Details of the Drug

General Information of Drug (ID: DMTUKZH)

• Drug Name: Deferoxamine Mesylate
• Synonyms: Desferal

Indication

Disease Entry	ICD 11	Status	REF
Acute iron or aluminum toxicity	FB83.20	Approved	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 4:
  Molecular Weight; 656.8
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 23
  Hydrogen Bond Donor Count; 7
  Hydrogen Bond Acceptor Count; 12
• Chemical Identifiers:
  Formula: C26H52N6O11S
  IUPAC Name: N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide;methanesulfonic acid
  Canonical SMILES: CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O.CS(=O)(=O)O
  InChI: InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
  InChIKey: IDDIJAWJANBQLJ-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 62881
  ChEBI ID: CHEMBL31460
  CAS Number: 138-14-7
  TTD ID: D0FJ8A
  ACDINA ID: D00991
• Drug ADMET Endpoint Profile (DAE)NEW: Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Iron (Fe)	TTUDR0C	NOUNIPROTAC	Modulator	[2]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Water	E00035	962	Solvent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Deferoxamine Mesylate 500mg lyophilized powder	500mg	Lyophilized Powder	Intravenous; Subcutaneous; Intramuscular

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References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.