205 -1.4792 40.7311
Rh18 GDSC1 2.3782 6.8284 -0.582 11.6653
STS-0421 GDSC2 2.9059 6.4533 1.3973 13.4081
Hs 633.T GDSC1 3.7311 5.3609 0.8271 0.3698
G-401 GDSC1; GDSC2 4.2236 6.487 2.4129 3.6009
MES-SA GDSC1; GDSC2 4.275 6.0689 2.6379 2.2196
SW982 GDSC1; GDSC2 4.4301 6.4516 2.5557 2.421
RKN GDSC1; GDSC2 4.6322 8.0557 1.9376 5.5952
TE 441.T GDSC1; GDSC2 4.6869 5.9988 2.8785 0.5801
SW684 GDSC1; GDSC2 4.7808 11.2275 0.5091 13.3948
Rh41 GDSC1; GDSC2 4.8257 6.5926 3.5741 3.14
Rh30 GDSC1; GDSC2 4.8641 7.3536 3.2307 4.9827
SK-LMS-1 GDSC1; GDSC2 5.1157 9.6133 1.516 7.0835
VA-ES-BJ GDSC1; GDSC2 5.3169 7.3495 2.6287 1.0164
A-204 GDSC1; GDSC2 5.3598 8.2116 3.1592 4.3927
EW-8 GDSC1; GDSC2 5.4355 8.4922 3.0758 4.7043
SK-UT-1 GDSC1; GDSC2 5.6458 7.4578 2.7261 0.48
HT-1080 GDSC1; GDSC2 6.0488 7.7614 3.7403 0.736
RD GDSC1; GDSC2 6.2159 9.6725 3.0116 3.7603
MFH-ino GDSC1 6.6432 13.0256 1.7193 12.4595
G-402 GDSC1; GDSC2 8.9943 23.6973 -2.6151 17.7486
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TMK-1 GDSC2 -1.1674 7.3231 -3.0455 47.1909
SNU-16 GDSC1 3.1633 4.4228 0.9467 0.2999
AGS GDSC1; GDSC2 3.7724 9.2074 0.7457 14.6813
HSC-39 GDSC1 3.8846 5.529 0.8247 0.3137
SK-GT-2 GDSC2 4.0931 7.4254 1.872 7.1536
NUGC-3 GDSC1; GDSC2 4.38 6.2768 2.6053 2.2295
ECC12 GDSC2 4.7317 6.2101 2.8154 0.7835
TGBC11TKB GDSC1; GDSC2 4.8042 11.389 0.4471 13.6653
MKN45 GDSC1; GDSC2 4.8288 5.755 3.0239 0.1169
23132/87 GDSC1; GDSC2 4.9525 6.8739 2.6506 1.264
ECC10 GDSC1; GDSC2 4.9865 10.7199 0.9015 10.8053
NCI-N87 GDSC1; GDSC2 5.0385 7.1664 2.5717 1.5251
SCH GDSC1; GDSC2 5.0933 6.777 2.7537 0.7265
SNU-5 GDSC1; GDSC2 5.1659 7.007 2.696 0.8831
KATO III GDSC1; GDSC2 5.2048 11.5845 0.635 11.7657
MKN28 GDSC1; GDSC2 5.3536 7.8349 2.4494 1.7347
HGC-27 GDSC1; GDSC2 5.3699 7.1397 2.7325 0.612
OCUM-1 GDSC1; GDSC2 5.3865 9.2067 1.87 4.6272
MKN1 GDSC2 5.4535 7.6763 2.561 1.1651
NUGC-4 GDSC1; GDSC2 5.687 7.6276 2.6799 0.589
RF-48 GDSC1; GDSC2 5.7538 7.5646 2.7294 0.4216
RERF-GC-1B GDSC1; GDSC2 5.8256 16.9952 -1.557 20.1166
SNU-1 GDSC1; GDSC2 6.0381 7.6394 2.808 0.1739
Fu97 GDSC1 6.2205 23.5442 -5.9921 24.9198
MKN7 GDSC1; GDSC2 6.7311 9.3733 3.4099 1.3874
GCIY GDSC1; GDSC2 6.7549 15.4654 -0.1827 12.6349
IM95 GDSC1; GDSC2 7.8925 19.2071 -1.2113 14.8312
Hs 746.T GDSC1; GDSC2 9.2033 27.7951 -3.6374 23.3639
SNG-M GDSC1; GDSC2 5.9018 11.4599 1.9684 9.7323
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TT GDSC1 3.4089 5.1813 0.766 0.7619
CGTH-W-1 GDSC1 3.5089 5.279 0.7704 0.6729
K5 GDSC1; GDSC2 4.4573 6.8241 2.4022 3.2316
BHT-101 GDSC1; GDSC2 4.5697 6.2472 2.7217 1.3653
B-CPAP GDSC1; GDSC2 4.6737 8.9481 1.5401 7.8459
KMH-2 GDSC1; GDSC2 4.8799 7.3008 2.4318 2.406
CAL-62 GDSC1; GDSC2 4.9177 6.483 2.7912 0.7231
IHH-4 GDSC1; GDSC2 4.9961 7.0176 2.6125 1.3867
8305C GDSC1; GDSC2 5.0531 8.3225 2.0746 4.0535
HTC-C3 GDSC1; GDSC2 5.184 7.5205 2.4963 1.7079
ASH-3 GDSC1; GDSC2 5.5225 7.097 2.8088 0.326
FTC-133 GDSC2 5.5763 7.2937 2.7586 0.4267
TT2609-C02 GDSC1; GDSC2 5.5887 7.5835 2.656 0.7209
ML-1 [Human leukemia] GDSC1; GDSC2 5.7741 7.5649 2.7371 0.394
WRO GDSC2 6.4981 17.7238 -1.4346 18.2657
8505C GDSC1; GDSC2 6.6882 8.2706 2.8194 0.0671
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SKN-3 GDSC1; GDSC2 -1.0535 8.1747 -3.2961 46.7603
BB30-HNC GDSC1; GDSC2 2.944 10.1226 -0.3983 22.9771
KOSC-2 GDSC1; GDSC2 3.0738 8.0761 0.7351 16.7956
PCI-38 GDSC1 3.7782 5.7428 0.7071 0.7206
JHU-011 GDSC1; GDSC2 3.8323 7.2497 1.7655 8.4476
DOK GDSC1; GDSC2 3.8472 11.6448 -0.4103 20.3394
HO-1-u-1 GDSC1 3.9566 5.8573 0.7354 0.5222
SAS GDSC1; GDSC2 3.9732 5.9197 2.5175 3.4815
PCI-15A GDSC1; GDSC2 4.1837 7.6801 1.8126 7.3045
Detroit 562 GDSC1; GDSC2 4.1877 6.4116 2.4253 3.5976
FaDu GDSC1; GDSC2 4.267 12.0033 -0.2585 18.5062
OSC-19 GDSC1; GDSC2 4.469 10.6013 0.5883 13.7266
HSC-4 GDSC1; GDSC2 4.6322 6.3571 2.7071 1.36
HO-1-N-1 GDSC1; GDSC2 4.6737 8.6775 1.6697 7.0849
HSC-2 GDSC1; GDSC2 4.7374 11.5385 0.3253 14.456
SCC-15 GDSC1; GDSC2 4.785 7.7495 2.176 3.9402
SCC-4 GDSC2 4.9722 8.4732 1.9572 4.8464
BB49-HNC GDSC1; GDSC2 4.9812 7.7431 2.2931 2.9848
BICR 10 GDSC1; GDSC2 5.2623 15.3292 -1.1514 19.8565
HSC-3 GDSC1; GDSC2 5.3401 14.3977 -0.6374 17.5732
OSC-20 GDSC1; GDSC2 5.3402 8.1391 2.3147 2.3831
CAL-33 GDSC1; GDSC2 5.3789 7.3182 2.6683 0.8218
SAT [Human HNSCC] GDSC1; GDSC2 5.3956 9.9778 1.5225 6.5222
PCI-04B GDSC1; GDSC2 5.5109 18.6854 -2.6206 24.2739
UPCI-SCC-090 GDSC2 5.633 8.7746 2.1954 2.5971
SCC-25 GDSC1; GDSC2 5.8678 8.1499 2.5582 0.8616
BHY GDSC1; GDSC2 5.9093 8.3074 2.5156 0.9781
PE/CA-PJ15 GDSC1; GDSC2 5.9606 7.9784 2.6598 0.5066
BICR 78 GDSC1; GDSC2 5.9667 8.3044 2.5411 0.8538
JHU-029 GDSC2 6.0369 8.1925 2.6116 0.5998
LB771-HNC GDSC1; GDSC2 6.0493 8.2209 2.606 0.6089
NCI-H3118 GDSC1; GDSC2 6.1316 8.2263 2.6364 0.4893
Ca9-22 GDSC1; GDSC2 6.4294 8.7073 2.5778 0.5067
PCI-06A GDSC1; GDSC2 6.4492 8.6527 2.6049 0.4355
BICR 31 GDSC1; GDSC2 7.0348 18.3529 -1.3698 16.9756
KON GDSC1; GDSC2 8.2114 19.9437 -1.3533 14.8187
BICR 22 GDSC1; GDSC2 8.2573 20.5866 -1.6255 15.721
JHU-022 GDSC1; GDSC2 8.5817 22.688 -2.4067 17.7758
CAL-27 GDSC1; GDSC2 9.3748 22.2295 -1.6901 14.1703
SCC-9 GDSC1; GDSC2 10.0658 25.8729 -2.9512 17.1075
PCI-30 GDSC1 10.1818 27.0035 -2.5856 22.0525
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
639V GDSC1; GDSC2 3.6968 5.3041 2.6232 3.4457
BFTC-905 GDSC1; GDSC2 4.3628 5.9933 2.7215 1.6373
UM-UC-3 GDSC1 4.3922 13.3348 -2.3311 16.4758
KU-19-19 GDSC1; GDSC2 4.5984 7.8427 2.0162 5.2013
J82 GDSC1; GDSC2 4.6903 7.0239 2.4486 2.5945
SW780 GDSC1; GDSC2 5.0056 10.5581 0.9927 10.2595
TCCSUP GDSC1; GDSC2 5.1361 6.7917 2.7665 0.6518
CAL-29 GDSC1; GDSC2 5.2778 7.2156 2.6639 0.9144
647V GDSC1; GDSC2 5.4417 6.7241 2.9097 0.1529
RT-112 GDSC1; GDSC2 5.5135 6.8714 2.8847 0.1763
RT-4 GDSC1; GDSC2 5.7464 7.3767 2.7936 0.2784
HT-1376 GDSC1; GDSC2 5.9857 11.9833 0.9587 8.4926
T24 GDSC1; GDSC2 5.986 7.9755 2.6707 0.4671
5637 GDSC1; GDSC2 6.3578 8.501 2.6244 0.4261
SW1710 GDSC1; GDSC2 6.426 11.2656 1.5413 4.7727
HT-1197 GDSC1; GDSC2 7.3244 16.7086 -0.4024 12.5686
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1; GDSC2 1.7649 17.9156 -5.3098 38.953
HT-3 GDSC1; GDSC2 1.8181 9.9826 -1.3319 30.5071
NCC-IT GDSC1 2.6507 11.3221 -2.5933 22.2915
NT2-D1 GDSC1 3.3516 5.1692 0.7465 0.8874
PA-1 GDSC1; GDSC2 3.6904 7.9318 1.3164 11.5743
OVCA420 GDSC1 3.9607 5.9367 0.7083 0.6043
CAL-39 GDSC1; GDSC2 3.9659 6.8362 2.0683 6.2451
HeLa GDSC1; GDSC2 4.156 5.2527 2.9311 0.8631
SW954 GDSC1; GDSC2 4.1752 6.1888 2.5219 3.0553
KGN GDSC1 4.5087 6.6644 0.6566 0.4835
PEO1 GDSC1; GDSC2 4.5178 8.2312 1.7782 6.7719
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 4.5638 10.0973 0.9052 11.7526
HEY GDSC1; GDSC2 4.5703 6.5061 2.6104 1.9192
PWR-1E GDSC1; GDSC2 4.6214 8.0235 1.9458 5.5687
ME-180 GDSC1; GDSC2 4.6988 9.6999 1.1947 9.7965
NEC8 GDSC1; GDSC2 4.7322 6.495 2.6995 1.2804
DSH1 GDSC1; GDSC2 5.007 7.8271 2.2703 3.0673
SKN GDSC1; GDSC2 5.0197 7.4961 2.4222 2.2644
OV17R GDSC1; GDSC2 5.2041 10.3592 1.2211 8.57
HEC-1 GDSC1; GDSC2 5.3082 6.8854 2.8022 0.439
SW756 GDSC1; GDSC2 5.3355 7.3344 2.6429 0.9472
MS751 GDSC1; GDSC2 5.3431 8.6044 2.1142 3.3926
C-4-I GDSC1; GDSC2 5.3675 7.4997 2.5921 1.1165
SiHa GDSC1; GDSC2 5.4966 6.9571 2.8487 0.2484
SW962 GDSC1; GDSC2 5.5026 7.1881 2.7682 0.4359
DoTc2 4510 GDSC1; GDSC2 5.6772 15.0791 -0.7282 17.2046
UWB1.289 GDSC1; GDSC2 5.7643 12.7046 0.4767 11.4099
OVCA433 GDSC1; GDSC2 5.7694 8.4658 2.3905 1.5709
JHOS-3 GDSC1; GDSC2 5.8424 7.6715 2.725 0.3949
TC-YIK GDSC1; GDSC2 5.9029 7.9105 2.6619 0.5284
OVMIU GDSC1; GDSC2 6.2903 9.3652 2.2704 1.5888
ACC-OV7 GDSC1; GDSC2 6.3091 8.9946 2.4228 1.0206
JAR GDSC1; GDSC2 6.3198 7.7519 3.8551 0.2709
LB831-BLC GDSC1; GDSC2 6.4663 18.2479 -0.9448 21.0204
Ca Ski GDSC1; GDSC2 6.8209 9.183 2.5562 0.4085
C-33 A GDSC1; GDSC2 7.1555 9.2826 3.6254 0.4605
SKG-IIIa GDSC1; GDSC2 7.2525 18.7556 -0.6225 18.3315
SiSo GDSC1; GDSC2 8.715 18.2102 0.6079 11.0598
JEG-3 GDSC1; GDSC2 8.8856 20.6028 -0.4019 14.6482
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7912).
3 National Cancer Institute Drug Dictionary (drug id 670651).
4 The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells. Toxicol Appl Pharmacol. 2020 Aug 15;401:115080. doi: 10.1016/j.taap.2020.115080. Epub 2020 Jun 1.