Details of the Drug

General Information of Drug (ID: DMURVPF)

• Drug Name: Dendritic cell vaccine
• Synonyms: Dendritic cell vaccine (injectable, head and neck cancer); Dendritic cell vaccine (injectable, head and neck cancer), National Cancer Institute; Mutant p53 peptide pulsed dendritic cell vaccine (injectable, head and neck cancer), National Cancer Institute

Indication

Disease Entry	ICD 11	Status	REF
Head and neck cancer	2D42	Phase 1	[1]

• Drug Type: Vaccine
• Cross-matching ID: TTD ID: D05CPS

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cellular tumor antigen p53 (TP53)	TT7SBF5	P53_HUMAN	Not Available	[2]

Molecular Expression Atlas of This Drug

• The Studied Disease: Head and neck cancer
• ICD Disease Classification: 2D42

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cellular tumor antigen p53 (TP53)	DTT	TP53	7.01E-01	0.06	0.09

References

• [1] ClinicalTrials.gov (NCT00404339) Vaccine Therapy in Treating Patients With Head and Neck Cancer. U.S. National Institutes of Health.
• [2] Vaccination with p53-peptide-pulsed dendritic cells, of patients with advanced breast cancer: report from a phase I study. Cancer Immunol Immunother. 2004 Jul;53(7):633-41.