Details of the Drug

General Information of Drug (ID: DMUA0XC)

Drug Name
ALF-5755
Synonyms HIP/PAP; Hepatocarcinoma-intestine-pancreas/pancreatic-associated protein
Indication
Disease Entry ICD 11 Status REF
Liver failure DB99.7 Phase 2 [1]
Cross-matching ID
TTD ID
D01FBS

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Regenerating human pro-islet peptide (REG3A) TTL4H8N REG3A_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification 13 Disease of the digestive system
Disease Class ICD-11: DD91 Irritable bowel syndrome
The Studied Tissue Liver tissue
The Studied Disease Liver failure [ICD-11:DD91.0]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Regenerating human pro-islet peptide (REG3A) DTT REG3A 1.68E-02 -0.13 -0.87
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT01318525) Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure. U.S. National Institutes of Health.
2 HIP/PAP prevents excitotoxic neuronal death and promotes plasticity. Ann Clin Transl Neurol. 2014 October; 1(10): 739-754.