Details of the Drug

General Information of Drug (ID: DMU86XT)

Drug Name
YM-201636
Synonyms
371942-69-7; YM201636; YM 201636; 6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide; 3-pyridinecarboxamide, 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-; 6-amino-n-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide; 6-amino-N-[3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenyl]-3-pyridinecarboxamide; PubChem22459; cc-386; MLS006010997; SCHEMBL258416; CHEMBL2178735; CHEBI:91382; AOB1919; DTXSID90433303; EX-A037; QCR-257; BCPP000006; HMS3229J15; HMS3295C07; HMS3654F03; AMY23718; BCP01972; ABP000099; MFCD16038303; s1219; ZINC34048998; AKOS027250783; CCG-264866; CS-0592; NCGC00346683-01; NCGC00346683-09; 6-amino-N-[3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenyl]pyridine-3-carboxamide; AK175782; AS-16693; HY-13228; SMR004702795; AB0035851; FT-0756177; SW218129-2; Y0272; A19418; W-5608; 942Y697; J-518249; BRD-K48488978-001-01-2; Q27163245; YM-201636,CAS:371942-69-7; 6-Amino-N-[3-(6-morpholin-4-yl-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl)phenyl]pyridine-3-carboxamide; 6-Amino-N-{3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl}pyridine-3-carboxamide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Preclinical [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 467.5
Logarithm of the Partition Coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 9
Chemical Identifiers
Formula
C25H21N7O3
IUPAC Name
6-amino-N-[3-(6-morpholin-4-yl-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl)phenyl]pyridine-3-carboxamide
Canonical SMILES
C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)NC(=O)C6=CN=C(C=C6)N
InChI
InChI=1S/C25H21N7O3/c26-19-7-6-16(14-28-19)24(33)29-17-4-1-3-15(13-17)22-30-20-18-5-2-8-27-25(18)35-21(20)23(31-22)32-9-11-34-12-10-32/h1-8,13-14H,9-12H2,(H2,26,28)(H,29,33)
InChIKey
YBPIBGNBHHGLEB-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9956222
ChEBI ID
CHEBI:91382
CAS Number
371942-69-7
TTD ID
DPN2R7

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphatidylinositol-3-phosphate 5-kinase (PIP5K3) TTA4M1N FYV1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 1.7537 4.057 0.9631 13.3706
ES7 GDSC1 -2.2751 2.5203 -2.7438 55.695
ES1 GDSC1 -0.555 3.7863 -1.3004 39.6729
EW-7 GDSC1 -0.5418 3.2887 -1.1025 38.8721
MHH-ES-1 GDSC1 -0.3645 4.0331 -1.1942 37.999
ES8 GDSC1 -0.1419 2.5747 -0.4327 32.9702
ES5 GDSC1 -0.0903 4.004 -0.8925 34.9764
EW-1 GDSC1 0.0297 3.6277 -0.6157 32.8787
TC-71 GDSC1 0.1337 3.7942 -0.5714 32.0107
EW-3 GDSC1 0.1411 3.6793 -0.5177 31.6771
NOS-1 [Human HNSCC] GDSC1 0.3896 4.591 -0.642 30.8911
ES4 GDSC1 0.4439 5.4722 -0.9852 32.2736
EW-13 GDSC1 0.6332 3.8907 -0.0871 26.3135
EW-18 GDSC1 0.7242 4.0912 -0.0794 25.7747
SK-ES-1 GDSC1 0.7915 3.5856 0.2063 23.5317
EW-16 GDSC1 1.5518 5.3581 0.1416 20.2771
SK-PN-DW GDSC1 1.5748 4.1016 0.7698 15.6341
EW-11 GDSC1 1.8553 6.9751 -0.383 22.3443
ES6 GDSC1 1.8889 3.4817 1.3686 9.663
H-EMC-SS GDSC1 2.0901 5.5686 0.5231 15.3006
CADO-ES1 GDSC1 2.128 4.6705 1.0037 11.5044
CHSA8926 GDSC1 2.4435 3.7727 1.7193 4.715
CAL-78 GDSC1 2.6481 4.0519 1.7375 3.9178
A-673 GDSC1 2.8077 4.8635 1.456 5.6202
HuO9 GDSC1 2.8555 5.2051 1.3233 6.5008
SJSA-1 GDSC1 3.0076 5.4177 1.3284 6.0226
G-292 clone A141B1 GDSC1 3.065 7.1226 0.5348 11.7871
HOS GDSC1 3.1333 5.1559 1.5389 4.1138
HuO-3N1 GDSC1 3.2179 5.5879 1.3897 5.0039
CHSA0108 GDSC1 3.603 5.7839 1.536 3.1076
NY GDSC1 3.6908 5.9896 1.4942 3.2187
EW-24 GDSC1 3.8308 7.5166 0.877 7.2074
CHSA0011 GDSC1 4.0089 6.714 1.3517 3.565
MG-63 GDSC1 4.1598 5.7027 1.843 0.6482
SaOS-2 GDSC1 4.4436 5.9267 1.8731 0.3744
CAL-72 GDSC1 5.056 6.6048 1.8599 0.1892
U2OS GDSC1 5.155 7.0748 1.7329 0.4349
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 144 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 1.6692 4.3878 0.7234 15.5596
ST486 GDSC1 -1.4837 3.6839 -2.2595 48.6162
P30/OHK GDSC1 -0.9975 2.5584 -1.361 43.2054
NU-DUL-1 GDSC1 -0.9843 1.9335 -1.1832 42.5558
SU-DHL-5 GDSC1 -0.9204 2.3245 -1.2111 42.1242
MHH-PREB-1 GDSC1 -0.8963 1.9377 -1.0885 41.5
Farage GDSC1 -0.842 4.8267 -2.0205 43.5155
Ku812 GDSC1 -0.8141 1.9698 -1.0064 40.5291
NALM-6 GDSC1 -0.7192 2.3213 -0.9906 39.7354
SIG-M5 GDSC1 -0.4697 1.7788 -0.5915 36.0253
DND-41 GDSC1 -0.3936 3.3192 -0.9536 37.2361
KMS-11 GDSC1 -0.3927 3.3912 -0.9788 37.3369
CESS GDSC1 -0.2073 3.0174 -0.6464 34.5458
HH [Human lymphoma] GDSC1 -0.1743 5.4563 -1.6011 38.1918
ALL-SIL GDSC1 -0.1256 3.0176 -0.5579 33.5531
ALL-PO GDSC1 -0.1185 3.4657 -0.7119 34.2991
SU-DHL-16 GDSC1 -0.0249 1.1649 -0.038 29.8452
MLMA GDSC1 -0.0183 4.2113 -0.9019 34.5699
CA46 GDSC1 0.0027 2.4703 -0.2443 30.9545
SU-DHL-6 GDSC1 0.047 2.1311 -0.1062 29.8309
GDM-1 GDSC1 0.1098 4.3048 -0.8073 33.3487
RS4;11 GDSC1 0.1624 4.9738 -1.0434 34.1169
NKM-1 GDSC1 0.222 4.5224 -0.7843 32.5737
DB GDSC1 0.2608 2.9519 -0.1171 28.6128
MY-M12 GDSC1 0.2649 5.7862 -1.3082 34.6291
Karpas-620 GDSC1 0.2687 3.2261 -0.2072 29.1222
KMOE-2 GDSC1 0.2847 2.9206 -0.0805 28.2418
697 GDSC1 0.3055 3.7682 -0.3794 29.9284
GR-ST GDSC1 0.374 3.871 -0.3496 29.3604
RPMI-8402 GDSC1 0.3805 4.2699 -0.5114 30.2406
BE-13 GDSC1 0.4264 4.1735 -0.4225 29.4831
BL-41 GDSC1 0.4291 1.788 0.3766 24.4227
LC4-1 GDSC1 0.4735 3.6049 -0.1361 27.5051
OCI-Ly19 GDSC1 0.4742 2.8522 0.1482 25.6675
P32/ISH GDSC1 0.5196 3.809 -0.1714 27.467
SU-DHL-10 GDSC1 0.5684 1.6103 0.5471 22.4813
CTV-1 GDSC1 0.64 3.5636 0.0563 25.3494
RPMI-8866 GDSC1 0.6483 3.8267 -0.0443 25.9584
SUP-HD1 GDSC1 0.6518 2.9215 0.3161 23.5431
ML-2 GDSC1 0.6519 3.3793 0.143 24.7102
U-698-M GDSC1 0.6705 3.1073 0.2681 23.7661
Loucy GDSC1 0.7596 3.3955 0.2506 23.4011
RL GDSC1 0.7957 5.1576 -0.4902 27.8723
EB2 GDSC1 0.8513 2.867 0.5506 20.8336
AMO1 GDSC1 0.8563 3.5372 0.2943 22.5873
EoL-1 GDSC1 0.9732 4.0572 0.1904 22.6961
NB4 GDSC1 0.9849 4.4931 0.005 23.8785
PF-382 GDSC1 1.0076 4.6141 -0.0281 23.9808
HT GDSC1 1.0511 2.9787 0.724 18.542
MC116 GDSC1 1.0551 2.0967 0.9978 16.6317
PL-21 GDSC1 1.0561 5.6386 -0.4635 26.4122
QIMR-WIL GDSC1 1.0627 4.7475 -0.0355 23.7557
Daudi GDSC1 1.0937 3.6842 0.4782 20.0752
JSC-1 GDSC1 1.0997 4.1173 0.2916 21.3623
SU-DHL-8 GDSC1 1.108 6.4843 -0.8222 28.1072
SR GDSC1 1.1123 2.2817 1.0183 16.1612
YT GDSC1 1.1426 3.8925 0.4363 20.1297
KOPN-8 GDSC1 1.1642 3.3701 0.686 18.2265
Namalwa GDSC1 1.1892 2.9157 0.8957 16.5899
WSU-NHL GDSC1 1.1912 3.3942 0.704 17.9594
KE-37 GDSC1 1.2035 4.3416 0.2926 20.8467
SUP-B15 GDSC1 1.2249 3.5881 0.6551 18.1453
OCI-M1 GDSC1 1.2989 6.1899 -0.5001 25.4678
KG-1 GDSC1 1.3003 4.6504 0.243 20.7301
SU-DHL-4 GDSC1 1.302 4.6269 0.2558 20.633
CCRF-CEM GDSC1 1.3151 4.6154 0.274 20.4439
Karpas-299 GDSC1 1.3386 3.0733 0.992 15.1194
TUR GDSC1 1.3391 3.4205 0.8457 16.1864
Reh GDSC1 1.345 4.5741 0.3226 19.9613
SK-MM-2 GDSC1 1.3571 5.5422 -0.1305 22.9614
Karpas-45 GDSC1 1.3824 4.5436 0.3733 19.4268
OPM-2 GDSC1 1.3916 5.0147 0.1571 20.8971
WIL2 NS GDSC1 1.4031 3.2528 0.9842 14.8507
MOLM-13 GDSC1 1.4243 5.485 -0.0395 22.0645
HAL-01 GDSC1 1.4341 3.7519 0.7941 16.1073
VAL GDSC1 1.4413 4.8595 0.2791 19.8222
LP-1 GDSC1 1.447 4.1352 0.6291 17.2682
OCI-AML-2 GDSC1 1.4501 4.3453 0.5331 17.9587
HC-1 GDSC1 1.4556 3.6683 0.8538 15.5609
MOLT-13 GDSC1 1.4775 4.0171 0.7145 16.4947
Mono-Mac-6 GDSC1 1.4832 4.4295 0.5252 17.8649
HEL GDSC1 1.5058 3.8857 0.8036 15.6989
BC-3 GDSC1 1.5262 3.6211 0.9461 14.5362
MOLT-4 GDSC1 1.5933 4.9676 0.3706 18.4885
TK [Human B-cell lymphoma] GDSC1 1.5989 4.8988 0.4093 18.1851
Sc-1 GDSC1 1.6068 3.278 1.1826 12.3825
MOLT-16 GDSC1 1.6262 3.1939 1.2396 11.8636
RPMI-6666 GDSC1 1.6295 4.526 0.6189 16.5154
OCI-AML-3 GDSC1 1.651 5.2121 0.305 18.7016
ATN-1 GDSC1 1.6513 4.6848 0.5625 16.8362
OCI-AML-5 GDSC1 1.6964 6.4161 -0.2468 22.183
BC-1 GDSC1 1.7174 3.563 1.163 12.0098
ROS-50 GDSC1 1.7769 4.5341 0.7534 14.865
VL51 GDSC1 1.8974 4.3031 0.9781 12.6378
BALL-1 GDSC1 1.9055 6.732 -0.2178 21.124
MOLP-8 GDSC1 1.9312 4.3379 0.9921 12.3886
BV-173 GDSC1 1.9361 3.9411 1.1912 10.828
A3/Kawakami GDSC1 2.0126 5.2828 0.5975 15.0584
CTB-1 GDSC1 2.0677 21.4821 -7.4482 39.8162
SU-DHL-1 GDSC1 2.0999 2.9435 1.8288 5.19
P12-Ichikawa GDSC1 2.1102 4.9889 0.8296 12.9168
JJN-3 GDSC1 2.1139 3.4848 1.5791 7.0656
THP-1 GDSC1 2.1235 4.3363 1.1661 10.2579
ARH-77 GDSC1 2.1285 4.2165 1.23 9.7383
L-363 GDSC1 2.1343 3.5973 1.5422 7.2705
SUP-T1 GDSC1 2.1715 5.5249 0.6153 14.2993
MN-60 GDSC1 2.2182 3.688 1.572 6.7021
KMS-12-BM GDSC1 2.2376 4.3578 1.2549 9.121
SCC-3 GDSC1 2.2659 2.9306 1.9906 3.2272
EJM GDSC1 2.295 4.9771 0.9944 10.9399
K-562 GDSC1 2.3066 4.5241 1.2306 9.0528
H9 GDSC1 2.3261 7.2421 -0.1119 18.7914
JVM-2 GDSC1 2.3629 5.4251 0.8273 11.9773
DG-75 GDSC1 2.3638 4.2412 1.42 7.3541
SUP-M2 GDSC1 2.3716 4.236 1.4291 7.2547
WSU-DLCL2 GDSC1 2.3845 3.3305 1.8924 3.5561
Jiyoye GDSC1 2.4759 4.7176 1.2736 8.1092
LAMA-84 GDSC1 2.4826 4.5246 1.3754 7.2868
Ramos.2G6.4C10 GDSC1 2.5627 5.732 0.8372 11.1915
MEG-01 GDSC1 2.589 4.0666 1.6864 4.4967
ME1 GDSC1 2.6444 5.5319 1.0016 9.6536
RC-K8 GDSC1 2.7582 4.0591 1.812 3.0356
KCL-22 GDSC1 2.8106 6.3743 0.7121 11.3009
MV4-11 GDSC1 2.8192 4.5903 1.5975 4.4996
Hs 445 GDSC1 2.8272 5.7719 1.0231 8.8955
Granta-519 GDSC1 2.8724 5.4052 1.2375 7.1106
DEL GDSC1 2.9048 4.3136 1.7882 2.8381
L-1236 GDSC1 2.9562 6.1991 0.9089 9.3617
EM-2 GDSC1 2.9576 7.8325 0.1017 15.1491
NOMO-1 GDSC1 3.0531 11.6989 -1.7479 24.8112
Raji GDSC1 3.0882 6.5404 0.8383 9.4901
A4/Fukuda GDSC1 3.0926 7.4018 0.4177 12.5359
RPMI-8226 GDSC1 3.1112 6.4518 0.8984 8.9741
JVM-3 GDSC1 3.1257 6.5124 0.8792 9.0744
HL-60 GDSC1 3.1358 8.1003 0.1051 14.5477
JURL-MK1 GDSC1 3.1727 8.1093 0.1285 14.2745
U266B1 GDSC1 3.2383 6.025 1.1947 6.4006
Karpas-422 GDSC1 3.2658 8.8729 -0.1787 15.9724
P31/FUJ GDSC1 3.4259 5.4967 1.5624 3.2823
KY821 GDSC1 3.537 4.9704 1.8527 1.2358
KM-H2 GDSC1 3.6214 8.4071 0.3093 11.7118
L-428 GDSC1 3.963 7.3359 1.0439 5.737
L-540 GDSC1 4.0918 6.959 1.2896 3.8181
HDLM-2 GDSC1 5.363 7.1647 1.7774 0.2586
⏷ Show the Full List of 144 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC1 -2.1174 0.4277 -2.1651 55.5464
KYAE-1 GDSC1 -0.0025 2.5989 -0.2881 31.2496
OACP4 C GDSC1 1.1581 3.8564 0.4681 19.8254
ESO-26 GDSC1 1.565 4.0579 0.781 15.5949
FLO-1 GDSC1 1.8407 5.8426 0.1667 18.8584
KYSE-50 GDSC1 2.3181 3.9211 1.5418 6.5617
TE-12 GDSC1 2.368 5.1098 0.9892 10.712
ESO-51 GDSC1 2.4992 4.8047 1.249 8.2219
SK-GT-4 GDSC1 2.817 5.4061 1.1961 7.5981
KYSE-220 GDSC1 3.1573 6.7367 0.7924 9.625
HCE-4 GDSC1 5.1997 6.744 1.8629 0.1524
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 0.7075 4.7969 -0.4119 27.8862
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NH-12 GDSC1 0.9241 3.5079 0.3775 21.6554
Kelly GDSC1 1.0574 5.2528 -0.2785 25.3118
SJNB-5 GDSC1 1.1903 3.7608 0.5435 19.1251
SK-N-SH GDSC1 1.337 3.1305 0.9667 15.3118
SJNB-13 GDSC1 1.3422 3.9556 0.6088 17.9118
NB(TU)1 GDSC1 1.4427 4.1982 0.5953 17.537
IMR-5 GDSC1 1.5063 4.7485 0.3945 18.7069
GOTO GDSC1 1.5962 3.5419 1.0525 13.408
SK-N-AS GDSC1 1.6166 3.7445 0.9789 13.8681
TGW GDSC1 1.6826 4.3474 0.7555 15.2586
SJNB-14 GDSC1 1.6969 4.4674 0.711 15.5308
KP-N-YS GDSC1 1.7801 3.4134 1.2946 10.7218
SiMa GDSC1 1.7815 4.6471 0.7025 15.2292
SJNB-7 GDSC1 1.9228 4.1805 1.0617 11.8862
GI-ME-N GDSC1 2.0424 6.5028 0.0159 19.0563
NB69 GDSC1 2.1024 4.1573 1.2363 9.7932
SJNB-17 GDSC1 2.1244 5.8242 0.4254 15.8804
SK-N-MC-IXC GDSC1 2.1543 3.3371 1.6887 6.0434
MHH-NB-11 GDSC1 2.3468 4.4986 1.2771 8.5404
SJNB-10 GDSC1 2.4362 3.9583 1.6207 5.5164
CHP-126 GDSC1 2.5035 7.0568 0.1275 16.5471
SJNB-6 GDSC1 2.5728 5.8897 0.7665 11.6929
SJNB-12 GDSC1 2.7288 5.2541 1.2048 7.8066
CHP-134 GDSC1 2.7976 8.0993 -0.1564 17.3749
NB1 GDSC1 2.8608 6.1156 0.8786 9.8887
KP-N-YN GDSC1 3.0819 7.2884 0.4656 12.2293
SK-N-DZ GDSC1 3.1114 5.3268 1.4433 4.8776
LA-N-6 GDSC1 3.1559 6.9344 0.6945 10.3488
SK-N-FI GDSC1 3.3913 5.2875 1.6368 2.841
CHP-212 GDSC1 4.1417 5.9573 1.7371 1.1264
SK-N-BE(2)-M17 GDSC1 4.2717 5.9999 1.7773 0.8251
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 2.6094 6.1413 0.6702 12.2892
Cancer Drug Sensitivity Data Curated from 51 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC202 GDSC1 0.7478 4.046 -0.0354 25.3675
BT-549 GDSC1 1.1294 5.8576 -0.4987 26.2588
EFM-19 GDSC1 1.1329 4.7231 0.045 22.8808
HCC1937 GDSC1 1.4743 5.7551 -0.1245 22.3877
MDA-MB-453 GDSC1 1.4918 5.0331 0.2433 19.8432
AU565 GDSC1 1.6627 5.3722 0.2374 19.1264
EFM-192A GDSC1 1.7702 6.9116 -0.4266 22.9601
MDA-MB-361 GDSC1 1.8155 4.7934 0.6621 15.3873
HCC1599 GDSC1 1.8423 6.2043 -0.0113 20.0547
MRK-nu-1 GDSC1 1.9367 5.5243 0.4102 16.7413
Evsa-T GDSC1 1.98 4.8771 0.7699 13.8919
YMB-1-E GDSC1 1.9967 4.0323 1.2025 10.4866
BT-474 GDSC1 2.0122 7.3168 -0.4164 21.904
BT-483 GDSC1 2.1609 3.508 1.6104 6.6292
DU4475 GDSC1 2.1668 3.6585 1.5412 7.1476
MDA-MB-175-VII GDSC1 2.3455 3.6835 1.6836 5.3432
OCUB-M GDSC1 2.3868 4.7536 1.1829 9.1347
T-47D GDSC1 2.3914 8.1086 -0.4908 20.8756
HCC38 GDSC1 2.4279 5.8648 0.6613 12.9975
MDA-MB-330 GDSC1 2.4894 5.468 0.9098 10.8908
ZR-75-30 GDSC1 2.492 7.3873 -0.0471 17.7539
HCC1569 GDSC1 2.5318 6.9901 0.1838 16.0596
CAL-120 GDSC1 2.5391 5.4199 0.9739 10.2246
CAL-148 GDSC1 2.5451 5.1008 1.138 8.9317
HCC1395 GDSC1 2.5817 5.499 0.9685 10.1204
HCC1187 GDSC1 2.5875 5.3693 1.0378 9.5657
CAMA-1 GDSC1 2.6034 4.8284 1.3196 7.3183
HCC1419 GDSC1 2.6259 6.3917 0.5586 13.0584
UACC-893 GDSC1 2.6397 5.9194 0.8049 11.1727
HCC2218 GDSC1 2.6533 8.1434 -0.2937 18.7388
HCC70 GDSC1 2.6888 4.3796 1.6065 4.8113
CAL-85-1 GDSC1 2.8295 5.9186 0.9524 9.4284
MDA-MB-157 GDSC1 2.8322 5.0976 1.3591 6.2945
MDA-MB-436 GDSC1 2.8463 6.1838 0.8339 10.2721
MDA-MB-468 GDSC1 2.8883 5.6745 1.1169 7.9882
JIMT-1 GDSC1 2.9128 5.0715 1.4298 5.5174
Hs 578T GDSC1 2.977 4.5491 1.7239 3.1352
HDQ-P1 GDSC1 3.0381 5.5843 1.269 6.3885
UACC-812 GDSC1 3.0467 6.0677 1.0397 8.1019
BT-20 GDSC1 3.0557 5.5323 1.3065 6.0554
HCC1500 GDSC1 3.2202 5.1487 1.5975 3.4823
MDA-MB-415 GDSC1 3.2208 5.3828 1.4885 4.2706
COLO 824 GDSC1 3.24 6.3342 1.0468 7.4986
HCC1954 GDSC1 3.2558 5.2278 1.5829 3.5064
MFM-223 GDSC1 3.5581 5.2794 1.7329 1.9119
HCC1428 GDSC1 3.6416 5.443 1.7066 1.9402
HCC1806 GDSC1 3.7339 8.4092 0.3867 10.8729
CAL-51 GDSC1 3.9842 5.5218 1.8377 0.8149
MDA-MB-231 GDSC1 4.0353 5.913 1.7059 1.4013
HCC2157 GDSC1 4.6885 6.3536 1.8136 0.4265
MCF-7 GDSC1 4.7425 6.4603 1.796 0.4511
⏷ Show the Full List of 51 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AM-38 GDSC1 0.9535 4.065 0.1669 22.9563
YH-13 GDSC1 1.2649 4.0797 0.4745 19.2582
D-336MG GDSC1 1.7247 3.6544 1.1273 12.2475
MOG-G-CCM GDSC1 1.9317 4.4684 0.9283 12.8782
CAS-1 GDSC1 2.0312 4.5219 0.9918 11.981
NMC-G1 GDSC1 2.0376 3.9105 1.2997 9.5605
KS-1 [Human Krukenberg tumour] GDSC1 2.0766 4.0176 1.2823 9.5376
DK-MG GDSC1 2.1247 3.1248 1.7652 5.5722
GI-1 GDSC1 2.1321 3.3802 1.6472 6.4589
GB-1 GDSC1 2.1451 3.1052 1.7939 5.2624
KNS-42 GDSC1 2.1482 4.5758 1.0686 10.9215
U-87MG ATCC GDSC1 2.1757 4.2559 1.252 9.3814
GaMG GDSC1 2.2325 4.5763 1.1414 10.0291
KINGS-1 GDSC1 2.3114 4.313 1.3402 8.1742
D-566MG GDSC1 2.3375 3.7666 1.6353 5.7526
D-502MG GDSC1 2.3654 3.9224 1.5808 6.0815
ONS-76 GDSC1 2.4012 3.4385 1.8521 3.815
A-172 GDSC1 2.4423 4.2066 1.5017 6.4331
U-251MG GDSC1 2.4784 4.0225 1.6225 5.3585
U-118MG GDSC1 2.5852 4.9863 1.2267 8.1046
D-392MG GDSC1 2.6387 5.5057 1.0102 9.6067
D-423MG GDSC1 2.6835 6.3962 0.602 12.5409
LN-229 GDSC1 2.8193 4.0981 1.8343 2.7094
T98G GDSC1 2.829 4.699 1.5516 4.8233
LN-405 GDSC1 2.8549 4.3472 1.7393 3.327
Hs 683 GDSC1 2.9135 4.914 1.5067 4.9291
MOG-G-UVW GDSC1 2.9263 4.5252 1.7021 3.4221
SF126 GDSC1 2.9465 5.1404 1.42 5.4971
D-263MG GDSC1 2.9593 4.8413 1.5732 4.3016
KNS-81-FD GDSC1 3.0084 5.7509 1.1668 7.2497
8-MG-BA GDSC1 3.0324 5.475 1.318 6.0326
Becker GDSC1 3.0677 5.5444 1.309 6.0033
SF295 GDSC1 3.11 5.4384 1.389 5.287
SK-MG-1 GDSC1 3.1659 5.6217 1.3389 5.5149
YKG-1 GDSC1 3.1836 5.3006 1.5032 4.2529
Daoy GDSC1 3.1941 6.375 0.9949 8.0136
SF268 GDSC1 3.2721 6.846 0.8212 9.0794
LNZTA3WT4 GDSC1 3.2993 6.0182 1.2389 5.9124
Onda 10 GDSC1 3.328 5.9482 1.2911 5.455
Onda 11 GDSC1 3.3849 6.0267 1.2911 5.3148
42-MG-BA GDSC1 3.4084 6.7678 0.9537 7.7294
SW1088 GDSC1 3.4427 6.8517 0.9367 7.7618
D-247MG GDSC1 3.4498 5.5573 1.5491 3.3253
D-542MG GDSC1 3.5556 5.2076 1.7623 1.7358
M059J GDSC1 3.603 6.6814 1.1234 6.002
SF539 GDSC1 3.6805 8.3106 0.3974 10.9465
LN-18 GDSC1 3.7025 4.7895 1.9972 0.3939
KALS-1 GDSC1 3.8685 10.2957 -0.4346 15.7119
H4 GDSC1 3.8731 6.85 1.2122 4.7687
SW1783 GDSC1 3.9876 6.035 1.6327 1.8645
PFSK-1 GDSC1 4.3013 10.1307 -0.0539 12.2381
DBTRG-05MG GDSC1 4.3923 8.8196 0.6226 7.6465
D283 Med GDSC1 4.5434 5.8381 1.9405 0.1778
SNB-75 GDSC1 5.6627 7.3867 1.8065 0.1439
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 1.5082 4.2482 0.6356 16.9375
TGBC24TKB GDSC1 2.5433 6.7849 0.2957 15.2401
TGBC1TKB GDSC1 3.1225 5.6042 1.3179 5.7877
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-280 GDSC1 1.6065 5.5405 0.103 20.2979
AN3-CA GDSC1 1.9834 3.4306 1.4836 8.3621
RL95-2 GDSC1 2.1339 4.3466 1.1701 10.1856
KLE GDSC1 2.1911 5.4156 0.6868 13.6873
EN GDSC1 2.4819 6.9585 0.1589 16.411
MFE-296 GDSC1 2.7131 4.3792 1.6245 4.5991
MFE-319 GDSC1 2.8738 4.7693 1.549 4.7168
ESS-1 GDSC1 4.6103 6.5066 1.7268 0.764
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-1M GDSC1 0.6807 2.7814 0.3961 22.8372
HA7-RCC GDSC1 0.9826 4.0197 0.2167 22.4683
786-O GDSC1 1.4816 5.1975 0.1539 20.5076
KTCTL-21 GDSC1 1.4901 4.6242 0.4387 18.4616
769-P GDSC1 1.7406 2.3704 1.6804 8.0899
KTCTL-26A GDSC1 1.8236 3.699 1.202 11.2325
LB1047-RCC GDSC1 2.129 4.1465 1.2653 9.4603
UO-31 GDSC1 2.1767 4.2227 1.2694 9.241
ACHN GDSC1 2.3187 4.7426 1.1316 9.7839
RXF 393L GDSC1 2.3429 6.2149 0.4157 15.1157
KTCTL-140 GDSC1 2.3482 3.9552 1.55 6.3861
A-704 GDSC1 2.4445 4.9765 1.1188 9.4299
VMRC-RCW GDSC1 2.5383 4.3208 1.5212 5.9537
NCC021 GDSC1 2.5524 4.2957 1.5447 5.7229
KMRC-1 GDSC1 2.5788 4.0322 1.6957 4.4557
BB65-RCC GDSC1 2.8741 4.9696 1.4519 5.4588
BFTC-909 GDSC1 2.9853 6.3031 0.8793 9.4953
Caki-1 GDSC1 3.0448 7.2928 0.4356 12.5596
VMRC-RCZ GDSC1 3.063 5.6796 1.2403 6.5367
LB2241-RCC GDSC1 3.1232 5.5634 1.338 5.6349
SW156 GDSC1 3.1579 7.1756 0.5776 11.1922
LB996-RCC GDSC1 3.1715 5.2216 1.5326 4.0671
RCC10RGB GDSC1 3.3346 7.2111 0.6878 9.8731
OS-RC-2 GDSC1 3.4268 7.7864 0.4733 11.1367
KMRC-20 GDSC1 3.6547 5.9166 1.5063 3.2075
CAL-54 GDSC1 4.0156 11.9862 -1.1557 19.1776
KTCTL-195 GDSC1 4.0916 7.2896 1.1417 4.7996
TK-10 GDSC1 4.2004 7.446 1.1342 4.6343
SN12C GDSC1 4.2237 6.0515 1.7366 1.0469
A-498 GDSC1 4.2382 6.1546 1.7026 1.1922
SW13 GDSC1 4.8534 6.4943 1.8254 0.3239
KTCTL-13 GDSC1 5.1674 6.8861 1.8032 0.2652
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-175 GDSC1 0.8019 5.5459 -0.6661 28.803
SNU-407 GDSC1 1.0545 4.3022 0.162 22.4807
LS513 GDSC1 1.4193 4.2103 0.5667 17.8563
GP5d GDSC1 1.5685 3.5823 1.0062 13.8865
NCI-H716 GDSC1 1.6233 4.8074 0.4766 17.5894
CCK-81 GDSC1 1.8845 3.6365 1.2903 10.2852
NCI-H747 GDSC1 2.0113 4.3401 1.064 11.5029
T84 GDSC1 2.025 3.6489 1.4166 8.7025
LS411N GDSC1 2.071 5.2103 0.6849 14.1702
COLO 320HSR GDSC1 2.0816 4.6244 0.9858 11.8262
SNU-1040 GDSC1 2.0846 5.7369 0.4344 15.9712
RKO GDSC1 2.1858 5.1496 0.8151 12.7344
HCT 15 GDSC1 2.3302 3.2709 1.877 3.8742
KM12 GDSC1 2.475 4.8908 1.1865 8.7945
SW948 GDSC1 2.5664 4.1332 1.6362 4.9607
COLO205 GDSC1 2.5883 3.8838 1.7761 3.7991
C2BBe1 GDSC1 2.6596 4.9725 1.2914 7.3552
SW837 GDSC1 2.7328 4.6382 1.5118 5.4125
LS1034 GDSC1 2.8117 8.8828 -0.5357 19.6279
CaR-1 GDSC1 2.9996 5.2565 1.4009 5.4946
SW620 GDSC1 3.003 5.8533 1.113 7.675
SNU-C1 GDSC1 3.0267 5.2904 1.4033 5.4029
HCC2998 GDSC1 3.0353 5.0348 1.5318 4.4131
SW48 GDSC1 3.0555 6.2117 0.9756 8.5597
LoVo GDSC1 3.0662 4.8672 1.6315 3.5964
SNU-C5 GDSC1 3.1104 5.3636 1.425 5.0167
HCT 116 GDSC1 3.157 6.4337 0.9402 8.5285
CW-2 GDSC1 3.2089 7.824 0.2963 13.0209
SW1417 GDSC1 3.2252 6.5277 0.9428 8.3138
HT-29 GDSC1 3.227 6.4956 0.9596 8.1841
HT-55 GDSC1 3.3627 5.3699 1.5826 3.275
LS123 GDSC1 3.3835 5.7939 1.3994 4.5318
SNU-81 GDSC1 3.4128 6.2471 1.2051 5.8739
SNU-61 GDSC1 3.4377 10.3985 -0.8031 19.0717
SW626 GDSC1 3.5749 7.7334 0.603 9.8058
SNU-C2B GDSC1 3.6885 8.9259 0.1045 12.8864
MDST8 GDSC1 3.991 9.695 -0.0563 13.0741
COLO 678 GDSC1 4.0857 7.0262 1.2563 4.0474
HT115 GDSC1 4.2278 5.3868 1.983 0.187
LS180 GDSC1 4.5231 6.1886 1.8093 0.5283
SW1116 GDSC1 4.7497 6.2323 1.8788 0.2395
CL-11 GDSC1 4.7815 6.8365 1.6735 0.843
RCM-1 [Human ESC] GDSC1 5.008 6.3611 1.9251 0.1031
SW1463 GDSC1 5.0942 6.7152 1.8358 0.2227
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 1.8357 6.8383 -0.3322 22.1196
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-475 GDSC1 0.7413 3.7797 0.0724 24.6969
SNU-398 GDSC1 0.8251 4.1516 -0.0026 24.7476
JHH-1 GDSC1 1.2739 3.6952 0.6578 17.8841
HLE GDSC1 1.5951 4.5854 0.5575 17.1222
JHH-4 GDSC1 1.9651 3.9035 1.2366 10.354
JHH-6 GDSC1 2.3906 4.7175 1.2041 8.955
SNU-387 GDSC1 2.4661 4.2953 1.4766 6.5482
JHH-7 GDSC1 2.8937 4.5296 1.6782 3.6846
Hep 3B2.1-7 GDSC1 3.0589 5.3072 1.4173 5.2103
SNU-423 GDSC1 3.2377 6.4554 0.9866 7.9529
SK-HEP-1 GDSC1 3.2694 5.0066 1.6925 2.7065
SNU-449 GDSC1 3.3384 6.1328 1.2103 6.0237
JHH-2 GDSC1 3.4467 5.6573 1.5016 3.6626
Hep-G2/C3A GDSC1 3.9936 5.456 1.867 0.6819
HuH-1 GDSC1 4.3136 5.5673 1.9515 0.2272
Huh-7 GDSC1 4.985 6.3805 1.9108 0.1256
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 170 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H446 GDSC1 -0.9189 2.3543 -1.2175 42.1332
NCI-H1688 GDSC1 -0.5365 3.4796 -1.1656 39.0706
NCI-H1755 GDSC1 -0.21 2.3427 -0.4407 33.4551
NCI-H520 GDSC1 -0.1952 3.4764 -0.7981 35.2119
NCI-H2110 GDSC1 0.0814 2.4304 -0.147 29.8748
NCI-H1048 GDSC1 0.3839 2.1939 0.2458 25.5454
DMS 273 GDSC1 0.7462 3.4179 0.2274 23.6306
NCI-H847 GDSC1 0.9742 3.2325 0.543 20.2298
Lu-165 GDSC1 0.9843 5.7914 -0.6057 27.5619
NCI-H2196 GDSC1 0.9949 4.6158 -0.0415 24.1313
NCI-H2030 GDSC1 1.008 3.61 0.4217 20.9113
NCI-H1563 GDSC1 1.0776 4.9207 -0.102 24.1113
IST-SL1 GDSC1 1.0955 4.0481 0.3186 21.1945
NCI-H2172 GDSC1 1.1926 6.1417 -0.5763 26.395
NCI-H2227 GDSC1 1.226 3.7885 0.5675 18.7756
NCI-H1437 GDSC1 1.2537 4.0508 0.4766 19.2967
HOP-62 GDSC1 1.2807 3.2198 0.8707 16.2961
NCI-H211 GDSC1 1.3048 3.8965 0.5983 18.168
NCI-H1944 GDSC1 1.3165 4.0031 0.5613 18.382
SBC-1 GDSC1 1.3576 5.3538 -0.0389 22.3666
NCI-H292 GDSC1 1.3801 5.3202 -0.0012 22.0151
NCI-H2731 GDSC1 1.4013 4.6944 0.3199 19.7185
NCI-H64 GDSC1 1.4126 3.112 1.0537 14.2941
COR-L105 GDSC1 1.5699 5.8368 -0.0762 21.65
NCI-H513 GDSC1 1.6195 6.5826 -0.3986 23.438
NCI-H2228 GDSC1 1.6446 4.3969 0.6955 15.8772
SW1271 GDSC1 1.6578 4.5032 0.6567 16.1091
Lu-135 GDSC1 1.7113 3.9254 0.9857 13.3862
NCI-H727 GDSC1 1.7272 4.5291 0.7095 15.4103
NCI-H647 GDSC1 1.728 4.3399 0.8021 14.7083
NCI-H2795 GDSC1 1.7514 7.5289 -0.75 24.8624
LK-2 GDSC1 1.7615 3.896 1.048 12.6873
NCI-H522 GDSC1 1.8483 4.2552 0.956 13.0156
SBC-3 GDSC1 1.8494 2.899 1.5981 8.1092
Lu-65 GDSC1 1.8684 3.1207 1.5178 8.6198
HCC44 GDSC1 1.8789 2.9253 1.6167 7.8276
UMC-11 GDSC1 1.9531 4.3433 1.0095 12.1637
COR-L303 GDSC1 1.9554 2.6568 1.8115 6.0094
SBC-5 GDSC1 1.9723 3.1799 1.5928 7.5713
NCI-H1155 GDSC1 1.9736 3.7417 1.3235 9.6439
EBC-1 GDSC1 1.9814 3.8284 1.2884 9.8828
LCLC-97TM1 GDSC1 1.9959 4.3682 1.0361 11.7821
EMC-BAC-1 GDSC1 2.0091 6.0243 0.2254 17.7607
RERF-LC-KJ GDSC1 2.015 4.4248 1.0253 11.7876
Lu-99A GDSC1 2.0181 5.4005 0.5438 15.4346
CAL-12T GDSC1 2.0508 4.6224 0.9594 12.1531
LC-2/ad GDSC1 2.0516 3.5657 1.482 8.0824
Ms-1 GDSC1 2.1454 6.2149 0.2484 17.0597
COR-L321 GDSC1 2.1454 3.9678 1.3686 8.5856
PC-14 GDSC1 2.1609 3.7663 1.4824 7.6323
NCI-H1993 GDSC1 2.1923 6.3613 0.2154 17.1077
NCI-H841 GDSC1 2.2442 4.2625 1.3082 8.6774
NCI-H2135 GDSC1 2.2695 5.2763 0.8233 12.354
SHP-77 GDSC1 2.292 4.0654 1.4475 7.4015
NCI-H1703 GDSC1 2.3019 4.0268 1.4752 7.1459
NCI-H1876 GDSC1 2.3041 4.4659 1.2577 8.8497
ChaGo-K-1 GDSC1 2.3071 4.3342 1.3259 8.3022
HARA [Human squamous cell lung carcinoma] GDSC1 2.33 4.6301 1.1974 9.2274
NCI-H2869 GDSC1 2.3433 6.8571 0.0949 17.3589
NCI-H1792 GDSC1 2.3635 4.5352 1.2727 8.5143
NCI-H1975 GDSC1 2.3754 6.2945 0.403 15.0867
NCI-H1581 GDSC1 2.3835 4.958 1.0779 9.9668
COR-L311 GDSC1 2.3957 4.9236 1.1053 9.7096
Lu-139 GDSC1 2.4009 6.7624 0.1902 16.493
NCI-H2085 GDSC1 2.4325 5.5697 0.8125 11.8384
CPC-N GDSC1 2.435 9.7325 -1.2665 24.792
NCI-H1436 GDSC1 2.4493 4.3531 1.4342 6.94
NCI-H838 GDSC1 2.4644 4.7031 1.2716 8.1648
NCI-H2347 GDSC1 2.4827 4.9385 1.1688 8.9059
COR-L23 GDSC1 2.4931 5.3624 0.9655 10.4491
EPLC-272H GDSC1 2.5148 4.9956 1.1662 8.8156
NCI-H209 GDSC1 2.5151 4.5691 1.3792 7.1462
NCI-H358 GDSC1 2.5162 5.6356 0.8478 11.2726
BEN GDSC1 2.5246 4.8069 1.2682 7.9848
NCI-H596 GDSC1 2.5259 5.2944 1.026 9.8674
DMS 114 GDSC1 2.5275 5.1095 1.1195 9.1355
NCI-H526 GDSC1 2.5383 8.589 -0.6099 21.0203
NCI-H23 GDSC1 2.5605 3.8763 1.7589 4.0198
NCI-H1648 GDSC1 2.5645 5.2912 1.0584 9.4838
COR-L95 GDSC1 2.5899 5.7608 0.8445 11.0423
NCI-H661 GDSC1 2.6036 6.907 0.2835 15.1113
NCI-H2009 GDSC1 2.624 4.2647 1.6148 4.9453
SK-LU-1 GDSC1 2.6291 5.1237 1.1927 8.2236
NCI-H1694 GDSC1 2.6317 4.7316 1.3895 6.6803
LCLC-103H GDSC1 2.6318 5.1165 1.1985 8.1701
RERF-LC-MS GDSC1 2.6471 5.4017 1.0686 9.1276
NCI-H748 GDSC1 2.6499 4.667 1.4355 6.2629
NCI-H3255 GDSC1 2.6761 5.0383 1.2715 7.4573
NCI-H1666 GDSC1 2.6789 4.9516 1.3167 7.0968
NCI-H1573 GDSC1 2.7164 5.3148 1.1653 8.1529
NCI-H810 GDSC1 2.7175 6.8865 0.3846 14.0009
ABC-1 GDSC1 2.7768 4.8608 1.4348 5.876
COR-L88 GDSC1 2.7854 7.4404 0.1623 15.318
NCI-H1770 GDSC1 2.7861 4.1369 1.7936 3.1
LOU-NH91 GDSC1 2.8048 4.4055 1.677 3.9333
NCI-H2171 GDSC1 2.8267 5.5238 1.1453 7.9591
NCI-H2804 GDSC1 2.8323 6.617 0.6084 11.9964
EMC-BAC-2 GDSC1 2.8357 6.1207 0.8571 10.1315
COLO 668 GDSC1 2.8565 6.5336 0.6684 11.4753
NCI-H1092 GDSC1 2.8726 5.1909 1.3427 6.3008
NCI-H82 GDSC1 2.8765 5.6577 1.1164 8.028
LXF 289 GDSC1 2.908 4.5988 1.6547 3.8234
NCI-H196 GDSC1 2.9116 5.0079 1.4598 5.2917
NCI-H226 GDSC1 2.9244 4.7402 1.598 4.2074
NCI-H1623 GDSC1 2.9255 6.2516 0.8602 9.8244
NCI-H2591 GDSC1 2.9335 6.8191 0.5857 11.8346
NCI-H2369 GDSC1 2.9373 5.43 1.2725 6.6498
HCC78 GDSC1 2.9436 8.0218 -0.0033 15.8915
NCI-H1869 GDSC1 2.9771 5.1032 1.4593 5.1138
NCI-H2023 GDSC1 2.9804 6.6048 0.727 10.6472
NCI-H2444 GDSC1 3.0529 5.0104 1.5551 4.1943
NCI-H1355 GDSC1 3.0687 4.8437 1.6442 3.4975
NCI-H2122 GDSC1 3.1159 6.8397 0.7117 10.343
NCI-H1836 GDSC1 3.1589 4.7364 1.7498 2.5385
NCI-H2029 GDSC1 3.1618 5.5904 1.3511 5.4346
SK-MES-1 GDSC1 3.2573 5.8021 1.3139 5.4654
NCI-H3122 GDSC1 3.2655 6.1677 1.1446 6.7011
A-427 GDSC1 3.2839 7.3774 0.5704 10.8659
NCI-H187 GDSC1 3.3355 6.8933 0.8428 8.7413
A-549 GDSC1 3.3393 5.0146 1.7293 2.3187
NCI-H2595 GDSC1 3.3699 6.0918 1.2505 5.6484
Calu-6 GDSC1 3.3761 7.3465 0.6514 10.0171
NCI-H2087 GDSC1 3.3915 6.972 0.8437 8.5794
NCI-H650 GDSC1 3.3917 6.7838 0.9346 7.9139
Calu-3 GDSC1 3.4198 5.4431 1.5831 3.152
NCI-H1734 GDSC1 3.4424 8.0614 0.3503 11.9458
NCI-H460 GDSC1 3.453 5.9921 1.3507 4.7209
NCI-H2405 GDSC1 3.462 5.7975 1.4465 4.0175
NCI-H1915 GDSC1 3.4729 7.2803 0.7512 9.0277
DMS 79 GDSC1 3.4785 7.9837 0.4141 11.4006
NCI-H1793 GDSC1 3.4795 5.5196 1.5835 3.029
NCI-H1435 GDSC1 3.4811 7.0526 0.8664 8.1718
PaCa-3 GDSC1 3.4921 6.9977 0.9002 7.8966
NCI-H441 GDSC1 3.4923 6.5633 1.1074 6.3887
HCC33 GDSC1 3.5045 7.195 0.814 8.4885
NCI-H2373 GDSC1 3.511 7.4568 0.6923 9.3455
NCI-H1650 GDSC1 3.5111 6.5853 1.1093 6.328
NCI-H345 GDSC1 3.5317 4.5912 2.0013 0.5048
HCC827 GDSC1 3.5732 5.8527 1.4878 3.4937
NCI-H322M GDSC1 3.5791 7.722 0.6113 9.7353
NCI-H2461 GDSC1 3.6122 7.5596 0.7121 8.9313
NCI-H510A GDSC1 3.6142 5.8288 1.5224 3.1774
NCI-H2722 GDSC1 3.6157 6.4491 1.2398 5.1392
RERF-LC-Sq1 GDSC1 3.6866 6.7117 1.1621 5.5292
HCC15 GDSC1 3.732 6.6981 1.1965 5.1834
NCI-H1568 GDSC1 3.7967 6.1888 1.4654 3.2106
NCI-H2803 GDSC1 3.7996 5.6168 1.7137 1.6634
NCI-H2342 GDSC1 3.803 6.0217 1.5424 2.7004
NCI-H1838 GDSC1 3.8422 6.1524 1.5066 2.8607
NCI-H1693 GDSC1 3.8555 8.0927 0.6206 8.941
IA-LM GDSC1 3.9079 5.4606 1.8281 0.9317
EKVX GDSC1 3.9263 6.85 1.2436 4.4442
SW1573 GDSC1 3.9309 6.3605 1.464 2.979
Lu-134-A GDSC1 4.0769 9.4429 0.124 11.6964
NCI-H2170 GDSC1 4.1376 7.6659 0.9981 5.6749
NCI-H720 GDSC1 4.2858 5.5408 1.9506 0.2394
NCI-H2141 GDSC1 4.3383 6.201 1.7286 0.9762
LC-1/sq GDSC1 4.3923 6.8619 1.4888 2.1243
NCI-H1304 GDSC1 4.581 5.8315 1.956 0.1413
NCI-H2081 GDSC1 4.6063 6.5346 1.7147 0.8136
NCI-H2818 GDSC1 4.615 6.3272 1.7948 0.5223
NCI-H1781 GDSC1 4.7117 6.2693 1.8521 0.3139
NCI-H1299 GDSC1 4.7723 8.9724 0.7786 5.8429
NCI-H69 GDSC1 4.8873 6.8565 1.7087 0.6459
DMS 53 GDSC1 4.9339 6.7767 1.7556 0.474
NCI-H2291 GDSC1 4.9619 6.8698 1.7329 0.5269
HOP-92 GDSC1 5.0825 7.2242 1.6512 0.7212
NCI-H524 GDSC1 5.1472 6.7275 1.8502 0.1836
NCI-H1651 GDSC1 5.319 7.3432 1.6993 0.4529
NCI-H1963 GDSC1 5.3263 7.0757 1.7948 0.2359
⏷ Show the Full List of 170 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 0.9605 5.0429 -0.2742 25.7671
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE33 GDSC1 1.3175 4.942 0.1209 21.4882
KYSE-450 GDSC1 2.1141 3.1336 1.751 5.7283
T.T GDSC1 2.1367 3.8842 1.4023 8.3564
TE-10 GDSC1 2.414 4.5387 1.3127 8.0188
KYSE-140 GDSC1 2.4813 6.1086 0.5832 13.3864
TE-15 GDSC1 2.4856 5.4829 0.8993 10.9856
TE-8 GDSC1 2.6497 5.0335 1.2535 7.6826
KYSE-520 GDSC1 2.7303 4.5593 1.5487 5.1341
TE-6 GDSC1 2.8144 7.7708 0.0206 16.1704
KYSE-180 GDSC1 2.9937 5.4965 1.2804 6.4277
KYSE-270 GDSC1 3.2016 8.5973 -0.0909 15.62
TE-5 GDSC1 3.2029 6.4799 0.9502 8.3217
EC-GI-10 GDSC1 3.3497 5.6049 1.4662 4.1285
KYSE-510 GDSC1 3.5099 7.8062 0.5225 10.554
TE-9 GDSC1 3.5233 5.734 1.5123 3.4278
TE-11 GDSC1 3.5434 10.0175 -0.5357 17.2566
TE-1 GDSC1 3.5723 5.4391 1.6713 2.2756
KYSE-70 GDSC1 3.7565 6.864 1.1348 5.5623
KYSE-410 GDSC1 3.8131 8.7211 0.2909 11.3047
KYSE-150 GDSC1 3.9218 6.565 1.3688 3.6142
OE19 GDSC1 3.993 5.5863 1.8165 0.9021
TE-4 GDSC1 4.0664 6.0175 1.6782 1.5097
OE21 GDSC1 4.1006 8.8588 0.4184 9.7
COLO 680N GDSC1 4.5714 6.3343 1.775 0.6149
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IGROV-1 GDSC1 0.1955 3.3825 -0.3443 30.3731
OVKATE GDSC1 0.9652 5.6091 -0.5372 27.2775
OVCAR-8 GDSC1 1.1902 4.7707 0.0788 22.3777
A2780 GDSC1 1.4974 3.9772 0.7526 16.1184
TOV-112D GDSC1 1.5208 2.9632 1.2287 12.4686
RMG-I GDSC1 1.9865 6.5148 -0.0387 19.6424
TYK-nu GDSC1 2.0975 4.08 1.2703 9.5469
OV56 GDSC1 2.1265 3.0135 1.8208 5.1343
FU-OV-1 GDSC1 2.1476 5.6297 0.5425 14.9325
JHOS-2 GDSC1 2.1933 3.5676 1.6099 6.5027
OV-90 GDSC1 2.3343 4.2743 1.3788 7.7858
ES-2 GDSC1 2.434 3.3967 1.8992 3.3312
DOV13 GDSC1 2.5699 5.1237 1.1462 8.7832
Caov-3 GDSC1 2.6445 4.4832 1.5223 5.6025
TOV-21G GDSC1 2.7747 4.1772 1.7664 3.3356
OC 314 GDSC1 2.7778 4.3736 1.6735 4.0349
EFO-21 GDSC1 2.7946 7.0185 0.3796 13.7751
OAW42 GDSC1 2.8501 4.1457 1.832 2.6501
OAW28 GDSC1 2.8773 8.1263 -0.1069 16.7864
SK-OV-3 GDSC1 2.8841 5.8111 1.0465 8.5396
Caov-4 GDSC1 2.9108 6.3973 0.7771 10.4932
Kuramochi GDSC1 2.9122 7.8915 0.0372 15.7296
OVCAR-4 GDSC1 2.939 7.0634 0.4689 12.6608
OVISE GDSC1 3.0413 7.7859 0.189 14.2859
OVK18 GDSC1 3.4431 9.0943 -0.1556 15.2777
OVTOKO GDSC1 3.526 6.1766 1.3106 4.84
OVCAR-5 GDSC1 3.5781 6.8525 1.0266 6.7597
EFO-27 GDSC1 3.9282 9.0539 0.2096 11.5336
OVCAR-3 GDSC1 4.4262 6.082 1.81 0.5855
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Panc 02.03 GDSC1 1.9522 4.5479 0.9078 12.9513
SUIT-2 GDSC1 1.9543 4.5556 0.9059 12.9573
MZ-PC-1 GDSC1 1.9865 4.3902 1.0168 11.97
PSN1 GDSC1 2.0039 8.2251 -0.8768 24.5023
Panc 08.13 GDSC1 2.3182 4.6914 1.1568 9.5888
DAN-G GDSC1 2.3185 3.931 1.5372 6.5964
Panc 10.05 GDSC1 2.3257 4.0532 1.4821 7.0039
QGP-1 GDSC1 2.333 5.5701 0.7298 12.8288
AsPC-1 GDSC1 2.4173 5.6392 0.7653 12.2519
BxPC-3 GDSC1 2.5146 5.4228 0.9528 10.4726
KP-3 GDSC1 2.713 5.1519 1.2434 7.5579
HuP-T4 GDSC1 2.7593 5.3561 1.1775 7.9223
CFPAC-1 GDSC1 2.773 4.7539 1.4844 5.5039
HPAF-II GDSC1 2.819 4.4722 1.6546 4.064
HuP-T3 GDSC1 2.9043 6.4306 0.7558 10.673
HPAC GDSC1 3.0082 5.1754 1.446 5.1302
PaTu 8988t GDSC1 3.0887 5.4934 1.3481 5.6512
PaTu 8902 GDSC1 3.1182 5.8435 1.1994 6.6912
Capan-2 GDSC1 3.1265 5.5121 1.3649 5.4245
PL4 GDSC1 3.1725 5.7283 1.2923 5.8461
Capan-1 GDSC1 3.216 5.0612 1.6353 3.2214
KP-2 GDSC1 3.2292 5.2007 1.5789 3.5952
Panc 04.03 GDSC1 3.2613 5.1887 1.6043 3.3414
MIA PaCa-2 GDSC1 3.2969 4.9501 1.7339 2.3685
Panc 03.27 GDSC1 3.6438 7.4127 0.8037 8.1951
Hs 766T GDSC1 3.7 5.611 1.6651 2.1017
YAPC GDSC1 3.7465 7.3306 0.9102 7.1773
SU.86.86 GDSC1 3.7652 5.653 1.6811 1.904
KP-4 GDSC1 3.8512 5.3047 1.864 0.8208
SW1990 GDSC1 4.9622 6.9196 1.7151 0.5818
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IST-Mes1 GDSC1 1.8577 8.0809 -0.9315 25.3718
MPP 89 GDSC1 2.8619 5.0874 1.3856 6.0026
NCI-H28 GDSC1 3.3703 7.4057 0.6185 10.2695
NCI-H2052 GDSC1 3.5822 6.7197 1.092 6.2781
NCI-H2452 GDSC1 5.1889 7.2117 1.6971 0.5184
MSTO-211H GDSC1 5.5771 7.7093 1.6661 0.431
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 1.2872 4.9334 0.0958 21.801
VCaP GDSC1 1.5787 4.2436 0.706 16.0937
22Rv1 GDSC1 1.8367 5.9789 0.0956 19.3616
PC-3 GDSC1 2.4065 5.1429 1.0045 10.4546
DU145 GDSC1 3.3687 5.6333 1.4649 4.0946
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.2297 6.1776 1.6897 1.2639
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
WM115 GDSC1 0.0992 4.3989 -0.8583 33.6544
CHL-1 GDSC1 0.8154 3.8575 0.116 24.0142
WM278 GDSC1 0.901 5.3024 -0.4544 27.1306
MZ-MEL-2 GDSC1 0.9598 3.9352 0.2308 22.4876
Mel Ho GDSC1 1.3185 3.206 0.916 15.7754
WM35 GDSC1 1.3861 3.1869 0.9946 14.8598
SK-MEL-24 GDSC1 1.4401 4.7789 0.3167 19.5624
IGR-37 GDSC1 1.4594 4.1624 0.6285 17.2153
SK-MEL-3 GDSC1 1.472 6.4745 -0.4794 24.5622
M14 GDSC1 1.4921 6.018 -0.2368 23.0161
MZ-MEL-7 GDSC1 1.6877 4.5272 0.6733 15.8535
UACC-257 GDSC1 1.71 4.4673 0.7234 15.3805
CP50-MEL-B GDSC1 1.7758 6.1551 -0.0463 20.5643
IGR-1 GDSC1 1.7803 3.8842 1.0717 12.4234
RPMI-7951 GDSC1 1.9784 3.3793 1.5035 8.2302
RVH-421 GDSC1 2.053 7.5722 -0.5086 22.2824
IST-MEL1 GDSC1 2.0611 5.4974 0.5334 15.3397
A101D GDSC1 2.1491 3.4352 1.6357 6.4789
GAK GDSC1 2.235 4.6862 1.0886 10.4321
LB373-MEL-D GDSC1 2.2647 4.5731 1.1706 9.6793
A-431 GDSC1 2.2825 4.2377 1.3533 8.1783
SH-4 GDSC1 2.3775 9.734 -1.315 25.2271
IPC-298 GDSC1 2.4218 3.5184 1.8288 3.9268
CP66-MEL GDSC1 2.4595 5.6069 0.816 11.7149
SK-MEL-28 GDSC1 2.4986 5.3242 0.9891 10.2483
HMV-II GDSC1 2.5257 7.7792 -0.2154 18.7102
G-361 GDSC1 2.5388 4.5752 1.3949 6.9433
LB2518-MEL GDSC1 2.5476 3.8152 1.7793 3.9014
SK-MEL-2 GDSC1 2.6023 3.6663 1.8931 2.851
SK-MEL-1 GDSC1 2.6072 4.001 1.7325 4.0808
A-388 GDSC1 2.6625 4.2825 1.6348 4.6708
SK-MEL-30 GDSC1 2.6694 6.092 0.7424 11.5438
COLO 792 GDSC1 2.6856 6.6826 0.461 13.5627
A2058 GDSC1 2.6917 3.6656 1.9555 2.1312
A-375 GDSC1 2.6996 4.2921 1.6574 4.3848
451Lu GDSC1 2.8027 4.6648 1.5495 4.9149
COLO 800 GDSC1 2.8753 5.3844 1.2499 7.0071
G-mel GDSC1 2.9156 5.115 1.4106 5.6563
DJM-1 GDSC1 2.976 5.3107 1.3582 5.8853
HT-144 GDSC1 2.9764 5.9268 1.0576 8.1745
Mel JuSo GDSC1 3.0356 5.8281 1.1487 7.3088
LOX-IMVI GDSC1 3.3452 5.6798 1.4285 4.4107
MMAc-SF GDSC1 3.4381 7.926 0.4133 11.5224
SK-MEL-5 GDSC1 3.523 7.1987 0.8247 8.3614
Hs 938.T GDSC1 3.577 5.6723 1.571 2.9232
UACC-62 GDSC1 3.5806 5.1267 1.8092 1.4222
VMRC-MELG GDSC1 3.6967 5.3049 1.7924 1.3595
COLO 829 GDSC1 3.7253 8.281 0.4426 10.5139
COLO 679 GDSC1 3.775 9.6332 -0.1784 14.4392
MeWo GDSC1 3.8521 6.0451 1.5586 2.5148
COLO 783 GDSC1 3.9677 5.5601 1.8156 0.9309
WM1552C GDSC1 4.3052 6.2798 1.6833 1.2158
WT2-iPS GDSC1 4.4945 5.8592 1.9158 0.2443
Hs 940.T GDSC1 4.7891 6.5352 1.7869 0.4544
WM793 GDSC1 5.0204 13.7828 -1.3182 17.3078
EquiPSC Line K2 GDSC1 3.4854 5.659 1.5239 3.4254
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 1.9386 3.3784 1.4658 8.6959
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EW-8 GDSC1 0.6683 3.6164 0.0644 25.1422
A-204 GDSC1 1.269 3.6948 0.653 17.9432
RD GDSC1 2.0061 3.8693 1.2911 9.7581
Hs 633.T GDSC1 2.0202 3.5362 1.4672 8.3304
SK-LMS-1 GDSC1 2.0628 3.414 1.5665 7.3781
SK-UT-1 GDSC1 2.1133 4.3939 1.1284 10.5922
G-402 GDSC1 2.2372 6.3808 0.2438 16.7369
SW872 GDSC1 2.4745 3.9057 1.6776 4.9377
SW982 GDSC1 2.5199 3.9356 1.6984 4.6237
RKN GDSC1 2.7161 5.706 0.9709 9.6521
KYM-1 GDSC1 2.7603 4.0051 1.8393 2.8238
TE 441.T GDSC1 2.7875 8.7045 -0.4661 19.3052
HT-1080 GDSC1 2.844 4.2702 1.7688 3.1349
Rh41 GDSC1 2.8575 4.7245 1.5593 4.6838
G-401 GDSC1 2.9267 6.2306 0.8714 9.7362
VA-ES-BJ GDSC1 2.9538 4.7732 1.6021 4.0984
MFH-ino GDSC1 3.3712 5.3649 1.5899 3.2057
SW684 GDSC1 4.0059 5.089 2.0059 0.2132
MES-SA GDSC1 4.4913 5.8101 1.9316 0.2109
GCT GDSC1 4.8058 6.2132 1.9052 0.1729
Rh30 GDSC1 4.8136 6.3901 1.8472 0.2873
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HGC-27 GDSC1 0.4521 2.7155 0.17 25.649
IM95 GDSC1 0.6834 3.4293 0.1565 24.4488
SNU-1 GDSC1 0.9042 3.1665 0.4948 20.9382
NUGC-4 GDSC1 0.9837 3.524 0.433 20.9567
RF-48 GDSC1 1.0603 4.0768 0.2701 21.7088
23132/87 GDSC1 1.1554 3.3286 0.6942 18.2118
TGBC11TKB GDSC1 1.8961 4.301 0.978 12.6444
Fu97 GDSC1 2.1579 7.1247 -0.1952 19.9694
MKN45 GDSC1 2.3931 3.3548 1.8873 3.566
RERF-GC-1B GDSC1 2.4123 8.7543 -0.7963 22.5109
GCIY GDSC1 2.453 4.3018 1.4628 6.7014
AGS GDSC1 2.667 5.6095 0.9807 9.7394
Hs 746.T GDSC1 2.9017 4.3018 1.7917 2.8199
TMK-1 GDSC1 2.9288 4.8742 1.5365 4.6602
MKN1 GDSC1 3.0873 6.4401 0.8868 9.1313
NCI-N87 GDSC1 3.299 5.5352 1.4669 4.2419
SNU-16 GDSC1 3.46 4.9359 1.8286 1.4838
NUGC-3 GDSC1 3.5618 6.8953 0.9956 7.0253
ECC10 GDSC1 3.7409 6.7055 1.1986 5.1488
MKN7 GDSC1 3.7918 7.8975 0.6712 8.7506
MKN28 GDSC1 3.9261 9.0134 0.2276 11.4206
SCH GDSC1 4.1914 5.361 1.9788 0.2084
HSC-39 GDSC1 4.2384 6.1247 1.7144 1.1358
SNU-5 GDSC1 4.4078 5.7723 1.9144 0.2801
OCUM-1 GDSC1 4.5611 6.5132 1.7039 0.8915
SNG-M GDSC1 2.4952 5.8931 0.7022 12.4492
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HTC-C3 GDSC1 1.8158 3.7221 1.1834 11.4095
TT2609-C02 GDSC1 1.9218 4.5412 0.8834 13.2636
BHT-101 GDSC1 2.2105 3.7851 1.5169 7.1654
8505C GDSC1 2.2907 4.7126 1.1229 9.9554
K5 GDSC1 2.3008 4.2293 1.3731 7.9544
CGTH-W-1 GDSC1 2.4241 4.733 1.2239 8.6804
ML-1 [Human leukemia] GDSC1 2.4345 5.626 0.786 12.0324
CAL-62 GDSC1 2.7466 4.3971 1.6399 4.3819
TT GDSC1 2.7691 4.0618 1.8181 2.9603
B-CPAP GDSC1 2.8263 6.6171 0.6037 12.0507
8305C GDSC1 3.0062 5.7262 1.1774 7.1759
FTC-133 GDSC1 4.1378 5.3757 1.9538 0.2919
WRO GDSC1 4.3262 6.0931 1.7648 0.8321
IHH-4 GDSC1 4.4765 5.7375 1.9513 0.1761
ASH-3 GDSC1 4.5248 5.9546 1.8936 0.2853
KMH-2 GDSC1 5.1932 6.7375 1.8628 0.1538
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-9 GDSC1 1.3887 3.4743 0.873 15.7416
SCC-25 GDSC1 1.4914 3.7074 0.8717 15.2574
BB49-HNC GDSC1 1.9311 4.038 1.1392 11.2523
NCI-H3118 GDSC1 2.0106 5.0162 0.7282 14.0848
PCI-06A GDSC1 2.0628 3.764 1.3949 8.7144
PCI-38 GDSC1 2.1246 4.0716 1.2985 9.2177
BHY GDSC1 2.3039 3.9548 1.5128 6.8424
BB30-HNC GDSC1 2.3699 4.4879 1.3017 8.2638
JHU-022 GDSC1 2.4742 4.7799 1.2412 8.3692
HO-1-u-1 GDSC1 2.5619 4.9351 1.2339 8.1267
OSC-19 GDSC1 2.5998 4.2285 1.6145 5.0243
LB771-HNC GDSC1 2.6516 5.1461 1.1991 8.1
CAL-33 GDSC1 2.6914 4.2616 1.6663 4.3397
JHU-011 GDSC1 2.7723 5.5106 1.1108 8.3955
Detroit 562 GDSC1 2.7802 4.4963 1.6155 4.4722
SKN-3 GDSC1 2.8548 5.4603 1.1975 7.4711
HSC-3 GDSC1 2.9426 4.2984 1.8194 2.5211
CAL-27 GDSC1 2.9431 4.8476 1.5591 4.4506
Ca9-22 GDSC1 2.9484 6.6976 0.657 11.2644
KOSC-2 GDSC1 3.0743 5.4645 1.3521 5.6602
FaDu GDSC1 3.1009 4.5732 1.7896 2.3828
SCC-15 GDSC1 3.1041 5.8199 1.2011 6.7182
SAS GDSC1 3.2317 5.3478 1.5118 4.0742
PE/CA-PJ15 GDSC1 3.2503 5.685 1.3649 5.1059
OSC-20 GDSC1 3.294 6.0145 1.2371 5.9396
HO-1-N-1 GDSC1 3.4059 5.7511 1.4333 4.2363
HSC-2 GDSC1 3.4716 4.7799 1.8994 1.0634
BICR 78 GDSC1 3.4896 5.7515 1.4843 3.6921
SCC-4 GDSC1 3.5028 6.5543 1.1185 6.2819
PCI-04B GDSC1 3.5254 6.4571 1.179 5.7876
BICR 31 GDSC1 3.6636 5.7017 1.6063 2.5336
PCI-30 GDSC1 4.0018 7.0617 1.1922 4.64
SAT [Human HNSCC] GDSC1 4.0739 6.6125 1.4315 2.9408
BICR 22 GDSC1 4.2309 5.5878 1.9134 0.3621
BICR 10 GDSC1 4.2432 5.7716 1.8513 0.5586
HSC-4 GDSC1 4.3294 5.9977 1.8021 0.6807
PCI-15A GDSC1 4.6039 6.7018 1.65 1.0826
KON GDSC1 5.1147 6.75 1.8312 0.2257
DOK GDSC1 5.4323 7.9264 1.5322 0.9132
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 GDSC1 0.9134 3.2755 0.4614 21.1245
SW1710 GDSC1 1.0221 3.0332 0.6722 19.0624
RT-4 GDSC1 1.8023 4.5061 0.7907 14.4735
CAL-29 GDSC1 2.141 4.4817 1.1091 10.6338
5637 GDSC1 2.4343 4.9052 1.1461 9.2531
TCCSUP GDSC1 2.7881 4.5451 1.5975 4.5883
HT-1197 GDSC1 2.8956 4.5766 1.6569 3.8397
J82 GDSC1 2.9175 4.7244 1.6008 4.2043
639V GDSC1 2.9247 4.6278 1.6521 3.7996
BFTC-905 GDSC1 3.1903 5.0037 1.6461 3.202
647V GDSC1 3.4024 5.5633 1.5179 3.6439
T24 GDSC1 3.687 5.8039 1.5743 2.6985
KU-19-19 GDSC1 4.2786 5.5597 1.9413 0.2647
RT-112 GDSC1 4.294 10.2681 -0.1246 12.6922
SW780 GDSC1 4.9664 6.3736 1.9068 0.1348
HT-1376 GDSC1 5.2405 6.8901 1.8277 0.1992
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
C-33 A GDSC1 0.7456 3.4264 0.2233 23.662
Ca Ski GDSC1 0.9089 3.7965 0.239 22.6935
OVMIU GDSC1 1.3794 5.7873 -0.2286 23.4764
NEC8 GDSC1 1.5099 3.3572 1.0486 13.8495
ME-180 GDSC1 1.5432 3.9812 0.7959 15.5833
SW962 GDSC1 1.5876 4.6845 0.5026 17.5587
KGN GDSC1 1.5906 5.2165 0.2468 19.3765
PA-1 GDSC1 1.6101 4.73 0.5018 17.4637
SW954 GDSC1 1.6148 4.8404 0.4527 17.8012
ACC-OV7 GDSC1 1.7096 3.5258 1.1726 11.9725
SKN GDSC1 1.7534 3.684 1.1412 12.0117
UWB1.289 GDSC1 1.9548 4.7948 0.7881 13.8558
OV17R GDSC1 2.1056 4.6614 0.9886 11.7098
OVCA420 GDSC1 2.1477 3.4759 1.6143 6.6516
JHOS-3 GDSC1 2.1666 4.7511 0.9973 11.4042
DSH1 GDSC1 2.1918 4.9632 0.9132 11.958
NT2-D1 GDSC1 2.658 6.3016 0.629 12.4289
DoTc2 4510 GDSC1 2.6659 5.267 1.1502 8.4336
OMC-1 [Human cervical carcinoma] GDSC1 2.763 5.1063 1.3037 6.933
OVCA433 GDSC1 2.7634 4.945 1.3834 6.3141
BPH-1 GDSC1 2.7886 8.177 -0.2022 17.6955
JAR GDSC1 2.8286 4.5807 1.6088 4.3869
SiSo GDSC1 2.994 7.9798 0.0566 15.3297
HEY GDSC1 2.9944 6.0453 1.0127 8.4616
HeLa GDSC1 3.0103 4.7067 1.6711 3.4422
HT-3 GDSC1 3.0284 7.0599 0.5383 11.8767
SiHa GDSC1 3.0696 4.6448 1.7377 2.8186
HEC-1 GDSC1 3.0775 4.4679 1.8237 2.1949
LB831-BLC GDSC1 3.1707 5.3948 1.4503 4.6748
C-4-I GDSC1 3.553 5.8501 1.4771 3.6091
PEO1 GDSC1 4.0032 5.9391 1.68 1.5794
MS751 GDSC1 4.1631 6.5537 1.5033 2.3639
SKG-IIIa GDSC1 4.2028 6.2717 1.6395 1.5488
JEG-3 GDSC1 4.3617 6.0411 1.7991 0.6688
CAL-39 GDSC1 4.6988 7.3294 1.4446 1.9755
SW756 GDSC1 4.818 6.5639 1.7876 0.4384
NCC-IT GDSC1 5.2884 6.6961 1.9088 0.082
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948.
2 PIKfyve negatively regulates exocytosis in neurosecretory cells. J Biol Chem. 2008 Feb 1;283(5):2804-13.