Details of the Drug

General Information of Drug (ID: DMUCQYW)

Drug Name
LMP744
Synonyms
LMP-744; 308246-52-8; MJ-III-65; LMP744 free base; UNII-29BY7HQV0T; NSC-706744; 29BY7HQV0T; NCI60_037977; CHEMBL126159; 308246-52-8 (free base); 6-(3-((2-hydroxyethyl)amino)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione; AC1L9FIC; SCHEMBL4162998; DTXSID30327954; BCP34017; EX-A3021; BDBM50237809; HY-U00248; NSC706743; CS-7432; NSC-706743; Q27894415; 20-[3-(2-Hydroxyethylamino)propyl]-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione; 5H-(1,3)Dioxolo(5,6)indeno(1,2-C)isoquinoline-5,12(6H)-dione, 6-(3-((2-hydroxyethyl)amino)propyl)-2,3-dimethoxy-; 5H-[1,6]indeno[1,2-c]isoquinoline- 5,12(6H)-dione,6-[3-[(2-hydroxyethyl)amino]propyl]-2,3-dimethoxy-; 6-[3-(2-Hydroxyethyl)aminopropyl]-5,11-diketo-2,3-dimethoxy-8,9-(methylenedioxy)- 11H-indeno[1,2-c]isoquinoline
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 452.5
Logarithm of the Partition Coefficient (xlogp) 1.4
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C24H24N2O7
IUPAC Name
20-[3-(2-hydroxyethylamino)propyl]-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione
Canonical SMILES
COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCNCCO)OC
InChI
InChI=1S/C24H24N2O7/c1-30-17-8-13-16(11-18(17)31-2)24(29)26(6-3-4-25-5-7-27)22-14-9-19-20(33-12-32-19)10-15(14)23(28)21(13)22/h8-11,25,27H,3-7,12H2,1-2H3
InChIKey
QCSDJDQOJBQTDV-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
397888
CAS Number
308246-52-8
TTD ID
DDXH71

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase I (TOP1) TTGTQHC TOP1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
DNA topoisomerase I (TOP1) DTT TOP1 6.65E-01 0.2 0.39
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 -0.9859 1.9603 -1.3316 27.5907
EW-22 GDSC2 -7.098 -4.519 -7.0994 83.7341
ES7 GDSC2 -6.4219 -3.933 -6.4239 78.5019
EW-3 GDSC2 -6.3025 1.1403 -6.9057 67.6008
ES8 GDSC2 -6.0662 -3.9119 -6.067 75.8964
A-673 GDSC2 -6.06 -3.19 -6.0675 74.7055
SK-ES-1 GDSC2 -6.003 -4.3611 -6.0031 75.8411
SK-PN-DW GDSC2 -4.8873 -3.1674 -4.8877 64.8617
TC-71 GDSC2 -4.8172 -3.1911 -4.8175 64.1879
HuO9 GDSC2 -4.6222 -0.1093 -4.8131 60.2023
MHH-ES-1 GDSC2 -4.2542 -0.759 -4.3332 57.8472
EW-16 GDSC2 -4.2094 -2.4119 -4.2108 58.1041
EW-1 GDSC2 -4.1474 -1.7491 -4.1588 57.3577
CADO-ES1 GDSC2 -3.9148 -1.8826 -3.9196 55.1406
EW-24 GDSC2 -3.8017 0.9805 -4.1403 53.306
EW-7 GDSC2 -3.7746 0.5976 -4.0272 53.2094
EW-11 GDSC2 -2.9678 1.9068 -3.4751 46.5169
NY GDSC2 -2.4432 0.6542 -2.5964 41.0043
SaOS-2 GDSC2 -2.2075 1.0749 -2.4266 38.9589
ES4 GDSC2 -1.6992 3.8656 -2.804 37.3445
ES5 GDSC2 -1.5618 2.8397 -2.2583 34.7173
HOS GDSC2 -1.4097 1.5135 -1.6639 31.3173
MG-63 GDSC2 -1.1761 1.6781 -1.4542 29.1269
HuO-3N1 GDSC2 -0.7239 3.0049 -1.4268 26.873
EW-18 GDSC2 -0.6747 1.1742 -0.7823 23.2324
ES6 GDSC2 -0.6557 4.2992 -1.9054 28.8889
CAL-78 GDSC2 -0.6028 4.8774 -2.1127 29.5768
CAL-72 GDSC2 0.1094 2.6564 -0.4061 17.6714
EW-13 GDSC2 0.5296 12.0558 -4.554 33.2043
H-EMC-SS GDSC2 0.8312 6.1801 -1.3675 20.4575
U2OS GDSC2 1.2006 2.9984 0.537 7.8443
NOS-1 [Human HNSCC] GDSC2 2.0483 4.2259 0.6279 4.8383
CHSA8926 GDSC2 2.8615 11.0323 -2.1216 18.2355
G-292 clone A141B1 GDSC2 3.3382 8.7604 -0.6677 9.6853
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-220 GDSC2 -3.0091 -0.8314 -3.0282 46.1543
ESO-26 GDSC2 -2.5851 0.2243 -2.6795 42.192
OACM5.1 C GDSC2 -1.4399 3.4427 -2.3596 34.4833
FLO-1 GDSC2 -0.947 2.8535 -1.6048 28.7864
OACP4 C GDSC2 -0.2723 1.7915 -0.5018 19.8578
ESO-51 GDSC2 0.5072 1.7537 0.3587 11.6094
TE-12 GDSC2 0.8132 2.8316 0.2415 11.0525
SK-GT-4 GDSC2 1.5163 5.4521 -0.4061 12.7358
KYAE-1 GDSC2 1.7103 3.1522 0.9032 3.9655
KYSE-50 GDSC2 2.8823 4.7673 0.9006 1.715
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 -0.8483 3.7335 -1.8577 29.5322
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC2 -4.8455 -2.8903 -4.8468 64.3702
Kelly GDSC2 -4.8432 -1.5162 -4.886 63.3203
SiMa GDSC2 -4.7577 -2.2709 -4.766 63.2376
IMR-5 GDSC2 -4.717 -3.0849 -4.7173 63.1884
SJNB-10 GDSC2 -4.3936 -0.501 -4.5109 58.8128
SJNB-13 GDSC2 -4.2493 -1.9171 -4.258 58.3757
NB(TU)1 GDSC2 -4.0801 0.0241 -4.2519 55.9439
CHP-134 GDSC2 -3.8408 -0.0324 -3.986 53.9682
SJNB-14 GDSC2 -3.8072 0.0246 -3.9588 53.6606
TGW GDSC2 -3.1805 0.8084 -3.4262 48.0859
SK-N-DZ GDSC2 -2.6336 1.6609 -3.0398 43.4673
NH-12 GDSC2 -2.0994 1.0847 -2.3112 37.8849
CHP-212 GDSC2 -1.5543 6.6985 -3.8994 39.403
SK-N-BE(2)-M17 GDSC2 -0.4653 1.8328 -0.7248 21.9518
KP-N-YN GDSC2 -0.0772 8.5551 -3.3666 32.046
GOTO GDSC2 0.7174 8.3586 -2.5495 26.3516
SK-N-AS GDSC2 1.6747 3.5962 0.6531 5.6445
SJNB-7 GDSC2 2.0721 6.1728 -0.3167 10.6271
GI-ME-N GDSC2 3.7337 6.6221 0.5514 2.3493
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 -0.2649 5.2952 -1.9715 27.5359
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 GDSC2 -5.0374 -2.8667 -5.0398 66.137
AU565 GDSC2 -2.1793 1.3258 -2.4553 38.8942
MDA-MB-468 GDSC2 -2.0937 0.5711 -2.2053 37.4203
CAL-85-1 GDSC2 -1.6666 0.4716 -1.7331 32.9593
CAL-51 GDSC2 -1.5944 1.4399 -1.8463 33.1252
HCC38 GDSC2 -1.5107 2.5814 -2.1098 33.85
HCC1806 GDSC2 -1.3022 1.0961 -1.4471 29.7076
Evsa-T GDSC2 -1.301 -0.001 -1.3099 29.0057
HCC2157 GDSC2 -1.2349 1.3415 -1.4295 29.2882
MDA-MB-231 GDSC2 -1.1675 1.4804 -1.391 28.7642
CAL-120 GDSC2 -0.6644 1.5601 -0.8631 23.6134
HCC1954 GDSC2 -0.4359 3.023 -1.1299 24.0413
OCUB-M GDSC2 -0.2334 1.7361 -0.4428 19.3584
T-47D GDSC2 -0.162 2.8998 -0.7914 21.0042
JIMT-1 GDSC2 -0.0639 1.4197 -0.1722 17.1113
MDA-MB-453 GDSC2 0.0546 2.2949 -0.3213 17.4134
HCC1143 GDSC2 0.3323 2.7321 -0.2048 15.5902
MDA-MB-415 GDSC2 0.3966 1.4299 0.3269 12.2876
HCC1500 GDSC2 0.4008 3.9575 -0.6905 18.1933
Hs 578T GDSC2 0.4031 2.6655 -0.1029 14.706
HCC1569 GDSC2 0.6981 1.7522 0.5668 9.6037
HDQ-P1 GDSC2 0.7042 1.8331 0.5461 9.6925
MDA-MB-436 GDSC2 0.761 5.0296 -0.8644 17.9068
BT-549 GDSC2 0.9474 4.5742 -0.4694 14.9291
MFM-223 GDSC2 1.3354 2.2815 1.0118 4.4262
COLO 824 GDSC2 1.422 3.6649 0.4062 7.9502
EFM-19 GDSC2 1.5891 4.3481 0.2068 8.7093
HCC1419 GDSC2 1.6789 4.6327 0.1386 8.8802
HCC70 GDSC2 1.8822 3.591 0.8176 4.0599
CAMA-1 GDSC2 1.9243 3.95 0.672 4.8656
MRK-nu-1 GDSC2 2.0889 6.5503 -0.4912 11.6341
MDA-MB-157 GDSC2 2.2918 4.2303 0.7948 3.282
HCC1937 GDSC2 2.3862 6.3118 -0.1485 8.811
BT-20 GDSC2 2.4226 5.0042 0.513 4.7024
MDA-MB-361 GDSC2 2.6356 4.8209 0.7361 2.9783
HCC1187 GDSC2 3.0382 5.0219 0.8732 1.6514
HCC1428 GDSC2 3.1495 4.6632 1.0728 0.6791
BT-474 GDSC2 3.3176 5.3046 0.8939 1.2461
MCF-7 GDSC2 3.5867 5.5802 0.9075 0.9509
EFM-192A GDSC2 3.7871 5.5913 0.9882 0.5455
MDA-MB-330 GDSC2 3.8873 6.2229 0.7889 1.1577
ZR-75-30 GDSC2 3.8998 5.7559 0.9726 0.5303
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H4 GDSC2 -5.5819 1.7848 -6.2919 63.5418
D283 Med GDSC2 -4.3711 -2.36 -4.3738 59.6686
8-MG-BA GDSC2 -3.5503 -0.4982 -3.6176 51.4502
SF539 GDSC2 -3.35 -0.9736 -3.3724 49.5326
Daoy GDSC2 -3.3317 0.4011 -3.5101 49.4062
GI-1 GDSC2 -2.8687 0.4181 -3.0138 45.0664
42-MG-BA GDSC2 -2.8294 0.7369 -3.0304 44.8138
AM-38 GDSC2 -2.796 -0.6612 -2.8172 44.039
U-118MG GDSC2 -2.5113 2.6086 -3.2016 43.0135
M059J GDSC2 -2.5077 -0.2103 -2.5486 41.2396
Becker GDSC2 -2.4605 1.397 -2.7801 41.6785
U-251MG GDSC2 -1.6101 1.7934 -1.961 33.7278
SF268 GDSC2 -1.4724 2.2666 -1.9598 33.009
U-87MG ATCC GDSC2 -1.3825 1.7341 -1.6955 31.3335
D-263MG GDSC2 -0.834 2.4308 -1.3261 26.8547
ONS-76 GDSC2 -0.4422 2.1771 -0.8133 22.3342
GB-1 GDSC2 -0.3198 4.4497 -1.6335 26.1633
KS-1 [Human Krukenberg tumour] GDSC2 -0.073 4.1548 -1.2514 23.186
T98G GDSC2 -0.0624 2.1743 -0.4023 18.3759
A-172 GDSC2 0.1421 2.8676 -0.4601 17.8513
SK-MG-1 GDSC2 0.3065 2.9855 -0.3411 16.4952
PFSK-1 GDSC2 0.3589 2.1358 0.0645 13.9148
KALS-1 GDSC2 0.5346 6.922 -2.0026 24.6363
GaMG GDSC2 0.5529 2.9627 -0.0798 13.9801
LN-18 GDSC2 0.7986 3.4937 -0.084 13.0927
YH-13 GDSC2 1.1768 6.721 -1.3306 19.1147
DBTRG-05MG GDSC2 1.4009 5.1303 -0.3433 12.7012
DK-MG GDSC2 1.8099 4.68 0.2207 8.0003
SW1088 GDSC2 2.0554 4.8347 0.3336 6.6528
LN-405 GDSC2 2.1417 4.4681 0.5769 4.9337
D-392MG GDSC2 2.516 7.0397 -0.4108 10.0693
CAS-1 GDSC2 2.6066 4.3539 0.9307 1.9497
LN-229 GDSC2 3.5267 5.8447 0.7732 1.5595
KINGS-1 GDSC2 4.0719 6.8239 0.6336 1.6165
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC2 -0.1963 2.3828 -0.6231 20.1995
TGBC24TKB GDSC2 4.0152 6.053 0.9089 0.6539
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESS-1 GDSC2 -5.2411 -3.8962 -5.2411 68.4637
AN3-CA GDSC2 0.7345 1.5392 0.6689 8.8783
MFE-280 GDSC2 1.6578 3.6281 0.6234 5.8794
RL95-2 GDSC2 2.1298 9.6718 -2.0139 19.675
MFE-319 GDSC2 2.2476 6.971 -0.5777 11.7304
EN GDSC2 3.0586 6.8754 0.0439 6.1883
MFE-296 GDSC2 3.2118 5.2597 0.8609 1.5049
KLE GDSC2 4.263 6.3886 0.8845 0.591
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 128 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DEL GDSC2 -6.9622 -5.1307 -6.9622 84.3695
SCC-3 GDSC2 -6.6317 -4.8424 -6.6318 81.5527
JVM-3 GDSC2 -6.525 -4.2613 -6.5258 79.8074
P32/ISH GDSC2 -6.4608 -5.0094 -6.4608 80.3871
DoHH2 GDSC2 -6.4557 -4.6725 -6.4558 79.9622
CML-T1 GDSC2 -6.3667 -4.9964 -6.3667 79.5527
MOLM-13 GDSC2 -6.3644 -3.7692 -6.3672 77.8098
SR GDSC2 -6.336 -0.7927 -6.5455 71.2451
SU-DHL-5 GDSC2 -6.1604 -5.2515 -6.1604 77.7056
P12-Ichikawa GDSC2 -6.0243 -4.6772 -6.0243 76.2295
MOLT-16 GDSC2 -5.8768 -5.0306 -5.8768 74.8734
Namalwa GDSC2 -5.8544 -3.1362 -5.8605 73.17
NALM-6 GDSC2 -5.7934 -5.0927 -5.7934 74.0415
SUP-M2 GDSC2 -5.7752 -3.2598 -5.7788 72.7544
BALL-1 GDSC2 -5.746 -4.8867 -5.746 73.5626
DND-41 GDSC2 -5.7268 -4.0214 -5.7269 73.1234
KOPN-8 GDSC2 -5.681 -3.4505 -5.6825 72.2327
JVM-2 GDSC2 -5.6225 -4.2183 -5.6225 72.2425
697 GDSC2 -5.6162 -4.6421 -5.6162 72.256
CESS GDSC2 -5.5848 -3.357 -5.5865 71.3319
MHH-CALL-2 GDSC2 -5.5387 -3.5635 -5.5394 71.1154
A3/Kawakami GDSC2 -5.518 -1.5962 -5.5835 68.3273
EB2 GDSC2 -5.4937 -4.4384 -5.4937 71.0228
SUP-T1 GDSC2 -5.4823 -1.18 -5.5855 67.4151
IM-9 GDSC2 -5.4816 -4.6631 -5.4816 70.912
WIL2 NS GDSC2 -5.48 -4.5156 -5.48 70.8912
LAMA-84 GDSC2 -5.4633 -3.8663 -5.4633 70.5993
KY821 GDSC2 -5.4249 -3.9126 -5.425 70.2516
DB GDSC2 -5.4193 -1.3291 -5.5038 67.2519
H9 GDSC2 -5.4068 -4.181 -5.4068 70.1363
P30/OHK GDSC2 -5.3895 -3.1747 -5.3915 69.4915
BC-1 GDSC2 -5.3707 -0.9901 -5.4889 66.4074
WSU-NHL GDSC2 -5.347 -3.6101 -5.3472 69.3947
SUP-HD1 GDSC2 -5.3451 -2.6211 -5.3543 68.5581
CCRF-CEM GDSC2 -5.3228 -4.0727 -5.3228 69.2935
VL51 GDSC2 -5.3174 -3.7328 -5.3175 69.1633
BL-41 GDSC2 -5.2644 -3.7893 -5.2644 68.6694
ARH-77 GDSC2 -5.2579 -3.6084 -5.2581 68.5533
RPMI-6666 GDSC2 -5.2451 -2.6798 -5.2518 67.8009
CTV-1 GDSC2 -5.2444 -3.6487 -5.2445 68.4371
HC-1 GDSC2 -5.1961 -3.7718 -5.1962 68.0015
ALL-SIL GDSC2 -5.188 -2.4983 -5.1977 67.1423
JSC-1 GDSC2 -5.1616 -1.275 -5.238 65.4231
MOLT-13 GDSC2 -5.1576 -3.1637 -5.1587 67.4099
Raji GDSC2 -5.1073 -3.5782 -5.1074 67.0946
JURL-MK1 GDSC2 -5.0989 -3.0527 -5.1003 66.8083
Daudi GDSC2 -5.09 -2.8994 -5.0925 66.6343
ML-2 GDSC2 -5.0623 -3.7578 -5.0623 66.6839
Reh GDSC2 -5.0438 -3.6201 -5.0439 66.483
PF-382 GDSC2 -5.0019 -1.9169 -5.0274 65.0117
GDM-1 GDSC2 -4.9113 -1.1334 -4.9882 63.426
Hs 445 GDSC2 -4.846 -3.1674 -4.8464 64.4625
SUP-B15 GDSC2 -4.8343 -3.2443 -4.8345 64.3646
GA-10 GDSC2 -4.8053 -1.2879 -4.8633 62.7846
KE-37 GDSC2 -4.7745 -3.4586 -4.7745 63.8031
VAL GDSC2 -4.7391 -2.5598 -4.7425 63.2292
SU-DHL-6 GDSC2 -4.7242 -3.2943 -4.7242 63.2894
SK-MM-2 GDSC2 -4.6376 -2.631 -4.6396 62.3035
OCI-AML-2 GDSC2 -4.5606 -3.2408 -4.5607 61.6612
HAL-01 GDSC2 -4.5121 -2.776 -4.5128 61.1294
A4/Fukuda GDSC2 -4.509 -2.8394 -4.5095 61.1091
L-540 GDSC2 -4.5044 -2.4017 -4.5077 60.9584
HEL GDSC2 -4.4679 -3.3744 -4.4679 60.7393
RS4;11 GDSC2 -4.4455 -2.2035 -4.4511 60.3301
SKM-1 GDSC2 -4.2136 -3.0874 -4.2136 58.1874
MLMA GDSC2 -4.205 0.115 -4.4017 56.885
Karpas-231 GDSC2 -4.1941 -3.3657 -4.1941 57.9937
Ku812 GDSC2 -4.1478 -2.0992 -4.1518 57.4498
EoL-1 GDSC2 -4.1373 -2.7411 -4.1375 57.4162
Karpas-422 GDSC2 -4.1251 -0.7112 -4.202 56.7145
RPMI-8866 GDSC2 -4.0921 -0.9776 -4.1429 56.5526
ALL-PO GDSC2 -4.076 -1.2744 -4.1057 56.528
SU-DHL-8 GDSC2 -4.0493 -3.3482 -4.0493 56.5406
Jurkat GDSC2 -3.9784 -2.2165 -3.98 55.8039
LC4-1 GDSC2 -3.9517 0.4781 -4.1951 54.6863
RPMI-8226 GDSC2 -3.9476 0.8518 -4.2697 54.4887
MM1.S GDSC2 -3.8995 -2.4708 -3.8998 55.0317
SU-DHL-10 GDSC2 -3.8981 -1.8296 -3.9036 54.9702
Jiyoye GDSC2 -3.765 -0.6281 -3.8308 53.4669
OPM-2 GDSC2 -3.5233 0.629 -3.7609 51.0931
Farage GDSC2 -3.49 3.8965 -4.7204 50.584
OCI-M1 GDSC2 -3.4242 -2.2754 -3.4242 50.267
TK [Human B-cell lymphoma] GDSC2 -3.3612 -1.6378 -3.3641 49.6369
BE-13 GDSC2 -3.3602 -0.3044 -3.4374 49.6452
GR-ST GDSC2 -3.3402 2.6838 -4.1257 49.5852
U-698-M GDSC2 -3.2802 0.105 -3.4059 48.9114
ST486 GDSC2 -3.2651 0.3527 -3.4298 48.7943
L-1236 GDSC2 -3.1869 -1.2794 -3.194 47.8994
Karpas-1106P GDSC2 -3.1791 1.3073 -3.5411 48.1599
Ramos.2G6.4C10 GDSC2 -3.1443 -0.4372 -3.1962 47.5464
OCI-AML-5 GDSC2 -3.1033 -0.6425 -3.1369 47.1162
NOMO-1 GDSC2 -3.0775 -1.1716 -3.0855 46.8095
Granta-519 GDSC2 -3.0467 -0.5523 -3.0845 46.5674
AMO1 GDSC2 -2.8883 0.9432 -3.1378 45.4514
NCI-H929 GDSC2 -2.6107 2.0064 -3.1156 43.4769
MEG-01 GDSC2 -2.4796 0.8389 -2.6717 41.481
OCI-AML-3 GDSC2 -2.4494 1.4548 -2.783 41.6152
MN-60 GDSC2 -2.3917 1.6841 -2.7824 41.2463
HL-60 GDSC2 -2.305 -1.2279 -2.3054 39.0381
RC-K8 GDSC2 -2.1068 1.8893 -2.531 38.7286
TUR GDSC2 -2.0417 -0.578 -2.0474 36.4221
KCL-22 GDSC2 -1.9822 0.7257 -2.1115 36.3937
ATN-1 GDSC2 -1.9583 -0.403 -1.9677 35.6034
Karpas-299 GDSC2 -1.9266 -0.1868 -1.9452 35.3302
KMS-12-BM GDSC2 -1.8708 -0.6226 -1.8734 34.6921
Loucy GDSC2 -1.7899 -0.0416 -1.8125 33.9795
DG-75 GDSC2 -1.7639 1.2176 -1.9764 34.6108
EM-2 GDSC2 -1.7166 0.0262 -1.7409 33.2524
MOLP-8 GDSC2 -1.6025 2.6167 -2.2214 34.7842
HDLM-2 GDSC2 -1.4899 2.5214 -2.0662 33.5597
KMOE-2 GDSC2 -1.3853 0.9452 -1.507 30.4209
KM-H2 GDSC2 -1.3532 1.4149 -1.5767 30.6082
KG-1 GDSC2 -1.2275 0.8971 -1.3276 28.7326
Kasumi-1 GDSC2 -1.1559 2.6579 -1.7552 30.5011
L-428 GDSC2 -1.0223 1.6459 -1.2773 27.4822
EJM GDSC2 -0.9991 1.0137 -1.1022 26.4604
CA46 GDSC2 -0.9882 2.2667 -1.435 28.1312
MOLT-4 GDSC2 -0.304 3.39 -1.1462 23.5678
L-363 GDSC2 -0.0337 2.2498 -0.3992 18.2343
MHH-PREB-1 GDSC2 0.2025 2.6 -0.285 16.586
ME1 GDSC2 0.2146 6.5429 -2.1118 26.2938
JJN-3 GDSC2 0.2782 1.9567 0.0425 14.3867
Karpas-45 GDSC2 0.5099 1.5626 0.4177 11.2729
Karpas-620 GDSC2 0.991 2.3963 0.6186 8.0971
U266B1 GDSC2 1.2684 7.8541 -1.8171 21.2993
LP-1 GDSC2 1.6083 3.1498 0.8219 4.7635
K-562 GDSC2 1.6459 4.1646 0.3455 7.6703
HH [Human lymphoma] GDSC2 2.1236 5.1406 0.2336 7.1051
⏷ Show the Full List of 128 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW13 GDSC2 -5.2304 -3.583 -5.2305 68.2815
ACHN GDSC2 -4.1622 -2.3511 -4.1638 57.6318
CAL-54 GDSC2 -3.1861 -0.4551 -3.2384 47.9536
786-O GDSC2 -2.9487 0.317 -3.0831 45.8043
LB996-RCC GDSC2 -2.7155 1.6132 -3.116 44.1823
KMRC-20 GDSC2 -1.239 2.1674 -1.6736 30.5174
BFTC-909 GDSC2 -0.9272 1.5796 -1.1552 26.3943
HA7-RCC GDSC2 -0.8862 1.7731 -1.1655 26.2555
KTCTL-195 GDSC2 -0.5354 2.557 -1.0518 24.0521
RXF 393L GDSC2 -0.3095 2.3735 -0.741 21.3497
NCC010 GDSC2 0.5419 2.0663 0.2867 11.8646
RCC10RGB GDSC2 0.574 1.4582 0.5135 10.4598
769-P GDSC2 1.0923 4.2884 -0.1964 12.7762
SN12C GDSC2 1.1883 5.1765 -0.5512 14.6312
TK-10 GDSC2 1.5171 4.7741 -0.0665 10.6362
OS-RC-2 GDSC2 1.734 4.8194 0.0902 9.0294
A-704 GDSC2 2.0439 5.0567 0.2152 7.4197
A-498 GDSC2 2.4606 4.2502 0.8921 2.3999
VMRC-RCZ GDSC2 2.5741 4.6569 0.7742 2.87
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-CO-1 GDSC2 -4.0595 -2.5722 -4.0598 56.6328
SNU-C5 GDSC2 -3.0545 -0.4175 -3.1038 46.6658
KM12 GDSC2 -2.3021 1.2598 -2.5729 40.0439
SW48 GDSC2 -2.2972 1.6661 -2.6742 40.3372
HT-29 GDSC2 -2.2169 0.6341 -2.3485 38.7169
HCT 15 GDSC2 -2.1929 0.7816 -2.3496 38.5803
HCT 116 GDSC2 -2.1071 -0.5777 -2.114 37.0843
SNU-175 GDSC2 -2.0187 1.8333 -2.4183 37.821
RKO GDSC2 -1.9934 0.292 -2.058 36.2159
HCC2998 GDSC2 -1.7224 1.5245 -2.0081 34.5291
RCM-1 [Human ESC] GDSC2 -1.4513 0.4886 -1.5062 30.7457
LS513 GDSC2 -1.1166 3.1078 -1.8842 30.9074
HT-55 GDSC2 -1.1146 -0.0649 -1.1179 27.1071
MDST8 GDSC2 -1.0836 2.3855 -1.5795 29.3069
SW620 GDSC2 -0.8907 3.7044 -1.8895 29.8714
LoVo GDSC2 -0.885 2.0047 -1.2359 26.6198
CaR-1 GDSC2 -0.5436 1.913 -0.8353 22.9089
SW948 GDSC2 -0.3124 2.365 -0.7409 21.362
NCI-H747 GDSC2 -0.2961 1.3941 -0.4191 19.5182
GP5d GDSC2 0.1606 4.2998 -1.0868 21.3686
DiFi GDSC2 0.2897 1.9636 0.0525 14.2803
SW1463 GDSC2 0.3007 2.9126 -0.3153 16.3666
C2BBe1 GDSC2 0.532 3.2642 -0.2381 15.0099
SW626 GDSC2 0.5323 4.7467 -0.9406 19.1557
LS411N GDSC2 0.6459 4.5925 -0.7586 17.6965
NCI-H716 GDSC2 0.726 1.6161 0.6388 9.0808
SW1417 GDSC2 0.8395 3.9952 -0.2865 14.1872
SNU-C2B GDSC2 0.9686 4.1161 -0.2249 13.3658
HT115 GDSC2 0.9922 2.7211 0.4701 8.9945
LS180 GDSC2 1.064 8.4649 -2.2983 24.1564
COLO205 GDSC2 1.2759 3.2394 0.4879 7.8997
CW-2 GDSC2 1.4494 4.4269 0.0495 10.1137
CCK-81 GDSC2 1.5034 3.3614 0.6279 6.3007
LS123 GDSC2 1.547 4.6136 0.0389 9.8881
SNU-C1 GDSC2 1.6005 4.9851 -0.1022 10.6135
SW1116 GDSC2 1.7708 5.0802 -0.0103 9.5546
SNU-1040 GDSC2 1.9438 3.9808 0.6714 4.8208
COLO 678 GDSC2 2.6379 6.917 -0.2626 8.9006
SNU-407 GDSC2 2.6661 7.2859 -0.4225 9.7805
T84 GDSC2 2.7064 4.755 0.8082 2.4573
CL-11 GDSC2 2.8351 9.0596 -1.1686 13.5812
SNU-81 GDSC2 2.9719 4.616 1.0099 1.093
SW837 GDSC2 3.1771 5.2504 0.8474 1.6074
COLO 320HSR GDSC2 3.4425 5.2062 0.9898 0.7594
LS1034 GDSC2 3.8493 5.3119 1.1126 0.2189
SNU-61 GDSC2 4.168 6.0501 0.9705 0.4114
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 2.1248 6.5916 -0.484 11.4956
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HLE GDSC2 -2.9095 -0.4437 -2.9497 45.2205
JHH-4 GDSC2 -2.3232 0.3639 -2.4195 39.6251
JHH-2 GDSC2 -2.0436 1.28 -2.296 37.5037
SNU-398 GDSC2 -1.8894 1.7356 -2.2489 36.4471
SK-HEP-1 GDSC2 -0.6847 2.9128 -1.3486 26.2941
SNU-423 GDSC2 -0.4682 3.2432 -1.2548 24.85
JHH-6 GDSC2 -0.0571 2.0578 -0.3554 18.0887
SNU-387 GDSC2 0.2744 1.4421 0.191 13.5868
Hep 3B2.1-7 GDSC2 0.3139 1.5336 0.2115 13.2923
HuH-1 GDSC2 0.3164 2.1086 0.029 14.2983
SNU-449 GDSC2 0.4525 1.7988 0.2847 12.264
Hep-G2/C3A GDSC2 2.051 8.1922 -1.3388 16.537
JHH-1 GDSC2 2.3089 4.9216 0.4747 5.1817
JHH-7 GDSC2 2.9341 5.2674 0.7094 2.6364
Huh-7 GDSC2 3.8793 5.4271 1.0833 0.2671
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 129 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H209 GDSC2 -6.784 -4.9974 -6.7841 82.9115
NCI-H1876 GDSC2 -5.6684 -2.6759 -5.6816 71.1049
NCI-H526 GDSC2 -5.3482 -4.1151 -5.3482 69.5497
HCC78 GDSC2 -5.2847 -3.5514 -5.2849 68.7839
DMS 79 GDSC2 -4.7682 -1.3404 -4.8205 62.5451
NCI-H1155 GDSC2 -4.7652 -1.2841 -4.8218 62.4651
NCI-H1694 GDSC2 -4.3868 -2.4754 -4.3886 59.8484
NCI-H1781 GDSC2 -4.3349 -1.2028 -4.3791 58.8157
NCI-H2795 GDSC2 -4.1869 1.1291 -4.5956 56.1072
IST-SL2 GDSC2 -4.1483 -2.2169 -4.1509 57.476
SBC-3 GDSC2 -4.0102 -0.1645 -4.1478 55.4618
COR-L311 GDSC2 -3.8692 -0.2151 -3.9899 54.2774
COLO 668 GDSC2 -3.8602 0.2798 -4.0588 54.0214
LOU-NH91 GDSC2 -3.5271 -0.4093 -3.6025 51.225
NCI-H2170 GDSC2 -3.5053 0.183 -3.6598 50.9757
NCI-H82 GDSC2 -3.4864 -0.0271 -3.6073 50.8193
EBC-1 GDSC2 -3.3411 -0.9445 -3.3647 49.4449
NCI-H1623 GDSC2 -3.2323 -1.1606 -3.2437 48.3588
NCI-H446 GDSC2 -3.1431 -1.4513 -3.1464 47.4547
Lu-139 GDSC2 -3.0229 0.6723 -3.2272 46.6124
Lu-135 GDSC2 -2.8895 -0.1055 -2.9616 45.1029
HARA [Human squamous cell lung carcinoma] GDSC2 -2.7861 -0.1583 -2.8464 44.0592
NCI-H2810 GDSC2 -2.7272 0.2584 -2.8365 43.6212
NCI-H1651 GDSC2 -2.6795 0.5213 -2.8277 43.2676
NCI-H2023 GDSC2 -2.5064 0.4758 -2.6335 41.5316
A-549 GDSC2 -2.5005 0.357 -2.6083 41.4087
NCI-H211 GDSC2 -2.3992 2.0768 -2.9067 41.6285
HOP-62 GDSC2 -2.3374 2.8408 -3.0941 41.7074
NCI-H3122 GDSC2 -2.3084 -0.2297 -2.3388 39.2088
DMS 53 GDSC2 -2.2876 0.7934 -2.4545 39.5427
NCI-H2122 GDSC2 -2.2759 1.3639 -2.5703 39.8746
NCI-H1792 GDSC2 -2.2599 0.4354 -2.3623 39.0242
NCI-H2804 GDSC2 -2.1447 1.9493 -2.5904 39.1501
NCI-H2228 GDSC2 -2.1327 1.2766 -2.3923 38.3888
NCI-H524 GDSC2 -2.0698 1.5264 -2.3877 38.0046
NCI-H1915 GDSC2 -1.9813 1.6418 -2.3227 37.251
SBC-5 GDSC2 -1.9784 0.311 -2.0444 36.0729
HCC366 GDSC2 -1.8966 0.5322 -1.9876 35.3724
NCI-H1048 GDSC2 -1.8113 3.9679 -2.9638 38.4054
EMC-BAC-2 GDSC2 -1.8102 2.4205 -2.378 36.5023
EPLC-272H GDSC2 -1.6726 1.1596 -1.8637 33.6132
Ms-1 GDSC2 -1.642 3.1329 -2.454 35.8749
NCI-H2087 GDSC2 -1.4573 2.1074 -1.8912 32.6251
RERF-LC-KJ GDSC2 -1.3585 0.4564 -1.404 29.7679
DMS 273 GDSC2 -1.3158 3.7865 -2.3684 33.8978
SW1271 GDSC2 -1.2269 2.3889 -1.7356 30.7535
NCI-H3255 GDSC2 -1.1822 3.9562 -2.2996 32.9821
LCLC-97TM1 GDSC2 -1.1299 1.6594 -1.3985 28.6206
Calu-3 GDSC2 -1.0648 2.5077 -1.6025 29.3305
NCI-H2029 GDSC2 -1.0445 1.3486 -1.2237 27.3099
NCI-H2461 GDSC2 -1.0315 4.0707 -2.1917 31.8336
NCI-H322M GDSC2 -1.0214 1.9024 -1.3521 27.8641
NCI-H1963 GDSC2 -0.9833 1.0569 -1.0934 26.3386
NCI-H650 GDSC2 -0.9516 2.8706 -1.6163 28.8639
Calu-6 GDSC2 -0.9369 1.5361 -1.1541 26.4342
PC-14 GDSC2 -0.9255 1.7876 -1.2127 26.6876
LXF 289 GDSC2 -0.9159 1.5246 -1.1281 26.1987
LCLC-103H GDSC2 -0.8742 1.3802 -1.0458 25.5682
HCC44 GDSC2 -0.759 0.9543 -0.8326 23.8991
SK-LU-1 GDSC2 -0.5922 6.0425 -2.6434 31.6403
NCI-H250 GDSC2 -0.5822 1.1825 -0.6836 22.2721
NCI-H1944 GDSC2 -0.5088 3.0341 -1.2112 24.7939
NCI-H1568 GDSC2 -0.5016 3.4086 -1.3593 25.544
SK-MES-1 GDSC2 -0.4734 1.7041 -0.6951 21.8269
NCI-H1975 GDSC2 -0.4365 1.5658 -0.6159 21.2283
NCI-H358 GDSC2 -0.4294 2.8907 -1.0693 23.6842
COR-L23 GDSC2 -0.2897 1.9755 -0.5795 20.3643
NCI-H1755 GDSC2 -0.2595 1.6673 -0.451 19.5214
ABC-1 GDSC2 -0.2331 2.7994 -0.8252 21.4941
NCI-H23 GDSC2 -0.2258 7.4213 -2.952 31.2602
NCI-H1092 GDSC2 -0.2148 1.3313 -0.3161 18.5874
NCI-H1581 GDSC2 -0.1839 2.2937 -0.5767 19.8845
Lu-65 GDSC2 -0.1518 2.4527 -0.602 19.8894
NCI-H2731 GDSC2 -0.1505 3.0065 -0.8237 21.1388
SW1573 GDSC2 0.0729 4.738 -1.3787 23.2844
NCI-H2373 GDSC2 0.1735 5.2705 -1.5347 23.7031
NCI-H596 GDSC2 0.2304 2.3033 -0.1369 15.6132
CPC-N GDSC2 0.3962 2.8304 -0.1811 15.1955
NCI-H520 GDSC2 0.4183 1.9818 0.1849 12.9742
Lu-99A GDSC2 0.426 5.2864 -1.3024 21.5448
KNS-62 GDSC2 0.4368 2.1259 0.1516 13.0848
NCI-H1993 GDSC2 0.467 2.8384 -0.112 14.5059
NCI-H1299 GDSC2 0.5161 7.1227 -2.1184 25.2256
NCI-H441 GDSC2 0.5753 6.7604 -1.8858 23.9489
RERF-LC-Sq1 GDSC2 0.6443 3.3584 -0.1704 14.1815
NCI-H522 GDSC2 0.6679 3.9403 -0.4232 15.6241
SHP-77 GDSC2 0.8232 1.6309 0.7406 8.0822
NCI-H810 GDSC2 0.888 6.7541 -1.6012 21.4755
NCI-H2085 GDSC2 0.9227 2.5217 0.4929 9.1161
NCI-H513 GDSC2 0.9232 4.7368 -0.5716 15.6267
NCI-H2591 GDSC2 0.9447 6.4505 -1.4 20.2458
NCI-H2803 GDSC2 0.9582 5.7513 -1.0411 18.2427
NCI-H1666 GDSC2 1.2971 4.6101 -0.1737 11.9763
NCI-H1793 GDSC2 1.4234 4.2378 0.1217 9.7392
NCI-H1650 GDSC2 1.5346 4.1017 0.2844 8.3798
NCI-H2135 GDSC2 1.7159 4.6003 0.185 8.4847
NCI-H1693 GDSC2 1.7724 3.9202 0.5697 5.9033
Lu-165 GDSC2 1.7741 5.7656 -0.3499 11.6434
NCI-H2869 GDSC2 1.8076 5.2328 -0.0569 9.7435
NCI-H2227 GDSC2 1.844 12.3467 -3.5816 26.6254
HOP-92 GDSC2 1.8491 7.3225 -1.0668 15.6289
NCI-H2405 GDSC2 1.8625 6.1941 -0.4926 12.2594
HCC15 GDSC2 1.9499 8.4162 -1.5315 17.8261
IA-LM GDSC2 1.963 4.7908 0.2851 7.19
NCI-H2595 GDSC2 2.0631 6.4973 -0.485 11.6659
COR-L105 GDSC2 2.0968 6.9353 -0.6765 12.709
NCI-H226 GDSC2 2.1669 3.8224 0.9062 2.871
NCI-H2141 GDSC2 2.2385 6.0126 -0.1106 8.9429
HCC827 GDSC2 2.2596 5.8119 0.004 8.1888
NCI-H841 GDSC2 2.3068 6.1513 -0.1281 8.8806
NCI-H1563 GDSC2 2.3517 4.7672 0.5786 4.4566
NCI-H2369 GDSC2 2.3532 4.1338 0.8797 2.6636
NCI-H345 GDSC2 2.3711 3.4421 1.2008 0.8891
NCI-H2722 GDSC2 2.3876 6.6221 -0.3 9.7218
EKVX GDSC2 2.4387 5.9514 0.0659 7.3834
NCI-H2818 GDSC2 2.5368 5.9222 0.1492 6.6545
LC-1/sq GDSC2 2.6778 7.0399 -0.2941 8.9955
A-427 GDSC2 2.8132 6.9023 -0.1328 7.7353
NCI-H720 GDSC2 3.1562 4.7712 1.0334 0.8222
DMS 114 GDSC2 3.298 9.367 -0.9874 11.5279
NCI-H1869 GDSC2 3.3587 5.466 0.8476 1.4062
NCI-H727 GDSC2 3.7113 5.8482 0.8577 1.039
NCI-H196 GDSC2 3.7973 5.3596 1.0765 0.3109
NCI-H1435 GDSC2 3.8256 5.3986 1.0733 0.3074
LK-2 GDSC2 3.9086 5.5971 1.0338 0.3661
UMC-11 GDSC2 3.9263 5.7313 0.9921 0.4636
NCI-H661 GDSC2 3.99 6.0821 0.8877 0.7352
VMRC-LCD GDSC2 4.215 5.8722 1.0507 0.2281
NCI-H1355 GDSC2 4.7905 7.1065 0.8295 0.4936
⏷ Show the Full List of 129 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 -2.8976 1.0636 -3.1751 45.5846
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE33 GDSC2 -3.7478 -1.6021 -3.7561 53.4714
TE-15 GDSC2 -3.4125 -1.4804 -3.4185 50.149
KYSE-510 GDSC2 -3.0217 -1.6146 -3.0227 46.2316
KYSE-180 GDSC2 -1.6477 1.208 -1.8476 33.4089
KYSE-270 GDSC2 -1.4827 0.6011 -1.5546 31.145
TE-5 GDSC2 -1.1891 1.5257 -1.4264 29.0489
KYSE-410 GDSC2 -1.0562 0.9489 -1.1521 26.9951
TE-8 GDSC2 -0.9538 4.905 -2.4791 32.6069
EC-GI-10 GDSC2 -0.9128 3.2408 -1.7211 29.1894
KYSE-450 GDSC2 -0.7107 2.6585 -1.2778 26.0412
TE-9 GDSC2 -0.4234 4.1725 -1.6126 26.4951
KYSE-140 GDSC2 -0.0474 2.894 -0.6688 19.831
TE-6 GDSC2 0.0937 3.3627 -0.7253 19.5828
OE21 GDSC2 0.1798 2.5502 -0.2886 16.7007
COLO 680N GDSC2 0.4125 3.6173 -0.52 17.1444
TE-4 GDSC2 0.8284 3.2341 0.0682 12.0531
TE-1 GDSC2 1.0289 5.4064 -0.8069 16.6655
OE19 GDSC2 1.3278 5.0801 -0.3813 13.1592
KYSE-520 GDSC2 2.2351 4.3818 0.6843 4.0665
KYSE-70 GDSC2 2.9818 5.5435 0.613 3.085
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2780 GDSC2 -4.1412 1.4534 -4.6287 55.5974
TOV-112D GDSC2 -3.8275 -1.139 -3.8565 54.1675
ES-2 GDSC2 -3.1556 -0.5093 -3.2018 47.6493
DOV13 GDSC2 -2.8517 -0.94 -2.8622 44.5602
TYK-nu GDSC2 -2.7085 4.2594 -4.0289 45.4746
OVCAR-8 GDSC2 -2.1245 1.258 -2.3789 38.2908
OVTOKO GDSC2 -1.8673 -0.1942 -1.8835 34.7237
IGROV-1 GDSC2 -1.5839 3.2521 -2.4378 35.5126
OAW42 GDSC2 -1.133 1.6615 -1.4025 28.6557
EFO-27 GDSC2 -0.8027 3.821 -1.8477 29.2793
TOV-21G GDSC2 -0.5021 2.6541 -1.0533 23.9136
OVCAR-5 GDSC2 -0.003 1.9438 -0.2577 17.3043
OVCAR-3 GDSC2 0.8871 3.3818 0.0547 11.9252
OAW28 GDSC2 1.153 4.0403 -0.019 11.4758
OV56 GDSC2 1.4332 3.5985 0.4491 7.6448
OV-90 GDSC2 1.7065 6.6295 -0.8367 14.735
OVCAR-4 GDSC2 1.7761 5.1218 -0.0268 9.6428
EFO-21 GDSC2 1.7966 5.0013 0.0498 9.1081
Kuramochi GDSC2 1.9205 5.1415 0.078 8.5963
SK-OV-3 GDSC2 2.1316 6.4411 -0.404 10.9983
OVK18 GDSC2 2.7642 7.7629 -0.5849 10.4966
OVISE GDSC2 3.4309 4.7124 1.1685 0.242
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CFPAC-1 GDSC2 -2.8716 0.0611 -2.9631 44.9746
KP-4 GDSC2 -2.243 1.0028 -2.4492 39.2539
Panc 02.03 GDSC2 -1.9135 -0.1189 -1.9358 35.217
PSN1 GDSC2 -1.738 2.7512 -2.4156 36.2473
Capan-1 GDSC2 -1.6717 1.0067 -1.8296 33.4489
DAN-G GDSC2 -1.5835 0.1006 -1.6077 31.9173
PL4 GDSC2 -1.5297 1.43 -1.7731 32.4488
Panc 10.05 GDSC2 -1.4986 1.6606 -1.8011 32.4214
HuP-T4 GDSC2 -0.4584 2.5159 -0.9539 23.1785
HPAF-II GDSC2 -0.1747 2.2893 -0.5652 19.7799
MIA PaCa-2 GDSC2 -0.0632 1.8363 -0.2881 17.7408
YAPC GDSC2 0.1043 5.2101 -1.5723 24.1589
KP-1N GDSC2 0.2759 2.7233 -0.2597 16.1396
SUIT-2 GDSC2 0.2958 6.3641 -1.9488 25.2545
PaTu 8902 GDSC2 0.3312 2.0044 0.083 13.9279
QGP-1 GDSC2 0.8563 2.8335 0.2835 10.6361
HPAC GDSC2 1.3321 4.3448 -0.011 10.8532
PaTu 8988t GDSC2 1.4786 5.6009 -0.5123 13.4933
Panc 08.13 GDSC2 1.5814 3.3992 0.6749 5.7724
BxPC-3 GDSC2 1.6113 4.333 0.2328 8.4809
SU.86.86 GDSC2 1.78 3.6051 0.7325 4.8566
HuP-T3 GDSC2 1.888 4.3722 0.4351 6.444
KP-2 GDSC2 2.383 4.0835 0.9215 2.3685
AsPC-1 GDSC2 2.4701 4.6911 0.693 3.5326
Capan-2 GDSC2 2.5719 5.5649 0.3452 5.3968
KP-3 GDSC2 3.2425 5.9368 0.5858 2.8313
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2 -2.2749 2.0647 -2.7675 40.4786
MPP 89 GDSC2 0.6006 1.7536 0.4604 10.6286
NCI-H28 GDSC2 1.6065 4.9448 -0.0771 10.4396
IST-Mes1 GDSC2 2.5126 7.4008 -0.5907 11.1356
NCI-H2052 GDSC2 3.3101 8.1623 -0.4009 8.2428
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 GDSC2 -3.0312 1.8318 -3.5223 47.0263
LNCaP clone FGC GDSC2 -2.6764 2.1857 -3.2425 44.159
PC-3 GDSC2 -1.1025 1.9862 -1.4665 28.8337
DU145 GDSC2 -0.6357 1.4457 -0.802 23.1528
VCaP GDSC2 1.2927 6.7165 -1.2282 18.1923
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 -1.3642 1.4051 -1.5862 30.7098
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-375 GDSC2 -3.9878 -1.4669 -4.0055 55.765
RPMI-7951 GDSC2 -3.678 -0.6337 -3.7388 52.6635
UACC-62 GDSC2 -3.2853 0.4158 -3.4626 48.9845
LOX-IMVI GDSC2 -3.1958 -0.6833 -3.2302 48.0269
G-mel GDSC2 -2.1802 0.5161 -2.2893 38.265
WM1552C GDSC2 -1.8654 0.0522 -1.8982 34.7859
A2058 GDSC2 -1.8 2.4392 -2.3732 36.4284
IGR-37 GDSC2 -1.4229 0.7254 -1.5092 30.619
WM793 GDSC2 -1.2877 1.8947 -1.6398 30.5935
WT2-iPS GDSC2 -0.8289 3.2466 -1.635 28.3892
HT-144 GDSC2 -0.7359 3.189 -1.5135 27.3668
A101D GDSC2 -0.6661 2.4096 -1.1376 25.0969
COLO 679 GDSC2 -0.3231 4.0964 -1.4767 25.3902
WM278 GDSC2 -0.2494 3.7231 -1.2353 23.8197
SK-MEL-24 GDSC2 -0.1367 4.61 -1.5249 24.8703
M14 GDSC2 -0.0667 4.9725 -1.6256 25.0957
SK-MEL-5 GDSC2 0.0962 3.0505 -0.586 18.7678
SH-4 GDSC2 0.8073 7.5815 -2.0837 24.0594
HMV-II GDSC2 1.0363 6.6493 -1.4178 20.0347
WM35 GDSC2 1.0548 3.7355 0.0412 11.4277
COLO 829 GDSC2 1.3089 6.5093 -1.1109 17.4955
WM115 GDSC2 1.3126 4.187 0.0505 10.5294
CP66-MEL GDSC2 2.0433 4.7423 0.3701 6.4554
GAK GDSC2 2.2377 6.0447 -0.127 9.0454
CHL-1 GDSC2 2.4716 5.575 0.2718 6.0565
SK-MEL-2 GDSC2 2.4894 4.0118 1.0166 1.6679
IGR-1 GDSC2 2.5702 4.8292 0.692 3.3492
UACC-257 GDSC2 2.6474 4.1837 1.0277 1.3883
G-361 GDSC2 2.7946 5.816 0.3726 4.7852
Mel JuSo GDSC2 3.7858 5.512 1.0169 0.4648
COLO 792 GDSC2 3.9693 5.7468 1.0032 0.4153
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 -4.1676 0.4584 -4.4252 56.3796
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 GDSC2 -5.3062 -0.9074 -5.4303 65.8675
EW-8 GDSC2 -3.945 -2.7126 -3.945 55.4918
KYM-1 GDSC2 -3.8566 -2.4536 -3.8569 54.6026
SW982 GDSC2 -2.4815 3.1032 -3.3436 43.1088
SK-LMS-1 GDSC2 -2.3901 0.012 -2.4463 40.13
SK-UT-1 GDSC2 -2.2021 1.5796 -2.5465 39.3471
GCT GDSC2 -1.9687 1.5039 -2.2714 36.9805
VA-ES-BJ GDSC2 -1.5885 1.7676 -1.9299 33.4758
Rh41 GDSC2 -1.1971 0.8122 -1.2804 28.3422
SW872 GDSC2 -1.1878 2.0363 -1.5753 29.7878
MES-SA GDSC2 -1.1791 2.3345 -1.665 30.1836
G-402 GDSC2 -0.6933 4.0242 -1.8226 28.6737
RD GDSC2 -0.492 3.0158 -1.186 24.5864
Rh30 GDSC2 2.0161 5.6385 -0.0947 9.415
SW684 GDSC2 2.1484 5.1908 0.2273 7.0831
A-204 GDSC2 2.1968 10.894 -2.57 21.927
HT-1080 GDSC2 2.225 4.6571 0.5441 4.9449
RKN GDSC2 2.3678 3.9715 0.9638 2.1554
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RF-48 GDSC2 -4.8455 -1.2693 -4.9069 63.0783
NUGC-3 GDSC2 -4.0379 -1.2356 -4.0686 56.1626
SNU-5 GDSC2 -3.5974 -2.3302 -3.5975 52.0046
AGS GDSC2 -3.0309 1.1943 -3.3514 46.836
MKN45 GDSC2 -2.7025 0.5753 -2.8622 43.5186
SNU-1 GDSC2 -2.3227 1.6091 -2.6862 40.532
23132/87 GDSC2 -2.2973 0.6055 -2.4303 39.5107
IM95 GDSC2 -2.0452 1.8567 -2.4542 38.1029
RERF-GC-1B GDSC2 -1.4347 1.1763 -1.6086 31.1724
NCI-N87 GDSC2 -1.1833 1.5238 -1.4196 28.9866
NUGC-4 GDSC2 -1.1441 1.6876 -1.422 28.8087
GCIY GDSC2 -0.5757 3.3867 -1.4272 26.2174
SK-GT-2 GDSC2 -0.4855 1.5529 -0.6659 21.7246
ECC10 GDSC2 -0.4273 1.6095 -0.6178 21.1966
MKN1 GDSC2 -0.1701 4.553 -1.5316 25.0395
MKN28 GDSC2 0.0378 3.3631 -0.7825 20.1349
Hs 746.T GDSC2 0.4725 2.4212 0.0721 13.3969
OCUM-1 GDSC2 1.753 6.1542 -0.5612 12.9807
KATO III GDSC2 1.8846 3.9581 0.6379 5.1793
HGC-27 GDSC2 4.5119 12.8839 -1.8508 13.295
SNG-M GDSC2 1.9813 5.3865 0.0035 8.8987
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IHH-4 GDSC2 -4.9916 -2.1398 -5.0079 65.1548
CAL-62 GDSC2 -3.6471 -0.7113 -3.6993 52.3865
8505C GDSC2 -2.878 0.6851 -3.0727 45.2542
FTC-133 GDSC2 -1.6267 2.2257 -2.1139 34.4732
K5 GDSC2 -1.361 2.2254 -1.8252 31.8367
B-CPAP GDSC2 -1.2735 1.8267 -1.6038 30.3471
8305C GDSC2 -1.1993 2.3845 -1.7042 30.4696
ASH-3 GDSC2 -1.1111 1.079 -1.2362 27.6959
BHT-101 GDSC2 -1.07 3.0011 -1.7929 30.2651
HTC-C3 GDSC2 0.7537 2.8045 0.1943 11.5625
TT2609-C02 GDSC2 1.2321 6.1334 -0.9897 17.0581
WRO GDSC2 2.3716 5.826 0.0789 7.4603
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SAS GDSC2 -3.8894 -2.4086 -3.8898 54.9287
FaDu GDSC2 -3.4354 -1.1079 -3.4538 50.3729
HSC-2 GDSC2 -3.4257 -2.0348 -3.4262 50.2826
CAL-33 GDSC2 -2.9513 -0.2099 -3.0154 45.6871
CAL-27 GDSC2 -2.8655 0.4143 -3.0097 45.034
HO-1-N-1 GDSC2 -2.6644 -0.8608 -2.6736 42.6814
PCI-04B GDSC2 -2.6599 0.2164 -2.7584 42.9357
HSC-3 GDSC2 -2.4427 -0.1953 -2.4818 40.5853
JHU-022 GDSC2 -2.4256 1.7927 -2.8503 41.6471
BICR 22 GDSC2 -2.3789 -1.433 -2.379 39.7786
HSC-4 GDSC2 -1.8125 0.8064 -1.9429 34.7175
DOK GDSC2 -1.7947 2.4017 -2.3548 36.3305
Detroit 562 GDSC2 -1.0543 1.3229 -1.2282 27.3803
SCC-4 GDSC2 -0.9908 1.1822 -1.1272 26.5502
SCC-15 GDSC2 -0.369 2.9115 -1.014 23.1215
SKN-3 GDSC2 -0.3146 1.1975 -0.3966 19.4862
UPCI-SCC-090 GDSC2 -0.2734 2.3531 -0.6947 20.9348
Ca9-22 GDSC2 -0.1378 3.4581 -1.0043 22.0986
SAT [Human HNSCC] GDSC2 0.2184 4.3055 -1.0328 20.8451
OSC-20 GDSC2 0.4439 4.6706 -0.9881 19.7474
BB49-HNC GDSC2 0.4594 3.6777 -0.5017 16.8597
NCI-H3118 GDSC2 0.577 7.2828 -2.1422 25.1165
BICR 10 GDSC2 0.9605 6.1389 -1.2313 19.2884
SCC-9 GDSC2 1.4997 3.6058 0.5026 7.1045
BICR 78 GDSC2 1.8123 4.2387 0.4425 6.598
LB771-HNC GDSC2 3.3551 6.2772 0.4981 3.127
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
639V GDSC2 -4.6462 -2.9608 -4.6467 62.474
647V GDSC2 -4.1339 -1.7543 -4.1448 57.2307
BFTC-905 GDSC2 -3.6515 -2.243 -3.6519 52.5463
KU-19-19 GDSC2 -3.4681 -1.0309 -3.4911 50.6919
CAL-29 GDSC2 -3.1242 -1.4008 -3.1281 47.2671
RT-112 GDSC2 -0.8908 1.0371 -0.9895 25.3522
J82 GDSC2 -0.685 2.7641 -1.2909 25.9943
5637 GDSC2 -0.0081 1.6467 -0.1709 16.8473
SW1710 GDSC2 0.3052 1.7396 0.1432 13.7054
SW780 GDSC2 0.6454 3.7996 -0.3777 15.4314
TCCSUP GDSC2 1.1279 8.1331 -2.0774 22.9705
HT-1197 GDSC2 1.5101 3.9264 0.3512 8.0304
RT-4 GDSC2 1.5178 4.236 0.2031 8.9425
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC2 -4.9593 -2.8393 -4.9615 65.4076
TC-YIK GDSC2 -3.9639 -2.3616 -3.9647 55.6701
NEC8 GDSC2 -3.7457 -2.4706 -3.7458 53.4926
BPH-1 GDSC2 -3.7449 -0.8232 -3.7924 53.3237
DSH1 GDSC2 -3.4227 -0.8135 -3.4572 50.2452
ME-180 GDSC2 -3.2988 -1.6196 -3.3013 49.0118
HT-3 GDSC2 -3.2516 -0.9377 -3.2727 48.561
Ca Ski GDSC2 -3.1954 -0.965 -3.2135 48.0014
PWR-1E GDSC2 -3.1199 0.3496 -3.2728 47.4429
CAL-39 GDSC2 -2.9001 -0.804 -2.9172 45.0636
C-33 A GDSC2 -1.8625 2.0953 -2.3282 36.6043
LB831-BLC GDSC2 -1.8207 1.487 -2.1055 35.4805
SW756 GDSC2 -1.2328 3.7913 -2.2834 33.162
HEY GDSC2 -1.1636 3.0478 -1.9108 31.2538
PEO1 GDSC2 -1.0534 2.8586 -1.7203 29.8447
SKG-IIIa GDSC2 -0.7986 2.1236 -1.1811 25.9314
DoTc2 4510 GDSC2 -0.774 1.4957 -0.9656 24.672
MS751 GDSC2 -0.3543 1.4584 -0.4982 20.2139
SiSo GDSC2 0.0264 3.7606 -0.972 21.2542
SKN GDSC2 0.0512 2.5195 -0.4122 17.9487
HEC-1 GDSC2 1.3126 3.3032 0.4895 7.7702
C-4-I GDSC2 1.3596 4.1217 0.1242 9.9198
OVMIU GDSC2 1.4573 4.9717 -0.2159 11.7445
SiHa GDSC2 1.8149 3.6284 0.748 4.6672
OVCA420 GDSC2 3.5954 5.5905 0.9073 0.9447
HeLa GDSC2 4.0087 12.4659 -1.992 14.9802
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT03030417) Indenoisoquinoline LMP744 in Adults With Relapsed Solid Tumors and Lymphomas. U.S. National Institutes of Health.
2 Targeting Topoisomerase I in the Era of Precision Medicine. Clin Cancer Res. 2019 Nov 15;25(22):6581-6589.