Details of the Drug

General Information of Drug (ID: DMUANF9)

Drug Name

PHE-377

Synonyms

V 377; 2-(Diisopropylamino)-2',6'-acetoxylidide, hydrochloride; 2',6'-ACETOXYLIDIDE, 2-(DIISOPROPYLAMINO)-, HYDROCHLORIDE; AC1Q1RXG; AC1L1G06; LS-13907; 77966-84-8; [2-(2,6-dimethylanilino)-2-oxoethyl]-di(propan-2-yl)azanium chloride; [2-[(2,6-dimethylphenyl)amino]-2-oxoethyl]-di(propan-2-yl)azanium chloride

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Phase 1	[1]

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski):
0

Molecular Weight

298.8

Logarithm of the Partition Coefficient

Not Available

Rotatable Bond Count

5

Hydrogen Bond Donor Count

2

Hydrogen Bond Acceptor Count

2

Chemical Identifiers

Formula: C16H27ClN2O
IUPAC Name: [2-(2,6-dimethylanilino)-2-oxoethyl]-di(propan-2-yl)azanium;chloride
Canonical SMILES: CC1=C(C(=CC=C1)C)NC(=O)C[NH+](C(C)C)C(C)C.[Cl-]
InChI: InChI=1S/C16H26N2O.ClH/c1-11(2)18(12(3)4)10-15(19)17-16-13(5)8-7-9-14(16)6;/h7-9,11-12H,10H2,1-6H3,(H,17,19);1H
InChIKey: OJTPHJHZGWBMET-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 53956
CAS Number: 77966-84-8
TTD ID: D0EK1C

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transient receptor potential cation channel V1 (TRPV1)	TTMI6F5	TRPV1_HUMAN	Antagonist	[2]

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031648)
2	Clinical pipeline report, company report or official report of Pharmeste.