Details of the Drug

General Information of Drug (ID: DMUJ0W7)

Drug Name
CP-724714
Synonyms
CP 724714; CP-724,714; CP724,714, CP-724,714; 2-Methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide; 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
Indication
Disease Entry ICD 11 Status REF
Lymphoma 2A80-2A86 Phase 2 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 469.5
Logarithm of the Partition Coefficient (xlogp) 4.3
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C27H27N5O3
IUPAC Name
2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide
Canonical SMILES
CC1=NC=C(C=C1)OC2=C(C=C(C=C2)NC3=NC=NC4=C3C=C(C=C4)/C=C/CNC(=O)COC)C
InChI
InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+
InChIKey
LLVZBTWPGQVVLW-SNAWJCMRSA-N
Cross-matching ID
PubChem CID
9874913
ChEBI ID
CHEBI:91331
CAS Number
845680-17-3
UNII
I05QZ0S4V3
DrugBank ID
DB12302
TTD ID
D0CN9Q
VARIDT ID
DR01390
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Erbb2 tyrosine kinase receptor (HER2) TT6EO5L ERBB2_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Regulation of Drug Effects [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Lymphoma
ICD Disease Classification 2A80-2A86
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Erbb2 tyrosine kinase receptor (HER2) DTT ERBB2 5.67E-03 -1.26 -2.05
Breast cancer resistance protein (ABCG2) DTP BCRP 4.60E-05 -2.12E+00 -3.70E+00
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 3.802 5.5337 2.6129 4.4303
NOS-1 [Human HNSCC] GDSC1 3.5618 7.474 1.466 13.958
EW-1 GDSC1 4.0023 6.2417 2.4099 5.4189
TC-71 GDSC1 4.0676 5.7319 2.6959 3.1242
SK-ES-1 GDSC1 4.1703 6.3523 2.4701 4.5292
A-673 GDSC1 4.4379 5.9425 2.8143 1.6038
ES7 GDSC1 4.4613 8.6921 1.5437 10.5422
CADO-ES1 GDSC1 4.5305 6.397 2.6669 2.3773
EW-7 GDSC1 4.7371 6.5392 2.7148 1.7459
ES6 GDSC1 5.0003 7.7605 2.3263 3.7474
EW-16 GDSC1 5.0144 8.7804 1.8699 6.8249
ES8 GDSC1 5.047 7.8873 2.2963 3.8574
EW-24 GDSC1 5.1343 6.4995 2.908 0.4318
MHH-ES-1 GDSC1 5.1591 6.9815 2.7354 1.1168
H-EMC-SS GDSC1 5.2381 7.4193 2.5962 1.7358
CHSA0108 GDSC1 5.2728 7.8242 2.4449 2.5455
ES5 GDSC1 5.2939 7.9967 2.3824 2.8875
EW-13 GDSC1 5.3164 7.1728 2.73 0.9896
SK-PN-DW GDSC1 5.3278 7.8195 2.4746 2.293
CHSA8926 GDSC1 5.4229 7.5084 2.6459 1.2732
SJSA-1 GDSC1 5.4379 7.7029 2.5754 1.6051
CAL-78 GDSC1 5.5324 7.0728 2.8547 0.3845
MG-63 GDSC1 5.6131 7.0537 2.8913 0.258
CAL-72 GDSC1 5.7047 7.4033 2.802 0.4524
EW-18 GDSC1 5.7897 8.0991 2.577 1.2365
HOS GDSC1 5.7969 7.2513 2.8891 0.2046
HuO9 GDSC1 5.8057 7.9702 2.6332 0.9837
ES4 GDSC1 5.8318 15.4786 -0.7863 19.8907
CHSA0011 GDSC1 5.9669 8.7529 2.3989 1.8993
G-292 clone A141B1 GDSC1 6.0273 7.9632 2.7245 0.5187
SaOS-2 GDSC1 6.18 7.6185 2.898 0.1088
HuO-3N1 GDSC1 6.2596 8.2489 2.7105 0.449
U2OS GDSC1 6.2758 16.6341 -1.0352 19.836
NY GDSC1 6.3978 8.4173 2.7025 0.4122
ES1 GDSC1 6.4612 8.1002 2.8333 0.144
EW-3 GDSC1 6.9254 8.8404 2.7448 0.1799
EW-11 GDSC1 6.9408 9.2126 2.6235 0.397
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 4.1838 6.032 2.629 3.3391
MY-M12 GDSC1 2.1544 9.5861 -0.8094 32.1638
BL-41 GDSC1 2.7302 7.5201 0.732 22.1697
THP-1 GDSC1 2.8754 4.6058 2.2963 10.2787
SU-DHL-5 GDSC1 3.3006 4.2045 2.8848 3.9237
SIG-M5 GDSC1 3.4005 4.1882 2.9764 2.8379
SUP-M2 GDSC1 3.4684 4.6157 2.8173 3.8599
SU-DHL-16 GDSC1 3.4982 4.6806 2.8083 3.8332
WIL2 NS GDSC1 3.5079 5.6363 2.34 7.4786
LP-1 GDSC1 3.6018 6.0551 2.2055 8.2149
MV4-11 GDSC1 3.6564 5.0041 2.7671 3.6648
K-562 GDSC1 3.6677 5.0594 2.7482 3.7774
SU-DHL-6 GDSC1 3.6969 5.1069 2.746 3.7094
Karpas-620 GDSC1 3.6977 6.7015 1.9589 9.805
EoL-1 GDSC1 3.6984 6.9637 1.8291 10.7918
BC-1 GDSC1 3.8066 7.064 1.8629 10.1808
QIMR-WIL GDSC1 3.8081 5.6524 2.5594 4.8235
GR-ST GDSC1 3.8602 6.913 1.9783 9.134
NB4 GDSC1 3.8915 6.6796 2.1167 7.9796
ALL-PO GDSC1 3.926 6.1915 2.3807 5.855
697 GDSC1 3.9263 5.3798 2.7709 2.9132
OCI-M1 GDSC1 4.0168 6.7469 2.1749 7.1642
AMO1 GDSC1 4.0176 6.0617 2.507 4.6456
KOPN-8 GDSC1 4.0353 6.2194 2.4434 5.077
MOLT-13 GDSC1 4.041 5.9894 2.5572 4.2091
Ku812 GDSC1 4.052 6.3406 2.3964 5.3861
HEL GDSC1 4.0703 6.4031 2.3789 5.4687
A3/Kawakami GDSC1 4.0847 7.76 1.7279 10.3186
CESS GDSC1 4.1084 5.9741 2.6084 3.6644
YT GDSC1 4.1206 6.1463 2.5352 4.1722
WSU-DLCL2 GDSC1 4.1234 7.3627 1.9507 8.5473
EB2 GDSC1 4.134 6.1068 2.5625 3.9389
Ramos.2G6.4C10 GDSC1 4.16 7.3389 1.9884 8.1591
NALM-6 GDSC1 4.1621 7.5553 1.8845 8.9285
OCI-AML-2 GDSC1 4.2022 7.003 2.1806 6.6027
Sc-1 GDSC1 4.222 7.4962 1.9557 8.2269
Farage GDSC1 4.2601 5.8422 2.7611 2.2569
Namalwa GDSC1 4.2648 6.2383 2.5835 3.4815
ARH-77 GDSC1 4.2663 5.8684 2.7529 2.2998
OCI-AML-3 GDSC1 4.2781 6.8899 2.2859 5.6194
TUR GDSC1 4.2784 7.9013 1.7988 9.2257
P30/OHK GDSC1 4.2809 9.1751 1.1768 13.6135
U-698-M GDSC1 4.2828 6.0345 2.6877 2.7119
ML-2 GDSC1 4.2872 6.2371 2.5978 3.3304
L-363 GDSC1 4.2891 5.8983 2.7526 2.2582
JSC-1 GDSC1 4.3242 7.2469 2.1464 6.5325
P31/FUJ GDSC1 4.3312 5.7835 2.8264 1.702
L-428 GDSC1 4.3411 6.4913 2.5136 3.8095
NKM-1 GDSC1 4.3453 6.5285 2.499 3.9042
CCRF-CEM GDSC1 4.3653 6.4728 2.537 3.5897
DEL GDSC1 4.3938 8.9485 1.3705 11.9494
KG-1 GDSC1 4.3995 7.9943 1.8385 8.5953
CA46 GDSC1 4.4143 6.6283 2.4952 3.7775
MOLT-16 GDSC1 4.4296 8.1866 1.7664 9.0366
P12-Ichikawa GDSC1 4.4312 6.1931 2.7017 2.3297
ST486 GDSC1 4.4386 6.1576 2.7215 2.1873
MOLP-8 GDSC1 4.4492 6.3167 2.657 2.5922
BALL-1 GDSC1 4.4681 6.8476 2.4271 4.1412
SCC-3 GDSC1 4.4872 6.3289 2.673 2.416
SUP-T1 GDSC1 4.4878 7.5013 2.1338 6.2075
KCL-22 GDSC1 4.4926 6.5588 2.5734 3.0711
RPMI-8866 GDSC1 4.5203 7.5238 2.1443 6.0513
CTV-1 GDSC1 4.5306 6.2148 2.7462 1.8744
JVM-3 GDSC1 4.5434 6.3507 2.6942 2.1795
SUP-HD1 GDSC1 4.5492 6.6918 2.5464 3.1427
NU-DUL-1 GDSC1 4.5552 6.3834 2.6863 2.2094
Loucy GDSC1 4.5824 6.3163 2.7298 1.8919
H9 GDSC1 4.5845 6.8863 2.4792 3.5299
MC116 GDSC1 4.5928 5.5899 3.0269 0.3602
SU-DHL-1 GDSC1 4.5985 5.6959 2.9896 0.4985
KMS-12-BM GDSC1 4.6228 6.6549 2.6044 2.6184
BE-13 GDSC1 4.6384 7.7541 2.1119 5.9998
OPM-2 GDSC1 4.6413 6.4657 2.6967 2.0016
U266B1 GDSC1 4.661 6.8637 2.5334 3.0149
JURL-MK1 GDSC1 4.702 7.5981 2.2242 5.0552
MOLM-13 GDSC1 4.7176 7.5761 2.244 4.8819
SUP-B15 GDSC1 4.7579 6.6312 2.6866 1.882
BV-173 GDSC1 4.7766 6.7913 2.628 2.2077
RPMI-8402 GDSC1 4.7854 6.7061 2.6689 1.9458
Karpas-299 GDSC1 4.8397 7.4908 2.3551 3.8632
HL-60 GDSC1 4.8707 6.0472 2.9694 0.3843
HT GDSC1 4.8725 6.5263 2.7858 1.1779
RL GDSC1 4.8796 8.5991 1.8695 7.143
Daudi GDSC1 4.902 6.9528 2.6241 2.0377
A4/Fukuda GDSC1 4.9114 6.7917 2.6962 1.6098
ALL-SIL GDSC1 4.9269 6.4584 2.8373 0.8701
KY821 GDSC1 4.9648 6.5 2.8377 0.8326
SU-DHL-4 GDSC1 4.9837 6.3816 2.891 0.5931
PL-21 GDSC1 4.9954 7.53 2.4251 3.1156
Karpas-45 GDSC1 4.9962 9.0626 1.7265 7.8592
RPMI-8226 GDSC1 4.998 6.7087 2.7706 1.1148
EM-2 GDSC1 4.9998 6.6873 2.7799 1.0675
LC4-1 GDSC1 5.0149 7.4147 2.4856 2.7018
NOMO-1 GDSC1 5.0242 6.6433 2.808 0.911
ME1 GDSC1 5.0683 6.3729 2.9282 0.404
Karpas-231 GDSC1 5.0872 13.8641 -0.5342 20.7653
SU-DHL-10 GDSC1 5.1021 5.9568 3.0843 0.0543
OCI-AML-5 GDSC1 5.1508 6.289 2.989 0.1995
VAL GDSC1 5.1656 7.7726 2.4112 2.9164
KMS-11 GDSC1 5.1732 10.4532 1.1837 11.0611
MOLT-4 GDSC1 5.1991 7.7328 2.4458 2.652
SU-DHL-8 GDSC1 5.2055 14.7899 -0.9023 22.0295
DG-75 GDSC1 5.2065 7.2075 2.6671 1.4019
ATN-1 GDSC1 5.2131 6.832 2.8164 0.7126
GDM-1 GDSC1 5.2301 7.572 2.5293 2.1172
MN-60 GDSC1 5.2363 7.3016 2.6431 1.4907
BC-3 GDSC1 5.2424 10.4671 1.223 10.6316
Reh GDSC1 5.2622 6.9007 2.8108 0.6969
RPMI-6666 GDSC1 5.2724 6.9249 2.806 0.7082
Karpas-422 GDSC1 5.2814 6.9321 2.807 0.6974
RC-K8 GDSC1 5.2855 6.5122 2.9604 0.2169
L-1236 GDSC1 5.3026 7.6379 2.5376 1.9727
KMOE-2 GDSC1 5.3246 7.4951 2.6063 1.5775
Granta-519 GDSC1 5.3607 7.1929 2.7413 0.9017
L-540 GDSC1 5.3885 7.0656 2.8009 0.6433
LAMA-84 GDSC1 5.4274 7.2371 2.7526 0.8007
Mono-Mac-6 GDSC1 5.434 9.7128 1.6972 7.0604
Raji GDSC1 5.4344 6.807 2.912 0.2755
WSU-NHL GDSC1 5.4382 6.824 2.9075 0.2852
Hs 445 GDSC1 5.4409 6.9084 2.8786 0.3603
EJM GDSC1 5.4579 7.1559 2.7954 0.6165
TK [Human B-cell lymphoma] GDSC1 5.4593 6.9277 2.8787 0.3515
JVM-2 GDSC1 5.4941 8.7431 2.1666 3.8899
KE-37 GDSC1 5.5077 6.5753 3.0165 0.0721
HH [Human lymphoma] GDSC1 5.5149 7.7882 2.5767 1.5123
P32/ISH GDSC1 5.521 6.8049 2.9439 0.1776
DB GDSC1 5.5359 7.6862 2.6264 1.2523
PF-382 GDSC1 5.6083 7.3957 2.7671 0.6189
JJN-3 GDSC1 5.7266 7.2117 2.8776 0.2496
HDLM-2 GDSC1 5.7779 7.8708 2.6591 0.9015
Kasumi-1 GDSC1 5.7994 7.6897 2.735 0.6107
MLMA GDSC1 5.8539 7.7349 2.7399 0.5634
SK-MM-2 GDSC1 5.8993 7.5993 2.8056 0.3547
HC-1 GDSC1 5.9191 7.4887 2.8512 0.2436
CTB-1 GDSC1 5.9721 8.3158 2.5718 1.1005
VL51 GDSC1 5.9736 7.7122 2.7933 0.3555
OCI-Ly19 GDSC1 5.9991 7.6593 2.8211 0.2815
Jiyoye GDSC1 6.003 7.9275 2.728 0.5205
MHH-PREB-1 GDSC1 6.016 7.6942 2.8151 0.289
KM-H2 GDSC1 6.0163 7.5549 2.863 0.1939
RS4;11 GDSC1 6.0227 7.7068 2.8131 0.291
HAL-01 GDSC1 6.0633 7.8381 2.7822 0.3476
SR GDSC1 6.1566 15.0314 -0.3447 17.1007
DND-41 GDSC1 6.199 7.7682 2.8545 0.1651
MEG-01 GDSC1 6.3611 8.332 2.7188 0.3865
ROS-50 GDSC1 6.6712 8.8397 2.655 0.4216
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYAE-1 GDSC1 -2.2634 5.6037 -3.5096 60.1338
ESO-26 GDSC1 1.8598 10.3144 -1.4371 35.4518
TE-12 GDSC1 3.3724 5.582 2.2567 8.608
OACP4 C GDSC1 3.7558 8.7832 0.968 16.7172
KYSE-50 GDSC1 4.2574 7.7587 1.8532 8.8857
OACM5.1 C GDSC1 4.4769 7.0807 2.3244 4.854
ESO-51 GDSC1 4.8374 7.0468 2.5501 2.5927
FLO-1 GDSC1 5.2007 8.3499 2.1773 4.3495
HCE-4 GDSC1 5.2354 7.218 2.6762 1.3242
KYSE-220 GDSC1 5.323 10.0126 1.4894 8.6881
SK-GT-4 GDSC1 5.5546 8.3293 2.3747 2.5454
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 4.5256 7.1602 2.3179 4.7886
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-7 GDSC1 2.5225 4.0156 2.2089 12.6046
SJNB-17 GDSC1 3.7093 6.3282 2.1531 8.2699
SK-N-DZ GDSC1 3.7574 5.1147 2.7846 3.2452
SJNB-5 GDSC1 3.865 5.5837 2.6326 4.105
LA-N-6 GDSC1 3.9781 6.8348 2.104 7.817
KP-N-YN GDSC1 3.9862 6.6159 2.2169 6.9328
NB1 GDSC1 4.0079 8.1292 1.4887 12.2983
SK-N-BE(2)-M17 GDSC1 4.1146 6.9593 2.1409 7.1428
Kelly GDSC1 4.3221 6.0912 2.6851 2.6501
SJNB-12 GDSC1 4.6362 7.8371 2.0715 6.294
SJNB-10 GDSC1 4.6751 6.3862 2.7479 1.6427
SK-N-FI GDSC1 4.7024 6.4679 2.7273 1.7235
KP-N-YS GDSC1 4.7578 8.6859 1.7494 8.288
IMR-5 GDSC1 4.7784 6.8195 2.6168 2.2735
SJNB-14 GDSC1 4.8535 6.5158 2.7812 1.2239
CHP-212 GDSC1 4.8685 6.5088 2.791 1.156
MHH-NB-11 GDSC1 4.9164 7.4919 2.3982 3.4306
CHP-126 GDSC1 4.9738 6.826 2.7121 1.4428
SJNB-13 GDSC1 4.9957 6.6783 2.7816 1.0637
NB(TU)1 GDSC1 4.9969 6.8079 2.7304 1.3191
SJNB-6 GDSC1 5.0042 7.2083 2.5682 2.2164
SiMa GDSC1 5.0123 7.6379 2.3871 3.3294
SK-N-MC-IXC GDSC1 5.1053 6.0704 3.0476 0.1014
GI-ME-N GDSC1 5.1864 10.4951 1.1726 11.0989
SK-N-AS GDSC1 5.1872 6.9051 2.7775 0.8971
TGW GDSC1 5.2701 6.7014 2.8876 0.4203
NB69 GDSC1 5.4121 7.5241 2.6349 1.3375
SK-N-SH GDSC1 5.4851 7.264 2.7663 0.7046
GOTO GDSC1 5.5219 7.44 2.7152 0.8768
CHP-134 GDSC1 5.6881 7.0565 2.9171 0.182
NH-12 GDSC1 6.0816 7.5262 2.8952 0.1292
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 4.5506 6.6749 2.5548 3.083
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC2218 GDSC1 -2.8476 5.2054 -3.9962 63.395
BT-474 GDSC1 -1.6985 5.0587 -2.7036 57.4898
MDA-MB-175-VII GDSC1 0.2172 5.7269 -0.9171 42.9069
OCUB-M GDSC1 0.7762 8.4287 -1.556 40.889
HCC1419 GDSC1 2.4395 12.5758 -2.0382 34.7368
AU565 GDSC1 2.5503 10.7542 -1.0342 31.3139
UACC-893 GDSC1 3.0105 7.1543 1.1618 18.1959
MDA-MB-453 GDSC1 3.0884 10.3016 -0.3421 26.4324
CAL-85-1 GDSC1 3.5403 5.5811 2.3932 6.9515
COLO 824 GDSC1 3.8082 5.4221 2.6713 3.9671
BT-549 GDSC1 3.861 7.1469 1.8633 10.0034
DU4475 GDSC1 3.8804 7.0042 1.9485 9.2975
MDA-MB-468 GDSC1 3.9118 6.1866 2.373 5.9543
CAMA-1 GDSC1 4.023 6.1988 2.4448 5.099
HCC1500 GDSC1 4.4038 7.1429 2.2485 5.5793
HCC1187 GDSC1 4.4487 7.6378 2.0431 6.9688
MFM-223 GDSC1 4.5226 6.0658 2.8056 1.5269
HCC1599 GDSC1 4.5762 6.5762 2.6132 2.6453
HCC1954 GDSC1 4.647 15.4625 -1.6578 26.4314
BT-483 GDSC1 4.6481 9.1234 1.4653 10.5678
BT-20 GDSC1 4.6555 6.4653 2.7043 1.9323
UACC-812 GDSC1 4.679 9.6755 1.2195 12.153
EFM-192A GDSC1 4.703 6.624 2.6612 2.1214
MCF-7 GDSC1 4.7493 6.6286 2.6833 1.9148
CAL-51 GDSC1 4.7538 6.5363 2.7245 1.6658
YMB-1-E GDSC1 4.7741 7.5658 2.2827 4.4906
MDA-MB-231 GDSC1 4.7942 7.6276 2.2665 4.5605
MDA-MB-436 GDSC1 4.8246 6.8638 2.6221 2.1678
CAL-148 GDSC1 4.8464 6.4896 2.7885 1.1946
MDA-MB-330 GDSC1 4.8676 8.1126 2.0884 5.6385
HCC2157 GDSC1 4.87 6.4748 2.8053 1.082
HCC1806 GDSC1 4.9024 6.7081 2.7262 1.4566
HDQ-P1 GDSC1 4.9204 6.9363 2.6404 1.9153
EFM-19 GDSC1 4.9706 7.3356 2.4962 2.7086
HCC1569 GDSC1 4.9831 9.1569 1.6737 8.2549
Evsa-T GDSC1 5.0729 6.5232 2.8745 0.5908
HCC1428 GDSC1 5.1192 7.5735 2.4723 2.6164
JIMT-1 GDSC1 5.2205 6.8579 2.8097 0.7336
CAL-120 GDSC1 5.344 6.6871 2.9207 0.2901
MRK-nu-1 GDSC1 5.4672 6.7799 2.9333 0.215
MDA-MB-415 GDSC1 5.4746 7.4102 2.7066 0.9517
ZR-75-30 GDSC1 5.5993 15.7988 -1.1092 21.8182
HCC1937 GDSC1 5.6475 8.0815 2.5204 1.6466
Hs 578T GDSC1 5.6637 7.6675 2.6884 0.8733
HCC70 GDSC1 5.7838 7.8135 2.6831 0.8051
MDA-MB-361 GDSC1 5.8833 12.7766 0.5489 13.1408
HCC1395 GDSC1 5.8952 7.7589 2.7472 0.5185
HCC38 GDSC1 5.9818 8.8778 2.3556 2.1014
MDA-MB-157 GDSC1 6.2552 7.928 2.82 0.2089
T-47D GDSC1 8.9477 21.4736 -1.575 16.4104
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-247MG GDSC1 2.8156 5.5052 1.8035 14.3201
Daoy GDSC1 3.2273 6.3189 1.766 12.95
AM-38 GDSC1 3.508 5.4362 2.4398 6.6947
SK-MG-1 GDSC1 3.842 6.2366 2.298 6.736
KS-1 [Human Krukenberg tumour] GDSC1 3.971 7.1426 1.9477 9.0238
CAS-1 GDSC1 4.1227 11.6505 -0.1708 21.9683
GaMG GDSC1 4.2358 5.4646 2.9133 1.3176
LN-18 GDSC1 4.2539 5.1533 3.0502 0.5413
Hs 683 GDSC1 4.2638 5.6465 2.8497 1.6689
D-542MG GDSC1 4.4064 6.4245 2.5837 3.1756
DBTRG-05MG GDSC1 4.494 6.2197 2.7246 2.0709
8-MG-BA GDSC1 4.5038 6.762 2.488 3.6362
YKG-1 GDSC1 4.5508 6.4833 2.6401 2.5154
U-251MG GDSC1 4.5765 7.4045 2.2361 5.2559
MOG-G-CCM GDSC1 4.5803 7.3249 2.2755 4.9659
D283 Med GDSC1 4.6073 6.0273 2.8631 1.089
KNS-42 GDSC1 4.7165 6.261 2.8199 1.1849
U-118MG GDSC1 4.7288 7.1835 2.4292 3.5817
Becker GDSC1 4.731 6.9968 2.5137 3.0147
SF295 GDSC1 4.7613 6.6761 2.6693 1.9805
LNZTA3WT4 GDSC1 4.781 7.6619 2.243 4.7515
GB-1 GDSC1 4.8548 6.3654 2.8418 0.9205
D-423MG GDSC1 4.9372 10.4564 1.0217 12.7275
LN-229 GDSC1 4.9622 6.8736 2.6871 1.5934
NMC-G1 GDSC1 4.9628 6.4064 2.8728 0.6829
Onda 10 GDSC1 5.0256 6.9057 2.7043 1.4215
D-502MG GDSC1 5.1194 9.3595 1.6659 7.9812
DK-MG GDSC1 5.1281 6.2896 2.9805 0.2274
A-172 GDSC1 5.1825 7.5884 2.4984 2.3637
D-336MG GDSC1 5.2257 8.1113 2.2965 3.5335
D-263MG GDSC1 5.2259 6.6133 2.9023 0.3983
GI-1 GDSC1 5.3068 7.5508 2.5753 1.762
LN-405 GDSC1 5.3975 6.7071 2.9334 0.2386
SF539 GDSC1 5.4182 6.7361 2.9308 0.2371
PFSK-1 GDSC1 5.4345 7.6387 2.5995 1.4872
SW1783 GDSC1 5.4435 7.4168 2.6907 1.048
D-566MG GDSC1 5.4621 7.5084 2.6633 1.1538
YH-13 GDSC1 5.4653 6.7168 2.9544 0.1734
M059J GDSC1 5.4671 7.3232 2.7366 0.8338
U-87MG ATCC GDSC1 5.4987 6.6677 2.9826 0.1175
D-392MG GDSC1 5.505 7.4251 2.7138 0.8962
H4 GDSC1 5.6318 7.2672 2.8229 0.4274
T98G GDSC1 5.6643 8.8575 2.2074 3.3618
ONS-76 GDSC1 5.6678 7.0706 2.9051 0.2108
KINGS-1 GDSC1 5.7752 7.8179 2.6779 0.8308
KNS-81-FD GDSC1 5.7813 7.2871 2.8712 0.2453
MOG-G-UVW GDSC1 5.8762 8.0186 2.6442 0.886
SF268 GDSC1 5.9283 7.8046 2.7435 0.5125
42-MG-BA GDSC1 5.9451 7.5577 2.8367 0.2656
SNB-75 GDSC1 5.9891 8.1572 2.6386 0.8269
SW1088 GDSC1 6.0258 7.4894 2.8884 0.1499
Onda 11 GDSC1 6.11 8.576 2.531 1.156
KALS-1 GDSC1 6.1677 8.2103 2.6895 0.5512
SF126 GDSC1 6.2566 7.7373 2.8845 0.1131
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 4.0101 6.0169 2.5234 4.5423
ETK-1 GDSC1 4.2732 8.0101 1.742 9.6561
TGBC1TKB GDSC1 5.2038 6.6515 2.8798 0.4842
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EN GDSC1 4.3652 6.1971 2.6624 2.719
MFE-319 GDSC1 4.4841 5.853 2.8753 1.1797
MFE-280 GDSC1 4.5188 9.7042 1.0912 13.4652
RL95-2 GDSC1 4.5748 6.2126 2.7701 1.6597
ESS-1 GDSC1 4.7653 6.2698 2.8391 1.0287
MFE-296 GDSC1 4.8525 6.6465 2.7274 1.5147
AN3-CA GDSC1 5.0376 7.0682 2.6435 1.7355
KLE GDSC1 5.0727 11.6413 0.5423 15.2714
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-21 GDSC1 2.376 9.0175 -0.3278 29.2763
RCC10RGB GDSC1 3.7884 5.1108 2.8076 2.9884
KTCTL-1M GDSC1 3.8758 6.449 2.2185 7.2465
786-O GDSC1 4.0577 5.9617 2.5814 3.9871
SW13 GDSC1 4.1978 5.7196 2.7803 2.2487
LB1047-RCC GDSC1 4.2414 8.4813 1.4887 11.5753
SN12C GDSC1 4.2803 6.6378 2.4068 4.724
HA7-RCC GDSC1 4.2871 6.3561 2.5428 3.7228
RXF 393L GDSC1 4.2929 7.332 2.0843 7.0756
KTCTL-195 GDSC1 4.3528 7.6078 1.9927 7.5923
BFTC-909 GDSC1 4.3558 6.1116 2.6954 2.5142
KTCTL-140 GDSC1 4.3728 7.4007 2.1055 6.7074
VMRC-RCW GDSC1 4.4279 6.3286 2.6395 2.7509
UO-31 GDSC1 4.4342 7.0399 2.3165 5.0114
A-498 GDSC1 4.4767 6.1121 2.7619 1.8644
VMRC-RCZ GDSC1 4.4875 6.4459 2.6211 2.759
OS-RC-2 GDSC1 4.5788 6.9923 2.4277 3.8976
SW156 GDSC1 4.6499 7.3243 2.3186 4.507
NCC021 GDSC1 4.9562 9.4649 1.5102 9.4437
769-P GDSC1 4.9776 10.8015 0.8829 13.4906
TK-10 GDSC1 5.2737 10.6737 1.1455 11.0517
KMRC-20 GDSC1 5.3028 7.5533 2.5723 1.7831
KTCTL-13 GDSC1 5.3262 7.3219 2.6761 1.2284
KMRC-1 GDSC1 5.4064 6.9083 2.8655 0.4154
ACHN GDSC1 5.5146 12.332 0.5147 14.2521
KTCTL-26A GDSC1 5.5505 7.3582 2.7578 0.6905
BB65-RCC GDSC1 5.8338 7.7152 2.7392 0.5769
A-704 GDSC1 5.9762 7.6154 2.828 0.2741
LB996-RCC GDSC1 6.0009 8.138 2.6504 0.7759
LB2241-RCC GDSC1 6.3212 8.1627 2.7631 0.3003
CAL-54 GDSC1 6.3921 8.4836 2.6769 0.4802
Caki-1 GDSC1 8.1596 17.5652 -0.2567 12.459
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW626 GDSC1 2.7634 6.5988 1.2177 18.8311
HT115 GDSC1 3.6055 5.2419 2.6121 5.0243
GP5d GDSC1 3.9097 5.7958 2.5612 4.5254
SNU-175 GDSC1 4.1695 13.5585 -1.084 25.789
RCM-1 [Human ESC] GDSC1 4.1848 6.3943 2.4597 4.5699
SNU-81 GDSC1 4.2205 8.3382 1.5436 11.2468
LS123 GDSC1 4.2489 6.9998 2.2139 6.2297
SW837 GDSC1 4.2926 9.2057 1.1704 13.62
SW1463 GDSC1 4.3366 14.1024 -1.2234 25.802
HCT 116 GDSC1 4.3641 6.4736 2.5358 3.6007
LS411N GDSC1 4.5689 5.863 2.9115 0.884
LS180 GDSC1 4.6179 7.5287 2.2042 5.3881
RKO GDSC1 4.6554 6.4603 2.7064 1.9199
COLO205 GDSC1 4.7824 7.3641 2.379 3.8153
SW48 GDSC1 4.8397 7.9354 2.153 5.25
SW948 GDSC1 4.8713 6.7231 2.7049 1.6146
COLO 320HSR GDSC1 4.8792 7.9085 2.1891 4.9147
SW620 GDSC1 4.8986 6.8525 2.6646 1.8063
CCK-81 GDSC1 4.9188 11.2863 0.6059 15.3311
KM12 GDSC1 4.9217 7.2113 2.5239 2.6167
SNU-C5 GDSC1 5.0045 7.443 2.4678 2.8294
HT-29 GDSC1 5.0265 11.4896 0.5834 15.1608
HCT 15 GDSC1 5.0341 8.5702 1.9793 6.0259
MDST8 GDSC1 5.1139 6.6835 2.8311 0.7317
SW1417 GDSC1 5.2147 7.8011 2.4247 2.7551
T84 GDSC1 5.2988 7.4562 2.61 1.5889
LS1034 GDSC1 5.3396 6.7566 2.8944 0.3638
NCI-H716 GDSC1 5.3433 7.6526 2.5511 1.8464
CW-2 GDSC1 5.3722 11.2183 0.9517 12.0225
SW1116 GDSC1 5.3924 6.8506 2.8809 0.3772
C2BBe1 GDSC1 5.441 7.9424 2.4793 2.1127
SNU-407 GDSC1 5.4594 12.5871 0.3542 15.2942
CL-11 GDSC1 5.4634 7.3288 2.7329 0.8517
HT-55 GDSC1 5.5806 7.0656 2.8752 0.3085
CaR-1 GDSC1 5.6774 7.8623 2.6198 1.149
NCI-H747 GDSC1 5.7065 12.3943 0.6138 13.2018
HCC2998 GDSC1 5.7333 7.7968 2.6685 0.8986
SNU-C1 GDSC1 5.8563 7.8476 2.6997 0.696
SNU-61 GDSC1 6.0523 13.7483 0.1988 14.6439
LoVo GDSC1 6.1869 8.0416 2.7564 0.3626
SNU-C2B GDSC1 6.189 12.6922 0.7848 11.0828
COLO 678 GDSC1 6.2967 8.1365 2.7633 0.3078
LS513 GDSC1 7.0258 15.0994 0.188 12.5257
SNU-1040 GDSC1 7.6068 20.1299 -1.8075 19.8042
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.5354 5.6044 2.3777 7.09
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-449 GDSC1 3.1133 3.9676 2.8302 5.1201
SNU-423 GDSC1 3.7505 5.5163 2.5845 4.7973
HLE GDSC1 3.8721 5.9002 2.4842 5.2166
JHH-1 GDSC1 4.0018 12.9593 -0.9186 25.674
Hep 3B2.1-7 GDSC1 4.0773 6.0672 2.5442 4.2138
HuH-1 GDSC1 4.4194 6.2543 2.6679 2.5764
JHH-4 GDSC1 4.5752 6.2199 2.7672 1.6763
Huh-7 GDSC1 4.6134 6.6337 2.6085 2.6083
JHH-6 GDSC1 4.6137 5.6721 3.0049 0.4271
JHH-7 GDSC1 4.6553 7.3947 2.2894 4.7
SNU-387 GDSC1 4.6907 6.8388 2.561 2.7782
Hep-G2/C3A GDSC1 5.0577 6.4441 2.8979 0.5146
SK-HEP-1 GDSC1 5.0586 6.492 2.8804 0.5789
SNU-475 GDSC1 5.2186 6.8548 2.8101 0.7334
SNU-398 GDSC1 5.3585 7.7685 2.5109 2.0469
JHH-2 GDSC1 5.5669 7.3078 2.783 0.5902
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 171 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Calu-3 GDSC1 2.3283 8.4551 -0.0935 28.424
NCI-H1755 GDSC1 2.9369 4.8343 2.2441 10.4153
EMC-BAC-1 GDSC1 3.1556 7.5002 1.1147 17.9435
NCI-H847 GDSC1 3.43 5.2372 2.4765 6.6742
CAL-12T GDSC1 3.7423 6.5041 2.0913 8.6417
BEN GDSC1 3.7599 5.5742 2.5629 4.9365
ABC-1 GDSC1 3.7613 7.6826 1.5206 12.8743
SHP-77 GDSC1 3.8065 8.0924 1.3521 13.9293
LCLC-97TM1 GDSC1 3.8094 11.2975 -0.2434 23.3647
HCC827 GDSC1 3.8121 5.2945 2.7356 3.4682
NCI-H3255 GDSC1 3.8491 8.9868 0.9403 16.5773
COR-L105 GDSC1 3.8926 7.3482 1.7877 10.4717
HARA [Human squamous cell lung carcinoma] GDSC1 3.8955 6.8164 2.0523 8.4598
NCI-H1048 GDSC1 3.9477 5.7605 2.6041 4.0999
SBC-5 GDSC1 3.9509 5.2005 2.8699 2.141
SK-MES-1 GDSC1 3.9526 6.4361 2.2805 6.5442
PC-14 GDSC1 3.9628 7.1068 1.9592 8.9616
PaCa-3 GDSC1 3.9746 8.0004 1.5272 12.1273
NCI-H1563 GDSC1 4.0146 6.5451 2.2715 6.4361
NCI-H1694 GDSC1 4.021 5.5914 2.732 2.971
NCI-H1993 GDSC1 4.0228 8.8229 1.1565 14.5667
COLO 668 GDSC1 4.0747 5.79 2.6732 3.2721
NCI-H2444 GDSC1 4.0773 5.6163 2.7556 2.6735
NCI-H1648 GDSC1 4.0955 7.3359 1.9437 8.6808
EPLC-272H GDSC1 4.1161 6.4106 2.4064 5.1412
NCI-H2795 GDSC1 4.1972 7.2605 2.0527 7.5732
NCI-H2196 GDSC1 4.201 6.1536 2.5832 3.6289
HCC78 GDSC1 4.208 5.8909 2.7087 2.7219
NCI-H2804 GDSC1 4.2195 6.5745 2.3971 4.9453
NCI-H1437 GDSC1 4.2259 6.2289 2.5637 3.7118
COR-L311 GDSC1 4.2394 6.3881 2.4979 4.1575
NCI-H838 GDSC1 4.2531 7.1806 2.13 6.8433
NCI-H226 GDSC1 4.2645 6.3276 2.542 3.7798
LK-2 GDSC1 4.3009 7.8994 1.8156 9.0385
NCI-H2722 GDSC1 4.3057 6.2006 2.6257 3.0945
NCI-H596 GDSC1 4.3136 7.7916 1.8768 8.5532
NCI-H2171 GDSC1 4.3244 6.2955 2.5936 3.2798
COR-L23 GDSC1 4.3316 7.3523 2.1009 6.8496
NCI-H1876 GDSC1 4.374 6.3771 2.586 3.2272
NCI-H1092 GDSC1 4.3905 6.6571 2.4673 4.0284
Lu-165 GDSC1 4.4212 6.1057 2.7347 2.1328
NCI-H524 GDSC1 4.4299 6.2004 2.6978 2.3579
SBC-3 GDSC1 4.4332 6.7771 2.4382 4.1398
NCI-H1568 GDSC1 4.4477 7.1877 2.2558 5.4193
NCI-H647 GDSC1 4.4567 7.2656 2.2249 5.6215
EKVX GDSC1 4.465 7.7097 2.0197 7.0971
LXF 289 GDSC1 4.4861 7.4532 2.1554 6.0543
DMS 273 GDSC1 4.4884 7.179 2.2858 5.1049
NCI-H187 GDSC1 4.4928 5.7008 2.9413 0.8186
NCI-H2342 GDSC1 4.4936 6.4116 2.6399 2.6223
EBC-1 GDSC1 4.4939 6.9614 2.3904 4.3439
Ms-1 GDSC1 4.4951 7.5861 2.0984 6.4473
NCI-H841 GDSC1 4.4976 6.5551 2.578 3.0298
NCI-H1581 GDSC1 4.5044 7.2097 2.2815 5.0983
NCI-H441 GDSC1 4.5321 6.495 2.6245 2.6522
NCI-H1869 GDSC1 4.5605 8.1598 1.8687 7.9451
HCC33 GDSC1 4.5654 8.3937 1.76 8.7141
NCI-H82 GDSC1 4.583 6.1078 2.8183 1.3668
HOP-62 GDSC1 4.5843 6.2713 2.7501 1.7656
NCI-H64 GDSC1 4.6086 7.4085 2.2543 5.0526
NCI-H2085 GDSC1 4.6279 7.4483 2.2478 5.0549
DMS 53 GDSC1 4.6289 7.0781 2.4184 3.8572
NCI-H526 GDSC1 4.6478 6.4538 2.7052 1.9392
NCI-H1688 GDSC1 4.6491 9.6056 1.2324 12.1522
NCI-H345 GDSC1 4.6774 5.4679 3.1022 0.1129
DMS 79 GDSC1 4.694 6.7463 2.6034 2.4992
SK-LU-1 GDSC1 4.6944 7.1685 2.416 3.74
NCI-H727 GDSC1 4.7246 8.9378 1.6069 9.3755
NCI-H1770 GDSC1 4.7572 6.2889 2.8277 1.096
NCI-H650 GDSC1 4.7615 6.5922 2.7049 1.7688
UMC-11 GDSC1 4.7874 7.0938 2.5023 2.9864
NCI-H2135 GDSC1 4.808 6.6554 2.7017 1.7204
NCI-H1975 GDSC1 4.8224 10.1018 1.1134 12.4521
NCI-H520 GDSC1 4.8293 6.813 2.6462 2.0155
NCI-H460 GDSC1 4.8299 6.4271 2.8059 1.124
NCI-H211 GDSC1 4.8416 10.456 0.9551 13.4153
NCI-H2087 GDSC1 4.8423 7.1815 2.4939 2.9423
Calu-6 GDSC1 4.8453 6.5887 2.7476 1.4127
NCI-H358 GDSC1 4.8546 12.3133 0.0567 18.5625
NCI-H69 GDSC1 4.8576 6.5692 2.7615 1.3228
NCI-H1355 GDSC1 4.8615 7.217 2.489 2.9404
NCI-H1836 GDSC1 4.8857 6.5862 2.7678 1.2555
NCI-H1793 GDSC1 4.8906 6.8329 2.6688 1.7935
NCI-H2818 GDSC1 4.8908 7.6346 2.3201 3.9987
RERF-LC-KJ GDSC1 4.9272 6.8876 2.6641 1.7689
Lu-65 GDSC1 4.9407 7.4928 2.4113 3.301
NCI-H3122 GDSC1 4.9585 8.1629 2.1205 5.2187
NCI-H2081 GDSC1 4.9606 6.8615 2.6913 1.5722
IA-LM GDSC1 4.9674 6.7793 2.7281 1.3662
LC-2/ad GDSC1 4.9767 8.1118 2.1546 4.947
NCI-H2029 GDSC1 4.9975 6.4268 2.8797 0.6274
NCI-H2172 GDSC1 4.9989 9.3305 1.602 8.7087
NCI-H322M GDSC1 5.0009 7.7662 2.324 3.7613
NCI-H720 GDSC1 5.0027 6.3348 2.9162 0.4853
NCI-H2869 GDSC1 5.0247 9.2765 1.6442 8.3567
COR-L95 GDSC1 5.025 6.4386 2.8866 0.5796
NCI-H2731 GDSC1 5.0376 6.815 2.7464 1.1918
NCI-H2803 GDSC1 5.0862 7.1943 2.6152 1.8286
NCI-H2227 GDSC1 5.1195 7.1005 2.6696 1.4909
NCI-H1573 GDSC1 5.128 6.8379 2.7778 0.9501
LCLC-103H GDSC1 5.131 6.2981 2.9786 0.2309
NCI-H2405 GDSC1 5.1375 7.4552 2.5318 2.234
LC-1/sq GDSC1 5.1568 8.9026 1.9012 6.2918
RERF-LC-MS GDSC1 5.1611 8.1085 2.2622 3.8692
NCI-H2009 GDSC1 5.1653 7.1285 2.6797 1.3846
HCC15 GDSC1 5.1708 7.4811 2.5377 2.1521
NCI-H1436 GDSC1 5.195 6.8382 2.8065 0.7671
COR-L88 GDSC1 5.2012 6.8979 2.7863 0.8469
Lu-134-A GDSC1 5.2263 7.6362 2.5005 2.2878
NCI-H1693 GDSC1 5.25 7.1774 2.6989 1.1978
NCI-H2291 GDSC1 5.2671 7.2462 2.6794 1.2742
COR-L321 GDSC1 5.2792 6.7592 2.8702 0.4711
NCI-H1703 GDSC1 5.2817 10.0133 1.4628 8.9622
NCI-H196 GDSC1 5.2836 6.613 2.9243 0.3065
CPC-N GDSC1 5.2996 7.6891 2.5149 2.1033
A-427 GDSC1 5.3285 7.8815 2.449 2.4395
NCI-H1781 GDSC1 5.3364 7.074 2.7763 0.7767
LOU-NH91 GDSC1 5.3373 6.9272 2.8315 0.5671
NCI-H2110 GDSC1 5.3472 8.9085 2.0113 5.1598
NCI-H2122 GDSC1 5.3498 6.9503 2.828 0.5713
SBC-1 GDSC1 5.3678 7.0573 2.7956 0.6779
NCI-H1838 GDSC1 5.3997 7.2821 2.7238 0.9429
NCI-H1304 GDSC1 5.4001 6.7305 2.9262 0.2544
COR-L303 GDSC1 5.4124 6.7426 2.9265 0.2493
Lu-99A GDSC1 5.4155 7.6303 2.5942 1.5352
ChaGo-K-1 GDSC1 5.4363 7.5378 2.6404 1.2862
NCI-H1915 GDSC1 5.441 7.0951 2.8111 0.5723
NCI-H810 GDSC1 5.4588 6.8857 2.8934 0.3124
NCI-H1623 GDSC1 5.4594 8.2354 2.3662 2.7317
NCI-H2369 GDSC1 5.4692 7.3001 2.7462 0.7938
NCI-H1435 GDSC1 5.474 7.2074 2.7828 0.6511
NCI-H2141 GDSC1 5.4761 7.1489 2.8053 0.5702
HOP-92 GDSC1 5.5023 9.3383 1.9077 5.5344
NCI-H2591 GDSC1 5.5358 8.7649 2.1795 3.739
DMS 114 GDSC1 5.5469 9.6415 1.797 6.1674
NCI-H1651 GDSC1 5.5581 7.6221 2.661 1.0754
NCI-H292 GDSC1 5.5858 7.2336 2.8174 0.4676
NCI-H522 GDSC1 5.6076 7.8652 2.5881 1.3602
NCI-H1155 GDSC1 5.6442 7.2159 2.8459 0.3576
SW1271 GDSC1 5.6636 7.5952 2.7155 0.7685
NCI-H2023 GDSC1 5.7181 7.6027 2.7347 0.6619
NCI-H2170 GDSC1 5.7224 11.0695 1.2478 9.3313
Lu-135 GDSC1 5.7659 7.5409 2.776 0.4988
Lu-139 GDSC1 5.7691 7.6893 2.7232 0.6697
NCI-H290 GDSC1 5.7776 7.4428 2.8155 0.3803
NCI-H1944 GDSC1 5.7922 12.0169 0.8487 11.6188
IST-SL1 GDSC1 5.8162 7.4954 2.8113 0.3747
NCI-H510A GDSC1 5.8167 7.553 2.791 0.4294
IST-SL2 GDSC1 5.8184 7.6591 2.7536 0.5398
NCI-H1734 GDSC1 5.834 8.1948 2.5592 1.2748
NCI-H748 GDSC1 5.8378 7.8429 2.694 0.7279
NCI-H2373 GDSC1 5.8885 7.5673 2.8128 0.3411
HCC44 GDSC1 5.8892 8.5148 2.4582 1.6914
NCI-H1792 GDSC1 5.9212 7.844 2.7265 0.5684
NCI-H1666 GDSC1 6.0727 8.0104 2.7248 0.4951
NCI-H209 GDSC1 6.0741 8.0436 2.7135 0.5275
NCI-H513 GDSC1 6.0934 12.4724 0.8272 11.0501
NCI-H2461 GDSC1 6.1295 7.9333 2.7732 0.3442
EMC-BAC-2 GDSC1 6.1497 12.0993 1.0352 9.6952
NCI-H2595 GDSC1 6.1634 8.2217 2.6837 0.5706
NCI-H661 GDSC1 6.1891 13.441 0.434 13.0581
NCI-H446 GDSC1 6.2057 8.1113 2.7389 0.3981
NCI-H2347 GDSC1 6.2584 8.2975 2.6928 0.4975
RERF-LC-Sq1 GDSC1 6.3318 8.7175 2.5691 0.8482
SW1573 GDSC1 6.4076 8.5171 2.6709 0.4896
NCI-H23 GDSC1 6.5154 8.4282 2.7412 0.2851
NCI-H1650 GDSC1 6.516 8.5902 2.6853 0.4079
NCI-H2228 GDSC1 6.5391 8.9795 2.5551 0.7683
NCI-H2030 GDSC1 6.573 14.0258 0.4045 12.3564
A-549 GDSC1 6.5898 8.3576 2.7913 0.1791
NCI-H1299 GDSC1 6.6722 8.7286 2.694 0.3335
⏷ Show the Full List of 171 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 4.4772 6.6871 2.5063 3.5652
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-4 GDSC1 -0.5079 2.842 -0.7324 48.5308
TE-15 GDSC1 0.9791 9.4739 -1.8551 40.4595
KYSE-450 GDSC1 3.2407 11.0658 -0.5953 26.9675
OE19 GDSC1 3.7434 7.0898 1.8015 10.8515
TE-8 GDSC1 4.1002 6.836 2.1905 6.8085
T.T GDSC1 4.1989 6.0463 2.6317 3.2853
KYSE-140 GDSC1 4.2892 7.9899 1.7633 9.4547
TE-1 GDSC1 4.5514 8.7193 1.5935 9.9378
TE-11 GDSC1 4.5801 6.932 2.4559 3.6994
KYSE-520 GDSC1 4.5887 6.7246 2.5544 3.0122
KYSE-270 GDSC1 4.6556 7.3887 2.2924 4.6784
KYSE-70 GDSC1 4.7126 7.4678 2.2907 4.5665
TE-6 GDSC1 4.7636 11.1679 0.5521 16.0925
TE-10 GDSC1 5.0663 7.0359 2.6706 1.5504
KYSE-150 GDSC1 5.1154 7.3135 2.5801 1.987
TE-5 GDSC1 5.1227 6.9078 2.7481 1.0935
KYSE-510 GDSC1 5.2098 7.0442 2.7333 1.0755
KYSE-180 GDSC1 5.4147 9.6783 1.7013 7.0746
OE21 GDSC1 5.4337 7.8943 2.4956 2.0326
TE-9 GDSC1 5.6189 7.2424 2.8269 0.4222
OE33 GDSC1 5.6402 12.6614 0.4418 14.3425
EC-GI-10 GDSC1 5.7405 7.3494 2.8346 0.346
COLO 680N GDSC1 5.8706 7.6148 2.7894 0.4092
KYSE-410 GDSC1 8.1286 22.9535 -2.8071 21.967
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Caov-4 GDSC1 3.8792 6.084 2.3997 5.8441
IGROV-1 GDSC1 3.9292 5.8829 2.5326 4.6886
OC 314 GDSC1 4.1617 8.8239 1.2611 13.41
TOV-112D GDSC1 4.1737 9.1728 1.0979 14.4759
OVTOKO GDSC1 4.2117 7.681 1.8586 8.9769
FU-OV-1 GDSC1 4.2316 6.611 2.3877 4.9846
TYK-nu GDSC1 4.2378 5.8658 2.7377 2.46
OAW42 GDSC1 4.2504 6.277 2.5566 3.7068
Caov-3 GDSC1 4.3085 6.0321 2.7038 2.5497
ES-2 GDSC1 4.3665 6.9679 2.3069 5.2443
JHOS-2 GDSC1 4.4553 5.8003 2.883 1.1754
OV56 GDSC1 4.467 5.7045 2.9279 0.9171
EFO-27 GDSC1 4.4722 9.99 0.9171 14.7301
RMG-I GDSC1 4.6042 9.9048 1.0547 13.4538
OVCAR-8 GDSC1 4.6261 7.9504 2.0116 6.749
OVISE GDSC1 4.8202 9.4917 1.4061 10.5079
A2780 GDSC1 4.8534 10.7961 0.7981 14.3601
OVKATE GDSC1 4.9957 6.9503 2.6718 1.6342
OVCAR-4 GDSC1 5.144 10.6778 1.0568 11.9508
DOV13 GDSC1 5.2035 6.8233 2.8157 0.7229
Kuramochi GDSC1 5.2216 7.9274 2.3741 3.0537
TOV-21G GDSC1 5.3388 6.7575 2.8938 0.366
OVK18 GDSC1 5.4437 6.8989 2.8831 0.3467
OV-90 GDSC1 5.504 11.6579 0.83 12.433
OAW28 GDSC1 5.5865 8.3785 2.37 2.5276
OVCAR-5 GDSC1 5.7852 7.6034 2.7609 0.5352
EFO-21 GDSC1 5.9071 11.8389 1.0054 10.4107
OVCAR-3 GDSC1 5.9231 7.3228 2.9089 0.1404
SK-OV-3 GDSC1 7.2025 14.8036 0.4315 10.9119
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-2 GDSC1 3.5182 4.8507 2.7392 4.3096
MIA PaCa-2 GDSC1 4.1116 5.9152 2.6381 3.4404
SUIT-2 GDSC1 4.1975 5.8431 2.7242 2.6358
MZ-PC-1 GDSC1 4.2024 7.2353 2.0685 7.4408
PaTu 8988t GDSC1 4.277 7.5518 1.9673 7.9867
DAN-G GDSC1 4.2816 7.8665 1.8179 9.0764
QGP-1 GDSC1 4.4542 6.4874 2.5833 3.0806
PaTu 8902 GDSC1 4.4894 7.6291 2.0743 6.637
SW1990 GDSC1 4.5028 6.5667 2.5758 3.0348
Panc 03.27 GDSC1 4.5708 6.9903 2.4238 3.9412
CFPAC-1 GDSC1 4.754 6.4021 2.7802 1.3521
HuP-T3 GDSC1 4.764 7.0019 2.5297 2.85
PSN1 GDSC1 4.8695 8.838 1.7505 8.0006
PL4 GDSC1 4.9155 6.9838 2.6179 2.0541
Panc 10.05 GDSC1 5.0775 7.4248 2.514 2.4291
Capan-1 GDSC1 5.1031 6.8286 2.7705 1.0078
KP-4 GDSC1 5.1293 6.4263 2.9325 0.3572
YAPC GDSC1 5.15 6.6411 2.8621 0.5827
HPAC GDSC1 5.4794 7.1756 2.7968 0.5977
HuP-T4 GDSC1 5.5041 7.7041 2.6052 1.3848
Panc 02.03 GDSC1 5.5254 7.8312 2.5644 1.5621
SU.86.86 GDSC1 5.5591 7.5651 2.6833 0.9786
Panc 08.13 GDSC1 5.7697 7.6844 2.7252 0.6622
Hs 766T GDSC1 5.7823 7.5507 2.7787 0.482
BxPC-3 GDSC1 5.7938 7.7482 2.7114 0.6953
HPAF-II GDSC1 5.84 7.8557 2.6902 0.7402
AsPC-1 GDSC1 6.0209 8.0978 2.6732 0.6844
Panc 04.03 GDSC1 6.1221 7.8562 2.7973 0.2921
KP-3 GDSC1 6.6375 8.6302 2.7154 0.3002
Capan-2 GDSC1 6.6644 14.7338 0.1314 13.5862
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1 4.4605 6.4015 2.6256 2.781
IST-Mes1 GDSC1 5.0265 9.2721 1.6474 8.3302
NCI-H2052 GDSC1 5.2047 7.4077 2.5848 1.8404
MPP 89 GDSC1 5.4338 7.1482 2.7886 0.6576
NCI-H28 GDSC1 5.47 7.5291 2.6587 1.1673
NCI-H2452 GDSC1 6.2836 8.2314 2.7255 0.4003
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 4.3407 11.3702 0.1372 19.6958
VCaP GDSC1 4.6796 6.1108 2.8633 1.0028
22Rv1 GDSC1 4.7742 7.888 2.1347 5.5232
PC-3 GDSC1 5.1956 7.3737 2.5944 1.7993
DU145 GDSC1 6.5008 8.1196 2.8403 0.1281
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.5988 6.1251 2.8189 1.3419
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RVH-421 GDSC1 3.4628 5.2275 2.5078 6.3143
WM115 GDSC1 3.7146 4.9223 2.848 2.8806
G-mel GDSC1 3.7547 6.392 2.1562 8.1006
G-361 GDSC1 3.93 6.3964 2.2836 6.5863
A-431 GDSC1 3.9301 6.4189 2.2728 6.6691
SK-MEL-5 GDSC1 3.965 6.7466 2.1377 7.5991
CHL-1 GDSC1 4.0047 14.0708 -1.4708 27.7102
LB2518-MEL GDSC1 4.0131 5.6573 2.6961 3.2516
LB373-MEL-D GDSC1 4.0547 5.7229 2.6919 3.1831
A2058 GDSC1 4.111 5.5784 2.7933 2.3361
UACC-257 GDSC1 4.14 6.3824 2.4358 4.8596
SK-MEL-30 GDSC1 4.193 7.3296 2.0162 7.8576
UACC-62 GDSC1 4.2602 6.3446 2.5313 3.8664
Hs 940.T GDSC1 4.2711 6.5349 2.4493 4.4358
MZ-MEL-2 GDSC1 4.381 7.2145 2.1997 5.9937
Mel Ho GDSC1 4.4094 8.2425 1.7253 9.3901
SK-MEL-28 GDSC1 4.4469 5.4024 3.0374 0.4254
CP66-MEL GDSC1 4.4567 5.9298 2.8295 1.4836
SK-MEL-1 GDSC1 4.4678 5.9838 2.8122 1.5701
CP50-MEL-B GDSC1 4.4911 6.486 2.6053 2.8581
WT2-iPS GDSC1 4.5051 5.653 2.9658 0.6867
SK-MEL-2 GDSC1 4.5315 6.2758 2.7204 2.0338
COLO 783 GDSC1 4.5455 6.2317 2.7468 1.8468
COLO 792 GDSC1 4.5636 8.1482 1.8763 7.8826
RPMI-7951 GDSC1 4.5882 7.1846 2.3452 4.4546
Mel JuSo GDSC1 4.594 8.4955 1.7305 8.8485
MMAc-SF GDSC1 4.6339 6.001 2.8862 0.9387
SH-4 GDSC1 4.6553 6.6445 2.6268 2.4166
WM35 GDSC1 4.6982 6.7176 2.6182 2.398
IPC-298 GDSC1 4.7262 6.3804 2.7756 1.4135
A-388 GDSC1 4.7765 6.7278 2.6551 2.0422
DJM-1 GDSC1 4.8576 6.558 2.766 1.2989
SK-MEL-3 GDSC1 4.8905 6.6044 2.7627 1.2765
HT-144 GDSC1 4.8914 7.0772 2.5656 2.4072
COLO 679 GDSC1 4.898 7.7748 2.2611 4.383
VMRC-MELG GDSC1 4.901 6.5159 2.8031 1.0595
A101D GDSC1 4.9413 6.0394 2.9994 0.2565
MZ-MEL-7 GDSC1 4.9764 7.3821 2.4792 2.8052
HMV-II GDSC1 4.9836 9.9762 1.2845 10.8921
Hs 938.T GDSC1 4.9967 6.4959 2.8531 0.7376
GAK GDSC1 5.0254 7.0512 2.6446 1.7455
451Lu GDSC1 5.0847 6.734 2.7992 0.8942
IGR-37 GDSC1 5.1015 6.4366 2.918 0.4179
LOX-IMVI GDSC1 5.2909 6.8784 2.8309 0.6001
IST-MEL1 GDSC1 5.297 10.6959 1.1504 10.9623
IGR-1 GDSC1 5.3184 6.7749 2.8797 0.4185
WM793 GDSC1 5.3287 8.7903 2.0536 4.9172
MeWo GDSC1 5.3408 10.6986 1.1779 10.6769
COLO 829 GDSC1 5.4235 7.9546 2.4657 2.2115
M14 GDSC1 5.5391 7.3563 2.7538 0.7131
WM1552C GDSC1 5.6259 7.5341 2.7229 0.7675
SK-MEL-24 GDSC1 5.7427 7.2159 2.8819 0.2351
WM278 GDSC1 5.7465 7.8029 2.6717 0.8759
COLO 800 GDSC1 5.9743 12.191 0.8834 10.989
A-375 GDSC1 6.1328 7.544 2.9067 0.1057
EquiPSC Line K2 GDSC1 5.6368 8.3989 2.3863 2.3679
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 4.3019 15.76 -2.0763 28.7569
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 GDSC1 3.8471 5.7313 2.5487 4.7941
MES-SA GDSC1 4.2772 5.8071 2.7864 2.0556
EW-8 GDSC1 4.3767 6.3113 2.6175 3.0034
SW684 GDSC1 4.6221 5.679 3.0057 0.4178
Rh41 GDSC1 4.6771 6.3293 2.7727 1.4967
KYM-1 GDSC1 4.7272 6.2088 2.846 1.037
TE 441.T GDSC1 4.7783 6.4879 2.7567 1.45
Rh30 GDSC1 4.851 6.8128 2.6572 1.9175
G-402 GDSC1 4.9483 7.3778 2.466 2.9364
SK-LMS-1 GDSC1 4.9746 6.703 2.7622 1.1825
VA-ES-BJ GDSC1 5.023 6.8836 2.712 1.3837
HT-1080 GDSC1 5.0726 6.4434 2.9041 0.4826
SW982 GDSC1 5.1203 6.4398 2.9242 0.3876
GCT GDSC1 5.2502 7.0706 2.7408 1.0026
SW872 GDSC1 5.2816 6.8225 2.8479 0.5455
Hs 633.T GDSC1 5.3897 6.9783 2.8336 0.527
RKN GDSC1 5.5071 13.9849 -0.2898 18.4831
A-204 GDSC1 5.6684 7.9866 2.5675 1.3961
MFH-ino GDSC1 5.8947 7.9299 2.6847 0.7238
SK-UT-1 GDSC1 6.144 7.5026 2.9241 0.0847
RD GDSC1 6.317 8.2401 2.7347 0.3652
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-N87 GDSC1 -1.8287 10.9346 -5.3047 54.892
Hs 746.T GDSC1 0.2393 5.3494 -0.74 42.3617
TGBC11TKB GDSC1 2.8558 3.564 2.742 7.0278
SNU-1 GDSC1 3.318 4.3974 2.8034 4.4993
GCIY GDSC1 3.7248 5.5074 2.5701 4.9848
HGC-27 GDSC1 4.0397 5.593 2.7431 2.848
NUGC-4 GDSC1 4.2118 6.1434 2.5947 3.5217
SNU-16 GDSC1 4.2388 5.8075 2.7645 2.2754
Fu97 GDSC1 4.2528 6.1562 2.6141 3.2906
MKN1 GDSC1 4.2716 7.403 2.0355 7.4959
RERF-GC-1B GDSC1 4.3011 8.1466 1.6955 9.9143
NUGC-3 GDSC1 4.3369 7.0979 2.2259 5.9124
SCH GDSC1 4.4548 6.2795 2.6767 2.4511
AGS GDSC1 4.5396 6.3613 2.6875 2.2286
IM95 GDSC1 4.6521 10.1949 0.9474 14.0048
MKN45 GDSC1 4.6666 5.7937 2.981 0.4799
OCUM-1 GDSC1 4.884 7.1214 2.5426 2.5619
ECC10 GDSC1 4.8961 8.4087 1.9688 6.4089
RF-48 GDSC1 4.9796 7.1742 2.5701 2.2425
23132/87 GDSC1 5.0238 6.5474 2.8449 0.7492
SNU-5 GDSC1 5.2743 6.6667 2.9017 0.3749
HSC-39 GDSC1 5.279 6.8876 2.8227 0.6391
MKN7 GDSC1 5.2886 7.9195 2.4126 2.7139
MKN28 GDSC1 5.4568 8.0642 2.4367 2.3295
TMK-1 GDSC1 5.5678 7.3299 2.7752 0.6165
SNG-M GDSC1 3.5271 6.2272 2.0605 9.596
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HTC-C3 GDSC1 3.9038 5.5878 2.6571 3.8164
CGTH-W-1 GDSC1 4.2543 6.2164 2.5872 3.4792
IHH-4 GDSC1 4.4288 6.1051 2.7391 2.0909
FTC-133 GDSC1 4.7334 7.7555 2.1708 5.3608
CAL-62 GDSC1 4.7731 6.1454 2.8918 0.7684
8305C GDSC1 4.8545 6.3698 2.8399 0.9298
BHT-101 GDSC1 4.9742 7.8018 2.293 4.0175
TT GDSC1 5.1638 6.6678 2.8577 0.5893
ML-1 [Human leukemia] GDSC1 5.1963 7.0195 2.737 1.0716
ASH-3 GDSC1 5.2119 6.7055 2.8631 0.5369
B-CPAP GDSC1 5.2532 6.4687 2.9638 0.2205
KMH-2 GDSC1 5.3369 7.443 2.6329 1.4281
WRO GDSC1 5.4126 7.2862 2.7277 0.9152
TT2609-C02 GDSC1 5.7925 7.5187 2.7941 0.4321
8505C GDSC1 6.1048 8.0774 2.7131 0.5133
K5 GDSC1 6.3158 8.1071 2.7803 0.2666
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H3118 GDSC1 3.4756 6.4316 1.9168 10.886
SAT [Human HNSCC] GDSC1 3.5573 6.7774 1.8101 11.4161
SCC-9 GDSC1 3.6917 4.9708 2.8085 3.2447
LB771-HNC GDSC1 3.9833 5.644 2.6831 3.4198
BB30-HNC GDSC1 4.0426 6.7129 2.2097 6.8256
SCC-25 GDSC1 4.1373 8.7186 1.2948 13.2548
FaDu GDSC1 4.1473 6.4691 2.3994 5.1123
BHY GDSC1 4.1691 6.1042 2.5861 3.6825
SCC-15 GDSC1 4.1805 6.4797 2.4164 4.9013
HSC-4 GDSC1 4.2131 6.1889 2.5743 3.6654
PCI-15A GDSC1 4.2461 6.6751 2.3668 5.1024
OSC-19 GDSC1 4.2931 6.6796 2.3953 4.7771
BICR 22 GDSC1 4.4334 6.7908 2.432 4.1836
Detroit 562 GDSC1 4.484 6.4706 2.6081 2.8534
SAS GDSC1 4.4919 7.9722 1.9123 7.8094
OSC-20 GDSC1 4.6781 9.5448 1.2822 11.7355
Ca9-22 GDSC1 4.6958 8.4852 1.8038 8.0609
HSC-2 GDSC1 4.82 7.0792 2.5266 2.7718
BICR 31 GDSC1 4.8223 6.4179 2.8061 1.132
PCI-38 GDSC1 4.8498 8.7682 1.7707 7.9082
KON GDSC1 4.9249 7.1927 2.5336 2.5511
BICR 78 GDSC1 5.0476 7.7252 2.3682 3.3885
HSC-3 GDSC1 5.0659 6.5649 2.856 0.6687
CAL-33 GDSC1 5.1086 9.8153 1.4443 9.5066
PCI-30 GDSC1 5.1124 8.3467 2.128 4.8496
CAL-27 GDSC1 5.1263 9.7165 1.5025 9.0721
SCC-4 GDSC1 5.2032 7.1737 2.6791 1.3451
HO-1-u-1 GDSC1 5.2266 7.6555 2.4926 2.3336
PCI-04B GDSC1 5.2307 12.6495 0.1639 16.9373
BB49-HNC GDSC1 5.2753 7.4013 2.6211 1.5588
HO-1-N-1 GDSC1 5.2932 7.0356 2.7727 0.8263
SKN-3 GDSC1 5.3769 7.2951 2.7089 1.028
DOK GDSC1 5.4528 11.8549 0.7016 13.3284
JHU-022 GDSC1 5.6394 8.1581 2.4859 1.8309
BICR 10 GDSC1 5.642 7.0209 2.913 0.2028
PCI-06A GDSC1 6.0716 14.0532 0.0663 15.286
PE/CA-PJ15 GDSC1 6.1885 11.5592 1.3055 7.9796
KOSC-2 GDSC1 6.2122 8.4842 2.6072 0.7913
JHU-011 GDSC1 6.3307 16.3155 -0.8434 18.9097
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-4 GDSC1 3.715 5.5995 2.5176 5.421
639V GDSC1 4.314 5.7064 2.8506 1.5789
UM-UC-3 GDSC1 4.3888 8.4436 1.6132 10.2542
HT-1197 GDSC1 4.4179 6.0137 2.7731 1.8926
SW780 GDSC1 4.5952 6.2049 2.7838 1.5486
BFTC-905 GDSC1 4.6537 5.9182 2.9278 0.7176
CAL-29 GDSC1 4.6839 6.8843 2.5371 2.9472
RT-112 GDSC1 4.6953 6.361 2.7685 1.4955
KU-19-19 GDSC1 4.7234 6.0983 2.8881 0.8339
5637 GDSC1 4.7828 6.6103 2.708 1.72
SW1710 GDSC1 4.8278 7.0302 2.5521 2.5961
647V GDSC1 5.2198 6.9059 2.7912 0.8103
HT-1376 GDSC1 5.4513 6.9377 2.8721 0.3736
J82 GDSC1 5.4636 7.4118 2.7013 0.984
TCCSUP GDSC1 5.6206 7.1793 2.85 0.357
T24 GDSC1 5.9846 7.887 2.7355 0.5077
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DSH1 GDSC1 2.147 9.1895 -0.6207 31.4893
BPH-1 GDSC1 3.6757 19.4383 -4.4202 35.7229
OV17R GDSC1 3.7261 7.2107 1.7279 11.462
OVMIU GDSC1 3.9605 12.0884 -0.5171 24.1181
SW756 GDSC1 4.0785 5.8641 2.641 3.4977
OMC-1 [Human cervical carcinoma] GDSC1 4.2133 6.0281 2.649 3.1303
HeLa GDSC1 4.2873 5.909 2.7468 2.3004
DoTc2 4510 GDSC1 4.3256 6.549 2.4771 4.1059
C-4-I GDSC1 4.453 6.5546 2.5522 3.2971
SKN GDSC1 4.4608 6.7979 2.4455 4.0269
OVCA420 GDSC1 4.5002 7.4396 2.171 5.9065
JAR GDSC1 4.5116 6.7123 2.5152 3.4314
JEG-3 GDSC1 4.6069 6.5395 2.6463 2.3756
JHOS-3 GDSC1 4.6582 6.7581 2.5786 2.7226
MS751 GDSC1 4.7916 6.6573 2.6927 1.7961
OVCA433 GDSC1 4.8473 7.2242 2.4779 3.0366
HT-3 GDSC1 4.9001 8.3579 1.995 6.2174
ACC-OV7 GDSC1 4.9728 7.7718 2.3056 3.936
C-33 A GDSC1 4.9807 12.7465 -0.0636 18.8161
SW954 GDSC1 5.0553 12.0083 0.3513 16.4034
SiHa GDSC1 5.1263 6.3093 2.973 0.2467
ME-180 GDSC1 5.235 10.7302 1.0929 11.4855
HEC-1 GDSC1 5.3792 6.8634 2.8712 0.4122
Ca Ski GDSC1 5.4395 12.4747 0.3947 15.122
UWB1.289 GDSC1 5.5154 8.1743 2.4198 2.3443
PA-1 GDSC1 5.5241 7.4247 2.722 0.8478
NCC-IT GDSC1 5.5385 7.0278 2.8729 0.332
SKG-IIIa GDSC1 5.5446 7.0746 2.8586 0.3678
CAL-39 GDSC1 5.5496 7.5434 2.6876 0.9687
PEO1 GDSC1 5.556 7.9179 2.5438 1.6316
NT2-D1 GDSC1 5.737 8.8628 2.2425 3.045
LB831-BLC GDSC1 5.8223 7.6127 2.7718 0.4822
NEC8 GDSC1 5.8302 7.359 2.864 0.2449
HEY GDSC1 5.848 8.0521 2.6198 1.0042
SiSo GDSC1 6.0152 9.0152 2.3157 2.2685
KGN GDSC1 6.3275 8.1449 2.7715 0.2808
SW962 GDSC1 6.5049 8.5883 2.6819 0.4205
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

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4 Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714. Toxicol Sci. 2009 Apr;108(2):492-500. doi: 10.1093/toxsci/kfp033. Epub 2009 Feb 17.