Details of the Drug

General Information of Drug (ID: DMTOI7S)

Drug Name
ARRY-520
Synonyms
Filanesib; ARRY-520; 885060-09-3; UNII-8A49OSO368; Arry520; CHEMBL2347655; ARRY 520 trifluoroacetate; 8A49OSO368; ARRY 520; (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide; Filanesib [INN]; Filanesib [USAN:INN]; C20H22F2N4O2S; ARRY-520; Filanesib; 1385020-40-5; Filanesib(ARRY-520); SCHEMBL368043; DTXSID50237086; EX-A678; BCP07442; ZINC43204022; 3452AH; BDBM50431893; AKOS030526964; SB19209; RL05514; CS-0867; NCGC00381751-02; NCGC00381751-04
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 420.5
Logarithm of the Partition Coefficient (xlogp) 3.3
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C20H22F2N4O2S
IUPAC Name
(2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
Canonical SMILES
CN(C(=O)N1[C@](SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)OC
InChI
InChI=1S/C20H22F2N4O2S/c1-25(28-2)19(27)26-20(11-6-12-23,14-7-4-3-5-8-14)29-18(24-26)16-13-15(21)9-10-17(16)22/h3-5,7-10,13H,6,11-12,23H2,1-2H3/t20-/m0/s1
InChIKey
LLXISKGBWFTGEI-FQEVSTJZSA-N
Cross-matching ID
PubChem CID
44224257
CAS Number
885060-09-3
UNII
8A49OSO368
DrugBank ID
DB06040
TTD ID
D04VWJ
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kinesin-like protein KIF11 (KIF11) TTTRP0H KIF11_HUMAN Inhibitor [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Multiple myeloma
ICD Disease Classification 2A83
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Kinesin-like protein KIF11 (KIF11) DTT KIF11 5.72E-26 -1.17 -1.31
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 0.9846 8.3252 -4.9093 12.9058
EW-13 GDSC1 -9.2246 -8.0645 -9.2246 89.2855
ES7 GDSC1 -8.5996 -7.2039 -8.5996 82.0484
HuO9 GDSC1 -8.518 -1.977 -9.1134 67.9753
ES8 GDSC1 -8.5066 -7.5713 -8.5066 81.5905
ES1 GDSC1 -8.3825 -6.8314 -8.3826 79.3195
EW-18 GDSC1 -8.218 -6.1527 -8.2204 76.4668
CAL-78 GDSC1 -8.0024 5.9817 -11.6531 57.6873
EW-16 GDSC1 -7.8399 -6.4854 -7.84 73.186
EW-22 GDSC1 -7.8166 0.7143 -9.241 60.8059
HOS GDSC1 -7.3703 -4.7389 -7.3963 66.0974
SK-PN-DW GDSC1 -7.3395 -4.4255 -7.3848 65.3138
NY GDSC1 -7.3319 -5.3691 -7.3363 66.5332
SK-ES-1 GDSC1 -7.2555 -5.6128 -7.2567 65.8834
SaOS-2 GDSC1 -7.2239 -2.625 -7.5385 61.5163
NOS-1 [Human HNSCC] GDSC1 -7.055 -1.5989 -7.6242 59.0021
TC-71 GDSC1 -6.7621 -5.4904 -6.7623 59.9268
MG-63 GDSC1 -6.6523 -1.3656 -7.256 55.824
CADO-ES1 GDSC1 -6.5458 -3.9862 -6.5907 56.7803
EW-3 GDSC1 -6.49 -2.1932 -6.843 55.0397
EW-7 GDSC1 -6.2162 -1.4254 -6.7625 52.2669
A-673 GDSC1 -6.152 4.9668 -9.3316 50.8747
MHH-ES-1 GDSC1 -5.2472 -1.1849 -5.787 42.9028
SJSA-1 GDSC1 -4.608 7.8382 -9.2127 44.2689
HuO-3N1 GDSC1 -3.8863 7.6691 -8.4644 40.6705
U2OS GDSC1 -3.4361 5.3617 -6.917 35.7722
CAL-72 GDSC1 -3.2979 4.7234 -6.4764 33.9
EW-1 GDSC1 -0.3798 14.3831 -8.859 30.8129
ES4 GDSC1 -0.1803 9.3708 -6.2236 22.2026
ES6 GDSC1 0.2311 5.9659 -4.2842 11.0419
G-292 clone A141B1 GDSC1 0.8374 18.27 -9.8531 30.138
CHSA8926 GDSC1 1.1698 12.134 -6.6044 20.3062
EW-24 GDSC1 2.0025 15.7921 -7.7946 22.5683
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 152 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -8.1567 -6.7647 -8.1568 76.9437
MOLP-8 GDSC1 -13.3138 1.5674 -15.4677 74.2115
H9 GDSC1 -11.726 -3.9956 -12.1398 81.8181
SU-DHL-16 GDSC1 -10.8655 -7.8788 -10.8694 92.9561
Jurkat GDSC1 -9.8105 -0.2224 -11.0594 69.5742
GA-10 GDSC1 -9.7074 -5.137 -9.8057 80.9338
SU-DHL-5 GDSC1 -9.6499 -8.9744 -9.6499 94.8758
SU-DHL-10 GDSC1 -9.6082 -8.3328 -9.6082 92.3969
BC-1 GDSC1 -9.4765 -8.2207 -9.4765 91.3547
Karpas-620 GDSC1 -9.4567 -3.6453 -9.7511 75.6405
LC4-1 GDSC1 -9.4176 1.7491 -11.3464 65.6394
SUP-B15 GDSC1 -9.3753 -8.09 -9.3753 90.3464
MOLT-13 GDSC1 -9.3296 -8.1722 -9.3296 90.3261
NU-DUL-1 GDSC1 -9.3045 -2.6037 -9.81 72.51
BALL-1 GDSC1 -9.2654 -8.2262 -9.2654 90.0337
NKM-1 GDSC1 -9.2492 -8.2339 -9.2492 89.9317
JSC-1 GDSC1 -9.2068 -7.5255 -9.2069 87.4963
P30/OHK GDSC1 -9.1861 -8.1825 -9.1861 89.3018
CML-T1 GDSC1 -9.157 -3.1647 -9.522 73.2995
Sc-1 GDSC1 -9.1289 -8.0207 -9.1289 88.441
Reh GDSC1 -9.0442 -8.1163 -9.0442 87.9156
SUP-M2 GDSC1 -9.0362 -0.7602 -10.0419 67.9015
SU-DHL-6 GDSC1 -9.0202 -6.8479 -9.0218 84.1715
SR GDSC1 -8.9751 -6.0542 -8.9887 81.2473
BV-173 GDSC1 -8.8918 -7.6897 -8.8918 85.6767
MV4-11 GDSC1 -8.8755 -7.9818 -8.8755 86.0341
OCI-AML-2 GDSC1 -8.7598 -7.7493 -8.7598 84.5217
NALM-6 GDSC1 -8.7481 -7.4678 -8.7481 83.9294
ST486 GDSC1 -8.7162 -7.4953 -8.7162 83.6835
RS4;11 GDSC1 -8.7056 -7.4784 -8.7056 83.5524
697 GDSC1 -8.6992 -7.7512 -8.6992 83.8883
RPMI-8866 GDSC1 -8.6894 -7.2956 -8.6894 83.05
NB4 GDSC1 -8.6658 -7.8708 -8.6658 83.6275
CCRF-CEM GDSC1 -8.6173 -7.5181 -8.6173 82.7351
MY-M12 GDSC1 -8.6148 -7.4682 -8.6148 82.6405
ML-2 GDSC1 -8.6082 -7.7617 -8.6082 82.89
ALL-PO GDSC1 -8.6023 -7.093 -8.6024 81.8516
OCI-Ly19 GDSC1 -8.5807 -3.3188 -8.8655 71.1923
Loucy GDSC1 -8.5487 -7.3572 -8.5487 81.8071
Ramos.2G6.4C10 GDSC1 -8.5441 -6.9262 -8.5443 80.9836
KE-37 GDSC1 -8.5436 -7.5812 -8.5436 82.0137
RPMI-6666 GDSC1 -8.501 -6.2503 -8.5045 78.9647
RPMI-8402 GDSC1 -8.496 -7.1464 -8.496 80.9566
OPM-2 GDSC1 -8.4895 -7.0847 -8.4895 80.7894
OCI-AML-3 GDSC1 -8.4855 -7.3195 -8.4855 81.101
Karpas-45 GDSC1 -8.4781 -7.0504 -8.4781 80.6203
QIMR-WIL GDSC1 -8.4777 -7.1165 -8.4777 80.7276
CTB-1 GDSC1 -8.4674 15.2711 -16.4609 55.699
KCL-22 GDSC1 -8.4509 -6.8232 -8.4512 79.939
MOLM-13 GDSC1 -8.4421 -6.4651 -8.4435 79.0638
Ku812 GDSC1 -8.3627 -6.902 -8.3628 79.2485
U-698-M GDSC1 -8.3176 -7.1137 -8.3176 79.068
THP-1 GDSC1 -8.3141 -7.024 -8.3142 78.9267
HDLM-2 GDSC1 -8.3135 2.8474 -10.6151 60.8271
DEL GDSC1 -8.2998 -7.1788 -8.2998 78.9367
HC-1 GDSC1 -8.2416 -7.3251 -8.2416 78.3652
NOMO-1 GDSC1 -8.2354 -6.8566 -8.2354 77.8875
MHH-PREB-1 GDSC1 -8.1956 -7.0304 -8.1956 77.641
IM-9 GDSC1 -8.1713 -7.0865 -8.1713 77.4084
SUP-HD1 GDSC1 -8.1626 1.7548 -10.013 61.2462
KOPN-8 GDSC1 -8.1619 -5.4268 -8.179 74.2772
L-363 GDSC1 -8.1591 -7.5398 -8.1591 77.4112
PF-382 GDSC1 -8.1108 -6.4462 -8.1112 76.0304
GDM-1 GDSC1 -8.0899 -4.4489 -8.1703 71.2717
DoHH2 GDSC1 -8.0761 -6.5215 -8.0764 75.789
ATN-1 GDSC1 -8.0536 -7.1109 -8.0536 76.0356
OCI-AML-5 GDSC1 -8.0355 -7.0326 -8.0355 75.789
CESS GDSC1 -7.9835 -6.6013 -7.9836 74.8926
TUR GDSC1 -7.9815 -6.1946 -7.9825 74.3533
RCH-ACV GDSC1 -7.9777 -6.9185 -7.9777 75.0517
RPMI-8226 GDSC1 -7.8765 -6.4134 -7.8767 73.5316
WIL2 NS GDSC1 -7.8405 -3.7975 -7.9857 68.0602
BL-41 GDSC1 -7.8398 -6.7169 -7.8398 73.3264
Jiyoye GDSC1 -7.8309 -2.3291 -8.2711 65.0719
TK [Human B-cell lymphoma] GDSC1 -7.754 0.8736 -9.2345 60.3537
SIG-M5 GDSC1 -7.7344 -6.9418 -7.7344 72.0979
HAL-01 GDSC1 -7.6886 -6.6484 -7.6886 71.4872
P12-Ichikawa GDSC1 -7.6592 -6.6449 -7.6592 71.1287
K-562 GDSC1 -7.6582 -0.1468 -8.7552 60.9724
MOLT-4 GDSC1 -7.5914 -5.8078 -7.593 69.8002
ALL-SIL GDSC1 -7.4813 -5.8837 -7.482 68.655
SCC-3 GDSC1 -7.4694 -6.4816 -7.4694 68.7739
HL-60 GDSC1 -7.4177 -6.318 -7.4177 68.1102
HH [Human lymphoma] GDSC1 -7.4151 11.3884 -13.5916 54.1491
SKM-1 GDSC1 -7.4066 -5.5873 -7.4089 67.564
P32/ISH GDSC1 -7.4027 -5.6425 -7.4045 67.5721
JJN-3 GDSC1 -7.3624 -4.4922 -7.4037 65.6319
MOLT-16 GDSC1 -7.2665 -3.4214 -7.4281 63.0526
CA46 GDSC1 -7.2163 0.5059 -8.5197 57.9833
VAL GDSC1 -7.1839 -1.2617 -7.8673 59.501
MC116 GDSC1 -7.1012 -5.5841 -7.1021 64.0632
Karpas-231 GDSC1 -7.09 -5.478 -7.0914 63.8813
KM-H2 GDSC1 -7.089 -1.292 -7.7545 58.9052
AMO1 GDSC1 -7.037 1.6023 -8.7619 56.2484
Karpas-422 GDSC1 -6.8631 20.7588 -17.6293 51.7689
PL-21 GDSC1 -6.8153 0.027 -7.9104 55.9899
KMS-12-BM GDSC1 -6.7473 -5.4235 -6.7478 59.7362
BC-3 GDSC1 -6.736 -4.8272 -6.7431 59.4114
DB GDSC1 -6.6001 1.3952 -8.2175 53.9589
Mono-Mac-6 GDSC1 -6.5734 -2.7262 -6.8088 56.1703
NK-92MI GDSC1 -6.5475 -3.2064 -6.69 56.2748
Farage GDSC1 -6.2843 0.4641 -7.5095 52.2779
KG-1 GDSC1 -6.1048 -3.8469 -6.1407 51.6675
L-428 GDSC1 -6.0345 7.4685 -10.3904 50.27
CTV-1 GDSC1 -5.9719 3.9177 -8.6704 50.0318
MEG-01 GDSC1 -5.9223 0.7065 -7.2227 49.6846
BE-13 GDSC1 -5.8053 4.0168 -8.5486 49.1578
LAMA-84 GDSC1 -5.7815 -0.3276 -6.6692 48.4634
Granta-519 GDSC1 -5.6446 4.3688 -8.5509 48.3436
JURL-MK1 GDSC1 -5.4743 -1.2551 -6.01 45.2274
Hs 445 GDSC1 -5.1561 0.2877 -6.2448 43.2716
HT GDSC1 -5.1351 17.4053 -14.4046 48.002
SU-DHL-8 GDSC1 -5.0209 9.9387 -10.6229 46.6318
DG-75 GDSC1 -4.783 0.9346 -6.129 40.5429
A3/Kawakami GDSC1 -4.647 6.5539 -8.6244 43.8743
OCI-M1 GDSC1 -4.2884 2.1797 -6.1912 37.8205
EM-2 GDSC1 -4.1846 4.6678 -7.2743 39.9034
SUP-T1 GDSC1 -3.8989 3.0981 -6.2462 35.9576
EJM GDSC1 -3.8559 3.1238 -6.2175 35.6535
VL51 GDSC1 -3.7051 -2.1542 -3.816 22.4604
KMOE-2 GDSC1 -3.6447 5.288 -7.0719 37.0548
DND-41 GDSC1 -3.5138 16.617 -12.5768 43.4508
U266B1 GDSC1 -3.1873 6.2442 -7.1284 35.3101
Raji GDSC1 -3.1682 48.996 -28.4555 47.0644
GR-ST GDSC1 -3.1593 7.4974 -7.7254 36.6171
Karpas-299 GDSC1 -2.7444 10.1953 -8.7068 37.1138
ARH-77 GDSC1 -2.6158 4.8177 -5.9134 29.0091
HEL GDSC1 -2.3787 1.7077 -4.157 18.4476
SU-DHL-4 GDSC1 -1.9146 5.9468 -5.8795 26.2008
KY821 GDSC1 -1.5445 7.9435 -6.5738 27.6663
L-540 GDSC1 -1.1193 10.0534 -7.2853 28.7059
KMS-11 GDSC1 -0.4286 12.325 -7.874 28.491
EB2 GDSC1 -0.3309 15.777 -9.5142 32.0618
L-1236 GDSC1 -0.1763 10.4941 -6.7745 24.3254
MN-60 GDSC1 -0.0254 10.8553 -6.8398 24.1562
SK-MM-2 GDSC1 0.0545 12.5346 -7.6089 26.4754
EoL-1 GDSC1 0.0577 23.363 -12.9859 36.3218
LP-1 GDSC1 0.1341 13.5055 -8.0287 27.4841
Daudi GDSC1 0.1638 10.0448 -6.302 21.5956
YT GDSC1 0.3252 4.6614 -3.6209 6.5881
WSU-DLCL2 GDSC1 0.3384 13.9042 -8.0719 27.105
ME1 GDSC1 0.3782 16.6421 -9.3957 30.1978
JVM-3 GDSC1 0.4669 13.5771 -7.8147 26.0654
SU-DHL-1 GDSC1 0.5795 1.7908 -2.3506 0.0678
ROS-50 GDSC1 0.7502 11.5447 -6.6131 21.3388
EHEB GDSC1 0.9004 11.7992 -6.6307 21.0429
RL GDSC1 1.0364 20.1019 -10.6084 31.1381
RC-K8 GDSC1 1.0492 17.8536 -9.4888 28.9434
P31/FUJ GDSC1 1.1562 12.599 -6.839 21.2206
MLMA GDSC1 1.1827 12.8399 -6.9372 21.5162
JVM-2 GDSC1 1.3109 3.4553 -2.6591 0.4175
WSU-NHL GDSC1 1.6512 14.1713 -7.255 21.5758
⏷ Show the Full List of 152 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FLO-1 GDSC1 -7.9812 -6.631 -7.9813 74.8951
ESO-26 GDSC1 -7.6037 3.7107 -10.2419 57.5202
OACP4 C GDSC1 -6.2884 -4.3677 -6.3007 53.9481
HCE-4 GDSC1 -5.1962 1.2569 -6.6949 44.3244
KYSE-50 GDSC1 -0.8707 19.9121 -12.006 37.0292
KYSE-220 GDSC1 -0.7235 9.182 -6.5412 25.0058
OACM5.1 C GDSC1 0.8282 11.9862 -6.7727 21.7513
SK-GT-4 GDSC1 0.8941 9.8532 -5.6952 17.0917
KYAE-1 GDSC1 0.8971 7.7032 -4.6736 11.7965
TE-12 GDSC1 1.9179 15.0773 -7.508 21.8422
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 -4.0749 36.5125 -22.9896 47.4531
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB1 GDSC1 -14.2174 5.9089 -18.0828 70.8404
NB69 GDSC1 -10.1747 -0.6836 -11.3048 71.3871
IMR-5 GDSC1 -9.6977 -2.1799 -10.3464 72.8926
SK-N-MC-IXC GDSC1 -8.8749 -6.9603 -8.8755 83.6283
CHP-134 GDSC1 -8.5342 -2.6566 -8.958 69.4458
KP-N-YS GDSC1 -8.4155 -6.7625 -8.4158 79.4962
CHP-212 GDSC1 -7.8051 8.8373 -12.7663 55.9066
SiMa GDSC1 -7.7778 -0.8478 -8.6457 62.4688
SJNB-5 GDSC1 -7.5646 -3.5554 -7.7268 65.6023
TGW GDSC1 -7.5501 -6.6065 -7.5501 69.7843
SK-N-SH GDSC1 -7.2742 -3.0568 -7.5018 62.5422
MHH-NB-11 GDSC1 -7.1811 -5.6433 -7.1819 65.0344
SJNB-10 GDSC1 -6.8669 -3.7947 -6.9485 59.9731
Kelly GDSC1 -6.8025 -4.736 -6.8134 60.1269
SJNB-14 GDSC1 -6.6919 -3.7623 -6.7668 58.179
NH-12 GDSC1 -6.622 -3.8404 -6.6845 57.5087
SJNB-12 GDSC1 -6.2996 0.1505 -7.4044 52.4703
SJNB-6 GDSC1 -5.7279 6.4762 -9.622 48.9735
NB(TU)1 GDSC1 -5.6358 1.5825 -7.2897 47.7601
SK-N-FI GDSC1 -5.3659 0.7294 -6.6473 45.381
SK-N-AS GDSC1 -5.0272 1.4038 -6.5849 43.0732
GOTO GDSC1 -4.1637 22.3372 -15.9942 46.3052
LA-N-6 GDSC1 -2.7962 3.5266 -5.4314 27.6352
KP-N-YN GDSC1 -2.5398 9.2698 -8.0688 35.1977
SK-N-BE(2)-M17 GDSC1 -2.404 5.3051 -5.9726 28.4152
SJNB-13 GDSC1 -1.8037 10.4452 -8.0368 32.7977
SK-N-DZ GDSC1 -1.6034 7.6312 -6.4658 27.466
GI-ME-N GDSC1 -0.8364 37.6423 -20.8367 42.7601
SJNB-7 GDSC1 -0.4564 10.2896 -6.8855 25.491
SJNB-17 GDSC1 0.9017 3.0352 -2.6638 0.6171
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -1.6651 12.7663 -9.0828 34.6174
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 824 GDSC1 -10.643 -0.3464 -11.9225 72.0183
HCC1187 GDSC1 -9.4635 -3.8648 -9.719 76.2659
MDA-MB-468 GDSC1 -9.1973 -1.1979 -10.0801 69.251
HCC1599 GDSC1 -8.8821 -7.5676 -8.8821 85.3219
MRK-nu-1 GDSC1 -8.2476 -5.2951 -8.2724 74.5528
CAL-148 GDSC1 -7.8011 -3.9456 -7.9229 68.1099
DU4475 GDSC1 -7.508 -5.3161 -7.5157 68.3074
HCC38 GDSC1 -7.396 -1.6825 -7.9717 61.3889
HCC2157 GDSC1 -7.3482 -0.8335 -8.1839 60.0409
CAMA-1 GDSC1 -6.8823 0.6999 -8.2379 55.9591
AU565 GDSC1 -6.5553 1.7979 -8.3375 53.5493
HCC1806 GDSC1 -6.5207 11.791 -12.9307 51.6329
MFM-223 GDSC1 -6.0565 -2.1206 -6.3887 50.9138
EFM-19 GDSC1 -5.8492 1.4068 -7.4363 49.2116
Hs 578T GDSC1 -5.3954 5.3471 -8.764 47.2386
OCUB-M GDSC1 -4.8899 12.4382 -11.7294 46.6655
HCC70 GDSC1 -4.3205 8.2234 -9.135 43.1185
HCC1954 GDSC1 -4.0073 39.5198 -24.4334 47.5387
MDA-MB-157 GDSC1 -3.8535 6.8391 -8.0258 39.8562
MCF-7 GDSC1 -3.8373 11.1603 -10.1471 42.4759
MDA-MB-453 GDSC1 -3.3513 27.16 -17.6989 45.3389
BT-20 GDSC1 -2.1378 9.5684 -7.8768 33.4536
BT-549 GDSC1 -1.6288 9.3689 -7.3548 30.4622
T-47D GDSC1 -0.9842 9.5107 -6.9079 27.0886
MDA-MB-361 GDSC1 -0.3168 6.5964 -4.9626 16.5
EFM-192A GDSC1 -0.2874 2.4123 -2.9649 3.4839
ZR-75-30 GDSC1 -0.2075 12.8485 -7.9635 28.1631
BT-474 GDSC1 -0.1382 10.7722 -6.8832 24.6119
HCC1395 GDSC1 -0.0349 72.3691 -37.5367 45.518
HCC1500 GDSC1 0.0519 11.1659 -6.9354 24.2912
HCC2218 GDSC1 0.0771 29.1165 -15.839 38.8451
CAL-85-1 GDSC1 0.1077 16.0944 -9.3315 30.6745
HCC1569 GDSC1 0.2191 16.2653 -9.3306 30.4188
HCC1428 GDSC1 0.3464 7.277 -4.8312 13.9978
Evsa-T GDSC1 0.4286 2.134 -2.5213 0.4338
UACC-812 GDSC1 0.5784 10.9441 -6.4429 21.0988
HCC202 GDSC1 0.7049 16.5662 -9.1111 28.8525
UACC-893 GDSC1 0.892 16.6039 -8.9899 28.1631
YMB-1-E GDSC1 0.938 10.3781 -5.9174 18.0012
CAL-120 GDSC1 1.0013 13.6785 -7.4742 23.7594
MDA-MB-415 GDSC1 1.0747 11.3515 -6.2924 19.2844
HCC1937 GDSC1 1.1104 11.6989 -6.4355 19.7812
HDQ-P1 GDSC1 1.2546 12.0152 -6.4886 19.6573
HCC1419 GDSC1 1.2824 14.7511 -7.7962 24.1217
MDA-MB-175-VII GDSC1 1.5721 12.8102 -6.6538 19.5826
CAL-51 GDSC1 1.643 13.8409 -7.1012 21.0638
MDA-MB-436 GDSC1 1.7307 14.961 -7.5816 22.4767
MDA-MB-231 GDSC1 1.9831 14.3544 -7.1157 20.3835
MDA-MB-330 GDSC1 2.0864 13.5455 -6.66 18.4974
BT-483 GDSC1 3.496 17.24 -7.4877 18.6888
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-336MG GDSC1 -8.5111 -3.328 -8.7884 70.8733
YH-13 GDSC1 -8.5081 -6.3937 -8.5102 79.4017
PFSK-1 GDSC1 -8.4846 -6.5335 -8.4857 79.5743
YKG-1 GDSC1 -8.1395 7.9481 -12.6858 57.1938
U-251MG GDSC1 -8.1293 -6.8404 -8.1293 76.7308
MOG-G-CCM GDSC1 -7.8661 -3.5266 -8.0558 67.6444
GaMG GDSC1 -7.7694 -6.8407 -7.7694 72.5159
DK-MG GDSC1 -7.7033 -0.1909 -8.7883 61.2548
D-247MG GDSC1 -7.5459 -1.9737 -8.0533 62.7538
Daoy GDSC1 -7.4118 -4.3321 -7.4683 65.806
Becker GDSC1 -7.4054 3.6358 -10.0048 56.7668
Hs 683 GDSC1 -7.278 -6.5978 -7.278 66.4017
H4 GDSC1 -6.7139 -1.6894 -7.2256 56.5514
SF126 GDSC1 -6.7107 26.6508 -20.3981 51.2192
SK-MG-1 GDSC1 -6.6375 6.8385 -10.6821 52.6426
MOG-G-UVW GDSC1 -6.5426 0.2567 -7.7046 54.0956
M059J GDSC1 -6.5042 -2.5704 -6.7676 55.4135
GI-1 GDSC1 -6.3 -2.3789 -6.5898 53.3716
D-542MG GDSC1 -6.2638 -2.0084 -6.6447 52.8844
SF539 GDSC1 -6.0609 -1.5719 -6.5484 50.8948
D283 Med GDSC1 -6.0051 -0.9245 -6.6967 50.3433
LN-229 GDSC1 -5.6556 -2.0487 -5.9702 46.7489
KINGS-1 GDSC1 -5.1145 11.8745 -11.6581 47.31
LN-18 GDSC1 -4.8644 -0.6936 -5.5492 39.3344
KALS-1 GDSC1 -4.855 15.1815 -13.052 47.0061
SW1783 GDSC1 -4.4827 0.3788 -5.5789 36.9246
KS-1 [Human Krukenberg tumour] GDSC1 -4.3643 9.4566 -9.7812 43.8712
D-423MG GDSC1 -4.1946 2.1413 -6.0806 36.9724
NMC-G1 GDSC1 -4.0684 5.9126 -7.7701 40.3009
U-118MG GDSC1 -3.8545 4.6452 -6.9524 37.69
AM-38 GDSC1 -3.6959 4.9466 -6.9519 36.9813
GB-1 GDSC1 -3.5294 0.093 -4.4751 25.8804
LNZTA3WT4 GDSC1 -2.8552 2.49 -4.9723 25.549
D-263MG GDSC1 -2.5415 9.2617 -8.0662 35.1976
SNB-75 GDSC1 -2.4755 6.724 -6.7424 31.4709
D-392MG GDSC1 -1.7119 17.7802 -11.6281 38.4216
SW1088 GDSC1 -1.6704 7.794 -6.6018 28.1806
D-566MG GDSC1 -0.8963 15.4141 -9.7813 33.9071
DBTRG-05MG GDSC1 -0.8447 11.0061 -7.5428 28.6835
KNS-42 GDSC1 -0.2162 7.4157 -5.2905 17.9771
CAS-1 GDSC1 -0.1551 13.3071 -8.1507 28.5339
LN-405 GDSC1 -0.0337 6.0747 -4.5121 13.1064
SF268 GDSC1 0.0009 15.4992 -9.1182 30.468
ONS-76 GDSC1 0.0193 14.0949 -8.4077 28.7636
SF295 GDSC1 0.1118 8.0906 -5.3853 17.5653
D-502MG GDSC1 0.4682 9.7554 -5.9427 19.2742
KNS-81-FD GDSC1 0.6687 6.8897 -4.4379 10.9478
42-MG-BA GDSC1 0.7113 5.2597 -3.6668 6.1253
Onda 11 GDSC1 0.8717 10.4472 -5.9963 18.5097
A-172 GDSC1 0.8857 8.3737 -4.996 13.6009
Onda 10 GDSC1 1.1539 13.4992 -7.2778 22.7647
T98G GDSC1 1.4589 11.8409 -6.2658 18.2901
U-87MG ATCC GDSC1 2.2119 13.0355 -6.336 16.9581
8-MG-BA GDSC1 2.6968 17.9002 -8.3328 22.7617
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 -7.0745 -0.9567 -7.846 58.4657
TGBC24TKB GDSC1 -0.3984 8.3559 -5.8858 21.3629
TGBC1TKB GDSC1 0.6327 8.2296 -5.0944 14.7285
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 -8.7749 -2.1441 -9.3489 69.4374
MFE-319 GDSC1 -8.593 -7.1748 -8.593 81.9316
ESS-1 GDSC1 -8.1181 -4.6408 -8.1817 71.9465
MFE-296 GDSC1 -5.9181 1.0486 -7.3584 49.6669
AN3-CA GDSC1 -2.7461 43.2055 -25.2049 46.1704
EN GDSC1 -2.4066 4.154 -5.4004 25.8715
KLE GDSC1 0.1778 15.8453 -9.154 30.1351
MFE-280 GDSC1 0.3191 9.816 -6.0781 20.2499
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
786-O GDSC1 -9.6425 -0.1059 -10.9163 68.8797
SW13 GDSC1 -8.7571 -7.4672 -8.7571 84.0105
KTCTL-140 GDSC1 -7.3447 7.8059 -11.831 54.849
769-P GDSC1 -6.3553 8.1376 -11.0192 51.4324
KTCTL-21 GDSC1 -5.151 8.8148 -10.1962 46.9008
VMRC-RCZ GDSC1 -4.9494 15.1111 -13.1024 47.2632
SN12C GDSC1 -4.3481 4.3059 -7.2559 40.635
KTCTL-26A GDSC1 -4.2127 4.1763 -7.0641 39.6077
RXF 393L GDSC1 -3.8837 13.2868 -11.2439 43.5166
VMRC-RCW GDSC1 -3.7852 4.0836 -6.6143 36.4951
KTCTL-13 GDSC1 -3.5742 4.7987 -6.7669 35.9615
BFTC-909 GDSC1 -2.7977 5.4347 -6.3803 31.5023
NCC021 GDSC1 -0.5479 9.2192 -6.425 24.0499
CAL-54 GDSC1 0.0739 12.8973 -7.7735 26.9127
SW156 GDSC1 0.2455 10.1057 -6.2726 21.2605
HA7-RCC GDSC1 0.4627 8.3401 -5.2623 16.028
KMRC-20 GDSC1 0.8708 18.3024 -9.8439 30.05
BB65-RCC GDSC1 0.9978 15.982 -8.6056 26.9945
A-704 GDSC1 1.1639 13.3522 -7.1992 22.4763
ACHN GDSC1 1.1875 7.7628 -4.5209 10.2988
KTCTL-1M GDSC1 1.2993 13.4133 -7.1335 21.9419
LB1047-RCC GDSC1 1.3245 12.324 -6.5893 19.8911
UO-31 GDSC1 1.3917 12.3269 -6.5445 19.5641
Caki-1 GDSC1 1.4637 10.4799 -5.6152 15.4018
KTCTL-195 GDSC1 1.6711 17.0171 -8.6234 25.5985
LB996-RCC GDSC1 1.8253 17.4745 -8.7362 25.5708
A-498 GDSC1 1.8966 16.9346 -8.4226 24.6
LB2241-RCC GDSC1 2.3292 14.4706 -6.9392 19.0357
RCC10RGB GDSC1 2.5373 20.2754 -9.5936 26.2324
OS-RC-2 GDSC1 2.867 16.7938 -7.6881 20.5097
TK-10 GDSC1 2.9676 16.2424 -7.3598 19.2455
KMRC-1 GDSC1 4.498 21.9996 -9.0846 21.5869
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCT 116 GDSC1 -10.3792 0.1815 -11.8123 70.5062
COLO205 GDSC1 -8.6193 -7.1383 -8.6194 82.0978
COLO 320HSR GDSC1 -7.5714 -5.0241 -7.5897 68.455
SNU-407 GDSC1 -7.3769 -3.0109 -7.6221 63.2479
CCK-81 GDSC1 -7.0765 -4.5019 -7.106 62.875
KM12 GDSC1 -6.8595 0.5016 -8.1368 55.9505
HT-29 GDSC1 -6.3622 -1.6143 -6.8642 53.6055
LoVo GDSC1 -6.2026 3.578 -8.7495 51.2469
HT115 GDSC1 -6.1048 -2.808 -6.2839 51.5118
RKO GDSC1 -6.0803 4.4624 -9.028 50.5645
SNU-175 GDSC1 -5.9602 5.0895 -9.1981 49.9737
HCC2998 GDSC1 -5.9513 2.4312 -7.9837 49.9128
LS513 GDSC1 -5.9277 -0.1565 -6.8901 49.6942
MDST8 GDSC1 -5.526 -1.8668 -5.8787 45.4241
SW48 GDSC1 -5.158 1.1017 -6.5885 43.9104
CaR-1 GDSC1 -5.1293 2.1433 -7.0173 44.3741
NCI-H716 GDSC1 -4.9282 1.3942 -6.4792 42.2555
LS411N GDSC1 -4.3014 71.3678 -40.5967 48.7934
SNU-C2B GDSC1 -3.9243 9.6074 -9.4559 42.0578
SNU-1040 GDSC1 -3.4451 14.7296 -11.5762 42.5808
GP5d GDSC1 -3.1682 7.0807 -7.5264 36.2068
LS180 GDSC1 -2.1205 44.6678 -25.4117 45.5109
HT-55 GDSC1 -0.9314 22.4978 -13.3466 38.538
CL-11 GDSC1 -0.8411 8.6674 -6.3766 24.7225
SNU-C5 GDSC1 -0.7005 14.4036 -9.1214 32.1704
SW837 GDSC1 -0.6227 11.7398 -7.734 28.6188
SW1116 GDSC1 -0.4618 4.9662 -4.2725 12.7617
SNU-81 GDSC1 -0.4069 61.869 -32.5936 45.1205
LS1034 GDSC1 -0.2495 9.5024 -6.34 22.8689
SW620 GDSC1 -0.2477 11.215 -7.1849 25.9331
SW1417 GDSC1 -0.0339 6.6727 -4.8002 14.8053
SNU-C1 GDSC1 0.0179 21.0052 -11.8428 35.0297
T84 GDSC1 0.0227 7.3404 -5.0839 16.2317
SW948 GDSC1 0.2613 2.6213 -2.7758 1.5892
CW-2 GDSC1 0.3128 4.933 -3.7519 7.4631
SNU-61 GDSC1 0.3506 8.4782 -5.4061 17.0439
NCI-H747 GDSC1 0.7614 13.4701 -7.5458 24.5477
SW1463 GDSC1 0.7636 10.8257 -6.2544 19.8747
LS123 GDSC1 0.8761 2.7911 -2.5865 0.4101
SW626 GDSC1 0.9897 12.2242 -6.7741 21.3709
HCT 15 GDSC1 1.002 8.6369 -5.0449 13.593
COLO 678 GDSC1 1.1008 9.1045 -5.2014 14.1833
RCM-1 [Human ESC] GDSC1 1.1026 10.5651 -5.8953 17.5128
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -2.6226 7.8641 -7.4383 33.9959
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HLE GDSC1 -6.3254 -2.8599 -6.5127 53.8312
SNU-475 GDSC1 -5.9158 -1.421 -6.4367 49.5297
SNU-423 GDSC1 -5.8721 5.0938 -9.113 49.5545
JHH-4 GDSC1 -5.3337 -1.1169 -5.9037 43.869
SNU-387 GDSC1 -3.5824 26.5394 -17.587 45.6947
Hep 3B2.1-7 GDSC1 -2.9514 10.0371 -8.8072 37.9497
SNU-398 GDSC1 -2.1917 2.811 -4.545 20.2529
JHH-7 GDSC1 -1.9629 7.0865 -6.4895 28.7739
SK-HEP-1 GDSC1 -1.4631 7.9811 -6.5268 27.2306
JHH-2 GDSC1 -0.4714 6.4058 -4.9809 17.0432
SNU-449 GDSC1 -0.1827 7.7637 -5.4364 18.6244
JHH-6 GDSC1 0.4765 14.0317 -8.0316 26.6623
Huh-7 GDSC1 0.536 12.8493 -7.4059 24.6458
Hep-G2/C3A GDSC1 0.5483 7.693 -4.8949 13.8539
HuH-1 GDSC1 0.7619 8.5549 -5.1634 14.7795
JHH-1 GDSC1 1.0231 19.2967 -10.2205 30.4629
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 171 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1703 GDSC1 -11.6303 -1.1785 -12.7381 75.6086
PC-14 GDSC1 -8.8795 -6.806 -8.8807 83.1873
NCI-H720 GDSC1 -8.7601 -7.567 -8.7601 84.2292
NCI-H524 GDSC1 -8.6861 0.6236 -10.1402 64.5536
LCLC-97TM1 GDSC1 -8.3555 -2.0837 -8.9072 67.4179
NCI-H1770 GDSC1 -8.3317 -7.1216 -8.3317 79.2288
LK-2 GDSC1 -8.3252 -7.5382 -8.3252 79.4473
NCI-H841 GDSC1 -8.0903 0.189 -9.3411 62.6498
NCI-H510A GDSC1 -8.0509 -3.7012 -8.226 69.2105
EPLC-272H GDSC1 -8.0082 -3.144 -8.2798 67.7124
HARA [Human squamous cell lung carcinoma] GDSC1 -7.948 -1.3119 -8.684 64.0319
NCI-H69 GDSC1 -7.942 5.3657 -11.3161 57.811
IST-SL2 GDSC1 -7.8293 -6.1352 -7.8301 72.714
NCI-H661 GDSC1 -7.7783 2.4562 -9.8919 59.0758
NCI-H847 GDSC1 -7.7561 -6.319 -7.7563 72.1058
NCI-H520 GDSC1 -7.7476 9.8103 -13.166 55.4398
COR-L23 GDSC1 -7.694 2.1774 -9.6885 58.9371
NCI-H522 GDSC1 -7.6898 -5.1771 -7.705 69.8142
NCI-H64 GDSC1 -7.5923 -6.1796 -7.5925 70.1345
Calu-6 GDSC1 -7.522 -1.4604 -8.1746 61.8661
SBC-5 GDSC1 -7.4597 -6.4233 -7.4597 68.6452
NCI-H1436 GDSC1 -7.3785 4.3924 -10.3092 56.2709
NCI-H1048 GDSC1 -7.3067 -6.4987 -7.3067 66.758
HCC44 GDSC1 -7.27 -2.1632 -7.7018 61.2034
EMC-BAC-2 GDSC1 -7.1498 -1.8295 -7.6611 59.9323
NCI-H23 GDSC1 -6.8544 -4.2646 -6.8911 60.3226
NCI-H2171 GDSC1 -6.6259 -2.2831 -6.9685 56.3011
NCI-H2369 GDSC1 -6.6014 -2.7372 -6.837 56.4396
Lu-135 GDSC1 -6.5404 0.0822 -7.6362 54.1631
CAL-12T GDSC1 -6.4461 -2.2436 -6.7823 54.6742
NCI-H1581 GDSC1 -6.3377 -3.4907 -6.4236 54.2385
NCI-H2595 GDSC1 -6.1427 2.513 -8.2161 51.0352
CPC-N GDSC1 -6.1136 2.3293 -8.1061 50.8832
NCI-H1155 GDSC1 -6.1037 -1.8344 -6.5182 51.3334
DMS 273 GDSC1 -6.0332 -0.3858 -6.918 50.5488
LC-2/ad GDSC1 -6.0036 1.3303 -7.5652 50.2534
COR-L321 GDSC1 -5.945 3.3583 -8.3898 49.8856
NCI-H1648 GDSC1 -5.8161 1.3688 -7.3858 48.9802
NCI-H526 GDSC1 -5.8041 -1.2858 -6.3583 48.4853
ABC-1 GDSC1 -5.7393 -1.5223 -6.2131 47.7968
SHP-77 GDSC1 -5.7304 -2.865 -5.8683 47.3205
RERF-LC-MS GDSC1 -5.6994 1.4238 -7.2877 48.1726
NCI-H211 GDSC1 -5.6037 16.8703 -14.5643 49.1261
NCI-H2818 GDSC1 -5.5642 -1.2709 -6.1024 46.1334
NCI-H647 GDSC1 -5.3807 4.7131 -8.4511 47.0064
NCI-H2030 GDSC1 -5.2964 -1.5191 -5.7317 43.1487
HCC78 GDSC1 -5.1963 3.4005 -7.6576 45.4821
NCI-H446 GDSC1 -5.1484 -0.1498 -6.0612 42.8254
A-427 GDSC1 -5.0362 1.8316 -6.7834 43.4697
ChaGo-K-1 GDSC1 -5.0311 -0.058 -5.9732 41.7836
NCI-H3122 GDSC1 -5.0279 0.3601 -6.1398 42.1661
NCI-H1355 GDSC1 -5.0279 8.5225 -9.9386 46.3324
NCI-H2722 GDSC1 -4.8241 7.6688 -9.3323 45.1918
NCI-H1781 GDSC1 -4.8108 1.3051 -6.3199 41.1857
NCI-H1876 GDSC1 -4.6837 9.1515 -9.9252 45.0897
EBC-1 GDSC1 -4.6155 2.4233 -6.6286 40.7422
LOU-NH91 GDSC1 -4.5825 3.0149 -6.871 41.0692
UMC-11 GDSC1 -4.5035 8.2602 -9.3219 43.9724
NCI-H1105 GDSC1 -4.3319 4.8832 -7.5181 41.0281
NCI-H1944 GDSC1 -4.2621 5.5919 -7.7952 41.1736
NCI-H82 GDSC1 -4.2279 12.5167 -11.169 44.4486
SBC-3 GDSC1 -4.2101 2.778 -6.3948 37.9814
NCI-H2081 GDSC1 -4.1039 2.9973 -6.3955 37.4346
PaCa-3 GDSC1 -4.0071 5.6461 -7.5829 39.7046
NCI-H1836 GDSC1 -3.8736 4.4224 -6.862 37.5555
NCI-H1304 GDSC1 -3.7256 0.813 -4.9998 29.9417
SBC-1 GDSC1 -3.7002 2.5404 -5.7885 33.3693
NCI-H1975 GDSC1 -3.664 4.507 -6.7073 36.1975
RERF-LC-KJ GDSC1 -3.6433 51.9382 -30.3282 47.7111
Lu-139 GDSC1 -3.5335 54.0215 -31.2764 47.6848
COR-L88 GDSC1 -3.5032 42.0917 -25.2884 47.0458
IST-SL1 GDSC1 -3.4979 2.1245 -5.3952 30.7017
NCI-H1341 GDSC1 -3.1475 5.3922 -6.6707 33.8663
NCI-H1792 GDSC1 -3.1305 5.3106 -6.615 33.6262
NCI-H2141 GDSC1 -3.1121 9.4792 -8.6696 38.2476
NCI-H1437 GDSC1 -3.0771 4.535 -6.1832 31.9606
NCI-H1651 GDSC1 -2.9769 2.6883 -5.1812 27.2
NCI-H810 GDSC1 -2.9417 6.5327 -7.0534 34.151
Lu-99A GDSC1 -2.9282 12.2914 -9.9115 39.4866
NCI-H2066 GDSC1 -2.9083 7.7699 -7.6398 35.5076
NCI-H2029 GDSC1 -2.842 5.9144 -6.658 32.5972
NCI-H1915 GDSC1 -2.5654 23.7706 -15.337 43.0182
NCI-H1694 GDSC1 -2.4433 11.1347 -8.9181 36.5543
HCC15 GDSC1 -2.1372 7.9727 -7.0786 31.3103
NCI-H187 GDSC1 -2.0886 11.8124 -8.9575 35.5774
Lu-65 GDSC1 -2.0382 8.7734 -7.3958 31.8905
DMS 114 GDSC1 -1.9732 7.2118 -6.5607 29.0631
COR-L303 GDSC1 -1.838 15.7634 -10.7241 37.6354
NCI-H1092 GDSC1 -1.7464 14.0679 -9.8005 36.0778
COR-L311 GDSC1 -1.7362 7.7735 -6.6455 28.5534
EKVX GDSC1 -1.549 9.4798 -7.3451 30.1853
COLO 668 GDSC1 -1.4661 9.8115 -7.4434 30.2149
NCI-H2795 GDSC1 -1.394 10.4973 -7.7274 30.786
LXF 289 GDSC1 -1.157 7.9803 -6.2819 25.3194
NCI-H2373 GDSC1 -1.0817 9.6855 -7.072 27.923
Ms-1 GDSC1 -1.0331 9.6574 -7.0195 27.607
DMS 53 GDSC1 -1.0224 6.9841 -5.6809 22.3023
NCI-H2135 GDSC1 -0.9851 8.5743 -6.4425 25.4127
NCI-H460 GDSC1 -0.9615 5.8332 -5.0632 18.9775
NCI-H226 GDSC1 -0.933 12.3502 -8.2823 30.8988
NCI-H650 GDSC1 -0.655 14.3596 -9.0635 31.9367
HCC33 GDSC1 -0.5881 13.5849 -8.6249 30.8045
NCI-H209 GDSC1 -0.5399 14.8325 -9.2082 31.9516
SK-MES-1 GDSC1 -0.5272 9.3211 -6.4598 24.1254
NCI-H2804 GDSC1 -0.5097 8.7282 -6.1531 22.8405
LB647-SCLC GDSC1 -0.4908 17.0186 -10.2585 33.7718
NCI-H2087 GDSC1 -0.4754 11.6444 -7.5722 27.7525
NCI-H2444 GDSC1 -0.4467 9.0854 -6.2821 23.1911
NCI-H146 GDSC1 -0.4326 13.3581 -8.3905 29.8488
NCI-H1623 GDSC1 -0.4193 9.9681 -6.698 24.7163
NCI-H2110 GDSC1 -0.4057 12.5247 -7.9555 28.6545
NCI-H358 GDSC1 -0.3839 13.5888 -8.4673 29.9126
NCI-H196 GDSC1 -0.3547 11.1391 -7.2288 26.3644
NCI-H1299 GDSC1 -0.2803 10.5938 -6.9022 25.0637
NCI-H1666 GDSC1 -0.2144 15.576 -9.3233 31.406
NCI-H322M GDSC1 -0.149 17.8678 -10.4122 33.2663
NCI-H1573 GDSC1 -0.0988 11.5488 -7.2372 25.708
HOP-62 GDSC1 -0.0876 12.7537 -7.8248 27.4691
NCI-H2196 GDSC1 -0.0684 7.3972 -5.1757 16.9686
NCI-H1793 GDSC1 -0.0668 11.1443 -7.0134 24.8751
NCI-H441 GDSC1 -0.0397 26.4472 -14.6008 38.0548
NCI-H2347 GDSC1 -0.0331 6.7629 -4.8433 15.049
NCI-H1734 GDSC1 -0.0061 8.4898 -5.664 19.2447
Lu-134-A GDSC1 0.0407 9.4525 -6.1013 21.0858
IA-LM GDSC1 0.0711 13.4644 -8.0561 27.7147
NCI-H2085 GDSC1 0.115 11.0833 -6.8479 23.8153
NCI-H3255 GDSC1 0.1578 12.6634 -7.5948 26.1716
NCI-H2731 GDSC1 0.2205 9.8758 -6.1781 20.9332
NCI-H513 GDSC1 0.2291 5.1624 -3.9091 8.665
NCI-H727 GDSC1 0.3318 9.4979 -5.914 19.4975
NCI-H1869 GDSC1 0.3627 10.9887 -6.6199 22.3322
LCLC-103H GDSC1 0.3675 12.5152 -7.3657 24.9317
NCI-H345 GDSC1 0.3725 14.3994 -8.2908 27.612
NCI-H1688 GDSC1 0.3738 4.7861 -3.6487 6.6689
SW1271 GDSC1 0.4652 11.3912 -6.7426 22.5334
NCI-H1755 GDSC1 0.4942 8.5129 -5.3238 16.2632
NCI-H2170 GDSC1 0.5827 11.9422 -6.9272 22.9123
NCI-H2803 GDSC1 0.6027 18.6738 -10.231 31.3458
BEN GDSC1 0.6853 20.725 -11.1846 32.7779
NCI-H1563 GDSC1 0.7296 8.6902 -5.2495 15.3029
EMC-BAC-1 GDSC1 0.7711 13.8093 -7.705 25.0148
NCI-H1838 GDSC1 0.8095 8.3622 -5.0404 14.0168
NCI-H2405 GDSC1 0.8298 11.5089 -6.5394 20.8602
NCI-H290 GDSC1 0.8398 11.9385 -6.7412 21.6061
NCI-H2810 GDSC1 0.8416 7.9679 -4.8332 12.8164
NCI-H2291 GDSC1 0.8756 10.0754 -5.8146 17.6873
NCI-H2342 GDSC1 0.9033 3.106 -2.6889 0.6964
NCI-H2009 GDSC1 0.9998 9.6704 -5.5366 16.0869
NCI-H2869 GDSC1 1.1099 10.7888 -5.9977 17.9491
NCI-H838 GDSC1 1.1102 11.6125 -6.3939 19.6147
NCI-H2122 GDSC1 1.1106 8.9743 -5.1337 13.8112
NCI-H2461 GDSC1 1.2073 21.9876 -11.4118 32.1293
NCI-H2023 GDSC1 1.2241 2.8991 -2.4999 0.144
NCI-H292 GDSC1 1.2776 12.0806 -6.5042 19.666
NCI-H2591 GDSC1 1.2786 12.4954 -6.7036 20.4338
Calu-3 GDSC1 1.3613 12.3346 -6.5691 19.7289
NCI-H2228 GDSC1 1.3968 11.2542 -6.027 17.4167
NCI-H596 GDSC1 1.4696 10.8353 -5.7796 16.151
KNS-62 GDSC1 1.5048 12.7263 -6.6593 19.7534
SK-LU-1 GDSC1 1.5135 11.019 -5.8378 16.3176
NCI-H1993 GDSC1 1.5305 15.1617 -7.8196 23.647
NCI-H1435 GDSC1 1.5469 12.8842 -6.7066 19.8393
NCI-H1650 GDSC1 1.5906 13.523 -6.984 20.7641
Lu-165 GDSC1 1.6361 15.2945 -7.8095 23.3883
A-549 GDSC1 1.7644 9.2257 -4.8431 10.892
SW1573 GDSC1 1.7758 13.6246 -6.9063 20.0789
NCI-H2172 GDSC1 1.8731 11.193 -5.6872 14.8542
RERF-LC-Sq1 GDSC1 1.9812 4.0893 -2.6386 0.1944
HCC827 GDSC1 2.1349 15.8139 -7.7137 22.0447
COR-L105 GDSC1 2.5032 14.0467 -6.6243 17.5075
NCI-H1568 GDSC1 3.0165 15.349 -6.9067 17.5655
⏷ Show the Full List of 171 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 -0.3762 15.7402 -9.5314 32.2019
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-410 GDSC1 -8.6154 5.4799 -12.0546 59.8765
KYSE-520 GDSC1 -7.9109 -1.3468 -8.6329 63.8907
TE-10 GDSC1 -7.8019 -0.7326 -8.7098 62.4404
TE-9 GDSC1 -7.3826 -0.9572 -8.1806 60.3894
TE-4 GDSC1 -7.201 -4.1299 -7.2655 63.5842
T.T GDSC1 -7.1595 -1.6012 -7.7374 59.7271
EC-GI-10 GDSC1 -7.0466 0.9557 -8.5126 56.7163
KYSE-450 GDSC1 -6.9977 2.4952 -9.0928 55.557
KYSE-180 GDSC1 -5.8948 14.0908 -13.4648 49.808
KYSE-70 GDSC1 -5.3261 12.1708 -11.9984 48.0339
TE-11 GDSC1 -4.1977 3.8893 -6.912 39.2045
TE-15 GDSC1 -3.6711 4.6093 -6.764 36.3836
KYSE-150 GDSC1 -3.1794 6.1686 -7.084 35.1629
KYSE-140 GDSC1 -1.8296 22.9598 -14.3152 41.0266
TE-8 GDSC1 -1.624 17.5874 -11.459 38.0305
TE-1 GDSC1 -0.7095 11.2927 -7.5794 28.4129
OE21 GDSC1 -0.3711 16.7168 -10.0136 33.0806
COLO 680N GDSC1 -0.1981 18.544 -10.7873 33.9736
KYSE-270 GDSC1 0.4019 7.6638 -4.9789 14.6773
TE-5 GDSC1 0.9135 13.2677 -7.3366 23.5177
OE33 GDSC1 1.3424 9.642 -5.2986 14.133
OE19 GDSC1 3.9441 15.9718 -6.6189 14.8233
KYSE-510 GDSC1 5.6075 19.3791 -7.1827 14.2048
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TOV-112D GDSC1 -9.6145 -8.169 -9.6145 91.815
IGROV-1 GDSC1 -8.2682 8.9726 -13.2872 57.133
OC 314 GDSC1 -7.8742 -6.7136 -7.8742 73.73
OVCAR-8 GDSC1 -7.7584 -1.9266 -8.2982 63.9627
JHOS-2 GDSC1 -7.0895 -0.948 -7.8652 58.5546
A2780 GDSC1 -6.7681 6.3495 -10.5834 53.235
OVCAR-3 GDSC1 -6.1806 -1.0293 -6.8516 51.8595
Caov-3 GDSC1 -5.5834 -1.6146 -6.015 46.1667
OVCAR-5 GDSC1 -4.207 3.1816 -6.5829 38.4633
EFO-21 GDSC1 -3.826 3.8054 -6.5178 36.4146
ES-2 GDSC1 -3.1498 3.8492 -5.9107 31.253
FU-OV-1 GDSC1 -2.8819 4.6802 -6.0801 30.7561
RMG-I GDSC1 -1.4621 16.737 -10.9008 36.9667
SK-OV-3 GDSC1 -1.3902 34.6511 -19.7968 43.1047
OVCAR-4 GDSC1 -1.2184 7.0668 -5.8754 23.812
JHOS-4 GDSC1 -0.6915 6.3614 -5.121 18.461
EFO-27 GDSC1 -0.2116 10.4999 -6.8039 24.5275
DOV13 GDSC1 -0.0535 10.8582 -6.8622 24.3109
OVTOKO GDSC1 0.054 46.5814 -24.5774 42.9609
OVK18 GDSC1 0.5879 13.7297 -7.8004 25.7334
OV-90 GDSC1 0.6136 12.8992 -7.3735 24.3531
OAW42 GDSC1 0.8027 9.4407 -5.5593 16.667
Kuramochi GDSC1 0.8181 12.4204 -6.9914 22.5675
TOV-21G GDSC1 1.0519 12.3211 -6.7774 21.2364
Caov-4 GDSC1 1.0594 3.1652 -2.6503 0.4993
OVKATE GDSC1 1.24 12.0432 -6.5121 19.7835
OAW28 GDSC1 1.3584 3.4508 -2.6402 0.3572
OV56 GDSC1 1.9447 12.0804 -6.0585 16.3554
OVISE GDSC1 3.8227 21.2701 -9.1856 22.9706
TYK-nu GDSC1 3.9995 20.4396 -8.6722 21.3369
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-4 GDSC1 -7.4853 3.2584 -9.9245 57.3128
HuP-T4 GDSC1 -6.3368 -2.1267 -6.6931 53.6105
Panc 03.27 GDSC1 -6.2655 1.4421 -7.8858 51.9304
HuP-T3 GDSC1 -4.6622 3.7 -7.2711 42.2054
Panc 10.05 GDSC1 -4.5196 2.2594 -6.4574 39.8127
QGP-1 GDSC1 -4.3535 135.1424 -72.5197 49.3654
MZ-PC-1 GDSC1 -4.1914 0.1001 -5.1576 33.3606
KP-3 GDSC1 -4.0143 20.7791 -15.0874 45.7314
KP-1N GDSC1 -3.4408 2.7517 -5.6437 31.5126
SUIT-2 GDSC1 -2.6981 3.9573 -5.5577 27.8072
Capan-1 GDSC1 -2.6349 5.3124 -6.1765 30.1176
PSN1 GDSC1 -2.1627 12.02 -9.1234 36.089
PaTu 8902 GDSC1 -1.2929 9.2684 -7.0324 28.4336
Panc 08.13 GDSC1 -1.1983 7.543 -6.0967 24.6968
SW1990 GDSC1 -0.9042 16.5746 -10.3668 34.8959
BxPC-3 GDSC1 -0.442 18.032 -10.7249 34.4058
Panc 02.03 GDSC1 -0.1944 12.5624 -7.8116 27.7055
AsPC-1 GDSC1 0.0224 15.1985 -8.9525 30.052
HPAC GDSC1 0.1809 9.665 -6.1036 20.7215
SU.86.86 GDSC1 0.3239 17.3787 -9.8024 31.1374
PaTu 8988t GDSC1 0.6678 10.0128 -5.9276 18.7055
Capan-2 GDSC1 0.6712 17.964 -9.8274 30.4377
CFPAC-1 GDSC1 1.0796 15.9178 -8.514 26.5794
PL4 GDSC1 1.1411 10.8075 -5.9854 17.8223
DAN-G GDSC1 1.1711 14.1723 -7.5935 23.748
Hs 766T GDSC1 1.4063 11.6802 -6.2243 18.2359
YAPC GDSC1 2.0066 12.5743 -6.2516 17.0393
MIA PaCa-2 GDSC1 2.1476 19.8606 -9.6698 27.1356
HPAF-II GDSC1 2.5543 14.0546 -6.595 17.2927
Panc 04.03 GDSC1 3.7625 21.3501 -9.2645 23.2684
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1 -2.8833 5.804 -6.6395 32.7016
NCI-H2452 GDSC1 -1.4392 9.9514 -7.4915 30.2705
MSTO-211H GDSC1 -1.1598 17.3557 -10.9633 36.3521
IST-Mes1 GDSC1 0.6229 10.1832 -6.0415 19.3184
NCI-H28 GDSC1 0.92 9.7552 -5.6307 16.7258
NCI-H2052 GDSC1 4.5519 21.2671 -8.7032 20.4968
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 -6.3839 -2.6836 -6.6121 54.3304
PC-3 GDSC1 -5.6569 2.604 -7.7594 48.121
22Rv1 GDSC1 -5.5647 1.0068 -6.9712 47.0747
DU145 GDSC1 -4.0878 1.4943 -5.6746 34.9719
LNCaP clone FGC GDSC1 -0.4039 17.6681 -10.5134 33.992
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 -1.8236 9.61 -7.6356 31.8503
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CP50-MEL-B GDSC1 -9.0956 7.3085 -13.3569 60.0994
A-431 GDSC1 -8.8733 -7.7756 -8.8733 85.679
SK-MEL-2 GDSC1 -7.5387 0.8871 -9.0098 59.3148
COLO 800 GDSC1 -6.4009 0.3678 -7.5961 53.1029
M14 GDSC1 -5.5393 1.842 -7.3027 47.1573
SK-MEL-24 GDSC1 -5.3811 3.6479 -7.9557 46.7038
WM115 GDSC1 -4.4277 8.7826 -9.5081 43.8605
IGR-37 GDSC1 -4.2801 3.1656 -6.6462 38.9946
G-361 GDSC1 -3.7448 10.3702 -9.6726 41.7006
Hs 938.T GDSC1 -3.5448 36.9231 -22.7412 46.7312
COLO 783 GDSC1 -3.492 20.3403 -14.4149 44.3854
A-388 GDSC1 -3.358 10.1197 -9.2046 39.8699
DJM-1 GDSC1 -3.3164 8.1287 -8.1785 38.0962
WM278 GDSC1 -3.0623 7.0958 -7.44 35.6045
RPMI-7951 GDSC1 -2.9238 5.9087 -6.7274 33.1353
MeWo GDSC1 -2.8843 24.4347 -15.939 43.8873
Mel JuSo GDSC1 -2.812 20.7088 -14.0157 42.7695
A2058 GDSC1 -1.3651 12.4401 -8.6745 32.9729
HT-144 GDSC1 -0.9723 39.1599 -21.7066 43.2339
IGR-1 GDSC1 -0.5818 25.8521 -14.7389 39.0905
A-375 GDSC1 -0.3823 11.3988 -7.3787 26.9142
LB2518-MEL GDSC1 -0.3343 44.0362 -23.6217 43.0952
LB373-MEL-D GDSC1 -0.1957 15.0864 -9.0654 30.8191
MZ-MEL-7 GDSC1 -0.0924 10.6886 -6.8076 24.2191
WM1552C GDSC1 -0.0251 19.4069 -11.081 34.0537
WT2-iPS GDSC1 -0.0244 16.3133 -9.5421 31.4061
LOX-IMVI GDSC1 0.0845 9.0898 -5.892 20.0513
COLO 679 GDSC1 0.3983 12.5287 -7.3496 24.8035
SK-MEL-30 GDSC1 0.4514 12.7878 -7.4378 24.9546
COLO 829 GDSC1 0.4523 25.1972 -13.5885 36.2593
MMAc-SF GDSC1 0.5307 11.7975 -6.894 22.9223
CP66-MEL GDSC1 0.56 15.7592 -8.8214 28.5044
SK-MEL-3 GDSC1 0.6663 10.0385 -5.9411 18.7691
A101D GDSC1 0.7061 16.6038 -9.1288 28.8898
G-mel GDSC1 0.9347 3.4676 -2.8105 1.1183
SH-4 GDSC1 0.9607 12.3729 -6.8668 21.7806
WM793 GDSC1 1.0107 20.0616 -10.6079 31.188
UACC-62 GDSC1 1.0986 7.4083 -4.412 9.8589
IST-MEL1 GDSC1 1.2487 12.5592 -6.7552 20.6965
MZ-MEL-2 GDSC1 1.2751 15.951 -8.3878 25.8193
451Lu GDSC1 1.2838 11.019 -5.9905 17.5145
GAK GDSC1 1.3488 12.177 -6.5018 19.4936
SK-MEL-1 GDSC1 1.4185 13.4062 -7.0468 21.3701
HMV-II GDSC1 1.5351 11.2765 -5.9459 16.7515
SK-MEL-28 GDSC1 1.9692 20.1874 -9.9586 28.0881
UACC-257 GDSC1 2.3385 14.2615 -6.8336 18.6299
Mel Ho GDSC1 2.4312 14.3114 -6.7963 18.3037
CHL-1 GDSC1 2.7508 15.154 -6.9863 18.365
RVH-421 GDSC1 2.9147 15.4322 -7.0113 18.1376
IPC-298 GDSC1 3.0971 14.9975 -6.6909 16.6117
SK-MEL-5 GDSC1 3.1305 18.2424 -8.2032 21.5723
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -7.9904 -6.2007 -7.9914 74.4505
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 633.T GDSC1 -10.3152 0.1095 -11.7185 70.4523
G-401 GDSC1 -9.0855 6.0745 -12.7978 60.8282
SK-UT-1 GDSC1 -9.004 1.0731 -10.6478 65.1267
KYM-1 GDSC1 -8.0885 -4.3246 -8.1819 70.9511
SW872 GDSC1 -7.5758 -3.8175 -7.7 66.1911
EW-8 GDSC1 -7.5411 -6.5237 -7.5411 69.6603
SW982 GDSC1 -7.2275 1.7145 -9.0083 57.1364
SK-LMS-1 GDSC1 -6.966 -5.2319 -6.9688 62.3016
Rh41 GDSC1 -6.8915 -0.0397 -7.9676 56.5149
GCT GDSC1 -6.8431 2.2216 -8.816 54.9208
HT-1080 GDSC1 -6.4284 -0.5513 -7.2842 53.6595
TE 441.T GDSC1 -6.2538 0.6602 -7.5547 52.0222
RD GDSC1 -5.8371 -1.3489 -6.3739 48.7897
Rh30 GDSC1 -5.6651 4.3349 -8.5556 48.4476
G-402 GDSC1 -4.2213 72.0991 -40.8942 48.7461
RKN GDSC1 -3.0146 4.6508 -6.1842 31.6984
SW684 GDSC1 -1.6926 11.1188 -8.2819 33.0376
MES-SA GDSC1 -0.5623 73.0227 -38.297 45.9798
Rh18 GDSC1 0.4981 2.7478 -2.7206 1.104
VA-ES-BJ GDSC1 1.3069 23.3467 -12.0088 32.8282
A-204 GDSC1 1.8409 16.2375 -8.1232 23.8799
MFH-ino GDSC1 2.0415 16.8647 -8.2866 23.929
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 GDSC1 -12.1592 10.0803 -17.7103 64.6637
HSC-39 GDSC1 -8.468 -6.5258 -8.4691 79.4214
IM95 GDSC1 -8.3451 4.4764 -11.3386 59.6929
SNU-16 GDSC1 -8.0941 -5.9438 -8.0979 74.9425
RF-48 GDSC1 -8.0111 -3.029 -8.3063 67.487
SNU-5 GDSC1 -7.4646 -2.3059 -7.8774 62.7383
KATO III GDSC1 -6.4883 0.4379 -7.7163 53.6589
MKN1 GDSC1 -6.0947 7.7934 -10.6034 50.4936
OCUM-1 GDSC1 -5.3486 10.3789 -11.1429 47.9001
23132/87 GDSC1 -5.3264 1.5678 -6.964 45.5096
NUGC-3 GDSC1 -3.9203 63.8537 -36.5181 48.345
RERF-GC-1B GDSC1 -3.8878 5.4457 -7.374 38.781
SCH GDSC1 -3.6198 14.732 -11.7301 43.1516
NCI-N87 GDSC1 -3.6024 8.7891 -8.7614 40.0696
MKN7 GDSC1 -3.1854 8.6422 -8.3176 37.8852
Hs 746.T GDSC1 -0.5717 16.2987 -9.9638 33.4557
GCIY GDSC1 -0.3699 8.9366 -6.1509 22.4308
NUGC-4 GDSC1 0.0638 15.765 -9.2017 30.5013
AGS GDSC1 0.5153 33.6706 -17.7608 39.4831
Fu97 GDSC1 0.8112 2.6677 -2.5671 0.3876
SNU-1 GDSC1 0.8743 2.4538 -2.4709 0.1712
MKN45 GDSC1 0.9608 24.4301 -12.8111 34.4965
ECC10 GDSC1 0.9803 10.7979 -6.0905 18.6586
MKN28 GDSC1 1.2664 10.7682 -5.8823 17.0744
TGBC11TKB GDSC1 1.415 17.5634 -9.0762 27.2509
SNG-M GDSC1 -8.5519 -7.5311 -8.5519 82.0555
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMH-2 GDSC1 -8.68 -7.3721 -8.68 83.1156
IHH-4 GDSC1 -8.6229 3.8627 -11.3635 61.0522
TT2609-C02 GDSC1 -7.6346 12.0806 -14.1337 54.5617
TT GDSC1 -6.2586 4.161 -9.0694 51.458
K5 GDSC1 -4.8614 3.0717 -7.1729 43.0902
8505C GDSC1 -4.5405 3.9099 -7.2522 41.5637
8305C GDSC1 -3.5711 12.0863 -10.3708 41.8833
CAL-62 GDSC1 -3.1443 4.9323 -6.4403 33.1282
ASH-3 GDSC1 -1.9606 3.5487 -4.7187 20.4311
WRO GDSC1 -1.9076 6.8514 -6.3259 27.9781
HTC-C3 GDSC1 -0.6611 8.5321 -6.171 23.358
ML-1 [Human leukemia] GDSC1 0.736 9.2395 -5.5081 16.5811
BHT-101 GDSC1 0.8895 11.0948 -6.2968 19.7439
B-CPAP GDSC1 1.371 8.4832 -4.7406 11.1419
CGTH-W-1 GDSC1 1.8196 17.0945 -8.5551 25.1125
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-38 GDSC1 -12.6822 4.0246 -15.7071 70.3629
BICR 22 GDSC1 -9.4099 -8.6812 -9.4099 92.3405
NCI-H3118 GDSC1 -8.4859 -3.4644 -8.7353 71.0791
BB30-HNC GDSC1 -8.1807 -5.9093 -8.1858 75.6029
BICR 10 GDSC1 -8.0753 -1.322 -8.8196 64.698
PCI-06A GDSC1 -8.0012 -6.2505 -8.002 74.6355
PCI-04B GDSC1 -7.9514 -4.2606 -8.044 69.875
LB771-HNC GDSC1 -7.9328 7.8556 -12.4372 56.6337
HO-1-N-1 GDSC1 -7.9231 -1.4271 -8.6219 64.0796
BICR 78 GDSC1 -7.8156 -1.3214 -8.5368 63.3423
CAL-33 GDSC1 -7.7435 -3.0408 -8.0136 65.8535
JHU-011 GDSC1 -7.691 -6.0532 -7.6916 71.1386
CAL-27 GDSC1 -7.4996 -4.2453 -7.5686 66.4015
Ca9-22 GDSC1 -7.3925 -5.7758 -7.3934 67.5653
SKN-3 GDSC1 -7.0513 5.8313 -10.6267 54.4455
PCI-15A GDSC1 -6.6822 2.7943 -8.8941 53.8714
OSC-19 GDSC1 -5.9152 -0.9695 -6.584 49.5509
OSC-20 GDSC1 -5.6979 32.6865 -22.4926 49.6183
SCC-9 GDSC1 -5.3221 765.2873 -388.3928 49.9541
SAT [Human HNSCC] GDSC1 -5.0538 8.3865 -9.8968 46.4062
SCC-25 GDSC1 -5.0177 7.9992 -9.6748 46.1519
KOSC-2 GDSC1 -3.5791 21.465 -15.0514 44.8365
BHY GDSC1 -2.9209 9.887 -8.7058 37.6796
DOK GDSC1 -2.143 15.0503 -10.6219 38.2639
PCI-30 GDSC1 -1.0839 17.682 -11.0648 36.3169
Detroit 562 GDSC1 -0.5816 14.4997 -9.0753 31.7793
SAS GDSC1 0.0987 11.5754 -7.1023 24.7447
BICR 31 GDSC1 0.1542 39.3379 -20.8786 41.5382
PE/CA-PJ15 GDSC1 0.3595 28.4387 -15.2763 37.965
SCC-15 GDSC1 0.5305 11.2729 -6.6376 21.9755
JHU-022 GDSC1 0.7506 25.484 -13.4978 35.6489
HO-1-u-1 GDSC1 1.1395 2.9361 -2.5417 0.2267
KON GDSC1 1.4258 12.8032 -6.7505 20.2759
HSC-3 GDSC1 1.7066 12.8648 -6.5889 19.0358
HSC-2 GDSC1 1.7536 12.9018 -6.575 18.8795
BB49-HNC GDSC1 1.921 15.6287 -7.7722 22.6698
HSC-4 GDSC1 3.8795 18.3418 -7.7595 18.8807
FaDu GDSC1 4.9701 19.8569 -7.7814 17.1333
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-112 GDSC1 -8.4908 -6.9951 -8.4909 80.6402
5637 GDSC1 -7.3758 -6.3 -7.3758 67.5947
UM-UC-3 GDSC1 -6.9402 -2.879 -7.1753 59.5884
SW1710 GDSC1 -5.1603 -1.77 -5.5074 41.3844
BFTC-905 GDSC1 -4.6687 8.2706 -9.4804 44.7151
639V GDSC1 -4.0303 0.1204 -4.9997 31.6352
SW780 GDSC1 -3.7442 2.1645 -5.6513 33.0496
CAL-29 GDSC1 -2.9161 7.9378 -7.7303 35.7424
647V GDSC1 -2.8155 2.2595 -4.8225 24.5312
RT-4 GDSC1 -2.1806 24.157 -15.2066 42.2406
T24 GDSC1 -1.1143 6.8507 -5.6861 22.6181
KU-19-19 GDSC1 0.0949 5.8509 -4.319 11.5924
HT-1376 GDSC1 0.6611 10.6284 -6.2307 20.029
HT-1197 GDSC1 0.8937 5.0155 -3.46 4.5484
J82 GDSC1 3.3367 14.8591 -6.4772 15.3472
TCCSUP GDSC1 3.8662 19.914 -8.5105 21.1235
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NEC8 GDSC1 -10.024 1.7932 -12.0112 67.3254
SW954 GDSC1 -8.4266 -7.1629 -8.4266 80.2816
TC-YIK GDSC1 -8.2246 -6.8834 -8.2247 77.8078
JAR GDSC1 -7.6132 -5.0742 -7.6305 68.9283
PWR-1E GDSC1 -7.4494 -5.1787 -7.4596 67.5241
MS751 GDSC1 -7.1431 -4.8458 -7.1578 63.9584
SiSo GDSC1 -6.9203 -2.5084 -7.2349 58.9954
C-33 A GDSC1 -6.8255 -2.1669 -7.2158 57.8682
CAL-39 GDSC1 -6.0702 1.7139 -7.7965 50.6673
KGN GDSC1 -6.0059 2.0405 -7.8698 50.2494
HeLa GDSC1 -5.6805 -2.3906 -5.9121 46.8972
Ca Ski GDSC1 -5.4079 0.2576 -6.4983 45.4762
UWB1.289 GDSC1 -5.3875 0.4364 -6.5492 45.4002
NCC-IT GDSC1 -5.2819 15.2694 -13.4821 48.2003
LB831-BLC GDSC1 -5.1262 2.1821 -7.0316 44.3751
BPH-1 GDSC1 -4.5958 3.5341 -7.1279 41.6229
C-4-I GDSC1 -4.172 2.6938 -6.3178 37.5653
PA-1 GDSC1 -4.001 4.9514 -7.2387 38.9968
HEY GDSC1 -3.5324 2.3464 -5.5348 31.4949
DoTc2 4510 GDSC1 -3.2313 8.1088 -8.093 37.6294
ME-180 GDSC1 -3.1398 4.7072 -6.325 32.7245
ACC-OV7 GDSC1 -1.6408 10.4787 -7.9193 32.019
JEG-3 GDSC1 -0.5766 17.4678 -10.5506 34.435
SKG-IIIa GDSC1 -0.2544 41.2091 -22.1441 42.5182
SW962 GDSC1 -0.2452 14.5778 -8.8511 30.4657
OVCA420 GDSC1 -0.2408 8.0583 -5.623 19.6993
OV17R GDSC1 0.0544 6.7468 -4.7751 14.4274
OVMIU GDSC1 0.1168 15.9042 -9.2301 30.4394
DSH1 GDSC1 0.3658 8.4672 -5.3902 16.9253
HT-3 GDSC1 0.4501 12.3935 -7.2451 24.3329
NT2-D1 GDSC1 0.5339 6.4177 -4.3025 10.4425
OMC-1 [Human cervical carcinoma] GDSC1 0.5424 9.572 -5.8017 18.4501
OVCA433 GDSC1 0.5843 11.2175 -6.572 21.5898
SW756 GDSC1 0.7211 11.1446 -6.4392 20.7302
PEO1 GDSC1 0.7583 7.4419 -4.6395 11.918
JHOS-3 GDSC1 1.0144 10.7113 -6.0254 18.2955
SiHa GDSC1 1.1728 9.9076 -5.5347 15.675
SKN GDSC1 1.3939 12.1346 -6.4506 19.1882
HEC-1 GDSC1 2.4196 17.1348 -8.1545 22.794
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT01989325) A Study of Filanesib (ARRY-520) and Carfilzomib in Patients With Advanced Multiple Myeloma. U.S. National Institutes of Health.
3 Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. Leukemia. 2009 Oct;23(10):1755-62.