Details of the Drug

General Information of Drug (ID: DMU0746)

Drug Name
Rac-2-amino-5-cyclohexylpentanoic acid
Synonyms
5-Cyclohexylnorvaline; CHEMBL380671; 5428-12-6; NSC12805; rac-2-amino-5-cyclohexylpentanoic acid; AC1Q5S7K; AC1L5D9O; SCHEMBL5843561; 2-amino-5-cyclohexyl-valeric acid; 2-amino-5-cyclohexylpentanoic acid; NSC-12805; BDBM50179718
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 199.29
Logarithm of the Partition Coefficient (xlogp) 0.7
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C11H21NO2
IUPAC Name
2-amino-5-cyclohexylpentanoic acid
Canonical SMILES
C1CCC(CC1)CCCC(C(=O)O)N
InChI
InChI=1S/C11H21NO2/c12-10(11(13)14)8-4-7-9-5-2-1-3-6-9/h9-10H,1-8,12H2,(H,13,14)
InChIKey
LGIVZSMPEFXNLH-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
224404
CAS Number
5428-12-6
TTD ID
D06EUM

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) TTFK1JQ CA2D1_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 9.36E-01 -0.03 -0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 2.81E-05 -0.15 -0.68
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.