Details of the Drug

General Information of Drug (ID: DMUMJGD)

• Drug Name: JWH-295
• Synonyms: JWH-295; CHEMBL407763

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 246.4
  Logarithm of the Partition Coefficient (xlogp); 5
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 1
• Chemical Identifiers:
  Formula: C17H26O
  IUPAC Name: (1R,3R)-3-[4-(2-methylbutan-2-yl)phenyl]cyclohexan-1-ol
  Canonical SMILES: CCC(C)(C)C1=CC=C(C=C1)[C@@H]2CCC[C@H](C2)O
  InChI: InChI=1S/C17H26O/c1-4-17(2,3)15-10-8-13(9-11-15)14-6-5-7-16(18)12-14/h8-11,14,16,18H,4-7,12H2,1-3H3/t14-,16-/m1/s1
  InChIKey: NGNJEMWGXAUJKO-GDBMZVCRSA-N
• Cross-matching ID:
  PubChem CID: 44452602
  TTD ID: D0G9EU

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 2 (CB2)	TTMSFAW	CNR2_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cannabinoid receptor 2 (CB2)	DTT	CNR2	3.82E-02	-0.43	-1.18

References

• [1] Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35.