Details of the Drug

General Information of Drug (ID: DMV4OKR)

• Drug Name: L-erythro-3-hydroxyaspartate
• Synonyms: (3R)-3-hydroxy-L-aspartate; erythro-3-Hydroxy-L-aspartate; L-erythro-3-hydroxyaspartate; L-erythro-beta-hydroxyaspartate; erythro-3-hydroxy-aspartic acid; CHEBI:58196; (3R)-3-hydroxy-L-aspartate anion; (3R)-3-hydroxy-L-aspartate(1-); ZB015320

Indication

Disease Entry	ICD 11	Status	REF
Neurodegenerative disorder	8A20-8A23	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 148.09
  Logarithm of the Partition Coefficient (xlogp); -3.1
  Rotatable Bond Count (rotbonds); 1
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 5
• Chemical Identifiers:
  Formula: C4H6NO5-
  IUPAC Name: (2S,3R)-2-azaniumyl-3-hydroxybutanedioate
  Canonical SMILES: [C@H]([C@H](C(=O)[O-])O)(C(=O)[O-])[NH3+]
  InChI: InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/p-1/t1-,2+/m0/s1
  InChIKey: YYLQUHNPNCGKJQ-NHYDCYSISA-M
• Cross-matching ID:
  PubChem CID: 28125549
  ChEBI ID: CHEMBL58196
  TTD ID: D0U6DZ
• Drug ADMET Endpoint Profile (DAE)NEW: Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serine Racemase (SRR)	TTZFUY6	SRR_HUMAN	Inhibitor	[1]

References

• [1] Inhibition of human serine racemase, an emerging target for medicinal chemistry. Curr Drug Targets. 2011 Jun;12(7):1037-55.